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https://www.readbyqxmd.com/read/28542816/identification-of-microorganisms-isolated-from-counterfeit-and-unapproved-decorative-contact-lenses
#1
Adrian D Land, Katie L Penno, Jennifer L Brzezinski
All contact lenses (corrective/noncorrective) are considered Class II or Class III medical devices under the Federal Food, Drug, and Cosmetic Act, which also states that contact lenses can only be obtained with a prescription. The Forensic Chemistry Center of the US Food & Drug Administration has examined over 300 decorative, noncorrective contact lenses obtained without a prescription. Our observations indicate that 60% of the counterfeit lenses and 27% of the unapproved lenses examined were positive for microbial contamination...
May 24, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28525909/counterfeit-pennies-distinguishing-chromoblastomycosis-from-phaeohyphomycotic-infections
#2
Hadas Skupsky, Jacqueline Junkins-Hopkins
No abstract text is available yet for this article.
June 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28492262/the-secret-war-against-counterfeit-science
#3
David Cyranoski
No abstract text is available yet for this article.
May 10, 2017: Nature
https://www.readbyqxmd.com/read/28470953/mechanical-characteristics-of-counterfeit-reciproc-instruments-a-call-for-attention
#4
C S Rodrigues, V T L Vieira, H S Antunes, G De-Deus, C N Elias, E J L Moreira, E J N L Silva
AIM: To report here the main differences between the visual aspects of original and counterfeit Reciproc instruments, together with an evaluation of instrument bending resistance, cyclic fatigue, surface finish, Vickers microhardness, and chemical composition. METHODOLOGY: The visual aspects of original Reciproc R25 (VDW, Munich, Germany) and counterfeit Reciproc R25 instruments (claimed to be original, supposedly with dimensions similar to those of Reciproc R25 files, bought at www...
May 4, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28465571/upconversion-modulation-through-pulsed-laser-excitation-for-anti-counterfeiting
#5
Yingdong Han, Hongyu Li, Yangbo Wang, Yue Pan, Ling Huang, Feng Song, Wei Huang
Lanthanide-doped upconversion nanomaterials are emerging as promising candidates in optoelectronics, volumetric display, anti-counterfeiting as well as biological imaging and therapy. Typical modulations of upconversion through chemical methods, such as controlling phase, composition, morphology and size enable us to rationally manipulate emission profiles and lifetimes of lanthanide ions by using continuous-wave laser excitation. Here we demonstrate that under pulsed laser excitation the emission color of NaYF4:Er/Tm (2/0...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28456105/dual-mode-blue-emission-enhanced-up-conversion-luminescence-and-paramagnetic-properties-of-ytterbium-and-thulium-doped-ba2gdf7-multifunctional-nanophosphors
#6
Honglan Li, Guixia Liu, Jinxian Wang, Xiangting Dong, Wensheng Yu
A series of Ba2GdF7:Yb(3+), Tm(3+) nanophosphors (NPs) with dual-mode (down-conversion (DC) and upconversion (UC)) luminescence were successfully prepared by hydrothermal method at 180°C. The NPs have sphere-like morphology and cubic structure. Under the excitation of ultraviolet 355nm and near-infrared 980nm, Yb(3+) and Tm(3+) ions co-doped Ba2GdF7 phosphors exhibit bright blue dual-mode emission. The mechanism of UC emissions was determined three-photon absorption. The energy transfer processes from Yb(3+) to Tm(3+) were discussed in detail...
April 22, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28432962/gc-ms-quantitative-analysis-of-black-market-pharmaceutical-products-containing-anabolic-androgenic-steroids-seized-by-the-brazilian-federal-police
#7
Diana Brito da Justa Neves, Eloisa Dutra Caldas
The use of counterfeit or substandard medicines can have an important health impact, resulting in therapeutic failure, be toxic or even cause death. Anabolic steroids are a frequent target for counterfeiters worldwide, being the second most frequent counterfeited class in Brazil. The aims of this work were to optimize and validate a GC-MS method for the quantitative determination of anabolic steroids in tablet, aqueous suspension and oil solution forms, and to analyze pharmaceutical products sent to Brazilian Federal Police (BFP) for forensic analysis...
April 5, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28409930/ultrathin-nonlinear-metasurface-for-optical-image-encoding
#8
Felicitas Walter, Guixin Li, Cedrik Meier, Shuang Zhang, Thomas Zentgraf
Security of optical information is of great importance in modern society. Many cryptography techniques based on classical and quantum optics have been widely explored in the linear optical regime. Nonlinear optical encryption in which encoding and decoding involve nonlinear frequency conversions represents a new strategy for securing optical information. Here, we demonstrate that an ultrathin nonlinear photonic metasurface, consisting of meta-atoms with 3-fold rotational symmetry, can be used to hide optical images under illumination with a fundamental wave...
