keyword
https://read.qxmd.com/read/38537154/the-future-of-liver-transplantation
#1
JOURNAL ARTICLE
Sandy Feng, Garrett R Roll, Foad J Rouhani, Alberto Sanchez Fueyo
Over the last 50 years, liver transplantation has evolved into a procedure routinely performed in many countries worldwide. Those able to access this therapy frequently experience a miraculous risk-benefit ratio since, particularly if they face imminently life threatening disease. Over the decades, the success of liver transplantation, with dramatic improvements in early post-transplant survival, has aggressively driven demand. However, in spite of the emergence of living donors to augment deceased donors as a source of organs, supply has lagged far behind demand...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537074/development-of-the-psu-child-pump
#2
JOURNAL ARTICLE
Christopher Scheib, Raymond Newswanger, Joshua Cysyk, Karl Bohnenberger, Branka Lukic, Lichong Xu, Eric Yeager, Kirby Bletcher, Patrick Leibich, Quandashia Jackson, Heidi Flory, Mindy Tillinger, William Weiss, Gerson Rosenberg, Choon-Sik Jhun
The Pennsylvania State University (PSU) Child Pump, a centrifugal continuous-flow ventricular assist device (cf-VAD), is being developed as a suitable long-term implantable device for pediatric heart failure patients between 10 and 35 kg, body surface area (BSA) of 0.5-1.2 m2, 1-11 years of age, and requiring a mean cardiac output of 1.0-3.5 L/min. In-vitro hydraulic and hemodynamic performances were evaluated on a custom mock circulatory loop with ovine blood. Normalized index of hemolysis (NIH) was evaluated under four conditions: 1) 8,300 rpm, 3...
March 28, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/38536795/why-do-people-sell-their-kidneys-a-thematic-synthesis-of-qualitative-evidence
#3
JOURNAL ARTICLE
Bijaya Shrestha, Luechai Sringernyuang, Manash Shrestha, Binita Shrestha, Anuska Adhikari, Dev Ram Sunuwar, Shiva Raj Mishra, Bipin Adhikari
Globally, demands for the kidneys have surpassed supply both living and deceased donors. High demands relative to the availability have made the kidney one of the most saleable human organs. The main objective was to explore the drivers of kidney selling. Literature related to kidney selling and its drivers was explored in three databases including MEDLINE (PubMed), Scopus (Elsevier), and JSTOR covering the period from 1987 to 2022. A total of 15 articles were selected, which underwent thematic analysis. Investigators independently assessed the articles for relevance and study quality to synthesize the data...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38536021/quality-measures-in-pre-liver-transplant-care-by-the-practice-metrics-committee-of-the-american-association-for-the-study-of-liver-diseases
#4
JOURNAL ARTICLE
Mayur Brahmania, Alexander Kuo, Elliot B Tapper, Michael Volk, Jennifer M Vittorio, Marwan Ghabril, Timothy Morgan, Fasiha Kanwal, Neehar D Parikh, Paul Martin, Shivang Mehta, Gerald S Winder, Gene Y Im, David Goldberg, Jennifer C Lai, Andres Duarte-Rojo, Angelo H Paredes, Arpan A Patel, Amandeep Sahota, Lisa M McElroy, Charlie Thomas, Anji E Wall, Maricar Malinis, Saima Aslam, Douglas A Simonetto, Nneka N Ufere, Sudha Ramakrishnan, Mary Margaret Flynn, Yasmin Ibrahim, Sumeet K Asrani, Marina Serper
INTRODUCTION: The LT evaluation and waitlisting process is subject to variations in care that can impede quality. The American Association for the Study of Liver Diseases (AASLD) Practice Metrics Committee (PMC) developed quality measures and patient-reported experience measures (PREMs) along the continuum of pre-LT care to reduce care variation and guide patient-centered care. METHODS: Following a systematic literature review, candidate pre-LT measures were grouped into four phases of care: referral, evaluation and waitlisting, waitlist management, and organ acceptance...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38535424/cardiorespiratory-performance-in-kidney-and-liver-transplant-recipients-the-dilemma-to-combine-lifestyle-and-fitness
#5
JOURNAL ARTICLE
Giovannino Polara, Alessio Montagnoli, Roberto Palazzo, Melissa Orlandi, Gabriele Mascherini, Marco Corsi, Edoardo Falconi, Laura Stefani
It is widely demonstrated that moderate-intensity exercise is associated with improved fitness in non-communicable chronic diseases. However, there are no specific guidelines available for transplant recipients. Body composition is closely linked to exercise capacity, typically estimated by cardiopulmonary testing, but its potential correlation with cardiovascular health outcomes has not been investigated yet. This study aims to evaluate and compare cardiorespiratory performance and body composition in two groups of liver and kidney transplant recipients...
February 29, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38533378/incidence-and-risk-factors-for-cancer-in-people-with-type-1-diabetes-stratified-by-stages-of-diabetic-kidney-disease-a-nationwide-finnish-cohort-study
#6
JOURNAL ARTICLE
Maija Feodoroff, Valma Harjutsalo, Sari Mäkimattila, Per-Henrik Groop
BACKGROUND: Individuals with type 1 diabetes (T1D) have been reported to have increased overall risk of cancer. In addition, individuals with a kidney transplant/transplantation (KT) have markedly increased cancer risk due to chronic use of immunosuppressive agents. However, it has not been elucidated whether the observed excess cancer risk is related to KT or whether diabetic kidney disease (DKD) per se is a risk factor for cancer in individuals with T1D. METHODS: The study included 5035 individuals from the Finnish Diabetic Nephropathy Study (FinnDiane) and 14,061 control individuals without diabetes...
May 2024: The Lancet regional health. Europe
https://read.qxmd.com/read/38533370/b-ultrasound-or-ct-guided-3d-printing-individualized-non-coplanar-template-brachytherapy-for-the-treatment-of-locally-uncontrolled-recurrent-head-and-neck-squamous-cell-carcinoma
#7
JOURNAL ARTICLE
Pengbing Han, Fengju Li, Yanping Zhang, Liying Gao, Guiqiong Zhang, Qing Guo, Yuxia Zhu, Qun Su
INTRODUCTION: It is worth to explore a more effective treatment method to minimize the damage for patients during the treatment process. AIM: To explore the method, feasibility and efficacy of B-ultrasound or computed tomography (CT)-guided 3D printing individualized non-coplanar template brachytherapy in the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma. MATERIAL AND METHODS: Ten patients with locally uncontrolled recurrent head and neck squamous cell carcinoma who were treated in our department from August 2021 to February 2023 were collected and treated by 3D printing individualized non-coplanar template brachytherapy under the guidance of B-ultrasound or CT, using the 192Ir high-dose rate afterloading treatment machine of NUCLETRON Technologies GmbH...
February 2024: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/38532708/rapid-life-saving-response-to-anti-pd-1-in-a-solid-organ-transplant-recipient-with-metastatic-cutaneous-squamous-cell-carcinoma-a-case-report-and-review
#8
JOURNAL ARTICLE
John P Antonelli, Myiah Quach, Aparna Mahajan, Jennifer Pleva, Vincent T Ma
Anti-programmed cell death protein 1 (PD-1) therapy is considered effective in the treatment of metastatic or locally advanced cutaneous squamous cell carcinoma but the use of these agents in solid organ transplant recipients (SOTRs) is often taken with caution. While anti-tumor effects without graft rejection have been reported, studies have shown high rates of fatal graft rejection with immune checkpoint therapy. In this case report, we present an SOTR patient with life-threatening, acute hypoxic respiratory failure due to rapidly progressive metastatic cutaneous squamous cell carcinoma with lung and pleural involvement...
March 27, 2024: Journal of Immunotherapy
https://read.qxmd.com/read/38532703/transplant-of-microbiota-from-crohn-s-disease-patients-to-germ-free-mice-results-in-colitis
#9
JOURNAL ARTICLE
Irshad Ali Sheikh, Jared Bianchi-Smak, Daniel Laubitz, Gabriele Schiro, Monica T Midura-Kiela, David G Besselsen, Gayatri Vedantam, Sara Jarmakiewicz, Rafał Filip, Fayez K Ghishan, Nan Gao, Pawel R Kiela
Although the role of the intestinal microbiota in the pathogenesis of inflammatory bowel disease (IBD) is beyond debate, attempts to verify the causative role of IBD-associated dysbiosis have been limited to reports of promoting the disease in genetically susceptible mice or in chemically induced colitis. We aimed to further test the host response to fecal microbiome transplantation (FMT) from Crohn's disease patients on mucosal homeostasis in ex-germ-free (xGF) mice. We characterized and transferred fecal microbiota from healthy patients and patients with defined Crohn's ileocolitis (CD_L3) to germ-free mice and analyzed the resulting microbial and mucosal homeostasis by 16S profiling, shotgun metagenomics, histology, immunofluorescence (IF) and RNAseq analysis...
2024: Gut Microbes
https://read.qxmd.com/read/38532680/-experience-of-providing-intensive-rehabilitation-care-to-a-school-aged-child-with-living-donor-lobar-lung-transplantation
#10
JOURNAL ARTICLE
Chiao-Ting Tsai, Fang-Yi Lin
The post-operative intensive care experience of a school-aged child who received living-donor bilateral lobar lung transplantation due to acute respiratory distress syndrome and interstitial pulmonary fibrosis is discussed in this paper. The patient received lungs donated by her parents in a "living-donor bilateral lobar lung transplantation" due to severe lung function impairment. The patient felt anxious due to her long-term hospitalization for preoperative evaluation, various invasive treatments, and postoperative rehabilitation...
April 2024: Hu Li za Zhi the Journal of Nursing
https://read.qxmd.com/read/38532630/restoration-of-t-and-b-cell-generation-in-x-linked-severe-combined-immunodeficiency-mice-through-adenine-base-editing-of-hematopoietic-stem-cells
#11
JOURNAL ARTICLE
Lu Zhang, Kai Li, Zhiwei Liu, Lisha An, Haikun Wei, Shanshan Pang, Zongfu Cao, Xingxu Huang, Xiaohua Jin, Xu Ma
Base editing of hematopoietic stem/progenitor cells (HSPCs) is an attractive strategy for treating immunohematologic diseases. However, the feasibility of using adenine base-edited HSPCs for treating X-linked severe combined immunodeficiency (SCID-X1), the influence of dose-response relationships on immune cell generation, and the potential risks have not been demonstrated in vivo. Here, a humanized SCID-X1 mouse model was established and 86.67% ± 2.52% (n = 3) of mouse hematopoietic stem cell (HSC) pathogenic mutations were corrected, with no sgRNA-dependent off-target effects detected...
March 26, 2024: Molecular Therapy
https://read.qxmd.com/read/38532458/a-phase-ii-study-of-belumosudil-for-chronic-graft-versus-host-disease-in-patients-who-failed-at-least-one-line-of-systemic-therapy-in-china
#12
JOURNAL ARTICLE
Ying Wang, Depei Wu, Xiang Zhang, Yuhua Li, Yanjie He, Qifa Liu, Li Xuan, Zhenyu Li, Kunming Qi, Yuqian Sun, Shunqing Wang, Wenjian Mo, Lei Gao, Ye Hua, Yu Wang, Ying Zhang
BACKGROUND: Chronic graft-versus-host disease (cGVHD) is an immune-related disorder that is the most common complication post-allogenic hematopoietic stem cell transplant. Corticosteroids with or without calcineurin inhibitors (CNIs) remain the mainstay of cGVHD treatment for first-line therapy. However, for many patients, cGVHD symptoms cannot be effectively managed and thus require second-line therapy. Currently, there is no approved treatment for second-line cGVHD treatment in China...
March 26, 2024: BMC Medicine
https://read.qxmd.com/read/38532336/pathfinder-chd-prospective-registry-on-adults-with-congenital-heart-disease-abnormal-ventricular-function-and-or-heart-failure-as-a-foundation-for-establishing-rehabilitative-prehabilitative-preventive-and-health-promoting-measures-rationale-aims-design-and
#13
JOURNAL ARTICLE
Sebastian Freilinger, Harald Kaemmerer, Robert D Pittrow, Stefan Achenbach, Stefan Baldus, Oliver Dewald, Peter Ewert, Annika Freiberger, Matthias Gorenflo, Frank Harig, Christopher Hohmann, Stefan Holdenrieder, Jürgen Hörer, Michael Huntgeburth, Michael Hübler, Niko Kohls, Frank Klawonn, Rainer Kozlik-Feldmann, Renate Kaulitz, Dirk Loßnitzer, Friedrich Mellert, Nicole Nagdyman, Johannes Nordmeyer, Benjamin A Pittrow, Leonard B Pittrow, Carsten Rickers, Stefan Rosenkranz, Jörg Schelling, Christoph Sinning, Mathieu N Suleiman, Yskert von Kodolitsch, Fabian von Scheidt, Ann-Sophie Kaemmerer-Suleiman
BACKGROUND: Adults with congenital heart defects (ACHD) globally constitute a notably medically underserved patient population. Despite therapeutic advancements, these individuals often confront substantial physical and psychosocial residua or sequelae, requiring specialized, integrative cardiological care throughout their lifespan. Heart failure (HF) is a critical challenge in this population, markedly impacting morbidity and mortality. AIMS: The primary aim of this study is to establish a comprehensive, prospective registry to enhance understanding and management of HF in ACHD...
March 26, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38532032/advances-and-applications-of-cancer-organoids-in-drug-screening-and-personalized-medicine
#14
REVIEW
Yujia Yang, Yajie Kong, Jinlei Cui, Yu Hou, Zhanjing Gu, Cuiqing Ma
In recent years, the rapid emergence of 3D organoid technology has garnered significant attention from researchers. These miniature models accurately replicate the structure and function of human tissues and organs, offering more physiologically relevant platforms for cancer research. These intricate 3D structures not only serve as promising models for studying human cancer, but also significantly contribute to the advancement of various potential applications in the field of cancer research. To date, organoids have been efficiently constructed from both normal and malignant tissues originating from patients...
March 27, 2024: Stem cell reviews and reports
https://read.qxmd.com/read/38531806/impact-of-the-kidney-allocation-revision-on-access-to-kidney-transplantation-and-outcomes-in-the-united-states
#15
JOURNAL ARTICLE
Oluwasegun A Akinyemi, Terhas A Weldeslase, Eunice A Odusanya, Kakra Hughes, Edward E Cornwell, Clive O Callender
BACKGROUND: The 2014 Kidney Allocation System (KAS) revision aimed to enhance equity in organ allocation and improve patient outcomes. This study assesses the impacts of the KAS revision on renal transplantation demographics and outcomes in the United States. METHODS: We conducted a retrospective study utilizing the Organ Procurement and Transplantation Network/Scientific Registry of Transplant Recipients (OPTN/SRTR) database from 1998 to 2022. We compared recipient and donor characteristics, and outcomes (graft failure and recipient survival) pre- and post-KAS revision...
March 26, 2024: American Surgeon
https://read.qxmd.com/read/38531684/kaposi-s-sarcoma-a-case-report
#16
JOURNAL ARTICLE
Ondřej Polách, Adam Kopecký, Zdeňka Wandrolová, Vladimír Židlík, Jan Němčanský
AIM: The aim of this case report is to present the case of a patient with iatrogenic Kaposi's sarcoma afflicting several organs, ocular manifestation. CASE REPORT: In a 74-year-old kidney transplant patient receiving immunosuppressive therapy, iatrogenic Kaposi's sarcoma (KS) developed in both lower eyelids. Subsequently, KS was confirmed in the region of the left forearm, with suspicion of lesions in the lungs. The ocular tumor was surgically removed with negative margins, requiring no further therapy...
2024: Ceská a Slovenská Oftalmologie
https://read.qxmd.com/read/38531429/validation-of-a-novel-donor-lung-scoring-system-based-on-the-updated-lung-composite-allocation-score-cas
#17
JOURNAL ARTICLE
Zhizhou Yang, Yun Zhu Bai, Yan Yan, Ramsey R Hachem, Chad A Witt, Rodrigo Vazquez Guillamet, Derek E Byers, Gary F Marklin, Daniel Kreisel, Ruben G Nava, Bryan F Meyers, Benjamin D Kozower, G Alexander Patterson, Matthew G Hartwig, Brendan T Heiden, Varun Puri
Lung transplantation continues to have lower rates of long-term graft survival compared to other organs. Additionally, lung utilization rates from brain-dead donors (BDDs) remain substantially lower compared to other solid organs, despite a growing need for lung transplantation and significant risk of waitlist mortality. This study aims to examine the effects of using a combination of the recently described novel lung donor acceptability score (LUNDON) and the newly adopted recipient lung composite allocation score (CAS) to guide transplantation...
March 24, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38531093/intraoperative-use-of-intra-aortic-balloon-pump-to-generate-pulsatile-flow-during-heart-transplantation-a-single-center-experience
#18
JOURNAL ARTICLE
Les James, Michael P Dorsey, Sumner E Kilmarx, Sallie Yassin, Shashwat Shrivastava, Neil Menghani, Vikram Bajaj, Eugene A Grossi, Aubrey C Galloway, Nader Moazami, Deane E Smith
The physiologic impact of pulsatile flow (PF) on end-organ perfusion during cardiopulmonary bypass (CPB) is controversial. Using an intra-aortic balloon pump (IABP) to maintain PF during CPB for patients undergoing heart transplantation (HT) may impact end-organ perfusion, with implications for postoperative outcomes. A single-center retrospective study of 76 patients bridged to HT with IABP was conducted between January 2018 and December 2022. Beginning in May 2022, patients received IABP-generated PF during CPB at an internal rate of 80 beats/minute...
March 27, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/38530691/contract-development-and-manufacturing-organization-selection-critical-considerations-that-can-make-or-break-your-cell-and-gene-therapy-development
#19
JOURNAL ARTICLE
Maryam A Pasdar, Mitchel M Sivilotti, Peter S Jaehn, Benham A Baghbaderani, John Lee, Bruce L Levine, William D Milligan
BACKGROUND AIMS: With the increase in cell and gene therapy (CGT) clinical trials in recent years has come a subsequent increase in the number of contract development and manufacturing organizations (CDMOs). Successful transition from development and early-phase clinical trials to commercialization of a CGT product often depends on selecting the best-suited CDMO. However, many CGT companies are small biotech companies that lack expertise in the field or do not have experience selecting and transferring a process to a CDMO...
March 11, 2024: Cytotherapy
https://read.qxmd.com/read/38530655/the-altruism-requirement-as-moral-fiction
#20
JOURNAL ARTICLE
Luke Semrau
It is widely agreed that living kidney donation is permitted but living kidney sales are not. Call this the Received View. One way to support the Received View is to appeal to a particular understanding of the conditions under which living kidney transplantation is permissible. It is often claimed that donors must act altruistically, without the expectation of payment and for the sake of another. Call this the Altruism Requirement. On the conventional interpretation, the Altruism Requirement is a moral fact...
March 26, 2024: Journal of Medicine and Philosophy
keyword
keyword
6731
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.