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https://www.readbyqxmd.com/read/29453145/demographic-and-clinical-characteristics-associated-with-a-history-of-bizarre-delusions-in-a-cross-diagnostic-sample-of-individuals-with-psychotic-disorders
#1
Cagri Yuksel, Seheryeli Yilmaz, Ariana Nesbit, Gresa Carkaxhiu, Caitlin Ravichandran, Paola Salvatore, Samira Pingali, Bruce Cohen, Dost Ongur
Bizarre delusions (BizD) are not specific to schizophrenia (SZ) and can be found in other psychotic disorders. However, to date, there are no studies investigating socio-demographic and clinical characteristics associated with BizD across the psychosis spectrum. In this study 819 subjects with a diagnosis of SZ (n = 250), schizoaffective disorder (SZA) (n = 228) and bipolar I disorder (BD) (n = 341) were included. Patients with history of BizD and with no BizD were compared with respect to socidemographic and clinical variables, and predictors of BizD were explored...
February 9, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29448305/development-and-validation-of-gc-ms-ms-method-for-simultaneous-quantitation-of-several-antipsychotics-in-human-plasma-and-oral-fluid
#2
Tiago Rosado, David Oppolzer, Belinda Cruz, Mário Barroso, Samira Varela, Victor Oliveira, Carlos Leitão, Eugenia Gallardo
RATIONALE: Antipsychotic drugs are prescription medications used to treat psychotic disorders, such as schizophrenia, schizoaffective disorder, or psychotic depression. With several antipsychotic drugs currently available all over the world, this class of drugs has quickly gotten importance in both clinical and forensic context. This work describes the development and validation of a methodology for the determination of seven antipsychotic drugs in plasma and oral fluid samples. METHODS: The antipsychotic drugs (chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, cyamemazine and, levomepromazine) were isolated from 0...
February 15, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29432502/comparison-of-the-effect-of-intravenous-anesthetics-used-for-anesthesia-during-electroconvulsive-therapy-on-the-hemodynamic-safety-and-the-course-of-ect
#3
REVIEW
Rafał Wojdacz, Łukasz Święcicki, Anna Antosik-Wójcińska
Electroconvulsive therapy (ECT) is the treatment method widely used in psychiatric disorders such as depression, bipolar disorder, schizophrenia and schizoaffective disorder. The advantage of ECT is therapeutic response that occurs significantly earlier than during pharmacotherapy. Initially ECTwas used without anesthesia. Then, in the 1950s procedures with general anesthesia were introduced to reduce the complications that may occur during a seizure caused by ECT, such as broken bones, teeth, tendon rupture, muscle damage...
December 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29428116/clinical-and-demographic-variables-associated-coping-and-the-burden-of-caregivers-of-schizophrenia-patients
#4
Belvy Mora-Castañeda, María Márquez-González, Alberto Fernández-Liria, Ricardo de la Espriella, Néstor Torres, Álvaro Arenas Borrero
OBJECTIVE: To analyse of the relationship between burden of illness and coping strategies and the demographic variables of caregivers, and the demographic and clinical variables of people diagnosed with schizophrenia. METHODS: Multicentre correlational cross-sectional study including 70 people diagnosed with schizophrenia, or a schizoaffective disorder, and 70 primary informal caregivers. They were evaluated using Zarit Caregiver Burden Inventory, Family Coping Strategies Questionnaire, Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, and the brief Disability Assessment Scale...
January 2018: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/29427912/adjunctive-therapy-with-statins-in-schizophrenia-patients-a-meta-analysis-and-implications
#5
Hong Shen, Rui Li, Rong Yan, Xia Zhou, Xia Feng, Mengjie Zhao, Hong Xiao
There are some conflicting results regarding the benefit of adjunctive therapy with statins for severity of negative symptoms in schizophrenia. This study aimed to verify whether statins use for adjunctive therapy was indeed beneficial to improve psychiatric symptoms in schizophrenia. The data were from CENTRAL, PubMed, Embase and MEDLINE. The Boolean search term used for the electronic database search was (statin OR simvastatin OR atorvastatin OR fluvastatin OR lovastatin OR mevastatin OR pitavastatin OR pravastatin OR rosuvastatin OR cerivastatin) and (schizophrenia OR schizoaffective disorder OR psychosis)...
