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https://www.readbyqxmd.com/read/28335453/a-spatially-offset-raman-spectroscopy-method-for-non-destructive-detection-of-gelatin-encapsulated-powders
#1
Kuanglin Chao, Sagar Dhakal, Jianwei Qin, Yankun Peng, Walter F Schmidt, Moon S Kim, Diane E Chan
Non-destructive subsurface detection of encapsulated, coated, or seal-packaged foods and pharmaceuticals can help prevent distribution and consumption of counterfeit or hazardous products. This study used a Spatially Offset Raman Spectroscopy (SORS) method to detect and identify urea, ibuprofen, and acetaminophen powders contained within one or more (up to eight) layers of gelatin capsules to demonstrate subsurface chemical detection and identification. A 785-nm point-scan Raman spectroscopy system was used to acquire spatially offset Raman spectra for an offset range of 0 to 10 mm from the surfaces of 24 encapsulated samples, using a step size of 0...
March 18, 2017: Sensors
https://www.readbyqxmd.com/read/28327479/finger-printing-of-counterfeit-bevacizumab-and-identifying-it-before-clinical-use
#2
Thirumurthy Velpandian, Madhu Nath, Moksha Laxmi, Nabanita Halder
BACKGROUND: Bevacizumab is widely used for ophthalmic purposes. Recently, counterfeit bevacizumab has become a matter of concern. We analysed samples of suspected counterfeit formulations of bevacizumab and assessed the possibility of using simple tests in the clinic by ophthalmologists to prevent the use of counterfeit preparations in patients. METHODS: We did a protein analysis using Bradford assay and SDS-PAGE to confirm the presence of bevacizumab in 16 samples - 6 suspected and 10 others...
November 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/28325576/raman-spectroscopy-in-quality-control-of-chinese-herbal-medicine
#3
Dan-Dan Chen, Xiao-Fang Xie, Hui Ao, Ji-Lei Liu, Cheng Peng
BACKGROUND: Chinese herbal medicine (CHM) is of noteworthy international interest due to its potential impact on healthcare and manifests numerous opportunities for new drug development. However, solid scientific evidence is still lacking regarding the safety, efficacy, and quality of CHM-derived medicines. Success in the modernization and globalization of CHM is heavily dependent on the achievements in advanced analytical techniques for in-line checks of CHM quality. Raman spectroscopy has become increasingly valued as an analytical technique in the pharmaceutical sector because it can provide a detailed chemical fingerprint...
March 16, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28314392/combining-simplicity-with-cost-effectiveness-investigation-of-potential-counterfeit-of-proton-pump-inhibitors-through-simulated-formulations-using-thin-layer-chromatography
#4
Nejal M Bhatt, Vijay D Chavada, Mallika Sanyal, Pranav S Shrivastav
A simple, accurate and precise high-performance thin-layer chromatographic method has been developed and validated for the analysis of proton pump inhibitors (PPIs) and their co-formulated drugs, available as binary combination. Planar chromatographic separation was achieved using a single mobile phase comprising of toluene: iso-propranol: acetone: ammonia 5.0:2.3:2.5:0.2 (v/v/v/v) for the analysis of 14 analytes on aluminium-backed layer of silica gel 60 FG254. Densitometric determination of the separated spots was done at 290nm...
November 18, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28283518/simultaneous-decolorization-and-biohydrogen-production-from-xylose-by-klebsiella-oxytoca-gs-4-08-in-presence-of-azo-dyes-with-sulfonate-and-carboxyl-groups
#5
Lei Yu, Ming-Yue Cao, Peng-Tao Wang, Shi Wang, Ying-Rong Yue, Wen-Duo Yuan, Wei-Chuan Qiao, Fei Wang, Xin Song
Biohydrogen production from the pulp and paper effluent containing rich lignocellulosic material could be achieved by the fermentation process. Xylose, an important hemicellulose hydrolysis product, is used less efficiently as a substrate for biohydrogen production. Moreover, azo dyes are usually added to fabricate anti-counterfeiting paper, which further increases the complexity of wastewater. This study is the first paper to report that xylose could serve as the sole carbon source for a pure culture-Klebsiella oxytoca GS-4-08 to achieve simultaneous decolorization and biohydrogen production...
March 10, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28258984/application-of-design-space-optimization-strategy-to-the-development-of-lc-methods-for-simultaneous-analysis-of-18-antiretroviral-medicines-and-4-major-excipients-used-in-various-pharmaceutical-formulations
#6
Védaste Habyalimana, Jérémie Kindenge Mbinze, Achille Loconon Yemoa, Christelle Waffo, Tidiane Diallo, Nicodème Kalenda Tshilombo, Justin-Léonard Kadima Ntokamunda, Pierre Lebrun, Philippe Hubert, Roland Djang'eing'a Marini
As one of the world's most significant public health challenges in low- and middle-income countries, HIV/AIDS deserves to be treated with appropriate medicines, however which are not spared from counterfeiting. For that, we developed screening and specific HPLC methods that can analyze 18 antiretroviral medicines (ARV) and 4 major excipients. Design of experiments and design space methodology were initially applied for 15 ARV and the 4 excipients with prediction thanks to Monte Carlo simulations and focusing on rapidity and affordability thus using short column and low cost organic solvent (methanol) in gradient mode with 10mM buffer solutions of ammonium hydrogen carbonate...