April 18, 2017: Nano Letters
https://www.readbyqxmd.com/read/28394563/unclonable-security-codes-designed-from-multicolor-luminescent-lanthanide-doped-y2o3-nanorods-for-anticounterfeiting
#9
Pawan Kumar, Kanika Nagpal, Bipin Kumar Gupta
The duplicity of important documents has emerged as a serious problem worldwide. Therefore, many efforts have been devoted to developing easy and fast anticounterfeiting techniques with multicolor emission. Herein, we report the synthesis of multicolor luminescent lanthanide-doped Y2O3 nanorods by hydrothermal method and their usability in designing of unclonable security codes for anticounterfeiting applications. The spectroscopic features of nanorods are probed by photoluminescence spectroscopy. The Y2O3:Eu(3+), Y2O3:Tb(3+), and Y2O3:Ce(3+) nanorods emit hypersensitive red (at 611 nm), strong green (at 541 nm), and bright blue (at 438 nm) emissions at 254, 305, and 381 nm, respectively...
April 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28393531/classification-of-ciprofloxacin-tablets-using-near-infrared-spectroscopy-and-chemometric-modeling
#10
Nathan Fuenffinger, Sergey Arzhantsev, Connie Gryniewicz-Ruzicka
Exposure to unknown, mislabeled, and counterfeit pharmaceutical products is a worldwide problem that presents a serious risk to public health. Near-infrared (NIR) spectroscopy can serve as a useful tool for screening pharmaceuticals in a rapid and cost-effective manner to ensure that drug products are safe and effective. By applying chemometric techniques to NIR spectra from finished products in tablet form, minor spectral differences are discoverable, even in instances where the tablets being evaluated contain the same active pharmaceutical ingredients (APIs)...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28387134/a-rapid-identification-method-for-calamine-using-near-infrared-spectroscopy-based-on-multi-reference-correlation-coefficient-method-and-back-propagation-artificial-neural-network
#11
Yangbo Sun, Long Chen, Bisheng Huang, Keli Chen
As a mineral, the traditional Chinese medicine calamine has a similar shape to many other minerals. Investigations of commercially available calamine samples have shown that there are many fake and inferior calamine goods sold on the market. The conventional identification method for calamine is complicated, therefore as a result of the large scale of calamine samples, a rapid identification method is needed. To establish a qualitative model using near-infrared (NIR) spectroscopy for rapid identification of various calamine samples, large quantities of calamine samples including crude products, counterfeits and processed products were collected and correctly identified using the physicochemical and powder X-ray diffraction method...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28376825/antiretroviral-therapy-supply-chain-quality-control-and-assurance-in-improving-people-living-with-hiv-therapeutic-outcomes-in-cameroon
#12
M P Ngogang Djobet, David Singhe, Julienne Lohoue, Christopher Kuaban, Jeanne Ngogang, Ernest Tambo
BACKGROUND: Evaluation of medication efficacy and safety is an essential guarantee to successful therapeutic outcome in public health practices. However, larger distribution chain supply in developing countries such as Cameroon is often challenged by counterfeit drugs, poor manufacturing, storage and degradation leading to health and patient adverse consequences. Yet, access to supply chain management in strengthening ARVs quality assurance and outcomes remains poorly documented. More than 53,000 patients have been enrolled on free ARVs medications, but little is documented on quality assurance and validity of safety for affected populations along the supply chain management since 2008...
April 4, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28372157/discrimination-of-whisky-brands-and-counterfeit-identification-by-uv-vis-spectroscopy-and-multivariate-data-analysis
#13
Angélica Rocha Martins, Márcio Talhavini, Maurício Leite Vieira, Jorge Jardim Zacca, Jez Willian Batista Braga
The discrimination of whisky brands and counterfeit identification were performed by UV-Vis spectroscopy combined with partial least squares for discriminant analysis (PLS-DA). In the proposed method all spectra were obtained with no sample preparation. The discrimination models were built with the employment of seven whisky brands: Red Label, Black Label, White Horse, Chivas Regal (12years), Ballantine's Finest, Old Parr and Natu Nobilis. The method was validated with an independent test set of authentic samples belonging to the seven selected brands and another eleven brands not included in the training samples...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28370721/detection-and-imaging-of-thermochromic-ink-compounds-in-erasable-pens-using-desorption-electrospray-ionization-mass-spectrometry
#14
Amin Khatami, Shamina S Prova, Aafreen K Bagga, Michelle Yan Chi Ting, Gurnoor Brar, Demian R Ifa
RATIONALE: Thermochromic ink pens are widely accessible worldwide and have gained popularity among the general public. These pens are very useful to undo mistakes while writing important documents or exams. They are also, however, misused in committing crimes such as counterfeiting checks or wills. Thus, the forensics community is in need of techniques that will allow these forgeries to be detected rapidly, reliably and conveniently. METHODS: Thermochromic ink compounds were investigated using Desorption Electrospray Ionization (DESI) coupled with an LTQ mass spectrometer and Thin-Layer Chromatography (TLC)...
