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https://www.readbyqxmd.com/read/29761047/a-survey-of-the-views-and-capabilities-of-community-pharmacists-in-western-australia-regarding-the-rescheduling-of-selected-oral-antibiotics-in-a-framework-of-pharmacist-prescribing
#1
Fatima Sinkala, Richard Parsons, Bruce Sunderland, Kreshnik Hoti, Petra Czarniak
Background: Antibiotic misuse in the community contributes to antimicrobial resistance. One way to address this may be by better utilizing community pharmacists' skills in antibiotic prescribing. The aims of this study were to examine the level of support for "down-scheduling" selected antibiotics and to evaluate factors determining the appropriateness of community pharmacist prescribing for a limited range of infections, including their decision to refer to a doctor. Methods: Self-administered questionnaires, including graded case vignette scenarios simulating real practice, were sent to Western Australian community pharmacists...
2018: PeerJ
https://www.readbyqxmd.com/read/29727865/prospective-study-on-several-urinary-biomarkers-as-indicators-of-renal-damage-in-children-with-cakut
#2
Fabio Bartoli, Valentina Pastore, Isabella Calè, Gabriella Aceto, Vittoria Campanella, Carla Lasalandra, Simona Magaldi, Francesco Niglio, Angela Basile, Raffaella Cocomazzi
PURPOSE:  The aim of the study was to investigate urinary levels of monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF), β-2-microglobulin (β2M), and FAS-ligand (FAS-L) in children with congenital anomalies of kidney and urinary tract (CAKUT) disease at risk of developing glomerular hyperfiltration syndrome. For this reason, we selected patients with multicystic kidney, renal agenesia and renal hypodysplasia, or underwent single nephrectomy. MATERIALS AND METHODS:  This prospective, multicentric study was conducted in collaboration between the Pediatric Surgery Unit in Foggia and the Pediatric Nephrology Unit in Bari, Italy...
May 4, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29680002/improving-the-utility-of-clinical-phenotyping-in-interstitial-cystitis-painful-bladder-syndrome-from-upoint-to-input
#3
Alice Crane, Jessica Lloyd, Daniel A Shoskes
INTRODUCTION: The phenotyping system UPOINT has proven effective in classifying patients with Urologic Pelvic Pain Syndromes in a clinically meaningful way and to guide therapy. While highly successful in men with chronic pelvic pain syndrome (CPPS), UPOINT is more limited in patients with interstitial cystitis/painful bladder syndrome (IC/PBS) since by definition all patients have the urinary and organ specific phenotype. Furthermore, AUA guidelines recommend a sequential tiered approach to therapy rather than the multimodal UPOINT scheme...
April 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29629891/ureterocele-fenestration-with-holmium-laser-in-neonates
#4
Predrag Ilic, Mirjana Jankovic, Maja Milickovic, Slobodan Dzambasanovic, Vladimir Kojovic
AIM: To evaluate the effectiveness of holmium-laser fenestration of intravesical ureteroceles in neonatal period. MATERIAL AND METHOD: We retrospectively analyzed the results of the holmium-laser puncture in ten neonates with intravesical ureterocele, between September 2013 and September 2016. Laser probe was placed through the cystoscope to the lowest and medial portion of the ureterocele, near the bladder floor. Few punctures (4 to 8) were made, until ureterocele has been collapsed...
2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29521882/catatonic-stupor-in-schizophrenic-disorders-and-subsequent-medical-complications-and-mortality
#5
Michitaka Funayama, Taketo Takata, Akihiro Koreki, Satoyuki Ogino, Masaru Mimura
OBJECTIVE: Although catatonia can occur secondary to a general medical condition, catatonia itself has been known to lead to various medical compolications. Although case reports on the association of catatonia with subsequent medical complications have been documented, no comprehensive large-scale study has been performed. To investigate specific medical complications after catatonia, we conducted a retrospective cohort study of specific medical complications of schizophrenia patients with catatonia...
May 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29417013/determinants-of-menstrual-hygiene-among-school-going-adolescent-girls-in-a-rural-area-of-west-bengal
#6
Ishita Sarkar, Madhumita Dobe, Aparajita Dasgupta, Rivu Basu, Bhaskar Shahbabu
Background: Menstrual hygiene is a neglected issue in rural India. Lack of menstrual hygiene in adolescent girls can make them susceptible to various morbidities, for example, reproductive tract infection and urinary tract infection and their long-term consequences, for example, cervical cancer, infertility, and ectopic pregnancy. This study aims to find out the determinants of menstrual hygiene among the school going adolescent girls in a rural area of West Bengal. Objectives: To elicit the menstrual hygiene practices among the study population and to find out the association of poor menstrual hygiene practices with sociodemographic factors, such as age, occupation and education of the parents, housing, and presence of sanitary toilet...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29410519/rationale-and-design-of-an-inhibitor-of-reca-protein-as-an-inhibitor-of-acinetobacter-baumannii
#7
Vishvanath Tiwari, Monalisa Tiwari, Deepika Biswas
Acinetobacter baumannii is one of the ESKAPE pathogen, which causes pneumonia, urinary tract infections, and is linked to high degree of morbidity and mortality. One-way antibiotic and disinfectant resistance is acquired by the activation of RecA-mediated DNA repair (SOS-response) that maintain ROS-dependent DNA damage caused by these anti-bacterial molecules. To increase the efficacy of different anti-microbial, there is a need to design an inhibitor against RecA of A. baumannii. We have performed homology modeling to generate the structure of RecA, followed by model refinement and validation...
