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Organ donation

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https://www.readbyqxmd.com/read/29354869/organ-donor-pancreases-for-the-study-of-human-islet-cell-histology-and-pathophysiology-a-precious-and-valuable-resource
#1
EDITORIAL
Piero Marchetti, Mara Suleiman, Lorella Marselli
Direct in vivo assessment of pancreatic islet-cells for the study of the pathophysiology of diabetes in humans is hampered by anatomical and technological hurdles. To date, most of the information that has been generated is derived from histological studies performed on pancreatic tissue from autopsy, surgery, in vivo biopsy or organ donation. Each approach has its advantages and disadvantages (as summarised in this commentary); however, in this edition of Diabetologia, Kusmartseva et al ( https://doi.org/10...
January 21, 2018: Diabetologia
https://www.readbyqxmd.com/read/29354178/the-role-of-extracorporeal-membrane-oxygenation-in-patients-after-irreversible-cardiac-arrest-as-potential-organ-donors
#2
REVIEW
Tomasz Kłosiewicz, Mateusz Puślecki, Marcin Zieliński, Michał Mandecki, Marcin Ligowski, Sebastian Stefaniak, Marek Dąbrowski, Marek Karczewski, Łukasz Gąsiorowski, Maciej Sip, Agata Dąbrowska, Wojciech Telec, Bartłomiej Perek, Marek Jemielity
The number of people waiting for a kidney or liver transplant is growing systematically. Due to the latest advances in transplantation, persons after irreversible cardiac arrest and confirmation of death have become potential organ donors. It is estimated that they may increase the number of donations by more than 40%. However, without good organization and communication between pre-hospital care providers, emergency departments, intensive care units and transplantation units, it is almost impossible to save the organs of potential donors in good condition...
December 2017: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/29353669/transmission-of-dengue-virus-from-deceased-donors-to-solid-organ-transplant-recipients-case-report-and-literature-review
#3
Fernando Rosso, Juan C Pineda, Ana M Sanz, Jorge A Cedano, Luis A Caicedo
Dengue fever is a vector-transmitted viral infection. Non-vectorial forms of transmission can occur through organ transplantation. We reviewed medical records of donors and recipients with suspected dengue in the first post-transplant week. We used serologic and molecular analysis to confirm the infection. Herein, we describe four cases of dengue virus transmission through solid organ transplantation. The recipients had positive serology and RT-PCR. Infection in donors was detected through serology. All cases presented with fever within the first week after transplantation...
January 18, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29350532/design-of-exceptionally-strong-organic-superbases-based-on-aromatic-pnictogen-oxides-a-computational-dft-analysis-of-the-oxygen-basicity-in-the-gas-phase-and-acetonitrile-solution
#4
Tana Tandaric, Robert Vianello
DFT B3LYP calculations convincingly showed that aromatic pnictogen-oxides offer scaffolds suitable for tailoring powerful organic superbases exhibiting exceptional oxygen basicity in both gas-phase and polar aprotic acetonitrile solution. With their protonation enthalpies and pKa values, they surpass the basicity of classical proton sponges and related nitrogen bases. The most potent system is provided with two arsenic-oxide moieties on the phenanthrene framework assisted with the two phosphazeno groups in the para-position to both basic centers...
January 19, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29349948/case-report-of-kidney-paired-donation-kpd-with-desensitization-the-strategy-and-experience-of-3-way-kpd-in-samsung-medical-center
#5
Dongkyu Oh, Eun Suk Kang, Shinae Yu, Kyoungsuk Chun, Wooseong Huh, Hye Ryoun Jang, Chan Woo Cho, Nuri Lee, Kyo Won Lee, Hyojun Park, Jae Berm Park, Sung Joo Kim
As the need for the organ donation increases, strategies to increase kidney transplantation (KT) through expanded living donation have become essential. These include kidney paired donation (KPD) programs and desensitization in incompatible transplantations. KPD enables kidney transplant candidates with incompatible living donors to join a registry with other incompatible pairs in order to find potentially compatible living donor. Positive cross match and ABO incompatible transplantation has been successfully accomplished in selective cases with several pre-conditionings...
