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https://www.readbyqxmd.com/read/28726056/interobserver-variability-of-patient-positioning-using-four-different-ct-datasets-for-image-registration-in-lung-stereotactic-body-radiotherapy
#1
Markus Oechsner, Barbara Chizzali, Michal Devecka, Stefan Münch, Stephanie Elisabeth Combs, Jan Jakob Wilkens, Marciana Nona Duma
PURPOSE: To assess the impact of different reference CT datasets on manual image registration with free-breathing three-dimensional (3D) cone beam CTs (FB-CBCT) for patient positioning by several observers. METHODS: For 48 patients with lung lesions, manual image registration with FB-CBCTs was performed by four observers. A slow planning CT (PCT), average intensity projection (AIP), maximum intensity projection (MIP), and midventilation CT (MidV) were used as reference images...
July 19, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28725878/segmentation-of-gliomas-in-pre-operative-and-post-operative-multimodal-magnetic-resonance-imaging-volumes-based-on-a-hybrid-generative-discriminative-framework
#2
Ke Zeng, Spyridon Bakas, Aristeidis Sotiras, Hamed Akbari, Martin Rozycki, Saima Rathore, Sarthak Pati, Christos Davatzikos
We present an approach for segmenting both low- and high-grade gliomas in multimodal magnetic resonance imaging volumes. The proposed framework is an extension of our previous work [6,7], with an additional component for segmenting post-operative scans. The proposed approach is based on a hybrid generative-discriminative model. Firstly, a generative model based on a joint segmentation-registration framework is used to segment the brain scans into cancerous and healthy tissues. Secondly, a gradient boosting classification scheme is used to refine tumor segmentation based on information from multiple patients...
October 2016: Brainlesion (2016)
https://www.readbyqxmd.com/read/28725585/a-critical-comparison-of-techniques-for-mri-targeted-biopsy-of-the-prostate
#3
REVIEW
Francesco Giganti, Caroline M Moore
MRI-targeted biopsy is a promising technique that offers an improved detection of clinically significant prostate cancer over standard non-targeted biopsy. It is established that prostate MRI is of use in both the primary and repeat biopsy setting for the detection of significant prostate cancer. There are three approaches to targeting biopsies to areas of interest seen on prostate MRI. They each rely on the acquisition and reporting of a diagnostic quality multi-parametric MRI scan used to identify areas of interest, and the subsequent use of those diagnostic quality images in combination with real-time images of the prostate during the biopsy procedure...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725582/co-registration-of-mri-and-ultrasound-accuracy-of-targeting-based-on-radiology-pathology-correlation
#4
REVIEW
Win Shun Lai, Jessica G Zarzour, Jennifer B Gordetsky, Soroush Rais-Bahrami
We reviewed the role of multiparametric magnetic resonance imaging (MP-MRI) and methods of MRI guided biopsy including in-bore, cognitive fusion, and software-based fusion. MP-MRI has been developed, optimized, and studied as a means of improving prostate cancer detection beyond the standard evaluation that utilizes digital rectal examinations and serum prostate specific antigen (PSA). MP-MRI has been proven to be an excellent diagnostic imaging modality that improves prostate cancer detection and risk stratification by guiding biopsy samples...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28721302/correlation-between-two-methods-of-florbetapir-pet-quantitative-analysis
#5
Christopher Breault, Jonathan Piper, Abhinay D Joshi, Sara D Pirozzi, Aaron S Nelson, Ming Lu, Michael J Pontecorvo, Mark A Mintun, Michael D Devous
This study evaluated performance of a commercially available standardized software program for calculation of florbetapir PET standard uptake value ratios (SUVr) in comparison with an established research method. Florbetapir PET images for 183 subjects clinically diagnosed as cognitively normal (CN), mild cognitive impairment (MCI) or probable Alzheimer's disease (AD) (45 AD, 60 MCI, and 78 CN) were evaluated using two software processing algorithms. The research method uses a single florbetapir PET template generated by averaging both amyloid positive and amyloid negative registered brains together...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28720725/optical-coherence-tomography-findings-in-patients-with-coronary-stent-thrombosis-a-report-of-the-prevention-of-late-stent-thrombosis-by-an-interdisciplinary-global-european-effort-prestige-consortium
#6
Tom Adriaenssens, Michael Joner, Thea Godschalk, Nikesh Malik, Fernando Alfonso, Erion Xhepa, Dries De Cock, Kenichi Komukai, Tomohisa Tada, Javier Cuesta, Vasile Sirbu, Laurent J Feldman, Franz-Josef Neumann, Alison H Goodall, Ton Heestermans, Ian Buysschaert, Ota Hlinomaz, Ann Belmans, Walter Desmet, Jurrien M Ten Berg, Anthony H Gershlick, Steffen Massberg, Adnan Kastrati, Giulio Guagliumi, Robert Byrne
Background -Stent thrombosis (ST) is a serious complication following coronary stenting. Intravascular optical coherence tomography (OCT) may provide insights into mechanistic processes leading to ST. We performed a prospective, multicenter study to evaluate OCT findings in patients with ST. Methods -Consecutive patients presenting with ST were prospectively enrolled in a registry using a centralized telephone registration system. After angiographic confirmation of ST, OCT imaging of the culprit vessel was performed with frequency domain OCT...
