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fatal cases of chikungunya

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https://www.readbyqxmd.com/read/29604514/renal-involvement-in-fatal-cases-of-chikungunya-virus-infection
#1
Marcela Mercado, Jorge Acosta-Reyes, Edgar Parra, Luis Guzmán, Mauricio Beltrán, Philippe Gasque, Carlos Mejía-García, Diego Viasus
BACKGROUND: Information regarding physiopathology and complications in fatal cases of chikungunya virus (CHIKV) is scarce. OBJECTIVES: The aim of this study was to describe the frequency and severity of renal complications in fatal cases associated with CHIKV infection based on the clinical and histopathological features from post-mortem tissue biopsies. STUDY DESIGN: This retrospective study included fatal cases associated with CHIKV infection occurring from September 2014 through October 2015, reported to National System for Public Health Surveillance (SIVIGILA) and laboratory-confirmed by the National Institute of Health of Colombia...
March 23, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29582731/vector-borne-disease-is-a-common-cause-of-hospitalized-febrile-illness-in-india
#2
Matthew L Robinson, Dileep Kadam, Sandhya Khadse, Usha Balasubramanian, Priyanka Raichur, Chhaya Valvi, Ivan Marbaniang, Savita Kanade, Jonathan Sachs, Anita Basavaraj, Renu Bharadwaj, Anju Kagal, Vandana Kulkarni, Jonathan Zenilman, George Nelson, Yukari C Manabe, Aarti Kinikar, Amita Gupta, Vidya Mave
Acute febrile illness (AFI) is a major cause of morbidity and mortality in India and other resource-limited settings, yet systematic etiologic characterization of AFI has been limited. We prospectively enrolled adults ( N = 970) and children (age 6 months to 12 years, N = 755) admitted with fever from the community to Sassoon General Hospital in Pune, India, from July 2013 to December 2015. We systematically performed a standardized clinical history, clinical laboratories, and diagnostics. Results from additional testing ordered by treating clinicians were also recorded...
March 26, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29160503/alert-severe-cases-and-deaths-associated-with-chikungunya-in-brazil
#3
REVIEW
Carlos Alexandre Antunes de Brito
Since the detection of the Chikungunya virus in America in 2013, two million cases of the disease have been notified worldwide. Severe cases and deaths related to Chikungunya have been reported in India and Reunion Island, estimated at 1 death per 1,000 inhabitants. Joint involvement in the acute and chronic phase is the main clinical manifestation associated with Chikungunya. The severity of the infection may be directly attributable to viral action or indirectly, owing to decompensation of preexisting comorbidities...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28722594/fatal-leptospira-spp-zika-virus-coinfection-puerto-rico-2016
#4
Paige Neaterour, Aidsa Rivera, Renee L Galloway, Myriam Garcia Negrón, Brenda Rivera-Garcia, Tyler M Sharp
Coinfection with pathogens that cause acute febrile illness (AFI) can complicate patient diagnosis and management. This report describes a fatal case of Leptospira spp./Zika virus (ZIKV) coinfection in Puerto Rico. The patient presented with a 5-day history of AFI; reported behavioral risk factors for leptospirosis; was diagnosed with possible leptospirosis, dengue, chikungunya, or ZIKV disease; and received appropriate treatment for leptospirosis and dengue. Following a 3-day hospitalization, the patient died due to acute gastrointestinal hemorrhage, and kidney and liver failure...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28577289/immunoglobulin-responsive-chikungunya-encephalitis-two-case-reports
#5
Stephanie Suzanne de O Scott, Pedro Braga-Neto, Lícia Pacheco Pereira, Paulo Ribeiro Nóbrega, Francisco de Assis Aquino Gondim, Manoel Alves Sobreira-Neto, Claudia Carvalho Mendes Schiavon
Chikungunya virus is an alphavirus transmitted by the mosquito Aedes, mainly Aedes aegypti and Aedes albopictus, that can cause acute illness, mostly self-limited, characterized by fever, maculopapular rash, and disabling polyarthritis/arthralgia, with an incubation period of 1 to 12 days. Chikungunya was largely regarded as a non-fatal and self-limited disease, but recently, serious cases have been reported including some with severe involvement of the nervous system, such as meningoencephalitis, myelitis, polyradiculitis, and polyradiculoneuropathy...
