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https://www.readbyqxmd.com/read/27920142/shedding-light-on-fat-dependence-in-aml
#1
(no author information available yet)
Scientists have begun unraveling the molecular intricacies that drive the appetite of acute myeloid leukemia for fat. They found that these tumor cells have particularly low levels of PHD3, an enzyme that normally activates ACC2 to repress fatty-acid oxidation. This fuels the cells' metabolic reliance on fat-burning, but also renders them highly susceptible to inhibitors of fatty-acid oxidation.
December 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27908624/a-review-of-biomass-burning-emissions-and-impacts-on-air-quality-health-and-climate-in-china
#2
REVIEW
Jianmin Chen, Chunlin Li, Zoran Ristovski, Andelija Milic, Yuantong Gu, Mohammad S Islam, Shuxiao Wang, Jiming Hao, Hefeng Zhang, Congrong He, Hai Guo, Hongbo Fu, Branka Miljevic, Lidia Morawska, Phong Thai, Yun Fat Lam, Gavin Pereira, Aijun Ding, Xin Huang, Umesh C Dumka
Biomass burning (BB) is a significant air pollution source, with global, regional and local impacts on air quality, public health and climate. Worldwide an extensive range of studies has been conducted on almost all the aspects of BB, including its specific types, on quantification of emissions and on assessing its various impacts. China is one of the countries where the significance of BB has been recognized, and a lot of research efforts devoted to investigate it, however, so far no systematic reviews were conducted to synthesize the information which has been emerging...
November 28, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27903627/the-role-of-the-antioxidant-system-during-intense-endurance-exercise-lessons-from-migrating-birds
#3
REVIEW
Clara Cooper-Mullin, Scott R McWilliams
During migration, birds substantially increase their metabolic rate and burn fats as fuel and yet somehow avoid succumbing to overwhelming oxidative damage. The physiological means by which vertebrates such as migrating birds can counteract an increased production of reactive species (RS) are rather limited: they can upregulate their endogenous antioxidant system and/or consume dietary antioxidants (prophylactically or therapeutically). Thus, birds can alter different components of their antioxidant system to respond to the demands of long-duration flights, but much remains to be discovered about the complexities of RS production and antioxidant protection throughout migration...
December 1, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27893580/the-effects-of-adipose-derived-stem-cell-differentiated-adipocytes-on-skin-burn-wound-healing-in-rats
#4
Yu-Wen Chen, Tabita Timeea Scutaru, Nicolae Ghetu, Eugen Carasevici, Cristian Dumitru Lupascu, Dan Ferariu, Dragos Pieptu, Corneliu-George Coman, Mihai Danciu
Both adipose-derived stem cells (ADSCs) and fat grafting promote burn wound healing, but whether adipogen-derived cells using various inducers such as 3-isobutyl-1-methylxanthine (IBMX) and insulin affect wound healing is unknown. Herein, ADSC-differentiated adipogenic lineages were used in rat burn wounds to evaluate wound healing potential. ADSCs were cultivated using six different adipogenic differentiation conditions (IBMX ± insulin, IBMX for 5 days, high and low Dulbecco's modified Eagle's medium) and in vitro morphological changes and cell proliferations during adipogenic differentiation were recorded...
November 11, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27886653/waffle-production-influence-of-baking-plate-material-on-sticking-of-waffles
#5
Regina Huber, Georg Kalss, Regine Schoenlechner
Background of this study was to understand the factors that contribute to sticking of fresh egg waffles on baking plates. The aim of this study was to investigate the sticking (adhesion) behavior of waffles on 4 different baking plate materials (ductile iron, grey iron, low alloyed steel, and steel with titanium nitrite coating) at different baking parameters (temperature and time) and application of 3 different release agents (different fat compositions). Baking plates from ductile and grey iron showed lower release properties of waffles than the 2 steel baking plates...
November 25, 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27881936/autologous-fat-transfer-to-the-subcutaneous-tissue-in-the-context-of-breast-reconstructive-procedures
#6
REVIEW
Pawel Szychta, Marek Zadrozny, Jan Rykala, Lukasz Banasiak, Henryk Witmanowski
Autologous fat transfer (AFT) is an appropriate technique for aesthetic rejuvenation of the face, aesthetic enhancement of hands, correction of the facial appearance in various disorders and constitutes a surgical alternative of treatment of numerous breast deformities ranging from distorting posttraumatic scars, post-eczema lesions, post-burn deformities to partial or total breast reconstruction. Our work is aimed to familiarize dermatologists with the technique of harvesting and implanting the aspirate of adipose cells in patients consulted for deformities of the breast...
