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https://www.readbyqxmd.com/read/28717060/clinical-data-analysis-of-genotypes-and-phenotypes-of-deafness-gene-mutations-in-newborns-a-retrospective-study
#1
Yating Du, Lihui Huang, Xueyao Wang, Qingjia Cui, Xiaohua Cheng, Liping Zhao, Tingting Ni
We retrospectively analyzed newborns with deafness gene mutations and summarized the relationship between genotype and phenotype to provide a basis for genetic counseling. We studied 582 subjects positive for deafness gene mutations that were treated in the otology outpatient department of Beijing Tongren Hospital, Capital Medical University, between April 2012 and April 2016. The subjects were divided into 3 categories: a diagnosed group (group A), which was further subdivided into subgroups A1 (homozygous and compound heterozygous GJB2 mutations) and A2 (homozygous and compound heterozygous SLC26A4 mutations); a drug-induced deafness group (group B, mitochondrial (Mt) gene mutations); and a mutation carrier group (group C), which was further subdivided into the subgroups C1 (GJB2 heterozygous mutations), C2 (SLC26A4 heterozygous mutations), C3 (GJB3 heterozygous mutations), and C4 (double gene mutations)...
July 17, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28716490/-self-evaluation-of-conization-indications-since-the-introduction-of-the-french-colposcopy-and-cervico-vaginal-pathology-quality-charter-in-2%C3%A2-colposcopy-centers
#2
M Lallemant, C Baeza, C Monnin, M Malincenco, C Gay
OBJECTIVES: Analyze the efficiency of the implementation of the colposcopy and cervico-vaginal pathology quality charter. The question was to determine whether the criteria of more than 70% of excisional conizations containing CIN2+ lesions (cervical intraepithelial neoplasia 2 or 3 or carcinoma in situ) had been reached and demonstrate a reduction of the conization rate is possible. METHODS: An epidemiological descriptive, retrospective and multicenter study was performed in "Nord Franche-Comté Hospitals" (Belfort and Montbéliard, France) during the period from November 2013 to January 2015...
July 14, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28700902/a-novel-algorithm-to-detect-glaucoma-risk-using-texton-and-local-configuration-pattern-features-extracted-from-fundus-images
#3
U Rajendra Acharya, Shreya Bhat, Joel E W Koh, Sulatha V Bhandary, Hojjat Adeli
Glaucoma is an optic neuropathy defined by characteristic damage to the optic nerve and accompanying visual field deficits. Early diagnosis and treatment are critical to prevent irreversible vision loss and ultimate blindness. Current techniques for computer-aided analysis of the optic nerve and retinal nerve fiber layer (RNFL) are expensive and require keen interpretation by trained specialists. Hence, an automated system is highly desirable for a cost-effective and accurate screening for the diagnosis of glaucoma...
June 29, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28697206/an-overview-of-systematic-reviews-related-to-aspects-of-the-shortened-dental-arch-and-its-variants-in-adults
#4
Saadika B Khan, Usuf Me Chikte, Ridwaan Omar
PURPOSE: The aim of this study was to conduct an overview of systematic reviews (SRs) related to aspects of the shortened dental arch (SDA) and its variants and critically appraise the methodologic quality of included SRs using the AMSTAR checklist. MATERIALS AND METHODS: A comprehensive computerized search and a hand search of reference lists were conducted for SRs related to SDAs to identify publications from 2000 to 2016. All the present authors and a research assistant independently screened the results of the electronic searches using an eligibility form and extracted information using a specially designed prepiloted data extraction form...
July 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/28681432/computer-generated-reminders-delivered-on-paper-to-healthcare-professionals-effects-on-professional-practice-and-healthcare-outcomes
#5
REVIEW
Chantal Arditi, Myriam Rège-Walther, Pierre Durieux, Bernard Burnand
BACKGROUND: Clinical practice does not always reflect best practice and evidence, partly because of unconscious acts of omission, information overload, or inaccessible information. Reminders may help clinicians overcome these problems by prompting them to recall information that they already know or would be expected to know and by providing information or guidance in a more accessible and relevant format, at a particularly appropriate time. This is an update of a previously published review...
