keyword
MENU ▼
Read by QxMD icon Read
search

microRNA IBD

keyword
https://www.readbyqxmd.com/read/27886173/integrative-epigenome-wide-analysis-demonstrates-that-dna-methylation-may-mediate-genetic-risk-in-inflammatory-bowel-disease
#1
N T Ventham, N A Kennedy, A T Adams, R Kalla, S Heath, K R O'Leary, H Drummond, D C Wilson, I G Gut, E R Nimmo, J Satsangi
Epigenetic alterations may provide important insights into gene-environment interaction in inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA methylation differences in 240 newly-diagnosed IBD cases and 190 controls. These include 439 differentially methylated positions (DMPs) and 5 differentially methylated regions (DMRs), which we study in detail using whole genome bisulphite sequencing. We replicate the top DMP (RPS6KA2) and DMRs (VMP1, ITGB2 and TXK) in an independent cohort. Using paired genetic and epigenetic data, we delineate methylation quantitative trait loci; VMP1/microRNA-21 methylation associates with two polymorphisms in linkage disequilibrium with a known IBD susceptibility variant...
November 25, 2016: Nature Communications
https://www.readbyqxmd.com/read/27855604/novel-microrna-signature-to-differentiate-ulcerative-colitis-from-crohn-disease-a-genome-wide-study-using-next-generation-sequencing
#2
Jingmei Lin, Xinjun Zhang, Zijin Zhao, Noah Welker, Yong Li, Yunlong Liu, Mary Bronner
BACKGROUND: The diagnosis of ulcerative colitis (UC) or Crohn disease (CD) can be challenging given the overlapping features. Knowledge of microRNAs in IBD has expanded recently and supports that microRNAs play an important role. This study aimed to identify novel microRNA biomarkers through comprehensive genome-wide sequencing to distinguish UC from CD. DESIGN: Illumina next generation sequencing was performed on nondysplastic fresh-frozen colonic mucosa of the distal-most colectomy from 19 patients (10 UC and 9 CD) and 18 patients with diverticular disease serving as controls...
November 17, 2016: MicroRNA
https://www.readbyqxmd.com/read/27853192/doxycycline-metronidazole-and-isotretinoin-do-they-modify-microrna-mrna-expression-profiles-and-function-in-murine-t-cells
#3
Eugenia Becker, Susan Bengs, Sirisha Aluri, Lennart Opitz, Kirstin Atrott, Claudia Stanzel, Pedro A Ruiz Castro, Gerhard Rogler, Isabelle Frey-Wagner
Inflammatory bowel disease (IBD) may develop due to an inflammatory response to commensal gut microbiota triggered by environmental factors in a genetically susceptible host. Isotretinoin (acne therapy) has been inconsistently associated with IBD onset and flares but prior treatment with antibiotics, also associated with IBD development, complicates the confirmation of this association. Here we studied in mice whether doxycycline, metronidazole or isotretinoin induce epigenetic modifications, and consequently change T-cell mRNA expression and/or function directly after treatment and after a 4 week recovery period...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27824649/downregulation-of-microrna-21-in-colonic-cd3-t-cells-in-uc-remission
#4
Yugo Ando, Luca Mazzurana, Marianne Forkel, Kazuichi Okazaki, Mamiko Aoi, Peter T Schmidt, Jenny Mjösberg, Francesca Bresso
BACKGROUND: In active inflammatory bowel disease (IBD), microRNA expression profiling consistently features disease-specific signatures, and microRNA-21 (miR-21) has been shown to be upregulated in the inflamed colon of patients with active ulcerative colitis (UC). However, the cellular sources of miR-21 expression in IBD tissues have not yet been identified. We sought to determine the expression levels of miR-21 and one of its downstream target genes, programmed cell death 4 (PDCD4), in CD3 T cells isolated from the colonic mucosa of patients with active IBD, inactive IBD, and non-IBD controls...
