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https://www.readbyqxmd.com/read/29149740/skin-reducing-mastectomy-and-direct-to-implant-reconstruction-in-giant-phyllodes-tumour-of-breast-case-report
#1
Francesco Ciancio, Alessandro Innocenti, Luigi Cagiano, Aurelio Portincasa, Domenico Parisi
BACKGROUND: The phyllodes tumour of the breast comprises about 0.5% of all neoplasms of the breast. CASE REPORT: we present the case of a female patient (55 years old) suffering from giant phyllodes tumour (>10cm) of the left breast, who underwent Skin Reducing Mastectomy (SRM) and reconstruction with silicone breast implant (Bostwick Technique). DISCUSSION AND CONCLUSION: In selected patients with large sized breasts (C-D cup) and poor surface area of skin involved, a valid technique in the treatment of this pathology is the Skin-Reducing Mastectomy and immediate reconstruction with implants (DTI=direct to implant)...
November 13, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29132118/primary-malignant-melanoma-of-the-female-urethra-report-of-a-rare-neoplasm-of-the-urinary-tract
#2
Namita Bhutani, Pradeep Kajal, Devendra Pawar
INTRODUCTION: Melanoma is a malignant tumor that can affect any area of the anatomical economy. Its occurance in the female urethra is extremely rare. We report a case of primary malignant urethral melanoma developed in an elderly female patient. PRESENTATION OF CASE: A 70 years old female presented with dysuria, poor stream, gross haematuria, intermittent blood spots, and a painful mass. On physical examination, there were no suspicious lesions on the skin. On external genital examination, a lesion at the level of the urethral meatus was observed...
November 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29118526/panfolliculoma-a-clinical-case-report
#3
Roberto Estrada-Castañón, María Elisa Vega-Memije, Juan Carlos Cuevas-González, María de Guadalupe Chávez-López
Panfolliculoma is a benign neoplasm of follicular differentiation, and its morphological characteristics are similar to those of trichoblastoma, but it shows greater follicular differentiation. A 55-year-old female patient, visited for a dermatological consultation, presented comedo-like lesions on the eyelids, which were accompanied by moderate pruritus that spread gradually. On examination, the patient had localized dermatosis on the face, which symmetrically affected both upper eyelids and to a lesser extent the lower eyelids...
October 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/29114849/risk-of-skin-cancer-among-patients-with-myotonic-dystrophy-type-1-based-on-primary-care-physician-data-from-the-united-kingdom-clinical-practice-research-datalink
#4
Youjin Wang, Ruth M Pfeiffer, Rotana Alsaggaf, Wilhelmine Meeraus, Julia C Gage, Lesley A Anderson, Renée C Bremer, Nikoletta Nikolenko, Hanns Lochmuller, Mark H Greene, Shahinaz M Gadalla
Myotonic dystrophy type 1 (DM1) is an inherited multisystem neuromuscular disorder caused by a CTG trinucleotide repeat expansion in the DMPK gene. Recent evidence documents that DM1 patients have an increased risk of certain cancers, but whether skin cancer risks are elevated is unclear. Using the U.K. Clinical Practice Research Datalink (CPRD), we identified 1,061 DM1 patients and 15,119 DM1-free individuals matched on gender, birth year (±2 years), attending practice, and registration year (±1 year). We calculated the hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of DM1 diagnosis with skin cancer risk using Cox proportional hazards models, for all skin cancers combined and by histological subtype...
November 7, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29107432/-reconstruction-of-abdo-perineal-resection-by-taylor-flap-about-68-patients
#5
D Boccara, K SerroR, J Lefevre, M Mimoun, M Chaouat
PURPOSES: Healing after abdomino-perineal resection is often difficult, especially in patients who have undergone radiation therapy. Vaginal reconstruction is also an important issue for the women who undergo this surgery. We describe and analyze here our series of perineal reconstructions with modified Taylor flaps. Between 2010 and 2016, 68 patients (52 women, 16 men) with cancer of the anal canal (53), adenocarcinoma of the lower rectum (9), or other malignant neoplasms of the perineum underwent reconstruction with a rectus abdominis myocutaneous (RAM) flap with an inferior pedicle and an oblique skin paddle...
