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https://www.readbyqxmd.com/read/29159811/a-deep-learning-method-for-classifying-mammographic-breast-density-categories
#1
Aly A Mohamed, Wendie A Berg, Hong Peng, Yahong Luo, Rachel C Jankowitz, Shandong Wu
PURPOSE: Mammographic breast density is an established risk marker for breast cancer and is visually assessed by radiologists in routine mammogram image reading, using four qualitative Breast Imaging and Reporting Data System (BI-RADS) breast density categories. It is particularly difficult for radiologists to consistently distinguish the two most common and most variably assigned BI-RADS categories, i.e., "scattered density" and "heterogeneously dense". The aim of this work was to investigate a deep learning-based breast density classifier to consistently distinguish these two categories, aiming at providing a potential computerized tool to assist radiologists in assigning a BI-RADS category in current clinical workflow...
November 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/29144801/utility-of-a-single-late-night-plasma-cortisol-and-acth-for-the-diagnosis-of-cushing-s-syndrome
#2
Kush Dev Singh Jarial, Anil Bhansali, Kanchan K Mukherjee, Rimesh Pal, Akhilesh Sharma, Rakesh K Vashishtha, Suja P Sukumar, Naresh Sachdeva, Rama Walia
OBJECTIVE: To evaluate the diagnostic efficacy of various screening tests for the diagnosis of Cushing's syndrome (CS). METHODS: 35 patients of Cushing's syndrome and 16 patients of pseudo-Cushing's syndrome were enrolled. Assessment of 24h urinary free cortisol (UFC), late night salivary cortisol (LNSC), over night dexamethasone suppression test (ONDST), late night plasma cortisol (LNPC) and ACTH on outpatient basis, and during sleep as well as in awake state after 48 hours of hospital admission...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29144107/safe-return-to-driving-following-severe-acquired-brain-injury-role-of-a-short-neuropsychological-assessment
#3
Donatella Saviola, Antonio DE Tanti, Jessica Conforti, Lucio Posteraro, Alessia Manfredini, Chiara Bagattini, Benedetta Basagni
BACKGROUND: Driving is a complex ability requiring a broad range of motor, cognitive- behavioural and visual skills that may be impaired after severe Acquired Brain Injury (sABI). Resumption of driving is perceived as a major need by patients, being closely linked to personal autonomy, work and social activities. AIM: The objective of this study was to identify a short battery of neuropsychological tests with predictive value with regard to safe return to driving after sABI...
November 16, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29135060/a-study-to-determine-the-prevalence-of-temporomandibular-disorders-in-a-young-adult-population-and-its-association-with-psychological-and-functional-occlusal-parameters
#4
Hemant Maheshkumar Jivnani, Shuchi Tripathi, Rama Shanker, Balendra Pratap Singh, Kaushal Kishor Agrawal, Rameshwari Singhal
PURPOSE: To determine the prevalence of temporomandibular disorders (TMD) in medical university students and to analyze the relationship of TMD with psychological and functional occlusal parameters. MATERIALS AND METHODS: 200 students (mean age 21.81 ± 1.99) were screened for TMD with the TMD Pain Screener. Clinical examinations identified the participants with TMD. Based on their diagnostic criteria for TMD (DC/TMD) axis I diagnosis, participants were divided into three groups: group 1- non-TMD, group 2- pain related TMD and headaches, and group 3- intra-articular joint disorders...
November 14, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29134629/proton-pump-inhibitor-use-and-dementia-risk-prospective-population-based-study
#5
Shelly L Gray, Rod L Walker, Sascha Dublin, Onchee Yu, Erin J Aiello Bowles, Melissa L Anderson, Paul K Crane, Eric B Larson
OBJECTIVES: To determine whether higher cumulative proton pump inhibitor (PPI) exposure is associated with greater dementia risk. DESIGN: Prospective population-based cohort study. SETTING: Kaiser Permanente Washington, an integrated healthcare delivery system in Seattle, Washington. PARTICIPANTS: Individuals aged 65 and older without dementia at study entry (N = 3,484). MEASUREMENTS: Participants were screened for dementia every 2 years, and those who screened positive underwent extensive evaluation...
