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omeprazole and pregnancy

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https://www.readbyqxmd.com/read/27105398/a-young-woman-with-recurrent-gestational-hypercalcemia-and-acute-pancreatitis-caused-by-cyp24a1-deficiency
#1
Gina N Woods, Alec Saitman, Hanlin Gao, Nigel J Clarke, Robert L Fitzgerald, Nai-Wen Chi
The CYP24A1 gene encodes a mitochondrial 24-hydroxylase that inactivates 1,25(OH)2 D. Loss-of-function mutations in CYP24A1 cause hypercalcemia, nephrolithiasis and nephrocalcinosis. We describe a woman with CYP24A1 deficiency and recurrent gestational hypercalcemia. Her first pregnancy, at age 20, resulted with the intrauterine demise of twin fetuses. Postpartum, she developed severe hypercalcemia (14 mg/dL), altered mental status, and acute pancreatitis. Her PTH was suppressed (6 pg/mL) and her 1,25(OH)2 D was elevated (165 and 195 pg/mL on postpartum day 1 and 5, respectively)...
October 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/24374855/helicobacter-pylori-and-anemia-with-pregnancy
#2
Ehab H Nashaat, Ghada M Mansour
SUBJECTS AND METHODS: Study was conducted in Ain Shams University hospitals on 100 pregnant women with iron-deficiency anemia (IDA), including 50 cases infected with Helicobacter pylori (H. pylori) and 50 cases negative for H. pylori infection. Cases with symptomatic gastritis or hyperemesis gravidarum were not included in the study, obstetric history, sociodemographic and dietary variables were also assessed. Hemoglobin level, serum iron, serum ferritin, total iron binding capacity (TIBC), H...
June 2014: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/24215738/relaxant-effect-of-proton-pump-inhibitors-on-in-vitro-myometrium-from-pregnant-women
#3
C Terranova, C Petrella, G Improta, C Severini, F Signore, P Damiani, F Plotti, C Scarpignato, R Angioli
AIM: In this study we investigate in in vitro myometrial tissue samples of pregnant women: (a) the effects of proton pomp inhibitors (PPIs) (omeprazole, esomeprazole, pantoprazole, lansoprazole and rabeprazole) on spontaneous contractions; (b) the muscle-relaxant efficacy of the most active PPI considered (pantoprazole) in comparison with that of other known tocolytics (nifedipine, atosiban, MgSO4, isoxsuprine); (c) the effect of pantoprazole on contractions induced by calcium (Ca(++)), KCl, oxytocin and prostaglandin (PGE2); (d) the possible mediators of pantoprazole relaxant effect...
February 14, 2014: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/23662315/bismuth-metronidazole-tetracycline-why-risk-adding-bismuth
#4
COMPARATIVE STUDY
(no author information available yet)
The standard treatment for peptic ulcer associated with Helicobacter pylori is a combination of omeprazole, amoxicillin and clarithromycin, which renders the bacterium undetectable in about 70% of cases. A fixed-dose combination of bismuth subcitrate potassium + metronidazole + tetracycline has been authorised in some European countries for use in this setting, combined with high-dose omeprazole. In a European trial with 440 patients, the 4-drug combination of omeprazole + bismuth subcitrate + metronidazole + tetracycline was significantly more active than the standard 3-drug regimen in terms of H...
April 2013: Prescrire International
https://www.readbyqxmd.com/read/23333816/medications-as-a-potential-source-of-exposure-to-phthalates-among-women-of-childbearing-age
#5
Sonia Hernández-Díaz, Yung-Cheng Su, Allen A Mitchell, Katherine E Kelley, Antonia M Calafat, Russ Hauser
OBJECTIVE: To evaluate the association between the use of medications potentially containing phthalates and urinary concentrations of specific phthalate metabolites around conception. METHODS: Women enrolled in the Environment and Reproductive Health project from 2006 to 2009 completed questionnaires about the use of medications and provided multiple urine samples before and after conception. We compared the mean urinary concentration of phthalate metabolites between users of phthalate containing medications and a matched unexposed control group...