October 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27804242/association-between-body-mass-index-percentile-trajectories-in-infancy-and-adiposity-in-childhood-and-early-adulthood
#7
Soyang Kwon, Kathleen F Janz, Elena M Letuchy, Trudy L Burns, Steven M Levy
OBJECTIVE: To identify distinct body mass index (BMI) percentile trajectories during early childhood and examine adiposity levels in childhood and early adulthood according to the BMI percentile trajectories. METHODS: Iowa Fluoride Study cohort parents (n = 1,093) reported their child's anthropometric data on average six times between ages 0 and 23 months. A subset of the cohort underwent DXA scans at approximately age 8 years (n = 495) and again at approximately age 19 years (n = 314)...
November 2, 2016: Obesity
https://www.readbyqxmd.com/read/27790049/hypermetabolic-conversion-of-plant-oil-into-water-endothermic-biochemical-process-stimulated-by-juvenile-hormone-in-the-european-firebug-pyrrhocoris-apterus-l
#8
Karel Sláma, Jan Lukáš
The physiological and biochemical mechanisms that enable insects to feed on dry food to secure enough water for larval growth were investigated. The study was carried out with a plethora of physiological methods, ranging from the simple volumetric determination of O2 consumption and water intake to more advanced methods such as scanning microrespirography and thermovision imaging of insect's body temperature. The experiments were done on the European firebug, Pyrrhocoris apterus, which feeds exclusively on dry linden seeds...
2016: International Journal of Insect Science
https://www.readbyqxmd.com/read/27784782/glucocorticoid-receptor-%C3%AE-induces-hepatic-steatosis-by-augmenting-inflammation-and-inhibition-of-the-peroxisome-proliferator-activated-receptor-ppar-%C3%AE
#9
Joseph S Marino, Lance A Stechschulte, David E Stec, Andrea Nestor-Kalinoski, Sydni Coleman, Terry D Hinds
Glucocorticoids (GCs) regulate energy supply in response to stress by increasing hepatic gluconeogenesis during fasting. Long-term GC treatment induces hepatic steatosis and weight gain. GC signaling is coordinated via the GC receptor (GR) GRα, as the GRβ isoform lacks a ligand-binding domain. The roles of the GR isoforms in the regulation of lipid accumulation is unknown. The purpose of this study was to determine whether GRβ inhibits the actions of GCs in the liver, or enhances hepatic lipid accumulation...
October 26, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27741445/polycyclic-aromatic-hydrocarbons-and-postmenopausal-breast-cancer-an-evaluation-of-effect-measure-modification-by-body-mass-index-and-weight-change
#10
Nicole Niehoff, Alexandra J White, Lauren E McCullough, Susan E Steck, Jan Beyea, Irina Mordukhovich, Jing Shen, Alfred I Neugut, Kathleen Conway, Regina M Santella, Marilie D Gammon
BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) have been linked to breast cancer in many, but not all, previous studies. PAHs are lipophilic and stored in fat tissue, which we hypothesized may result in constant low-dose exposure to these carcinogens. No previous studies have evaluated whether obesity modifies associations between multiple measures of PAHs and breast cancer incidence. METHODS: This population-based study included 1,006 postmenopausal women with first primary in situ or invasive breast cancer and 990 age-frequency matched controls...
January 2017: Environmental Research
https://www.readbyqxmd.com/read/27632398/effectiveness-of-autologous-fat-grafting-in-adherent-scars-results-obtained-by-a-comprehensive-scar-evaluation-protocol
#11
M E H Jaspers, K M Brouwer, A J M van Trier, M L Groot, E Middelkoop, P P M van Zuijlen
BACKGROUND: Nowadays, patients normally survive severe traumas such as burn injuries and necrotizing fasciitis. Large skin defects can be closed but the scars remain. Scars may become adherent to underlying structures when the subcutical fat layer is damaged. Autologous fat grafting (AFG) provides the possibility to reconstruct a functional sliding layer underneath the scar. AFG is becoming increasingly popular for scar treatment although large studies using validated evaluation tools are lacking...
September 14, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27622583/ucp1-protein-the-molecular-hub-of-adipose-organ-plasticity
#12
Saverio Cinti
In all mammals, adipocytes are cells with abundant cytoplasmic lipids forming the parenchyma of the adipose organ. White adipocytes store highly energetic molecules to release them, in the form of free fatty acids to survive between meals. Brown adipocytes trough their unique mitochondrial UCP1 protein burn glucose and lipids to perform thermogenesis in order to survive in cold environments. A third type of adipocytes appears in the subcutaneous depot of the adipose organ of female mice during pregnancy and lactation: the pink adipocytes...
