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https://www.readbyqxmd.com/read/28432962/gc-ms-quantitative-analysis-of-black-market-pharmaceutical-products-containing-anabolic-androgenic-steroids-seized-by-the-brazilian-federal-police
#1
Diana Brito da Justa Neves, Eloisa Dutra Caldas
The use of counterfeit or substandard medicines can have an important health impact, resulting in therapeutic failure, be toxic or even cause death. Anabolic steroids are a frequent target for counterfeiters worldwide, being the second most frequent counterfeited class in Brazil. The aims of this work were to optimize and validate a GC-MS method for the quantitative determination of anabolic steroids in tablet, aqueous suspension and oil solution forms, and to analyze pharmaceutical products sent to Brazilian Federal Police (BFP) for forensic analysis...
April 5, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28409930/ultrathin-nonlinear-metasurface-for-optical-image-encoding
#2
Felicitas Walter, Guixin Li, Cedrik Meier, Shuang Zhang, Thomas Zentgraf
Security of optical information is of great importance in modern society. Many cryptography techniques based on classical and quantum optics have been widely explored in the linear optical regime. Nonlinear optical encryption, in which encoding and decoding involve nonlinear frequency conversions, represents a new strategy for securing optical information. Here, we demonstrate that an ultrathin nonlinear photonic metasurface, consisting of meta-atoms with three-fold rotational symmetry, can be used to hide optical images under illumination with a fundamental wave...
April 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28394563/unclonable-security-codes-designed-from-multicolor-luminescent-lanthanide-doped-y2o3-nanorods-for-anticounterfeiting
#3
Pawan Kumar, Kanika Nagpal, Bipin Kumar Gupta
The duplicity of important documents has emerged as a serious problem worldwide. Therefore, many efforts have been devoted to developing easy and fast anticounterfeiting techniques with multicolor emission. Herein, we report the synthesis of multicolor luminescent lanthanide-doped Y2O3 nanorods by hydrothermal method and their usability in designing of unclonable security codes for anticounterfeiting applications. The spectroscopic features of nanorods are probed by photoluminescence spectroscopy. The Y2O3:Eu(3+), Y2O3:Tb(3+), and Y2O3:Ce(3+) nanorods emit hypersensitive red (at 611 nm), strong green (at 541 nm), and bright blue (at 438 nm) emissions at 254, 305, and 381 nm, respectively...
April 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28393531/classification-of-ciprofloxacin-tablets-using-near-infrared-spectroscopy-and-chemometric-modeling
#4
Nathan Fuenffinger, Sergey Arzhantsev, Connie Gryniewicz-Ruzicka
Exposure to unknown, mislabeled, and counterfeit pharmaceutical products is a worldwide problem that presents a serious risk to public health. Near-infrared (NIR) spectroscopy can serve as a useful tool for screening pharmaceuticals in a rapid and cost-effective manner to ensure that drug products are safe and effective. By applying chemometric techniques to NIR spectra from finished products in tablet form, minor spectral differences are discoverable, even in instances where the tablets being evaluated contain the same active pharmaceutical ingredients (APIs)...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28387134/a-rapid-identification-method-for-calamine-using-near-infrared-spectroscopy-based-on-multi-reference-correlation-coefficient-method-and-back-propagation-artificial-neural-network
#5
Yangbo Sun, Long Chen, Bisheng Huang, Keli Chen
As a mineral, the traditional Chinese medicine calamine has a similar shape to many other minerals. Investigations of commercially available calamine samples have shown that there are many fake and inferior calamine goods sold on the market. The conventional identification method for calamine is complicated, therefore as a result of the large scale of calamine samples, a rapid identification method is needed. To establish a qualitative model using near-infrared (NIR) spectroscopy for rapid identification of various calamine samples, large quantities of calamine samples including crude products, counterfeits and processed products were collected and correctly identified using the physicochemical and powder X-ray diffraction method...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28376825/antiretroviral-therapy-supply-chain-quality-control-and-assurance-in-improving-people-living-with-hiv-therapeutic-outcomes-in-cameroon
#6
M P Ngogang Djobet, David Singhe, Julienne Lohoue, Christopher Kuaban, Jeanne Ngogang, Ernest Tambo
BACKGROUND: Evaluation of medication efficacy and safety is an essential guarantee to successful therapeutic outcome in public health practices. However, larger distribution chain supply in developing countries such as Cameroon is often challenged by counterfeit drugs, poor manufacturing, storage and degradation leading to health and patient adverse consequences. Yet, access to supply chain management in strengthening ARVs quality assurance and outcomes remains poorly documented. More than 53,000 patients have been enrolled on free ARVs medications, but little is documented on quality assurance and validity of safety for affected populations along the supply chain management since 2008...
