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https://www.readbyqxmd.com/read/28454406/carcinoid-syndrome-from-a-carcinoid-tumor-of-the-pancreas-without-liver-metastases-a-case-report-and-literature-review
#1
Nikolaos Zavras, Demetrios Schizas, Nikolaos Machairas, Vasileia Damaskou, Nikolaos Economopoulos, Anastasios Machairas
A carcinoid tumor of the pancreas (CTP) is a rare pancreatic neoplasm, and usually presents with carcinoid syndrome (CS). CS consists of the classic symptom triad of cutaneous flushing, diarrhea and valvular disease, and occurs in the majority of patients with liver metastases. In the present study, the patient presented with symptoms of CS. A diagnosis of CTP with CS was suspected due to high levels of urine 5-hydroxyindolacetic acid, and this was confirmed by a fine-needle aspiration biopsy. Computed tomography showed extended lymphadenopathy, but no liver metastases...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454335/effect-of-laser-therapy-on-plasma-expression-of-vegf-and-bfgf-in-infants-with-cutaneous-hemangioma
#2
Fagang Wang, Rongjian Xu, Qian Xu, Yongqian Cao, Li Lin, Wei Dang
The present study aimed to investigate the effect of laser therapy on the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the plasma of infants diagnosed with cutaneous hemangioma, in order to identify biomarkers for assessing the clinical efficacy of laser therapy. In total, 109 infants with superficial abdominal hemangioma received laser treatment, of which 74 were diagnosed in the proliferation phase, 20 in the regression phase and 15 in the involution phase...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454216/microrna-31-functions-as-an-oncogenic-microrna-in-cutaneous-squamous-cell-carcinoma-cells-by-targeting-rhotbt1
#3
Nengxing Lin, Yu Zhou, Xin Lian, Yating Tu
Cutaneous squamous cell carcinoma (cSCC) is a malignancy of epidermal keratinocytes that is responsible for ~20% of annual skin cancer-associated mortalities. Accumulating evidence demonstrates that the dysregulation of micro (mi)RNAs serves a significant role in the tumorigenesis and progression of human cSCC. MicroRNA-31 (miR-31) is upregulated in cSCC and is involved in cSCC development. However, the underlying mechanism remains unclear. The present study demonstrated that miR-31 is upregulated in the cSCC cell line, A-431, and that miR-31 expression contributes to the cell proliferation and invasion of cSCC...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454108/telomere-erosion-in-nf1-tumorigenesis
#4
Rhiannon E Jones, Julia W Grimstead, Ashni Sedani, Duncan Baird, Meena Upadhyaya
Neurofibromatosis type 1 (NF1; MIM# 162200) is a familial cancer syndrome that affects 1 in 3,500 individuals worldwide and is inherited in an autosomal dominant fashion. Malignant Peripheral Nerve Sheath Tumors (MPNSTs) represent a significant cause of morbidity and mortality in NF1 and currently there is no treatment or definite prognostic biomarkers for these tumors. Telomere shortening has been documented in numerous tumor types. Short dysfunctional telomeres are capable of fusion and it is considered that the ensuing genomic instability may facilitate clonal evolution and the progression to malignancy...
April 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28453867/syndecan-1-regulates-dendritic-cell-migration-in-cutaneous-hypersensitivity-to-haptens
#5
Marco Averbeck, Stephanie Kuhn, Johannes Bühligen, Martin Götte, Jan C Simon, Tobias Polte
In human dendritic cells (DC), we previously demonstrated in vitro that syndecan-1 (SDC1) is downregulated during maturation correlating with enhanced motility. We investigated the effects of SDC1 on DC migration in vivo during TNCB(2,4,6-trinitro-1-chlorobenzene)-induced cutaneous hypersensitivity reaction (CHS) in mice. We show that DC in SDC1-deficient mice migrated faster and at a higher rate to lymph nodes draining the hapten-painted skin. Adoptive transfer of SDC1-deficient hapten- and fluorochrome-labelled DC into wild type (WT) mice led to increased and faster migration of DC to paracortical lymph nodes, and to a stronger CHS compared to WT DC...
