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https://www.readbyqxmd.com/read/28505669/add-on-antidepressants-in-the-naturalistic-treatment-of-schizophrenia-spectrum-disorder-when-who-and-how
#1
Rebecca Schennach, Michael Obermeier, Florian Seemüller, Markus Jäger, Max Schmauss, Gerd Laux, Herbert Pfeiffer, Dieter Naber, Lutz G Schmidt, Wolfgang Gaebel, Joachim Klosterkötter, Isabella Heuser, Wolfgang Maier, Matthias R Lemke, Eckart Rüther, Stefan Klingberg, Markus Gastpar, Ilja Spellmann, Richard Musil, Hans-Jürgen Möller, Michael Riedel
The aim of this study was to evaluate antidepressant add-on treatment within the acute treatment of schizophrenia spectrum disorder patients. Antidepressant add-on was evaluated in 365 patients within a naturalistic multicenter study. Patients with/without antidepressant add-on were compared regarding clinical and treatment-related variables, response and remission, and remission of depressive and negative symptoms. The efficacy of antidepressant add-on treatment was furthermore analyzed applying marginal structure models...
May 15, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28496495/cortical-alpha-activity-in-schizoaffective-patients
#2
Mahdi Moeini, Ali Khaleghi, Mohammad Reza Mohammadi, Hadi Zarafshan, Rachel L Fazio, Hamid Majidi
Objective: Electrophysiological studies have identified abnormal oscillatory activities in the cerebral cortex in schizophrenia and mood disorders. Biological and pathophysiological evidence suggests specific deficits in serotonin (5-HT) receptor function in schizoaffective disorder (SA), a clinical syndrome with characteristics of both schizophrenia and bipolar disorder. This study investigated alpha oscillations in patients with SA. Method: Electroencephalography was used to measure ongoing and evoked alpha oscillations in 38 adults meeting Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV) criteria for SA, and in 39 healthy controls...
January 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/28492457/the-role-of-amantadine-withdrawal-in-3-cases-of-treatment-refractory-altered-mental-status
#3
Leah D Fryml, Kristen R Williams, Christopher G Pelic, James Fox, Gregory Sahlem, Sophie Robert, Gonzalo J Revuelta, Edward Baron Short
Amantadine, which was originally developed as an antiviral medication, functions as a dopamine agonist in the central nervous system and consequently is utilized in the treatment of Parkinson disease, drug-induced extrapyramidal reactions, and neuroleptic malignant syndrome. For reasons that are not entirely understood, abrupt changes in amantadine dosage can produce a severe withdrawal syndrome. Existing medical literature describes case reports of amantadine withdrawal leading to delirium, which at times has progressed to neuroleptic malignant syndrome...
May 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28490910/optimizing-psychosocial-interventions-in-first-episode-psychosis-current-perspectives-and-future-directions
#4
REVIEW
Nicholas Jk Breitborde, Aubrey M Moe, Arielle Ered, Lauren M Ellman, Emily K Bell
Psychotic-spectrum disorders such as schizophrenia, schizoaffective disorder, and bipolar disorder with psychotic features are devastating illnesses accompanied by high levels of morbidity and mortality. Growing evidence suggests that outcomes for individuals with psychotic-spectrum disorders can be meaningfully improved by increasing the quality of mental health care provided to these individuals and reducing the delay between the first onset of psychotic symptoms and the receipt of adequate psychiatric care...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/28478998/characteristics-and-service-use-of-older-adults-with-schizoaffective-disorder-versus-older-adults-with-schizophrenia-and-bipolar-disorder
#5
Stephanie A Rolin, Kelly A Aschbrenner, Karen L Whiteman, Emily Scherer, Stephen J Bartels
OBJECTIVE: The purpose of this study was to determine if schizoaffective disorder in older adults is differentiated from schizophrenia and bipolar disorder with respect to community functioning, cognitive functioning, psychiatric symptoms, and service use. DESIGN: Secondary analysis of baseline data collected from the Helping Older People Experience Success psychosocial skills training and health management study. SETTING: Three community mental health centers in New Hampshire and Massachusetts...