November 7, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27789943/rna-interference-based-nanosystems-for-inflammatory-bowel-disease-therapy
#5
REVIEW
Jian Guo, Xiaojing Jiang, Shuangying Gui
Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, is a chronic, recrudescent disease that invades the gastrointestinal tract, and it requires surgery or lifelong medicinal therapy. The conventional medicinal therapies for IBD, such as anti-inflammatories, glucocorticoids, and immunosuppressants, are limited because of their systemic adverse effects and toxicity during long-term treatment. RNA interference (RNAi) precisely regulates susceptibility genes to decrease the expression of proinflammatory cytokines related to IBD, which effectively alleviates IBD progression and promotes intestinal mucosa recovery...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27729225/microrna-mediated-network-motifs-in-autoimmune-diseases-and-its-crosstalk-between-genes-functions-and-pathways
#6
Archana Prabahar, Jeyakumar Natarajan
Autoimmune diseases (AIDs) are incurable but suppressible diseases whose molecular mechanisms are yet to be elucidated. In this work, we selected five systemic autoimmune diseases such as Rheumatoid Arthritis (RA), Type 1 Diabetes (T1D), Inflammatory Bowel Disease (IBD), Autoimmune Thyroid Disease (ATD) and Systemic Lupus Erythematosus (SLE) and integrated their heterogeneous data such as miRNA, transcription factor (TF), target genes and protein-protein interactions involved in these AIDs to understand their roles at different functional levels of miRNA such as transcription initiation, gene regulatory network formation and post transcriptional regulation...
October 8, 2016: Journal of Immunological Methods
https://www.readbyqxmd.com/read/27718165/polymorphisms-in-mir122-mir196a2-and-mir124a-genes-are-associated-with-clinical-phenotypes-in-inflammatory-bowel-diseases
#7
Cinzia Ciccacci, Cristina Politi, Livia Biancone, Andrea Latini, Giuseppe Novelli, Emma Calabrese, Paola Borgiani
BACKGROUND: Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC), are multifactorial disorders that result from a dysregulated inflammatory response to environmental factors in genetically predisposed individuals. Recently, microRNAs (miRNAs) have been shown to be involved in the development of IBDs. AIMS: We investigated common variants in five miRNA genes in a cohort of Italian IBD patients, to evaluate their possible role in the disease's susceptibility and phenotype manifestations...
October 7, 2016: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/27536783/micrornas-expression-in-the-ileal-pouch-of-patients-with-ulcerative-colitis-is-robustly-up-regulated-and-correlates-with-disease-phenotypes
#8
Shay Ben-Shachar, Henit Yanai, Hadas Sherman Horev, Hofit Elad, Liran Baram, Ofer Issakov, Hagit Tulchinsky, Metsada Pasmanik-Chor, Noam Shomron, Iris Dotan
BACKGROUND: Gene expression alterations are associated with disease behavior in inflammatory bowel disease (IBD). microRNAs (miRNAs) are dominant in the regulation of gene expression, and may affect IBD phenotype. Our aim was to assess mucosal miRNA expression in IBD and the correlation with intestinal inflammation. METHODS: We performed a large-scale analysis of ileal mucosal miRNA. Biopsies were retrieved from patients with ileal Crohn's disease (CD), unoperated ulcerative colitis (UC) patients, UC patients after pouch surgery, and normal controls (NC)...
2016: PloS One
https://www.readbyqxmd.com/read/27525335/alpha-defensin-5-expression-is-regulated-by-micrornas-in-the-caco-2-intestinal-epithelial-cell-line
#9
Donald R B Miles, Jun Shen, Alice Y Chuang, Fenshi Dong, Feng Wu, John Kwon
BACKGROUND: In inflammatory bowel disease (IBD), an inappropriate immune response leads to chronic mucosal inflammation. This response may be partly due to dysregulation of defensins, which are endogenously produced antimicrobial peptides. This study determined whether microRNAs (miRNAs) regulate α-defensin 5 (DEFA5), which could further implicate both in IBD pathogenesis. METHODS: Induction of DEFA5 mRNA and protein expression was determined in Caco-2 cells. An in silico analysis identified putative miRNA binding sites of DEFA5...
April 2016: Journal of Inflammatory Bowel Diseases & Disorders
https://www.readbyqxmd.com/read/27416044/emerging-biomarkers-for-the-diagnosis-and-monitoring-of-inflammatory-bowel-diseases
#10
Anet A Soubières, Andrew Poullis
There is currently no single test available to confidently diagnose cases of inflammatory bowel disease (IBD). Physicians rely on a number of diagnostic tools, including clinical evaluation, serum testing, and imaging, which are used on conjunction with endoscopic evaluation. It is often difficult to determine whether patients with abdominal pain and change in bowel habit have functional bowel symptoms or whether they have a true diagnosis of IBD. Even once a diagnosis of IBD has been made, a significant proportion of patients are labeled with the term "indeterminate colitis" where histological sampling cannot confidently subclassify patients as either Crohn's or ulcerative colitis...
