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https://www.readbyqxmd.com/read/29933552/pain-modulation-after-oromucosal-cannabinoid-spray-sativex-%C3%A2-in-patients-with-multiple-sclerosis-a-study-with-quantitative-sensory-testing-and-laser-evoked-potentials
#1
Mara Turri, Francesco Teatini, Francesco Donato, Giampietro Zanette, Valeria Tugnoli, Luciano Deotto, Bruno Bonetti, Giovanna Squintani
Background. Delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD) (nabiximols or Sativex® ) is an oromucosal spray formulation containing THC and CBD at an approximately 1:1 fixed ratio. Its administration for the treatment of pain in patients with multiple sclerosis (MS) has been established. MS patients generally complain of different kinds of pain, including spasticity-related and neuropathic pain. In this study, we compared and evaluated pain modulation and thermal/pain threshold of MS patients before and after THC/CBD administration...
June 21, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29933012/bioassay-guided-isolation-of-active-substances-from-semen-torreyae-identifies-two-new-anthelmintic-compounds-with-novel-mechanism-of-action
#2
Maoxuan Liu, Cedrick Veryser, Jing-Guang Lu, Tom Wenseleers, Wim M De Borggraeve, Zhi-Hong Jiang, Walter Luyten
ETHNOPHARMACOLOGICAL RELEVANCE: Semen Torreyae, the seeds of Torreya grandis Fortune ex Lindley (Cephalotaxaceae) is a well-known traditional Chinese medicinal plant recorded in the Chinese Pharmacopeia (2010 version). It is widely used for treating intestinal parasites in China, owing to its desirable efficacy and safety. However, the anthelmintic compounds in Semen Torreyae have not yet been identified. AIM OF THE STUDY: This study aims to identify the compounds active against helminths from Semen Torreyae...
June 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29928281/-immuno-transient-receptor-potential-ion-channels-the-role-in-monocyte-and-macrophage-mediated-inflammatory-responses
#3
REVIEW
Giorgio Santoni, Maria Beatrice Morelli, Consuelo Amantini, Matteo Santoni, Massimo Nabissi, Oliviero Marinelli, Angela Santoni
Monocytes and macrophages play important roles in health and disease. They have a central role in protecting the host, as they clear pathogens and modulate other immune cell functions through the production of regulatory molecules. Their functions include immune surveillance, bacterial killing, tissue remodeling and repair, clearance of cell debris and more. Macrophages can have beneficial and detrimental effects on the outcome of several diseases depending on the microenvironment and the activation state of cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29922176/transient-receptor-potential-vanilloid-1-expression-mediates-capsaicin-induced-cell-death
#4
Ricardo Ramírez-Barrantes, Claudio Córdova, Sebastian Gatica, Belén Rodriguez, Carlo Lozano, Ivanny Marchant, Cesar Echeverria, Felipe Simon, Pablo Olivero
The transient receptor potential (TRP) ion channel family consists of a broad variety of non-selective cation channels that integrate environmental physicochemical signals for dynamic homeostatic control. Involved in a variety of cellular physiological processes, TRP channels are fundamental to the control of the cell life cycle. TRP channels from the vanilloid (TRPV) family have been directly implicated in cell death. TRPV1 is activated by pain-inducing stimuli, including inflammatory endovanilloids and pungent exovanilloids, such as capsaicin (CAP)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29922125/key-genes-and-pathways-associated-with-inner-ear-malformation-in-sox10-p-r109w-mutation-pigs
#5
Qing-Qing Hao, Liang Li, Wei Chen, Qing-Qing Jiang, Fei Ji, Wei Sun, Hong Wei, Wei-Wei Guo, Shi-Ming Yang
SRY-box 10 (SOX10) mutation may lead to inner ear deformities. However, its molecular mechanisms on inner ear development are not clear. In this work, the inner ear morphology was investigated at different embryonic stages of the SOX10 mutation miniature porcine model with sensorineural hearing loss, and high-throughput RNA-seq and bioinformatics analyses were applied. Our results indicated that the SOX10 mutation in the miniature pigs led to an incomplete partition (IP) of the cochlea, a cystic apex caused by fusion from middle and apical turns, cochlear modiolar defects and a shortened cochlear duct...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29920663/solubility-and-subcellular-localization-of-the-three-drosophila-rdgc-phosphatase-variants-are-determined-by-acylation
#6
Lisa Strauch, Jens Pfannstiel, Armin Huber, Olaf Voolstra
Protein phosphorylation is an abundant molecular switch that regulates a multitude of cellular processes. In contrast to other subfamilies of phosphoprotein phosphatases, the PPEF subfamily is only poorly investigated. Drosophila retinal degeneration C (RDGC) constitutes the founding member of the PPEF subfamily. RDGC dephosphorylates the visual pigment rhodopsin and the ion channel TRP. rdgC null mutant flies exhibit rhodopsin and TRP hyperphosphorylation, altered photoreceptor physiology, and retinal degeneration...