April 4, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28372157/discrimination-of-whisky-brands-and-counterfeit-identification-by-uv-vis-spectroscopy-and-multivariate-data-analysis
#7
Angélica Rocha Martins, Márcio Talhavini, Maurício Leite Vieira, Jorge Jardim Zacca, Jez Willian Batista Braga
The discrimination of whisky brands and counterfeit identification were performed by UV-Vis spectroscopy combined with partial least squares for discriminant analysis (PLS-DA). In the proposed method all spectra were obtained with no sample preparation. The discrimination models were built with the employment of seven whisky brands: Red Label, Black Label, White Horse, Chivas Regal (12years), Ballantine's Finest, Old Parr and Natu Nobilis. The method was validated with an independent test set of authentic samples belonging to the seven selected brands and another eleven brands not included in the training samples...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28370721/detection-and-imaging-of-thermochromic-ink-compounds-in-erasable-pens-using-desorption-electrospray-ionization-mass-spectrometry-desi-ms
#8
Amin Khatami, Shamina S Prova, Aafreen Bagga, Michelle Ting, Gurnoor Brar, Demian R Ifa
RATIONALE: Thermochromic ink pens are widely accessible worldwide and have gained popularity among the general public. These pens are very useful to undo mistakes while writing important documents or exams. They are also, however, extensively misused in committing crimes such as counterfeiting checks or wills. Thus, the forensics community is in need of techniques that will allow these forgeries to be detected rapidly, reliably and conveniently. METHODS: Thermochromic ink compounds were investigated using Desorption Electrospray Ionization (DESI) coupled with an LTQ mass spectrometer and Thin Layer Chromatography (TLC)...
March 30, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28366594/opportunities-for-collaboration-at-the-interface-of-pharmacovigilance-and-manufacturing
#9
Paul Beninger
A case can be made that much common ground exists between pharmacovigilance and pharmaceutical manufacturing. Of the 8 major US statutes that shaped the pharmaceutical industry since early in the 20th Century, 7 followed fatally catastrophic events related to the use of a manufactured product, and 1 followed the discovery of a counterfeit product. To facilitate an understanding of the interplay between pharmacovigilance and manufacturing, it is convenient to divide manufacturing into 3 categories: (1) upstream sourcing of materials: pharmacovigilance plays an important role when adverse event clusters are seen during routine vigilance detection processes and the suspicion turns to possibly contaminated source material, (2) the manufacturing process itself: pharmacovigilance may be called on to conduct a health hazard evaluation if a manufacturing deviation is detected after product release (the assessment can inform the depth of a recall), and (3) downstream distribution and product use: there is only light regulation of the interval between product distribution after manufacturing release and just before administration to patients, a time during which product may be subject to an out-of-specification determination for environmental controls or subject to malfeasant activities, such as counterfeit substitution or product diversion...
March 30, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28349715/a-review-of-existing-and-emerging-digital-technologies-to-combat-the-global-trade-in-fake-medicines
#10
Tim K Mackey, Gaurvika Nayyar
The globalization of the pharmaceutical supply chain has introduced new challenges, chief among them, fighting the international criminal trade in fake medicines. As the manufacture, supply, and distribution of drugs becomes more complex, so does the need for innovative technology-based solutions to protect patients globally. Areas covered: We conducted a multidisciplinary review of the science/health, information technology, computer science, and general academic literature with the aim of identifying cutting-edge existing and emerging 'digital' solutions to combat fake medicines...