January 29, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29349884/report-of-a-human-autopsy-case-in-maxillary-sinuses-augmented-using-a-synthetic-bone-substitute-micro-computed-tomographic-and-histologic-observations
#6
Jung-Seok Lee, Jae-Kook Cha, Daniel S Thoma, Ui-Won Jung
OBJECTIVE: This study of a human autopsy case aimed to characterize the histologic and micro-computed tomographic results of maxillary sinus augmentation using a synthetic bone substitute and simultaneous implant placement at 6 years. MATERIAL AND METHODS: This report is based on the whole-body donation of a 62-year-old male patient who died due to bladder cancer. Implants had been placed in conjunction with sinus augmentation using a mixture of biphasic calcium phosphate and autogenous bone into both maxillary sinuses 6 years prior to the body donation...
January 18, 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29346640/preventive-chemotherapy-to-control-soil-transmitted-helminthiasis-averted-more-than-500-000-dalys-in-2015
#7
A Montresor, W Trouleau, D Mupfasoni, M Bangert, S A Joseph, A Mikhailov, C Fitzpatrick
Background: Preventive chemotherapy (PC), the large-scale administration of anthelminthics, is recommended by the World Health Organization (WHO) for the control of soil-transmitted helminthiasis (STH). Since 2010, donated anthelminthics for STH have boosted the implementation of PC programmes in children, achieving global coverage of more than 60% in 2015. The WHO Global Health Estimates attribute an annual loss of over 3.3 million disability-adjusted life-years (DALYs) to STH. The aim of this study is to estimate the impact of PC programmes on child morbidity...
January 16, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29346262/important-facts-about-organ-donation-and-opo-performance
#8
David S Goldberg, Teresa Shafer, Laura Siminoff
No abstract text is available yet for this article.
January 18, 2018: Transplantation
https://www.readbyqxmd.com/read/29346254/long-term-outcomes-of-pediatric-en-bloc-kidney-transplantation-a-single-center-experience-with-25-years-follow-up
#9
Kalathil K Sureshkumar, Amr Habbach, Amy Tang, Bhavna Chopra
BACKGROUND: Pediatric en bloc kidneys are considered marginal for transplantation into adults. We aimed to compare the long-term outcomes of pediatric en bloc vs. living donor kidney transplantation. METHODS: A retrospective review was undertaken on pediatric en bloc and living donor kidney transplants performed at our center between 1990 and 2001. The outcomes compared between the groups included 25 year graft survival and longitudinal glomerular filtration rate (GFR)...
January 18, 2018: Transplantation
https://www.readbyqxmd.com/read/29341338/human-teeth-biobank-microbiological-analysis-of-the-teeth-storage-solution
#10
Fabiana Almeida Curylofo-Zotti, Francine Lorencetti-Silva, Jéssica de Almeida Coelho, Rachel Maciel Monteiro, Evandro Watanabe, Silmara Aparecida Milori Corona
The cross-infections may occur during handling of dental elements, affecting the health of dental practitioners and researchers. This study aimed to analyze the influence of the storage medium temperature on the bacterial contingent of the human teeth used for research purposes. Thirty human teeth were donated to the Human Teeth Biobank immediately after extraction. The teeth were cleaned with tap water and neutral soap. The teeth were randomly distributed according to the temperature of the storage solution (deionized water): at 4 °C (refrigerator) or at -10 °C (freezer) and were stored individually in sterile vials during 60 days...