June 19, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29914124/expression-profiling-of-the-transient-receptor-potential-vanilloid-trpv-channels-1-2-3-and-4-in-mucosal-epithelium-of-human-ulcerative-colitis
#7
Theodoros Rizopoulos, Helen Papadaki-Petrou, Martha Assimakopoulou
The Transient Receptor Potential (TRP) family of selective and non-selective ion channels is well represented throughout the mammalian gastrointestinal track. Several members of the Transient Receptor Potential Vanilloid (TRPV) subfamily have been identified in contributing to modulation of mobility, secretion and sensitivity of the human intestine. Previous studies have focused on the detection of TRPV mRNA levels in colon tissue of patients with inflammatory bowel disease (IBD) whereas little information exists regarding TRPV channel expression in the colonic epithelium...
June 15, 2018: Cells
https://www.readbyqxmd.com/read/29913874/activation-of-trpm8-cold-receptor-triggers-allodynia-like-behavior-in-spinally-injured-rats
#8
Tianle Gao, Jingxia Hao, Zsuzsanna Wiesenfeld-Hallin, Xiao-Jun Xu
Aims Pain in response to innocuous cold stimulation (cold allodynia) is a common symptom in patients with neuropathic pain. Cold allodynia is difficult to treat and its mechanisms are poorly understood. Several transient receptor potential (TRP) channels have been shown to be the molecular sensors for cold stimulation in a temperature-dependent manner, but the contribution of various TRP channels in mediating cold allodynia in neuropathic pain is unclear. We have previously shown that spinally injured rats developed neuropathic pain-like behaviors, including marked cold allodynia...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29906413/a-snap-25-cleaving-chimera-of-botulinum-neurotoxin-a-and-e-prevents-tnf%C3%AE-induced-elevation-of-the-activities-of-native-trp-channels-on-early-postnatal-rat-dorsal-root-ganglion-neurons
#9
Marc Nugent, Yamil R Yusef, Jianghui Meng, Jiafu Wang, J Oliver Dolly
Transient receptor potential (TRP) vallinoid 1 (TRPV1) and ankyrin 1 (TRPA1) are two transducing channels expressed on peripheral sensory nerves involved in pain sensation. Upregulation of their expression, stimulated by inflammatory cytokines and growth factors in animal pain models, correlate with the induction of nociceptive hyper-sensitivity. Herein, we firstly demonstrate by immuno-cytochemical labelling that TNFα augments the surface content of these channels on rat cultured dorsal root ganglion (DRG) neurons which, in turn, enhances the electrophysiological and functional responses of the latter to their specific agonists...
June 12, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29887879/a-proposed-molecular-mechanism-for-physical-analgesia-in-chronic-pain
#10
REVIEW
Norio Saito, Rei Shima, Yurika Yamada, Masaru Nagaoka, Etsuro Ito, Tohru Yoshioka
Although pain is indispensable for survival, chronic pain places a heavy burden on humans. As the efficacy of opioid treatment is limited, the development of alternative methods of pain relief without medication is desirable. Recently, we have developed a novel method of physical analgesia using an adhesive "pyramidal thorn patch." When we apply about 3 trials of these patches on the skin of a pain region, the pain region moves toward the spinal cord like a "cutaneous rabbit," and finally, the pain vanishes...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29883446/a-sensory-motor-neuron-type-mediates-proprioceptive-coordination-of-steering-in-c-elegans-via-two-trpc-channels
#11
Jihye Yeon, Jinmahn Kim, Do-Young Kim, Hyunmin Kim, Jungha Kim, Eun Jo Du, KyeongJin Kang, Hyun-Ho Lim, Daewon Moon, Kyuhyung Kim
Animal locomotion is mediated by a sensory system referred to as proprioception. Defects in the proprioceptive coordination of locomotion result in uncontrolled and inefficient movements. However, the molecular mechanisms underlying proprioception are not fully understood. Here, we identify two transient receptor potential cation (TRPC) channels, trp-1 and trp-2, as necessary and sufficient for proprioceptive responses in C. elegans head steering locomotion. Both channels are expressed in the SMDD neurons, which are required and sufficient for head bending, and mediate coordinated head steering by sensing mechanical stretches due to the contraction of head muscle and orchestrating dorsal head muscle contractions...
