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fatal cases of chikungunya

Fernando Rosso, Robinson Pacheco, Sarita Rodríguez, Diego Bautista
The recent outbreaks of Chikungunya (CHIK-V) virus in endemic areas of dengue (DEN-V) could increase the risk of co-infection. CHIK infection has been considered not severe and with very unusual mortality, however DEN is associated with severe manifestations and increased mortality. Little is known about coinfection. It is possible that co-infection could generate severe cases. We present a case report of co-infection DEN-V -3 and CHIK-V in an elderly patient who developed acute renal failure, dengue shock syndrome (DSS), progresses to multiple organ failure and died...
August 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Jaime R Torres, Luiza H Falleiros-Arlant, Lourdes Dueñas, Jorge Pleitez-Navarrete, Doris M Salgado, José Brea-Del Castillo
BACKGROUND: During the years 2014 and 2015, the Region of the Americas underwent a devastating epidemic of chikungunya virus (CHIKV) of the Asian genotype, resulting in millions of affected individuals. However, epidemiological and clinical information on this experience is scarce. Prior knowledge of congenital and neonatal illness caused by CHIKV is limited and almost exclusively based on data obtained from a single outbreak of the East/Central/South African (ECSA) genotype. The effect of chikungunya fever (CHIKF) on pregnancy outcomes and its consequences for infants born to infected mothers at the peak of the epidemic wave in Latin America are reviewed herein...
September 13, 2016: International Journal of Infectious Diseases: IJID
Mauro Jorge Cabral-Castro, Regina Helena Saramago Peralta, Marta Guimarães Cavalcanti, Marzia Puccioni-Sohler, Valéria Lima Carvalho, Pedro Fernando da Costa Vasconcelos, José Mauro Peralta
Dengue is a mosquito-borne viral infection that can evolve from subclinical to severe forms of disease. Early recognition during initial primary and secondary infections correlates with a reduced case-fatality rate in susceptible groups. The aim of this study was to standardize a DNA hybridization assay based on the Luminex technology for detecting and serotyping dengue virus (DENV). Reference DENVs representing the four different serotypes were used as controls to standardize the test. For validation, 16 DENV isolates obtained from a reference laboratory were analyzed in a double-blind manner to validate the test...
October 2016: Journal of Virological Methods
Marcela Mercado, Jorge Acosta-Reyes, Edgar Parra, Lissethe Pardo, Angélica Rico, Alfonso Campo, Edgar Navarro, Diego Viasus
We report clinical features and histopathological findings in fatal cases with dengue (DENV) and chikungunya (CHIKV) co-infection identified at the Colombian National Institute of Health between September 2014 and October 2015. Seven such cases were documented. Dengue serotype 2 virus was identified in six cases. All patients were adults and comorbidities were present in four. Fever, arthralgia or myalgia was present in all cases. The frequency of rash, haemorrhage, oedema, and gastrointestinal symptoms was variable...
June 2, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Elaine O Nsoesie, Moritz Ug Kraemer, Nick Golding, David M Pigott, Oliver J Brady, Catherine L Moyes, Michael A Johansson, Peter W Gething, Raman Velayudhan, Kamran Khan, Simon I Hay, John S Brownstein
Chikungunya fever is an acute febrile illness caused by the chikungunya virus (CHIKV), which is transmitted to humans by Aedes mosquitoes. Although chikungunya fever is rarely fatal, patients can experience debilitating symptoms that last from months to years. Here we comprehensively assess the global distribution of chikungunya and produce high-resolution maps, using an established modelling framework that combines a comprehensive occurrence database with bespoke environmental correlates, including up-to-date Aedes distribution maps...
May 19, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Tara Perti, Cynthia A Lucero-Obusan, Patricia L Schirmer, Mark A Winters, Mark Holodniy
BACKGROUND: During December 2013, the first locally transmitted chikungunya virus (CHIKV) infections in the Americas were reported in the Caribbean. Although CHIKV infection is rarely fatal, risk for severe disease increases with age and medical comorbidities. Herein we describe characteristics of Veterans Health Administration (VHA) patients with CHIKV infection and, among those with infections diagnosed in Puerto Rico, investigated risk factors for hospitalization. METHODOLOGY: We queried VHA's national electronic medical records to identify patients with CHIKV testing during 2014...
May 2016: PLoS Neglected Tropical Diseases
Nina Méndez-Domínguez, Jorge Augusto Achach-Asaf, Luis Manuel Basso-García, Yazmín Berenice Quiñones-Pacheco, Salvador Gómez-Carro
INTRODUCTION: A chikungunya outbreak took place in the State of Yucatan starting in the second half of 2015 OBJECTIVE: To analyse the clinical course of a case of chikungunya in a previously healthy infant, providing practical evidence to guide future diagnoses and treatment during outbreak seasons in endemic areas CASE REPORT: Clinical manifestation started with a sudden onset of fever and a diffuse macular-papillary erythema, originally treated in the community with non-steroidal anti-inflammatory drugs...