February 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29422299/a-randomized-controlled-trial-examining-a-cognitive-behavioral-therapy-intervention-enhanced-with-cognitive-remediation-to-improve-work-and-neurocognition-outcomes-among-persons-with-schizophrenia-spectrum-disorders
#6
Marina Kukla, Morris D Bell, Paul H Lysaker
This single blind, three-armed randomized controlled trial compared cognitive behavioral therapy (CBT) enhanced with cognitive remediation (CBT+CR) to CBT alone and an active control condition on work and neurocognition outcomes for persons with schizophrenia spectrum disorders. Seventy-five adult outpatients with schizophrenia or schizoaffective disorder were randomized to three study conditions (N=25 per group). The CBT intervention was the Indianapolis Vocational Intervention program (IVIP), consisting of weekly group and individual sessions focused on work-related content...
February 5, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29421173/effects-of-chlorpromazine-on-sleep-quality-clinical-and-emotional-measures-among-patients-with-schizophrenia
#7
Qingli Meng, Rongqin Li, Feng Hou, Qiulan Zhang
OBJECTIVES: The present study was aimed to examine the effects of chlorpromazine on sleep quality, clinical and emotional measures in people suffering from schizophrenia. PATIENTS AND METHODS: Twenty-five patients with schizophrenia or schizoaffective disorder were enrolled in this study. Our study included a one-week running-in no-treatment period and two-month experimental period. Patients received chlorpromazine during the experimental period. The baseline and treatment outcome were recorded...
February 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29420822/bifactor-modeling-of-the-positive-and-negative-syndrome-scale-generalized-psychosis-spans-schizoaffective-bipolar-and-schizophrenia-diagnoses
#8
Ariana E Anderson, Stephen Marder, Steven P Reise, Adam Savitz, Giacomo Salvadore, Dong Jing Fu, Qingqin Li, Ibrahim Turkoz, Carol Han, Robert M Bilder
Objective: Common genetic variation spans schizophrenia, schizoaffective and bipolar disorders, but historically, these syndromes have been distinguished categorically. A symptom dimension shared across these syndromes, if such a general factor exists, might provide a clearer target for understanding and treating mental illnesses that share core biological bases. Method: We tested the hypothesis that a bifactor model of the Positive and Negative Syndrome Scale (PANSS), containing 1 general factor and 5 specific factors (positive, negative, disorganized, excited, anxiety), explains the cross-diagnostic structure of symptoms better than the traditional 5-factor model, and examined the extent to which a general factor reflects the overall severity of symptoms spanning diagnoses in 5094 total patients with a diagnosis of schizophrenia, schizoaffective, and bipolar disorder...
February 6, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29415689/reasons-for-lithium-discontinuation-in-men-and-women-with-bipolar-disorder-a-retrospective-cohort-study
#9
Louise Öhlund, Michael Ott, Sofia Oja, Malin Bergqvist, Robert Lundqvist, Mikael Sandlund, Ellinor Salander Renberg, Ursula Werneke
BACKGROUND: Lithium remains first choice as maintenance treatment for bipolar affective disorder. Yet, about half of all individuals may stop their treatment at some point, despite lithium's proven benefits concerning the prevention of severe affective episodes and suicide. METHODS: Retrospective cohort study in the Swedish region of Norrbotten into the causes of lithium discontinuation. The study was set up to (1) test whether patients with bipolar affective disorder or schizoaffective disorder, treated with lithium maintenance therapy, were more likely to discontinue lithium because of adverse effects than lack of therapeutic effectiveness, (2) explore gender differences, (3) understand the role of diagnosis and (4) identify who, patient or doctor, took the initiative to stop lithium...