June 8, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29880642/critical-role-of-the-pore-domain-in-the-cold-response-of-trpm8-channels-identified-by-ortholog-functional-comparison
#12
María Pertusa, Bastián Rivera, Alejandro González, Gonzalo Ugarte, Rodolfo Madrid
In mammals, the main molecular entity involved in innocuous cold transduction is TRPM8.  This polymodal ion channel is activated by cold, cooling compounds such as menthol and voltage.  Despite its relevance, the molecular determinants involved in its activation by cold remain elusive.  In this study we explored the use of TRPM8 orthologs with different cold responses, as a strategy to identify new molecular determinants related with its thermosensitivity.  We focused on mouse TRPM8 (mTRPM8) and chicken TRPM8 (cTRPM8), which present complementary thermo- and chemo-sensitive phenotypes...
June 7, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29875336/trpm-family-channels-in-cancer
#13
REVIEW
Aline Hantute-Ghesquier, Aurélien Haustrate, Natalia Prevarskaya, V'yacheslav Lehen'kyi
Members of the TRPM ("Melastatin") family fall into the subclass of the TRP channels having varying permeability to Ca2+ and Mg2+ , with three members of the TRPM family being chanzymes, which contain C-terminal enzyme domains. The role of different TRPM members has been shown in various cancers such as prostate cancer for mostly TRPM8 and TRPM2, breast cancer for mostly TRPM2 and TRPM7, and pancreatic cancer for TRPM2/7/8 channels. The role of TRPM5 channels has been shown in lung cancer, TRPM1 in melanoma, and TRPM4 channel in prostate cancer as well...
June 7, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29871912/the-channel-kinase-trpm7-regulates-antigen-gathering-and-internalization-in-b-cells
#14
Mithunah Krishnamoorthy, Laabiah Wasim, Fathima Hifza Mohamed Buhari, Tiantian Zhao, Trisha Mahtani, Josephine Ho, Sohee Kang, Francina Deason-Towne, Anne-Laure Perraud, Carsten Schmitz, Bebhinn Treanor
Members of the transient receptor potential (TRP) family of ion channels are cellular sensors involved in numerous physiological and pathological processes. We identified the TRP subfamily M member 7 (TRPM7) channel-kinase as a previously uncharacterized regulator of B cell activation. We showed that TRPM7 played a critical role in the early events of B cell activation through both its ion channel and kinase functions. DT40 B cells deficient in TRPM7 or expressing a kinase-deficient mutant of TRPM7 showed defective gathering of antigen and prolonged B cell receptor (BCR) signaling...
June 5, 2018: Science Signaling
https://www.readbyqxmd.com/read/29871911/the-ion-channel-trpm7-is-required-for-b-cell-lymphopoiesis
#15
Mithunah Krishnamoorthy, Fathima Hifza Mohamed Buhari, Tiantian Zhao, Patrick M Brauer, Kyle Burrows, Eric Yixiao Cao, Vincent Moxley-Paquette, Arthur Mortha, Juan Carlos Zúñiga-Pflücker, Bebhinn Treanor
The transient receptor potential (TRP) family is a large family of widely expressed ion channels that regulate the intracellular concentration of ions and metals and respond to various chemical and physical stimuli. TRP subfamily M member 7 (TRPM7) is unusual in that it contains both an ion channel and a kinase domain. TRPM7 is a divalent cation channel with preference for Ca2+ and Mg2+ It is required for the survival of DT40 cells, a B cell line; however, deletion of TRPM7 in T cells does not impair their development...
