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https://www.readbyqxmd.com/read/29346333/platelet-rich-plasma-new-insights-for-cutaneous-wound-healing-management
#1
REVIEW
Deborah Chicharro-Alcántara, Mónica Rubio-Zaragoza, Elena Damiá-Giménez, José M Carrillo-Poveda, Belén Cuervo-Serrato, Pau Peláez-Gorrea, Joaquín J Sopena-Juncosa
The overall increase of chronic degenerative diseases associated with ageing makes wound care a tremendous socioeconomic burden. Thus, there is a growing need to develop novel wound healing therapies to improve cutaneous wound healing. The use of regenerative therapies is becoming increasingly popular due to the low-invasive procedures needed to apply them. Platelet-rich plasma (PRP) is gaining interest due to its potential to stimulate and accelerate the wound healing process. The cytokines and growth factors forming PRP play a crucial role in the healing process...
January 18, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29346178/multiple-primary-malignancies-and-prolonged-survival-in-a-patient-with-widespread-metastatic-cutaneous-melanoma
#2
Anna M Rose, Utsav K Radia, Rong Luo, Helen Kalirai, Channa N Jayasena, Philip Luthert, Sarah E Coupland, Geoffrey E Rose
No abstract text is available yet for this article.
January 17, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29346172/apremilast-use-in-a-case-of-cicatricial-ectropion-secondary-to-severe-lamellar-ichthyosis
#3
Jean-Paul J Abboud, Alexander Whittington, Masih Ahmed, Jesse T Himebaugh, Lee A Wiley, Ahmad Haffar, John Nguyen
Ichthyosis is a cutaneous disorder characterized by excessive amounts of dry thickened skin surface scales. Ocular manifestations of ichthyosis include cicatricial ectropion, which may cause exposure keratoconjunctivitis and rarely corneal perforation. Topical emollients, anti-inflammatory ointments, and systemic retinoids have been used to control the disease process, while surgical correction with donor graft has been reserved for severe cases involving corneal exposure. The authors report a case of a Caucasian male with lamellar ichthyosis with severe bilateral upper and lower eyelid cicatricial ectropion and corneal ulceration requiring surgical correction...
January 17, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29346044/clinical-features-treatment-and-outcomes-of-cutaneous-and-oral-squamous-cell-carcinoma-in-avian-species
#4
Ashley M Zehnder, Laura A Swift, Ash Sundaram, Brian L Speer, Geoff P Olsen, Michelle G Hawkins, Joanne Paul-Murphy
OBJECTIVE To determine the clinical features, treatment, and outcomes of treatment for oral and cutaneous squamous cell carcinoma (SCC) in avian species. DESIGN Retrospective case series with nested cohort study. ANIMALS 87 client-owned birds of various species with histologically confirmed SCC of the skin or oral cavity. PROCEDURES Clinicians entered case information through an online survey tool. Data were collected regarding patient signalment, concurrent conditions, treatments, adverse effects, and clinical outcomes...
February 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29345319/endothelial-cells-enhance-adipose-mesenchymal-stromal-cell-mediated-matrix-contraction-via-alk-receptors-and-reduced-follistatin-potential-role-of-endothelial-cells-in-skin-fibrosis
#5
Hanneke N Monsuur, Lenie J van den Broek, Pieter Koolwijk, Frank B Niessen, Susan Gibbs
Abnormal cutaneous wound healing can lead to formation of fibrotic hypertrophic scars. Although several clinical risk factors have been described, the cross-talk between different cell types resulting in hypertrophic scar formation is still poorly understood. The aim of this in vitro study was to investigate whether endothelial cells (EC) may play a role in skin fibrosis, e.g. hypertrophic scar formation after full-thickness skin trauma. Using a collagen/elastin matrix, we developed an in vitro fibrosis model to study the interaction between EC and dermal fibroblasts or adipose tissue-derived mesenchymal stromal cells (ASC)...
January 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29345316/histopathological-findings-in-pregnancy-associated-cutaneous-hyperpigmentation
#6
Angel Fernandez-Flores, Juan Manuel Barja, Alejandro Vilas-Sueiro, Antonio Alija
Hyperpigmentation in pregnancy is a common phenomenon, experienced to some degree by up to 90% of pregnant women. It mainly involves sun-exposed areas, but it can extend to non-exposed zones. Cases with extensive hyperpigmentation are rarely reported. In this paper, we describe the case of a 30-year-old phototype V woman in her 37th week of pregnancy, who presented with brownish hyperpigmentation of the skin in extensive areas, including both axillae, the abdomen, and the lowest part of the back. In the abdomen, there was a reinforcement of the hyperpigmentation through the linea nigra and the umbilicus...