October 26, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29104110/pseudomyogenic-hemangioendothelioma-of-skin-bone-and-soft-tissue-a-clinicopathological-immunohistochemical-and-fluorescence-in-situ-hybridization-study
#6
Dinesh Pradhan, Karen Schoedel, Richard L McGough, Sarangarajan Ranganathan, Uma N M Rao
Pseudomyogenic hemangioendothelioma (PHE) is an uncommon neoplasm with propensity for local recurrence. The tumor mimics epithelioid hemangioendothelioma and epithelioid sarcoma, representing a possible diagnostic pitfall. We investigated the clinicopathological, immunohistochemical and fluorescence in situ hybridization features of PHEs. Eight cases of PHE were retrieved from our pathology archives. The clinical and outcome information was available in six patients. In six cases the tumors were located in the lower limb while the upper limb was involved in two cases...
November 2, 2017: Human Pathology
https://www.readbyqxmd.com/read/29100621/clinical-and-histopathologic-findings-of-cutaneous-leiomyosarcoma-correlation-with-prognosis-in-12-patients
#7
E Rodríguez-Lomba, I Molina-López, V Parra-Blanco, R Suárez-Fernández, A Pulido-Pérez
INTRODUCTION: Cutaneous leiomyosarcoma is a malignant neoplasm derived from smooth muscle cells. Its low incidence hampers the development of specific protocols for diagnosis and treatment. OBJECTIVES: To describe the clinical and histopathologic characteristics of a series of primary and secondary cutaneous leiomyosarcomas and to determine how these characteristics correlate with prognosis. MATERIAL AND METHODS: We performed an observational, descriptive, retrospective study based on 17 cutaneous leiomyosarcomas in 12 patients diagnosed between January 1, 2000 and December 31, 2015...
October 31, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29093237/basal-cell-carcinoma-of-vermilion-mucosa-of-upper-lip-a-rare-case-report
#8
Reza Yaghoobi, Nastaran Ranjbari, Nader Pazyar, Maryam Foroozan, Amir Feily
Although basal cell carcinoma (BCC) is a common skin tumor, very rare cases of BCC arising from upper vermilion mucosa of lip have been reported previously. This tumor basically, originates from pillar structures and the involvement of the vermilion lip contrasts this concept so it is devoid of hair follicles and sweat glands. The exact pathogenesis of vermilion lip BCC is not clear but it has been postulated that the neoplasm originates from the pluripotential epithelial cells of the oral mucosa and epidermis...
July 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29078997/sebaceous-lesions-of-the-skin
#9
REVIEW
Jean Iacobelli, Nathan Tobias Harvey, Benjamin Andrew Wood
Sebaceous differentiation is commonly seen in cutaneous neoplasms, both in the context of lesions showing predominantly sebaceous differentiation (e.g., sebaceous adenoma, sebaceoma and sebaceous carcinoma), or as more focal sebaceous components in neoplasms with other primary lines of differentiation. Sebaceous changes can also be a component of benign cystic lesions or epidermal tumours, and sebaceous hyperplasia is commonly encountered. This review is intended to provide an overview of the cutaneous lesions with sebaceous differentiation, with a particular emphasis on facilitating histological diagnosis of neoplasms...