June 5, 2018: Science Signaling
https://www.readbyqxmd.com/read/29869983/irreversible-temperature-gating-in-trpv1-sheds-light-on-channel-activation
#16
Ana Sánchez-Moreno, Eduardo Guevara-Hernández, Ricardo Contreras-Cervera, Gisela Rangel-Yescas, Ernesto Ladrón-de-Guevara, Tamara Rosenbaum, Leon D Islas
Temperature activated TRP channels or thermoTRPs are among the only proteins that can directly convert temperature changes into changes in channel open probability. In spite of a wealth of functional and structural information, the mechanism of temperature activation remains unknown. We have carefully characterized the repeated activation of TRPV1 by thermal stimuli and discovered a previously unknown inactivation process, which is irreversible. We propose that this form of gating in TRPV1 channels is a consequence of the heat absorption process that leads to channel opening...
June 5, 2018: ELife
https://www.readbyqxmd.com/read/29867539/revisiting-the-role-of-trp-orai-and-asic-channels-in-the-pulmonary-arterial-response-to-hypoxia
#17
REVIEW
Roberto V Reyes, Sebastián Castillo-Galán, Ismael Hernandez, Emilio A Herrera, Germán Ebensperger, Aníbal J Llanos
The pulmonary arteries are exquisitely responsive to oxygen changes. They rapidly and proportionally contract as arterial PO2 decrease, and they relax as arterial PO2 is re-established. The hypoxic pulmonary vasoconstriction (HPV) is intrinsic since it does not require neural or endocrine factors, as evidenced in isolated vessels. On the other hand, pulmonary arteries also respond to sustained hypoxia with structural and functional remodeling, involving growth of smooth muscle medial layer and later recruitment of adventitial fibroblasts, secreted mitogens from endothelium and changes in the response to vasoconstrictor and vasodilator stimuli...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29866033/functions-of-caphm7-in-the-regulation-of-ion-homeostasis-drug-tolerance-filamentation-and-virulence-in-candida-albicans
#18
Linghuo Jiang, Hongbo Pan
BACKGROUND: Calcium-permeable transient receptor potential (TRP) channels exist in eukaryotic cells from yeasts to animals and plants. and they act as sensors for various stresses. Arabidopsis thaliana calcium permeable stress-gated cation channel 1 (AtCSC1) was the first plant calcium-permeable TRP to be described and can be activated by hyperosmotic shock. Candida albicans CaPHM7 is one of the sequence homologs of AtCSC1, but its function remains unknown. RESULTS: We show here that CaPhm7 is localized to the plasma membrane in both the yeast and hyphal cells of C...
June 4, 2018: BMC Microbiology
https://www.readbyqxmd.com/read/29859451/interaction-of-anions-with-lipid-cubic-phase-membranes-an-electrochemical-impedance-study
#19
Mohammad Yaser Khani Meynaq, Britta Lindholm-Sethson, Solomon Tesfalidet
HYPOTHESIS: Electrochemical impedance spectroscopy is useful to monitor anionic interactions with a Lipid Cubic Phase, as previously demonstrated for cationic interaction (Khani Meynaq et al., 2016). It was expected that the smaller hydrophilic anions, acetate and chloride, would interact differently than the large tryptophan anion with its hydrophobic tail. EXPERIMENT: The impedance measurements enabled estimation of resistances and capacitances of a freestanding lipid cubic phase membrane at exposure to 4 and 40 mM solutions of NaCl, NaOAc and NaTrp...
May 29, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29847128/coupling-drosophila-melanogaster-cryptochrome-light-activation-and-oxidation-of-the-kv%C3%AE-subunit-hyperkinetic-nadph-cofactor
#20
Gongyi Hong, Ruth Pachter, Thorsten Ritz
Motivated by observations on the involvement of light-induced processes in the Drosophila melanogaster cryptochrome (DmCry) regulation of the neuronal firing rate, which is achieved by a redox state change of its voltage-dependent K+ channel Kvβ subunit Hyperkinetic (Hk) NADPH cofactor, we propose in this work two hypothetical pathways that potentially may enable such coupling. In the first pathway, triggered by blue-light-induced formation of a radical-pair [FAD•-TRP•+] in DmCry, the hole (TRP•+) may hop to Hk, e...
May 30, 2018: Journal of Physical Chemistry. B
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