January 18, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29345298/leishmania-amazonensis-isolated-from-human-visceral-leishmaniasis-histopathological-analysis-and-parasitological-burden-in-different-inbred-mice
#7
Celeste da Silva Freitas de Souza, Kátia da Silva Calabrese, Ana Lúcia Abreu-Silva, Luiz Otávio Pereira Carvalho, Flávia de Oliveira Cardoso, Maria Elizabeth Moraes Cavalheiros Dorval, Elisa Teruya Oshiro, Patrícia Flávia Quaresma, Célia Maria Ferreira Gontijo, Raquel da Silva Pacheco, Maria Isabel Doria Rossi, Sylvio Celso Gonçalves da Costa, Tânia Zaverucha do Valle
Leishmania amazonensis is a major etiological agent of human cutaneous leishmaniasis in the Americas; nevertheless there are some reports of this species causing visceral disease in dogs and men. In the present work we have studied a Leishmania strain isolated from a human case of visceral leishmaniasis. We have infected different mouse strains and analyzed the development of the disease, studying the parasite's ability to visceralize and whether this ability is influenced by host genetics. Female BALB/c, C57BL/6, C57BL/10, CBA, DBA/2, and C3H/He mice were subcutaneously infected with 104 L...
January 18, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29345220/tissue-impression-smears-as-a-supplementary-diagnostic-method-for-histopathology-in-cutaneous-leishmaniasis-in-sri-lanka
#8
Nuwani H Manamperi, M Vipula C de Silva, Nishantha Pathirana, Wimal Abeyewickreme, Nadira D Karunaweera
Cutaneous leishmaniasis (CL) is diagnosed mainly by light microscopy of smears made using lesion material. Histopathology is usually done in atypical presentations or when lesion smears are negative. Tissue impression smears (TIS) made from skin biopsy specimens were compared with histopathology for the diagnosis of CL. Out of the 111 patients included, 83 (74.8%) were positive by either methods. The TIS was positive in 70.3% whereas histopathology was positive in 56.8% of patients. Tissue impression smears can be used as a supplementary diagnostic test that gives sensitive and rapid results when tissue biopsies are used as the source of lesion material for diagnosis of CL...
January 15, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29345019/a-vascular-mechanism-to-explain-thermally-mediated-variations-in-deep-body-cooling-rates-during-the-immersion-of-profoundly-hyperthermic-individuals
#9
Joanne N Caldwell, Anne M J van den Heuvel, Pete Kerry, Mitchell J Clark, Gregory E Peoples, Nigel A S Taylor
Physiologically trivial time differences for cooling the intrathoracic viscera of hyperthermic individuals have been reported between cold- and temperate-water immersion treatments. One explanation for that observation is reduced convective heat delivery to the skin during cold immersion, and this experiment was designed to test both the validity of that observation, and its underlying hypothesis. Eight healthy males participated in four head-out, water immersions: two when normothermic, and two following exercise-induced, moderate-profound hyperthermia...
January 18, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29344981/severe-and-recurrent-levamisole-induced-cutaneous-vasculopathy
#10
J M Fernandez Armenteros, A Veà Jódar, C Matas Nadal, C Cortés Pinto, X Soria Gili, R M Martí Laborda, F Vilardell Villellas, J M Casanova Seuma
Levamisole-induced vasculopathy is a thrombotic and necrotic vasculitis usually seen in cocaine users due to adulteration of the drug with this veterinary medication. Some cases can be severe or very extensive, which could lead to sepsis and death.
January 18, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29344752/transforming-dermatologic-imaging-for-the-digital-era-metadata-and-standards
#11
Liam J Caffery, David Clunie, Clara Curiel-Lewandrowski, Josep Malvehy, H Peter Soyer, Allan C Halpern
Imaging is increasingly being used in dermatology for documentation, diagnosis, and management of cutaneous disease. The lack of standards for dermatologic imaging is an impediment to clinical uptake. Standardization can occur in image acquisition, terminology, interoperability, and metadata. This paper presents the International Skin Imaging Collaboration position on standardization of metadata for dermatologic imaging. Metadata is essential to ensure that dermatologic images are properly managed and interpreted...
January 17, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29344728/-cutaneous-graft-versus-host-disease
#12
REVIEW
A Cho, U Just, R Knobler
BACKGROUND: Graft-versus-host disease (GvHD) is a complex multiorgan disease, which can occur as a complication following allogeneic stem cell transplantation. Involvement of the skin represents the most common appearance of GvHD. The role of the dermatologist is critical for diagnosis and initiation of treatment. OBJECTIVES: The aim of this article is to provide a comprehensive review of the cutaneous types of GvHD and to present the most recent data on diverse therapy options for its acute and chronic form allowing the clinician to establish a definite diagnosis and to initiate proper therapy...
January 17, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29344607/bosentan-for-cutaneous-ulcers-in-anti-mda5-dermatomyositis
#13
Andrea Combalia, Priscila Giavedoni, Lorena Tamez, Josep M Grau-Junyent, Jose M Mascaró
No abstract text is available yet for this article.
January 17, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29344468/levetiracetam-induced-skin-hyperpigmentation-an-extremely-rare-undesirable-side-effect
#14
Hussein Algahtani, Siham Marghalani, Mohamed Satti, Bader Shirah
Levetiracetam is one of the newer second-generation antiepileptic drugs with multiple mechanisms of action. Cutaneous side effects due to levetiracetam are rarely reported in the literature. In this article, we describe a patient with skin hyperpigmentation due to the treatment with levetiracetam with complete resolution after discontinuation of the medication. In addition, we review the topic and hypothesize the mechanism behind this rare complication. To the best of our knowledge, this is the first report of skin hyperpigmentation as a side effect of levetiracetam in the literature...
