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Organ donation

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https://www.readbyqxmd.com/read/29782354/criteria-to-identify-a-potential-deceased-organ-donor-a-systematic-review
#1
Janet E Squires, Mary Coughlin, Kristin Dorrance, Stefanie Linklater, Michaël Chassé, Jeremy M Grimshaw, Sam D Shemie, Sonny Dhanani, Gregory A Knoll
OBJECTIVES: To systematically review the global published literature defining a potential deceased organ donor and identifying clinical triggers for deceased organ donation identification and referral. DATA SOURCES: Medline and Embase databases from January 2006 to September 2017. STUDY SELECTION: All published studies containing a definition of a potential deceased organ donor and/or clinical triggers for referring a potential deceased organ donor were eligible for inclusion...
May 18, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29781880/willingness-to-donate-organs-among-people-living-with-hiv
#2
Anh Q Nguyen, Saad K Anjum, Samantha E Halpern, Komal Kumar, Sarah E Van Pilsum Rasmussen, Brianna Doby, Ashton A Shaffer, Allan B Massie, Aaron A R Tobian, Dorry L Segev, Jeremy Sugarman, Christine M Durand
BACKGROUND: With passage of the HIV Organ Policy Equity (HOPE) Act, people living with HIV (PLWH) can donate organs to PLWH awaiting transplant. Understanding knowledge and attitudes regarding organ donation among PLWH in the US is critical to implementing the HOPE Act. METHODS: PLWH were surveyed regarding their knowledge, attitudes, and beliefs about organ donation and transplantation at an urban academic HIV clinic in Baltimore, MD between 08/2016-10/2016. Responses were compared using Fisher's exact and chi-squared tests...
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29780535/-de-novo-design-of-d-%C3%AF-a-molecules-as-universal-hosts-for-monochrome-and-white-phosphorescent-organic-light-emitting-diodes
#3
Wen-Cheng Chen, Yi Yuan, Ze-Lin Zhu, Zuo-Quan Jiang, Shi-Jian Su, Liang-Sheng Liao, Chun-Sing Lee
Two novel D-σ-A host materials 11,11-bis(9-phenyl-9 H -carbazol-3-yl)-11 H -benzo[4,5]imidazo[1,2- a ]indole (BII-BCz) and 4,4'-(11 H -benzo[4,5]imidazo[1,2- a ]indole-11,11-diyl)bis( N , N -diphenylaniline) (BII-TPA) are synthesized by using the sp3 carbon attached to a newly designed 11 H -benzo[4,5]imidazo[1,2- a ]indole building block to link two electron-donating groups. The resulting materials feature high triplet energy levels, good thermal properties and suitable photophysical properties as universal hosts for full-color phosphorescent organic light-emitting diodes (OLEDs)...
May 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29778713/concluding-commentary-on-current-trends-to-enhance-the-clinical-safety-of-pediatric-transfusion-focusing-on-prevention-of-untoward-complications-of-hsc-transplantation-newer-strategies-for-improving-the-standards-of-safety-quality-of-stem-cells-expansion-for
#4
REVIEW
Irena Sniecinski, Jerard Seghatchian
Clinical practice and related diagnostic, development and research [DDR] strategies in pediatric transfusion and transplantation cover a broad range of multidisciplinary studies, performed by many professionals involved in this most challenging clinical field [1]. This commentary on the current position and future perspectives in pediatric transfusion field is aimed to highlight major unresolved transfusion complications in pediatric patients, namely red blood cell and platelet alloimmunisation, and new ones such as nosocomial infection, thrombosis and multi-organ failure...
May 16, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29777247/knowledge-and-attitudes-of-intensive-care-unit-healthcare-workers-towards-human-organ-donation-in-singapore
#5
Sheila Wee, Caroline Ong, Yie Hui Lau
No abstract text is available yet for this article.
April 2018: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29776812/preservation-with-%C3%AE-1-antitrypsin-improves-primary-graft-function-of-murine-lung-transplants
#6
Jessica Götzfried, Natalia F Smirnova, Carmela Morrone, Brice Korkmaz, Ali Önder Yildirim, Oliver Eickelberg, Dieter E Jenne
BACKGROUND: Vascular damage and primary graft dysfunction increase with prolonged preservation times of transplanted donor lungs. Hence, storage and conservation of donated lungs in protein-free, dextran-containing electrolyte solutions, like Perfadex, is limited to about 6 hours. We hypothesized that transplanted lungs are protected against neutrophil-mediated proteolytic damage by adding α1 -anti-trypsin (AAT), a highly abundant human plasma proteinase inhibitor, to Perfadex. METHODS: A realistic clinically oriented murine model of lung transplantation was used to simulate the ischemia-reperfusion process...
