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https://www.readbyqxmd.com/read/28904237/labetalol-use-is-associated-with-increased-in-hospital-infection-compared-with-nicardipine-use-in-intracerebral-hemorrhage
#1
Jordan B Starr, David L Tirschwell, Kyra J Becker
BACKGROUND AND PURPOSE: Increased sympathetic tone causes hypertension after intracerebral hemorrhage, and blood pressure reduction has been studied as a way to decrease hemorrhage growth and improve outcomes. It is unknown if the antihypertensive used to achieve blood pressure goals influences either. Because sympatholytic drugs reduce death and infection in animal models, we hypothesized that labetalol would improve outcomes compared with nicardipine. METHODS: Prospective data from a single center were retrospectively reviewed...
September 13, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28885414/urinary-symptoms-and-their-associations-with-urinary-tract-infections-in-urogynecologic-patients
#2
Tanaka J Dune, Travis K Price, Evann E Hilt, Krystal J Thomas-White, Stephanie Kliethermes, Cynthia Brincat, Linda Brubaker, Paul Schreckenberger, Alan J Wolfe, Elizabeth R Mueller
OBJECTIVE: To assess urinary symptoms associated with urinary tract infection (UTI) in a urogynecologic population of women. METHODS: In this cohort study, we enrolled 150 urogynecologic patients who completed the validated UTI Symptom Assessment questionnaire and contributed transurethral catheterized urine samples. The primary measure (UTI diagnosis) was defined in three ways. Self-report (a nonculture-based UTI diagnosis) was defined by a yes or no response to the query "Do you think you have a UTI?" Two culture-based UTI diagnoses also were analyzed: standard urine culture (10 colony-forming units [CFU]/mL or greater) and enhanced quantitative urine culture (10 CFU/mL or greater) of any uropathogen...
September 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28874628/ureterocele-fenestration-with-holmium-laser-in-neonates
#3
Predrag Ilic, Mirjana Jankovic, Maja Milickovic, Slobodan Dzambasanovic, Vladimir Kojovic
AIM: To evaluate the effectiveness of holmium-laser fenestration of intravesical ureteroceles in neonatal period. MATERIAL AND METHOD: We retrospectively analyzed the results of the holmium-laser puncture in ten neonates with intravesical ureterocele, between September 2013 and September 2016. Laser probe was placed through the cystoscope to the lowest and medial portion of the ureterocele, near the bladder floor. Few punctures (4 to 8) were made, until ureterocele has been collapsed...
June 23, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28832768/application-of-data-mining-techniques-to-explore-predictors-of-upper-urinary-tract-damage-in-patients-with-neurogenic-bladder
#4
H Fang, B Lu, X Wang, L Zheng, K Sun, W Cai
This study proposed a decision tree model to screen upper urinary tract damage (UUTD) for patients with neurogenic bladder (NGB). Thirty-four NGB patients with UUTD were recruited in the case group, while 78 without UUTD were included in the control group. A decision tree method, classification and regression tree (CART), was then applied to develop the model in which UUTD was used as a dependent variable and history of urinary tract infections, bladder management, conservative treatment, and urodynamic findings were used as independent variables...
August 17, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28791237/update-on-voiding-dysfunction-managed-with-suprapubic-catheterization
#5
REVIEW
Sharon F English
As the population ages the prevalence of long-term urinary catheters, especially in the elderly, is going to increase. Urinary catheters are usually placed to manage urinary retention or incontinence that cannot be managed any other way. There is significant morbidity associated with an indwelling catheter. The commonest problems are catheter blockages, infection and bladder stones. These will occur with a similar incidence with either a suprapubic or a urethral catheter. Urethral complications such as strictures, scrotal infection and erosion are less common with suprapubic catheterization (SPC)...