April 7, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28335453/a-spatially-offset-raman-spectroscopy-method-for-non-destructive-detection-of-gelatin-encapsulated-powders
#11
Kuanglin Chao, Sagar Dhakal, Jianwei Qin, Yankun Peng, Walter F Schmidt, Moon S Kim, Diane E Chan
Non-destructive subsurface detection of encapsulated, coated, or seal-packaged foods and pharmaceuticals can help prevent distribution and consumption of counterfeit or hazardous products. This study used a Spatially Offset Raman Spectroscopy (SORS) method to detect and identify urea, ibuprofen, and acetaminophen powders contained within one or more (up to eight) layers of gelatin capsules to demonstrate subsurface chemical detection and identification. A 785-nm point-scan Raman spectroscopy system was used to acquire spatially offset Raman spectra for an offset range of 0 to 10 mm from the surfaces of 24 encapsulated samples, using a step size of 0...
March 18, 2017: Sensors
https://www.readbyqxmd.com/read/28327479/finger-printing-of-counterfeit-bevacizumab-and-identifying-it-before-clinical-use
#12
Thirumurthy Velpandian, Madhu Nath, Moksha Laxmi, Nabanita Halder
BACKGROUND: Bevacizumab is widely used for ophthalmic purposes. Recently, counterfeit bevacizumab has become a matter of concern. We analysed samples of suspected counterfeit formulations of bevacizumab and assessed the possibility of using simple tests in the clinic by ophthalmologists to prevent the use of counterfeit preparations in patients. METHODS: We did a protein analysis using Bradford assay and SDS-PAGE to confirm the presence of bevacizumab in 16 samples - 6 suspected and 10 others...
November 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/28325576/raman-spectroscopy-in-quality-control-of-chinese-herbal-medicine
#13
Dan-Dan Chen, Xiao-Fang Xie, Hui Ao, Ji-Lei Liu, Cheng Peng
BACKGROUND: Chinese herbal medicine (CHM) is of noteworthy international interest due to its potential impact on healthcare and manifests numerous opportunities for new drug development. However, solid scientific evidence is still lacking regarding the safety, efficacy, and quality of CHM-derived medicines. Success in the modernization and globalization of CHM is heavily dependent on the achievements in advanced analytical techniques for in-line checks of CHM quality. Raman spectroscopy has become increasingly valued as an analytical technique in the pharmaceutical sector because it can provide a detailed chemical fingerprint...
May 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28314392/combining-simplicity-with-cost-effectiveness-investigation-of-potential-counterfeit-of-proton-pump-inhibitors-through-simulated-formulations-using-thin-layer-chromatography
#14
Nejal M Bhatt, Vijay D Chavada, Mallika Sanyal, Pranav S Shrivastav
A simple, accurate and precise high-performance thin-layer chromatographic method has been developed and validated for the analysis of proton pump inhibitors (PPIs) and their co-formulated drugs, available as binary combination. Planar chromatographic separation was achieved using a single mobile phase comprising of toluene: iso-propranol: acetone: ammonia 5.0:2.3:2.5:0.2 (v/v/v/v) for the analysis of 14 analytes on aluminium-backed layer of silica gel 60 FG254. Densitometric determination of the separated spots was done at 290nm...
November 18, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28283518/simultaneous-decolorization-and-biohydrogen-production-from-xylose-by-klebsiella-oxytoca-gs-4-08-in-presence-of-azo-dyes-with-sulfonate-and-carboxyl-groups
#15
Lei Yu, Ming-Yue Cao, Peng-Tao Wang, Shi Wang, Ying-Rong Yue, Wen-Duo Yuan, Wei-Chuan Qiao, Fei Wang, Xin Song
Biohydrogen production from the pulp and paper effluent containing rich lignocellulosic material could be achieved by the fermentation process. Xylose, an important hemicellulose hydrolysis product, is used less efficiently as a substrate for biohydrogen production. Moreover, azo dyes are usually added to fabricate anti-counterfeiting paper, which further increases the complexity of wastewater. This study is the first paper to report that xylose could serve as the sole carbon source for a pure culture-Klebsiella oxytoca GS-4-08 to achieve simultaneous decolorization and biohydrogen production...
