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Deanna L Kelly, Megan M Powell, Heidi J Wehring, MacKenzie A Sayer, Ann Marie Kearns, Ann L Hackman, Robert W Buchanan, Rebecca B Nichols, Heather A Adams, Charles M Richardson, Gopal Vyas, Robert P McMahon, Amber K Earl, Kelli M Sullivan, Fang Liu, Sarah E Luttrell, Faith B Dickerson, Stephanie M Feldman, Supriya Narang, Maju M Koola, Peter F Buckley, Jill A RachBeisel, Joseph P McEvoy
PURPOSE/BACKGROUND: Prolactin-related adverse effects contribute to nonadherence and adverse health consequences, particularly in women with severe mental illness. Treating these adverse effects may improve treatment acceptability, adherence, and long-term outcomes. METHODS/PROCEDURES: Premenopausal women with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder were recruited for a randomized, double-blind, placebo-controlled 16-week trial of adjunct aripiprazole (5-15 mg/d)...
June 15, 2018: Journal of Clinical Psychopharmacology
Sonia Dollfus, Nemat Jaafari, Olivier Guillin, Benoit Trojak, Marion Plaze, Ghassen Saba, Cécilia Nauczyciel, Aurélie Montagne Larmurier, Nathalie Chastan, Vincent Meille, Marie-Odile Krebs, Samar S Ayache, Jean Pascal Lefaucheur, Annick Razafimandimby, Elise Leroux, Rémy Morello, Jean Marie Batail, Perrine Brazo, Nicolas Lafay, Issa Wassouf, Ghina Harika-Germaneau, Remy Guillevin, Carole Guillevin, Emmanuel Gerardin, Maud Rotharmel, Benoit Crépon, Raphael Gaillard, Christophe Delmas, Gael Fouldrin, Guillaume Laurent, Clément Nathou, Olivier Etard
INTRODUCTION: Despite extensive testing, the efficacy of low-frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) of temporo-parietal targets for the treatment of auditory verbal hallucinations (AVH) in patients with schizophrenia is still controversial, but promising results have been reported with both high-frequency and neuronavigated rTMS. Here, we report a double-blind sham-controlled study to assess the efficacy of high-frequency (20 Hz) rTMS applied over a precise anatomical site in the left temporal region using neuronavigation...
April 6, 2018: Schizophrenia Bulletin
Daniel López-Mongay, Maribel Ahuir, Josep Mª Crosas, J Blas Navarro, José Antonio Monreal, Jordi E Obiols, Diego Palao
The objective of this study was to explore social functioning in schizophrenic patients who have suffered child sexual abuse (CSA) in comparison with those who have not suffered from it in a Spanish sample of 50 patients with schizophrenia or schizoaffective disorder. The Quality of Life (QOL) Scale, the Childhood Trauma Questionnaire (CTQ-SF), and the NEO Five Factor Inventory (NEO-FFI) were administered in this study. We found a CSA prevalence of 22% in our sample. Results showed that QOL global scores reduced by 9...
June 1, 2018: Journal of Interpersonal Violence
Ana Claudia Becattini-Oliveira, Douglas de Farias Dutra, Bárbara Spenciere de Oliveira Campos, Verônica Carvalho de Araujo, Helenice Charchat-Fichman
Performance based assessment instruments have been employed in functional capacity measurement of mental disorders. The aim of this systematic review was to identify the psychometric properties of the UCSD Performance-based Skill Assessment (UPSA). A search was conducted using the PRISMA protocol and 'UPSA' as key word term on electronic databases, with a date range for articles published from 2001-2017. Published studies involving community-dwelling adults were included. Pharmacological and/or clinical interventions involving clinical outcomes and/or institutionalized samples were excluded...