July 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28768589/journal-club-developing-a-user-friendly-report-for-electronically-assisted-surveillance-of-catheter-associated-urinary-tract-infections
#6
Michael Fritz Estinville, Amanda Hessels, James Davis
The article chosen for this Journal Club commentary describes the development and testing of a report format using automated data to report urinary catheter utilization and catheter-associated urinary tract infections (CAUTIs).(1) This research sought to address a gap in knowledge regarding the optimal display and content of data reports, communicating to diverse audiences, which used surveillance data from Department of Veterans Affairs' electronic health records. The specific research aim of this project was to develop and pilot test report formats deemed usable and trustworthy by the end user, and discover the best way to deliver to the ideal audience automated data, which is formatted and presented in a way that is acceptable to the end user...
August 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28746884/effects-of-single-and-combined-use-of-bacteriophages-and-antibiotics-to-inactivate-escherichia-coli
#7
Nádia Valério, Cristiana Oliveira, Vânia Jesus, Tatiana Branco, Carla Pereira, Catarina Moreirinha, Adelaide Almeida
A major concern of phage therapy is the emergency of phage-resistant mutants. This limitation can be overcome by the combined use of phages and antibiotics. It has been shown that the combination of antibiotics and phages is an alternative that cannot only be effective at reducing bacterial numbers, but also to contribute to the management of resistance levels. However, this view has only been discussed with regard to antibiotic resistance and not to control phage-mutant emergence. In our study we compared not only the resistance of the bacteria to the four antibiotics tested with and without phages addition, but also the resistance to the phages in the presence and absence of antibiotics...
July 23, 2017: Virus Research
https://www.readbyqxmd.com/read/28702844/influence-of-acetylsalicylic-acid-and-low-molecular-weight-heparins-on-the-formation-of-renal-hematoma-after-shock-wave-lithotripsy
#8
Christoph Schregel, Hubert John, Marco Randazzo, Isabelle Keller
PURPOSE: To investigate the risk of renal hematoma (RHT) after shock wave lithotripsy (SWL) among patients on acetylsalicylic acid (ASA) or low-molecular-weight heparin (LMWH). PATIENTS AND METHODS: Retrospective analysis of 434 patients treated with SWL for nephrolithiasis and ureterolithiasis of the proximal ureter. Primary endpoint was detection of RHT by ultrasound the day after SWL. Secondary outcome variables included transfusion of erythrocyte concentrate(s), interventions, hospital readmission or death due to RHT within 30 days of SWL...
July 12, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28579794/diagnostic-applications-of-nuclear-magnetic-resonance-based-urinary-metabolomics
#9
REVIEW
Ana Capati, Omkar B Ijare, Tedros Bezabeh
Metabolomics is a rapidly growing field with potential applications in various disciplines. In particular, metabolomics has received special attention in the discovery of biomarkers and diagnostics. This is largely due to the fact that metabolomics provides critical information related to the downstream products of many cellular and metabolic processes which could provide a snapshot of the health/disease status of a particular tissue or organ. Many of these cellular products eventually find their way to urine; hence, analysis of urine via metabolomics has the potential to yield useful diagnostic and prognostic information...
2017: Magnetic Resonance Insights
https://www.readbyqxmd.com/read/28533105/prevalence-of-overactive-bladder-and-its-impact-on-quality-of-life-in-1025-patients-with-type-2-diabetes-in-mainland-china
#10
Dongjuan Xu, Jie Gao, Xiaojuan Wang, Liqun Huang, Kefang Wang
AIMS: This study examined the prevalence of overactive bladder (OAB) and investigated the impact of OAB on quality of life (QOL) in patients with type 2 diabetes in Mainland China. METHODS: A total of 1025 patients with type 2 diabetes were surveyed. Patients were grouped into no OAB, dry OAB, and wet OAB groups according to the presence of OAB and urge incontinence. Descriptive analyses, one-way analysis of variance (ANOVA) and multivariable regression models were conducted to assess the prevalence of OAB and the effect of OAB on QOL...