April 28, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28453592/-cutaneous-myiasis-due-to-cochliomyia-hominivorax-associated-with-seborrheic-dermatitis
#6
Perla Calderón H, Camilo Rojas E, Werner Apt B, Douglas Castillo O
Myiasis is an infestation of tissues and organs of humans and animals by Diptera larvae (flies, horseflies, mosquitoes). They are located at different body sites, and classified clinically as cutaneous, visceral and cavitary. We report a 26-year-old woman with a history of seborrheic dermatitis and recent trip to Brazil. She presented with a seven days history of suppurating wounds in the parieto-occipital area of the scalp. At physical examination we found three ulcers of approximately 1.5 cm each, with multiple mobile larvae inside...
February 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28449475/a-non-randomized-retrospective-observational-study-on-the-subcutaneous-esophageal-reconstruction-after-esophagectomy-is-it-feasible-in-high-risk-patients
#7
Jae Ho Chung, Sung Ho Lee, Eunjue Yi, Jae Seung Jung, Jung Wook Han, Tae Sik Kim, Ho Sung Son, Kwang Taik Kim
BACKGROUND: Esophageal reconstruction after esophagectomy is a complex procedure with high morbidity and mortality. Anastomotic leakage is more severe and frequent in patients with preoperative comorbidities and may present with septic conditions. Considering the possibility of an easier management of such cases, we evaluated the safety and feasibility of subcutaneous esophageal reconstruction in patients with high operative risks. METHODS: We performed a non-randomized retrospective observational study on the 75 (subcutaneous: 21, intrathoracic: 54) esophageal cancer patients who underwent esophageal reconstruction either through subcutaneous or intrathoracic route between January 2003 and February 2015...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449237/the-environmental-and-host-associated-bacterial-microbiota-of-arctic-seawater-farmed-atlantic-salmon-with-ulcerative-disorders
#8
C Karlsen, K F Ottem, Øyvind Jakobsen Brevik, M Davey, H Sørum, H C Winther-Larsen
The Norwegian aquaculture of Atlantic salmon (Salmo salar L.) is hampered by ulcerative disorders associated with bacterial infections. Chronic ulceration may provide microenvironments that disturb the normal microbial biodiversity of external surfaces. Studying the composition of microbial communities in skin ulcers will enhance our understanding of ulcer aetiology. To achieve this, we tested marine farmed Atlantic salmon and sampled the base and edge of ulcers at the end of winter (April) and end of summer (September), in addition to skin mucus of healthy individuals...
April 27, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28448985/total-skin-electron-beam-therapy-as-part-of-multimodal-treatment-strategies-for-primary-cutaneous-t-cell-lymphoma
#9
Khaled Elsayad, Katharina H Susek, Hans T Eich
Total-skin electron beam therapy (TSEBT) is one of most effective treatments that has been used for cutaneous T-cell lymphoma. Low-dose TSEBT regimens (10-12 Gy) appear to be an effective alternative to conventional-dose TSEBT (30-36 Gy), yielding short-term remission of cutaneous manifestations with minimal toxicity. TSEBT can be administered to patients any time after a diagnosis of mycosis fungoides (MF). Patients requiring rapid relief from cutaneous lesions or symptoms may particularly benefit from TSEBT as an initial therapy...
April 25, 2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28448860/a-unique-presentation-of-renal-cell-transformation-into-renal-cell-carcinoma-in-subcutaneous-fatty-tissue-post-twenty-year-old-healing-gun-shot-wound-a-case-report
#10
Awadh R Alqahtani, Mohammed A Alqahtani
INTRODUCTION: Renal cell carcinoma (RCC) is the most common malignancy in the genitourinary tract, and is among the 10 most common cancers in both males and females. PRESENTATION OF CASE: We report a case of a 61-year-old male who presented with a cutaneous lesion on his left back side at a site where he had undergone several surgeries - including Left nephrectomy - twenty years ago for a gun-shot wound he sustained which penetrated his abdomen. DISCUSSION: At that time pathology reports turned out to be normal, specially left kidney pathology report which was negative for any malignancy...