March 30, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29775831/an-exploratory-analysis-of-spatial-variations-in-organ-donation-registration-rates-in-wales-prior-to-the-implementation-of-the-human-transplantation-wales-act-2013
#7
Nicholas Page, Gary Higgs, Mitchel Langford
Spatial variations in rates of registered organ donors have not been studied in the UK at detailed spatial scales despite some evidence of national and regional differences. By drawing on the findings from the existing literature, this study examines associations between small-area variations in rates of new registrants to the UK organ donor register (ODR) within Wales and key demographic factors. Using map-based visualisations and statistical regression methods, spatial patterns in new registrants to the ODR are identified within Wales, a country which moved to an opt-out system of consent for organ donation following the Human Transplantation (Wales) Act 2013...
May 15, 2018: Health & Place
https://www.readbyqxmd.com/read/29773965/funds-allocation-in-npos-the-role-of-administrative-cost-ratios
#8
Christian Burkart, Tina Wakolbinger, Fuminori Toyasaki
Performance measurement of Non-Profit Organizations (NPOs) is of increasing importance for aid agencies, policy-makers and donors. A widely used benchmark for measuring the efficiency of NPOs is the overhead cost ratio, consisting of the total money spent on administration and fundraising relative to the budget. Donors generally favor a lower overhead cost ratio as it ensures that more money directly reaches beneficiaries. Unlike fundraising expenses, administrative costs do not contribute to advertising the actions of an NPO even though they account for a significant proportion of overhead cost...
2018: Central European Journal of Operations Research
https://www.readbyqxmd.com/read/29768930/a-strategic-planning-tool-for-increasing-african-american-blood-donation
#9
Ashley Singleton, Regena Spratling
Historically, African Americans (AAs) have been underrepresented as blood donors. Having a lack of racially diverse blood donors contributes to transfusion complications, particularly in patients with sickle cell disease, who are both disproportionately AA and the recipients of frequent transfusions. Increasing AA blood donation is a complex public health issue. This review article serves to fill a gap in translating research regarding known hindrances and facilitators of AA blood donation to improve real-world donation practice and ultimately, patient outcomes...
May 1, 2018: Health Promotion Practice
https://www.readbyqxmd.com/read/29766774/factors-associated-with-health-care-professionals-attitude-toward-the-presumed-consent-system
#10
Makmor Tumin, Khaled Tafran, NurulHuda Mohd Satar, Ng Kok Peng, Rishya Manikam, Tang Li Yoong, Chong Mei Chan
OBJECTIVES: This paper explores health care professionals' potential attitude toward organ donation if the presumed consent system were to be implemented in Malaysia, as well as factors associated with this attitude. MATERIALS AND METHODS: We used self-administered questionnaires to investigate the attitude of 382 health care professionals from the University of Malaya Medical Center between January and February 2014. The responses were analyzed using logistic regression...
May 16, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29765938/utilizing-benzotriazole-and-indacenodithiophene-units-to-construct-both-polymeric-donor-and-small-molecular-acceptors-to-realize-organic-solar-cells-with-high-open-circuit-voltages-beyond-1-2-v
#11
Ailing Tang, Fan Chen, Bo Xiao, Jing Yang, Jianfeng Li, Xiaochen Wang, Erjun Zhou
Devolopment of organic solar cells with high open-circuit voltage ( V OC ) and power conversion efficiency (PCE) simutaniously plays a significant role, but there is no guideline how to choose the suitable photovoltaic material combinations. In our previous work, we developed "the Same-Acceptor-Strategy" (SAS), by utilizing the same electron-accepting segment to construct both polymeric donor and small molecular acceptor. In this study, we further expend SAS to use both the same electron-accepting and electron-donating units to design the material combination...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29763391/should-trauma-physicians-treat-a-severely-injured-patient-for-the-sake-of-elucidating-preferences-about-organ-donation
#12
Sandra R DiBrito, Macey L Henderson
Organ donation potential is not a motivator of care in the trauma bay, and it is ethically problematic to consider organ donor potential during the active resuscitation of a trauma patient. Despite organ donation being a public good, the role of the trauma physician is to maintain focus on the patient as an individual and to respect a patient's right to life and autonomy. This tenet of medicine is the foundation of the trust that a community and individuals must have in order for the health care system to function...
May 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29762420/experience-and-perception-in-organ-donation-a-matter-of-team-work
#13
Anne-Marie Lagacé, Emmanuel Charbonney, Pierre Marsolais
No abstract text is available yet for this article.
June 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29756994/new-insights-into-complicated-grief-in-bereaved-family-members-approached-for-organ-donation
#14
James Downar
No abstract text is available yet for this article.
