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https://www.readbyqxmd.com/read/28816430/dual-colorimetric-and-fluorescent-authentication-based-on-semiconducting-polymer-dots-for-anti-counterfeiting-applications
#1
Wei-Kai Tsai, Yung-Sheng Lai, Po-Jung Tseng, Chia-Hsien Liao, Yang-Hsiang Chan
Semiconducting polymer dots (Pdots) have recently emerged as a novel type of ultrabright fluorescent probes that can be widely used in analytical sensing and material science. Here we developed a dual visual agents based on Pdots for anti-counterfeiting applications. We first designed and synthesized two types of photoswitchable Pdots by incorporating photochromic dyes with multi-color semiconducting polymers to modulate their emission intensities and wavelengths. The resulting full-color Pdot assays showed the colorimetric and fluorescent dual-readout abilities to serve as an anti-counterfeiting reagent with low background interference...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28813419/vaccine-driven-pharmacodynamic-dissection-and-mitigation-of-fenethylline-psychoactivity
#2
Cody J Wenthur, Bin Zhou, Kim D Janda
Fenethylline, also known by the trade name Captagon, is a synthetic psychoactive stimulant that has recently been linked to a substance-use disorder and 'pharmacoterrorism' in the Middle East. Although fenethylline shares a common phenethylamine core with other amphetamine-type stimulants, it also incorporates a covalently linked xanthine moiety into its parent structure. These independently active pharmacophores are liberated during metabolism, resulting in the release of a structurally diverse chemical mixture into the central nervous system...
August 16, 2017: Nature
https://www.readbyqxmd.com/read/28807672/pharmacological-characterization-of-novel-synthetic-opioids-nso-found-in-the-recreational-drug-marketplace
#3
REVIEW
Michael H Baumann, Susruta Majumdar, Valerie Le Rouzic, Amanda Hunkele, Rajendra Uprety, Xi Ping Huang, Jin Xu, Bryan L Roth, Ying-Xian Pan, Gavril W Pasternak
Novel synthetic opioids (NSO) are increasingly encountered in illicit heroin and counterfeit pain pills. Many NSO are resurrected from older biomedical literature or patent applications, so limited information is available about their biological effects. Here we examined the pharmacology of three structurally-distinct NSO found in the recreational drug market: N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylbutyramide (butyrylfentanyl), 3,4-dichloro-N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) and 1-cyclohexyl-4-(1,2-diphenylethyl)piperazine (MT-45)...
August 11, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28806859/analysis-of-low-molecular-weight-compounds-using-maldi-and-ldi-tof-ms-direct-detection-of-active-pharmaceutical-ingredients-in-different-formulations
#4
João L Bronzel, Cintia D F Milagre, Humberto M S Milagre
Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) is a high throughput, easy to use analytical technique. The simple sample preparation of this technique and its tolerance to the presence of contaminants are among its advantages. In contrast, depending on the matrix used, MALDI can ionize and generates ions in the low m/z range that complicate the interpretation of the spectra of low molecular weight compounds. To address this issue, one can envisage the use of tunable ionic matrices that can reduce the low m/z interferents...
August 14, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28805873/emission-color-tuning-of-core-shell-upconversion-nanoparticles-through-modulation-of-laser-power-or-temperature
#5
Qiyue Shao, Gongtuo Zhang, Lilai Ouyang, Yanqing Hu, Yan Dong, Jianqing Jiang
Upconversion nanoparticles (UCNPs) are an excellent choice to construct security features against counterfeiting, owing to their unique NIR-to-VIS upconversion luminescence (UCL) characteristics. However, the application of upconversion materials is limited, due to their single and invariant emission colors. Herein, the temperature-dependent UCL properties of NaGdF4:Yb/Ho (or Tm) UCNPs in the solid state have been investigated. An anomalous UCL enhancement at higher temperatures has been demonstrated for these small-sized (<10 nm) UCNPs and the underlying mechanism is discussed herein...
August 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/28801849/bevacizumab-in-colorectal-cancer-current-role-in-treatment-and-the-potential-of-biosimilars
#6
REVIEW
Lee S Rosen, Ira A Jacobs, Ronald L Burkes
Colorectal cancer (CRC) is a leading cause of tumor-related morbidity and mortality worldwide, with mortality most often attributable to metastatic disease. Bevacizumab, a humanized monoclonal antibody targeting vascular endothelial growth factor, has a significant role in the treatment of metastatic CRC (mCRC). However, patient access to bevacizumab may be limited in some regions or circumstances, owing to factors related to insurance coverage, reimbursement, patient out-of-pocket costs, or availability. As a result, outcomes for patients with mCRC may be worsened...
August 11, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28800550/protein-based-medicines-analysis-by-raman-spectroscopy-for-the-detection-of-counterfeits
#7
Klara Dégardin, Anne Desponds, Yves Roggo
Protein-based medicines, or large molecule medicines, are innovative products used to treat various diseases like hepatitis or cancer. This new generation of molecules are usually expensive, and thus represents an attractive target for the counterfeiters. Due to the complexity of their chemical structure, their analysis for counterfeit detection is more difficult than small molecule medicines. The aim of the article is to demonstrate that Raman spectroscopy and microscopy can be used for the fast analysis of counterfeits of protein-based medicines...