March 21, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28448668/prognostic-indication-of-sarcopenia-for-wound-complication-after-total-laryngectomy
#11
Virginie Achim, Jasper Bash, Alia Mowery, Alexander R Guimaraes, Ryan Li, Josh Schindler, Mark Wax, Peter Andersen, Daniel Clayburgh
Importance: Postoperative wound complications after total laryngectomy (TL) increase hospital stay, costs, and delay adjuvant therapy when indicated. Recently, sarcopenia has been identified as a predictor of postoperative complications in patients undergoing major surgery but has not been assessed in head and neck surgery patients. Objective: To determine the incidence of sarcopenia in patients with squamous cell carcinoma (SCC) undergoing TL and evaluate its association with the development of postoperative wound complications...
April 27, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28448623/development-of-the-cutaneous-microbiome-in-the-preterm-infant-a-prospective-longitudinal-study
#12
Mohan Pammi, Jacqueline L O'Brien, Nadim J Ajami, Matthew C Wong, James Versalovic, Joseph F Petrosino
BACKGROUND: Neonatal sepsis in preterm infants is often due to organisms that colonize the skin including Staphylococcus spp. and Candida spp. Development and maturation of the skin microbiome in the neonatal period, especially in preterm infants, may be critical in preventing colonization with pathogens and subsequent progression to neonatal sepsis. Development of the skin microbiome in preterm infants or its determinants in the first 4 weeks of life has not been evaluated. METHODS: We evaluated the skin microbiome from three body sites, antecubital fossa, forehead and gluteal region, in a prospective cohort of 15 preterm (birth weight < 1500 g and < 32 weeks of gestation) and 15 term neonates...
2017: PloS One
https://www.readbyqxmd.com/read/28448022/development-of-an-economical-dna-delivery-system-by-acufection-and-its-application-to-skin-research
#13
Yu-Jei Lin, Tsung-Lin Lee, Chia-Chi Ku
Dysregulation of immune response in skin is associated with numerous human skin disorders. Direct transfer of immune-related genes into skin tissue is a fascinating approach to investigate immune modulation of cutaneous inflammation in mouse models of human diseases. Here we present a cost-effective protocol that delivered naked DNA in mouse skin and leads to transgene expression. The method is coined "acufection", denoting acupuncture-mediated DNA transfection. To perform acufection, mouse skin was first infused with DNA in phosphate-buffered saline (PBS) and then pricked lightly with a bundle of acupuncture needles to facilitate the absorption of DNA and transfection into cells...
April 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447958/mycoplasma-induced-rash-and-mucositis-in-a-young-patient-with-red-eyes-oral-mucositis-and-targetoid-cutaneous-vesicles
#14
Rikinder Sandhu, Chinmaya Mareddy, Marc Itskowitz, Charles E Mount, Nitin Bhanot, Zaw Min
No abstract text is available yet for this article.
May 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28447661/the-nonsystemic-vasculitic-neuropathies
#15
REVIEW
Michael P Collins, Robert D Hadden
Nonsystemic vasculitic neuropathy (NSVN) is an under-recognized single-organ vasculitis of peripheral nerves that can only be diagnosed with a nerve biopsy. A Peripheral Nerve Society guideline group published consensus recommendations on the classification, diagnosis and treatment of NSVN in 2010, and new diagnostic criteria for vasculitic neuropathy were developed by the Brighton Collaboration in 2015. In this Review, we provide an update on the classification, diagnosis and treatment of NSVN. NSVN subtypes include Wartenberg migratory sensory neuropathy and postsurgical inflammatory neuropathy...