October 24, 2017: Pathology
https://www.readbyqxmd.com/read/29075488/mucin-poor-and-aggressive-mucinous-tubular-and-spindle-cell-carcinoma-of-the-kidney-two-case-reports
#10
Shiro Uchida, Koyu Suzuki, Mieko Uno, Fumi Nozaki, Chih-Ping Li, Eriko Abe, Teruo Yamauchi, Saya Horiuchi, Minobu Kamo, Kazunori Hattori, Yoji Nagashima
Mucinous tubular and spindle cell carcinoma (MTSCC) is a relatively rare renal epithelial neoplasm. Although MTSCC is considered to be a low-grade and indolent neoplasm, aggressive cases have been recently reported. The present study discussed two additional cases of high-grade MTSCC causing multiple distant metastases with a fatal course. In case 1, a 71-year-old patient presented with hematuria and pyuria. Computed tomography (CT) scan of the right kidney revealed a mass lesion, for which partial nephrectomy was performed...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29073726/reconstruction-of-extensive-thoracic-wall-defect-using-the-external-oblique-myocutaneous-flap-an-analysis-on-20-chinese-patients-with-locally-advanced-soft-tissue-sarcoma
#11
Chun-Meng Wang, Ruming Zhang, Peng Luo, Zhiqiang Wu, Biqiang Zheng, Yong Chen, Yingqiang Shi
BACKGROUND: Soft tissue sarcomas are rare neoplasms that can occur in the thoracic wall, abdominal wall, extremities, and inguinal region. Wide local resection, with precise histological margin control, results in large skin defects that are challenging to close. Various repair procedures, such as vertical rectus abdominis flaps (VRAM), latissimus dorsi flaps, and tensor fascia lata (TFL) flaps are used to cover broad thoracic wall defects. Although the cosmetic reconstruction results of using these flaps are often excellent, each has significant drawbacks...
October 26, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29072181/primary-clear-cell-sarcoma-of-the-dermis-mimicking-malignant-melanoma
#12
Ifeyinwa E Obiorah, Pauline Brenholz, Metin Özdemirli
BACKGROUND: Clear cell sarcoma is a rare malignant soft tissue neoplasm that typically involves tendons and aponeurosis. Clear cell sarcoma occurring in the dermis is an extremely rare occurrence. It is difficult to differentiate between this neoplasm and dermal malignant melanoma because they both have similar morphologic and immunohistochemical features. Although rare, clear cell sarcoma of the skin typically occur in the extremities. To our knowledge, there are no reported cases of primary clear cell sarcoma of the skin occurring in the neck...
October 26, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29071205/disseminated-paracoccidioidomycosis-prediagnosticated-as-neoplasm-an-important-challenge-in-diagnosis-using-rt-pcr
#13
Fabiana Rocha-Silva, Cássio Ferreira Guimarães, Edmundo Rocha de Oliveira Júnior, Sônia Maria de Figueiredo, Rachel Basques Caligiorne
This paper presents a case of disseminated paracoccidioidomycosis in a 62-year-old male patient, who lives in Belo Horizonte, MG, Brazil. The patient was hospitalized with icteric syndrome of cholestatic pattern and weight loss, with loss 30 kg in 5 months. The imaging of the abdomen showed lesion of infiltrative pattern, affecting gallbladder and intrahepatic bile ducts, suggesting neoplasia of malignant behavior, besides to presenting the yellow nail syndrome. Dermatological examination presented erythematous-infiltrated plaques in the occipital region...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29065794/prolonged-exposure-of-resveratrol-induces-reactive-superoxide-species-independent-apoptosis-in-murine-prostate-cells
#14
Sanjay Kumar, James Stokes, Udai P Singh, Karyn Scissum-Gunn, Rajesh Singh, Upender Manne, Manoj K Mishra
Nitric oxide, a signaling molecule, inhibits mitochondrial respiration by binding with cytochrome c oxidase, resulting in elevated production of reactive superoxide species (reactive oxygen and nitrogen) in the mitochondria and increased susceptibility to cell death. Generation of mitochondrial superoxide species can be suppressed by natural compounds such as resveratrol, a dietary polyphenol found in the skin of red fruits. In various cancer cells, resveratrol shows anti-oxidant and cancer preventive properties...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29062683/zoster-like-cutaneous-metastatic-adenocarcinoma-of-the-lung-a-case-report
#15
Kumpol Aiempanakit, Siripan Sangmala, Kanokphorn Chiratikarnwong, Sauvarat Auepemkiate
The zosteriform pattern is an infrequent cutaneous finding in oncologic patients who have a skin metastasis from a different primary source. Herein we report a case of adenocarcinoma of the lung which presented with zoster-like lesions along the thoracic dermatome. The histopathology indicated a metastatic neoplasm with variable glandular formations. Immunohistochemistry results pointed to the diagnosis of metastasized lung cancer. We suggest physicians should consider this rare diagnosis when experiencing similar cases...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29059099/cutaneous-presentation-of-mesothelioma-with-a-sarcomatoid-transformation
#16
Nikolai Klebanov, Bobby Y Reddy, Sameera Husain, David N Silvers, Marc E Grossman, Hensin Tsao
Malignant pleural mesothelioma is a rare neoplasm of mesodermal origin. Cutaneous involvement of malignant pleural mesothelioma is a very rare entity, with only 11 cases reported in the literature. Here, we describe the case of a 75-year-old man with stage IV epithelioid pleural mesothelioma, presenting with a cutaneous eruption 5 months after initial diagnosis, which revealed sarcomatoid features on skin biopsy. Histological analysis of malignancy progression through immunohistochemical staining of the pleural, lymph node, and skin tissue revealed gradual loss of calretinin and gain of desmin, supporting a transformation from epithelioid to sarcomatoid tissue...