April 3, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28470892/impact-of-irritability-a-2-year-observational-study-of-outpatients-with-bipolar-i-or-schizoaffective-disorder
#6
Lesley Berk, Karen T Hallam, Kamalesh Venugopal, Andrew James Lewis, David W Austin, Jayashri Kulkarni, Seetal Dodd, Anthony de Castella, Paul B Fitzgerald, Michael Berk
OBJECTIVES: Many people experience irritability when manic, hypomanic, or depressed, yet its impact on illness severity and quality of life in bipolar and schizoaffective disorders is poorly understood. This study aimed to examine the relationship between irritability and symptom burden, functioning, quality of life, social support, suicidality, and overall illness severity in a naturalistic cohort of people with bipolar I or schizoaffective disorder. METHODS: We used data from 239 adult outpatients with bipolar I or schizoaffective disorder in the Bipolar Comprehensive Outcomes Study (BCOS) - a non-interventional observational study with a 2-year follow-up period...
May 3, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28470106/associations-of-neurod2-polymorphisms-and-change-of-cognitive-dysfunctions-in-schizophrenia-and-schizoaffective-disorder-after-eight-weeks-of-antipsychotic-treatment
#7
Ilja Spellmann, Michael Riedel, Julia Städtler, Peter Zill, Michael Obermeier, Anja Cerovecki, Sandra Dehning, Rebecca Schennach, Maria Epple, Markus Opgen-Rhein, Norbert Müller, Brigitta Bondy, Hans-Jürgen Möller, Richard Musil
INTRODUCTION: NEUROD2 is a neurospecific helix-loop-helix transcription factor which has an impact on the regulation of glutamatergic and GABAergic genes. We investigated an association of NEUROD2 with neurocognitive dysfunctions in schizophrenia and schizoaffective disorder patients before and during treatment with different second-generation antipsychotics. METHODS: Patients were genotyped for four different polymorphisms of the NEUROD2 gene ((rs9889354(A/G), rs1877032(C/T), rs12453682(C/T) and rs11078918(C/G))...
May 4, 2017: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/28467520/transdiagnostic-associations-between-functional-brain-network-integrity-and-cognition
#8
Julia M Sheffield, Sridhar Kandala, Carol A Tamminga, Godfrey D Pearlson, Matcheri S Keshavan, John A Sweeney, Brett A Clementz, Dov B Lerman-Sinkoff, S Kristian Hill, Deanna M Barch
Importance: Cognitive impairment occurs across the psychosis spectrum and is associated with functional outcome. However, it is unknown whether these shared manifestations of cognitive dysfunction across diagnostic categories also reflect shared neurobiological mechanisms or whether the source of impairment differs. Objective: To examine whether the general cognitive deficit observed across psychotic disorders is similarly associated with functional integrity of 2 brain networks widely implicated in supporting many cognitive domains...
May 3, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28466749/the-impact-of-an-empowerment-intervention-on-people-with-schizophrenia-results-of-a-randomized-controlled-trial
#9
Abdalhadi Hasan, Mahmoud Musleh
AIMS: The aim of the study was to assess what empowerment intervention has on people with schizophrenia. METHODS: A randomized controlled trial was carried out between November 2015 and May 2016 involving 112 participants who had been diagnosed with schizophrenia. Patients, who were 18 years and above diagnosed with Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-V) schizophrenia or schizoaffective disorder from the outpatient mental health clinics in Jordan, were randomly assigned to take part in an intervention that consisted of receiving 6 weeks' worth of information booklets, with face to face discussions, while receiving their usual medication or allocated treatment as usual...
May 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28463241/serum-kynurenic-acid-is-reduced-in-affective-psychosis
#10
B E Wurfel, W C Drevets, S A Bliss, J R McMillin, H Suzuki, B N Ford, H M Morris, T K Teague, R Dantzer, J B Savitz
A subgroup of individuals with mood and psychotic disorders shows evidence of inflammation that leads to activation of the kynurenine pathway and the increased production of neuroactive kynurenine metabolites. Depression is hypothesized to be causally associated with an imbalance in the kynurenine pathway, with an increased metabolism down the 3-hydroxykynurenine (3HK) branch of the pathway leading to increased levels of the neurotoxic metabolite, quinolinic acid (QA), which is a putative N-methyl-d-aspartate (NMDA) receptor agonist...