July 20, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28790061/online-pharmacy-still-open-despite-counterfeit-allegations
#8
Lauren Vogel
No abstract text is available yet for this article.
August 8, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28764033/genetic-and-geochemical-signatures-to-prevent-frauds-and-counterfeit-of-high-quality-asparagus-and-pistachio
#9
Carmela Zannella, Francesca Carucci, Riccardo Aversano, Thomas Prohaska, Simona Vingiani, Domenico Carputo, Paola Adamo
A fingerprinting strategy based on genetic (simple sequence repeat) and geochemical (multielement and (87)Sr/(86)Sr ratio) analysis was tested to prove the geographical origin of high-quality Italian products "White Asparagus from Bassano del Grappa" and "Green Pistachio from Bronte". Genetic analysis generated many polymorphic alleles and different specific amplified fragments in both agriproducts. In addition, a core set of markers was defined. According to variability within production soils and products, potential candidate elements linking asparagus (Zn, P, Cr, Mg, B, K) and pistachio (Mn, P, Cr, Mg, Ti, B, K, Sc, S) to the production areas were identified...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28763950/paper-spray-mass-spectrometry-and-chemometric-tools-for-a-fast-and-reliable-identification-of-counterfeit-blended-scottish-whiskies
#10
Janaína Aparecida Reis Teodoro, Hebert Vinicius Pereira, Marcelo Martins Sena, Evandro Piccin, Jorge Jardim Zacca, Rodinei Augusti
A direct method based on the application of paper spray mass spectrometry (PS-MS) combined with a chemometric supervised method (partial least square discriminant analysis, PLS-DA) was developed and applied to the discrimination of authentic and counterfeit samples of blended Scottish whiskies. The developed methodology employed the negative ion mode MS, included 44 authentic whiskies from diverse brands and batches and 44 counterfeit samples of the same brands seized during operations of the Brazilian Federal Police, totalizing 88 samples...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28738623/analysis-of-illegal-peptide-drugs-via-hilic-dad-ms
#11
Steven Janvier, Evelien De Sutter, Evelien Wynendaele, Bart De Spiegeleer, Celine Vanhee, Eric Deconinck
Biopharmaceuticals have established themselves as highly efficient medicines, and are still one of the fastest growing parts of the health-product industry. Unfortunately, the introduction of these promising new drugs went hand in hand with the creation of a black market for illegal and counterfeit biotechnology drugs. Particularly popular are the lyophilised peptides with a molecular weight of less than 5kDa. Most of them are meant for subcutaneous injection and are easily accessible via the internet. In recent years, different methods based on reversed phase liquid chromatography have been developed to detect and quantify these peptides...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28731355/luminescent-fire-resistant-and-water-proof-ultralong-hydroxyapatite-nanowire-based-paper-for-multimode-anticounterfeiting-applications
#12
Ri-Long Yang, Ying-Jie Zhu, Fei-Fei Chen, Li-Ying Dong, Zhi-Chao Xiong
Counterfeiting of valuable certificates, documents, and banknotes is a serious issue worldwide. As a result, the need for developing novel anticounterfeiting materials is greatly increasing. Herein, we report a new kind of ultralong hydroxyapatite nanowire (HAPNW)-based paper with luminescence, fire resistance, and waterproofness properties that may be exploited for anticounterfeiting applications. In this work, lanthanide-ion-doped HAPNWs (HAPNW:Ln(3+)) with lengths over 100 μm have been synthesized and used as a raw material to fabricating a free-standing luminescent, fire-resistant, water-proof paper through a simple vacuum filtration process...
July 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28724837/chemical-analysis-of-counterfeit-hepatitis-c-drug-found-in-japan
#13
Nahoko Uchiyama, Hiroyuki Kamakura, Sayaka Masada, Takashi Tsujimoto, Junko Hosoe, Hiroko Tokumoto, Takuro Maruyama, Yukihiro Goda, Takashi Hakamatsuka
<bibitem lang="en">  In January 2017, counterfeits of the hepatitis C drug 'HARVONI(®) Combination Tablets' (HARVONI(®)) were found at a pharmacy chain through unlicensed suppliers in Japan. A total of five lots of counterfeit HARVONI(®) (samples 1-5) bottles were found, and the ingredients of the bottles were all in tablet form. Among them, two differently shaped tablets were present in two of the bottles (categorized as samples 2A, 2B, 4A, and 4B). We analyzed the total of seven samples by high-resolution LC-MS, GC-MS and NMR...