October 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29057176/the-effect-of-conversion-from-a-calcineurin-inhibitor-to-sirolimus-on-skin-cancer-reduction-in-post-renal-transplantation-patients
#17
REVIEW
Aaron Smith, Wei Niu, Anand Desai
In kidney transplant patients, skin cancer is the most commonly involved neoplasm. More than 90% of post-transplantation skin cancers are nonmelanoma skin cancers (NMSCs). The majority of them are squamous cell carcinomas and basal cell carcinomas. Calcineurin inhibitors (CNIs) such as cyclosporine and tacrolimus are immunosuppressive agents given after solid organ transplantation, but they can also promote tumor growth. Sirolimus is a novel class of immunosuppressants and has been proven to have antineoplastic properties...
August 13, 2017: Curēus
https://www.readbyqxmd.com/read/29057137/a-large-lumbar-adnexal-neoplasm-presenting-characteristics-of-eccrine-poroma-and-poroid-hidradenoma
#18
Adamantios Michalinos, Dimitrios Schizas, Antonios Sarakinos, Georgios Athanasiadis, Eleftherios Spartalis, Dimitrios Vlachodimitropoulos, Theodore Troupis
Poroma is a rare benign neoplasm that derives from eccrine sweat glands epithelium. Its histological subtypes, with respect to its position within skin layers, are eccrine poroma, hidroacanthoma simplex, poroid hidradenoma, and dermal duct tumor. Poromas commonly exhibit benign clinical behavior as they are usually small and asymptomatic and do not exhibit malignant behavior. Although their histological subtypes share similar histological characteristics, they rarely coexist in the same tumor. In this report we present the case of an unusual poroma in terms of histological and clinical behavior as it was large and presented histological characteristic of both eccrine poroma and poroid hidradenoma...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/29056075/an-updated-review-of-the-jak1-2-inhibitor-ruxolitininb-in-the-philadelphia-negative-myeloproliferative-neoplasms
#19
Natalia Curto-Garcia, Claire N Harrison
Ruxolitinib (Rux), a JAK1/2 inhibitor, has been approved for patients with myelofibrosis and in polycythemia vera with inadequate response/intolerance to hydroxycarbamide. Studies have demonstrated that Rux improves disease-related symptoms and splenomegaly. A late emerging observation from two Phase III trials was that Rux was associated with survival advantage in comparison with placebo or other available therapies in myelofibrosis. Important data suggest that for polycythemia vera Rux improved control of blood counts...
October 23, 2017: Future Oncology
https://www.readbyqxmd.com/read/29055440/merkel-cell-carcinoma-with-fingolimod-treatment-for-multiple-sclerosis-a-case-report
#20
Kedar R Mahajan, Jennifer S Ko, Michael T Tetzlaff, Courtney W Hudgens, Steven D Billings, Jeffrey A Cohen
Neoplasms and reactivation of latent viruses have been observed in individuals taking fingolimod. Merkel cell carcinoma (MCC), a rare neuroendocrine skin cancer, is associated with immunosuppression and can be triggered by the oncogenic Merkel cell polyoma virus (MCPyV). We report a case of a 61-year-old man with multiple sclerosis who developed MCPyV-positive MCC 4 years after starting fingolimod. This is the second report of MCC associated with MCPyV in an individual on fingolimod.
October 2017: Multiple Sclerosis and related Disorders
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