July 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28678153/early-diagnosis-of-breast-cancer
#6
REVIEW
Lulu Wang
Early-stage cancer detection could reduce breast cancer death rates significantly in the long-term. The most critical point for best prognosis is to identify early-stage cancer cells. Investigators have studied many breast diagnostic approaches, including mammography, magnetic resonance imaging, ultrasound, computerized tomography, positron emission tomography and biopsy. However, these techniques have some limitations such as being expensive, time consuming and not suitable for young women. Developing a high-sensitive and rapid early-stage breast cancer diagnostic method is urgent...
July 5, 2017: Sensors
https://www.readbyqxmd.com/read/28673411/neuropsychological-screening-of-sport-related-concussion
#7
REVIEW
Michael A McCrea, Breton Asken, Lindsay D Nelson
Neuropsychological assessment is a key component of the multidimensional approach recommended by international consensus guidelines for evaluation of athletes affected by sport-related concussion (SRC). Over the past 2 decades, a number of conventional and computerized neuropsychological test batteries have been developed for the assessment of SRC. Standardized neurocognitive assessment tools are now commonly used across the continuum of concussion care, ranging from the sports sideline to critical care setting and the outpatient concussion clinic...
August 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/28666201/screening-for-generalized-anxiety-disorder-in-spanish-primary-care-centers-with-the-gad-7
#8
Roger Muñoz-Navarro, Antonio Cano-Vindel, Juan Antonio Moriana, Leonardo Adrián Medrano, Paloma Ruiz-Rodríguez, Laura Agüero-Gento, Mónica Rodríguez-Enríquez, María Rosa Pizà, Jose Ignacio Ramírez-Manent
The aim of the study was to determine the criterion validity of a computerized version of the General Anxiety Disorder-7 (GAD-7) questionnaire to detect general anxiety disorder in Spanish primary care centers. A total of 178 patients completed the GAD-7 and were administered the Composite International Diagnostic Interview (CIDI) for DSM-IV Axis I Disorders, which was used as a reference standard. Sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios were calculated...
June 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28646784/premenstrual-mood-and-empathy-after-a-single-light-therapy-session
#9
Marije Aan Het Rot, Kristina Miloserdov, Anna L F Buijze, Ybe Meesters, Marijke C M Gordijn
To examine whether acute changes in cognitive empathy might mediate the impact of light therapy on mood, we assessed the effects of a single light-therapy session on mood and cognitive empathy in 48 premenstrual women, including 17 who met Premenstrual Symptoms Screening Tool criteria for moderate-to-severe premenstrual syndrome / premenstrual dysphoric disorder (PMS/PMDD). Using a participant-blind between-groups design, 23 women underwent 30min of morning light therapy (5,000lx; blue-enriched polychromatic light, 17,000K) while 25 women had a sham session (200lx, polychromatic light, 5,000K)...
June 16, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28641244/computerized-lung-sound-screening-for-pediatric-auscultation-in-noisy-field-environments
#10
Dimitra Emmanouilidou, Eric D McCollum, Daniel E Park, Mounya Elhilali
GOAL: Chest auscultations offer a non-invasive and low-cost tool for monitoring lung disease. However, they present many shortcomings including inter-listener variability, subjectivity, and vulnerability to noise and distortions. The current work proposes a computer-aided approach to process lung signals acquired in the field under adverse noisy conditions, by improving the signal quality and offering automated iden- tification of abnormal auscultations indicative of respiratory pathologies...
June 19, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28631969/cognitive-functions-among-predominantly-minority-urban-adolescents-with-metabolic-syndrome
#11
Alexander Mangone, Kathy F Yates, Victoria Sweat, Adriana Joseph, Antonio Convit
The rise in the rate of adolescent obesity has led to a concurrent rise in the rate of metabolic syndrome (MetS) among young people. In addition to diabetes and cardiovascular disease, MetS has also been linked to cognitive dysfunction. The goal of this study was to assess whether cognitive differences exist between minority urban adolescents carrying excess weight who meet criteria for MetS as compared to their peers without MetS. Two hundred and ninety-six urban adolescents, predominantly Hispanic and carrying excess weight as defined by a BMI above 25 kg/m(2), were screened for MetS and divided into MetS and no MetS groups...
