keyword
https://read.qxmd.com/read/38505220/individual-trabecula-segmentation-validation-in-first-and-second-generation-high-resolution-peripheral-computed-tomography-compared-to-micro-computed-tomography-in-the-distal-radius-and-tibia
#21
JOURNAL ARTICLE
Andreea Teodora Dinescu, Bin Zhou, Yizhong Jenny Hu, Sanchita Agarwal, Elizabeth Shane, Xiang-Dong Edward Guo
High-resolution peripheral quantitative computed tomography (HR-pQCT) has been used for in vivo 3D visualization of trabecular microstructure. Second-generation HR-pQCT (HR-pQCT II) has been shown to have good agreement with first generation HR-pQCT (HR-pQCT I). Advanced Individual Trabecula Segmentation (ITS) decomposes the trabecula network into individual plates and rods. ITS based on HR-pQCT I showed a strong correlation to ITS based on micro-computed tomography (μCT) and identified trabecular changes in metabolic bone diseases...
February 2024: JBMR Plus
https://read.qxmd.com/read/38501225/bbr-affects-macrophage-polarization-via-inhibition-of-nf-%C3%AE%C2%BAb-pathway-to-protect-against-t2dm-associated-periodontitis
#22
JOURNAL ARTICLE
Siying Xia, Rui Jing, Mingyan Shi, Yanan Yang, Meiting Feng, Li Deng, Lijun Luo
BACKGROUND AND OBJECTIVE: Periodontitis is intimately associated with the development of various systemic diseases, among which type 2 diabetes mellitus (T2DM) has a bidirectional relationship with the pathogenesis of periodontitis. The objective of the present work was to investigate the role of berberine (BBR) in periodontitis with T2DM and related mechanisms. METHODS: The mRNA expression of macrophage polarization-related factors in the microenvironment of periodontal inflammation was detected using real-time quantitative PCR (RT-qPCR)...
March 19, 2024: Journal of Periodontal Research
https://read.qxmd.com/read/38500176/three-dimensional-molar-enamel-thickness-and-distribution-patterns-in-late-miocene-lufengpithecus-lufengensis-from-shihuiba-southwest-china
#23
JOURNAL ARTICLE
Lizhao Zhang, Baopu Du, Rong Hu, Lingxia Zhao
Enamel thickness and distribution provide dietary insights in hominoids. Yet, three-dimensional (3D) enamel analysis of the Late Miocene Lufengpithecus from southwest China is lacking. We digitally reconstructed 68 unworn or lightly worn Lufengpithecus (L.) lufengensis molars using micro-computed tomography (micro-CT). Comparisons with modern humans, Homo erectus, extant/fossil Pongo, Pan, and Gorilla reveal L. lufengensis has "intermediate/thick" enamel, thicker than Pongo and Gorilla, but thinner than modern humans and H...
March 18, 2024: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://read.qxmd.com/read/38499876/effect-of-injectable-acellular-adipose-matrix-on-soft-tissue-reconstruction-in-a-murine-model
#24
JOURNAL ARTICLE
Jaewoo Kim, Vinh Vuong The Tran, Ki Yong Hong, Hak Chang
BACKGROUND: The extracellular matrix isolated from adipose tissue, known as acellular adipose matrix (AAM), represents a novel biomaterial. AAM functions as a scaffold that not only supports stem cell proliferation and differentiation but also induces adipogenesis and angiogenesis. This study aims to investigate the volumetric effects and microenvironmental changes associated with injectable AAM in comparison to conventional fat grafting. METHODS: AAM was manufactured from fresh human abdominoplasty fat using a mechanically modified method and then transformed into an injectable form...
March 18, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38496032/enhanced-osteochondral-regeneration-with-a-3d-printed-biomimetic-scaffold-featuring-a-calcified-interfacial-layer
#25
JOURNAL ARTICLE
Di Wu, Kaiwen Zheng, Wenjing Yin, Bin Hu, Mingzhao Yu, Qingxiao Yu, Xiaojuan Wei, Jue Deng, Changqing Zhang
The integrative regeneration of both articular cartilage and subchondral bone remains an unmet clinical need due to the difficulties of mimicking spatial complexity in native osteochondral tissues for artificial implants. Layer-by-layer fabrication strategies, such as 3D printing, have emerged as a promising technology replicating the stratified zonal architecture and varying microstructures and mechanical properties. However, the dynamic and circulating physiological environments, such as mass transportation or cell migration, usually distort the pre-confined biological properties in the layered implants, leading to undistinguished spatial variations and subsequently inefficient regenerations...
