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https://www.readbyqxmd.com/read/28634219/early-use-of-n-acetylcysteine-nac-with-nitrate-therapy-in-patients-undergoing-primary-percutaneous-coronary-intervention-for-st-segment-elevation-myocardial-infarction-reduces-myocardial-infarct-size-the-naciam-trial
#1
Sivabaskari Pasupathy, Rosanna Tavella, Suchi Grover, Betty Raman, Nathan E K Procter, Yang T Du, Gnanadevan Mahadavan, Irene Stafford, Tamila Heresztyn, Andrew Holmes, Christopher Zeitz, Margaret Arstall, Joseph B Selvanayagam, John D Horowitz, John F Beltrame
Background -Contemporary ST-elevation myocardial infarction (STEMI) management involves primary percutaneous coronary intervention (PCI) with on-going studies focusing on infarct size reduction utilizing ancillary therapies. N-acetylcysteine (NAC) is an antioxidant with reactive oxygen species scavenging properties that also potentiates the effects of nitroglycerin (NTG) and thus represents a potentially beneficial ancillary therapy in primary PCI. The NACIAM (NACIn Acute Myocardial infarction) trial examined the effects of NAC on infarct size in STEMI patients undergoing PCI...
June 20, 2017: Circulation
https://www.readbyqxmd.com/read/28634148/iodine-and-freeze-drying-enhanced-high-resolution-microct-imaging-for-reconstructing-3d-intraneural-topography-of-human-peripheral-nerve-fascicles
#2
Liwei Yan, Yongze Guo, Jian Qi, Qingtang Zhu, Liqiang Gu, Canbin Zheng, Tao Lin, Yutong Yu, Zitao Zeng, Sha Yu, Shuang Zhu, Xiang Zhou, Xi Zhang, Yunfei Du, Zhi Yao, Yao Lu, Xiaolin Liu
BACKGROUND: The precise annotation and accurate identification of the topography of fascicles to the end organs are prerequisites for studying human peripheral nerves. NEW METHOD: In this study, we present a feasible imaging method that acquires 3D high-resolution (HR) topography of peripheral nerve fascicles using an iodine and freeze-drying (IFD) micro-computed tomography (microCT) method to greatly increase the contrast of fascicle images. RESULTS: The enhanced microCT imaging method can facilitate the reconstruction of high-contrast HR fascicle images, fascicle segmentation and extraction, feature analysis, and the tracing of fascicle topography to end organs, which define fascicle functions...
June 17, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28630884/evaluation-of-a-high-resolution-patient-specific-model-of-the-electrically-stimulated-cochlea
#3
Ahmet Cakir, Robert T Dwyer, Jack H Noble
Cochlear implants (CIs) are surgically implanted medical devices used to treat individuals with severe-to-profound sensorineural hearing loss. Although these devices have been remarkably successful at restoring audibility, many patients experience poor outcomes. Our group has developed the first image-guided CI programming technique where the electrode positions are found in CT images and used to estimate neural activation patterns, which is unique information that audiologists can use to define patient-specific processor settings...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28630487/multicolor-two-photon-imaging-of-endogenous-fluorophores-in-living-tissues-by-wavelength-mixing
#4
Chiara Stringari, Lamiae Abdeladim, Guy Malkinson, Pierre Mahou, Xavier Solinas, Isabelle Lamarre, Sébastien Brizion, Jean-Baptiste Galey, Willy Supatto, Renaud Legouis, Ana-Maria Pena, Emmanuel Beaurepaire
Two-photon imaging of endogenous fluorescence can provide physiological and metabolic information from intact tissues. However, simultaneous imaging of multiple intrinsic fluorophores, such as nicotinamide adenine dinucleotide(phosphate) (NAD(P)H), flavin adenine dinucleotide (FAD) and retinoids in living systems is generally hampered by sequential multi-wavelength excitation resulting in motion artifacts. Here, we report on efficient and simultaneous multicolor two-photon excitation of endogenous fluorophores with absorption spectra spanning the 750-1040 nm range, using wavelength mixing...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28628801/evaluation-of-midcarpal-capitate-contact-mechanics-in-normal-injured-and-post-operative-wrists
#5
Saman Modaresi, Madhan S Kallem, Phil Lee, Terence E McIff, E Bruce Toby, Kenneth J Fischer
BACKGROUND: Scapholunate ligament injury is a commonly occurring carpal ligament injury. Pathology associated with scapholunate ligament injury depends on several factors such as the time after injury, type of injury (instability) and the development of osteoarthritis. The aim of this study was to investigate and compare contact mechanics in the lunocapitate and scaphocapitate joints in the normal, injured (scapholunate dissociation) and repaired (postoperative) wrist. METHODS: Four human subjects with scapholunate ligament dissociation participated in this study...
