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Ovarian hyperstimulation syndrome

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https://www.readbyqxmd.com/read/29446481/clinical-parameters-of-ovarian-hyperstimulation-syndrome-ohss-following-different-hormonal-triggers-of-oocyte-maturation-in-ivf-treatment
#1
A Abbara, R Islam, S A Clarke, L Jeffers, G Christopoulos, A N Comninos, R Salim, S A Lavery, N L Vuong, P Humaidan, T W Kelsey, G H Trew, W S Dhillo
OBJECTIVE: Ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic condition, predominantly related to the hormone used to induce oocyte maturation during IVF treatment. Kisspeptin is a hypothalamic neuropeptide that has recently been demonstrated to safely trigger final oocyte maturation during IVF treatment even in women at high risk of OHSS. However to date, the safety of kisspeptin has not been compared to current hormonal triggers of oocyte maturation. DESIGN: We conducted a retrospective single-centre cohort study investigating symptoms and clinical parameters of early OHSS in women at high risk of OHSS (antral follicle count or total number of follicles on day of trigger ≥23) triggered with hCG (n=40), GnRH agonist (GnRHa; n=99), or kisspeptin (n=122) at Hammersmith Hospital IVF unit, London, UK (2013-2016)...
February 15, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29439093/dysregulated-genes-and-their-functional-pathways-in-luteinized-granulosa-cells-from-pcos-patients-after-cabergoline-treatment
#2
Hortensia Ferrero, Patricia Diaz-Gimeno, Patricia Sebastian-Leon, Amparo Faus, Raul Gómez, Antonio Pellicer
Polycystic ovarian syndrome (PCOS) is a common reproductive disorder frequently associated with a substantial risk factor for ovarian hyperstimulation syndrome (OHSS). Dopamine receptor 2 (D2) agonists, like Cabergoline (Cb2), have been used to reduce the OHSS risk. However, lutein granulosa cells (LGCs) from PCOS patients treated with Cb2 still show a deregulated dopaminergic tone (decreased D2 expression and low dopamine production) and increased vascularization compared to non-PCOS LGCs. Therefore, to understand the PCOS ovarian physiology, it is important to explore the mechanisms that underlie syndrome based on the therapeutic effects of Cb2...
February 9, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29436143/infertility-treatment-strategy-involving-combined-freeze-all-embryos-and-single-vitrified-warmed-embryo-transfer-during-hormonal-replacement-cycle-for-in-vitro-fertilization-of-women-with-hypogonadotropic-hypogonadism
#3
Keiji Kuroda, Kenji Ezoe, Keiichi Kato, Akiko Yabuuchi, Tomoya Segawa, Tamotsu Kobayashi, Asako Ochiai, Noriko Katoh, Satoru Takeda
AIM: Hypogonadotropic hypogonadism (HH) is a condition caused by the deficient secretion of pituitary gonadotropins, leading to diminished ovarian function. Several studies of in vitro fertilization (IVF) in women with HH revealed acceptable clinical pregnancy outcomes but high multiple pregnancy rates after multiple fresh embryo transfer (ET). The purpose of this study was to analyze the outcomes of combined freeze-all embryos and single vitrified-warmed ET in women with HH. METHODS: Of 91 infertile women with HH (basal luteinizing hormone and follicle-stimulating hormone levels <2...
February 13, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29421437/effects-of-acupuncture-on-the-levels-of-serum-estradiol-and-pituitary-estrogen-receptor-beta-in-a-rat-model-of-induced-super-ovulation
#4
Haiyang Fu, Jianhua Sun, Yong Tan, Huifang Zhou, Wanli Xu, Junling Zhou, Dong Chen, Cong Zhang, Xuanxuan Zhu, Ying Zhang, Xiaoliang Wu, Zhaoqing Xi
AIMS: Acupuncture is frequently recommended as a complementary therapy for infertility. However, whether acupuncture can prevent early ovarian hyperstimulation syndrome has not been examined and its potential mechanisms are not well understood. MAIN METHODS: Forty rats were randomized into four groups: Control, Ovarian Stimulation Model, Acupuncture, and Human Chorionic Gonadotropin (HCG). Serum estradiol, progesterone, testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) levels were measured by enzyme-linked immunosorbent assay...