August 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28562768/chikungunya-virus-infection-with-severe-neurologic-manifestations-report-of-four-fatal-cases
#6
Priscilla Karen de Oliveira Sá, Michaela de Miranda Nunes, Ingrid Ramalho Leite, Maria das Graças Loureiro das Chagas Campelo, Cláudia Ferreira Ribeiro Leão, Joelma Rodrigues de Souza, Lúcio Roberto Castellano, Ana Isabel Vieira Fernandes
Here, we present four patients with confirmed Chikungunya virus infection showing atypical neurologic manifestations and death. This case series includes patients ranging in age from five to 92 years, with or without comorbidities. This report is important, as very few cases in the literature reporting death due to atypical Chikungunya virus infection are available.
March 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28499011/fatal-case-of-chikungunya-and-concomitant-thrombotic-thrombocytopenic-purpura-in-french-guiana-during-air-flight-medical-evacuation
#7
Loïc Epelboin, Bastien Bidaud, Emilie Mosnier, Paul Le Turnier, Guillaume Vesin, Gaëlle Walter, Philippe Abboud, Stéphanie Houcke, Maïa Forgues, Gérald Egmann, Alain Stepanian, Félix Djossou
Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy associated to severe ADAMTS13 deficiency. It has been linked to various viral infections. Among arboviruses, only Crimean-Congo haemorrhagic fever and dengue fever have been linked to this severe disease. We report the first documented case of TTP concomitant to Chikungunya virus infection.
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28444003/species-abundance-and-temporal-variation-of-arbovirus-vectors-in-brownsville-texas
#8
Krithika Srinivasan, Beatriz Tapia, Arturo Rodriguez, Robert Wood, Jennifer J Salinas
The recent outbreaks of the dengue fever and West Nile viruses and the looming threats of the Zika and chikungunya viruses highlight the importance of establishing effective, proactive arboviral surveillance in communities at high risk of transmission, such as those on the Texas-Mexico border. Currently, there are no approved human vaccines available for these mosquito-borne diseases, so entomological control and case management are the only known methods for decreasing disease incidence. The principal vectors, which include Culex quinquefasciatus, Aedes aegypti, and Ae...
April 20, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28424031/yellow-fever-from-angola-and-congo-a-storm-gathers
#9
REVIEW
Qanta A Ahmed, Ziad A Memish
In common with Zika, Chikungunya and Dengue, Yellow Fever (YF) is an arthropod-borne flavivirus. It is transmitted between humans and from monkeys by mosquitoes of the Aedes aegypti (its principal vector), haemogogus and albopictus varieties. Three cycles of transmission may occur: urban; sylvatic; and intermediate. Recently, sub-Saharan Africa has seen the resurgence of this neglected disease. The current YF outbreak in Angola began in December 2015 in the capital Luanda and by October 2016 there had been > 4300 suspected cases, with 376 deaths (case fatality rate = 8...
April 2017: Tropical Doctor
https://www.readbyqxmd.com/read/28393598/-zika-virus-infection-in-pregnancy
#10
Gabriella Varjasi, Róbert Póka
The Zika virus is a flavivirus spread by mosquitoes. Its primary vectors are the Aedes aegypti and the Aedes albopictus. Before 2007 it sporadically caused benign morbidity. Since 2015, it started spreading "explosively" in America, especially in Brazil. In August 2016 they reported cases from New York and Poland, too. Most of the infections don't produce any symptoms, but can cause grave complications. The most important lesion is microcephalia that forms in fetuses. Microcephalia's most serious consequence is mental retardation, which puts great burden on both the family and the society...