December 2017: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/29344431/noncoding-rnas-in-wound-healing-a-new-and-vast-frontier
#15
REVIEW
Anna Luan, Michael S Hu, Tripp Leavitt, Elizabeth A Brett, Kevin C Wang, Michael T Longaker, Derrick C Wan
Significance: Wound healing requires a highly orchestrated coordination of processes that are not yet fully understood. Therefore, available clinical therapies are thus far limited in their efficacy in preventing and treating both chronic wounds and scars. Current gene-based therapeutics is largely based on our understanding of the protein-coding genome and proteins involved in known wound healing pathways. Recent Advances: Noncoding RNAs such as microRNAs and long noncoding RNAs have recently been found to be significant modulators of gene expression in diverse cellular pathways...
January 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29344430/an-improved-humanized-mouse-model-for-excisional-wound-healing-using-double-transgenic-mice
#16
Michael S Hu, Justin Cheng, Mimi R Borrelli, Tripp Leavitt, Graham G Walmsley, Elizabeth R Zielins, Wan Xing Hong, Alexander T M Cheung, Dominik Duscher, Zeshaan N Maan, Dre M Irizarry, Brad Stephan, Fereydoun Don Parsa, Derrick C Wan, Geoffrey C Gurtner, Hermann Peter Lorenz, Michael T Longaker
Objective: Splinting full-thickness cutaneous wounds in mice has allowed for a humanized model of wound healing. Delineating the epithelial edge and assessing time to closure of these healing wounds via macroscopic visualization have remained a challenge. Approach: Double transgenic mice were created by crossbreeding K14-Cre and ROSAmT/mG reporter mice. Full-thickness excisional wounds were created in K14-Cre/ROSAmT/mG mice (n = 5) and imaged using both normal and fluorescent light on the day of surgery, and every other postoperative day (POD) until wound healing was complete...
January 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29344321/fixed-drug-eruption-to-supplement-containing-ginkgo-biloba-and-vinpocetine-a-case-report-and-review-of-related-cutaneous-side-effects
#17
Philip R Cohen
BACKGROUND: Fixed drug eruption is a cutaneous reaction to a systemic agent that typically presents as an annular or oval erythematous patch or blister and subsequently resolves with postinflammatory hyperpigmentation at the site. Ginkgo biloba leaf extract and vinpocetine are nutritional supplements used to enhance memory in patients with dementia and age-related memory impairment conditions such as Alzheimer's disease. PURPOSE: To describe a fixed drug eruption in a man who repeatedly developed pruritus and macular erythema on his distal penile shaft after ingesting a natural product containing Ginkgo biloba and vinpocetine...
October 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29344320/pyoderma-gangrenosum-associated-granulomatosis-with-polyangitis-a-case-report-and-literature-review
#18
Matthew B Zarraga, Nicole Swenson, Brad Glick
Granulomatosis with polyangitis, formerly known as Wegener's granulomatosis, is a multi-system vasculitis that has a variable clinical presentation. Although uncommon, cutaneous symptoms can be the initial presenting symptom of granulomatosis with polyangitis. We present an unusual case of pyoderma gangrenosum followed by a diagnosis of granulomatosis with polyangitis. We also provide a review of current literature on therapeutic options.
October 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29344286/identification-of-biomarker-for-cutaneous-squamous-cell-carcinoma-using-microarray-data-analysis
#19
Wei Wei, Yan Chen, Jie Xu, Yu Zhou, Xinping Bai, Ming Yang, Ju Zhu
Cutaneous squamous cell carcinoma (CSCC) is one of the most malignant tumors worldwide. We aimed to explore the molecular mechanism of this CSCC and screen feature genes that can function as the biomarker of CSCC and thus provide a theoretical basis for the pathogenesis research and development of medicine. The method of microarray data analysis was used in this study to explore the differentially expressed genes between tissues of normal specimens and tissues of patients with CSCC. Besides, functional enrichment analysis and signal pathway were performed on these genes to screen the feature genes that are closely associated with CSCC can function as the potential biomarkers of CSCC...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29343900/direct-electrical-injury-to-brachial-plexus
#20
Maksud Mubarak Devale, Gaurav Jatin Kadakia, Vicky Ghewarchand Jain, Rohit Prakash Munot
Electrical current can cause neurological damage directly or by conversion to thermal energy. However, electrical injury causing isolated brachial plexus injury without cutaneous burns is extremely rare. We present a case of a 17-year-old boy who sustained accidental electrical injury to left upper extremity with no associated entry or exit wounds. Complete motor and sensory loss in upper limb were noted immediately after injury. Subsequently, the patient showed partial recovery in muscles around the shoulder and in ulnar nerve distribution at 6 months...
May 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
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