November 14, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29111816/comparing-the-response-to-acute-and-chronic-exposure-to-short-wavelength-lighting-emitted-from-computer-screens
#6
A Green, M Cohen-Zion, A Haim, Y Dagan
The use of electronic devices with light-emitting screens has increased exponentially in the last decade. As a result, humans are continuously exposed to unintentional artificial light. We explored the effects of acute and chronic exposure to artificial light at night (ALAN) via screen illumination on sleep, circadian rhythms, and related functional outcomes. Nineteen participants (11 female and 8 males, mean age 28.1 ± 7.2 years) underwent a six-night study with three experimental conditions using a repeated-measures design: baseline (first night, no light exposure), acute ALAN exposure (second night), and chronic ALAN exposure (third to sixth nights)...
November 7, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29108126/high-sensitivity-of-the-hematoflow%C3%A2-solution-for-chronic-myelomonocytic-leukemia-screening
#7
Romain Vazquez, Mikael Roussel, Bouchra Badaoui, Nicolas Freynet, Sihem Tarfi, Eric Solary, Dorothée Selimoglu-Buet, Orianne Wagner-Ballon
BACKGROUND: Accumulation of classical monocytes CD14(++) CD16(-) (also called MO1) ≥94% can accurately distinguish chronic myelomonocytic leukemia (CMML) from reactive monocytosis. The HematoFlow™ solution, able to quantify CD16 negative monocytes, could be a useful tool to manage monocytosis which remains a common issue in routine laboratories. METHODS: Classical monocytes were quantified from 153 whole blood samples collected on EDTA using both flow cytometry methods, either MO1 percentage determination by the multiparameter assay previously published and regarded here as the reference method, or CD16 negative monocyte percentage determination by the means of HematoFlow™...
November 6, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29107890/potentially-inappropriate-prescribing-according-to-stopp-2-criteria-among-patients-discharged-from-internal-medicine-prevalence-involved-drugs-and-economic-cost
#8
Alfredo José Pardo-Cabello, Victoria Manzano-Gamero, Mónica Zamora-Pasadas, Francisco Gutiérrez-Cabello, David Esteva-Fernández, Juan de Dios Luna-Del Castillo, Juan Jiménez-Alonso
AIM: This study aims to determine the prevalence of potentially inappropriate prescribing (PIP) among patients discharged from Internal Medicine, the drugs and factors associated and economic cost of PIP. METHODS: This retrospective cross-sectional, single-center study included participants aged ≥65 years consecutively discharged from the Internal Medicine Unit in a tertiary hospital of Southern Spain. PIP was defined by the Screening Tool for Older Persons Prescriptions (STOPP-2) criteria version 2 (2015 update)...
November 2, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29105791/implementation-of-dosimetry-equipment-and-phantoms-at-the-medaustron-light-ion-beam-therapy-facility
#9
Loϊc Grevillot, Markus Stock, Hugo Palmans, Jhonnatan Osorio Moreno, Virgile Letellier, Ralf Dreindl, Alessio Elia, Hermann Fuchs, Antonio Carlino, Stanislav Vatnitsky
PURPOSE: To describe the implementation of dosimetry equipment and phantoms into clinical practice of light ion beam therapy facilities. This work covers standard dosimetry equipment such as computerized water scanners, films, 2D-array, thimble and plane parallel ionization chambers, but also dosimetry equipment specifically devoted to the pencil beam scanning delivery technique such as water columns, scintillating screens or multi-layer ionization chambers. METHOD: Advanced acceptance testing procedures developed at MedAustron and complementary to the standard acceptance procedures proposed by the manufacturer are presented...
