keyword
https://read.qxmd.com/read/38536471/prevalence-of-swallowing-disorder-in-different-dementia-subtypes-among-older-adults-a-meta-analysis
#1
JOURNAL ARTICLE
Alfiani Rahmi Putri, Yu-Hao Chu, Ruey Chen, Kai-Jo Chiang, Kondwani Joseph Banda, Doresses Liu, Hui-Chen Lin, Shu-Fen Niu, Kuei-Ru Chou
BACKGROUND: Ageing process and abnormal protein accumulation in dementia damage neural pathways affecting the swallowing process and leading to swallowing disorder. OBJECTIVE: To estimate the prevalence of swallowing disorder among older adults with different dementia subtypes. METHODS: We conducted a systematic search across multiple databases, including PubMed, Embase, Scopus, Web of Science and OVID Medline. The meta-analysis employed R (version 4...
March 1, 2024: Age and Ageing
https://read.qxmd.com/read/38536448/arterial-spin-labelling-magnetic-resonance-imaging-and-perfusion-patterns-in-neurocognitive-and-other-mental-disorders-a-systematic-review
#2
REVIEW
Rita Ferreira, António J Bastos-Leite
We reviewed 33 original research studies assessing brain perfusion, using consensus guidelines from a "white paper" issued by the International Society for Magnetic Resonance in Medicine Perfusion Study Group and the European Cooperation in Science and Technology Action BM1103 ("Arterial Spin Labelling Initiative in Dementia"; https://www.cost.eu/actions/BM1103/ ). The studies were published between 2011 and 2023 and included participants with subjective cognitive decline plus; neurocognitive disorders, including mild cognitive impairment (MCI), Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), dementia with Lewy bodies (DLB) and vascular cognitive impairment (VCI); as well as schizophrenia spectrum disorders, bipolar and major depressive disorders, autism spectrum disorder, attention-deficit/hyperactivity disorder, panic disorder and alcohol use disorder...
March 27, 2024: Neuroradiology
https://read.qxmd.com/read/38527854/connecting-dementia-risk-loci-to-the-csf-proteome-identifies-pathophysiological-leads-for-dementia
#3
JOURNAL ARTICLE
Lianne M Reus, Iris E Jansen, Betty M Tijms, Pieter Jelle Visser, Niccoló Tesi, Sven J van der Lee, Lisa Vermunt, Carel F W Peeters, Lisa A De Groot, Yanaika S Hok-A-Hin, Alice Chen-Plotkin, David J Irwin, William T Hu, Lieke H Meeter, John C van Swieten, Henne Holstege, Marc Hulsman, Afina W Lemstra, Yolande A L Pijnenburg, Wiesje M van der Flier, Charlotte E Teunissen, Marta Del Campo Milan
Genome-wide association studies have successfully identified many genetic risk loci for dementia, but exact biological mechanisms through which genetic risk factors contribute to dementia remains unclear. Integrating CSF proteomic data with dementia risk loci could reveal intermediate molecular pathways connecting genetic variance to the development of dementia. We tested to what extent effects of known dementia risk loci can be observed in CSF levels of 665 proteins (proximity extension-based (PEA) immunoassays) in a deeply-phenotyped mixed-memory clinic cohort (n=502, mean age (sd) = 64...
March 25, 2024: Brain
https://read.qxmd.com/read/38520489/disentangling-and-quantifying-the-relative-cognitive-impact-of-concurrent-mixed-neurodegenerative-pathologies
#4
JOURNAL ARTICLE
Carolina Maldonado-Díaz, Satomi Hiya, Raquel T Yokoda, Kurt Farrell, Gabriel A Marx, Justin Kauffman, Elena V Daoud, Mitzi M Gonzales, Alicia S Parker, Leyla Canbeldek, Lakshmi Shree Kulumani Mahadevan, John F Crary, Charles L White, Jamie M Walker, Timothy E Richardson
Neurodegenerative pathologies such as Alzheimer disease neuropathologic change (ADNC), Lewy body disease (LBD), limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC), and cerebrovascular disease (CVD) frequently coexist, but little is known about the exact contribution of each pathology to cognitive decline and dementia in subjects with mixed pathologies. We explored the relative cognitive impact of concurrent common and rare neurodegenerative pathologies employing multivariate logistic regression analysis adjusted for age, gender, and level of education...
