Daniel M Makanyane, Sanam Maikoo, Fanie R Van Heerden, Lydia Rhyman, Ponnadurai Ramasami, Lindokuhle P Mabuza, Phikelelani Ngubane, Andile Khathi, Allen Mambanda, Irvin N Booysen
Our prior studies have illustrated that the uracil ruthenium(II) diimino complex, [Ru(H3 ucp)Cl(PPh3 )] (1) (H4 ucp = 2,6-bis-((6-amino-1,3-dimethyluracilimino)methylene)pyridine) displayed high hypoglycemic effects in diet-induced diabetic rats. To rationalize the anti-diabetic effects of 1, three new derivatives have been prepared, cis-[Ru(bpy)2 (urdp)]Cl2 (2) (urdp = 2,6-bis-((uracilimino)methylene)pyridine), trans-[RuCl2 (PPh3 )(urdp)] (3), and cis-[Ru(bpy)2 (H4 ucp)](PF6 )2 (4). Various physicochemical techniques were utilized to characterize the structures of the novel ruthenium compounds...
March 27, 2024: Journal of Inorganic Biochemistry