April 27, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28447489/forodesine-in-the-treatment-of-cutaneous-t-cell-lymphoma
#16
Daniel J Lewis, Madeleine Duvic
Cutaneous T-cell lymphoma (CTCL) is characterized by the accumulation of neoplastic CD4+ T lymphocytes in the skin. Given the lack of curative treatments for CTCL, there is a significant need for new, superior therapies. Forodesine is a transition-state analogue that inhibits purine nucleoside phosphorylase. Because it selectively targets T lymphocytes, it represents a drug of interest for the treatment of CTCL. Areas covered: Phase I/II dose-ranging studies of intravenous (IV) and oral forodesine demonstrated its activity, safety, and tolerability for refractory CTCL...
April 27, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28447347/abundance-of-the-benign-melanocytic-universe-dermoscopic-histopathological-correlation-in-nevi
#17
REVIEW
Nora Woltsche, Karin Schmid-Zalaudek, Teresa Deinlein, Katrin Rammel, Rainer Hofmann-Wellenhof, Iris Zalaudek
The broad universe of "melanocytic nevi" includes a variety of different subtypes, which can be classified either due to their morphology, epidemiology, genetic alterations or risk for developing melanoma. Regarding morphology, on the one hand macroscopic/clinical and on the other hand histopathological appearance were used to subdivide in the past, often resulting in confusion and poor interobserver agreement, while nowadays dermoscopy presents the clinician's precious bridge between naked-eye examination and histopathological diagnostics, allowing prediction of the lesions' histopathology, follow up and monitoring over time without need of excision...
May 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28447236/the-history-of-an-unknown-dermatological-wax-collection-from-cluj-napoca-university-iuliu-hatieganu-romania
#18
Alexandru-Dumitru Tataru, Dan Tataru, Maria Grazia Roccia, Katlein França, Massimo Fioranelli, Torello Lotti
Among the dermatological wax collections across Europe, one of the latest created is the collection from Cluj-Napoca University, Romania. The initiator was Professor Coriolan Tataru and the moulage artist employed was Dr. Richard Hoffmann. Between the years 1923 and 1928, around 200 wax moulages were made, all realised after patients hospitalised in the clinic. The majority of cases represent the dermatological infectious pathology of that time: syphilis, cutaneous tuberculosis and mycetomas. Other interesting moulages represent genodermatoses, pelagra, different cutaneous cancers, and atypical aspects of common diseases like psoriasis and eczemas...
April 26, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28446858/a-case-of-autoimmune-polyglandular-syndrome-ype-2-associated-with-atypical-form-of-scleromyxedema
#19
Oleksander Prylutskyi, Olga Prylutska, Anatoliy Degonskyi, Kseniia Tkachenko
BACKGROUND: Autoimmune polyglandular syndrome type 2 represents an uncommon endocrine disorder composed by Addison's disease with autoimmune thyroid disease (Schmidt's syndrome) and/or type 1 diabetes mellitus. Scleromyxedema is a rare progressive cutaneous mucinosis usually associated with systemic involvement and paraproteinemia. To the best of our knowledge, there is no case report of Schmidt's syndrome associated with scleromyxedema. CASE DETAILS: A 34-year-old woman was admitted to Donetsk Clinical Territorial Medical Association due to acute general weakness, reduced vision, dryness of integuments, memory decline, fatigue, weight loss, rash on the face trunk and extremities...
September 2016: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/28446739/suspected-cutaneous-leishmaniasis-in-a-sample-of-westerns-sicily-residents-what-correlation-with-occupation
#20
Maria Gabriella Verso, Fabrizio Vitale, Germano Castelli, Federica Bruno, Antonella Migliazzo, Maria Rita Bongiorno, Fiorella Santi, Giuseppe Pistone, Emanuele Amodio, Diego Picciotto
BACKGROUND: Leishmaniasis is a widespread infectious disease, but there is not much information about its prevalence in high risk occupational categories. OBJECTIVES: The aim of this study is to assess the prevalence of Leishmania immunological positivity in human skin tissues collected from subjects living in Western Sicily, with suspected cutaneous Leishmania infection, in order to explore the risk possibly related to occupation. METHODS: 318 consecutive subjects (M/F ratio=1...
April 21, 2017: La Medicina del Lavoro
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