June 2024: Bioactive Materials
https://read.qxmd.com/read/38493831/morphology-of-the-physiological-foramen-ii-maxillary-and-mandibular-premolars
#26
JOURNAL ARTICLE
Thomas Gerhard Wolf, Andrea Lisa Waber, Benjamín Briseño Marroquín
INTRODUCTION: Information concerning the anatomy of the physiological foramen is still limited. The aim of this study was to investigate the distance between the physiological and anatomical apex, the shape and diameter of the physiological foramen in maxillary (Mx) and mandibular premolars (Mn). METHODS: The anatomy of the apex of 229 maxillary (first: MxP1; second: MxP2) and 221 mandibular premolars (first: MnP1; second: MnP2) from a mixed Swiss-German population was investigated by means of micro-computed tomography and 3D software-imaging...
March 15, 2024: Journal of Endodontics
https://read.qxmd.com/read/38493123/assessment-of-the-root-and-canal-morphology-in-the-permanent-dentition-of-saudi-arabian-population-using-cone-beam-computed-and-micro-computed-tomography-a-systematic-review
#27
JOURNAL ARTICLE
Mohammed Mustafa, Rumesa Batul, Mohmed Isaqali Karobari, Hadi Mohammed Alamri, Abdulaziz Abdulwahed, Ahmed A Almokhatieb, Qamar Hashem, Abdullah Alsakaker, Mohammad Khursheed Alam, Hany Mohamed Aly Ahmed
INTRODUCTION: Root canal treatment procedures require a thorough understanding of root and canal anatomy. The purpose of this systematic review was to examine the morphological differences of teeth root and their canals assessed using cone-beam computed and micro-computed tomography in Saudi Arabian population. METHODOLOGY: An electronic search was conducted in PubMed / Medline, Scopus, Google Scholar, and Web of Science databases until January 2023 to retrieve related studies...
March 16, 2024: BMC Oral Health
https://read.qxmd.com/read/38492908/mechanoregulation-analysis-of-bone-formation-in-tissue-engineered-constructs-requires-a-volumetric-method-using-time-lapsed-micro-computed-tomography
#28
JOURNAL ARTICLE
Julia K Griesbach, Friederike A Schulte, Gian Nutal Schädli, Marina Rubert, Ralph Müller
Bone can adapt its microstructure to mechanical loads through mechanoregulation of the (re)modeling process. This process has been investigated in vivo using time-lapsed micro-computed tomography (micro-CT) and micro-finite element (FE) analysis using surface-based methods, which are highly influenced by surface curvature. Consequently, when trying to investigate mechanoregulation in tissue engineered bone constructs, their concave surfaces make the detection of mechanoregulation impossible when using surface-based methods...
March 14, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38492037/conservative-management-by-embolization-of-a-ruptured-renal-arterio-venous-malformation-avm-in-hereditary-hemorrhagic-telangiectasia-hht
#29
JOURNAL ARTICLE
Romain L'Huillier, Gaële Pagnoux, Sophie Dupuis-Girod, Nicolas Stacoffe
BACKGROUND: Renal arteriovenous malformation (AVM) in Hereditary Hemorrhagic Telangiectasia (HHT) is uncommon and only few cases have been described, mainly with surgical management because of uncontrolled hematuria. CASE PRESENTATION: We managed a 70-year-old patient with HHT who presented with hematuria and left flank pain. Computed Tomography and ultrasound showed left renal AVM of 18 mm with clotting in the urinary tract. An external ureteral catheter was placed during 3 days to allow rinsing and facilitate elimination of clots...
March 16, 2024: CVIR Endovascular
https://read.qxmd.com/read/38490929/is-the-assessment-of-the-mandibular-molar-danger-zone-affected-by-field-of-view-and-voxel-size-in-cone-beam-computed-tomography-examinations
#30
JOURNAL ARTICLE
Daniella Ribeiro Ferrari, Tânia Maria Soares Reis, Rafael Binato Junqueira, Kivanç Kamburoğlu, Özlem Küçük, Francielle Silvestre Verner
OBJECTIVE: To verify if assessment of the danger zone (DZ) in the mesial root of mandibular molars is affected by field of view (FOV) and voxel sizes in cone beam computed tomography (CBCT) scans. STUDY DESIGN: Forty mandibular molars were scanned by micro-computed tomography, creating the reference standard. The teeth were then submitted for CBCT scans with FOVs of 10 × 5.5 cm and 5 × 5.5 cm and voxel sizes of 0.4, 0.2, 0.15, and 0.075 mm3 . The smallest dentin thickness in the DZ from the mesiobuccal and mesiolingual canals was measured at 2, 4, and 6 mm apical to the root furcation...
