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Organ donation

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https://www.readbyqxmd.com/read/28230644/expanding-the-donor-pool-through-intensive-care-to-facilitate-organ-donation-results-of-a-spanish-multicenter-study
#1
Beatriz Domínguez-Gil, Elisabeth Coll, José Elizalde, Jaime E Herrero, Teresa Pont, Brígida Quindós, Bella Marcelo, María A Bodí, Adolfo Martínez, Agustín Nebra, Francisco Guerrero, José M Manciño, Juan Galán, Miguel Lebrón, Eduardo Miñambres, Rafael Matesanz
BACKGROUND: Intensive Care to facilitate Organ Donation (ICOD) may help to increase the donor pool. We describe the Spanish experience with ICOD. METHODS: ACCORD-Spain consisted of an audit of the donation pathway from patients dead as a result of a devastating brain injury (possible donors) in 68 hospitals during 11/1/2014-4/30/2015. We focused on possible donors whose family was interviewed to discuss organ donation once intensive care with a therapeutic purpose was deemed futile and brain death (BD) was a likely outcome...
February 23, 2017: Transplantation
https://www.readbyqxmd.com/read/28229949/predicting-reactivity-of-model-dom-compounds-towards-chlorine-with-mediated-electrochemical-oxidation
#2
Glen Andrew de Vera, Wolfgang Gernjak, Jelena Radjenovic
Chlorine demand of a water sample depends on the characteristics of dissolved organic matter (DOM). It is an important parameter for water utilities used to assess oxidant and/or disinfectant consumption of source waters during treatment and distribution. In this study, model compounds namely resorcinol, tannic acid, vanillin, cysteine, tyrosine, and tryptophan were used to represent the reactive moieties of complex DOM mixtures. The reactivity of these compounds was evaluated in terms of Cl2 demand and electron donating capacity (EDC)...
January 23, 2017: Water Research
https://www.readbyqxmd.com/read/28229427/stem-cell-exosomes-cell-freetherapy-for-organ-repair
#3
Mohsin Khan, Raj Kishore
Cardiovascular disease is a significant cause of morbidity and mortality around the world. The damaged cardiac tissue is unable to repair itself following injury warranting the development of alternate therapies. Cell therapy has emerged recently as a viable treatment option resulting in significant improvement in cardiac function. Nevertheless, donated stem cells are hard to find in the heart after transplantation leading to the hypothesis that release of extracellular factors by stem cells is primarily responsible for the beneficial effect of cell therapy...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28228145/donation-after-brain-circulation-determination-of-death
#4
Anne L Dalle Ave, James L Bernat
BACKGROUND: The fundamental determinant of death in donation after circulatory determination of death is the cessation of brain circulation and function. We therefore propose the term donation after brain circulation determination of death [DBCDD]. RESULTS: In DBCDD, death is determined when the cessation of circulatory function is permanent but before it is irreversible, consistent with medical standards of death determination outside the context of organ donation...
February 23, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28224845/-i-love-transforming-services
#5
(no author information available yet)
With a background in critical and end of life care, Fiona Murphy has dedicated most of her 30-year nursing career to helping dying patients and their families. In 2002, she became donor liaison sister at Manchester's Royal Bolton Hospital, and her pioneering work in implementing a nurse-led bereavement and donation service saw her named Nursing Standard Nurse of the Year in 2011. She was awarded an MBE last year for services to nursing, bereavement services and organ donation, and is assistant director of nursing at Pennine Acute Hospitals NHS Trust...
February 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28221774/surface-electronic-state-modulated-single-crystalline-001-tio2-nanosheets-for-sensitive-electrochemical-sensing-of-heavy-metal-ions
#6
Wen-Yi Zhou, Jinyun Liu, Jieyao Song, Jinjin Li, Jinhuai Liu, Xing-Jiu Huang
Intrinsically low conductivity and poor reactivity restrict many semiconductors from electrochemical detection. Usually, metal- and carbon-based modifications of semiconductors are necessary, making them complex, expensive, and unstable. Here, for the first time, we present a surface-electronic-state-modulation-based concept applied to semiconductors. This concept enables pure semiconductors to be directly available for ultrasensitive electrochemical detection of heavy-metal ions without any modifications. As an example, a defective single-crystalline (001) TiO2 nanosheet exhibits high electrochemical performance toward Hg(II), including a sensitivity of 270...
February 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28219581/development-of-a-reliable-and-valid-organ-tissue-donation-and-transplantation-knowledge-scale
#7
G Ozturk Emiral, B Isıktekin Atalay, H Altunok, M E Gokler, M F Onsuz, S Metintas
INTRODUCTION: Knowledge has an important role in an individual's willingness to donate organs upon death. Knowledge enables clarification of false beliefs, which can increase willingness to consent to organ donation. The purpose of the study was to describe and examine the validity and reliability of the Organ-Tissue Donation and Transplantation Knowledge Scale (ODTKS). METHODS: We performed a comprehensive literature review and chose 23 items for the scale according to specialists' recommendations...