June 13, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28626876/optical-molecular-imaging-guided-radiation-therapy-part-2-integrated-x-ray-and-fluorescence-molecular-tomography
#6
Junwei Shi, Thirupandiyur S Udayakumar, Zhiqun Wang, Nesrin Dogan, Alan Pollack, Yidong Yang
PURPOSE: Differentiating tumor from its surrounding soft tissues is challenging for x-ray computed tomography (CT). Fluorescence molecular tomography (FMT) can directly localize the internal tumors targeted with specific fluorescent probes. A FMT system was developed and integrated onto a CT guided irradiator to improve tumor localization for image guided radiation. METHODS: The FMT system was aligned orthogonal to the cone beam CT onboard our previously developed image guided small animal arc radiation treatment system (iSMAART)...
June 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28625473/effect-of-dir-uncertainty-on-prostate-passive-scattering-proton-therapy-dose-accumulation
#7
Yoshitomo Abe, Noriyuki Kadoya, Kazuhiro Arai, Yoshiki Takayama, Takahiro Kato, Kanako Kimura, Takashi Ono, Tatsuya Nakamura, Hitoshi Wada, Yasuhiro Kikuchi, Keiichi Jingu
Deformable image registration (DIR) is important in dose accumulation. Currently, the impact of DIR-algorithm-associated uncertainties in proton therapy is unclear. Here, we quantify the effect of DIR uncertainties on prostate passive-scattering proton therapy (PSPT) dose accumulation. Ten patients with an intermediate risk for prostate cancer formerly treated by PSPT (PTV D95=78GyE) were studied. Dose distributions from all verification CT images (five images per patient) were warped and accumulated in the planning CT geometries with DIR...
June 15, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28625472/3d-catheter-reconstruction-in-hdr-prostate-brachytherapy-for-pre-treatment-verification-using-a-flat-panel-detector
#8
Ryan L Smith, Annette Haworth, Vanessa Panettieri, Jeremy L Millar, Rick D Franich
PURPOSE: High dose rate prostate brachytherapy is a widely-practiced treatment, delivering large conformal doses in relatively few treatment fractions. Inter- and intra-fraction catheter displacements have been reported. Unrecognized displacement can have a significant impact on dosimetry. Knowledge of the implant geometry at the time of treatment is important for ensuring safe and effective treatment. In this work we demonstrate a method to reconstruct the catheter positions pre-treatment, using a 'shift' imaging technique, and perform registration with the treatment plan for verification relative to the prostate...
June 15, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28624755/stereo-vision-based-tracking-of-soft-tissue-motion-with-application-to-online-ablation-control-in-laser-microsurgery
#9
Andreas Schoob, Dennis Kundrat, Lüder A Kahrs, Tobias Ortmaier
Recent research has revealed that image-based methods can enhance accuracy and safety in laser microsurgery. In this study, non-rigid tracking using surgical stereo imaging and its application to laser ablation is discussed. A recently developed motion estimation framework based on piecewise affine deformation modeling is extended by a mesh refinement step and considering texture information. This compensates for tracking inaccuracies potentially caused by inconsistent feature matches or drift. To facilitate online application of the method, computational load is reduced by concurrent processing and affine-invariant fusion of tracking and refinement results...
June 8, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28623558/a-method-to-recognize-anatomical-site-and-image-acquisition-view-in-x-ray-images
#10
Xiao Chang, Thomas Mazur, H Harold Li, Deshan Yang
A method was developed to recognize anatomical site and image acquisition view automatically in 2D X-ray images that are used in image-guided radiation therapy. The purpose is to enable site and view dependent automation and optimization in the image processing tasks including 2D-2D image registration, 2D image contrast enhancement, and independent treatment site confirmation. The X-ray images for 180 patients of six disease sites (the brain, head-neck, breast, lung, abdomen, and pelvis) were included in this study with 30 patients each site and two images of orthogonal views each patient...