May 10, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28506090/rational-design-strategies-for-fimh-antagonists-new-drugs-on-the-horizon-for-urinary-tract-infection-and-crohn-s-disease
#11
REVIEW
Laurel K Mydock-McGrane, Thomas J Hannan, James W Janetka
The bacterial adhesin FimH is a virulence factor and an attractive therapeutic target for urinary tract infection (UTI) and Crohn's Disease (CD). Located on type 1 pili of uropathogenic E. coli (UPEC), the FimH adhesin plays an integral role in the pathogenesis of UPEC. Recent efforts have culminated in the development of small-molecule mannoside FimH antagonists that target the mannose-binding lectin domain of FimH, inhibiting its function and preventing UPEC from binding mannosylated host cells in the bladder, thereby circumventing infection...
July 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28462447/predictive-power-of-the-nsqip-risk-calculator-for-early-post-operative-outcomes-after-whipple-experience-from-a-regional-center-in-northern-ontario
#12
Henry Y Jiang, Erica L Kohtakangas, Kengo Asai, Jeffrey B Shum
BACKGROUND: NSQIP Risk Calculator was developed to allow surgeons to inform their patients about their individual risks for surgery. Its ability to predict complication rates and length of stay (LOS) has made it an appealing tool for both patients and surgeons. However, the NSQIP Risk Calculator has been criticized for its generality and lack of detail towards surgical subspecialties, including the hepatopancreaticobiliary (HPB) surgery. We wish to determine whether the NSQIP Risk Calculator is predictive of post-operative complications and LOS with respect to Whipple's resections for our patient population...
May 2, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28454524/cost-effectiveness-of-ceftolozane-tazobactam-compared-with-piperacillin-tazobactam-as-empiric-therapy-based-on-the-in-vitro-surveillance-of-bacterial-isolates-in-the-united-states-for-the-treatment-of-complicated-urinary-tract-infections
#13
COMPARATIVE STUDY
Teresa L Kauf, Vimalanand S Prabhu, Goran Medic, Rebekah H Borse, Benjamin Miller, Jennifer Gaultney, Shuvayu S Sen, Anirban Basu
BACKGROUND: A challenge in the empiric treatment of complicated urinary tract infection (cUTI) is identifying the initial appropriate antibiotic therapy (IAAT), which is associated with reduced length of stay and mortality compared with initial inappropriate antibiotic therapy (IIAT). We evaluated the cost-effectiveness of ceftolozane/tazobactam compared with piperacillin/tazobactam (one of the standard of care antibiotics), for the treatment of hospitalized patients with cUTI. METHODS: A decision-analytic Monte Carlo simulation model was developed to compare the costs and effectiveness of empiric treatment with either ceftolozane/tazobactam or piperacillin/tazobactam in hospitalized adult patients with cUTI infected with Gram-negative pathogens in the US...
April 28, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28403585/the-role-of-nutraceuticals-and-phytotherapy-in-the-management-of-urinary-tract-infections-what-we-need-to-know
#14
Tommaso Cai, Irene Tamanini, Ekaterina Kulchavenya, Tamara Perepanova, Béla Köves, Florian M E Wagenlehner, Zafer Tandogdu, Gernot Bonkat, Riccardo Bartoletti, Truls E Bjerklund Johansen
Urinary Tract Infections (UTIs) are amongst the most common infectious diseases and carry a significant impact on patient quality of life and health care costs. Despite that, there is no well-established recommendation for a "standard" prophylactic antibiotic management to prevent UTI recurrences. The majority of patients undergoes long-term antibiotic treatment that severely impairs the normal microbiota and increases the risk of development of multidrugresistant microorganisms. In this scenario, the use of phytotherapy to both alleviate symptoms related to UTI and decrease the rate of symptomatic recurrences is an attractive alternative...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28396353/the-histidine-residue-of-qsec-is-required-for-canonical-signaling-between-qseb-and-pmrb-in-uropathogenic-escherichia-coli
#15
Erin J Breland, Ellisa W Zhang, Tomas Bermudez, Charles R Martinez, Maria Hadjifrangiskou
Two-component systems are prototypically comprised of a histidine kinase (sensor) and a response regulator (responder). The sensor kinases autophosphorylate at a conserved histidine residue, acting as a phosphodonor for subsequent phosphotransfer to and activation of a cognate response regulator. In rare cases, the histidine residue is also essential for response regulator dephosphorylation via a reverse-phosphotransfer reaction. In this work, we present an example of a kinase that relies on reverse phosphotransfer to catalyze the dephosphorylation of its cognate partner...