November 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/29089888/effect-of-speed-of-processing-training-on-older-driver-screening-measures
#10
Ranmalee Eramudugolla, Kim M Kiely, Sidhant Chopra, Kaarin J Anstey
Objective: Computerized training for cognitive enhancement is of great public interest, however, there is inconsistent evidence for the transfer of training gains to every day activity. Several large trials have focused on speed of processing (SOP) training with some promising findings for long-term effects on daily activity, but no immediate transfer to other cognitive tests. Here, we examine the transfer of SOP training gains to cognitive measures that are known predictors of driving safety in older adults...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29089756/computerized-screening-for-cognitive-impairment-in-patients-with-copd
#11
Carlijn Campman, Dirk van Ranst, Jan Willem Meijer, Margriet Sitskoorn
PURPOSE: COPD is associated with cognitive impairment. These impairments should be diagnosed, but due to time- and budget-reasons, they are often not investigated. The aim of this study is to examine the viability of a brief computerized cognitive test battery, Central Nervous System Vital Signs (CNSVS), in COPD patients. PATIENTS AND METHODS: Patients with COPD referred to tertiary pulmonary rehabilitation were included. Cognitive functioning of patients was assessed with CNSVS before pulmonary rehabilitation and compared with age-corrected CNSVS norms...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29089407/growth-and-final-height-among-children-with-phenylketonuria
#12
MULTICENTER STUDY
Alena G Thiele, Ruth Gausche, Cornelia Lindenberg, Christoph Beger, Maria Arelin, Carmen Rohde, Ulrike Mütze, Johannes F Weigel, Klaus Mohnike, Christoph Baerwald, Markus Scholz, Wieland Kiess, Roland Pfäffle, Skadi Beblo
BACKGROUND AND OBJECTIVES: Growth is an important criterion to evaluate health in childhood and adolescence, especially in patients depending on special dietary treatment. Phenylketonuria (PKU) is the most common inherited disease of amino acid metabolism. Patients with PKU depend on a special phenylalanine-restricted diet, low in natural protein. The study aimed to evaluate growth, growth rate, and target height in 224 patients with PKU. METHODS: Retrospective, longitudinal analysis of standardized, yearly measurements of height, weight, and calculated growth rate (SD score [SDS]) of patients with PKU aged 0 to 18 years were conducted by using the national computerized CrescNet database...
November 2017: Pediatrics
https://www.readbyqxmd.com/read/29066447/impact-of-sustained-use-of-a-multifaceted-computerized-quality-improvement-intervention-for-cardiovascular-disease-management-in-australian-primary-health-care
#13
Bindu Patel, David Peiris, Tim Usherwood, Qiang Li, Mark Harris, Kathryn Panaretto, Nicholas Zwar, Anushka Patel
BACKGROUND: We evaluated a multifaceted, computerized quality improvement intervention for management of cardiovascular disease (CVD) risk in Australian primary health care. After completion of a cluster randomized controlled trial, the intervention was made available to both trial arms. Our objective was to assess intervention outcomes in the post-trial period and any heterogeneity based on original intervention allocation. METHODS AND RESULTS: Data from 41 health services were analyzed...
October 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29065953/lemborexant-a-dual-orexin-receptor-antagonist-dora-for-the-treatment-of-insomnia-disorder-results-from-a-bayesian-adaptive-randomized-double-blind-placebo-controlled-study
#14
Patricia Murphy, Margaret Moline, David Mayleben, Russell Rosenberg, Gary Zammit, Kate Pinner, Shobha Dhadda, Quan Hong, Luigi Giorgi, Andrew Satlin
STUDY OBJECTIVES: To identify dose(s) of lemborexant that maximize insomnia treatment efficacy while minimizing next-morning residual sleepiness and evaluate lemborexant effects on polysomnography (PSG) measures (sleep efficiency [SE], latency to persistent sleep [LPS], and wake after sleep onset [WASO]) at the beginning and end of treatment. METHODS: Adults and elderly subjects with insomnia disorder per the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition were enrolled in a multicenter, randomized, double-blind, placebo-controlled, Bayesian, adaptive, parallel-group study, receiving lemborexant (1, 2...
November 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29065541/screening-and-biosensor-based-approaches-for-lung-cancer-detection
#15
REVIEW
Lulu Wang
Early diagnosis of lung cancer helps to reduce the cancer death rate significantly. Over the years, investigators worldwide have extensively investigated many screening modalities for lung cancer detection, including computerized tomography, chest X-ray, positron emission tomography, sputum cytology, magnetic resonance imaging and biopsy. However, these techniques are not suitable for patients with other pathologies. Developing a rapid and sensitive technique for early diagnosis of lung cancer is urgently needed...