February 24, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28248033/-contemporary-aspects-of-using-sildenafil
#7
E A Efremov, E V Kasatonova, Ya I Melnik, V V Simakov
Sildenafil has been thoroughly studied in 74 registered double-blind, placebo-controlled clinical trials assessing the efficacy and safety of the drug in a total of more than 16 000 men with erectile dysfunction (ED). However, practicing urologists have some questions regarding administering the drug in patients with multiple comorbidities. In this review, on a par with the now "classic" research, we outline the latest updates of meta-analyzes and comparative studies relating to the use of sildenafil in different groups of patients...
November 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28247191/a-lc-ms-all-in-one-workflow-for-site-specific-location-identification-and-quantification-of-n-o-glycosylation-in-human-chorionic-gonadotropin-drug-products
#8
Hongbin Zhu, Chen Qiu, Ashley C Ruth, David A Keire, Hongping Ye
Site-specific characterization of the N- and O-linked glycosylation on a set of different human chorionic gonadotropin (hCG) drug products was performed by a LC-MS method combining high resolution (120K at m/z 200) mass spectrometry, multiple dissociation methods, tandem mass tag (TMT 10plex) labeling, and partial least squares-discriminant analysis (PLS-DA). In total, the data provided identification, relative quantification, and comparison of site-specific glycosylation of protein therapeutics with a single experiment...
February 28, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28239915/rapid-analysis-of-corni-fructus-using-paper-spray-mass-spectrometry
#9
Yuan Guo, Zhixin Gu, Xuemei Liu, Jingjing Liu, Ming Ma, Bo Chen, Liping Wang
INTRODUCTION: Paper spray-mass spectrometry (PS-MS) is a kind of ambient MS technique for the rapid analysis of samples. Corni fructus has been widely used in traditional Chinese compound preparations and healthy food. However, a number of counterfeits of Corni fructus, such as Crataegi fructus, Lycii fructus, and grape skin are illegally sold in crude herb markets. Therefore, the development of a rapid and high-throughput quality evaluation method is important for ensuring the effectiveness and safety of the crude materials of Corni fructus...
February 26, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28239704/a-neutral-dinuclear-ir-iii-complex-for-anti-counterfeiting-and-data-encryption
#10
Yang Jiang, Guangfu Li, Weilong Che, Yingjie Liu, Bin Xu, Guogang Shan, Dongxia Zhu, Zhongmin Su, Martin R Bryce
A neutral dinuclear Ir(iii) Schiff base complex PIBIP has been synthesized and shown to exhibit both piezochromic luminescence (PCL) and aggregation induced emission (AIE) behaviour. An efficient second-level anti-counterfeit trademark and a data encryption device were fabricated using PIBIP as the active material.
February 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28222488/explaining-counterfeit-alcohol-purchases-in-russia
#11
Zoya Kotelnikova
BACKGROUND: Alcohol is a common target of counterfeiting in Russia. Counterfeit alcohol is defined here as the manufacture, distribution, unauthorized placement (forgery) of protected commodity trademarks, and infringement of the exclusive rights of the registered trademark holders of alcoholic beverages. It is often argued that the expansion of the counterfeit product market is due to the steady demand of economically disadvantaged people for low-priced goods. The situation becomes more complicated once deceptive and nondeceptive forms of counterfeiting are taken into account...
February 21, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28217446/the-dangers-of-sexual-enhancement-supplements-and-counterfeit-drugs-to-treat-erectile-dysfunction
#12
REVIEW
Jason Chiang, Faysal A Yafi, Philip J Dorsey, Wayne J G Hellstrom
Counterfeit phosphodiesterase-5 inhibitors (PDE-5i) are an increasing problem. Already in widespread use, the market for PDE-5i is steadily growing as the population ages. Counterfeiters are taking advantage of this growing market by developing illicit and counterfeit PDE-5i products. Many factors are contributing to the rapid growth of the illicit market, such as the low risk of prosecution, potentially high financial reward, and ease of distribution via Internet pharmacies. Consumers of illicit PDE-5i often do not realize they are using counterfeit products and placing themselves at an unnecessary health risk...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28208733/a-survey-on-banknote-recognition-methods-by-various-sensors
#13
REVIEW
Ji Woo Lee, Hyung Gil Hong, Ki Wan Kim, Kang Ryoung Park
Despite a decrease in the use of currency due to the recent growth in the use of electronic financial transactions, real money transactions remain very important in the global market. While performing transactions with real money, touching and counting notes by hand, is still a common practice in daily life, various types of automated machines, such as ATMs and banknote counters, are essential for large-scale and safe transactions. This paper presents studies that have been conducted in four major areas of research (banknote recognition, counterfeit banknote detection, serial number recognition, and fitness classification) in the accurate banknote recognition field by various sensors in such automated machines, and describes the advantages and drawbacks of the methods presented in those studies...
