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https://www.readbyqxmd.com/read/29658714/activation-of-trpv3-by-wood-smoke-particles-and-roles-in-pneumotoxicity
#1
Cassandra Deering-Rice, Nam Nguyen, Zhenyu Lu, James Cox, Darien Shapiro, Erin G Romero, Virginia K Mitchell, Katherine L Burrell, John M Veranth, Christopher A Reilly
Wood/biomass smoke particulate materials (WBSPM) are pneumotoxic, but mechanisms by which these materials affect lung cells are not fully understood. We previously identified transient receptor potential (TRP) ankyrin-1 as a sensor for electrophiles in WBSPM and hypothesized that other TRP channels expressed by lung cells might also be activated by WBSPM, contributing to pneumotoxicity. Screening TRP channel activation by WBSPM using calcium flux assays revealed TRPV3 activation by materials obtained from burning multiple types of wood under fixed conditions...
April 16, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29628598/transient-receptor-potential-channels-as-blood-biomarkers-for-pain-characteristics-in-patients-with-chronic-pain
#2
Norihiko Sukenaga, Munetaka Hirose
Transient receptor potential (TRP) channels play key roles for the transition from acute to chronic postoperative pain after surgery. To evaluate TRP channels in the peripheral blood cells as blood biomarkers for chronic pain, we collected blood samples for genome-wide assays of the mRNA expression and assessed pain intensity and the number of pain symptoms in 13 patients with chronic pain. There was a significant association between increases in the number of pain symptoms and increases in the TRP vanilloid 1 (TRPV1) expression...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29620434/transient-receptor-potential-polymorphism-and-haplotype-associate-with-crisis-pain-in-sickle-cell-disease
#3
Ellie H Jhun, Xiaoyu Hu, Nilanjana Sadhu, Yingwei Yao, Ying He, Diana J Wilkie, Robert E Molokie, Zaijie J Wang
AIM: Episodes of acute pain crisis contribute to considerable morbidity and mortality in sickle cell disease (SCD). Incomprehensive understanding of the underlying pain heterogeneity results in inadequate pain management. The transient receptor potential (TRP) family of voltage-gated ion channels acts as sensory transducers of diverse noxious stimuli. We performed an association study of polymorphisms in candidate genes TRPV1 and TRPA1 with pain in SCD patients. METHODS: Utilization rate, in other words, number of emergency department/acute care center admissions over 12 months as a result of pain crisis, served as a marker for acute pain...
April 5, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29617692/prognostic-significance-of-lncrna-pvt1-and-its-potential-target-gene-network-in-human-cancers-a-comprehensive-inquiry-based-upon-21-cancer-types-and-9972-cases
#4
Rong-Quan He, Mei-Jiao Qin, Peng Lin, Yi-Huan Luo, Jie Ma, Hong Yang, Xiao-Hua Hu, Gang Chen
BACKGROUND/AIMS: Whether the level of long noncoding RNA plasmacytoma variant translocation 1 gene (lncRNA PVT1) expression influences the clinical development and outcome of human cancers has not been thoroughly elucidated to date. Inconsistencies still exist regarding the associations between PVT1 and the clinicopathological features, including patient survival data. Additionally, the regulatory mechanism of PVT1 among human cancers remains unclear. METHODS: we conducted a comprehensive inquiry to verify the implication of PVT1 expression in cancer patients by conducting a meta-analysis of 19 selected studies and The Cancer Genome Atlas (TCGA) database to examine the relationship between PVT1 expression and both the prognosis and clinicopathological features of cancer patients using STATA 12...
March 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29616344/novel-pharmacological-nonopioid-therapies-in-chronic-pain
#5
REVIEW
Alan David Kaye, Elyse M Cornett, Brendon Hart, Shilpadevi Patil, Andrew Pham, Matthew Spalitta, Kenneth F Mancuso
PURPOSE OF REVIEW: Opioid use and abuse has led to a worldwide opioid epidemic. And while opioids are clinically useful when appropriately indicated, they are associated with a wide range of dangerous side effects and whether they are effective at treating or eliminating chronic pain is controversial. There has long been a need for the development of nonopioid alternative treatments for patients that live in pain, and until recently, only a few effective treatments were available. Today, there are a wide range of nonopioid treatments available including NSAIDs, acetaminophen, corticosteroids, nerve blocks, SSRIs, neurostimulators, and anticonvulsants...