June 2013: Reproductive Toxicology
https://www.readbyqxmd.com/read/22314213/maternal-use-of-proton-pump-inhibitors-during-early-pregnancy-and-the-prevalence-of-hypospadias-in-male-offspring
#6
Rune Erichsen, Ellen Mikkelsen, Lars Pedersen, Henrik Toft Sørensen
Proton pump inhibitors (PPIs) are increasingly used in reflux disease treatment also among pregnant women. Hypospadias prevalence is increasing and the birth defect is diagnosed in 0.3%-0.8% of male births, but the association with maternal PPI use during pregnancy is virtually unknown. Therefore, we decided to estimate the hypospadias risk in male offspring after maternal PPI use during pregnancy. We used Danish nationwide registries to conduct a population-based prevalence study including all live-born boys from 1997 through 2009...
July 2014: American Journal of Therapeutics
https://www.readbyqxmd.com/read/22038541/the-safety-of-fetal-exposure-to-proton-pump-inhibitors-during-pregnancy
#7
I Matok, A Levy, A Wiznitzer, E Uziel, G Koren, R Gorodischer
BACKGROUND: Proton-pump inhibitors (PPIs) are often needed in pregnancy due to the high rates of acid reflux. Previous studies did not include medical pregnancy terminations data, which may cause a bias toward the null hypothesis. We assessed the fetal safety of PPIs following exposure during gestation including data from medical pregnancy terminations. METHODS: A unified computerized database was created by linking a computerized database of medications dispensed from 1998 to 2009 to all women registered in "Clalit" HMO, southern district of Israel, with computerized databases containing maternal and infant hospitalization records from the district hospital...
March 2012: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/21911976/effect-of-helicobacter-pylori-eradication-therapy-in-iron-deficiency-anaemia-of-pregnancy-a-pilot-study
#8
RANDOMIZED CONTROLLED TRIAL
Ria Malik, Kiran Guleria, Iqbal Kaur, Meera Sikka, Gita Radhakrishnan
BACKGROUND & OBJECTIVES: Despite routine iron supplementation and promotion of diet modification, iron deficiency anaemia (IDA) remains widely prevalent in our antenatal population. Recent studies in pediatric population have highlighted the role of Helicobacter pylori infection in IDA. This study was undertaken to study the effect of eradication therapy in H. pylori infected pregnant women with IDA. METHODS: Randomized placebo-controlled double blind clinical trial was done on 40 antenatal women between 14-30 wk gestation, with mild to moderate IDA and having H...
August 2011: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/21666223/aryl-hydrocarbon-receptor-and-aryl-hydrocarbon-nuclear-translocator-expression-in-human-and-rat-placentas-and-transcription-activity-in-human-trophoblast-cultures
#9
Lucie Stejskalova, Lenka Vecerova, Laura Mesa Peréz, Radim Vrzal, Zdenek Dvorak, Petr Nachtigal, Petr Pavek
Aryl hydrocarbon receptor (AHR) and its heterodimer aryl hydrocarbon nuclear translocator (ARNT) form a ligand-activated transcription complex that regulates expression of the AHR battery of target genes that includes the most important placental biotransformation enzyme cytochrome CYP1A1. Expression, placental localization, and ontogeny of AHR/Ahr and ARNT/Arnt have not been systematically studied in either human or rat placentas. Moreover, induction of such AHR target genes as CYP1A1, CYP1A2, CYP1B1, UGT1A1, and breast cancer resistance protein (BCRP), as well as of AHR, ARNT, and aryl hydrocarbon receptor repressor (AHRR) genes, after exposure to AHR ligands have not been studied in human placental trophoblast cultures...
