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microRNA IBD

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https://www.readbyqxmd.com/read/29420705/differential-expression-of-micrornas-in-peripheral-blood-mononuclear-cells-identifies-autophagy-and-tgf-beta-related-signatures-aberrantly-expressed-in-inflammatory-bowel-disease
#1
Aylia Mohammadi, Orlaith B Kelly, Melissa Filice, Boyko Kabakchiev, Michelle I Smith, Mark S Silverberg
Background and Aims: MicroRNAs (miRNAs) have emerged as important regulators in inflammatory bowel disease (IBD). This study investigated differential expression of miRNAs across clinical phenotypes in a well-characterized cohort of IBD patients and healthy controls (HCs). Methods: A cohort with Crohn's disease (CD), ulcerative colitis (UC), and HC was prospectively accrued. Total RNA was extracted from peripheral blood mononuclear cells for all subjects. MiRNA expression was measured using NanoString Technologies...
February 6, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29331376/microrna-425-facilitates-pathogenic-th17-cell-differentiation-by-targeting-forkhead-box-o1-foxo1-and-is-associated-with-inflammatory-bowel-disease
#2
Xue Yang, Qinyu He, Zhenzhen Guo, Fei Xiong, Yi Li, Yan Pan, Caiping Gao, Liangping Li, Chong He
Inflammatory bowel disease (IBD) is a chronic autoimmune disease, and its pathogenesis remains mostly unknown. MicroRNAs (miRs) has drawn much attention as a crucial regulator of autoimmune diseases. In this study, we demonstrated, for the first time, that miR-425 was significantly up-regulated in peripheral blood mononuclear cells (PBMC) and mucosa of patients with IBD. In note, T helper (Th) 17 cells were found to be the major source of miR-425 expression. Using gain-of-function approaches, we demonstrated that miR-425 could facilitate the differentiation of CD4+ T cells into Th17 lineage...
January 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29325325/-expression-of-microrna-155-in-inflammatory-bowel-disease-and-its-clinical-significance
#3
Y L Ye, Z Pang, W Gu, J J Zheng
Objective: To explore the expression of microRNA-155 in colonic mucosa and peripheral blood in patients with inflammatory bowel disease(IBD), and to examine the clinical value and significance of microRNA-155 in the diagnosis of IBD. Methods: Quatitative reverse-transcription PCR was performed to detect the expression of microRNA-155 in 20 patients with Crohn disease(CD), 21 patients with ulcerative colitis (UC), 18 patients with IBD type unclassified(IBDU), 25 healthy people(control group), 12 patients with infection colitis and 19 patients with ischemia colitis...
December 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29154194/micrornas-in-intestinal-barrier-function-inflammatory-bowel-disease-and-related-cancers-their-effects-and-therapeutic-potentials
#4
REVIEW
Esmerina Tili, Jean-Jacques Michaille, Victoria Piurowski, Brooke Rigot, Carlo M Croce
The initiation and development or inflammatory bowel disease (IBD) and associated colorectal cancers, have been linked to inflammation. MicroRNAs are non-coding regulators of gene expression that have gained great attention due to their capability to regulate the expression of a number of target transcripts. It is now generally admitted that microRNAs are instrumental in gut pathologies, in particular through their targeting of transcripts encoding proteins of the intestinal barrier (IB) and their regulators...
November 15, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29146677/functional-role-and-therapeutic-targeting-of-micrornas-in-inflammatory-bowel-disease
#5
Artin Soroosh, Marina Koutsioumpa, Charalabos Pothoulakis, Dimitrios Iliopoulos
Inflammatory Bowel Diseases (IBD) are chronic inflammatory gastrointestinal diseases, primarily consisting of Ulcerative Colitis (UC) and Crohn's Disease (CD). The complex nature of the disease, as well as the limited therapeutic options characterized by low efficiency and major side effects, shows the importance of developing novel strategies of therapeutic intervention in IBD. Susceptibility loci related to IBD are present only in a small percentage of IBD patients, implying that epigenetic modifications could influence the pathogenesis of the disease...