February 7, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29407565/reduced-cardiovascular-fitness-associated-with-exposure-to-clozapine-in-individuals-with-chronic-schizophrenia
#10
David D Kim, Donna J Lang, Ric M Procyshyn, Melissa L Woodward, Kai Kaufman, Randall F White, William G Honer, Darren E R Warburton
Studies show that individuals with schizophrenia have impaired cardiovascular fitness (i.e., low peak aerobic power (VO2peak)). It is speculated that antipsychotics with adverse cardiovascular and metabolic profiles, in particular clozapine, have a significant impact on VO2peak. In this cross-sectional study, we examined whether exposure to clozapine was associated with further reduced VO2peak compared with non-clozapine antipsychotics. Thirty participants with chronic schizophrenia or schizoaffective disorder were divided into clozapine and non-clozapine groups...
January 17, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29405754/developing-dimensional-pandiagnostic-inhibitory-control-constructs-with-self-report-and-neuropsychological-data
#11
Natania A Crane, Alvaro Vergés, Masoud Kamali, Runa Bhaumik, Kelly A Ryan, David F Marshall, Erika F H Saunders, Michelle T Kassel, Anne L Weldon, Melvin G McInnis, Scott A Langenecker
Trait markers, or intermediate phenotypes linking different units of analysis (self-report, performance) from the Research Domain Criteria (RDoC) matrix across populations is a necessary step in identifying at-risk individuals. In the current study, 150 healthy controls (HC) and 456 individuals with bipolar disorder (BD) Type I or II, NOS (not otherwise specified) or Schizoaffective BD completed self-report neuropsychological tests of inhibitory control (IC) and executive functioning. Bifactor analyses were used to examine the factor structure of these measures and to evaluate for invariance across groups...
February 1, 2018: Assessment
https://www.readbyqxmd.com/read/29396860/trapped-like-a-butterfly-in-a-spider-s-web-experiences-of-female-spousal-caregivers-in-the-care-of-husbands-with-severe-mental-illness
#12
Hossein Ebrahimi, Naeimeh Seyedfatemi, Hossein Namdar Areshtanab, Fatemeh Ranjbar, Bill Whitehead, Farnaz Rahman
BACKGROUND: Family involvement in the care of patients with chronic illness is essential to provide a backbone of support for them. However, little is known about how female spousal caregivers are confronted with challenges while taking care of their husbands with severe mental illness. OBJECTIVE: This study aimed to describe the experiences of female spousal caregivers in the care of husbands with severe mental illness. DESIGN: An exploratory qualitative study...
February 3, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29387876/mortality-rates-after-the-first-diagnosis-of-psychotic-disorder-in-adolescents-and-young-adults
#13
Gregory E Simon, Christine Stewart, Bobbi Jo Yarborough, Frances Lynch, Karen J Coleman, Arne Beck, Belinda H Operskalski, Robert B Penfold, Enid M Hunkeler
Importance: Individuals with psychotic disorders have increased mortality, and recent research suggests a marked increase shortly after diagnosis. Objective: To use population-based data to examine overall and cause-specific mortality after first diagnosis of a psychotic disorder. Design, Setting, and Participants: This cohort study used records from 5 integrated health systems that serve more than 8 million members in 5 states. Members aged 16 through 30 years who received a first lifetime diagnosis of a psychotic disorder from September 30, 2009, through September 30, 2015, and 2 comparison groups matched for age, sex, health system, and year of diagnosis were selected from all members making an outpatient visit (general outpatient group) and from all receiving a first diagnosis of unipolar depression (unipolar depression group)...
January 31, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29385961/national-estimates-of-recovery-remission-from-serious-mental-illness
#14
Mark S Salzer, Eugene Brusilovskiy, Greg Townley
OBJECTIVE: A broad range of estimates of recovery among previously institutionalized persons has been reported, but no current, community-based national estimate of recovery from serious mental illness exists. This study reports recovery rate results, based on a remission definition, and explores related demographic factors. METHODS: A national, geographically stratified, and random cross-sectional survey conducted from September 2014 to December 2015 resulted in responses from more than 41,000 individuals...