September 2011: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/20414061/11-month-old-twins-with-food-avoidance
#10
Daniel B Kessler, Erin L Fortune, Ellen G Werner, Martin T Stein
Maggie and Lily are 11 month-old twins who are brought by their parents to the Developmental-Behavioral Pediatric Clinic for a life-long history of feeding difficulties. The twins are this couple's first children. Their mother is tearful as she recounts a stressful pregnancy complicated by pre-term labor beginning at 24 weeks gestation with strict bed rest for the remainder of the pregnancy. The twins were delivered at 35 weeks gestation by Caesarian Section. Lily weighed 5 lbs 11 oz; Maggie was small-for-gestational age with a birth weight of 3 lbs 13 oz...
April 2010: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/19491869/the-safety-of-proton-pump-inhibitors-ppis-in-pregnancy-a-meta-analysis
#11
REVIEW
Simerpal K Gill, Lisa O'Brien, Thomas R Einarson, Gideon Koren
OBJECTIVES: Heartburn and acid reflux are common medical disorders in pregnancy and can result in serious discomfort and complications. Furthermore, some pregnant women also experience more severe gastrointestinal conditions, such as Helicobacter pylori infections, peptic ulcers, and Zollinger-Ellison syndrome. To allow the use of proton pump inhibitors (PPIs) in pregnancy, the fetal safety of this drug class must be established. The aim of this study is to determine the fetal safety of PPIs during early pregnancy through systematic literature review...
June 2009: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/19270786/medications-as-a-potential-source-of-exposure-to-phthalates-in-the-u-s-population
#12
Sonia Hernández-Díaz, Allen A Mitchell, Katherine E Kelley, Antonia M Calafat, Russ Hauser
BACKGROUND: Widespread human exposure to phthalates, some of which are developmental and reproductive toxicants in experimental animals, raises concerns about potential human health risks. Underappreciated sources of exposure include phthalates in the polymers coating some oral medications. OBJECTIVE: The objective of this study was to evaluate whether users of phthalate-containing medications have higher urinary concentrations of phthalate metabolites than do nonusers...
February 2009: Environmental Health Perspectives
https://www.readbyqxmd.com/read/19004370/helicobacter-infection-decreases-reproductive-performance-of-il10-deficient-mice
#13
Julie M Sharp, Deborah A Vanderford, Maciej Chichlowski, Matthew H Myles, Laura P Hale
Infections with a variety of Helicobacter species have been documented in rodent research facilities, with variable effects on rodent health. Helicobacter typhlonius has been reported to cause enteric disease in immunodeficient and IL10(-/-) mice, whereas H. rodentium has only been reported to cause disease in immunodeficient mice coinfected with other Helicobacter species. The effect of Helicobacter infections on murine reproduction has not been well studied. The reproductive performance of C57BL/6 IL10(-/-) female mice intentionally infected with H...
October 2008: Comparative Medicine
https://www.readbyqxmd.com/read/18634247/-twenty-two-months-old-girl-with-haemorrhagic-gastritis-as-a-complication-after-the-nonsteroid-anti-inflammatory-drugs-application-case-report
#14
Grazyna Mierzwa, Marlena Jakubczyk, Monika Parzecka, Grazyna Swincow, Cezary Popławski
The aim of case report was to pay attention for possibility of side effects of nonsteroid anti-inflammatory drugs. Child of young and healthy parents was born after normal pregnancy, natural delivery. The disease started in two days before the admission, child had fever, cough and sneezing. Mother gave her two doses of ibuprofen. On the time of admission general state of patient was moderate; girl was apathic. In physical examination features of upper respiratory tract infection were shown. In the course of treatment antibiotic and symptomatic drugs including paracetamol (3x5 ml) were delivered...
January 2008: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/18265995/treating-common-problems-of-the-nose-and-throat-in-pregnancy-what-is-safe
#15
REVIEW
Petros V Vlastarakos, Leonidas Manolopoulos, Eleftherios Ferekidis, Aris Antsaklis, Thomas P Nikolopoulos
Although all kinds of medications should be avoided during pregnancy, the majority of pregnant women receive at least one drug and 6% of them during the high-risk period of the first trimester. The aim of the present paper is to discuss the appropriate management of rhinologic and laryngeal conditions that may be encountered during pregnancy. A literature review from Medline and database sources was carried out. Related books and written guidelines were also included. Controlled clinical trials, prospective and retrospective studies, case-control studies, laboratory studies, clinical and systematic reviews, metanalyses, and case reports were analysed...