November 16, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29059189/inhibition-of-mir-142-5p-ameliorates-disease-in-mouse-models-of-experimental-colitis
#6
Nicolette W Duijvis, Perry D Moerland, Cindy Kunne, Monique M W Slaman, Faas H van Dooren, Esther W Vogels, Wouter J de Jonge, Sybren L Meijer, Kees Fluiter, Anje A Te Velde
BACKGROUND: MicroRNAs (miRNAs) are epigenetically involved in regulating gene expression. They may be of importance in the pathogenesis of inflammatory bowel disease (IBD). The aim of this study was to determine the role of miRNAs by their specific blocking in the CD4+CB45RBhi T-cell transfer model of chronic experimental colitis. METHODS: Colitis caused by transfer of WT CD4+CD45RBhi T cells in severe combined immunodeficiency (SCID) mice shares many features with human IBD...
2017: PloS One
https://www.readbyqxmd.com/read/29021788/micrornas-based-inter-domain-communication-between-the-host-and-members-of-the-gut-microbiome
#7
REVIEW
Maggie R Williams, Robert D Stedtfeld, James M Tiedje, Syed A Hashsham
The gut microbiome is an important modulator of host gene expression, impacting important functions such as the innate immune response. Recent evidence suggests that the inter-domain communication between the gut microbiome and host may in part occur via microRNAs (small, non-coding RNA molecules) which are often differentially expressed in the presence of bacteria and can even be released and taken up by bacteria. The role of microRNAs in microbiome-host communication in intestinal diseases is not fully understood, particularly in diseases impacted by exposure to environmental toxicants...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28946660/molecular-mechanisms-and-pathways-as-targets-for-cancer-prevention-and-progression-with-dietary-compounds
#8
REVIEW
Nagisa Nosrati, Marica Bakovic, Gopinadhan Paliyath
A unique feature of bioactive food ingredients is their broad antioxidant function. Antioxidants having a wide spectrum of chemical structure and activity beyond basic nutrition; display different health benefits by the prevention and progression of chronic diseases. Functional food components are capable of enhancing the natural antioxidant defense system by scavenging reactive oxygen and nitrogen species, protecting and repairing DNA damage, as well as modulating the signal transduction pathways and gene expression...
September 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28858208/inflammatory-diseases-and-growth-effects-on-the-gh-igf-axis-and-on-growth-plate
#9
REVIEW
Francesca Cirillo, Pietro Lazzeroni, Chiara Sartori, Maria Elisabeth Street
This review briefly describes the most common chronic inflammatory diseases in childhood, such as cystic fibrosis (CF), inflammatory bowel diseases (IBDs), juvenile idiopathic arthritis (JIA), and intrauterine growth restriction (IUGR) that can be considered, as such, for the changes reported in the placenta and cord blood of these subjects. Changes in growth hormone (GH) secretion, GH resistance, and changes in the insulin-like growth factor (IGF) system are described mainly in relationship with the increase in nuclear factor-κB (NF-κB) and pro-inflammatory cytokines...
August 31, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28774868/role-of-g-protein-coupled-receptors-microrna-interactions-in-gastrointestinal-pathophysiology
#10
Ivy Ka Man Law, David Miguel Padua, Dimitrios Ilopoulos, Charalabos Pothoulakis
G protein-coupled receptors (GPCRs) make up the largest transmembrane receptor superfamily in the human genome and are expressed in nearly all gastrointestinal (GI) cell types. Coupling of GPCRs and their respective ligands activates various phosphotransferase in the cytoplasm, and thus, activation of GPCR signaling in intestine regulates many cellular and physiological processes. Studies in microRNAs (miRNAs) demonstrate that they represent critical epigenetic regulators of different pathophysiologic responses in different organs and cell types in humans and animals...
August 3, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28726756/functional-implications-of-micrornas-in-crohn-s-disease-revealed-by-integrating-microrna-and-messenger-rna-expression-profiling
#11
Orazio Palmieri, Teresa Maria Creanza, Fabrizio Bossa, Tiziana Latiano, Giuseppe Corritore, Orazio Palumbo, Giuseppina Martino, Giuseppe Biscaglia, Daniela Scimeca, Massimo Carella, Nicola Ancona, Angelo Andriulli, Anna Latiano
Crohn's disease (CD) is a debilitating inflammatory bowel disease (IBD) that emerges due to the influence of genetic and environmental factors. microRNAs (miRNAs) have been identified in the tissue and sera of IBD patients and may play an important role in the induction of IBD. Our study aimed to identify differentially expressed miRNAs and miRNAs with the ability to alter transcriptome activity by comparing inflamed tissue samples with their non-inflamed counterparts. We studied changes in miRNA-mRNA interactions associated with CD by examining their differential co-expression relative to normal mucosa from the same patients...