April 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28167590/chikungunya-and-neonatal-immunity-fatal-vertically-transmitted-chikungunya-infection
#11
Tracy Evans-Gilbert
AbstractChikungunya is a mosquito-borne infectious disease that has emerged as a global pathogen. The virus can pass vertically from mother to child especially during the perinatal period, with an intrapartum vertical transmission rate of 50%. Approximately half of the neonates infected with chikungunya present with severe symptoms and infrequently death. This report summarizes two severe cases of vertically transmitted neonatal chikungunya infection. One case was confirmed by real-time reverse transcription polymerase chain reaction and the other fulfilled clinical and epidemiological criteria...
April 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28097845/-fatal-case-of-rickettsiosis-in-a-toddler-from-southeastern-mexico
#12
César Lugo-Caballero, Karla Dzul-Rosado, Georgina Rodríguez-Moreno, Raúl Tello-Martín, Karina López-Ávila, Jorge Zavala-Castro
Rocky Mountain spotted fever is a disease caused by Rickettsia rickettsii, a bacteria transmitted by infected ticks. It is characterized by fever, exanthema, arthralgias and myalgias; but sometimes its clinical presentation is non specific. Due to its similarities with other exanthematic diseases like dengue or chikungunya, Rocky Mountain spotted fever is not a first line diagnosis, even though countries like Mexico show the ecologic and socioeconomic characteristics that favor its transmission, with a 30% mortality rate among pediatric patients...
February 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28069071/sporadic-cases-of-adult-measles-a-research-article
#13
Ranjan Premaratna, Nathasha Luke, Harsha Perera, Mahesh Gunathilake, Pubudu Amarasena, T G A Nilmini Chandrasena
BACKGROUND: Measles caused by a paramyxovirus, characterized by fever, malaise, cough, coryza conjunctivitis, a maculopapular rash is known to result in pneumonia, encephalitis and death. Fatal cases of measles in Sri Lanka are rare after implementation of the National Immunization Programme in 1984. Thereafter 0.1% case fatality rate was observed during October 1999-June 2000 which is a very low figure compared to other regional countries. Immunization guidelines were further revised in 2001, 2011 and in 2012 when additional immunization was recommended to age group 4-21 years; who are likely to have inadequate immunization, in order to achieve elimination of Measles by 2020...
January 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28054225/spectrum-and-burden-of-neglected-tropical-diseases-observed-in-an-infectious-and-tropical-diseases-unit-in-florence-italy-2000-2015
#14
Lorenzo Zammarchi, Iacopo Vellere, Leonardo Stella, Filippo Bartalesi, Marianne Strohmeyer, Alessandro Bartoloni
Neglected tropical diseases (NTDs) are a diverse group of acute and chronic conditions with distinct characteristics that thrive mainly among the poorest populations, almost exclusively in tropical countries. To evaluate the relevance and impact of NTDs in a temperate area, the number and features of patients diagnosed with NTDs at the Infectious and Tropical Diseases Unit (ITDU), Azienda Ospedaliero-Universitaria Careggi, Florence, Italy between 2000 and 2015 were retrospectively reviewed. Overall 289 NTD cases were diagnosed in 283 subjects accounting for 2...
