Sagnik Nag, Oishi Mitra, Garima Tripathi, Souvik Samanta, Bikramjit Bhattacharya, Priti Chandane, Sourav Mohanto, Vino Sundararajan, Sumira Malik, Sarvesh Rustagi, Suraj Adhikari, Aroop Mohanty, Darwin A León-Figueroa, Alfonso J Rodriguez-Morales, Joshuan J Barboza, Ranjit Sah
BACKGROUND: Autoimmune diseases (AD) are severe pathophysiological ailments that are stimulated by an exaggerated immunogenic response towards self-antigens, which can cause systemic or site-specific organ damage. An array of complex genetic and epigenetic facets majorly contributes to the progression of AD, thus providing significant insight into the regulatory mechanism of microRNA (miRNA). miRNAs are short, non-coding RNAs that have been identified as essential contributors to the post-transcriptional regulation of host genome expression and as crucial regulators of a myriad of biological processes such as immune homeostasis, T helper cell differentiation, central and peripheral tolerance, and immune cell development...
December 2023: Immunity, Inflammation and Disease