March 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28217596/distribution-of-abo-and-rh-types-in-voluntary-blood-donors-in-jharkhand-area-as-a-study-conducted-by-rims-ranchi
#8
Anu Singh, Ramesh Kumar Srivastava, Kabita S Deogharia, Kranti Kumar Singh
BACKGROUND: This study was done to know the distribution and frequencies of blood groups among blood donors attending voluntary blood donation camps organized by the Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand so that demand and supply ratio of the four blood groups can be maintained so that no patient dies due to lack of a particular blood group. CONTEXT: Up till now about 400 red cells antigen have been identified. The majority follow Mendelian inheritance...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28217590/partnerships-for-organizing-blood-donation-camp-an-experience-from-rural-north-india
#9
Shashi Kant, Sumit Malhotra, Farhad Ahamed, S Archana, Chandrakant S Pandav
BACKGROUND: Rural areas pose challenges for motivating villagers to donate blood. We organized a blood donation camp in a rural setting by engaging multiple stakeholders. We examined the factors that influenced blood donation. METHODS: Local level stakeholders were involved in planning of the camp. Mobilization of donors was attempted through intensive awareness generation activities utilizing multiple channels. A list of willing blood donors was prepared. RESULTS: Out of 152 willing donors, 88 reported to donation camp, and after screening, 67 donated the blood...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28216707/combined-liver-and-kidney-transplantation-our-experience-and-review-of-literature
#10
Kusuma Ramachandra Halemani, N Bhadrinath
Increased awareness of organ donation has increased the availability of deceased donors, and it has boosted the opportunities for treating patients with multiple organ dysfunction. Simultaneously replacing two organs gives advantages of single surgery, lower immunosuppression dose and better survival than when one organ alone is transplanted. We present reports of management of three cases of combined liver and kidney transplantation (CLKT) from deceased donors. Based on management of these cases we discuss the importance of CLKT and anaesthetic concerns during such complex procedures...
January 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28215133/use-of-imaging-studies-for-determination-of-brain-death-in-south-australian-intensive-care-units
#11
Brett G Sampson, Luke D Datson, Shailesh Bihari
OBJECTIVES: To describe the use of imaging studies (four-vessel angiography or radionuclide scan) for brain death determination in South Australian intensive care units, and to determine the rates of adherence with The ANZICS statement on death and organ donation of the Australian and New Zealand Intensive Care Society (ANZICS). DESIGN, PATIENTS AND SETTING: Retrospective case-note review of 190 South Australian adult patients (≥ 18 years) who were brain dead and were organ donors (actual and intended), from 1 January 2008 to 31 December 2014...
March 2017: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/28214180/a-successful-experience-of-the-iranian-blood-transfusion-organization-in-improving-accessibility-and-affordability-of-plasma-derived-medicine
#12
REVIEW
Azita Chegini, Seyed Ardeshir Torab, Ali Akbar Pourfatollah
Plasma is the liquid part of blood. It is estimated 21.6 million liters of plasma collect from Whole blood annually. From these plasma, 4.2 million liters transfuse, 8.1 million liters fractionate, 9.3 million liters waste. Nowadays, blood products and PDM (plasma derived medicine) consider as essential medicine in modern health care and transfusion medicine. Iranian blood transfusion organization as a non-profit organization was established in 1974 in order to centralize all blood transfusion activities from donor recruitment to distribution of blood components to hospitals...
January 4, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28212017/increased-electron-accepting-and-decreased-electron-donating-capacities-of-soil-humic-substances-in-response-to-increasing-temperature
#13
Wenbing Tan, Beidou Xi, Guoan Wang, Jie Jiang, Xiao-Song He, Xuhui Mao, Ru-Tai Gao, Cai-Hong Huang, Hui Zhang, Dan Li, Yufu Jia, Ying Yuan, Xinyu Zhao
The electron transfer capacities (ETC) of soil humic substances (HS) are linked to the type and abundance of redox-active functional moieties in their structure. Natural temperature can affect the chemical structure of natural organic matter by regulating their oxidative transformation and degradation in soils. However, it is unclear if there is a direct correlation between ETC of soil HS and mean annual temperature. In this study, we assess the response of the electron accepting and electron donating capacities (EAC and EDC) of soil HS to temperature by analyzing HS extracted from soil sets along glacial-interglacial cycles through loess-palaeosol sequences and along natural temperature gradients through latitude and altitude transects...