February 5, 2018: Life Sciences
https://www.readbyqxmd.com/read/29411339/evaluation-of-complications-developing-during-and-after-transvaginal-ultrasound-guided-oocyte-retrieval
#5
Selin Özaltın, Serkan Kumbasar, Kadir Savan
OBJECTIVES: To investigate the complications of the oocyte retrieval procedure currently used in in vitro fertilisation. MATERIAL AND METHODS: We examined 1.031 patients who underwent oocyte retrieval in the IVF unit of our hospital for complications developed during and after the procedure. RESULTS: No complications developed related to sedation or general anaesthesia. Vaginal bleeding was observed in 3.1% of the patients. There was no intra-abdominal bleeding or pelvic organ injuries requiring surgery...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29404536/low-dose-hcg-as-trigger-day-and-35-hr-later-have-different-ovarian-hyperstimulation-syndrome-occurrence-in-females-undergoing-in-vitro-fertilization-an-rct
#6
Marzieh Aghahosseini, Ashraf Aleyasin, Venus Chegini, Victoria Chegini
Background: Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication, which can cause high morbidity and mortality. Use of gonadotropin releasing hormone (GnRH) agonist instead of human chorionic gonadotropin (hCG) in GnRH antagonist cycles causes luteinizing hormone surge by GnRH stimulation which reduces the risk of OHSS by reducing the total amount of gonadotropin; however, there is no possibility of transferring fresh embryos. Objective: The current study aimed to evaluate the effect of hCG along with GnRH agonist administration in the occurrence of OHSS and pregnancy rate in females undergoing in vitro fertilization...
November 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29399762/the-effects-of-supraphysiological-estrogen-levels-on-ventricular-repolarization-parameters
#7
Omer Yiginer, Mehmet Dogan, Ismet Gun, Huseyin Tayfun Kutlu, Gokhan Degirmencioglu, İlkin Guliyev, Alptug Tokatli, Fethi Kilicaslan
BACKGROUND: The frequency of arrhythmic death developing without a structural cardiac disease is higher in women. Also female gender is an independent risk factor regarding developing Torsades des Pointes. Several studies have been conducted on the effects of physiological and therapeutic sex hormones on cardiac conduction system. AIM: In this study we aim to examine the effect of hormonal changes occurring during in vitro fertilization treatment and especially supraphysiological E2 levels on ventricular repolarization parameters...
February 5, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29391290/ureteral-obstruction-and-ruptured-kidney-following-ovarian-hyperstimulation-syndrome
#8
Alice Thoreau, Phuong Lien Tran, Marc Gabriele, Hélène Flye Sainte Marie, Malik Boukerrou
In vitro fertilization (IVF) is nowadays a reliable and common method for couple who need medically assisted procreation. Complications are rare. We report in this paper, the case of a woman with severe endometriosis who developed ureteral obstruction complicated by a renal rupture of the fornix due to ovarian hyperstimulation during an IVF attempt. The condition was diagnosed by CT scan and resolved with insertion of double-J catheter in the left ureter.
January 29, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29388198/individualised-gonadotropin-dose-selection-using-markers-of-ovarian-reserve-for-women-undergoing-in-vitro-fertilisation-plus-intracytoplasmic-sperm-injection-ivf-icsi
#9
REVIEW
Sarah F Lensen, Jack Wilkinson, Jori A Leijdekkers, Antonio La Marca, Ben Willem J Mol, Jane Marjoribanks, Helen Torrance, Frank J Broekmans
BACKGROUND: During a cycle of in vitro fertilisation plus intracytoplasmic sperm injection (IVF/ICSI), women receive daily doses of gonadotropin follicle-stimulating hormone (FSH) to induce multifollicular development in the ovaries. Generally, the dose of FSH is associated with the number of eggs retrieved. A normal response to stimulation is often considered desirable, for example the retrieval of 5 to 15 oocytes. Both poor and hyper-response are associated with increased chance of cycle cancellation...
February 1, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29386731/severe-ovarian-hyperstimulation-syndrome-can-we-eliminate-it-through-a-multipronged-approach
#10
Nikita Naredi, S K Singh, Prasad Lele, N Nagraj
Background: Prevention of severe Ovarian Hyperstimulation Syndrome (OHSS), a potentially fatal complication of controlled ovarian hyperstimulation has been the aim of all fertility experts. Various pharmacologic and non-pharmacologic interventions have been instituted but the results have been conflicting. These preventive strategies were administered in isolation or as a combination of few aiming to eliminate this iatrogenic sequel. This study aimed to eliminate severe OHSS by multipronged approach incorporating almost all preventive modalities available in patients at high risk for this dreadful complication...