May 2, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28454922/paliperidone-palmitate-once-monthly-maintains-improvement-in-functioning-domains-of-the-personal-and-social-performance-scale-compared-with-placebo-in-subjects-with-schizoaffective-disorder
#11
Dong-Jing Fu, Ibrahim Turkoz, David Walling, Jean-Pierre Lindenmayer, Nina R Schooler, Larry Alphs
OBJECTIVE: Evaluate the effect of paliperidone palmitate once-monthly (PP1M) injectable on the specific functioning domains of the Personal and Social Performance (PSP) scale in patients with schizoaffective disorder (SCA) participating in a long-term study. METHODS: This study (NCT01193153) included both in- and outpatient subjects with SCA experiencing an acute exacerbation of psychotic and mood symptoms. Subjects were treated with PP1M either as monotherapy or in combination with antidepressants or mood stabilizers during a 25-week open-label (OL) phase...
April 25, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28449560/assessment-of-the-latent-adverse-events-of-antipsychotic-treatment-using-a-subjective-questionnaire-in-japanese-patients-with-schizophrenia
#12
Masakazu Hatano, Hiroyuki Kamei, Azusa Kato, Ippei Takeuchi, Manako Hanya, Junji Uno, Shigeki Yamada, Kiyoshi Fujita, Nakao Iwata
Objective: The adverse effects of antipsychotic agents can have a marked influence on medication adherence. In this study, we. investigated the adverse events of antipsychotics that are less likely to be reported by patients and the reasons why such symptoms remain latent. Methods: Data were collected by interviewing patients using a subjective questionnaire, and the associations between unreported symptoms and background factors were investigated. Results: A total of 306 patients with schizophrenia or schizoaffective disorder were examined...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28434719/pituitary-volume-reduction-in-schizophrenia-following-cognitive-behavioural-therapy
#13
Preethi Premkumar, Danielle Bream, Adegboyega Sapara, Dominic Fannon, Anantha P Anilkumar, Elizabeth Kuipers, Veena Kumari
Cognitive behavioural therapy (CBT) for psychosis (CBTp) aims to lower the stress of psychotic symptoms. Given that the pituitary is involved in stress regulation, CBT-led stress reduction may be accompanied by a change in pituitary volume. This study aimed to determine whether CBTp reduces pituitary volume in schizophrenia. The relation between pre-therapy memory and CBTp-led pituitary volume change was also examined given that poor memory relates to a blunted cortisol awakening response, denoting impaired stress response, in schizophrenia...
April 20, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28419586/a-review-of-the-nutritional-challenges-experienced-by-people-living-with-severe-mental-illness-a-role-for-dietitians-in-addressing-physical-health-gaps
#14
REVIEW
S B Teasdale, K Samaras, T Wade, R Jarman, P B Ward
People experiencing a severe mental illness (SMI), such as schizophrenia, schizoaffective disorder, bipolar affective disorder or depression with psychotic features, have a 20-year mortality gap compared to the general population. This 'scandal of premature mortality' is primarily driven by preventable cardiometabolic disease, and recent research suggests that the mortality gap is widening. Multidisciplinary mental health teams often include psychiatrists, clinical psychologists, specialist mental health nurses, social workers and occupational therapists, offering a range of pharmacological and nonpharmacological treatments to enhance the recovery of clients who have experienced, or are experiencing a SMI...
April 17, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28419491/intrinsic-neural-activity-differences-among-psychotic-illnesses
#15
Matthew E Hudgens-Haney, Lauren E Ethridge, Justin B Knight, Jennifer E McDowell, Sarah K Keedy, Godfrey D Pearlson, Carol A Tamminga, Matcheri S Keshavan, John A Sweeney, Brett A Clementz
Individuals with psychosis have been reported to show either reduced or augmented brain responses under seemingly similar conditions. It is likely that inconsistent baseline-adjustment methods are partly responsible for this discrepancy. Using steady-state stimuli during a pro/antisaccade task, this study addressed the relationship between nonspecific and stimulus-related neural activity, and how these activities are modulated as a function of cognitive demands. In 98 psychosis probands (schizophrenia, schizoaffective disorder, and bipolar disorder with psychosis), neural activity was assessed during baseline and during a 5-s period in preparation for the pro/antisaccade task...