March 23, 2024: Acta Neuropathologica
https://read.qxmd.com/read/38519009/neuropsychiatric-symptoms-profile-and-markers-of-alzheimer-disease-type-pathology-in-patients-with-lewy-body-dementias
#5
JOURNAL ARTICLE
Chaofan Geng, Leilei Tan, Chenchen
BACKGROUND: To determine whether Lewy body dementia (LBD) patients with likely copathology of Alzheimer's disease (AD) exhibit greater neuropsychiatric symptom (NPS) compared to those without likely AD-type copathology. METHODS: We enrolled 69 individuals diagnosed with Lewy body dementia (LBD), comprising both dementia with Lewy bodies (DLB) (n = 36) and Parkinson's disease dementia (PDD) (n = 33). These participants had accessible cerebrospinal fluid (CSF) markers related to Alzheimer's disease (AD) and cognitive data...
March 20, 2024: Brain Research
https://read.qxmd.com/read/38517586/the-role-of-123-i-mibg-cardiac-scintigraphy-in-the-differential-diagnosis-between-dementia-with-lewy-bodies-and-alzheimer-s-disease
#6
REVIEW
Giacomo Monzio Compagnoni, Ildebrando Appollonio, Carlo Ferrarese
Although detailed diagnostic guidelines are available, differentiating dementia with Lewy bodies from Alzheimer's disease is often difficult. 123-I-MIBG cardiac scintigraphy is one of the tools which have been proposed for the diagnostic procedure. The present review is aimed at evaluating the available literature about this topic. Studies assessing the use of this technique to differentiate between the two diseases have been examined and reported. Overall, despite a certain study-to-study variability, the available literature suggests that 123-I-MIBG cardiac scintigraphy is an effective tool in differentiating between the two diseases, with high sensitivity and specificity values...
March 22, 2024: Neurological Sciences
https://read.qxmd.com/read/38517469/remote-evaluation-of-sleep-and-circadian-rhythms-in-older-adults-with-mild-cognitive-impairment-and-dementia-protocol-for-a-feasibility-and-acceptability-mixed-methods-study
#7
JOURNAL ARTICLE
Victoria Grace Gabb, Jonathan Blackman, Hamish Duncan Morrison, Bijetri Biswas, Haoxuan Li, Nicholas Turner, Georgina M Russell, Rosemary Greenwood, Amy Jolly, William Trender, Adam Hampshire, Alan Whone, Elizabeth Coulthard
BACKGROUND: Sleep disturbances are a potentially modifiable risk factor for neurodegenerative dementia secondary to Alzheimer disease (AD) and Lewy body disease (LBD). Therefore, we need to identify the best methods to study sleep in this population. OBJECTIVE: This study will assess the feasibility and acceptability of various wearable devices, smart devices, and remote study tasks in sleep and cognition research for people with AD and LBD. METHODS: We will deliver a feasibility and acceptability study alongside a prospective observational cohort study assessing sleep and cognition longitudinally in the home environment...
March 22, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38512130/distinctive-whole-brain-cell-types-predict-tissue-damage-patterns-in-thirteen-neurodegenerative-conditions
#8
JOURNAL ARTICLE
Veronika Pak, Quadri Adewale, Danilo Bzdok, Mahsa Dadar, Yashar Zeighami, Yasser Iturria-Medina
For over a century, brain research narrative has mainly centered on neuron cells. Accordingly, most neurodegenerative studies focus on neuronal dysfunction and their selective vulnerability, while we lack comprehensive analyses of other major cell types' contribution. By unifying spatial gene expression, structural MRI, and cell deconvolution, here we describe how the human brain distribution of canonical cell types extensively predicts tissue damage in 13 neurodegenerative conditions, including early- and late-onset Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, amyotrophic lateral sclerosis, mutations in presenilin-1, and 3 clinical variants of frontotemporal lobar degeneration (behavioral variant, semantic and non-fluent primary progressive aphasia) along with associated three-repeat and four-repeat tauopathies and TDP43 proteinopathies types A and C...