July 18, 2017: Circulation
https://www.readbyqxmd.com/read/28720724/aortic-wall-inflammation-predicts-abdominal-aortic-aneurysm-expansion-rupture-and-need-for-surgical-repair
#7
The Ma Rs Study Investigators
Background -Ultrasmall superparamagnetic particles of iron oxide (USPIO) detect cellular inflammation on magnetic resonance imaging (MRI). In patients with abdominal aortic aneurysm, we assessed whether USPIO-enhanced MRI can predict aneurysm growth rates and clinical outcomes. Methods -In a prospective multicentre open-label cohort study, 342 patients with abdominal aortic aneurysm (diameter ≥40 mm) were classified by the presence of USPIO enhancement and were monitored with serial ultrasound and clinical follow-up for at least 2 years...
July 18, 2017: Circulation
https://www.readbyqxmd.com/read/28719002/eyeslam-real-time-simultaneous-localization-and-mapping-of-retinal-vessels-during-intraocular-microsurgery
#8
Daniel Braun, Sungwook Yang, Joseph N Martel, Cameron N Riviere, Brian C Becker
BACKGROUND: Fast and accurate mapping and localization of the retinal vasculature is critical to increasing the effectiveness and clinical utility of robot-assisted intraocular microsurgery such as laser photocoagulation and retinal vessel cannulation. METHODS: The proposed EyeSLAM algorithm delivers 30 Hz real-time simultaneous localization and mapping of the human retina and vasculature during intraocular surgery, combining fast vessel detection with 2D scan-matching techniques to build and localize a probabilistic map of the vasculature...
July 18, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28718788/implementation-of-an-imu-aided-image-stacking-algorithm-in-a-digital-camera-for-unmanned-aerial-vehicles
#9
Ahmad Audi, Marc Pierrot-Deseilligny, Christophe Meynard, Christian Thom
Images acquired with a long exposure time using a camera embedded on UAVs (Unmanned Aerial Vehicles) exhibit motion blur due to the erratic movements of the UAV. The aim of the present work is to be able to acquire several images with a short exposure time and use an image processing algorithm to produce a stacked image with an equivalent long exposure time. Our method is based on the feature point image registration technique. The algorithm is implemented on the light-weight IGN (Institut national de l'information géographique) camera, which has an IMU (Inertial Measurement Unit) sensor and an SoC (System on Chip)/FPGA (Field-Programmable Gate Array)...
July 18, 2017: Sensors
https://www.readbyqxmd.com/read/28718001/a-new-device-for-fiducial-registration-of-image-guided-navigation-system-for-liver-rfa
#10
Nobutaka Doba, Hiroyuki Fukuda, Kazushi Numata, Yoshiteru Hao, Kouji Hara, Akito Nozaki, Masaaki Kondo, Makoto Chuma, Katsuaki Tanaka, Shigeo Takebayashi, Norihiro Koizumi, Akira Kobayashi, Junichi Tokuda, Shin Maeda
PURPOSE: Radiofrequency ablation for liver tumors (liver RFA) is widely performed under ultrasound guidance. However, discriminating between the tumor and the needle is often difficult because of cavitation caused by RFA-induced coagulation. An unclear ultrasound image can lead to complications and tumor residue. Therefore, image-guided navigation systems based on fiducial registration have been developed. Fiducial points are usually set on a patient's skin. But the use of internal fiducial points can improve the accuracy of navigation...