June 16, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28622410/accuracy-of-deformable-image-registration-on-magnetic-resonance-images-in-digital-and-physical-phantoms
#11
Rachel B Ger, Jinzhong Yang, Yao Ding, Megan C Jacobsen, Clifton D Fuller, Rebecca M Howell, Heng Li, R Jason Stafford, Shouhao Zhou, Laurence E Court
PURPOSE: Accurate deformable image registration is necessary for longitudinal studies. The error associated with commercial systems has been evaluated using computed tomography (CT). Several in-house algorithms have been evaluated for use with magnetic resonance imaging (MRI), but there is still relatively little information about MRI deformable image registration. This work presents an evaluation of two deformable image registration systems, one commercial (Velocity) and one in-house (demons-based algorithm), with MRI using two different metrics to quantify the registration error...
June 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/28620411/vicar-an-adaptive-and-landmark-free-registration-of-time-lapse-image-data-from-microfluidics-experiments
#12
Georges Hattab, Jan-Philip Schlüter, Anke Becker, Tim W Nattkemper
In order to understand gene function in bacterial life cycles, time lapse bioimaging is applied in combination with different marker protocols in so called microfluidics chambers (i.e., a multi-well plate). In one experiment, a series of T images is recorded for one visual field, with a pixel resolution of 60 nm/px. Any (semi-)automatic analysis of the data is hampered by a strong image noise, low contrast and, last but not least, considerable irregular shifts during the acquisition. Image registration corrects such shifts enabling next steps of the analysis (e...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28619289/validation-of-a-method-for-dose-of-the-day-calculation-in-head-neck-tomotherapy-by-using-planning-ct-to-mvct-deformable-image-registration
#13
M Branchini, C Fiorino, I Dell'Oca, M L Belli, L Perna, N Di Muzio, R Calandrino, S Broggi
PURPOSE: The aim of this study was to test the feasibility and dosimetric accuracy of a method that employs planning CT-to-MVCT deformable image registration (DIR) for calculation of the daily dose for head and neck (HN) patients treated with Helical Tomotherapy (HT). METHODS: For each patient, the planning kVCT (CTplan) was deformably registered to the MVCT acquired at the 15th therapy session (MV15) with a B-Spline Free Form algorithm using Mattes mutual information (open-source software 3D Slicer), resulting in a deformed CT (CTdef)...
June 12, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28617996/gradient-nonlinearity-effects-on-upper-cervical-spinal-cord-area-measurement-from-3d-t1-weighted-brain-mri-acquisitions
#14
Nico Papinutto, Rohit Bakshi, Antje Bischof, Peter A Calabresi, Eduardo Caverzasi, R Todd Constable, Esha Datta, Gina Kirkish, Govind Nair, Jiwon Oh, Daniel Pelletier, Dzung L Pham, Daniel S Reich, William Rooney, Snehashis Roy, Daniel Schwartz, Russell T Shinohara, Nancy L Sicotte, William A Stern, Ian Tagge, Shahamat Tauhid, Subhash Tummala, Roland G Henry
PURPOSE: To explore (i) the variability of upper cervical cord area (UCCA) measurements from volumetric brain 3D T1 -weighted scans related to gradient nonlinearity (GNL) and subject positioning; (ii) the effect of vendor-implemented GNL corrections; and (iii) easily applicable methods that can be used to retrospectively correct data. METHODS: A multiple sclerosis patient was scanned at seven sites using 3T MRI scanners with the same 3D T1 -weighted protocol without GNL-distortion correction...
June 15, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28617993/rigid-body-motion-correction-of-the-liver-in-image-reconstruction-for-golden-angle-stack-of-stars-dce-mri
#15
Adam Johansson, James Balter, Yue Cao
PURPOSE: Respiratory motion can affect pharmacokinetic perfusion parameters quantified from liver dynamic contrast-enhanced MRI. Image registration can be used to align dynamic images after reconstruction. However, intra-image motion blur remains after alignment and can alter the shape of contrast-agent uptake curves. We introduce a method to correct for inter- and intra-image motion during image reconstruction. METHODS: Sixteen liver dynamic contrast-enhanced MRI examinations of nine subjects were performed using a golden-angle stack-of-stars sequence...