August 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27327245/fatty-acid-amide-hydrolase-faah-blockade-ameliorates-experimental-colitis-by-altering-microrna-expression-and-suppressing-inflammation
#11
Haidar Shamran, Narendra P Singh, Elizabeth E Zumbrun, Angela Murphy, Dennis D Taub, Manoj K Mishra, Robert L Price, Saurabh Chatterjee, Mitzi Nagarkatti, Prakash S Nagarkatti, Udai P Singh
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), which is thought to result from immune-mediated inflammatory disorders, leads to high morbidity and health care cost. Fatty acid amide hydrolase (FAAH) is an enzyme crucially involved in the modulation of intestinal physiology through anandamide (AEA) and other endocannabinoids. Here we examined the effects of an FAAH inhibitor (FAAH-II), on dextran sodium sulphate (DSS)-induced experimental colitis in mice. Treatments with FAAH-II improved overall clinical scores by reversing weight loss and colitis-associated pathogenesis...
June 17, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27318094/edible-ginger-derived-nanoparticles-a-novel-therapeutic-approach-for-the-prevention-and-treatment-of-inflammatory-bowel-disease-and-colitis-associated-cancer
#12
Mingzhen Zhang, Emilie Viennois, Meena Prasad, Yunchen Zhang, Lixin Wang, Zhan Zhang, Moon Kwon Han, Bo Xiao, Changlong Xu, Shanthi Srinivasan, Didier Merlin
There is a clinical need for new, more effective treatments for chronic and debilitating inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. In this study, we characterized a specific population of nanoparticles derived from edible ginger (GDNPs 2) and demonstrated their efficient colon targeting following oral administration. GDNPs 2 had an average size of ∼230 nm and exhibited a negative zeta potential. These nanoparticles contained high levels of lipids, a few proteins, ∼125 microRNAs (miRNAs), and large amounts of ginger bioactive constituents (6-gingerol and 6-shogaol)...
September 2016: Biomaterials
https://www.readbyqxmd.com/read/27220087/inflammatory-bowel-disease-exploring-gut-pathophysiology-for-novel-therapeutic-targets
#13
REVIEW
Vipul Yadav, Felipe Varum, Roberto Bravo, Esther Furrer, Daniela Bojic, Abdul W Basit
Ulcerative colitis and Crohn's disease are the 2 major phenotypes of inflammatory bowel disease (IBD), which are influenced by a complex interplay of immunological and genetic elements, though the precise etiology still remains unknown. With IBD developing into a globally prevailing disease, there is a need to explore new targets and a thorough understanding of the pathophysiological differences between the healthy and diseased gut could unearth new therapeutic opportunities. In this review, we provide an overview of the major aspects of IBD pathogenesis and thereafter present a comprehensive analysis of the gut pathophysiology leading to a discussion on some of the most promising targets and biologic therapies currently being explored...
October 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27138057/micrornas-how-many-in-inflammatory-bowel-disease
#14
Jeremy S Schaefer
PURPOSE OF REVIEW: MicroRNAs (miRNAs), small noncoding RNA molecules of approximately 22 nucleotides, have emerged as critical mediators of gene expression. As the dysregulation of gene expression can have far reaching impact on health and disease, miRNAs are being examined as potent new mediators of disease as either biomarkers or potential therapeutic targets. The purpose of this review is to evaluate the contribution of miRNAs to inflammatory bowel disease (IBD) pathophysiology. RECENT FINDINGS: Recent studies have evaluated the expression of miRNAs in tissue and body fluid specimens from patients with the main subtypes of IBD - Crohn's disease and ulcerative colitis...
July 2016: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/27119373/tnf%C3%AE-ifn%C3%AE-mediated-intestinal-epithelial-barrier-dysfunction-is-attenuated-by-microrna-93-downregulation-of-ptk6-in-mouse-colonic-epithelial-cells
#15
Ricci J Haines, Richard S Beard, Rebecca A Eitner, Liwei Chen, Mack H Wu
Since inflammatory bowel diseases (IBD) represent significant morbidity and mortality in the US, the need for defining novel drug targets and inflammatory mechanisms would be of considerable benefit. Although protein tyrosine kinase 6 (PTK6, also known as breast tumor kinase BRK) has been primarily studied in an oncogenic context, it was noted that PTK6 null mice exhibited significantly enhanced colonic epithelial barrier function. Considering that the inflammatory functions of PTK6 have not yet been explored, we hypothesized that cytokines responsible for mediating IBD, such as TNFα/IFNγ, may solicit the action of PTK6 to alter barrier function...