May 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29402263/effect-of-the-2015-earthquake-on-pediatric-inpatient-pattern-at-a-tertiary-care-hospital-in-nepal
#8
Bishnu Rath Giri, Ram Hari Chapagain, Samana Sharma, Sandeep Shrestha, Sunita Ghimire, P Ravi Shankar
BACKGROUND: Earthquakes impact child health in many ways. Diseases occurring immediately following an earthquake have been studied in field based hospitals but studies on the inpatient disease pattern among children without trauma in a permanent hospital setup is lacking. METHODS: We examined the diagnoses of all children without trauma, admitted to Kanti Children's Hospital, Kathmandu for fifteen-week duration (from 4th week to end of the 18th week) following the 7...
February 5, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29395475/a-systematic-review-of-parents-experiences-and-information-needs-related-to-their-child-s-urinary-tract-infection
#9
REVIEW
Allison Gates, Jocelyn Shulhan, Robin Featherstone, Shannon D Scott, Lisa Hartling
OBJECTIVE: As a first step toward the development of an animated video and infographic to increase parents' knowledge of pediatric urinary tract infections (UTIs), we conducted a systematic review of their experiences and information needs. METHODS: We searched Ovid Medline, Ovid PsycINFO, CINAHL, and ProQuest Dissertations and Theses Global for studies published in 2000 or thereafter. We appraised quality using the Mixed Methods Appraisal Tool. We summarised the quantitative data narratively and the qualitative data thematically...
January 30, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29394218/urinary-management-with-an-external-female-collection-device
#10
Terrie Beeson, Carmen Davis
BACKGROUND: Strategies to decrease use of female indwelling urinary catheters and catheter-associated urinary tract infections are challenging due to the limited availability of proper fitting external collection devices. Female urinary incontinence predisposes the skin to potential pain, itching, burning, infection, or pressure injuries. CASE STUDIES: This article discusses 3 patients' trajectory of care with use of an external female urinary collection device...
March 2018: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/29356059/signs-and-symptoms-that-distinguish-detrusor-underactivity-from-mixed-detrusor-underactivity-and-bladder-outlet-obstruction-in-male-patients
#11
Andrew Gammie, Mathilde Kaper, Achim Steup, Satoshi Yoshida, Caroline Dorrepaal, Ton Kos, Paul Abrams
AIMS: This study aimed to identify signs and symptoms which show differences between men with detrusor underactivity (DU) compared to those with both DU and bladder outlet obstruction (BOO). METHODS: One thousand six hundred and twelve urodynamic tests on male patients were analyzed retrospectively. Signs and symptoms which showed a statistically significant difference between patients with DU alone and patients with both DU+BOO were identified. RESULTS: In the DU only group, considering only patients without a history of bladder outlet surgery, the number of daytime micturitions was lower, maximum voided volume on the bladder diary was higher, and slow stream was reported less often, whereas urinary tract infections were reported more often than for DU+BOO males...
January 22, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29281750/urine-dipstick-tests-can-aid-decision-making-when-treating-infants-with-unexplained-fever-but-more-research-is-needed
#12
Astha Panghal, Aakash Pandita, Girish Gupta, Kirti Naranje, Anita Singh
No abstract text is available yet for this article.
December 27, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29277046/the-effect-of-intravesical-instillations-with-hyaluronic-acid-on-sexual-dysfunction-in-women-with-recurrent-urinary-tract-infections-ruti
#13
Gemma Nightingale, Qasem Shehab, Chandrakumaran Kandiah, Lorraine Rush, Clare Rowe-Jones, Christian H Phillips
OBJECTIVE: To determine whether sexual dysfunction in women with recurrent urinary tract infections (RUTI) improved following treatment with intravesical Hyaluronic Acid (HA) instillations. STUDY DESIGN: Ethical approval was obtained for a prospective study to be performed. Patients referred for bladder instillations to treat RUTI, and who were sexually active, were recruited to the study. A selection of validated questionnaires (ICIQ-UI, ICIQ-VS, FSDS-R, ICIQ-FLUTS, O'Leary/Sant and PGI-I) were completed at baseline, three, six and 12 months after initiation of treatment with bladder instillations...
February 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29241659/a-novel-method-for-predicting-kidney-stone-type-using-ensemble-learning
#14
Yassaman Kazemi, Seyed Abolghasem Mirroshandel
The high morbidity rate associated with kidney stone disease, which is a silent killer, is one of the main concerns in healthcare systems all over the world. Advanced data mining techniques such as classification can help in the early prediction of this disease and reduce its incidence and associated costs. The objective of the present study is to derive a model for the early detection of the type of kidney stone and the most influential parameters with the aim of providing a decision-support system. Information was collected from 936 patients with nephrolithiasis at the kidney center of the Razi Hospital in Rasht from 2012 through 2016...