July 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28627600/microrna%C3%A2-7%C3%A2-5p-regulates-the-expression-of-tff3-in-inflammatory-bowel-disease
#12
Jing Guo, Mei Sun, Xu Teng, Lingfen Xu
Trefoil factor 3 (TFF3) serves an important role in intestinal mucosal damage and healing, and contributes to the pathogenesis and treatment of inflammatory bowel disease (IBD). The aim of the present study was to determine the association between TFF3 and microRNA‑7‑5p (miR‑7‑5p) in IBD. Tissue immunohistochemistry was applied to evaluate the relative expression of TFF3, and reverse transcription‑quantitative polymerase chain reaction was performed to determine the expression of miR‑7‑5p in lesional tissue obtained from patients with IBD and healthy control tissues...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28487310/myeloid-derived-mir-223-regulates-intestinal-inflammation-via-repression-of-the-nlrp3-inflammasome
#13
Viola Neudecker, Moritz Haneklaus, Owen Jensen, Ludmila Khailova, Joanne C Masterson, Hazel Tye, Kathryn Biette, Paul Jedlicka, Kelley S Brodsky, Mark E Gerich, Matthias Mack, Avril A B Robertson, Matthew A Cooper, Glenn T Furuta, Charles A Dinarello, Luke A O'Neill, Holger K Eltzschig, Seth L Masters, Eóin N McNamee
MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how miRNA circuits orchestrate aberrant intestinal inflammation during inflammatory bowel disease (IBD) is poorly defined. Here, we report that miR-223 limits intestinal inflammation by constraining the nlrp3 inflammasome. miR-223 was increased in intestinal biopsies from patients with active IBD and in preclinical models of intestinal inflammation. miR-223-/y mice presented with exacerbated myeloid-driven experimental colitis with heightened clinical, histopathological, and cytokine readouts...
June 5, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28436302/gene-set-enrichment-analysis-a-genome-wide-expression-profile-based-strategy-for-discovering-functional-microrna-disease-relationships
#14
Yin Ni, Caiyun Song, Shuqing Jin, Zhoufeng Chen, Ming Ni, Lu Han, Jiansheng Wu, Yin Jin
Objective To explore stable and functional microRNA (miRNA)-disease relationships using a genome-wide expression profile pattern matching strategy. Methods We applied the ranked microarray pattern matching strategy Gene Set Enrichment Analysis to identify miRNA permutations with similar expression patterns to diseases. We also used quantitative reverse transcription PCR to validate the predicted expression levels of miRNAs in three diseases: inflammatory bowel disease (IBD), oesophageal cancer, and colorectal cancer...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28383678/microrna-mediated-dynamic-control-of-mucosal-immunity
#15
Eun Jeong Park, Motomu Shimaoka, Hiroshi Kiyono
The gastrointestinal tract is a complex and important physiological and immunological organ embodying the first line of defense by which mucosal immunity regulates the immense number and diversity of naturally encountered antigens and commensal microflora. Effective microRNA (miRNA) control of transcription factors or mediators in mucosal immunity is essential to host defense and homeostasis in both physiologic and pathologic states. MiRNA biology has advanced our understanding of the immune regulatory system network at the level of post-transcriptional gene modification...