April 3, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29616309/a-historical-perspective-on-the-role-of-sensory-nerves-in-neurogenic-inflammation
#6
REVIEW
João Sousa-Valente, Susan D Brain
The term 'neurogenic inflammation' is commonly used, especially with respect to the role of sensory nerves within inflammatory disease. However, despite over a century of research, we remain unclear about the role of these nerves in the vascular biology of inflammation, as compared with their interacting role in pain processing and of their potential for therapeutic manipulation. This chapter attempts to discuss the progress in understanding, from the initial discovery of sensory nerves until the present day...
April 3, 2018: Seminars in Immunopathology
https://www.readbyqxmd.com/read/29610016/trpv2-channel-inhibitors-attenuate-fibroblast-differentiation-and-contraction-mediated-by-keratinocyte-derived-tgf-%C3%AE-1-in-an-in-vitro-wound-healing-model-of-rats
#7
Taro Ishii, Kunitoshi Uchida, Shozaburo Hata, Mitsutoki Hatta, Tomo Kita, Yuki Miyake, Kazuhiko Okamura, Sachio Tamaoki, Hiroyuki Ishikawa, Jun Yamazaki
BACKGROUND: Keratinocytes release several factors that are involved in wound contracture and scar formation. We previously reported that a three-dimensional reconstruction model derived from rat skin represents a good wound healing model. OBJECTIVE: We characterized the role of transient receptor potential (TRP) channels in the release of transforming growth factor (TGF)-β1 from keratinocytes and the differentiation of fibroblasts to identify possible promising pharmacological approaches to prevent scar formation and contractures...
March 6, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29604058/mutations-in-the-voltage-sensing-domain-affect-the-alternative-ion-permeation-pathway-in-the-trpm3-channel
#8
Katharina Held, Fabian Gruss, Vincenzo Davide Aloi, Annelies Janssens, Chris Ulens, Thomas Voets, Joris Vriens
Transient receptor potential (TRP) channels are cationic channels involved in a broad array of functions, including homeostasis, motility and sensory functions. TRP channel subunits consist of six transmembrane segments (S1-S6), and form tetrameric channels with a central pore formed by the region encompassing S5 and S6. Recently, evidence was provided for the existence of an alternative ion permeation pathway in TRPM3, which allows large inward currents upon hyperpolarization independently from the central pore...
March 31, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29596157/machine-learned-analysis-of-the-association-of-next-generation-sequencing-based-human-trpv1-and-trpa1-genotypes-with-the-sensitivity-to-heat-stimuli-and-topically-applied-capsaicin
#9
Dario Kringel, Gerd Geisslinger, Eduard Resch, Bruno G Oertel, Michael C Thrun, Sarah Heinemann, Jörn Lötsch
Heat pain and its modulation by capsaicin varies among subjects in experimental and clinical settings. A plausible cause is a genetic component, of which TRPV1 ion channels, by their response to both heat and capsaicin, are primary candidates. However, TRPA1 channels can heterodimerize with TRPV1 channels and carry genetic variants reported to modulate heat pain sensitivity. To address the role of these candidate genes in capsaicin induced hypersensitization to heat, pain thresholds acquired before and after topical application of capsaicin and TRPA1/TRPV1 exomic sequences derived by next-generation sequencing were assessed in n = 75 healthy volunteers and the genetic information comprised 278 loci...
March 27, 2018: Pain
https://www.readbyqxmd.com/read/29589513/x-ray-crystallography-of-trp-channels
#10
Appu K Singh, Luke L McGoldrick, Kei Saotome, Alexander I Sobolevsky
Transient receptor potential (TRP) ion channels are molecular sensors of a large variety of stimuli including temperature, mechanical stress, voltage, small molecules including capsaicin and menthol, and lipids such as phosphatidylinositol 4,5-bisphosphate (PIP2 ). Since the same TRP channels may respond to different physical and chemical stimuli, they can serve as signal integrators. Many TRP channels are calcium permeable and contribute to Ca2+ homeostasis and signaling. Although the TRP channel family was discovered decades ago, only recently have the structures of many of these channels been solved, largely by cryo-electron microscopy (cryo-EM)...