March 10, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28258984/application-of-design-space-optimization-strategy-to-the-development-of-lc-methods-for-simultaneous-analysis-of-18-antiretroviral-medicines-and-4-major-excipients-used-in-various-pharmaceutical-formulations
#16
Védaste Habyalimana, Jérémie Kindenge Mbinze, Achille Loconon Yemoa, Christelle Waffo, Tidiane Diallo, Nicodème Kalenda Tshilombo, Justin-Léonard Kadima Ntokamunda, Pierre Lebrun, Philippe Hubert, Roland Djang'eing'a Marini
As one of the world's most significant public health challenges in low- and middle-income countries, HIV/AIDS deserves to be treated with appropriate medicines, however which are not spared from counterfeiting. For that, we developed screening and specific HPLC methods that can analyze 18 antiretroviral medicines (ARV) and 4 major excipients. Design of experiments and design space methodology were initially applied for 15 ARV and the 4 excipients with prediction thanks to Monte Carlo simulations and focusing on rapidity and affordability thus using short column and low cost organic solvent (methanol) in gradient mode with 10mM buffer solutions of ammonium hydrogen carbonate...
May 30, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28248033/-contemporary-aspects-of-using-sildenafil
#17
E A Efremov, E V Kasatonova, Ya I Melnik, V V Simakov
Sildenafil has been thoroughly studied in 74 registered double-blind, placebo-controlled clinical trials assessing the efficacy and safety of the drug in a total of more than 16 000 men with erectile dysfunction (ED). However, practicing urologists have some questions regarding administering the drug in patients with multiple comorbidities. In this review, on a par with the now "classic" research, we outline the latest updates of meta-analyzes and comparative studies relating to the use of sildenafil in different groups of patients...
November 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28247191/a-lc-ms-all-in-one-workflow-for-site-specific-location-identification-and-quantification-of-n-o-glycosylation-in-human-chorionic-gonadotropin-drug-products
#18
Hongbin Zhu, Chen Qiu, Ashley C Ruth, David A Keire, Hongping Ye
Site-specific characterization of the N- and O-linked glycosylation on a set of different human chorionic gonadotropin (hCG) drug products was performed by a LC-MS method combining high resolution (120K at m/z 200) mass spectrometry, multiple dissociation methods, tandem mass tag (TMT 10plex) labeling, and partial least squares-discriminant analysis (PLS-DA). In total, the data provided identification, relative quantification, and comparison of site-specific glycosylation of protein therapeutics with a single experiment...
February 28, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28239915/rapid-analysis-of-corni-fructus-using-paper-spray-mass-spectrometry
#19
Yuan Guo, Zhixin Gu, Xuemei Liu, Jingjing Liu, Ming Ma, Bo Chen, Liping Wang
INTRODUCTION: Paper spray-mass spectrometry (PS-MS) is a kind of ambient MS technique for the rapid analysis of samples. Corni fructus has been widely used in traditional Chinese compound preparations and healthy food. However, a number of counterfeits of Corni fructus, such as Crataegi fructus, Lycii fructus, and grape skin are illegally sold in crude herb markets. Therefore, the development of a rapid and high-throughput quality evaluation method is important for ensuring the effectiveness and safety of the crude materials of Corni fructus...
February 26, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28239704/a-neutral-dinuclear-ir-iii-complex-for-anti-counterfeiting-and-data-encryption
#20
Yang Jiang, Guangfu Li, Weilong Che, Yingjie Liu, Bin Xu, Guogang Shan, Dongxia Zhu, Zhongmin Su, Martin R Bryce
A neutral dinuclear Ir(iii) Schiff base complex PIBIP has been synthesized and shown to exhibit both piezochromic luminescence (PCL) and aggregation induced emission (AIE) behaviour. An efficient second-level anti-counterfeit trademark and a data encryption device were fabricated using PIBIP as the active material.
February 27, 2017: Chemical Communications: Chem Comm
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