June 15, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28616042/cerebral-mechanism-of-puncturing-at-he-mu-point-combination-for-functional-dyspepsia-study-protocol-for-a-randomized-controlled-parallel-trial
#16
Shuai Yin, Yuan Chen, Du Lei, Rui-Rui Sun, Ting-Ting Ma, Pei-Min Feng, Zhao-Xuan He, Xue-Ling Suo, Pei-Hong Ma, Yu-Zhu Qu, Ke Qiu, Miao-Miao Jing, Qi-Yong Gong, Fan-Rong Liang, Jiao Chen, Fang Zeng
Acupuncture is widely used to treat functional dyspepsia with satisfactory outcomes. Combination of the He and Mu acupoints is commonly used and has a synergistic effect on functional dyspepsia; however, its underlying mechanisms remain unclear. Therefore, a randomized controlled parallel clinical trial is currently underway at Chengdu University of Traditional Chinese Medicine, China. This trial is designed to explore the efficacy of and central responses to the He-Mu point combination in patients with functional dyspepsia using functional magnetic resonance imaging...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28615794/deepinfer-open-source-deep-learning-deployment-toolkit-for-image-guided-therapy
#17
Alireza Mehrtash, Mehran Pesteie, Jorden Hetherington, Peter A Behringer, Tina Kapur, William M Wells, Robert Rohling, Andriy Fedorov, Purang Abolmaesumi
Deep learning models have outperformed some of the previous state-of-the-art approaches in medical image analysis. Instead of using hand-engineered features, deep models attempt to automatically extract hierarchical representations at multiple levels of abstraction from the data. Therefore, deep models are usually considered to be more flexible and robust solutions for image analysis problems compared to conventional computer vision models. They have demonstrated significant improvements in computer-aided diagnosis and automatic medical image analysis applied to such tasks as image segmentation, classification and registration...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28615277/alterations-in-the-brain-s-connectome-during-recovery-from-severe-traumatic-brain-injury-protocol-for-a-longitudinal-prospective-study
#18
Virginia Conde, Sara Hesby Andreasen, Tue Hvass Petersen, Karen Busted Larsen, Karine Madsen, Kasper Winther Andersen, Irina Akopian, Kristoffer Hougaard Madsen, Christian Pilebæk Hansen, Ingrid Poulsen, Lars Peter Kammersgaard, Hartwig Roman Siebner
INTRODUCTION: Traumatic brain injury (TBI) is considered one of the most pervasive causes of disability in people under the age of 45. TBI often results in disorders of consciousness, and clinical assessment of the state of consciousness in these patients is challenging due to the lack of behavioural responsiveness. Functional neuroimaging offers a means to assess these patients without the need for behavioural signs, indicating that brain connectivity plays a major role in consciousness emergence and maintenance...
June 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28614824/compact-intraoperative-mri-stereotactic-accuracy-and-future-directions
#19
Daniel Markowitz, Dishen Lin, Sussan Salas, Nina Kohn, Michael Schulder
BACKGROUND: Intraoperative imaging must supply data that can be used for accurate stereotactic navigation. This information should be at least as accurate as that acquired from diagnostic imagers. OBJECTIVES: The aim of this study was to compare the stereotactic accuracy of an updated compact intraoperative MRI (iMRI) device based on a 0.15-T magnet to standard surgical navigation on a 1.5-T diagnostic scan MRI and to navigation with an earlier model of the same system...
June 15, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28613391/evaluation-of-five-diffeomorphic-image-registration-algorithms-for-mouse-brain-magnetic-resonance-microscopy
#20
Zhenrong Fu, Lan Lin, Miao Tian, Jingxuan Wang, Baiwen Zhang, Pingping Chu, Shaowu Li, Muhammad Mohsin Pathan, Yulin Deng, Shuicai Wu
The development of genetically engineered mouse models for neuronal diseases and behavioural disorders have generated a growing need for small animal imaging. High-resolution magnetic resonance microscopy (MRM) provides powerful capabilities for noninvasive studies of mouse brains, while avoiding some limits associated with the histological procedures. Quantitative comparison of structural images is a critical step in brain imaging analysis, which highly relies on the performance of image registration techniques...
June 14, 2017: Journal of Microscopy
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