June 30, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28366594/opportunities-for-collaboration-at-the-interface-of-pharmacovigilance-and-manufacturing
#15
Paul Beninger
A case can be made that much common ground exists between pharmacovigilance and pharmaceutical manufacturing. Of the 8 major US statutes that shaped the pharmaceutical industry since early in the 20th Century, 7 followed fatally catastrophic events related to the use of a manufactured product, and 1 followed the discovery of a counterfeit product. To facilitate an understanding of the interplay between pharmacovigilance and manufacturing, it is convenient to divide manufacturing into 3 categories: (1) upstream sourcing of materials: pharmacovigilance plays an important role when adverse event clusters are seen during routine vigilance detection processes and the suspicion turns to possibly contaminated source material, (2) the manufacturing process itself: pharmacovigilance may be called on to conduct a health hazard evaluation if a manufacturing deviation is detected after product release (the assessment can inform the depth of a recall), and (3) downstream distribution and product use: there is only light regulation of the interval between product distribution after manufacturing release and just before administration to patients, a time during which product may be subject to an out-of-specification determination for environmental controls or subject to malfeasant activities, such as counterfeit substitution or product diversion...
March 30, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28349715/a-review-of-existing-and-emerging-digital-technologies-to-combat-the-global-trade-in-fake-medicines
#16
Tim K Mackey, Gaurvika Nayyar
The globalization of the pharmaceutical supply chain has introduced new challenges, chief among them, fighting the international criminal trade in fake medicines. As the manufacture, supply, and distribution of drugs becomes more complex, so does the need for innovative technology-based solutions to protect patients globally. Areas covered: We conducted a multidisciplinary review of the science/health, information technology, computer science, and general academic literature with the aim of identifying cutting-edge existing and emerging 'digital' solutions to combat fake medicines...
May 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28335453/a-spatially-offset-raman-spectroscopy-method-for-non-destructive-detection-of-gelatin-encapsulated-powders
#17
Kuanglin Chao, Sagar Dhakal, Jianwei Qin, Yankun Peng, Walter F Schmidt, Moon S Kim, Diane E Chan
Non-destructive subsurface detection of encapsulated, coated, or seal-packaged foods and pharmaceuticals can help prevent distribution and consumption of counterfeit or hazardous products. This study used a Spatially Offset Raman Spectroscopy (SORS) method to detect and identify urea, ibuprofen, and acetaminophen powders contained within one or more (up to eight) layers of gelatin capsules to demonstrate subsurface chemical detection and identification. A 785-nm point-scan Raman spectroscopy system was used to acquire spatially offset Raman spectra for an offset range of 0 to 10 mm from the surfaces of 24 encapsulated samples, using a step size of 0...
March 18, 2017: Sensors
https://www.readbyqxmd.com/read/28327479/finger-printing-of-counterfeit-bevacizumab-and-identifying-it-before-clinical-use
#18
Thirumurthy Velpandian, Madhu Nath, Moksha Laxmi, Nabanita Halder
BACKGROUND: Bevacizumab is widely used for ophthalmic purposes. Recently, counterfeit bevacizumab has become a matter of concern. We analysed samples of suspected counterfeit formulations of bevacizumab and assessed the possibility of using simple tests in the clinic by ophthalmologists to prevent the use of counterfeit preparations in patients. METHODS: We did a protein analysis using Bradford assay and SDS-PAGE to confirm the presence of bevacizumab in 16 samples - 6 suspected and 10 others...
November 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/28325576/raman-spectroscopy-in-quality-control-of-chinese-herbal-medicine
#19
Dan-Dan Chen, Xiao-Fang Xie, Hui Ao, Ji-Lei Liu, Cheng Peng
BACKGROUND: Chinese herbal medicine (CHM) is of noteworthy international interest due to its potential impact on healthcare and manifests numerous opportunities for new drug development. However, solid scientific evidence is still lacking regarding the safety, efficacy, and quality of CHM-derived medicines. Success in the modernization and globalization of CHM is heavily dependent on the achievements in advanced analytical techniques for in-line checks of CHM quality. Raman spectroscopy has become increasingly valued as an analytical technique in the pharmaceutical sector because it can provide a detailed chemical fingerprint...
May 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28314392/combining-simplicity-with-cost-effectiveness-investigation-of-potential-counterfeit-of-proton-pump-inhibitors-through-simulated-formulations-using-thin-layer-chromatography
#20
Nejal M Bhatt, Vijay D Chavada, Mallika Sanyal, Pranav S Shrivastav
A simple, accurate and precise high-performance thin-layer chromatographic method has been developed and validated for the analysis of proton pump inhibitors (PPIs) and their co-formulated drugs, available as binary combination. Planar chromatographic separation was achieved using a single mobile phase comprising of toluene: iso-propranol: acetone: ammonia 5.0:2.3:2.5:0.2 (v/v/v/v) for the analysis of 14 analytes on aluminium-backed layer of silica gel 60 FG254. Densitometric determination of the separated spots was done at 290nm...
November 18, 2016: Journal of Chromatography. A
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