February 17, 2024: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://read.qxmd.com/read/38489080/three-dimensional-wall-thickness-distributions-of-unruptured-intracranial-aneurysms-characterized-by-micro-computed-tomography
#31
JOURNAL ARTICLE
Yasutaka Tobe, Takanobu Yagi, Koichi Kawamura, Kenta Suto, Yoichi Sawada, Yoshifumi Hayashi, Hirotaka Yoshida, Kazutoshi Nishitani, Yoshifumi Okada, Shigemi Kitahara, Mitsuo Umezu
Aneurysmal rupture is associated with wall thinning, but the mechanism is poorly understood. This study aimed to characterize the three-dimensional wall-thickness distributions of unruptured intracranial aneurysms. Five aneurysmal tissues were investigated using micro-computed tomography. First, the wall thickness was related to the aneurysmal wall appearances during surgery. The median wall thicknesses of the translucent and non-translucent walls were 50.56 and 155.93 µm, respectively (p < 0...
March 15, 2024: Biomechanics and Modeling in Mechanobiology
https://read.qxmd.com/read/38488753/leukemia-inhibitory-factor-protects-against-experimental-periodontitis-through-immuno-modulations-of-both-macrophages-and-periodontal-ligament-fibroblasts
#32
JOURNAL ARTICLE
Yanjing Ou, Le Fan, Xiaoqi Wang, Haibin Xia, Mengwen Cheng, Jing Huang, Youde Liang, Yining Wang, Yi Zhou
BACKGROUND: To explore the role of leukemia inhibitory factor (LIF) in periodontitis via in vivo and in vitro experiments. METHODS: The second upper molar of LIF knockout mice and their wild-type littermates were ligated for 8 days. Micro-computed tomography (micro-CT), histological analysis, and quantitative real-time polymerase chain reaction (qRT-PCR) were performed. The expression levels of proinflammatory cytokines were examined in mouse bone marrow derived macrophages and human periodontal ligament fibroblasts (HPDLFs) after lipopolysaccharide (LPS) treatment...
March 15, 2024: Journal of Periodontology
https://read.qxmd.com/read/38482805/locally-directed-recombinant-adeno-associated-virus-mediated-igf-1-gene-therapy-enhances-osteochondral-repair-and-counteracts-early-osteoarthritis-in-vivo
#33
JOURNAL ARTICLE
Carolin Peifer, Tamás Oláh, Jagadeesh K Venkatesan, Lars Goebel, Patrick Orth, Gertrud Schmitt, David Zurakowski, Michael D Menger, Matthias W Laschke, Magali Cucchiarini, Henning Madry
BACKGROUND: Restoration of osteochondral defects is critical, because osteoarthritis (OA) can arise. HYPOTHESIS: Overexpression of insulin-like growth factor 1 (IGF-1) via recombinant adeno-associated viral (rAAV) vectors (rAAV-IGF-1) would improve osteochondral repair and reduce parameters of early perifocal OA in sheep after 6 months in vivo. STUDY DESIGN: Controlled laboratory study. METHODS: Osteochondral defects were created in the femoral trochlea of adult sheep and treated with rAAV-IGF-1 or rAAV- lacZ (control) (24 defects in 6 knees per group)...
March 14, 2024: American Journal of Sports Medicine
https://read.qxmd.com/read/38482055/feasibility-study-on-the-introduction-of-micro-ct-technology-for-the-identification-of-radix-bupleuri-and-its-adulterants
#34
JOURNAL ARTICLE
Kehong Chen, Gong Chen, Zhelong Zhuang, Shouhua Luo, Jiaming Liu, Guorong Liu
Background: Radix Bupleuri , a kind of Chinese herbal medicine with great clinical use, is often confused with its adulterants, and it is difficult to identify it without certain knowledge. The existing identification methods have their own drawbacks, so a new method is needed to realize the identification of Radix Bupleuri and its adulterants. Methods: We used Micro Computed Tomography (Micro-CT) to perform tomography scans on Radix Bupleuri and its adulterants, performed data screening and data correction on the obtained DICOM images, and then applied 3D reconstruction, data augmentation, and ResNext deep learning model for the classification study...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38481117/assessment-of-subchondral-bone-microdamage-quantification-using-contrast-enhanced-imaging-techniques
#35
JOURNAL ARTICLE
Babatunde A Ayodele, Fatemeh Malekipour, Charles N Pagel, Eleanor J Mackie, R Chris Whitton
Bone microdamage is common at subchondral bone (SCB) sites subjected to repeated high rate and magnitude of loading in the limbs of athletic animals and humans. Microdamage can affect the biomechanical behaviour of bone under physiological loading conditions. To understand the effects of microdamage on the mechanical properties of SCB, it is important to be able to quantify it. The extent of SCB microdamage had been previously estimated qualitatively using plain microcomputed tomography (μCT) and a radiocontrast quantification method has been used for trabecular bone but this method may not be directly applicable to SCB due to differences in bone structure...