January 17, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29338388/novel-fusion-protein-targeting-mitochondrial-dna-improves-pancreatic-islet-functional-potency-and-islet-transplantation-outcomes
#11
Juan S Danobeitia, Peter J Chlebeck, Inna Shokolenko, Xiaobo Ma, Glenn Wilson, Luis A Fernandez
Long-term graft survival is an ongoing challenge in the field of islet transplantation. With the growing demand for transplantable organs, therapies to improve organ quality and reduce the incidence of graft dysfunction are of paramount importance. We evaluated the protective role of a recombinant DNA repair protein targeted to mitochondria (Exscien I-III), as a therapeutic agent using a rodent model of pancreatic islet transplantation. We first investigated the effect of therapy on isolated rat islets cultured with pro-inflammatory cytokines (interleukin-1 β, interferon γ, and tumor necrosis factor α) for 48 h and documented a significant reduction in apoptosis by flow cytometry, improved viability by immunofluorescence, and conserved functional potency in vitro and in vivo in Exscien I-III-treated islets...
November 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29336548/judicious-design-of-cationic-cyclometalated-ir-iii-complexes-for-photochemical-energy-conversion-and-optoelectronics
#12
Isaac N Mills, Jonathan A Porras, Stefan Bernhard
The exponential growth in published studies on phosphorescent metal complexes has been triggered by their utilization in optoelectronics, solar energy conversion, and biological labeling applications. Very recent breakthroughs in organic photoredox transformations have further increased the research efforts dedicated to discerning the inner workings and structure-property relationships of these chromophores. Initially, the principal focus was on the Ru(II)-tris-diimine complex family. However, the limited photostability and lack of luminescence tunability discovered in these complexes prompted a broadening of the research to include 5d transition metal ions...
January 16, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29334151/fused-tris-thienothiophene-based-electron-acceptor-with-strong-near-infrared-absorption-for-high-performance-as-cast-solar-cells
#13
Tengfei Li, Shuixing Dai, Zhifan Ke, Langxuan Yang, Jiayu Wang, Cenqi Yan, Wei Ma, Xiaowei Zhan
A fused tris(thienothiophene) (3TT) building block is designed and synthesized with strong electron-donating and molecular packing properties, where three thienothiophene units are condensed with two cyclopentadienyl rings. Based on 3TT, a fused octacylic electron acceptor (FOIC) is designed and synthesized, using strong electron-withdrawing 2-(5/6-fluoro-3-oxo-2,3-dihydro-1H-inden-1-ylidene)-malononitrile as end groups. FOIC exhibits absorption in 600-950 nm region peaked at 836 nm with extinction coefficient of up to 2 × 105 m-1 cm-1 , low bandgap of 1...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29333823/brain-death-and-organ-donation-in-argentine-pediatric-intensive-care-units-a-multicenter-study
#14
Germán Bonetto, Pedro Taffarel, Melisa Gamerman, Facundo Jorro Barón, Carolina Gaviña, Laura Flores, Emanuel Fernández, Andrea Zifferman, Gustavo Debaisi, Marcelo Acerenza, Jorge Selandari, Luis Landry, Ariel Cacciamano, Alfredo Clavel, Patricia Capocasa, Bernardo Calvo, Marcial Angos
Brain death (BD) is a condition determined by the complete and irreversible absence of brain functions. Maintenance of vital functions creates an opportunity for organ donation. A retrospective study was carried out in 7 pediatric intensive care units of Argentina (from 1/1/2013 to 9/30/2016) to determine the incidence of clinical and certified BD, and the proportion of effective transplantations. Among deceased patients, 19.14% (147/768) met the clinical requirements for BD, and the main cause of BD was multiple trauma...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29332204/supplementing-living-kidney-transplantees-medical-records-with-donor-and-recipient-narratives
#15
Anne Hambro Alnæs
Norway provides total social welfare coverage for organ transplantations, including free immunosuppressive medication and prepaid life-long follow up for both recipients and donors. Despite these benefits the proportion of living kidney donors (LKD) has in recent years declined from around 40% (2011) of all kidney transplantations to 24% (2016). This study suggests harnessing patient- and donor-narratives as a tool for addressing the current fall in donation rates. The hospital records of 18 recipient/donor dyads were compared with patient and donor accounts elicited in semi-structured interviews...