July 17, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28717124/hyper-stain-inspector-a-framework-for-robust-registration-and-localised-co-expression-analysis-of-multiple-whole-slide-images-of-serial-histology-sections
#11
Nicholas Trahearn, David Epstein, Ian Cree, David Snead, Nasir Rajpoot
In this paper, we present a fast method for registration of multiple large, digitised whole-slide images (WSIs) of serial histology sections. Through cross-slide WSI registration, it becomes possible to select and analyse a common visual field across images of several serial section stained with different protein markers. It is, therefore, a critical first step for any downstream co-localised cross-slide analysis. The proposed registration method uses a two-stage approach, first estimating a fast initial alignment using the tissue sections' external boundaries, followed by an efficient refinement process guided by key biological structures within the visual field...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716714/functional-density-and-edge-maps-characterizing-functional-architecture-in-individuals-and-improving-cross-subject-registration
#12
Tong Tong, Iman Aganj, Tian Ge, Jonathan R Polimeni, Bruce Fischl
Population-level inferences and individual-level analyses are two important aspects in functional magnetic resonance imaging (fMRI) studies. Extracting reliable and informative features from fMRI data that capture biologically meaningful inter-subject variation is critical for aligning and comparing functional networks across subjects, and connecting the properties of functional brain organization with variations in behavior, cognition and genetics. In this study, we derive two new measures, which we term functional density map and edge map, and demonstrate their usefulness in characterizing the function of individual brains...
July 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28716583/quantitative-analysis-of-geometry-and-lateral-symmetry-of-proximal-middle-cerebral-artery
#13
Roman Peter, Bart J Emmer, Adriaan C G M van Es, Theo van Walsum
BACKGROUND: The purpose of our work is to quantitatively assess clinically relevant geometric properties of proximal middle cerebral arteries (pMCA), to investigate the degree of their lateral symmetry, and to evaluate whether the pMCA can be modeled by using state-of-the-art deformable image registration of the ipsi- and contralateral hemispheres. METHODS: Individual pMCA segments were identified, quantified, and statistically evaluated on a set of 55 publicly available magnetic resonance angiography time-of-flight images...
July 14, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28715368/loading-a-calcium-dye-into-frog-nerve-endings-through-the-nerve-stump-calcium-transient-registration-in-the-frog-neuromuscular-junction
#14
Dmitry V Samigullin, Eduard F Khaziev, Nikita V Zhilyakov, Ellya A Bukharaeva, Eugeny E Nikolsky
One of the most feasible methods of measuring presynaptic calcium levels in presynaptic nerve terminals is optical recording. It is based on using calcium-sensitive fluorescent dyes that change their emission intensity or wavelength depending on the concentration of free calcium in the cell. There are several methods used to stain cells with calcium dyes. Most common are the processes of loading the dyes through a micropipette or pre-incubating with the acetoxymethyl ester forms of the dyes. However, these methods are not quite applicable to neuromuscular junctions (NMJs) due to methodological issues that arise...
July 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28714897/development-of-three-dimensional-dental-scanning-apparatus-using-structured-illumination
#15
Jae Sung Ahn, Anjin Park, Ju Wan Kim, Byeong Ha Lee, Joo Beom Eom
We demonstrated a three-dimensional (3D) dental scanning apparatus based on structured illumination. A liquid lens was used for tuning focus and a piezomotor stage was used for the shift of structured light. A simple algorithm, which detects intensity modulation, was used to perform optical sectioning with structured illumination. We reconstructed a 3D point cloud, which represents the 3D coordinates of the digitized surface of a dental gypsum cast by piling up sectioned images. We performed 3D registration of an individual 3D point cloud, which includes alignment and merging the 3D point clouds to exhibit a 3D model of the dental cast...