March 13, 2024: Journal of Anatomy
https://read.qxmd.com/read/38478234/combination-of-adipose-derived-stromal-stem-cells-and-decellularized-adipose-tissue-hydrogel-for-osteogenic-applications
#36
JOURNAL ARTICLE
Kainat Ahmed, Haadia Tauseef, Omair A Mohiuddin
Adipose-derived stromal/stem cells (ASCs) and decellularized adipose tissue (DAT) are adipose tissue products obtained from individuals undergoing fat removal procedures like liposuction, lipectomy, or breast reduction. DAT hydrogel is prepared by removing the cells from the adipose tissue and digesting it to form a liquid material that forms a gel at physiological temperature. ASCs seeded on DAT have displayed osteogenic potential in vitro and in animal models of bone defects. Herein, we describe the methods for preparing DAT hydrogel, ASC seeding in DAT hydrogel, osteogenic differentiation of ASCs, creation of critical-sized femur defect model in mice, its treatment with ASC-DAT hydrogel, and analyses...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38477745/bone-remodeling-and-responsiveness-to-mechanical-stimuli-in-individuals-with-type-1-diabetes-mellitus
#37
JOURNAL ARTICLE
Matthias Walle, Ankita Duseja, Danielle E Whittier, Tatiane Vilaca, Margaret Paggiosi, Richard Eastell, Ralph Müller, Caitlyn J Collins
Type 1 diabetes mellitus (T1DM) has been linked to increased osteocyte apoptosis, local accumulation of mineralized lacunar spaces, and microdamage suggesting an impairment of the mechanoregulation network in affected individuals. Diabetic neuropathy might exacerbate this dysfunction through direct effects on bone turnover, and indirect effects on balance, muscle strength, and gait. However, the in vivo effects of impaired bone mechanoregulation on bone remodeling in humans remain underexplored. This longitudinal cohort study assessed consenting participants with T1DM and varying degree of distal symmetric sensorimotor polyneuropathy (T1DM, n = 20, median age 46...
January 4, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38477742/approaching-virtual-osteoid-volume-estimation-and-in-depth-tissue-characterization-in-patients-with-tumor-induced-osteomalacia
#38
JOURNAL ARTICLE
Felix N Schmidt, Julian Delsmann, Bashar Yazigi, Frank Timo Beil, Michael Amling, Ralf Oheim
INTRODUCTION: Tumor-induced osteomalacia (TIO) poses a significant diagnostic challenge, leading to increased disease duration and patient burden also by missing clinical suspicion. Today, diagnosis of osteomalacia relies on invasive iliac crest biopsy, if needed. Therefore, a noninvasive, method would be beneficial for patients with severe osteomalacia, such as TIO, and inform their clinical management to address specific needs, like estimating the regeneration capacity at high osteoid-volumes or the potential of a hungry bone syndrome after tumor-removal...
January 13, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38476716/evaluation-of-apical-transportation-and-centering-ability-of-three-single-file-systems-in-severely-curved-canals-using-micro-computed-tomography
#39
JOURNAL ARTICLE
Seyed Mohsen Hasheminia, Samaneh Soltani, Fateme Mohamadian, Masoud Saatchi, Seyed Mohsen Sadeghi
BACKGROUND: This study aimed to compare the apical transportation and centering ability of One Curve, HyFlex EDM, and EdgeFile X1 in curved mesiobuccal and mesiolingual canals of mandibular first molars. MATERIALS AND METHODS: In this in vitro experimental study, 60 mesiobuccal and mesiolingual canals of the mandibular first molars with a minimum length of 19 mm and 25°-40° curvature were randomly divided into three groups ( n = 20) for root canal preparation with One Curve, HyFlex EDM, and EdgeFile X1...
2024: Dental Research Journal
https://read.qxmd.com/read/38475954/formation-of-dentinal-microcracks-after-root-canal-preparation-with-four-kinds-of-mechanical-nickel-titanium-files
#40
JOURNAL ARTICLE
Zi Wang, Ming Xue
OBJECTIVES: This study aimed to compare the differences among four kinds of mechanical Ni-Ti files including T-Flex, Reciproc Blue (RB), ProTaper Gold (PTG), and ProTaper Universal (PTU) in dentinal microcrack generation after root canal preparation in vitro by using micro-computed tomography (micro-CT) analysis. METHODS: A total of 32 freshly extracted double-root-canal premolars with an angle not exceeding 10° were selected and established as root canal preparation models in vitro ...
February 1, 2024: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
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