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microRNA IBD

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https://www.readbyqxmd.com/read/29608690/loss-of-microrna-21-influences-the-gut-microbiota-causing-reduced-susceptibility-in-a-murine-model-of-colitis
#1
Daniel G W Johnston, Michelle A Williams, Christoph A Thaiss, Raul Cabrera-Rubio, Mathilde Raverdeau, Craig McEntee, Paul D Cotter, Eran Elinav, Luke A J O'Neill, Sinéad C Corr
Background and aims: microRNAs regulate gene expression and influence the pathogenesis of human diseases. The present study investigated miR-21 in the pathogenesis of intestinal inflammation, as miR-21 is highly expressed in Inflammatory Bowel Disease (IBD). IBD is associated with intestinal barrier dysfunction and an altered gut microbiota. Recent studies have demonstrated that host microRNAs can shape the microbiota. Thus, we determined the influence of miR-21 on the gut microbiota and subsequent impact in a dextran sodium sulphate (DSS)-induced colitis model...
March 28, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29564226/gga-mir-155-enhances-type-i-interferon-expression-and-suppresses-infectious-burse-disease-virus-replication-via-targeting-socs1-and-tank
#2
Bin Wang, Mengjiao Fu, Yanan Liu, Yongqiang Wang, Xiaoqi Li, Hong Cao, Shijun J Zheng
Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by IBD virus (IBDV). MicroRNAs (miRNAs) are involved in host-pathogen interactions and innate immune response to viral infection. However, the role of miRNAs in host response to IBDV infection is not clear. We report here that gga-miR-155 acts as an anti-virus host factor inhibiting IBDV replication. We found that transfection of DF-1 cells with gga-miR-155 suppressed IBDV replication, while blockage of the endogenous gga-miR-155 by inhibitors enhanced IBDV replication...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29560130/stromal-mir-20a-controls-paracrine-cxcl8-secretion-in-colitis-and-colon-cancer
#3
Steven A Signs, Robert C Fisher, Uyen Tran, Susmita Chakrabarti, Samaneh K Sarvestani, Shao Xiang, David Liska, Veronique Roche, Wei Lai, Haley R Gittleman, Oliver Wessely, Emina H Huang
Inflammatory bowel disease (IBD) affects one million people in the US. Ulcerative colitis (UC) is a subtype of IBD that can lead to colitis-associated cancer (CAC). In UC, the rate of CAC is 3-5-fold greater than the rate of sporadic colorectal cancer (CRC). The pathogenesis of UC and CAC are due to aberrant interactions between host immune system and microenvironment, but precise mechanisms are still unknown. In colitis and CAC, microenvironmental fibroblasts exhibit an activated, inflammatory phenotype that contributes to tumorigenesis accompanied by excessive secretion of the chemokine CXCL8...
February 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29550454/microrna-146a-5p-attenuates-visceral-hypersensitivity-through-targeting-chemokine-ccl8-in-the-spinal-cord-in-a-mouse-model-of-colitis
#4
Ying Lu, De-Li Cao, Lin-Xia Zhao, Yu Han, You-Li Zhang
Visceral pain, observed in inflammatory bowel disease (IBD) patients, is a challenging medical problem and remains poorly understood because the mechanisms underlying it are unclear. Emerging evidence indicates that microRNAs (miRNAs) play a crucial role in the pathogenesis of acute and chronic pain. In this study, we aimed to explore the potential role of miR-146a-5p (the mature form of miR-146a) in a mouse model of colitis induced by intracolonic injection of trinitrobenzene sulfonic acid (TNBS). We found that induction of colitis resulted in visceral hyperalgesia manifested by a decreased pain threshold to colorectal distension and upregulation of miR-146a-5p expression in the lumbosacral spinal cord...