July 15, 2017: Sensors
https://www.readbyqxmd.com/read/28714458/a-graphical-approach-to-optimizing-variable-kernel-smoothing-parameters-for-improved-deformable-registration-of-ct-and-cone-beam-ct-images
#16
Vern Hart, Damon Burrow, X Allen Li
A systematic method is presented for determining optimal parameters in variable-kernel deformable image registration of cone beam CT and CT images, in order to improve accuracy and convergence for potential use in online adaptive radiotherapy. Assessed conditions included the noise constant (symmetric force demons), the kernel reduction rate, the kernel reduction percentage, and the kernel adjustment criteria. Four such parameters were tested in conjunction with reductions of 5, 10, 15, 20, 30, and 40%. Noise constants ranged from 1...
July 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28712282/deformable-image-registration-in-radiation-therapy
#17
REVIEW
Seungjong Oh, Siyong Kim
The number of imaging data sets has significantly increased during radiation treatment after introducing a diverse range of advanced techniques into the field of radiation oncology. As a consequence, there have been many studies proposing meaningful applications of imaging data set use. These applications commonly require a method to align the data sets at a reference. Deformable image registration (DIR) is a process which satisfies this requirement by locally registering image data sets into a reference image set...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28711582/a-novel-wnt-pathway-inhibitor-sm04690-for-the-treatment-of-moderate-to-severe-osteoarthritis-of-the-knee-results-of-a-24-week-randomized-controlled-phase-1-study
#18
Yusuf Yazici, Timothy E McAlindon, Roy Fleischmann, Allan Gibofsky, Nancy E Lane, Alan J Kivitz, Nebojsa Skrepnik, Eddie Armas, Christopher J Swearingen, Anita DiFrancesco, Jeyanesh R S Tambiah, John Hood, Marc C Hochberg
OBJECTIVE: To assess the safety, pharmacokinetics, and exploratory efficacy of SM04690, a novel Wnt pathway inhibitor, as a potential disease modifying treatment for knee OA. DESIGN: Subjects with Kellgren-Lawrence grade 2-3 knee OA were randomized in successive dose-escalation cohorts to receive a knee intra-articular injection with 0.03, 0.07, or 0.23 mg SM04690, or placebo (PBO) (4:1 ratio). Safety, pharmacokinetics, efficacy (WOMAC Total/Function/Pain, Pain VAS, Physician Global Assessment [MDGA], and OMERACT-OARSI Response), OA-related biomarker (P1NP, ß-CTX, and COMP), and radiographic/imaging data were collected at baseline and during 24-week follow-up...
July 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28711376/motor-evoked-potentials-in-patients-with-chronic-whiplash-associated-disorder-grade-ii
#19
Jacques De Reuck
BACKGROUND AND PURPOSE: It is common belief that psychological problems influence the persistence of complains in patients with so-called mild whiplash-associated disorders (WADs). The usefulness of motor evoked potentials (MEPs) is investigated in patients with grade II WAD and remaining complains for more than 6 months. PATIENTS AND METHODS: Twenty consecutive patients, aged between 24 and 58 years, with persistent neck pain for months after a car accident were included...
July 8, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28711186/megavoltage-2d-topographic-imaging-an-attractive-alternative-to-megavoltage-ct-for-the-localization-of-breast-cancer-patients-treated-with-tomodirect
#20
Philippe Meyer, Fabien Le Pennec, Susanta K Hui, Nicolas Dehaynin, Delphine Jarnet, Matthieu Gantier, Claudine Niederst, Christophe Mazzara, Etienne Baudrier, Vincent Noblet
PURPOSE: To show the usefulness of topographic 2D megavoltage images (MV2D) for the localization of breast cancer patients treated with TomoDirect (TD), a radiotherapy treatment technique with fixed-angle beams performed on a TomoTherapy system. METHODS: A method was developed to quickly localize breast cancer patients treated with TD by registering the MV2D images produced before a TD treatment with reference images reconstructed from a kilovoltage CT simulation scanner and by using the projection of the beam-eye-view TD treatment field...
July 2017: Physica Medica: PM
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