September 15, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28350901/gram-negative-bacterial-infections-research-priorities-accomplishments-and-future-directions-of-the-antibacterial-resistance-leadership-group
#16
Yohei Doi, Robert A Bonomo, David C Hooper, Keith S Kaye, James R Johnson, Cornelius J Clancy, Joshua T Thaden, Martin E Stryjewski, David van Duin
Antimicrobial resistance in pathogenic gram-negative bacteria is one of the most pressing challenges in the field of infectious diseases and is one of 4 key areas of unmet medical need identified by the Antibacterial Resistance Leadership Group (ARLG). The mission of the Gram-Negative Committee is to advance our knowledge of these challenging infections and implement studies to improve patient outcomes. Studies have fallen primarily into 2 broad categories: prospective cohort studies and interventional trials...
March 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28349603/ultrasound-is-an-effective-and-noninvasive-method-of-evaluating-renal-swelling-in-infants-with-their-first-urinary-tract-infection
#17
Y Simrén, E Stokland, K M Lagerstrand, S Valdimarsson, S Hansson
AIM: This study evaluated renal swelling in infants with a first urinary tract infection (UTI) by correlating renal length and volume with C-reactive protein (CRP) and body temperature. METHODS: Ultrasounds were carried out on 104 infants at The Queen Silvia Children's Hospital, Gothenburg, Sweden - 58 boys (mean age 3.3 months) and 46 girls (mean age 4.8 months) - during the acute phase of their UTI. A second scan was performed on 94 of them 4 weeks later. Renal length and volume were computed to standard deviation scores (SDS)...
March 27, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28328645/relationship-of-wound-ostomy-and-continence-certified-nurses-and-healthcare-acquired-conditions-in-acute-care-hospitals
#18
Diane K Boyle, Sandra Bergquist-Beringer, Emily Cramer
PURPOSE: The purpose of this study was to describe the (a) number and types of employed WOC certified nurses in acute care hospitals, (b) rates of hospital-acquired pressure injury (HAPI) and catheter-associated urinary tract infection (CAUTI), and (c) effectiveness of WOC certified nurses with respect to lowering HAPI and CAUTI occurrences. DESIGN: Retrospective analysis of data from National Database of Nursing Quality Indicators. SUBJECTS AND SETTINGS: The sample comprised 928 National Database of Nursing Quality Indicators (NDNQI) hospitals that participated in the 2012 NDNQI RN Survey (source of specialty certification data) and collected HAPI, CAUTI, and nurse staffing data during the years 2012 to 2013...
May 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28238602/a-new-way-to-prevent-urinary-tract-infections
#19
Florian M E Wagenlehner, Kurt G Naber
No abstract text is available yet for this article.
May 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28217698/questions-and-challenges-associated-with-studying-the-microbiome-of-the-urinary-tract
#20
REVIEW
Yige Bao, Kait F Al, Ryan M Chanyi, Samantha Whiteside, Malcom Dewar, Hassan Razvi, Gregor Reid, Jeremy P Burton
Urologists are typically faced with clinical situations for which the microbiome may have been a contributing factor. Clinicians have a good understanding regarding the role of bacteria related to issues such as antibiotic resistance; however, they generally have a limited grasp of how the microbiome may relate to urological issues. The largest part of the human microbiome is situated in the gastrointestinal tract, and though this is mostly separated from the urinary system, bacterial dissemination and metabolic output by this community is thought to have a significant influence on urological conditions...
January 2017: Annals of Translational Medicine
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