March 28, 2018: Channels
https://www.readbyqxmd.com/read/29581825/novel-inhibitor-candidates-of-trpv2-prevent-damage-of-dystrophic-myocytes-and-ameliorate-against-dilated-cardiomyopathy-in-a-hamster-model
#11
Yuko Iwata, Yoshimi Katayama, Yasushi Okuno, Shigeo Wakabayashi
Transient receptor potential cation channel, subfamily V, member 2 (TRPV2) is a principal candidate for abnormal Ca2+ -entry pathways, which is a potential target for therapy of muscular dystrophy and cardiomyopathy. Here, an in silico drug screening and the following cell-based screening to measure the TRPV2 activation were carried out in HEK293 cells expressing TRPV2 using lead compounds (tranilast or SKF96365) and off-patent drug stocks. We identified 4 chemical compounds containing amino-benzoyl groups and 1 compound (lumin) containing an ethylquinolinium group as candidate TRPV2 inhibitors...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29578059/the-effect-of-the-electrophilic-fatty-acid-nitro-oleic-acid-on-trp-channel-function-in-sensory-neurons
#12
REVIEW
Jonathan M Beckel, William C de Groat
Nitro-oleic acid (NO2 -OA) and related nitroalkenes are electrophilic fatty acid derivatives that are present in normal tissues at nanomolar concentrations and can increase significantly during inflammation. These substances can suppress multiple intracellular signaling pathways contributing to inflammation by reversible Michael addition reactions with nucleophilic residues such as cysteine and histidine leading to post-translational modification of proteins. NO2 -OA also can influence inflammation and pain by acting on transient receptor potential (TRP) channels in primary sensory neurons...
March 22, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29577631/the-regulatory-mechanism-of-mammalian-trpmls-revealed-by-cryo-em
#13
REVIEW
Philip Schmiege, Michael Fine, Xiaochun Li
Transient receptor potential mucolipin (TRPML) channels are the most recently identified subfamily of TRP channels and have seen a surge of new reports revealing both structural and functional insight. In 2017, several groups published multiple conformations of TRPML channels using cryo-EM. Similar to other TRP channels, the ML subfamily consists of six transmembrane helices (S1-S6), and a pore region including S5, S6, and two pore helices (PH1 and PH2). However, these reports also reveal distinct structural characteristics of the ML subfamily...
March 26, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29574261/the-expression-of-trpv-channels-prostaglandin-e2-and-pro-inflammatory-cytokines-during-behavioural-fever-in-fish
#14
Sebastian Boltana, Nataly Sanhueza, Andrea Donoso, Andrea Aguilar, Diego Crespo, Daniela Vergara, Gabriel Arriagada, Byron Morales-Lange, Luis Mercado, Sonia Rey, Lluis Tort, Simon Mackenzie
A fever, or increased body temperature, is a symptom of inflammation, which is a complex defence reaction of the organism to pathogenic infections. After pathogens enter the body, immune cells secrete a number of agents, the functions of which stimulate the body to develop a functional immune and fever response. In mammals it is known that PGE2 is the principal mediator of fever. The extent to which PGE2 and other pro-inflammatory cytokines such as TNF-α, IL-6, or IL-1β could be involved in the induction of behavioural fever in fish remains to be clarified...
March 21, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29567962/cryo-em-structure-of-the-polycystic-kidney-disease-like-channel-pkd2l1
#15
Qiang Su, Feizhuo Hu, Yuxia Liu, Xiaofei Ge, Changlin Mei, Shengqiang Yu, Aiwen Shen, Qiang Zhou, Chuangye Yan, Jianlin Lei, Yanqing Zhang, Xiaodong Liu, Tingliang Wang
PKD2L1, also termed TRPP3 from the TRPP subfamily (polycystic TRP channels), is involved in the sour sensation and other pH-dependent processes. PKD2L1 is believed to be a nonselective cation channel that can be regulated by voltage, protons, and calcium. Despite its considerable importance, the molecular mechanisms underlying PKD2L1 regulations are largely unknown. Here, we determine the PKD2L1 atomic structure at 3.38 Å resolution by cryo-electron microscopy, whereby side chains of nearly all residues are assigned...