May 18, 2018: Psychiatry Research
Aislinn J Williams, Zongshan Lai, Seth Knight, Masoud Kamali, Shervin Assari, Melvin G McInnis
OBJECTIVE: Despite their widespread use in bipolar disorder, there is controversy surrounding the inclusion of antidepressant medications in the disorder's management. We sought to identify which demographic, socioeconomic, and clinical factors are associated with antidepressant exposure in bipolar disorder and which bipolar disorder patients are most likely to report a history of antidepressant-induced mania (AIM) when exposed to antidepressants. METHODS: Our study included subjects with bipolar I disorder (n = 309), bipolar II disorder (n = 66), and bipolar disorder not otherwise specified (n = 27) and schizoaffective disorder, bipolar type (n = 14), from a longitudinal, community-based study...
May 15, 2018: Journal of Clinical Psychiatry
Paulina Riess, Luisa Gonzalez, Panagiota Korenis
Federal law makes it a crime to threaten the President of the United States. The Secret Service conducts thousands of violence risk assessments each year. Literature suggests that 75% of individuals who make threats have been diagnosed with a mental illness (1). Studies show that prominent symptoms in presidential assassins include persecutory and grandiose delusions, hence falling into the category of psychotic disorders. We present a case of a patient diagnosed with Schizoaffective Disorder brought to CPEP (Comprehensive Psychiatric Emergency Program) by the Secret Service for repeatedly dialing 911 and making threats to the President...
2018: Frontiers in Psychiatry
Joep H Schoemaker, Ad J J M Vingerhoets, Robin A Emsley
IntroductionDespite consistently high discontinuation rates due to withdrawal of consent (WOC) and insufficient therapeutic effect (ITE) in schizophrenia trials, insight into the underlying factors contributing to poor satisfaction with treatment and dropout is limited. A better understanding of these factors could help to improve trial design and completion rates. METHODS: Using data from 1,136 trial participants with schizophrenia or schizoaffective disorder, we explored associations between predictor variables with (1) dropout due to WOC and ITE and (2) satisfaction with treatment among patients and investigators by means of hierarchic multiple regression analyses...
June 5, 2018: CNS Spectrums
Alma Mihaljević-Peleš, Maja Bajs Janović, Ana Stručić, Marina Šagud, Milena Skočić HanŽek, Maja Živković, Špiro Janović
Despite controversy, ECT has been recognized as significantly effective for the treatment of mental disorders since 1938, when Cerletti and Bini introduced ECT in clinical psychiatric practice for treatment of schizophrenia. In the next period, indication for ECT switched more toward depression and catatonia. ECT was even banned from psychiatric training in 1960's, due to the anti-psychiatric movement, which were fortified by Oscar winning movie "One Flew over the Cuckoo's Nest". Due to its robust effectiveness, ECT revived in the early 1980's and today holds its position in clinical psychiatric practices around the world...
June 2018: Psychiatria Danubina
Miika Nietola, Anni Heiskala, Tanja Nordström, Jouko Miettunen, Jyrki Korkeila, Erika Jääskeläinen
BACKGROUND: Psychotic depression (PD) is heavily understudied despite high mortality and the severe course of illness. A majority of the studies conducted so far are also largely based on selected clinical samples. The aim of this study was to examine the clinical characteristics of PD in a representative prospective birth cohort sample. METHODS: The Northern Finland Birth Cohort 1966 is a well-known prospective population-based cohort including 12 058 people followed since mid-pregnancy...
May 30, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
Chih-Ken Chen, Chun-Yi Lee, Yu Lee, Chi-Fa Hung, Yu-Chi Huang, Sheng-Yu Lee, Ming-Chyi Huang, Mian-Yoon Chong, Yi-Chih Chen, Liang-Jen Wang
This study seeks to determine whether the cognition profiles of patients with schizoaffective disorder (SAD), schizophrenia and bipolar I disorder (BD) are distinguishable. A total of 227 participants, comprising 88 healthy control subjects, 50 patients with SAD, 48 patients with schizophrenia and 41 patients with BD, were recruited. The participants' cognitive functions were evaluated using the Brief Assessment of Cognition in Schizophrenia (BACS). A discriminant functions analysis (DFA) was conducted to determine whether using cognitive performance can be used to distinguish these participant groups...