July 19, 2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28721965/the-rise-of-global-health-diplomacy-an-interdisciplinary-concept-linking-health-and-international-relations
#14
Vijay Kumar Chattu
Global health diplomacy (GHD) is relatively a very new field that has yet to be clearly defined and developed though there are various definitions given by different experts from foreign policy, global health, diplomacy, international relations, governance, and law. With the intensification of globalization and increasing gaps between countries, new and reemerging health threats such as HIV/AIDS, tuberculosis, influenza, severe acute respiratory syndrome, Ebola, and Zika and a gradual rethinking on security concepts framed a new political context...
April 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28721735/dynamic-color-displays-using-stepwise-cavity-resonators
#15
Yiqin Chen, Xiaoyang Duan, Marcus Matuschek, Yanming Zhou, Frank Neubrech, Huigao Duan, Na Liu
High-resolution multicolor printing based on pixelated optical nanostructures is of great importance for promoting advances in color display science. So far, most of the work in this field has been focused on achieving static colors, limiting many potential applications. This inevitably calls for the development of dynamic color displays with advanced and innovative functionalities. In this Letter, we demonstrate a novel dynamic color printing scheme using magnesium-based pixelated Fabry-Pérot cavities by gray scale nanolithography...
August 1, 2017: Nano Letters
https://www.readbyqxmd.com/read/28714695/double-protected-all-inorganic-perovskite-nanocrystals-by-crystalline-matrix-and-silica-for-triple-modal-anti-counterfeiting-codes
#16
Leimeng Xu, Jiawei Chen, Jizhong Song, Jianhai Li, Jie Xue, Yuhui Dong, Bo Cai, Qingsong Shan, Boning Han, Haibo Zeng
Novel fluorescence with highly covert and reliable features is quite desirable to combat the sophisticated counterfeiters. Herein, we report a simultaneously triple-modal fluorescent characteristic of CsPbBr3@Cs4PbBr6/SiO2 by the excitation of thermal, ultraviolet (UV) and infrared (IR) light for the first time, which can be applied for the multiple modal anti-counterfeiting codes. The diphasic structure CsPbBr3@Cs4PbBr6 nanocrystals (NCs) was synthesized via the typical reprecipitation method followed by uniformly encapsulation into silica microspheres...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28700105/dante-s-inferno-canto-xxx-imaginary-or-real-liver-disease
#17
Luigi Roffi
This image (Figure 1) shows a glimpse of Hell (Divine Comedy), when Dante Alighieri encounters Master Adam (who, having counterfeited the Florentine money, was burned at the stake in Florence in 1281), and Sinon (who tricked the Trojans with the wooden horse filled with Achaean warriors). Master Adam, an Englishman (magistro Adam de Anglia) (1) has the shape of a lute, a rotting face, and an abdomen bloated by a disease called 'dropsy' ("…And one I saw, who like a lute were shaped / if he had only had his groin cut off / down in the region where a man is forked / The heavy dropsy which unmates the limbs / in such a way with ill-digested humor / that face and paunch no longer correspond…/ Divine Comedy, Inferno XXX, 49-54) (2)...
July 12, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28693488/donor-support-for-quality-assurance-and-pharmacovigilance-of-anti-malarials-in-malaria-endemic-countries
#18
Stephanie D Kovacs, Brianna M Mills, Andy Stergachis
BACKGROUND: Malaria control efforts have been strengthened by funding from donor groups and government agencies. The Global Fund to Fight AIDS, Tuberculosis and the Malaria (Global Fund), the US President's Malaria Initiative (PMI) account for the majority of donor support for malaria control and prevention efforts. Pharmacovigilance (PV), which encompasses all activities relating to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problem, is a necessary part of efforts to reduce drug resistance and improve treatment outcomes...
July 11, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28693480/utility-preserving-anonymization-for-health-data-publishing
#19
Hyukki Lee, Soohyung Kim, Jong Wook Kim, Yon Dohn Chung
BACKGROUND: Publishing raw electronic health records (EHRs) may be considered as a breach of the privacy of individuals because they usually contain sensitive information. A common practice for the privacy-preserving data publishing is to anonymize the data before publishing, and thus satisfy privacy models such as k-anonymity. Among various anonymization techniques, generalization is the most commonly used in medical/health data processing. Generalization inevitably causes information loss, and thus, various methods have been proposed to reduce information loss...
July 11, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28663784/the-internet-trade-of-counterfeit-spirits-in-russia-an-emerging-problem-undermining-alcohol-public-health-and-youth-protection-policies
#20
Maria Neufeld, Dirk W Lachenmeier, Stephan G Walch, Jürgen Rehm
Counterfeit alcohol belongs to the category of unrecorded alcohol not reflected in official statistics. The internet trade of alcoholic beverages has been prohibited by the Russian Federation since 2007, but various sellers still offer counterfeit spirits (i.e., forged brand spirits) over the internet to Russian consumers, mostly in a non-deceptive fashion at prices up to 15 times lower than in regular sale. The public health issues arising from this unregulated trade include potential harm to underage drinkers, hazards due to toxic ingredients such as methanol, but most importantly alcohol harms due to potentially increased drinking volumes due to low prices and high availability on the internet...
2017: F1000Research
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