January 2018: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/29349392/ovarian-hyperstimulation-syndrome-as-a-rare-cause-of-acute-bilateral-limb-and-renal-ischemia
#11
Anita Quintas, Maria Emilia Ferreira, Frederico Bastos Gonçalves, José Aragão de Morais, Joao Albuquerque E Castro, Luís Mota Capitao
Ovarian hyperstimulation syndrome (OHS) is a rare and potentially fatal condition, particularly when it is associated with arterial thromboembolic events. We present a case of acute ischemia of both lower limbs and left kidney due to OHS. The clinical presentation included voluminous ascites, pleural effusion, and significant ovarian enlargement. Subsequently, bilateral severe acute limb ischemia and left kidney segmental infarction were established. Surgical thromboembolectomy and muscle débridement of the lower limbs were necessary, and the patient recovered with partial limitations...
June 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29345163/low-dose-hp-hmg-in-an-antagonist-protocol-for-ivf-in-ovulatory-and-anovulatory-patients-with-high-amh
#12
Negjyp Sopa, Elisabeth Clare Larsen, Anders Nyboe Andersen
Women with high-AMH levels have an increased risk of ovarian hyperstimulation syndrome (OHSS). Studies have suggested that highly purified menotropin (HP-hMG) Menopur® reduces the risk. We, therefore, studied use of low-dose (112.5 IU/day) HP-hMG in ovulatory and anovulatory patients with high AMH (>32 pmol/L). The primary endpoint was the distribution of patients with appropriate, excessive, and inadequate response (5-14, ≥15, and ≤4 oocytes). Another endpoint was frequency of OHSS. Totally 115 women were included and 78 (67...
January 18, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29334275/laparoscopic-ovarian-drilling-versus-gnrh-antagonist-combined-with-cabergoline-as-a-prophylaxis-against-the-re-development-of-ovarian-hyperstimulation-syndrome
#13
Emaduldin Seyam, Enas Hefzy
OBJECTIVE: The aim of this work was to investigate the value of laparoscopic ovarian drilling (LOD) compared with GnRH antagonist flexible protocol combined with cabergoline (Cb), as a prophylaxis against the re-development of ovarian hyperstimulation syndrome (OHSS) in women with clomiphene citrate-resistant polycystic ovary disease (CCR-PCOD) who had severe OHSS before in a previous ICSI cycle. STUDY DESIGN: It is a prospective controlled study, where 250 CCR-PCOD women (n = 250) with a history of severe OHSS before, had been recruited for the study...
January 15, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29334199/comparison-of-cabergoline-and-quinagolide-in-prevention-of-severe-ovarian-hyperstimulation-syndrome-among-patients-undergoing-intracytoplasmic-sperm-injection
#14
Robabeh Taheripanah, Mahshid Vasef, Marzieh Zamaniyan, Anahita Taheripanah
Background: The aim of the current study is to compare quinagolide with cabergoline in prevention of ovarian hyperstimulation syndrome (OHSS) among high risk women undergoing intracytoplasmic sperm injection (ICSI). MATERIALS AND METHODS: This randomized clinical trial study was performed from March 2015 to February 2017. One hundred and twenty six women undergoing ICSI who were at high risk of developing OHSS (having over 20 follicles of >12 mm), were randomized into two groups...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29322719/life-threatening-medical-complications-due-to-ovarian-hyperstimulation-syndrome-a-hidden-etiology
#15
Prerana N Bhavsar, Namita J Padwal, Madhura Bhide, Santosh P Ghagare, Anagha R Joshi, Niteen D Karnik
Ovarian hyperstimulation syndrome is usually an iatrogenic complication in women taking ovulation induction medications during assisted reproduction. We hereby report the case of a 25 years old female who presented with hypertension, polyserositis with tense ascites and large cystic ovaries. She developed sigmoid and transverse sinus thrombosis. She had undergone a clandestine ovulation induction therapy as a commercial ovum donor. She fitted in severe category of ovarian hyperstimulation syndrome.