2016: PloS One
https://www.readbyqxmd.com/read/27113480/down-regulation-of-micrornas-of-the-mir-200-family-and-up-regulation-of-snail-and-slug-in-inflammatory-bowel-diseases-hallmark-of-epithelial-mesenchymal-transition
#16
Nina Zidar, Emanuela Boštjančič, Miha Jerala, Nika Kojc, David Drobne, Borut Štabuc, Damjan Glavač
Fibrosis is an important feature of inflammatory bowel diseases (IBD), particularly Crohn's disease (CD), but its pathogenesis is poorly understood. To determine the postulated involvement of epithelial-mesenchymal transition (EMT) in the development of fibrosis in IBD, we analysed the expression profiles of the miR-200 family which has been shown to induce EMT in experimental models and various human diseases. We also analysed the expression of Snail and Slug, postulated targets of the investigated microRNAs...
October 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27109937/association-between-microrna-polymorphisms-and-the-risk-of-inflammatory-bowel-disease
#17
Min Zhu, Diangeng Li, Meiling Jin, Mingyang Li
Common single nucleotide polymorphisms (SNPs) in precursor microRNAs may change their properties via altering the expression of miRNAs, resulting in diverse functional consequences. The present study evaluated the effects of four common SNPs in pro-miRNAs on the risk of inflammatory bowel disease (IBD) and IBD‑associated colorectal cancer (IBD-CRC). In a hospital based case‑control investigation in a Chinese population, 468 patients with IBD and 450 age- and gender-matched healthy subjects were enrolled in the present study...
June 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26878986/microrna-132-and-microrna-223-control-positive-feedback-circuit-by-regulating-foxo3a-in-inflammatory-bowel-disease
#18
Hye-Youn Kim, Hyeok Yi Kwon, Huyen Trang Ha Thi, Ho Jae Lee, Gwang Il Kim, Ki-Baek Hahm, Suntaek Hong
BACKGROUND AND AIM: Although many progresses have been achieved for inflammatory bowel disease (IBD), it is still remained as idiopathic disease to be completely controlled. MicroRNAs (miRNAs) have been identified as key players in many human diseases through degradation or translational inhibition of target genes. Because role of miRNAs in IBD is not completely understood yet, we need to identify miRNAs as novel targets for treatment of IBD. METHODS: Microarray analysis for miRNAs was performed using dextran sulfate sodium-induced colitis samples and selected differentially regulated miRNAs...
February 15, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26844512/circulating-microrna223-is-a-new-biomarker-for-inflammatory-bowel-disease
#19
Huiling Wang, Shenghong Zhang, Qiao Yu, Guang Yang, Jing Guo, Manying Li, Zhirong Zeng, Yao He, Baili Chen, Minhu Chen
Endoscopy is an important tool in screening and monitoring inflammatory bowel disease (IBD); however, it is invasive, costly, and associated with risks to the patients. Recently, circulating microRNAs (miRNAs) have emerged as promising noninvasive biomarkers. We proposed that the expression of serum microRNA223 (miR-223) could be a biomarker for IBD.Studies were conducted using serum samples from 100 patients with IBD (50 with Crohn's disease [CD] and 50 with ulcerative colitis [UC]) and 50 healthy controls...
February 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26647826/profiles-of-microrna-networks-in-intestinal-epithelial-cells-in-a-mouse-model-of-colitis
#20
Juneyoung Lee, Eun Jeong Park, Yoshikazu Yuki, Shandar Ahmad, Kenji Mizuguchi, Ken J Ishii, Motomu Shimaoka, Hiroshi Kiyono
Inflammatory bowel diseases (IBDs) accompany a critical loss of the frontline barrier function that is achieved primarily by intestinal epithelial cells (IECs). Although the gene-regulation pathways underlying these host-defense roles of IECs presumably are deranged during IBD pathogenesis, the quantitative and qualitative alterations of posttranscriptional regulators such as microRNAs (miRNAs) within the cells largely remain to be defined. We aimed to uncover the regulatory miRNA-target gene relationships that arise differentially in inflamed small- compared with large-IECs...
December 9, 2015: Scientific Reports
keyword
keyword
67301
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"