January 2018: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29224663/obstruction-of-the-biliary-and-urinary-system
#15
REVIEW
William O'Connell, Jay Shah, Jason Mitchell, J David Prologo, Louis Martin, Michael J Miller, Jonathan G Martin
Biliary and urinary obstructions can be managed endoscopically or cystoscopically, surgically or by percutansous intervention or drainage. If the obtructed system is infected, emergent decompression is needed. Early recognition and treatment is paramount in both conditions. Acute cholangitis can present many different ways, from mild symptoms to fulminant sepsis. It is usually a result of ascending bacterial colonization and biliary obstruction resulting in bacterial overgrowth. Therefore, those patients with recent biliary instrumentation or previous biliary modification are at higher risk...
December 2017: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/29221651/-the-myth-of-virgin-cleansing-latest-news-on-an-archaic-magico-religious-practice
#16
P Charlier, F Bou Abdallah, L Brun, V Hoang-Oppermann, S Deo, Y Mostefai-Dulac, M-F Mamzer, C Hervé
BACKGROUND: In the medical anthropology section of the Nanterre Hospital (France) for migrants and refugees, three cases were recorded of "virgin cleansing" in sub-Saharan African countries. PATIENTS AND METHODS: These consisted of sexual assaults (2 instances of rape and 1 of sexual interference) on sexually immature females (young girls) by patients with sexually transmitted infections (mainly HIV, syphilis) hoping they might thereby be cured. DISCUSSION: These particularly atrocious hetero-aggressive sexual practices based on magical arguments are unfortunately universal and are not limited to a specific culture...
December 5, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29215338/evaluation-of-antimicrobial-durability-and-anti-biofilm-effects-in-urinary-catheters-against-enterococcus-faecalis-clinical-isolates-and-reference-strains
#17
Didem Kart, Ayşe Semra Kustimur, Meral Sağıroğlu, Ayşe Kalkancı
BACKGROUND: Enterococcus faecalis, Escherichia coli, Staphylococcus epidermidis, Pseudomonas aeruginosa and Candida albicans biofilms are major causes of catheter-associated urinary tract infections. Antimicrobial-coated or impregnated urinary catheters are seen as a possible way to prevent these infections. AIMS: To determine the biofilm-forming ability of 89 E. faecalis isolates from urinary tract infections and to compare several urinary catheters for antimicrobial durability and the inhibitory effects on biofilm formation of different laboratory strains and clinical isolates of E...
December 1, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29194865/finasteride-accelerates-prostate-wound-healing-after-thulium-laser-resection-through-dht-and-ar-signalling
#18
Ruizhe Zhao, Xingjie Wang, Chenyi Jiang, Fei Shi, Yiping Zhu, Boyu Yang, Jian Zhuo, Yifeng Jing, Guangheng Luo, Shujie Xia, Bangmin Han
OBJECTIVES: Urinary tract infection, urinary frequency, urgency, urodynia and haemorrhage are common post-operative complications of thulium laser resection of the prostate (TmLRP). Our study mainly focuses on the role of finasteride in prostate wound healing through AR signalling. MATERIALS AND METHODS: TmLRP beagles were randomly distributed into different treatment groups. Serum and intra-prostatic testosterone and DHT level were determined. Histological analysis was conducted to study the re-epithelialization and inflammatory response of the prostatic urethra in each group...
November 30, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29177922/sglt1-and-sglt1-inhibitors-a-role-to-be-assessed-in-the-current-clinical-practice
#19
Leonardo Spatola, Silvia Finazzi, Claudio Angelini, Marco Dauriz, Salvatore Badalamenti
Diabetes is a complex disease of increasingly common occurrence worldwide. Attaining optimal glycemic control is the main challenge to prevent the development of diabetes-related complications and/or to stop their progression. In recent years, the pharmacologic toolkit for the treatment of diabetes has considerably expanded, thus paving the way to more pathophysiology-oriented therapies. For instance, the sodium-glucose cotransporters SGLT2 and SGLT1 have been in the spotlight because of better knowledge of their physiology and therapeutic potential...
February 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29075859/transabdominal-pre-peritoneal-versus-open-repair-for-primary-unilateral-inguinal-hernia-a-meta-analysis
#20
James J Wu, Joshua A Way, Guy D Eslick, Michael R Cox
BACKGROUND: Recent NICE guidelines recommend open surgical approaches for the treatment of primary unilateral inguinal hernias. However, many surgeons perform a laparoscopic approach based on the advantages of less post-operative pain and faster recovery. Our aim was to examine current evidence comparing transabdominal pre-peritoneal (TAPP) laparoscopic repair and open surgical repair for primary inguinal hernias. METHODS: A systematic search of six electronic databases was conducted for randomised controlled trials (RCTs) comparing TAPP and open repair for primary unilateral inguinal hernia...
May 2018: World Journal of Surgery
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