February 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28211142/a-stable-hexakis-guanidino-benzene-realization-of-the-strongest-neutral-organic-four-electron-donor
#14
Benjamin Eberle, Elisabeth Kaifer, Hans-Jörg Himmel
The growing demand for efficient batteries has stimulated the search for redox-active organic compounds with multistage redox behavior, as materials with large charge capacity. Herein we report the synthesis and properties of the first hexakis(guanidino)benzene derivative: a strong neutral organic electron donor with reversible multistage redox behavior and a record low redox potential for donation of four electrons. Detailed structural and spectroscopic characterization of three redox states (0, +2, and +4) reveal its unique electronic features...
February 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28209606/long-term-experiences-of-norwegian-live-kidney-donors-qualitative-in-depth-interviews
#15
Käthe B Meyer, Ida Torunn Bjørk, Astrid Klopstad Wahl, Annette Lennerling, Marit Helen Andersen
OBJECTIVE: Live kidney donation is generally viewed as a welcome treatment option for severe kidney disease. However, there is a disparity in the body of research on donor experiences and postdonation outcome, and lack of knowledge on long-term consequences described by the donors. This study was conducted to provide insight into donors' subjective meanings and interpretation of their experiences ∼10 years after donation. DESIGN: Qualitative explorative in-depth interviews...
February 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28207629/short-and-long-term-outcome-after-lung-transplantation-from-circulatory-dead-donors-a-single-center-experience
#16
David Ruttens, An Martens, Sofie Ordies, Stijn E Verleden, Arne P Neyrinck, Robin Vos, Marc Boada Collado, Bart M Vanaudenaerde, Geert M Verleden, Dirk Van Raemdonck
BACKGROUND: Donation after cardiac death (DCD) to overcome the donor organ shortage is well accepted in the clinical setting, although long-term outcome after DCD lung transplantation (LTx) remains largely unknown. METHODS: In this retrospective study, DCD LTx recipients (n=59) were compared with a cohort of donation after brain-death (DBD) LTx recipients (n=331) transplanted between February 2007 and September 2013; follow-up was until January 1st 2016. Short-term (duration of mechanical ventilation, ICU stay, hospital stay and highest PGD score within 72 hours) and long-term (CLAD-free and overall survival) follow-up were compared over a median follow-up of 50...
February 15, 2017: Transplantation
https://www.readbyqxmd.com/read/28197734/non-canonical-amino-acids-bearing-thiophene-and-bithiophene-synthesis-by-an-ugi-multicomponent-reaction-and-studies-on-ion-recognition-ability
#17
Cátia I C Esteves, M Manuela M Raposo, Susana P G Costa
Novel thienyl and bithienyl amino acids with different substituents were obtained by a multicomponent Ugi reaction between a heterocyclic aldehyde, an amine, an acid and an isocyanide. Due to the presence of the sulphur heterocycle at the side chain, these unnatural amino acids are highly emissive and bear extra electron donating atoms so they were tested for their ability to act as fluorescent probes and chemosensors in the recognition of biomedically relevant ions in acetonitrile and acetonitrile/water solutions...
February 14, 2017: Amino Acids
https://www.readbyqxmd.com/read/28197039/surgical-illustration-of-en-bloc-dual-kidney-transplant-from-a-16-month-old-brain-dead-donor-to-an-adult-recipient
#18
Vikas Jain, Saurabh Jain, Paras Singhal, Suman Lata Nayak, Rajendra P Mathur
Transplantable organs from pediatric donors have been contributing significantly to donor pool worldwide. Pediatric donors are excellent resources that should be procured whenever available, and with the recent increase in deceased donations in India, more pediatric donors will be available for organ harvesting. We share a rare instance of multi-organ harvesting from a 16-month old brain dead donor and implanting both kidneys en-bloc in an adult male, while liver went to a 4-year old child. The report provides the surgical illustration of salient steps of transplanting both kidneys from pediatric donor into an adult, in an en-bloc manner...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28196048/the-phs-increased-risk-label-is-associated-with-nonutilization-of-hundreds-of-organs-per-year
#19
Michael L Volk, Amber R Wilk, Cameron Wolfe, Daniel R Kaul
BACKGROUND: The Public Health Service "Increased Risk" (PHS IR) designation identifies donors at increased risk of transmitting hepatitis B, C, and human immunodeficiency virus. Although the risk remains very low in the era of nucleic acid testing, we hypothesized that this label may result in decreased organ utilization. METHODS: Organ Procurement and Transplantation Network (OPTN) data were used to compare utilization rates between PHS-IR and non-PHS-IR donors, as well as to compare export rates and variation in utilization...
February 11, 2017: Transplantation
https://www.readbyqxmd.com/read/28195535/the-unfair-trade-why-organ-sale-is-indefensible
#20
Siby K George
This paper argues against the proposal of a system of compensated living donation in the global south, especially India, without recourse to essentialist ethics. It relies on the anti-essentialist ethical-ontology of Levinas for the claim that it is the concrete vulnerability of the suffering other, rather than any absolute moral imperative, that makes a market for organs unethical.
January 4, 2017: Indian Journal of Medical Ethics
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