March 2016: Revista Chilena de Pediatría
Patrick Gérardin, Thérèse Couderc, Marc Bintner, Patrice Tournebize, Michel Renouil, Jérome Lémant, Véronique Boisson, Gianandrea Borgherini, Frédérik Staikowsky, Frédéric Schramm, Marc Lecuit, Alain Michault
OBJECTIVE: To estimate the cumulative incidence rate (CIR) of Chikungunya virus (CHIKV)-associated CNS disease during the La Réunion outbreak, and assess the disease burden and patient outcome after 3 years. METHODS: CHIKV-associated CNS disease was characterized retrospectively in a cohort of patients with positive CHIKV reverse transcriptase PCR or anti-CHIKV immunoglobulin M antibodies in the CSF and fulfilling International Encephalitis Consortium criteria for encephalitis or encephalopathy...
January 5, 2016: Neurology
Wilmer Villamil-Gómez, Luz Alba-Silvera, Antonio Menco-Ramos, Alfonso Gonzalez-Vergara, Tatiana Molinares-Palacios, María Barrios-Corrales, Alfonso J Rodríguez-Morales
Congenital chikungunya virus (CHIK) infection has been infrequently reported, even more so during the current 2013-15 outbreak in Latin America. In this study, the consequences of CHIK on pregnancy outcomes and particularly consequences in infants born to infected women were assessed in a case series from a single private institution in the north of Colombia. During September 2014 to February 2015, seven pregnant women with serological and reverse transcription-polymerase chain reaction-positive test for CHIK delivered eight infants with CHIK...
October 2015: Journal of Tropical Pediatrics
Ivana B Hrnjaković Cvjetković, Dejan Cvjetković, Aleksandra Patić, Nataša Nikolić, Sandra Stefan Mikić, Vesna Milošević
INTRODUCTION: Chikungunya is a contagious disease caused by Chikungunya virus, an arbovirus from the Togaviridae family. This infection is mostly spread by mosquitoes from the genus Aedes, especially Aedes albopiclus, which have spread from Asia to America and Europe including some countries surrounding Serbia. EPIDEMIOLOGIC FEATURES: The outbreak of epidemics has been reported in Philippines, Sumatra, Java, Indonesia, West Africa region (from Senegal to Cameroon), Congo, Nigeria, Angola, Uganda, Guinea, Malawi, Central African Republic, Burundi, South Africa and India...
March 2015: Medicinski Pregled
Juan M de la Hoz, Brayan Bayona, Samir Viloria, José L Accini, Homero San Juan-Vergara, Diego Viasus
Although Chikungunya infection is emerging as an important public health problem in many countries, it is not regarded as a life-threatening disease. Information dealing with fatal cases is scarce. We herein describe three patients with Chickungunya infection who presented with multiple organ failure and died within 24h of admission. Two cases had positive anti-dengue IgM, but dengue coinfection was rejected based on the clinical features and results of real-time reverse transcription polymerase chain reaction...
August 2015: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Bharath Mudurangaplar, Basavaraj V Peerapur
BACKGROUND: Chikungunya is a debilitating, non-fatal, mosquito borne viral fever caused by Chikungunya virus (CHIVA). The disease is transmitted to humans by the bite of Aedes aegypti and Aedes albopictus mosquitoes. Severe outbreaks of Chikungunya have been reported in several countries of Africa and Asia. Chikungunya fever is characterized by fever with sudden onset, arthralgia, rash, headache and myalgia. However, arthralgia is painful and long-lasting, affecting primarily the peripheral joints...
May 2015: Journal of Clinical and Diagnostic Research: JCDR
Regina Ching Hua Lee, Justin Jang Hann Chu
Chikungunya virus (CHIKV) is the only causative agent of CHIKV fever with persistent arthralgia, and in some cases may lead to neurological complications which can be highly fatal, therefore it poses severe health issues in many parts of the world. CHIKV transmission can be mediated via the Aedes albopictus mosquito; however, very little is currently known about the involvement of mosquito cellular factors during CHIKV-infection within the mosquito cells. Unravelling the neglected aspects of mosquito proteome changes in CHIKV-infected mosquito cells may increase our understanding on the differences in the host factors between arthropod and mammalian cells for successful replication of CHIKV...