April 17, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28406662/explicit-and-implicit-reinforcement-learning-across-the-psychosis-spectrum
#16
Deanna M Barch, Cameron S Carter, James M Gold, Sheri L Johnson, Ann M Kring, Angus W MacDonald, Diego A Pizzagalli, J Daniel Ragland, Steven M Silverstein, Milton E Strauss
Motivational and hedonic impairments are core features of a variety of types of psychopathology. An important aspect of motivational function is reinforcement learning (RL), including implicit (i.e., outside of conscious awareness) and explicit (i.e., including explicit representations about potential reward associations) learning, as well as both positive reinforcement (learning about actions that lead to reward) and punishment (learning to avoid actions that lead to loss). Here we present data from paradigms designed to assess both positive and negative components of both implicit and explicit RL, examine performance on each of these tasks among individuals with schizophrenia, schizoaffective disorder, and bipolar disorder with psychosis, and examine their relative relationships to specific symptom domains transdiagnostically...
April 13, 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28392649/drug-reaction-with-eosinophilia-and-systemic-symptom-syndrome-induced-by-lamotrigine
#17
Song Hee Han, Min Seok Hur, Hae Jeong Youn, Nam Kyung Roh, Yang Won Lee, Yong Beom Choe, Kyu Joong Ahn
Drug reaction with eosinophilia and systemic symptom (DRESS) syndrome is a type of severe adverse drug-induced reaction. Dermatologists should make a quick diagnosis and provide appropriate treatment for DRESS syndrome to reduce mortality rates, which can be as high as 10%. We present the case of a 47-year-old man with schizoaffective disorder treated with lamotrigine who developed DRESS syndrome to emphasize the importance of close observation of patients with drug eruption. He was consulted for erythematous maculopapular rashes on the trunk that developed 3 weeks after starting lamotrigine...
April 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28390849/cognitive-burden-of-anticholinergic-medications-in-psychotic-disorders
#18
Seenae Eum, S Kristian Hill, Leah H Rubin, Ryan M Carnahan, James L Reilly, Elena I Ivleva, Sarah K Keedy, Carol A Tamminga, Godfrey D Pearlson, Brett A Clementz, Elliot S Gershon, Matcheri S Keshavan, Richard S E Keefe, John A Sweeney, Jeffrey R Bishop
BACKGROUND: Patients with psychotic disorders are often treated with numerous medications, many of which have anticholinergic activity. We assessed cognition in relation to the cumulative anticholinergic burden of multiple drugs included in treatment regimens of participants from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study. METHOD: Clinically stable participants with schizophrenia (n=206), schizoaffective disorder (n=131), and psychotic bipolar disorder (n=146) were examined...
April 5, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28381728/the-effects-of-psychoeducation-on-long-term-inpatients-with-schizophrenia-and-schizoaffective-disorder
#19
Nobuhiko Yanagida, Toshiro Uchino, Naohisa Uchimura
This study aimed to examine the significance of intervention to improve medication adherence in long-term inpatients by providing psychoeducation and then elucidating the effects of this training in terms of patient knowledge and attitudes. Subjects were patients who had been hospitalized for more than 1 year after being admitted to a psychiatric hospital, had been diagnosed as F2 (schizophrenia, schizoaffective disorder) according to the International Classification of Diseases, 10th Edition, and were capable of verbal communication...
May 8, 2017: Kurume Medical Journal
https://www.readbyqxmd.com/read/28381222/assessment-of-the-consequences-of-caregiving-in-psychosis-a-psychometric-comparison-of-the-zarit-burden-interview-zbi-and-the-involvement-evaluation-questionnaire-ieq
#20
Manuel Gonçalves-Pereira, Eduardo González-Fraile, Borja Santos-Zorrozúa, Manuel Martín-Carrasco, Paola Fernández-Catalina, Ana I Domínguez-Panchón, Paula Muñoz-Hermoso, Javier Ballesteros
BACKGROUND: The Zarit Burden Interview (ZBI) was originally developed to assess the level of subjective burden in caregivers of people with dementia. The Involvement Evaluation Questionnaire (IEQ) is amongst the leading scales to assess caregiving consequences in severe mental illness. We aimed to compare the psychometric properties of the ZBI, a generic tool, and of the IEQ, a more specific tool to assess the consequences of caregiving in schizophrenia and related disorders. METHODS: Secondary analyses of a 16-week, randomized controlled trial of a psychoeducational intervention in 223 primary caregivers of patients with schizophrenia or schizoaffective disorder...
April 5, 2017: Health and Quality of Life Outcomes
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