March 21, 2024: ELife
https://read.qxmd.com/read/38510209/ventra-distinguishing-frontotemporal-dementia-from-psychiatric-disorders
#9
JOURNAL ARTICLE
Ana L Manera, Mahsa Dadar, Simon Ducharme, D Louis Collins
The volume of the lateral ventricles is a reliable and sensitive indicator of brain atrophy and disease progression in behavioural variant frontotemporal dementia. In this study, we validate our previously developed automated tool using ventricular features (known as VentRa) for the classification of behavioural variant frontotemporal dementia versus a mixed cohort of neurodegenerative, vascular and psychiatric disorders from a clinically representative independent dataset. Lateral ventricles were segmented for 1110 subjects-14 behavioural variant frontotemporal dementia, 30 other frontotemporal dementia, 70 Lewy body disease, 898 Alzheimer's disease, 62 vascular brain injury and 36 primary psychiatric disorder from the publicly accessible National Alzheimer's Coordinating Center dataset to assess the performance of VentRa...
2024: Brain communications
https://read.qxmd.com/read/38505993/the-complement-system-in-neurodegenerative-diseases
#10
JOURNAL ARTICLE
Jacqui Nimmo, Robert A J Byrne, Nikoleta Daskoulidou, Lewis M Watkins, Sarah M Carpanini, Wioleta M Zelek, B Paul Morgan
Complement is an important component of innate immune defence against pathogens and crucial for efficient immune complex disposal. These core protective activities are dependent in large part on properly regulated complement-mediated inflammation. Dysregulated complement activation, often driven by persistence of activating triggers, is a cause of pathological inflammation in numerous diseases, including neurological diseases. Increasingly, this has become apparent not only in well-recognized neuroinflammatory diseases like multiple sclerosis but also in neurodegenerative and neuropsychiatric diseases where inflammation was previously either ignored or dismissed as a secondary event...
March 20, 2024: Clinical Science (1979-)
https://read.qxmd.com/read/38499535/htra1-disaggregates-%C3%AE-synuclein-amyloid-fibrils-and-converts-them-into-non-toxic-and-seeding-incompetent-species
#11
JOURNAL ARTICLE
Sheng Chen, Anuradhika Puri, Braxton Bell, Joseph Fritsche, Hector H Palacios, Maurie Balch, Macy L Sprunger, Matthew K Howard, Jeremy J Ryan, Jessica N Haines, Gary J Patti, Albert A Davis, Meredith E Jackrel
Parkinson's disease (PD) is closely linked to α-synuclein (α-syn) misfolding and accumulation in Lewy bodies. The PDZ serine protease HTRA1 degrades fibrillar tau, which is associated with Alzheimer's disease, and inactivating mutations to mitochondrial HTRA2 are implicated in PD. Here, we report that HTRA1 inhibits aggregation of α-syn as well as FUS and TDP-43, which are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The protease domain of HTRA1 is necessary and sufficient for inhibiting aggregation, yet this activity is proteolytically-independent...
March 18, 2024: Nature Communications
https://read.qxmd.com/read/38497429/delineating-cognitive-resilience-using-fractal-regulation-cross-sectional-and-longitudinal-evidence-from-the-rush-memory-and-aging-project
#12
JOURNAL ARTICLE
Peng Li, Chenlu Gao, Lei Yu, Lei Gao, Ruixue Cai, David A Bennett, Julie A Schneider, Aron S Buchman, Kun Hu
INTRODUCTION: Degradation of fractal patterns in actigraphy independently predicts dementia risk. Such observations motivated the study to understand the role of fractal regulation in the context of neuropathologies. METHODS: We examined associations of fractal regulation with neuropathologies and longitudinal cognitive changes in 533 older participants who were followed annually with actigraphy and cognitive assessments until death with brain autopsy performed...