November 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29320646/transfer-of-fresh-versus-frozen-embryos-in-ovulatory-women
#16
RANDOMIZED CONTROLLED TRIAL
Yuhua Shi, Yun Sun, Cuifang Hao, Heping Zhang, Daimin Wei, Yunshan Zhang, Yimin Zhu, Xiaohui Deng, Xiujuan Qi, Hong Li, Xiang Ma, Haiqin Ren, Yaqin Wang, Dan Zhang, Bo Wang, Fenghua Liu, Qiongfang Wu, Ze Wang, Haiyan Bai, Yuan Li, Yi Zhou, Mei Sun, Hong Liu, Jing Li, Lin Zhang, Xiaoli Chen, Songying Zhang, Xiaoxi Sun, Richard S Legro, Zi-Jiang Chen
BACKGROUND: Elective frozen-embryo transfer has been shown to result in a higher live-birth rate than fresh-embryo transfer among anovulatory women with the polycystic ovary syndrome. It is uncertain whether frozen-embryo transfer increases live-birth rates among ovulatory women with infertility. METHODS: In this multicenter, randomized trial, we randomly assigned 2157 women who were undergoing their first in vitro fertilization cycle to undergo either fresh-embryo transfer or embryo cryopreservation followed by frozen-embryo transfer...
January 11, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29300975/new-application-of-dydrogesterone-as-a-part-of-a-progestin-primed-ovarian-stimulation-protocol-for-ivf-a-randomized-controlled-trial-including-516-first-ivf-icsi-cycles
#17
Sha Yu, Hui Long, Hannah Ya-Ning Chang, Yali Liu, Hongyuan Gao, Jing Zhu, Xinxin Quan, Qifeng Lyu, Yanping Kuang, Ai Ai
STUDY QUESTION: Can dydrogesterone (DYG) be used as an alternative progestin in a progesterone primed ovarian stimulation (PPOS) protocol? SUMMARY ANSWER: DYG can be used as an appropriate alternative progestin in a PPOS protocol. WHAT IS KNOWN ALREADY: PPOS is a new ovarian stimulation regimen based on a freeze-all strategy that uses progestin as an alternative to a GnRH analog for suppressing a premature LH surge during the follicular phase...
December 29, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29279182/elective-frozen-thawed-embryo-transfer-fet-in-women-at-risk-for-ovarian-hyperstimulation-syndrome
#18
J Zech, A Brandao, M Zech, K Lugger, S Neururer, H Ulmer, E Ruttmann
Elective cryopreservation of cultured embryos has become a treatment option for women at risk for ovarian hyperstimulation syndrome (OHSS). The aim of our study was to investigate the outcome of elective cryopreservation and consecutive frozen-thawed embryo transfer (FET) in a large IVF clinic in Austria. A total of 6104 controlled ovarian hyperstimulation cycles (COH) were performed on 2998 patients including 200 patients (6.7%) who were undergoing elective cryopreservation and FET due to high risk of OHSS...
December 24, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/29259490/age-specific-serum-anti-m%C3%A3-llerian-hormone-concentration-in-japanese-women-and-its-usefulness-as-a-predictor-of-the-ovarian-response
#19
Yoshimasa Asada, Yoshiharu Morimoto, Yoshiharu Nakaoka, Takahiro Yamasaki, Yutaka Suehiro, Hikaru Sugimoto, Masayuki Yoshida, Minoru Irahara
Purpose: To compare the ovarian response predictive ability of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), and estradiol (E2) and to determine the age-specific distribution of serum AMH concentrations of Japanese women. Methods: This was a multicenter (four-site), observational, analytic, cross-sectional Japanese study consisting of two parts: Study 1 (the prediction of the ovarian response of 236 participants who were undergoing controlled ovarian stimulation [COS]) and Study 2 (the distribution of the AMH concentration with an assay of 417 healthy women who were aged 20-49 years and who had normal menstrual cycles)...
October 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29259461/treatment-period-and-medical-care-costs-to-achieve-the-first-live-birth-by-assisted-reproductive-technology-are-lower-in-the-single-embryo-transfer-period-than-in-the-double-embryo-transfer-period-a-retrospective-analysis-of-women-younger-than-40%C3%A2-years-of
#20
Shunsuke Kawahara, Akane Ueda, Takashi Nakahori, Tetsuro Honda
Aim: It was examined whether the single embryo transfer policy makes the treatment period longer for couples to achieve their first live birth by assisted reproductive technology. Methods: This study retrospectively analyzed women who started assisted reproductive technology at younger than 40 years of age in the authors' organization. The treatment periods for couples to achieve the first live birth by assisted reproductive technology, between the women who started assisted reproductive technology from 2004 to 2009 (the double embryo transfer period group, n=250), in which the double embryo transfer was predominant, and the women who started assisted reproductive technology from 2010 to 2015 (the single embryo transfer period group, n=298), in which the single embryo transfer was predominant, were compared...
April 2017: Reproductive Medicine and Biology
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