September 10, 2016: Biochimie
https://www.readbyqxmd.com/read/27600980/antecedent-thermal-injury-worsens-split-thickness-skin-graft-quality-a-clinically-relevant-porcine-model-of-full-thickness-burn-excision-and-grafting
#13
Anders H Carlsson, Lloyd F Rose, John L Fletcher, Jesse C Wu, Kai P Leung, Rodney K Chan
Current standard of care for full-thickness burn is excision followed by autologous split-thickness skin graft placement. Skin grafts are also frequently used to cover surgical wounds not amenable to linear closure. While all grafts have potential to contract, clinical observation suggests that antecedent thermal injury worsens contraction and impairs functional and aesthetic outcomes. This study evaluates the impact of antecedent full-thickness burn on split-thickness skin graft scar outcomes and the potential mediating factors...
September 3, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/27570764/nutritional-cues-tie-living-organisms-to-their-environment-and-its-sustainability
#14
REVIEW
Melanie S Adams, Robert B Adams, Carol A Wessman, Barbara Demmig-Adams
We connect modern, intensive agriculture's role in environmental degradation to its role in producing nutritionally unbalanced foods, and delineate specific approaches to reduce agriculture's environmental impact, while producing healthful foods. We call attention to recently discovered genetic programs used by all living organisms to respond to their environment, and present a model of how these programs change body composition and function (of humans and their crop plants and livestock alike) in response to environmental cues...
2016: Frontiers in Nutrition
https://www.readbyqxmd.com/read/27556757/evidence-based-scar-management-how-to-improve-results-with-technique-and-technology
#15
Ibrahim Khansa, Bridget Harrison, Jeffrey E Janis
BACKGROUND: Scars represent the visible sequelae of trauma, injury, burn, or surgery. They may induce distress in the patient because of their aesthetically unpleasant appearance, especially if they are excessively raised, depressed, wide, or erythematous. They may also cause the patient symptoms of pain, tightness, and pruritus. Numerous products are marketed for scar prevention or improvement, but their efficacy is unclear. METHODS: A literature review of high-level studies analyzing methods to prevent or improve hypertrophic scars, keloids, and striae distensae was performed...
September 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27540151/metabolism-the-quest-to-burn-fat-effortlessly-and-safely
#16
COMMENT
Weiwei Fan, Ronald Evans
No abstract text is available yet for this article.
August 19, 2016: Science
https://www.readbyqxmd.com/read/27529154/fat-grafting-for-neuropathic-pain-after-severe-burns
#17
Luca Maione, Andrea Vittorio Emanuele Lisa, Valeriano Vinci, Francesco Klinger, Fabio Caviggioli, Marco Ettore Attilio Klinger
No abstract text is available yet for this article.
October 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27511471/oral-sensory-nerve-damage-causes-and-consequences
#18
REVIEW
Derek J Snyder, Linda M Bartoshuk
Oral sensations (i.e., taste, oral somatosensation, retronasal olfaction) are integrated into a composite sense of flavor, which guides dietary choices with long-term health impact. The nerves carrying this input are vulnerable to peripheral damage from multiple sources (e.g., otitis media, tonsillectomy, head injury), and this regional damage can boost sensations elsewhere in the mouth because of central interactions among nerve targets. Mutual inhibition governs this compensatory process, but individual differences lead to variation in whole-mouth outcomes: some individuals are unaffected, others experience severe loss, and some encounter sensory increases that may (if experienced early in life) elevate sweet-fat palatability and body mass...
June 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27505447/fat-grafting-for-neuropathic-pain-after-severe-burns-reply
#19
Charles Scott Hultman
No abstract text is available yet for this article.
October 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27464995/potential-of-taming-microrna-on-driver-seat-to-control-mitochondrial-horses-in-breast-carcinoma
#20
Shruti Purohit, Devashree Jahagirdar, Azad Kumar, Nilesh Kumar Sharma
Breast cancer among women is one of the most common carcinoma worldwide. In comparison to developed country, the breast cancer cases reported in India are boosted rapidly that in near future, statistically will surpass USA. At the same time, alarming statistics indicate that ratio of mortality cases over the total incidences is significantly high in comparison to developed world (Global Heath Estimates, WHO 2015). In recent times, several oncogenic signaling pathways have shown convergent effects on various types of cancer cell metabolism including breast cancer leading to tumor development...
July 27, 2016: MicroRNA
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