January 13, 2018: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/29331633/organ-donation-in-the-icu-a-document-analysis-of-institutional-policies-protocols-and-order-sets
#16
Simon J W Oczkowski, John E Centofanti, Pamela Durepos, Erika Arseneau, Julija Kelecevic, Deborah J Cook, Maureen O Meade
OBJECTIVE: To better understand how local policies influence organ donation rates. RESEARCH METHODOLOGY/DESIGN: We conducted a document analysis of our ICU organ donation policies, protocols and order sets. We used a systematic search of our institution's policy library to identify documents related to organ donation. We used Mindnode software to create a publication timeline, basic statistics to describe document characteristics, and qualitative content analysis to extract document themes...
January 10, 2018: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/29329190/landscape-of-living-multi-organ-donation-in-the-united-states-a-registry-based-cohort-study
#17
Macey L Henderson, Sandra R DiBrito, Alvin G Thomas, Courtenay M Holscher, Ashton A Shaffer, Mary Grace Bowring, Tanjala S Purnell, Allan B Massie, Jacqueline Garonzik-Wang, Madeleine Waldram, Krista L Lentine, Dorry L Segev
BACKGROUND: The donation of multiple allografts from a single living donor is a rare practice, and the patient characteristics and outcomes associated with these procedures are not well described. METHODS: Using the SRTR registry, we identified 101 living multi-organ donors and their 133 recipients. RESULTS: The 49 sequential (donations during separate procedures) multi-organ donors provided grafts to 81 recipients: 21 kidney-then-liver, 15 liver-then-kidney, 5 lung-then-kidney, 3 liver-then-intestine, 3 kidney-then-pancreas, 1 lung-then-liver, and 1 pancreas-then-kidney...
January 11, 2018: Transplantation
https://www.readbyqxmd.com/read/29325914/micro-cultural-customization-of-organ-donation-propagation-messages
#18
Anke Dunkel, Kent Nakamoto, Peter J Schulz
OBJECTIVE: Organ transplantation is plagued by limited availability of organs. This study investigated the effect of messages promoting organ donation which were customized according to the language-defined micro-cultures in Switzerland. METHODS: Community-, informative-, and emotional-oriented messages were carried by conventional flyers. A 3 × 3 between-subjects experiment was conducted with short- and long-term willingness to donate, long-term signing of organ donation card and long-term interpersonal communication on organ donation as outcome variables...
December 29, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/29323479/solution-processed-n-type-graphene-doping-for-cathode-in-inverted-polymer-light-emitting-diodes
#19
Sung-Joo Kwon, Tae-Hee Han, Young-Hoon Kim, Towfiq Ahmed, Hong-Kyu Seo, Hobeom Kim, Dong Jin Kim, Wentao Xu, Byung Hee Hong, Jian-Xin Zhu, Tae-Woo Lee
n-Type doping with (4-(1,3-dimethyl-2,3-dihydro-1H-benzoimidazol-2-yl)phenyl) dimethylamine (N-DMBI) reduces a work function (WF) of graphene by ~0.45 eV without significant reduction of optical transmittance. Solution process of N-DMBI on graphene provides effective n-type doping effect and air-stability at the same time. Although neutral N-DMBI act as an electron receptor leaving the graphene p-doped, radical N-DMBI acts as an electron donator leaving the graphene n-doped, which is demonstrated by density functional theory...
January 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29322327/combined-and-sequential-liver-kidney-transplantation-in-children
#20
Ryszard Grenda, Piotr Kaliciński
Combined and sequential liver-kidney transplantation (CLKT and SLKT) is a definitive treatment in children with end-stage organ failure. There are two major indications: - terminal insufficiency of both organs, or - need for transplanting new liver as a source of lacking enzyme or specific regulator of the immune system in a patient with renal failure. A third (uncommon) option is secondary end-stage renal failure in liver transplant recipients. These three clinical settings use distinct qualification algorithms...
January 10, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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