April 1, 2017: International Immunology
https://www.readbyqxmd.com/read/28333149/upregulation-of-mir-665-promotes-apoptosis-and-colitis-in-inflammatory-bowel-disease-by-repressing-the-endoplasmic-reticulum-stress-components-xbp1-and-ormdl3
#16
Manying Li, Shenghong Zhang, Yun Qiu, Yao He, Baili Chen, Ren Mao, Yi Cui, Zhirong Zeng, Minhu Chen
MicroRNAs are critical post-transcriptional regulators of gene expression and key mediators of pathophysiology of inflammatory bowel disease (IBD). This study is aimed to study the role of miR-665 in the progression of IBD. Real-time PCR analysis was used to determine miR-665 expression in 89 freshly isolated IBD samples and dextran sulfate sodium (DSS)-induced colonic mucosal tissues. The role of miR-665 in inducing apoptosis and colitis were examined by Annexin V, TUNEL (terminal deoxynucleotidyl transferase dUTP nick-end labeling) staining, colony formation in vitro and DSS-induced colitis mice model in vivo...
March 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28301487/association-of-mir-196a-2-and-mir-499-variants-with-ulcerative-colitis-and-their-correlation-with-expression-of-respective-mirnas
#17
Raju Ranjha, Naresh Kumar Meena, Abhiraman Singh, Vineet Ahuja, Jaishree Paul
BACKGROUND AND AIM: MicroRNAs are small non-coding RNAs that play an important role in regulating the gene expression of their target genes. SNP miR-196a-2 rs11614913 and miR-499 rs3746444 are reported to have association with the risk and prognosis of multiple-types of inflammatory diseases including IBD. This study was conducted to show if any association of SNP miR-196a-2rs11614913 and miR-499 rs3746444 exists with ulcerative colitis (UC) patients of north Indian population and how these polymorphisms modulate the expression profile of the respective miRNAs...
2017: PloS One
https://www.readbyqxmd.com/read/28212924/ibd-immunopathogenesis-a-comprehensive-review-of-inflammatory-molecules
#18
REVIEW
Jae Hyon Park, Laurent Peyrin-Biroulet, Michael Eisenhut, Jae Il Shin
Inflammatory molecules play a crucial role in the pathogenesis of inflammatory bowel disease (IBD) such as ulcerative colitis and Crohn's disease, both of which are chronic inflammatory conditions of the gastrointestinal tract. Abnormal expressions of pro- and anti-inflammatory molecules have been described to cause an imbalance to the gut innate and adaptive immunity, and recently a large portion of research in IBD has been geared towards identifying novel molecules that may be used as potential therapeutic targets...
April 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28193514/microrna-301a-promotes-intestinal-inflammation-and-colitis-associated-cancer-development-by-inhibiting-btg1
#19
Chong He, Tianming Yu, Yan Shi, Caiyun Ma, Wenjing Yang, Leilei Fang, Mingming Sun, Wei Wu, Fei Xiao, Feifan Guo, Minhu Chen, Hong Yang, Jiaming Qian, Yingzi Cong, Zhanju Liu
BACKGROUND & AIMS: Intestinal tissues from patients with inflammatory bowel disease (IBD) and colorectal cancer have increased expression of microRNA-301a (MIR301A) compared with tissues from patients without IBD. We studied the mechanisms of MIR301A in the progression of IBD in human tissues and mice. METHODS: We isolated intestinal epithelial cells (IECs) from biopsy samples of the colon from 153 patients with different stages of IBD activity, 6 patients with colitis-associated cancer (CAC), and 35 healthy individuals (controls), enrolled in the study in Shanghai, China...
May 2017: Gastroenterology
https://www.readbyqxmd.com/read/28077249/altered-mucosal-expression-of-micrornas-in-pediatric-patients-with-inflammatory-bowel-disease
#20
Nóra Judit Béres, Zoltán Kiss, Zsófia Sztupinszki, Gábor Lendvai, András Arató, Erna Sziksz, Ádám Vannay, Attila J Szabó, Katalin Eszter Müller, Áron Cseh, Kriszta Boros, Gábor Veres
INTRODUCTION: MicroRNAs (miRs) came recently into focus as promising novel research targets offering new insights into the pathogenesis of inflammatory bowel diseases (IBD). AIMS: The aim of our study was to identify a pediatric IBD (pIBD) characteristic miR profile serving as potential Crohn's disease (CD) and ulcerative colitis (UC) specific diagnostic pattern and to further analyze the related target genes. METHODS: Small RNA sequencing was performed on inflamed and intact colonic biopsies of CD, and control patients...
April 2017: Digestive and Liver Disease
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