March 14, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29472916/fortunellin-induced-modulation-of-phosphatase-and-tensin-homolog-by-microrna-374a-decreases-inflammation-and-maintains-intestinal-barrier-function-in-colitis
#5
Yongjian Xiong, Juanjuan Qiu, Changyi Li, Yang Qiu, Li Guo, Yuejian Liu, Jiajia Wan, Yuchun Li, Guokai Wu, Liang Wang, Zijuan Zhou, Jianyi Dong, Chunhua Du, Dapeng Chen, Huishu Guo
Activation of phosphatase and tensin homolog (PTEN) is known to induce cell apoptosis. MicroRNA-374a (miR-374a), which can suppress PTEN expression, has been found abnormally expressed in inflammatory bowel disease (IBD). Fortunellin is a citrus flavonoid that is a potential anti-inflammation agent in inflammatory diseases. The present study investigated the effects and mechanisms underlying fortunellin-induced inhibition of PTEN in IBD. Colitis was established in rats by the intracolonic administration of 2,4,6-trinitrobenzene sulfonic acid to mimic human ulcerative colitis, which is the main type of IBD...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29420705/differential-expression-of-micrornas-in-peripheral-blood-mononuclear-cells-identifies-autophagy-and-tgf-beta-related-signatures-aberrantly-expressed-in-inflammatory-bowel-disease
#6
Aylia Mohammadi, Orlaith B Kelly, Melissa Filice, Boyko Kabakchiev, Michelle I Smith, Mark S Silverberg
Background and Aims: MicroRNAs (miRNAs) have emerged as important regulators in inflammatory bowel disease (IBD). This study investigated differential expression of miRNAs across clinical phenotypes in a well-characterized cohort of IBD patients and healthy controls (HCs). Methods: A cohort with Crohn's disease (CD), ulcerative colitis (UC), and HC was prospectively accrued. Total RNA was extracted from peripheral blood mononuclear cells for all subjects. MiRNA expression was measured using NanoString Technologies...
February 6, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29331376/microrna-425-facilitates-pathogenic-th17-cell-differentiation-by-targeting-forkhead-box-o1-foxo1-and-is-associated-with-inflammatory-bowel-disease
#7
Xue Yang, Qinyu He, Zhenzhen Guo, Fei Xiong, Yi Li, Yan Pan, Caiping Gao, Liangping Li, Chong He
Inflammatory bowel disease (IBD) is a chronic autoimmune disease, and its pathogenesis remains mostly unknown. MicroRNAs (miRs) has drawn much attention as a crucial regulator of autoimmune diseases. In this study, we demonstrated, for the first time, that miR-425 was significantly up-regulated in peripheral blood mononuclear cells (PBMC) and mucosa of patients with IBD. In note, T helper (Th) 17 cells were found to be the major source of miR-425 expression. Using gain-of-function approaches, we demonstrated that miR-425 could facilitate the differentiation of CD4+ T cells into Th17 lineage...
February 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29325325/-expression-of-microrna-155-in-inflammatory-bowel-disease-and-its-clinical-significance
#8
Y L Ye, Z Pang, W Gu, J J Zheng
Objective: To explore the expression of microRNA-155 in colonic mucosa and peripheral blood in patients with inflammatory bowel disease(IBD), and to examine the clinical value and significance of microRNA-155 in the diagnosis of IBD. Methods: Quatitative reverse-transcription PCR was performed to detect the expression of microRNA-155 in 20 patients with Crohn disease(CD), 21 patients with ulcerative colitis (UC), 18 patients with IBD type unclassified(IBDU), 25 healthy people(control group), 12 patients with infection colitis and 19 patients with ischemia colitis...
December 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29154194/micrornas-in-intestinal-barrier-function-inflammatory-bowel-disease-and-related-cancers-their-effects-and-therapeutic-potentials
#9
REVIEW
Esmerina Tili, Jean-Jacques Michaille, Victoria Piurowski, Brooke Rigot, Carlo M Croce
The initiation and development or inflammatory bowel disease (IBD) and associated colorectal cancers, have been linked to inflammation. MicroRNAs are non-coding regulators of gene expression that have gained great attention due to their capability to regulate the expression of a number of target transcripts. It is now generally admitted that microRNAs are instrumental in gut pathologies, in particular through their targeting of transcripts encoding proteins of the intestinal barrier (IB) and their regulators...