February 22, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/28629461/cost-effectiveness-of-lung-cancer-screening-and-treatment-methods-a-systematic-review-of-systematic-reviews
#12
Farbod Ebadifard Azar, Saber Azami-Aghdash, Fatemeh Pournaghi-Azar, Alireza Mazdaki, Aziz Rezapour, Parvin Ebrahimi, Negar Yousefzadeh
BACKGROUND: Due to extensive literature in the field of lung cancer and their heterogeneous results, the aim of this study was to systematically review of systematic reviews studies which reviewed the cost-effectiveness of various lung cancer screening and treatment methods. METHODS: In this systematic review of systematic reviews study, required data were collected searching the following key words which selected from Mesh: "lung cancer", "lung oncology", "lung Carcinoma", "lung neoplasm", "lung tumors", "cost- effectiveness", "systematic review" and "Meta-analysis"...
June 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28621616/prevalence-of-foramen-arcuale-and-its-clinical-significance-a-meta-analysis-of-55-985-subjects
#13
Przemysław A Pękala, Brandon M Henry, Jakub R Pękala, Wan Chin Hsieh, Jens Vikse, Beatrice Sanna, Jerzy A Walocha, R Shane Tubbs, Krzysztof A Tomaszewski
OBJECTIVE The foramen arcuale (FA) is a bony bridge located over the vertebral artery on the posterior arch of the atlas. The presence of an FA can pose a risk during neurosurgery by providing a false impression of a broader posterior arch. The aim of this study was to provide the most comprehensive investigation on the prevalence of the FA and its clinically important anatomical features. METHODS Major electronic databases were searched to identify all studies that reported relevant data on the FA and the data were pooled into a meta-analysis...
June 16, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28619702/computerized-childbirth-monitoring-tools-for-health-care-providers-managing-labor-a-scoping-review
#14
Michael S Balikuddembe, Nazarius M Tumwesigye, Peter K Wakholi, Thorkild Tylleskär
BACKGROUND: Proper monitoring of labor and childbirth prevents many pregnancy-related complications. However, monitoring is still poor in many places partly due to the usability concerns of support tools such as the partograph. In 2011, the World Health Organization (WHO) called for the development and evaluation of context-adaptable electronic health solutions to health challenges. Computerized tools have penetrated many areas of health care, but their influence in supporting health staff with childbirth seems limited...
June 15, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28610451/cognitive-function-is-largely-intact-in-methadone-maintenance-treatment-patients
#15
Odelia Elkana, Miriam Adelson, Glen M Doniger, Anat Sason, Einat Peles
OBJECTIVES: To confirm our previous findings of less cognitive impairments (based on cognitive screening tools) among methadone maintenance treatment (MMT) patients who achieved take-home dose (THD) privileges. METHODS: a random sample of 65 Israeli MMT patients were studied using computerised, age and education standardised, cognitive domains (attention, executive function, memory, motor skills), and non-computerised phonetic and semantic verbal fluency. RESULTS: Cognitive scores were within ±1 standard deviation (SD) of average for most domains, including non-verbal IQ, attention and motor skills...