February 1, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29368813/selective-noradrenaline-reuptake-inhibitors-for-schizophrenia
#15
REVIEW
Paul R L Matthews, Jamie Horder, Michael Pearce
BACKGROUND: Schizophrenia is frequently a chronic and disabling illness with a heterogeneous range of symptoms. The positive symptoms usually respond to antipsychotics but the cognitive and negative symptoms of schizophrenia are difficult to treat with conventional antipsychotics and significantly impact on quality of life and social outcomes. Selective noradrenaline reuptake inhibitors (NRIs) increase prefrontal dopamine and noradrenaline levels without significantly affecting subcortical dopamine levels, making them an attractive candidate for treating cognitive and negative symptoms...
January 25, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29360577/test-retest-reliability-of-the-diagnosis-of-schizoaffective-disorder-in-childhood-and-adolescence-a-systematic-review-and-meta-analysis
#16
Sarah Salamon, Hanno Santelmann, Jeremy Franklin, Christopher Baethge
OBJECTIVES: Reliability of schizoaffective disorder (SAD) diagnoses is low in adults but unclear in children and adolescents (CAD). We estimate the test-retest reliability of SAD and its key differential diagnoses (schizophrenia, bipolar disorder, and unipolar depression). METHODS: Systematic literature search of Medline, Embase, and PsycInfo for studies on test-retest reliability of SAD, in CAD. Cohen's kappa was extracted from studies. We performed meta-analysis for kappa, including subgroup and sensitivity analysis (PROSPERO protocol: CRD42013006713)...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29353769/the-impact-of-self-stigmatization-on-medication-attitude-in-schizophrenia-patients
#17
Tobias Feldhaus, Sebastian Falke, Lara von Gruchalla, Birgit Maisch, Christina Uhlmann, Eva Bock, Rebekka Lencer
Negative attitudes towards medication in schizophrenia patients are one major factor contributing to non-adherence behavior. Besides, self-stigmatization represents another frequent and important obstacle in patients suffering from psychotic disorders. Here, we investigated possible associations between medication adherence attitude and the extent of self-stigmatization, while also exploring factors related to self-stigmatization. Sociodemographic characteristics, clinical variables, medication attitude and self-stigmatization were assessed among 81 subjects with schizophrenia or schizoaffective disorder...
January 9, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29352823/neurocognitive-and-self-efficacy-benefits-of-cognitive-remediation-in-schizophrenia-a-randomized-controlled-trial
#18
Shayden D Bryce, Susan L Rossell, Stuart J Lee, Richard J Lawrence, Eric J Tan, Sean P Carruthers, Jennie L Ponsford
OBJECTIVES: The aim of this study was to evaluate the impact of computer-assisted "drill-and-strategy" cognitive remediation (CR) for community-dwelling individuals with schizophrenia on cognition, everyday self-efficacy, and independent living skills. METHODS: Fifty-six people with schizophrenia or schizoaffective disorder were randomized into CR or computer game (CG) playing (control), and offered twenty 1-hr individual sessions in a group setting over 10 weeks...
January 21, 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29352477/benzodiazepines-for-antipsychotic-induced-tardive-dyskinesia
#19
REVIEW
Hanna Bergman, Paranthaman S Bhoopathi, Karla Soares-Weiser
BACKGROUND: Tardive dyskinesia (TD) is a disfiguring movement disorder, often of the orofacial region, frequently caused by using antipsychotic drugs. A wide range of strategies have been used to help manage TD, and for those who are unable to have their antipsychotic medication stopped or substantially changed, the benzodiazepine group of drugs have been suggested as a useful adjunctive treatment. However, benzodiazepines are very addictive. OBJECTIVES: To determine the effects of benzodiazepines for antipsychotic-induced tardive dyskinesia in people with schizophrenia, schizoaffective disorder, or other chronic mental illnesses...
January 20, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29346672/learning-to-live-with-schizoaffective-disorder-a-transformative-journey-toward-recovery
#20
(no author information available yet)
No abstract text is available yet for this article.
January 13, 2018: Schizophrenia Bulletin
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