March 18, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38496508/deep-sequencing-of-proteotoxicity-modifier-genes-uncovers-a-presenilin-2-beta-amyloid-actin-genetic-risk-module-shared-among-alpha-synucleinopathies
#13
Sumaiya Nazeen, Xinyuan Wang, Dina Zielinski, Isabel Lam, Erinc Hallacli, Ping Xu, Elizabeth Ethier, Ronya Strom, Camila A Zanella, Vanitha Nithianandam, Dylan Ritter, Alexander Henderson, Nathalie Saurat, Jalwa Afroz, Andrew Nutter-Upham, Hadar Benyamini, Joseph Copty, Shyamsundar Ravishankar, Autumn Morrow, Jonathan Mitchel, Drew Neavin, Renuka Gupta, Nona Farbehi, Jennifer Grundman, Richard H Myers, Clemens R Scherzer, John Q Trojanowski, Vivianna M Van Deerlin, Antony A Cooper, Edward B Lee, Yaniv Erlich, Susan Lindquist, Jian Peng, Daniel H Geschwind, Joseph Powell, Lorenz Studer, Mel B Feany, Shamil R Sunyaev, Vikram Khurana
Whether neurodegenerative diseases linked to misfolding of the same protein share genetic risk drivers or whether different protein-aggregation pathologies in neurodegeneration are mechanistically related remains uncertain. Conventional genetic analyses are underpowered to address these questions. Through careful selection of patients based on protein aggregation phenotype (rather than clinical diagnosis) we can increase statistical power to detect associated variants in a targeted set of genes that modify proteotoxicities...
March 7, 2024: bioRxiv
https://read.qxmd.com/read/38491466/causal-relationship-between-dietary-salt-intake-and-dementia-risk-mendelian-randomization-study
#14
JOURNAL ARTICLE
Ke Shi, Yongbo Yu, Zhaolin Li, Miaomiao Hou, Xinyi Li
OBJECTIVE: Observational research has indicated a potential link between dietary salt intake and susceptibility to dementia. However, it is important to note that these types of studies are prone to the issues of reverse causation and residual confounding. Therefore, we conducted a two-sample Mendelian randomization (MR) study to explore the causality. METHOD: To explore the causal relationship between them, this Mendelian randomization (MR) study incorporated summary statistics of dietary salt intake and dementia...
March 15, 2024: Genes & Nutrition
https://read.qxmd.com/read/38481342/differences-in-the-treatment-needs-of-patients-with-dementia-with-lewy-bodies-and-their-caregivers-and-differences-in-their-physicians-awareness-of-those-treatment-needs-according-to-the-clinical-department-visited-by-the-patients-a-subanalysis-of-an-observational
#15
JOURNAL ARTICLE
Manabu Ikeda, Shunji Toya, Yuta Manabe, Hajime Yamakage, Mamoru Hashimoto
BACKGROUND: We investigated whether the treatment needs of patients with dementia with Lewy bodies (DLB) and their caregivers, along with their attending physicians' perception of those treatment needs, differ according to the clinical department visited by the patients. METHODS: This was a subanalysis of a multicenter, cross-sectional, observational survey study. Data from the main study were classified according to the clinical department visited by the patient: psychiatric group (P-group), geriatric internal medicine group (G-group), and neurology group (N-group)...
March 14, 2024: Alzheimer's Research & Therapy
https://read.qxmd.com/read/38477399/longitudinal-free-water-changes-in-dementia-with-lewy-bodies
#16
JOURNAL ARTICLE
Shannon Y Chiu, Robin Chen, Wei-En Wang, Melissa J Armstrong, Bradley F Boeve, Rodolfo Savica, Vijay Ramanan, Julie A Fields, Neill Graff-Radford, Tanis J Ferman, Kejal Kantarci, David E Vaillancourt
BACKGROUND: Diffusion-weighted magnetic resonance imaging (dMRI) examines tissue microstructure integrity in vivo. Prior dementia with Lewy bodies (DLB) diffusion tensor imaging studies yielded mixed results. OBJECTIVE: We employed free-water (FW) imaging to assess DLB progression and correlate with clinical decline in DLB. METHODS: Baseline and follow-up MRIs were obtained at 12 and/or 24 months for 27 individuals with DLB or mild cognitive impairment with Lewy bodies (MCI-LB)...
