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https://www.readbyqxmd.com/read/28937950/vectors-and-gene-delivery-to-the-retina
#1
Arthur Planul, Deniz Dalkara
One of the great advantages of the retina as a target tissue for gene delivery is the wide array of genetic tools that have been developed in the past decade. This includes a variety of vectors for therapeutic gene delivery to most types of retinal neurons and glia, as well as cell type-specific promoters for restricted gene expression in distinct neuronal subtypes. Within the scope of neuroscience applications and for gene therapy, it is now routine to express reporter genes, replacement genes, neuronal activity indicators, and microbial opsins in specific neuronal types in the mouse retina...
September 15, 2017: Annual Review of Vision Science
https://www.readbyqxmd.com/read/28937343/effaced-enigmata
#2
Grant Gillett
Severe head injury or brain injury presents clinical neuroscientists with a unique challenge. Based on an objective assessment of cognitive and neurological function, it is sometimes hard to recognize our patients as members of our moral community (actually or potentially) but we treat them as if that were is the case, and, therefore, as if they need rescuing. Thus their existences as enigmata-beings who may or may not reveal themselves to us through social and personal function realized in conversations and relationships-are in doubt...
October 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28937340/research-domain-criteria-as-psychiatric-nosology
#3
Faisal Akram, James Giordano
Diagnostic classification systems in psychiatry have continued to rely on clinical phenomenology, despite limitations inherent in that approach. In view of these limitations and recent progress in neuroscience, the National Institute of Mental Health (NIMH) has initiated the Research Domain Criteria (RDoC) project to develop a more neuroscientifically based system of characterizing and classifying psychiatric disorders. The RDoC initiative aims to transform psychiatry into an integrative science of psychopathology in which mental illnesses will be defined as involving putative dysfunctions in neural nodes and networks...
October 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28937337/ethical-and-legal-implications-of-the-methodological-crisis-in-neuroimaging
#4
Philipp Kellmeyer
Currently, many scientific fields such as psychology or biomedicine face a methodological crisis concerning the reproducibility, replicability, and validity of their research. In neuroimaging, similar methodological concerns have taken hold of the field, and researchers are working frantically toward finding solutions for the methodological problems specific to neuroimaging. This article examines some ethical and legal implications of this methodological crisis in neuroimaging. With respect to ethical challenges, the article discusses the impact of flawed methods in neuroimaging research in cognitive and clinical neuroscience, particularly with respect to faulty brain-based models of human cognition, behavior, and personality...
October 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28936231/promoting-healthy-child-development-via-a-two-generation-translational-neuroscience-framework-the-filming-interactions-to-nurture-development-video-coaching-program
#5
Philip A Fisher, Tahl I Frenkel, Laura K Noll, Melanie Berry, Melissa Yockelson
In this article, we focus on applying methods of translational neuroscience to two-generation, family-based interventions. In recent years, a small but growing body of evidence has documented the reversibility of some of the neurobiological effects of early adversity in the context of environmental early interventions. Some of these interventions are now being implemented at scale, which may help reduce disparities in the face of early life stress. Further progress may occur by extending these efforts to two-generation models that target caregivers' capabilities to improve children's outcomes...
December 2016: Child Development Perspectives
https://www.readbyqxmd.com/read/28933871/neuropsychology-and-cognitive-neuroscience-in-the-fmri-era-a-recapitulation-of-localizationist-and-connectionist-views
#6
Matthew J Sutterer, Daniel Tranel
OBJECTIVE: We highlight the past 25 years of cognitive neuroscience and neuropsychology, focusing on the impact to the field of the introduction in 1992 of functional MRI (fMRI). METHOD: We reviewed the past 25 years of literature in cognitive neuroscience and neuropsychology, focusing on the relation and interplay of fMRI studies and studies utilizing the "lesion method" in human participants with focal brain damage. RESULTS: Our review highlights the state of localist/connectionist research debates in cognitive neuroscience and neuropsychology circa 1992, and details how the introduction of fMRI into the field at that time catalyzed a new wave of efforts to map complex human behavior to specific brain regions...
September 21, 2017: Neuropsychology
https://www.readbyqxmd.com/read/28932809/aberrant-cortical-activity-in-multiple-gcamp6-expressing-transgenic-mouse-lines
#7
Nicholas A Steinmetz, Christina Buetfering, