keyword
https://read.qxmd.com/read/37943081/cd304-adipose-tissue-derived-mesenchymal-stem-cell-abundance-in-autologous-fat-grafts-highly-correlates-with-improvement-of-localized-pain-syndromes
#21
JOURNAL ARTICLE
Tanja Rezzonico Jost, Alessia Lozito, Davide Mangani, Andrea Raimondi, Francesco Klinger, Diego Morone, Marco Klinger, Fabio Grassi, Valeriano Vinci
Surgery, burns or surgery-free accident are leading causes of scars with altered tissue consistency, a reduced degree of motion and pain. Autologous fat grafting can dramatically improve tissue consistency and elasticity but less frequently results in the reduction of pain. Therefore, we analyzed different cell populations present within the adipose tissue to be engrafted and correlated them with the reduction of pain after surgery. Here, we identify a population of CD3-CD4-CD304+ cells present in grafted adipose tissue, whose abundance highly correlates with pain improvement shortly after surgery (r2 = 0...
November 9, 2023: Pain
https://read.qxmd.com/read/37942750/the-value-of-whole-body-dual-energy-x-ray-absorptiometry-in-assessing-body-composition-in-patients-with-inflammatory-bowel-disease-a-prospective-study
#22
JOURNAL ARTICLE
Anke L Nguyen, Madhuni Herath, Megan Burns, Darcy Holt, Peter R Ebeling, Frances Milat, Peter R Gibson, Gregory T Moore
OBJECTIVES: Low skeletal muscle index (SMI) is common in inflammatory bowel disease (IBD) but has an uncertain relationship with active intestinal inflammation. This study evaluated body composition by whole-body dual-energy X-ray absorptiometry (DXA) in patients with IBD and healthy controls to enable the value of formal body composition analysis to be judged. METHODS: Patients with IBD and sex/age-matched controls prospectively underwent full body composition assessment by DXA, assessment by BMI, eating questionnaires and handgrip strength...
November 7, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37928271/roles-of-protein-post-translational-modifications-during-adipocyte-senescence
#23
REVIEW
Min-Seon Hwang, Jingyeong Park, Yunha Ham, In Hye Lee, Kyung-Hee Chun
Adipocytes are adipose tissues that supply energy to the body through lipids. The two main types of adipocytes comprise white adipocytes (WAT) that store energy, and brown adipocytes (BAT), which generate heat by burning stored fat (thermogenesis). Emerging evidence indicates that dysregulated adipocyte senescence may disrupt metabolic homeostasis, leading to various diseases and aging. Adipocytes undergo senescence via irreversible cell-cycle arrest in response to DNA damage, oxidative stress, telomere dysfunction, or adipocyte over-expansion upon chronic lipid accumulation...
2023: International Journal of Biological Sciences
https://read.qxmd.com/read/37927491/a-review-on-the-management-of-peripheral-neuropathic-pain-following-breast-cancer
#24
REVIEW
Francisco Avila, Ricardo Torres-Guzman, Karla Maita, John P Garcia, Gioacchino D De Sario, Sahar Borna, Olivia A Ho, Antonio J Forte
Postmastectomy pain syndrome (PMPS) is a common and debilitating form of postsurgical pain with neuropathic characteristics, presenting as burning, stabbing, or pulling sensations after mastectomy, lumpectomy, or other breast procedures. With a prevalence of 31%, the risk factors for PMPS include younger age, psychosocial factors, radiotherapy, axillary lymph node dissection, and a history of chronic pain. This review evaluates the pharmacological and surgical options for managing PMPS. Pharmacological treatment options include antidepressants, gabapentinoids, levetiracetam, capsaicin, and topical lidocaine...
2023: Breast Cancer: Targets and Therapy
https://read.qxmd.com/read/37918210/impact-of-bushfires-on-australian-livestock-health-welfare-and-carcase-quality
#25
JOURNAL ARTICLE
Aashima Auplish, Lachlan Ingram, Alexandra Green, Karren Plain, Brendan Cowled, Melanie Smith
The 2019/2020 Australian bushfires were unprecedented in terms of total area burned and impact on livestock and wildlife populations. However, there is currently limited literature available relating the consequences of bushfire or smoke exposure to livestock health, welfare, and carcase quality. A retrospective cross-sectional study was conducted using historical monitoring data from a Meat Standards Australia (MSA) accredited abattoir located on the mid-north coast of New South Wales, Australia. The spatiotemporal association between exposure to bushfire smoke (specifically the duration of the bushfires, distance from closest bushfire, annual bushfire season, proportion of the property of origin burned during the bushfires and time frame since exposure to bushfires) and effects on carcase meat quality metrics and pathology were measured, by building linear, generalised linear and cumulative link mixed models...
October 20, 2023: Preventive Veterinary Medicine
https://read.qxmd.com/read/37908940/epidemiology-types-causes-clinical-presentation-diagnosis-and-treatment-of-hypothyroidism
#26
REVIEW
Udit M Zamwar, Komal N Muneshwar
Hypothyroidism means an underactive thyroid gland. This leads to a decrease in the functioning of the thyroid gland. It is a very common endocrine disorder that causes under-secretion of thyroid hormones, mainly thyroxine (T4) and triiodothyronine (T3). It affects people of every age group but is more commonly found in women and older people. The symptoms of hypothyroidism can go unnoticed, may not be specific, and may overlap with other conditions, which makes it harder to diagnose it in some cases. Common symptoms include fatigue, weight gain, increased sensitivity to cold (cold intolerance), irregular bowel movements (constipation), and dry skin (xeroderma)...
September 2023: Curēus
https://read.qxmd.com/read/37908064/browning-of-white-adipose-tissue-may-be-an-appropriate-adaptive-response-to-critical-illness
#27
REVIEW
Stephen A McClave, Robert G Martindale
Both the baseline amount of brown adipose tissue (BAT) and the capacity to stimulate browning of white adipose tissue (WAT) may provide a protective effect to the patient in a critical care setting. Critical illness is associated with reduced mitochondrial volume and function resulting in increased production of reactive oxygen species, greater demand for adenosine triphosphate, a switch to uncoupled fat metabolism, and hibernation of the organelle which contribute to multiple organ failure. Increasing insulin resistance, decreasing fatty acid oxidation, and dependence on carbohydrate metabolism results...
October 31, 2023: JPEN. Journal of Parenteral and Enteral Nutrition
https://read.qxmd.com/read/37865959/ostarine-does-not-enhance-the-metabolic-effect-of-exercise-in-obese-rats
#28
JOURNAL ARTICLE
N Leciejewska, E Pruszynska-Oszmalek, M Sassek, M Głowacki, T Lehmenn, A Rekas-Dudziak, L Nogowski, K W Nowak, P A Kolodziejski
Overweight and obesity are associated with severe metabolic disorders and an increased risk of cardiovascular diseases. It is a known fact that physical activity has a positive effect on metabolic parameters, and also reduces the risk of diseases such as diabetes. Some products can enhance the rate of lipolysis and help in improving fat loss. One of these are selective androgen receptor modulators (SARMs) which act as anabolic agents and are also believed to aid in fat-burning. In this study, we investigated whether 30 days of ostarine administration could potentially improve metabolic parameters using the rat model of obesity combined with exercise...
August 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37862579/burning-fat-to-fuel-evs
#29
EDITORIAL
Clair Crewe, Jonathan R Brestoff
No abstract text is available yet for this article.
November 1, 2023: Diabetes
https://read.qxmd.com/read/37848615/effects-of-thermal-treatment-of-food-using-barbecue-fuels-on-ambient-air-and-beach-sands-within-recreation-facilities
#30
JOURNAL ARTICLE
Sebastian Kuś, Iwona Jelonek, Zbigniew Jelonek
Organised bathing areas located within leisure facilities, in addition to the function typical of their purpose, allow in most cases the use of their own barbecue facilities. This type of cooking of food before consumption is very popular during leisure time at the waterfront. However, cooking food on a barbecue produces fumes emitted from both the fuel being burned and the food being grilled. In addition, the fat from the grilled food falls on the hearth, contributing to the release of further toxic compounds and, in many cases, together with other exhaust fumes, causing considerable smoke and the summer smog effect...
October 17, 2023: Scientific Reports
https://read.qxmd.com/read/37841582/intestinal-microbial-circadian-rhythms-drive-sex-differences-in-host-immunity-and-metabolism
#31
JOURNAL ARTICLE
Sarah K Munyoki, Julie P Goff, Antonija Kolobaric, Armari Long, Steven J Mullett, Jennifer K Burns, Aaron K Jenkins, Lauren DePoy, Stacy G Wendell, Colleen A McClung, Kathleen E Morrison, Eldin Jašarević
Circadian rhythms dynamically regulate sex differences in metabolism and immunity, and circadian disruption increases the risk of metabolic disorders. We investigated the role of sex-specific intestinal microbial circadian rhythms in host metabolism using germ-free and conventionalized mice and manipulation of dietary-derived fat, fiber, and microbiota-accessible carbohydrates. Our findings demonstrate that sex differences in circadian rhythms of genes involved in immunity and metabolism depend on oscillations in microbiota, microbial metabolic functions, and microbial metabolites...
October 20, 2023: IScience
https://read.qxmd.com/read/37805767/-clinical-effect-of-the-giant-deep-inferior-epigastric-artery-paraumbilical-perforator-flap-in-repairing-the-circular-high-voltage-electric-burn-wounds-on-the-wrist
#32
JOURNAL ARTICLE
W L Du, Y M Shen, X H Hu, F J Qin, L Cheng
Objective: To investigate the clinical effect of the giant deep inferior epigastric artery paraumbilical perforator flap in repairing the circular high-voltage electric burn wounds on the wrist. Methods: A retrospective observational study method was used. From September 2016 to October 2021, thirteen male patients (aged 20-43 years) with annular high voltage (10-100 kV) electrical burns on the wrist were admitted to the Beijing Jishuitan Hospital. At the early stage after injury, the patient's wrist was subjected to incision, tension reduction and debridement, with the wound area after debridement being 27 cm×16 cm-32 cm×19 cm; in 12 patients with vascular injury, the radial or ulnar artery was reconstructed by great saphenous vein transplantation, with the length of 15-25 cm; the wrist wound was repaired by free transplantation of the deep inferior epigastric artery paraumbilical perforator flap (if the wound was giant, the lower abdominal flap carrying other perforators was used), with the area of 30 cm×19 cm-35 cm×20 cm...
June 20, 2023: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://read.qxmd.com/read/37805270/pulmonary-fat-embolism-after-cardiopulmonary-resuscitation
#33
JOURNAL ARTICLE
Lucia Ihnát Rudinská, Patricie Delongová, Jana Vaculová, Peter Ihnát
Pulmonary fat embolism (PFE) is usually observed in patients with long bone fractures, patients with extensive subcutaneous fat contusions or skin burns. Chest compressions during cardiopulmonary resuscitation (CPR) present powerful repetitive violence against victim's chest. Skeletal chest fractures are the most frequent complication of CPR, and probably the most important cause of PFE autopsy finding in persons, which have been resuscitated before death. The aim of the present paper was to investigate the prevalence and seriousness of PFE in non-survivors after out-of-hospital cardiac arrest...
2023: Soudní Lékarství
https://read.qxmd.com/read/37797204/sweet-swell-of-burning-fat-emerging-role-of-high-density-lipoprotein-in-energy-homeostasis
#34
JOURNAL ARTICLE
Anatol Kontush, Maximiliano Martin, Fernando Brites
PURPOSE OF REVIEW: Metabolism of lipids and lipoproteins, including high-density lipoprotein (HDL), plays a central role in energy homeostasis. Mechanisms underlying the relationship between energy homeostasis and HDL however remain poorly studied. RECENT FINDINGS: Available evidence reveals that HDL is implicated in energy homeostasis. Circulating high-density lipoprotein-cholesterol (HDL-C) levels are affected by energy production, raising with increasing resting metabolic rate...
October 6, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37796464/-clinical-case-report-of-acute-dinitrophenol-poisoning-with-a-fatal-outcome-of-udmurt-republic
#35
JOURNAL ARTICLE
I B Rudenko, D R Shaimardanova, R R Kayumova
Was to conduct the analysis of patient's clinical observation with acute dinitrophenol poisoning, admitted to a toxicological department of CCH №6 of Izhevsk, Udmurt Republic in 2021 yr. In this clinical case report, a 19 years old girl, who took 20 tablets of dinitrophenol, illegally obtained in online-shop, died. The fatal outcome was realized by the uncoupling of oxidative phosphorylation mechanism and cellular respiration, which in its turn led to serious dystrophic changes in all organs and tissues...