May 2008: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/18034353/treating-common-ear-problems-in-pregnancy-what-is-safe
#16
REVIEW
Petros V Vlastarakos, Thomas P Nikolopoulos, Leonidas Manolopoulos, Eleftherios Ferekidis, George Kreatsas
In everyday practise, more than 80% of pregnant women receive one at least medication, often for ENT causes. The aim of the present paper is to review the literature on safety and administration of medical treatment for ear diseases, in pregnant women. The literature review includes Medline and database sources. Electronic links, related books and written guidelines were also included. The study selection was as follows: controlled clinical trials, prospective trials, case-control studies, laboratory studies, clinical reviews, systematic reviews, metanalyses, and case reports...
February 2008: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/17198667/-safety-of-proton-pump-inhibitors
#17
REVIEW
Juan V Esplugues, Miguel Martí-Cabrera, Julio Ponce
The significant inhibitory capacity of gastric acid secretion of PPIs makes them the drugs of choice for treating acid-related diseases. The considerable prevalence of these diseases and the need for maintaining the administration of the drug during considerably long periods results in this therapeutic group being one of the most widely used. However, in spite of their extensive use, there continue to emerge concerns about their potential toxicity; concerns surrounding the specificity of their mechanism of action and a consequential suspicion that something so potent must involve harmful effects...
November 25, 2006: Medicina Clínica
https://www.readbyqxmd.com/read/16893146/use-of-proton-pump-inhibitors-during-pregnancy-and-breastfeeding
#18
REVIEW
Alejandro A Nava-Ocampo, Elvia Y Velázquez-Armenta, Jung-Yeol Han, Gideon Koren
QUESTION: A 36-year-old pregnant patient has symptoms of peptic disease. Treatment with diet and lifestyle modifications and also antacids has given her little relief. If she were not pregnant, I would prescribe a proton pump inhibitor (PPI) for her. She is now 4 weeks pregnant, and I need to determine whether PPIs are safe during pregnancy. ANSWER: Data currently available suggest that omeprazole is not teratogenic in humans. While information on other PPIs is limited, a systematic review of the evidence suggests that they are also not teratogenic...
July 2006: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/16225482/review-article-the-management-of-heartburn-in-pregnancy
#19
REVIEW
J E Richter
Heartburn is a normal consequence of pregnancy. The predominant aetiology is a decrease in lower oesophageal sphincter pressure caused by female sex hormones, especially progesterone. Serious reflux complications during pregnancy are rare; hence upper endoscopy and other diagnostic tests are infrequently needed. Gastro-oesophageal reflux disease during pregnancy should be managed with a step-up algorithm beginning with lifestyle modifications and dietary changes. Antacids or sucralfate are considered the first-line drug therapy...
November 1, 2005: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/15691301/the-safety-of-proton-pump-inhibitors-in-pregnancy-a-multicentre-prospective-controlled-study
#20
MULTICENTER STUDY
O Diav-Citrin, J Arnon, S Shechtman, C Schaefer, M R van Tonningen, M Clementi, M De Santis, E Robert-Gnansia, E Valti, H Malm, A Ornoy
BACKGROUND: Proton pump inhibitors are used to treat gastro-oesophageal reflux and peptic ulcers. Gastro-oesophageal reflux is a common condition in pregnancy. Human pregnancy experience with lansoprazole or pantoprazole is very limited. More data exist on the safety of omeprazole in pregnancy. AIM: To assess the safety of proton pump inhibitors in pregnancy. METHODS: The rate of major anomalies was compared between pregnant women exposed to omeprazole, lanzoprazole, or pantoprazole and a control group counselled for non-teratogens...
February 1, 2005: Alimentary Pharmacology & Therapeutics
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