May 24, 2018: Psychiatry Research
Hannah E Brown, Kamber L Hart, Leslie A Snapper, Joshua L Roffman, Roy H Perlis
A measure of planning and impulse control, the delay-discounting (DD) task estimates the extent to which an individual decreases the perceived value of a reward as the reward is delayed. We examined cross-disorder performance between healthy controls (n = 88), individuals with bipolar disorder (n = 23), major depressive disorder (n = 43), and primary psychotic disorders (schizophrenia and schizoaffective disorder; n = 51) on the DD task (using a $10 delayed larger reward), as well as the interaction of DD scores with other symptom domains (cognition, psychosis, and affect)...
May 28, 2018: NPJ Schizophrenia
Tian-Hang Zhou, Nora E Mueller, Kevin M Spencer, Sonal G Mallya, Kathryn Eve Lewandowski, Lesley A Norris, Deborah L Levy, Bruce M Cohen, Dost Öngür, Mei-Hua Hall
OBJECTIVES: Gamma oscillation is important for cortico-cortical coordination and the integration of information across neural networks. The 40 Hz auditory steady-state response (ASSR), which reflects neural synchrony in the gamma band (30-100 Hz), is abnormal in patients with schizophrenia (SZ). The present study used the ASSR at multiple frequencies to examine (1) gamma dysfunction in patients with SZ, schizoaffective (SA), and bipolar disorder (BD) compared with controls, (2) the relationship between ASSR measures and clinical symptom severity, and (3) the relationship between ASSR measures and real-life community functioning...
May 25, 2018: Schizophrenia Research
Kristina Melkersson, Sophie Bensing
OBJECTIVES: Evidence has accumulated that an inflammatory, possibly autoimmune-mediated, process in the central nervous system (CNS), and by way of an aberrant immune system, may underlie the development of schizophrenia. Therefore, the aim of this study was to evaluate patients with schizophrenia or related psychosis for blood-brain barrier (BBB) function and immunoglobulin (Ig)G synthesis within the CNS. METHODS: Fifteen patients with schizophrenia or schizoaffective disorder and 12 controls were investigated using lumbar puncture and blood sampling...
March 27, 2018: Neuro Endocrinology Letters
Maria Tavakoli-Ardakani, Hamide Abbaspour, Abdollah Farhadi Nasab, Azadeh Mazaheri Meibodi, Ali Kheradmand
Memantine, an uncompetitive antagonist of glutamate receptor of the N-methyl-D-aspartate type is approved for the treatment of moderate to severe Alzheimer disease (1). A growing body of evidence supports a link between the glutamatergic neurotransmission and schizophrenia (2). The aim of this study was to examine the efficacy and safety of memantine as an adjunctive treatment for antipsychotics in patient with psychopathology of schizophrenia and schizoaffective. In this study, we assessed the effect of memantine on the pro-inflammatory cytokines such as IL6, TNFα and CRP...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Dror Ben-Zeev, Rachel M Brian, Geneva Jonathan, Lisa Razzano, Nicole Pashka, Elizabeth Carpenter-Song, Robert E Drake, Emily A Scherer
OBJECTIVE: mHealth approaches that use mobile phones to deliver interventions can help improve access to care for people with serious mental illness. The goal was to evaluate how mHealth performs against more traditional treatment. METHODS: A three-month randomized controlled trial was conducted of a smartphone-delivered intervention (FOCUS) versus a clinic-based group intervention (Wellness Recovery Action Plan [WRAP]). Participants were 163 clients, mostly from racial minority groups and with long-term, serious mental illness (schizophrenia or schizoaffective disorder, 49%; bipolar disorder, 28%; and major depressive disorder, 23%)...