March 2015: PLoS Neglected Tropical Diseases
Yukti Sharma, Vandana Arya, Sanjay Jain, Manoj Kumar, Lopamudra Deka, Anjali Mathur
BACKGROUND: Concurrent infection with two agents can result in an illness having overlapping symptoms creating a diagnostic dilemma for the treating physician. The symptoms of dengue may mimic other diseases such as leptospirosis, influenza A, Salmonella Typhi, Japanese encephalitis, chikungunya and malaria. There is paucity of data regarding dengue and typhoid co- infection both in the developed and developing countries. This study attempts to find the current co- infection rates in North Delhi...
December 2014: Journal of Clinical and Diagnostic Research: JCDR
Matthew L Boisen, John S Schieffelin, Augustine Goba, Darin Oottamasathien, Abigail B Jones, Jeffrey G Shaffer, Kathryn M Hastie, Jessica N Hartnett, Mambu Momoh, Mohammed Fullah, Michael Gabiki, Sidiki Safa, Michelle Zandonatti, Marnie Fusco, Zach Bornholdt, Dafna Abelson, Stephen K Gire, Kristian G Andersen, Ridhi Tariyal, Mathew Stremlau, Robert W Cross, Joan B Geisbert, Kelly R Pitts, Thomas W Geisbert, Peter Kulakoski, Russell B Wilson, Lee Henderson, Pardis C Sabeti, Donald S Grant, Robert F Garry, Erica O Saphire, Luis M Branco, Sheik Humarr Khan
Lassa fever (LF) is a severe viral hemorrhagic fever caused by Lassa virus (LASV). The LF program at the Kenema Government Hospital (KGH) in Eastern Sierra Leone currently provides diagnostic services and clinical care for more than 500 suspected LF cases per year. Nearly two-thirds of suspected LF patients presenting to the LF Ward test negative for either LASV antigen or anti-LASV immunoglobulin M (IgM), and therefore are considered to have a non-Lassa febrile illness (NLFI). The NLFI patients in this study were generally severely ill, which accounts for their high case fatality rate of 36%...
February 2015: Viral Immunology
Haiyan Chu, Subash C Das, Jeremy F Fuchs, M Suresh, Scott C Weaver, Dan T Stinchcomb, Charalambos D Partidos, Jorge E Osorio
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, recently re-emerged in Africa and spread to islands in the Indian Ocean, the Indian subcontinent, and to South East Asia. Viremic travelers have also imported CHIKV to the Western hemisphere highlighting the importance of CHIKV in public health. In addition to the great burden of arthralgic disease, which can persist for months or years, epidemiologic studies have estimated case-fatality rates of ∼0.1%, principally from neurologic disease in older patients...
July 18, 2013: Vaccine
Mamidi Neeraja, Vemu Lakshmi, P K Dash, M M Parida, P V L Rao
INTRODUCTION: Dengue is an acute viral infection which presents as uneventful pyrexia to a fatal complication. This infection is increasingly being recognized as the world's major emerging tropical disease and an important public health problem. This article highlights the clinical manifestations of Dengue virus infection and the various molecular tests that were used for its laboratory diagnosis. METHODS: Serum samples from 713 suspected cases of Dengue were collected between August and December 2007...
March 2013: Journal of Clinical and Diagnostic Research: JCDR
(no author information available yet)
Chikungunya virus (CHIKV) is an alphavirus transmitted to humans through the bite of infected Aedes mosquitoes. CHIKV causes fever and usually is not fatal, but can cause debilitating joint pains or, in rare instances, severe illness. The East/Central/South African strain of chikungunya has been emerging in Asia since 2006, first in the Indian subcontinent, then Thailand. This report describes the characteristics of a local outbreak linked with chikungunya reemergence in a rural Asian setting. Sporadic cases of chikungunya were identified in Cambodia in 2011...
September 21, 2012: MMWR. Morbidity and Mortality Weekly Report
S Larrieu, E Balleydier, Ph Renault, M Baville, L Filleul
INTRODUCTION: The largest chikungunya epidemic in history hit Reunion Island in 2005/6. At that time, a specific monitoring system was set up. Since the end of the epidemic, this monitoring system has continued to operate and has been enhanced. The main objectives of the system are early detection of any case of chikungunya virus infection and epidemiological monitoring. METHODS: During nonepidemic periods, surveillance is focused on active detection of all cases...
March 2012: Médecine Tropicale: Revue du Corps de Santé Colonial
Bor Luen Tang
Chikungunya virus (CHIKV) infection causes a disease which appears to affect multiple cell types and tissues. The acute phase is manifested by a non-fatal febrile illness, polyarthralgia and maculopapular rashes in adults, but with recurrent arthralgia that may linger for months during convalescence. The issue of cellular and tissue tropism of CHIKV has elicited interest primarily because of this lingering incapacitating chronic joint pain, as well as clear encephalopathy in severe cases among neonates during the re-emergence of the virus in recent epidemics...
September 2012: Cellular Microbiology
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