February 8, 2017: Sensors
https://www.readbyqxmd.com/read/28205640/quantitative-bioassay-to-identify-antimicrobial-drugs-through-drug-interaction-fingerprint-analysis
#14
Zohar B Weinstein, Muhammad H Zaman
Drug interaction analysis, which reports the extent to which the presence of one drug affects the efficacy of another, is a powerful tool to select potent combinatorial therapies and predict connectivity between cellular components. Combinatorial effects of drug pairs often vary even for drugs with similar mechanism of actions. Therefore, drug interaction fingerprinting may be harnessed to differentiate drug identities. We developed a method to analyze drug interactions for the application of identifying active pharmaceutical ingredients, an essential step to assess drug quality...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28186524/anti-counterfeiting-patterns-encrypted-with-multi-mode-luminescent-nanotaggants
#15
Tianying Sun, Bingzhe Xu, Bing Chen, Xian Chen, Mingyu Li, Peng Shi, Feng Wang
Anti-counterfeiting patterns are encrypted with nanotaggants that are selectively excited at distinct wavelengths. Decryption is realized by examining the temporal color or graphic responses of the pattern under various illumination wavelengths. The covert color and graphic codes that are designable through control of the nanotaggant composition are expected to provide high-level security.
February 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28159641/microflow-imaging-analyses-reflect-mechanisms-of-aggregate-formation-comparing-protein-particle-data-sets-using-the-kullback-leibler-divergence
#16
Nathaniel R Maddux, Austin L Daniels, Theodore W Randolph
Subvisible particles in therapeutic protein formulations are an increasing manufacturing and regulatory concern because of their potential to cause adverse immune responses. Flow imaging microscopy is used extensively to detect subvisible particles and investigate product deviations, typically by comparing imaging data using histograms of particle descriptors. Such an approach discards much information and requires effort to interpret differences, which is problematic when comparing many data sets. We propose to compare imaging data using the Kullback-Leibler divergence, an information theoretic measure of the difference of distributions (Kullback S, Leibler RA...
February 1, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28157916/demonstration-of-patterned-polymer-stabilized-cholesteric-liquid-crystal-textures-for-anti-counterfeiting-two-dimensional-barcodes
#17
Wen-Song Li, Yuan Shen, Zhi-Jie Chen, Qian Cui, Sen-Sen Li, Lu-Jian Chen
We evaluated the feasibility of embedding periodically arranged squares with planar and vertical texture into a background with a developable-modulation (DM) type cholesteric liquid crystal (CLC) fingerprint texture by a two-step ultraviolet-induced polymerization method. Checker-patterned optical diffractive elements, which can be seen as a variation of a two-dimensional (2D) barcode, were first realized and the dependence of diffraction behaviors on incident light polarization and applied voltage were investigated...
January 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28156209/qualitative-and-semiquantitative-analysis-of-doping-products-seized-at-the-swiss-border
#18
Christina Weber, Oliver Krug, Matthias Kamber, Mario Thevis
BACKGROUND: Substances developed for therapeutic use are also known to be misused by athletes as doping agents and, outside of regulated sport, for image-enhancement. This has generated a market for counterfeit doping substances. Counterfeit doping agents may be of poor pharmaceutical quality and therefore constitute health risks to consumers. OBJECTIVES: This study aims to investigate the pharmaceutical quality of 1,190 doping products seized at the Swiss border...
February 3, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28153309/performance-of-nir-handheld-spectrometers-for-the-detection-of-counterfeit-tablets
#19
Aurélie Guillemain, Klara Dégardin, Yves Roggo
Near Infrared (NIR) spectroscopy is an attractive tool for pharmaceutical analyses. While lab spectrometers are very performant, they are expensive and due to their size, not adapted for field analyses. In this study, two handheld NIR spectrometers have been evaluated for the fast detection of counterfeits of pharmaceutical tablets: one low cost sensor providing a short wavelength NIR range (swNIR) and one handheld spectrometer providing a classical NIR range (cNIR). A large database containing almost all the tablets produced by the firm was created on each spectrometer...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28151981/optical-measurements-of-paintings-and-the-creation-of-an-artwork-database-for-authenticity
#20
Seonhee Hwang, Hyerin Song, Soon-Woo Cho, Chang Eun Kim, Chang-Seok Kim, Kyujung Kim
Paintings have high cultural and commercial value, so that needs to be preserved. Many techniques have been attempted to analyze properties of paintings, including X-ray analysis and optical coherence tomography (OCT) methods, and enable conservation of paintings from forgeries. In this paper, we suggest a simple and accurate optical analysis system to protect them from counterfeit which is comprised of fiber optics reflectance spectroscopy (FORS) and line laser-based topographic analysis. The system is designed to fully cover the whole area of paintings regardless of its size for the accurate analysis...
2017: PloS One
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