May 25, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
Igor Yakovenko, Rebecca Fortgang, Jennifer Prentice, Rani A Hoff, Marc N Potenza
Background and aims Published research on the relationship between disordered gambling and schizophrenia is limited. However, existing data suggest that individuals with schizophrenia/schizoaffective disorder may have a high prevalence of co-occurring disordered gambling. As such, effective strategies for screening and assessing gambling-related problems in individuals with psychosis are needed. The goal of this study was to explore the correlates of increased gambling frequency and chasing behavior, a hallmark feature of gambling disorder, in a sample of individuals with schizophrenia and schizoaffective disorders...
May 23, 2018: Journal of Behavioral Addictions
Christopher R Bowie, Michael W Best, Colin Depp, Brent T Mausbach, Thomas L Patterson, Ann E Pulver, Philip D Harvey
OBJECTIVES: Schizophrenia and bipolar disorder overlap considerably. Schizophrenia is a primary psychotic disorder, whereas approximately half of people with bipolar disorder will experience psychosis. In this study, we examined the extent to which cognitive and functional impairments are related to the presence and history of psychosis across the two disorders. METHOD: A total of 633 participants with bipolar disorder I, schizophrenia, and schizoaffective disorder were recruited for a study on the genetics of cognition and functioning in bipolar disorder and schizophrenia...
May 18, 2018: Bipolar Disorders
Tyler B Grove, Beier Yao, Savanna A Mueller, Merranda McLaughlin, Vicki L Ellingrod, Melvin G McInnis, Stephan F Taylor, Patricia J Deldin, Ivy F Tso
Impaired visual integration is well documented in schizophrenia and related to functional outcomes. However, it is unclear if this deficit is specific to schizophrenia, or characteristic of psychosis more broadly. To address this question, this study used a Bayesian model comparison approach to examine the evidence of three grouping models of visual integration performance in 116 individuals with schizophrenia (SZ), schizoaffective disorder (SA), bipolar disorder (BD) with or without a history of prominent psychosis (BDP+ and BDP-, respectively), or no psychiatric diagnosis (healthy controls; HC)...
May 7, 2018: Psychiatry Research
Paolo Girardi, Antonio Del Casale, Chiara Rapinesi, Georgios D Kotzalidis, Francesca Splendori, Claudio Verzura, Giada Trovini, Serena Sorice, Dario Carrus, Iginia Mancinelli, Anna Comparelli, Sergio De Filippis, Antonio Francomano, Andrea Ballerini, Andrea Marcellusi, Francesco S Mennini, Giuseppe Ducci, Gabriele Sani, Maurizio Pompili, Roberto Brugnoli
BACKGROUND: Long-acting injectable (LAI) antipsychotics can improve medication adherence and reduce hospitalisation rates compared with oral treatments. Paliperidone palmitate (PAL) and aripiprazole monohydrate (ARI) LAI treatments were associated with improvements in global functioning in patients with schizophrenia. OBJECTIVE: The objective of this study was to assess the predictive factors of better overall functioning in patients with chronic schizophrenia and schizoaffective disorder treated with PAL and ARI...
May 15, 2018: Human Psychopharmacology
Amanda L Rodrigue, Jennifer E McDowell, Neeraj Tandon, Matcheri S Keshavan, Carol A Tamminga, Godfrey D Pearlson, John A Sweeney, Robert D Gibbons, Brett A Clementz
BACKGROUND: Cognitive and structural brain abnormalities range from mild to severe in psychosis. The relation of specific cognitive functions to specific brain structures across the psychosis spectrum is less certain. METHODS: Participants (n = 678) with bipolar, schizoaffective, or schizophrenia psychoses and healthy control subjects were recruited via the Bipolar-Schizophrenia Network for Intermediate Phenotypes. The Schizo-Bipolar Scale was used to create a psychosis continuum (from purely affective to purely nonaffective)...
March 31, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
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