2023: Sudebno-meditsinskaia Ekspertiza
https://read.qxmd.com/read/37784147/use-of-coffee-husks-comparison-of-pellet-bedding-quality-performance-features-and-some-welfare-indicators-of-broiler-chickens
#36
JOURNAL ARTICLE
Jakub Biesek, Mirosław Banaszak, Sebastian Wlaźlak, Marek Adamski
BACKGROUND: The study aimed to evaluate the influence of wheat straw and different coffee husk (CHs) levels in pellet bedding on its quality, broiler chickens' performance, meat quality, and welfare indicators. In total, 200 Ross 308 chickens were divided into 4 groups: C - control with wheat straw pellet; CH10 - pellet with 10% CHs, CH25 - pellet with 25% CHs, and CH50 - pellet with 50% CHs. During 42 days of rearing, each bedding's physicochemical features were analyzed. The production results were controlled, and the footpad dermatitis, hock burns, and feather quality were assessed...
October 2, 2023: BMC Veterinary Research
https://read.qxmd.com/read/37779850/pharmacokinetic-relevance-of-glomerular-hyperfiltration-for-drug-dosing
#37
REVIEW
Carmine Zoccali, Francesca Mallamaci, Raffaele De Caterina
In chronic kidney disease (CKD) patients, hypofiltration may lead to the accumulation of drugs that are cleared mainly by the kidney and, vice versa, hyperfiltration may cause augmented renal excretion of the same drugs. In this review we mainly focus on the issue of whether hyperfiltration significantly impacts the renal clearance of drugs and whether the same alteration may demand an up-titration of the doses applied in clinical practice. About half of severely ill, septic patients and patients with burns show glomerular hyperfiltration and this may lead to enhanced removal of drugs such as hydrophilic antibiotics and a higher risk of antibiotic treatment failure...
October 2023: Clinical Kidney Journal
https://read.qxmd.com/read/37770323/use-of-autologous-adipose-tissue-in-acute-burn-wound-management-a-systematic-review
#38
JOURNAL ARTICLE
C Brenac, M Fieux, C Giroudon, N Gautherot Tournay, G Henry, H Person, C Ospital, A Mojallal
Fat transfer is increasingly used as part of our reconstructive armamentarium to address the challenges encountered in burn wounds and reconstructive surgery. The present systematic review aimed to evaluate the effectiveness of autologous fat transfer for acute burn wound management. A systematic review of the US National Library of Medicine, Cochrane Library, Web of Science, and Embase was conducted on October 15, 2022 (registration number CDR42022369726). A database watch was performed until submission of the manuscript...
September 26, 2023: Annales de Chirurgie Plastique et Esthétique
https://read.qxmd.com/read/37719178/cell-electrospinning-and-its-application-in-wound-healing-principles-techniques-and-prospects
#39
REVIEW
Zonghao Hu, Zishun Qin, Yue Qu, Feng Wang, Benheng Huang, Gaigai Chen, Xiaoyuan Liu, Lihua Yin
Currently, clinical strategies for the treatment of wounds are limited, especially in terms of achieving rapid wound healing. In recent years, based on the technique of electrospinning (ES), cell electrospinning (C-ES) has been developed to better repair related tissues or organs (such as skin, fat and muscle) by encapsulating living cells in a microfiber or nanofiber environment and constructing 3D living fiber scaffolds. Therefore, C-ES has promising prospects for promoting wound healing. In this article, C-ES technology and its advantages, the differences between C-ES and traditional ES, the parameters suitable for maintaining cytoactivity, and material selection and design issues are summarized...
2023: Burns and Trauma
https://read.qxmd.com/read/37705812/lipofilling-a-regenerative-alternate-for-remodeling-burn-scars-a-clinico-immunohistopathological-study
#40
JOURNAL ARTICLE
Bhojani Jatin, Durga Karki, Charanjeet Ahluwalia, Vamseedharan Muthukumar, Divyanjali Karki
Introduction  Any injury involving the dermis will lead to scarring. Scar tissue can cause functional limitations, cosmetic impairments, pain, and itch. Adipose-derived stem cells have also been shown to play a role in scar modulation. This study evaluates changes in lipofilled scar over the period of time and compares it with non-lipofilled scar tissue. Materials and Methods  A prospective case-control study with intraindividual follow-up was performed on 30 adult patients with post-burn scars from November 2016 to May 2019...
August 2023: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
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