May 14, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29756746/factors-influencing-consent-to-organ-donation-after-brain-death-certification-a-survey-of-29-intensive-care-units
#15
Guya Piemonte, Maria L Migliaccio, Stefano Bambi, Marco Bombardi, Lorenzo D'antonio, Andrea Guazzini, Caterina Di Pasquale, Laura Tadini-Buoninsegni, Cristiana Guetti, Manuela Bonizzoli, Sara Bagatti, Paolo Lopane, Anna Nativi, Laura Rasero, Adriano Peris
BACKGROUND: Family refusal (FR) to heart beating donation (HBD) in Intensive Care Unit (ICU) is increasing in recent years with a significant impact on the number of transplantable organs. Fostering setting humanization, quality of relationships, respect for will and family reliance towards ICU could be relevant in containing FR to organ donation (OD) in ICU. Our aims were to highlight the effects of structural features of ICUs and humanization determinants on FR in HBD process, and to describe visiting policies, structure and modalities of support in ICUs...
May 14, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29752920/direct-heart-procurement-following-donation-after-circulatory-death-with-ex-situ-reperfusion
#16
Hassiba Smail, Diana Garcia Saez, Ulrich Stock, Hesham Ahmed Hassan, Christopher Bowles, Barlomiej Zych, Prashant N Mohite, Olaf Maunz, Andre R Simon
The most extended technique of Heart procurement from donors after circulatory death (DCD)involves direct procurement and reperfusion in ex situ normothermic platform using Organ Care System (OCS). We describe a modified technique at our institution with rapid donor blood drainage using a cell saver and synchronised perfusion on the OCS.
May 9, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29751317/quantitative-structure-activity-relationship-for-the-oxidation-of-aromatic-organic-contaminants-in-water-by-taml-h-2-o-2
#17
Hanrui Su, Chunyang Yu, Yongfeng Zhou, Lidong Gong, Qilin Li, Pedro J J Alvarez, Mingce Long
Tetra-amido macrocyclic ligand (TAML) activator is a functional analog of peroxidase enzymes, which activates hydrogen peroxide (H2 O2 ) to form high valence iron-oxo complexes that selectively degrade persistent aromatic organic contaminants (ACs) in water. Here, we develop quantitative structure-activity relationship (QSAR) models based on measured pseudo first-order kinetic rate coefficients (kobs ) of 29 ACs (e.g., phenols and pharmaceuticals) oxidized by TAML/H2 O2 at neutral and basic pH values to gain mechanistic insight on the selectivity and pH dependence of TAML/H2 O2 systems...
May 2, 2018: Water Research
https://www.readbyqxmd.com/read/29747596/hand-assisted-living-donor-nephrectomy-a-retrospective-comparison-of-two-techniques
#18
Jeannette D Widmer, Andrea Schlegel, Philipp Kron, Marc Schiesser, Jens G Brockmann, Markus K Muller
BACKGROUND: Living-donor nephrectomy (LDN) is challenging, as surgery is performed on healthy individuals. Minimally invasive techniques for LDN have become standard in most centers. Nevertheless, numerous techniques have been described with no consensus on which is the superior approach. Both hand-assisted retroperitoneoscopic (HARS) and hand-assisted laparoscopic (HALS) LDNs are performed at Zurich University Hospital. The aim of this study was to compare these two surgical techniques in terms of donor outcome and graft function...
May 10, 2018: BMC Urology
https://www.readbyqxmd.com/read/29744049/role-of-biobanks-in-transplantation
#19
REVIEW
Z Hanif, N Sufiyan, M Patel, M Z Akhtar
The establishment of bio-banks together with high throughput technologies, such as genomics, transcriptomics and proteomics has opened new frontiers in biomarker discovery and the development of systems biology approaches to identifying key pathways that could be exploited to improve outcomes of solid organ transplantation. One of the major challenges in organ donation has been the lack of access to large scale well characterised material to facilitate projects that aim to characterise injury to donor organs and identify biomarkers...
April 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29742390/20th-anniversary-of-isolation-of-human-embryonic-stem-cells-a-personal-perspective
#20
REVIEW
Joseph Itskovitz-Eldor
Following Jamie Thomson's lecture on primate embryonic stem cells (ESCs) at a meeting I had organized in March 1997, in Israel, to celebrate receipt of the Wolf Prize in Agriculture to my colleague and friend Neal First, frozen human embryos donated for research in Israel were shipped to Wisconsin. The five hESC lines (H1, H7, H9, H13, and H14) were established by early 1998 and transferred to my laboratory just before publication of their existence in Science, on November 6, 1998. The distribution of the cells from my institute to several laboratories, as early as 1999, enhanced the development of hESC research worldwide...
May 8, 2018: Stem Cell Reports
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