July 5, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28607456/an-advanced-deep-learning-approach-for-ki-67-stained-hotspot-detection-and-proliferation-rate-scoring-for-prognostic-evaluation-of-breast-cancer
#16
Monjoy Saha, Chandan Chakraborty, Indu Arun, Rosina Ahmed, Sanjoy Chatterjee
Being a non-histone protein, Ki-67 is one of the essential biomarkers for the immunohistochemical assessment of proliferation rate in breast cancer screening and grading. The Ki-67 signature is always sensitive to radiotherapy and chemotherapy. Due to random morphological, color and intensity variations of cell nuclei (immunopositive and immunonegative), manual/subjective assessment of Ki-67 scoring is error-prone and time-consuming. Hence, several machine learning approaches have been reported; nevertheless, none of them had worked on deep learning based hotspots detection and proliferation scoring...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28601572/corpus-callosum-atrophy-as-a-marker-of-clinically-meaningful-cognitive-decline-in-secondary-progressive-multiple-sclerosis-impact-on-employment-status
#17
Athanasios Papathanasiou, Lambros Messinis, Petros Zampakis, Panagiotis Papathanasopoulos
Cognitive impairment in Multiple Sclerosis (MS) is more frequent and pronounced in secondary progressive MS (SPMS). Cognitive decline is an important predictor of employment status in patients with MS. Magnetic Resonance Imaging (MRI) markers have been used to associate tissue damage with cognitive dysfunction. The aim of the study was to designate the MRI marker that predicts cognitive decline in SPMS and explore its effect on employment status. 30 SPMS patients and 30 healthy participants underwent neuropsychological assessment using the Trail Making Test (TMT) parts A and B, semantic and phonological verbal fluency task and a computerized cognitive screening battery (Central Nervous System Vital Signs)...
June 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28596793/comparative-analysis-of-tongue-indices-between-patients-with-and-without-a-self-reported-yin-deficiency-a-cross-sectional-study
#18
Su-Ryun Kim, Woojin Choi, Inkwon Yeo, Dong-Hyun Nam
We investigated the hypothesis that Yin-deficient patients have a reddened tongue with less coating. We screened 189 participants aged 20 to 49 years, complaining of headache. To classify patients in terms of Yin deficiency, we used two self-reporting Yin-deficiency questionnaires (Yin-Deficiency Questionnaire and Yin-Deficiency Scale) and diagnosis by a doctor. Based on the tests, a total of 33 subjects were assigned to a Yin-deficient group and 33 subjects were assigned to a nondeficient control group. Tongue images were acquired using a computerized tongue diagnostic system, for evaluating tongue indices...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28589256/treatment-of-congenital-pulmonary-airway-malformations-a-systematic-review-from-the-apsa-outcomes-and-evidence-based-practice-committee
#19
Cynthia D Downard, Casey M Calkins, Regan F Williams, Elizabeth J Renaud, Tim Jancelewicz, Julia Grabowski, Roshni Dasgupta, Milissa McKee, Robert Baird, Mary T Austin, Meghan A Arnold, Adam B Goldin, Julia Shelton, Saleem Islam
PURPOSE: Variation in management characterizes treatment of infants with a congenital pulmonary airway malformation (CPAM). This review addresses six clinically applicable questions using available evidence to provide recommendations for the treatment of these patients. METHODS: Questions regarding the management of a pediatric patient with a CPAM were generated. English language articles published between 1960 and 2014 were compiled after searching Medline and OvidSP...
June 6, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28586420/appropriateness-criteria-for-the-use-of-cardiovascular-imaging-in-heart-valve-disease-in-adults-a-european-association-of-cardiovascular-imaging-report-of-literature-review-and-current-practice
#20
John B Chambers, Madalina Garbi, Koen Nieman, Saul Myerson, Luc A Pierard, Gilbert Habib, Jose Luis Zamorano, Thor Edvardsen, Patrizio Lancellotti, Dr Victoria Delgado, Prof Bernard Cosyns, Prof Erwan Donal, Dr Raluca Dulgheru, Dr Maurizio Galderisi, Dr Massimo Lombardi, Dr Denisa Muraru, Dr Philipp Kauffmann, Prof Nuno Cardim, Assoc Prof Kristina Haugaa, Dr Raphael Rosenhek
Heart valve disease is common and a major indication for imaging. Echocardiography is the first-line imaging technique for diagnosis, assessment, and serial surveillance. However, other modalities, notably cardiac magnetic resonance imaging and computerized tomography, are used if echocardiographic imaging is suboptimal or to obtain complementary information, particularly to aid risk assessment in individual patients. This review is a summary of current evidence for state-of-the-art clinical practice to inform appropriateness criteria for heart valve disease...
May 1, 2017: European Heart Journal Cardiovascular Imaging
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