March 13, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38471417/psychosis-in-alzheimer-s-disease-is-associated-with-specific-changes-in-brain-mri-volume-cognition-and-neuropathology
#17
JOURNAL ARTICLE
Francisco C Almeida, Tiago Jesus, Ana Coelho, Miguel Quintas-Neves, Kathryn Gauthreaux, Merilee A Teylan, Charles N Mock, Walter A Kukull, John F Crary, Tiago Gil Oliveira
Psychosis in Alzheimer's Disease (AD) is prevalent and indicates poor prognosis. However, the neuropathological, cognitive and brain atrophy patterns underlying these symptoms have not been fully elucidated. In this study, we evaluated 178 patients with AD neuropathological change (ADNC) and ante-mortem volumetric brain magnetic resonance imaging (MRI). Presence of psychosis was determined using the Neuropsychiatric Inventory Questionnaire. Clinical Dementia Rating Sum-of-boxes (CDR-SB) was longitudinally compared between groups with a follow-up of 3000 days using mixed-effects multiple linear regression...
March 2, 2024: Neurobiology of Aging
https://read.qxmd.com/read/38470687/investigation-of-the-approaches-to-optimal-exercise-interventions-based-on-dementia-type-a-theoretical-review
#18
REVIEW
Hyun Lee, Hyeongmin Lee, Jinhyung Choi, Gyujeong Hwang, Hyemin Lee, Hyunmin Lee, Sujeong Kim, Minjeong Kim, Huiju Nam, Jaeyoon Shim, Hatem Jaber, Jongeun Yim
The aim of this study is to enhance comprehension of the different types and features of dementia, including their symptoms, diagnosis and medical treatment, and to propose various evidence-based exercise interventions and their clinical applications tailored to each specific type of dementia. The theoretical review includes the analysis of publications in the scientific databases PubMed/Medline, Ebsco, Scielo, and Google. A total of 177 articles were found, of which 84 were studied in depth. With the prevalence of all forms of dementia projected to increase from 57...
March 1, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38468042/fractal-analysis-in-neurodegenerative-diseases
#19
JOURNAL ARTICLE
Daniel Pirici, Laurentiu Mogoanta, Daniela Adriana Ion, Samir Kumar-Singh
Neurodegenerative diseases are defined by progressive nervous system dysfunction and death of neurons. The abnormal conformation and assembly of proteins is suggested to be the most probable cause for many of these neurodegenerative disorders, leading to the accumulation of abnormally aggregated proteins, for example, amyloid β (Aβ) (Alzheimer's disease and vascular dementia), tau protein (Alzheimer's disease and frontotemporal lobar degeneration), α-synuclein (Parkinson's disease and Lewy body dementia), polyglutamine expansion diseases (Huntington disease), or prion proteins (Creutzfeldt-Jakob disease)...
2024: Advances in Neurobiology
https://read.qxmd.com/read/38461502/attention-deficit-hyperactivity-disorder-as-a-potential-risk-factor-for-dementia-and-other-neurocognitive-disorders-a-systematic-review
#20
Rachel H Carr, Gina D Eom, Eric E Brown
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD), a common neurodevelopmental condition now recognized to persist into older adulthood, has been postulated to be a risk factor for neurocognitive disorders given the overlap in clinical features and neurobiology, as well as the complex interplay between ADHD and known risk factors for dementia. Studies have emerged assessing this relationship, but there has not yet been a comprehensive systematic review addressing this topic...
March 2, 2024: Journal of Alzheimer's Disease: JAD
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