December 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29146677/functional-role-and-therapeutic-targeting-of-micrornas-in-inflammatory-bowel-disease
#10
Artin Soroosh, Marina Koutsioumpa, Charalabos Pothoulakis, Dimitrios Iliopoulos
Inflammatory bowel diseases (IBD) are chronic inflammatory gastrointestinal diseases, primarily consisting of ulcerative colitis and Crohn's disease. The complex nature of the disease, as well as the limited therapeutic options characterized by low efficiency and major side effects, highlights the importance of developing novel strategies of therapeutic intervention in IBD. Susceptibility loci related to IBD are present only in a small percentage of IBD patients, implying that epigenetic modifications could influence the pathogenesis of the disease...
February 1, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29059189/inhibition-of-mir-142-5p-ameliorates-disease-in-mouse-models-of-experimental-colitis
#11
Nicolette W Duijvis, Perry D Moerland, Cindy Kunne, Monique M W Slaman, Faas H van Dooren, Esther W Vogels, Wouter J de Jonge, Sybren L Meijer, Kees Fluiter, Anje A Te Velde
BACKGROUND: MicroRNAs (miRNAs) are epigenetically involved in regulating gene expression. They may be of importance in the pathogenesis of inflammatory bowel disease (IBD). The aim of this study was to determine the role of miRNAs by their specific blocking in the CD4+CB45RBhi T-cell transfer model of chronic experimental colitis. METHODS: Colitis caused by transfer of WT CD4+CD45RBhi T cells in severe combined immunodeficiency (SCID) mice shares many features with human IBD...
2017: PloS One
https://www.readbyqxmd.com/read/29021788/micrornas-based-inter-domain-communication-between-the-host-and-members-of-the-gut-microbiome
#12
REVIEW
Maggie R Williams, Robert D Stedtfeld, James M Tiedje, Syed A Hashsham
The gut microbiome is an important modulator of host gene expression, impacting important functions such as the innate immune response. Recent evidence suggests that the inter-domain communication between the gut microbiome and host may in part occur via microRNAs (small, non-coding RNA molecules) which are often differentially expressed in the presence of bacteria and can even be released and taken up by bacteria. The role of microRNAs in microbiome-host communication in intestinal diseases is not fully understood, particularly in diseases impacted by exposure to environmental toxicants...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28946660/molecular-mechanisms-and-pathways-as-targets-for-cancer-prevention-and-progression-with-dietary-compounds
#13
REVIEW
Nagisa Nosrati, Marica Bakovic, Gopinadhan Paliyath
A unique feature of bioactive food ingredients is their broad antioxidant function. Antioxidants having a wide spectrum of chemical structure and activity beyond basic nutrition; display different health benefits by the prevention and progression of chronic diseases. Functional food components are capable of enhancing the natural antioxidant defense system by scavenging reactive oxygen and nitrogen species, protecting and repairing DNA damage, as well as modulating the signal transduction pathways and gene expression...
September 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28858208/inflammatory-diseases-and-growth-effects-on-the-gh-igf-axis-and-on-growth-plate
#14
REVIEW
Francesca Cirillo, Pietro Lazzeroni, Chiara Sartori, Maria Elisabeth Street
This review briefly describes the most common chronic inflammatory diseases in childhood, such as cystic fibrosis (CF), inflammatory bowel diseases (IBDs), juvenile idiopathic arthritis (JIA), and intrauterine growth restriction (IUGR) that can be considered, as such, for the changes reported in the placenta and cord blood of these subjects. Changes in growth hormone (GH) secretion, GH resistance, and changes in the insulin-like growth factor (IGF) system are described mainly in relationship with the increase in nuclear factor-κB (NF-κB) and pro-inflammatory cytokines...
August 31, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28774868/role-of-g-protein-coupled-receptors-microrna-interactions-in-gastrointestinal-pathophysiology
#15
REVIEW
Ivy Ka Man Law, David Miguel Padua, Dimitrios Iliopoulos, Charalabos Pothoulakis
G protein-coupled receptors (GPCRs) make up the largest transmembrane receptor superfamily in the human genome and are expressed in nearly all gastrointestinal cell types. Coupling of GPCRs and their respective ligands activates various phosphotransferases in the cytoplasm, and, thus, activation of GPCR signaling in intestine regulates many cellular and physiological processes. Studies in microRNAs (miRNAs) demonstrate that they represent critical epigenetic regulators of different pathophysiological responses in different organs and cell types in humans and animals...
November 1, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28726756/functional-implications-of-micrornas-in-crohn-s-disease-revealed-by-integrating-microrna-and-messenger-rna-expression-profiling
#16
Orazio Palmieri, Teresa Maria Creanza, Fabrizio Bossa, Tiziana Latiano, Giuseppe Corritore, Orazio Palumbo, Giuseppina Martino, Giuseppe Biscaglia, Daniela Scimeca, Massimo Carella, Nicola Ancona, Angelo Andriulli, Anna Latiano
Crohn's disease (CD) is a debilitating inflammatory bowel disease (IBD) that emerges due to the influence of genetic and environmental factors. microRNAs (miRNAs) have been identified in the tissue and sera of IBD patients and may play an important role in the induction of IBD. Our study aimed to identify differentially expressed miRNAs and miRNAs with the ability to alter transcriptome activity by comparing inflamed tissue samples with their non-inflamed counterparts. We studied changes in miRNA-mRNA interactions associated with CD by examining their differential co-expression relative to normal mucosa from the same patients...
July 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28627600/microrna%C3%A2-7%C3%A2-5p-regulates-the-expression-of-tff3-in-inflammatory-bowel-disease
#17
Jing Guo, Mei Sun, Xu Teng, Lingfen Xu
Trefoil factor 3 (TFF3) serves an important role in intestinal mucosal damage and healing, and contributes to the pathogenesis and treatment of inflammatory bowel disease (IBD). The aim of the present study was to determine the association between TFF3 and microRNA‑7‑5p (miR‑7‑5p) in IBD. Tissue immunohistochemistry was applied to evaluate the relative expression of TFF3, and reverse transcription‑quantitative polymerase chain reaction was performed to determine the expression of miR‑7‑5p in lesional tissue obtained from patients with IBD and healthy control tissues...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28487310/myeloid-derived-mir-223-regulates-intestinal-inflammation-via-repression-of-the-nlrp3-inflammasome
#18
Viola Neudecker, Moritz Haneklaus, Owen Jensen, Ludmila Khailova, Joanne C Masterson, Hazel Tye, Kathryn Biette, Paul Jedlicka, Kelley S Brodsky, Mark E Gerich, Matthias Mack, Avril A B Robertson, Matthew A Cooper, Glenn T Furuta, Charles A Dinarello, Luke A O'Neill, Holger K Eltzschig, Seth L Masters, Eóin N McNamee
MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how miRNA circuits orchestrate aberrant intestinal inflammation during inflammatory bowel disease (IBD) is poorly defined. Here, we report that miR-223 limits intestinal inflammation by constraining the nlrp3 inflammasome. miR-223 was increased in intestinal biopsies from patients with active IBD and in preclinical models of intestinal inflammation. miR-223-/y mice presented with exacerbated myeloid-driven experimental colitis with heightened clinical, histopathological, and cytokine readouts...
June 5, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28436302/gene-set-enrichment-analysis-a-genome-wide-expression-profile-based-strategy-for-discovering-functional-microrna-disease-relationships
#19
Yin Ni, Caiyun Song, Shuqing Jin, Zhoufeng Chen, Ming Ni, Lu Han, Jiansheng Wu, Yin Jin
Objective To explore stable and functional microRNA (miRNA)-disease relationships using a genome-wide expression profile pattern matching strategy. Methods We applied the ranked microarray pattern matching strategy Gene Set Enrichment Analysis to identify miRNA permutations with similar expression patterns to diseases. We also used quantitative reverse transcription PCR to validate the predicted expression levels of miRNAs in three diseases: inflammatory bowel disease (IBD), oesophageal cancer, and colorectal cancer...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28383678/microrna-mediated-dynamic-control-of-mucosal-immunity
#20
Eun Jeong Park, Motomu Shimaoka, Hiroshi Kiyono
The gastrointestinal tract is a complex and important physiological and immunological organ embodying the first line of defense by which mucosal immunity regulates the immense number and diversity of naturally encountered antigens and commensal microflora. Effective microRNA (miRNA) control of transcription factors or mediators in mucosal immunity is essential to host defense and homeostasis in both physiologic and pathologic states. MiRNA biology has advanced our understanding of the immune regulatory system network at the level of post-transcriptional gene modification...
April 1, 2017: International Immunology
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