June 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27920177/surveillance-for-chikungunya-and-dengue-during-the-first-year-of-chikungunya-virus-circulation-in-puerto-rico
#15
Tyler M Sharp, Kyle R Ryff, Luisa Alvarado, Wun-Ju Shieh, Sherif R Zaki, Harold S Margolis, Brenda Rivera-Garcia
After chikungunya virus (CHIKV) transmission was detected in Puerto Rico in May 2014, multiple surveillance systems were used to describe epidemiologic trends and CHIKV-associated disease. Of 28 327 cases reported via passive surveillance, 6472 were tested for evidence of CHIKV infection, and results for 4399 (68%) were positive. Of 250 participants in household cluster investigations, 70 (28%) had evidence of recent CHIKV infection. Enhanced surveillance for chikungunya at 2 hospitals identified 1566 patients who tested positive for CHIKV, of whom 10...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27920171/chikungunya-pathogenesis-from-the-clinics-to-the-bench
#16
Philippe Gasque, Marie Christine Jaffar Bandjee, Marcela Mercado Reyes, Diego Viasus
Chikungunya alphavirus has caused large epidemics worldwide and leads to acute incapacitating polyarthralgia. The inflammatory reaction over several days will drive robust innate and humoral responses essential to control the infection. Critically, fatal cases and mother-to-child transmission have also been described. Chikungunya can give rise to chronic musculoskeletal diseases, which can last for months to years, particularly in elderly individuals, and occasionally leads to seronegative rheumatoid arthritis-like pathologies...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27905632/-co-infection-by-chikungunya-virus-chik-v-and-dengue-virus-den-v-during-a-recent-outbreak-in-cali-colombia-report-of-a-fatal-case
#17
Fernando Rosso, Robinson Pacheco, Sarita Rodríguez, Diego Bautista
The recent outbreaks of Chikungunya (CHIK-V) virus in endemic areas of dengue (DEN-V) could increase the risk of co-infection. CHIK infection has been considered not severe and with very unusual mortality, however DEN is associated with severe manifestations and increased mortality. Little is known about coinfection. It is possible that co-infection could generate severe cases. We present a case report of co-infection DEN-V -3 and CHIK-V in an elderly patient who developed acute renal failure, dengue shock syndrome (DSS), progresses to multiple organ failure and died...
August 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/27619845/congenital-and-perinatal-complications-of-chikungunya-fever-a-latin-american-experience
#18
Jaime R Torres, Luiza H Falleiros-Arlant, Lourdes Dueñas, Jorge Pleitez-Navarrete, Doris M Salgado, José Brea-Del Castillo
BACKGROUND: During the years 2014 and 2015, the Region of the Americas underwent a devastating epidemic of chikungunya virus (CHIKV) of the Asian genotype, resulting in millions of affected individuals. However, epidemiological and clinical information on this experience is scarce. Prior knowledge of congenital and neonatal illness caused by CHIKV is limited and almost exclusively based on data obtained from a single outbreak of the East/Central/South African (ECSA) genotype. The effect of chikungunya fever (CHIKF) on pregnancy outcomes and its consequences for infants born to infected mothers at the peak of the epidemic wave in Latin America are reviewed herein...
October 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27393681/a-luminex-based-single-dna-fragment-amplification-assay-as-a-practical-tool-for-detecting-and-serotyping-dengue-virus
#19
Mauro Jorge Cabral-Castro, Regina Helena Saramago Peralta, Marta Guimarães Cavalcanti, Marzia Puccioni-Sohler, Valéria Lima Carvalho, Pedro Fernando da Costa Vasconcelos, José Mauro Peralta
Dengue is a mosquito-borne viral infection that can evolve from subclinical to severe forms of disease. Early recognition during initial primary and secondary infections correlates with a reduced case-fatality rate in susceptible groups. The aim of this study was to standardize a DNA hybridization assay based on the Luminex technology for detecting and serotyping dengue virus (DENV). Reference DENVs representing the four different serotypes were used as controls to standardize the test. For validation, 16 DENV isolates obtained from a reference laboratory were analyzed in a double-blind manner to validate the test...
October 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/27277216/clinical-and-histopathological-features-of-fatal-cases-with-dengue-and-chikungunya-virus-co-infection-in-colombia-2014-to-2015
#20
Marcela Mercado, Jorge Acosta-Reyes, Edgar Parra, Lissethe Pardo, Angélica Rico, Alfonso Campo, Edgar Navarro, Diego Viasus
We report clinical features and histopathological findings in fatal cases with dengue (DENV) and chikungunya (CHIKV) co-infection identified at the Colombian National Institute of Health between September 2014 and October 2015. Seven such cases were documented. Dengue serotype 2 virus was identified in six cases. All patients were adults and comorbidities were present in four. Fever, arthralgia or myalgia was present in all cases. The frequency of rash, haemorrhage, oedema, and gastrointestinal symptoms was variable...
June 2, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
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