March 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29566267/tadalafil-attenuates-hypotonicity-induced-ca-2-influx-via-trpv2-and-trpv4-in-primary-rat-bladder-urothelial-cell-cultures
#16
Xiao Dong, Hiroshi Nakagomi, Tatsuya Miyamoto, Tatsuya Ihara, Satoru Kira, Norifumi Sawada, Takahiko Mitsui, Masayuki Takeda
AIMS: To investigate the localization of phosphodiesterase 5 (PDE5) and the molecular mechanism underlying the effect of the PDE5 inhibitor tadalafil in signal transduction in the bladder urothelium. METHODS: PDE5 expression in rat bladder tissues and cultured primary rat bladder urothelial cells was evaluated using immunochemistry and western blot assays. Ca2+ influx in cells exposed to isotonic solution, hypotonic solution, a selective transient receptor potential vanilloid 2 (TRPV2) channel agonist (cannabidiol), a selective TRPV4 channel agonist (GSK1016790A), a TRP cation channel melastatin 7 (TRPM7) channel agonist (PIP2), or a purinergic receptor agonist (ATP) in the presence or absence of 10 µM tadalafil was evaluated using calcium imaging techniques...
March 22, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29561829/the-role-of-endothelial-ca-2-signaling-in-neurovascular-coupling-a-view-from-the-lumen
#17
REVIEW
Germano Guerra, Angela Lucariello, Angelica Perna, Laura Botta, Antonio De Luca, Francesco Moccia
BACKGROUND: Neurovascular coupling (NVC) is the mechanism whereby an increase in neuronal activity (NA) leads to local elevation in cerebral blood flow (CBF) to match the metabolic requirements of firing neurons. Following synaptic activity, an increase in neuronal and/or astrocyte Ca2+ concentration leads to the synthesis of multiple vasoactive messengers. Curiously, the role of endothelial Ca2+ signaling in NVC has been rather neglected, although endothelial cells are known to control the vascular tone in a Ca2+ -dependent manner throughout peripheral vasculature...
March 21, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29557361/dyslipidemia-modulates-m%C3%A3-ller-glial-sensing-and-transduction-of-ambient-information
#18
REVIEW
Monika Lakk, Felix Vazquez-Chona, Oleg Yarishkin, David Križaj
Unesterified cholesterol controls the fluidity, permeability and electrical properties of eukaryotic cell membranes. Consequently, cholesterol levels in the retina and the brain are tightly regulated whereas depletion or oversupply caused by diet or heredity contribute to neurodegenerative diseases and vision loss. Astroglia play a central role in the biosynthesis, uptake and transport of cholesterol and also drive inflammatory signaling under hypercholesterolemic conditions associated with high-fat diet (diabetes) and neurodegenerative disease...
February 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29555902/predator-secreted-sulfolipids-induce-defensive-responses-in-c-elegans
#19
Zheng Liu, Maro J Kariya, Christopher D Chute, Amy K Pribadi, Sarah G Leinwand, Ada Tong, Kevin P Curran, Neelanjan Bose, Frank C Schroeder, Jagan Srinivasan, Sreekanth H Chalasani
Animals respond to predators by altering their behavior and physiological states, but the underlying signaling mechanisms are poorly understood. Using the interactions between Caenorhabditis elegans and its predator, Pristionchus pacificus, we show that neuronal perception by C. elegans of a predator-specific molecular signature induces instantaneous escape behavior and a prolonged reduction in oviposition. Chemical analysis revealed this predator-specific signature to consist of a class of sulfolipids, produced by a biochemical pathway required for developing predacious behavior and specifically induced by starvation...
March 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29552700/trpm2-and-warmth-sensation
#20
REVIEW
Chun-Hsiang Tan, Peter A McNaughton
The abilities to detect warmth and heat are critical for the survival of all animals, both in order to be able to identify suitable thermal environments for the many different activities essential for life and to avoid damage caused by extremes of temperature. Several ion channels belonging to the TRP family are activated by non-noxious warmth or by heat and are therefore plausible candidates for thermal detectors, but identifying those that actually regulate warmth and heat detection in intact animals has proven problematic...
March 19, 2018: Pflügers Archiv: European Journal of Physiology
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