October 23, 2017: Sensors
https://www.readbyqxmd.com/read/29060485/automatic-picking-of-snore-events-from-overnight-breath-sound-recordings
#16
Vinayak R Swarnkar, Udantha R Abeyratne, Roneel V Sharan
Snoring is one of the earliest symptoms of Obstructive Sleep Apnea (OSA). However, the unavailability of an objective snore definition is a major obstacle in developing automated snore analysis system for OSA screening. The objectives of this paper is to develop a method to identify and extract snore sounds from a continuous sound recording following an objective definition of snore that is independent of snore loudness. Nocturnal sounds from 34 subjects were recorded using a non-contact microphone and computerized data-acquisition system...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29058014/quantitative-rapid-assessment-of-leukoaraiosis-in-ct-comparison-to-gold-standard-mri
#17
Uta Hanning, Peter Bernhard Sporns, Rene Schmidt, Thomas Niederstadt, Jens Minnerup, Georg Bier, Stefan Knecht, André Kemmling
PURPOSE: The severity of white matter lesions (WML) is a risk factor of hemorrhage and predictor of clinical outcome after ischemic stroke; however, in contrast to magnetic resonance imaging (MRI) reliable quantification for this surrogate marker is limited for computed tomography (CT), the leading stroke imaging technique. We aimed to present and evaluate a CT-based automated rater-independent method for quantification of microangiopathic white matter changes. METHODS: Patients with suspected minor stroke (National Institutes of Health Stroke scale, NIHSS < 4) were screened for the analysis of non-contrast computerized tomography (NCCT) at admission and compared to follow-up MRI...
October 20, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29049239/clinical-features-and-diagnosis-of-chronic-pulmonary-aspergillosis-in-chinese-patients
#18
Xiaomeng Hou, Hong Zhang, Lei Kou, Wei Lv, Jingjing Lu, Ji Li
Chronic pulmonary aspergillosis (CPA) has recently been recognized as a significant global health burden. In China, the diagnosis of CPA is still unfamiliar to most doctors. The aim of this study was to demonstrate the clinical manifestations and diagnoses of CPA in China.A multidisciplinary team of doctors retrospectively screened 690 records of patients diagnosed with pulmonary aspergillosis from January 2000 to December 2016 at Peking Union Medical College Hospital, Beijing, China. Of these, 69 patients were diagnosed with CPA...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048733/cytology-and-high-risk-hpv-testing-in-cervical-cancer-screening-program-outcome-of-3-year-follow-up-in-an-academic-institute
#19
Jack Yang, Fredrick S Nolte, Olga S Chajewski, Kathryn G Lindsey, Patricia M Houser, Jalidsa Pellicier, Qun Wang, Laleh Ehsani
BACKGROUND: Combination of cervical cytology and high-risk human papillomavirus (HR-HPV) testing, co-testing, has been increasingly used in screening cervical cancers. The present study summarized the outcome of co-testing by reviewing 3-year clinical and pathological follow-up information. METHODS: Patients were retrospectively identified via computerized search and were grouped based on the cytologic diagnosis and HR-HPV status as negative for intraepithelial lesion or malignancy (NILM)/HPV-, NILM/HPV+, atypical squamous cells of undetermined significance (ASC-US)/HPV-, ASC-US/HPV+, low grade squamous intraepithelial lesion (LSIL)/HPV-, LSIL/HPV+, atypical squamous cells, cannot exclude high grade squamous intraepithelial lesion (ASC-H)/HPV-, ASC-H/HPV+, high grade squamous intraepithelial lesion (HSIL)/HPV-, and HSIL/HPV+...
October 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29042060/australian-general-practitioners-initiate-statin-therapy-primarily-on-the-basis-of-lipid-levels-new-zealand-general-practitioners-use-absolute-risk
#20
REVIEW
Chris Schilling, Josh Knight, Duncan Mortimer, Dennis Petrie, Philip Clarke, John Chalmers, Andrew Kerr, Rod Jackson
OBJECTIVES: To compare the determinants of initial statin prescribing between New Zealand and Australia. New Zealand has a system-wide absolute risk-based approach to primary care cardiovascular disease (CVD) management, while Australia has multiple guidelines. METHOD: Classification and Regression Tree (CART) analysis of two observational studies of primary care CVD management from New Zealand (PREDICT-CVD) and Australia (AusHeart). Over 80% of eligible New Zealanders have been screened for CVD risk...
October 10, 2017: Health Policy
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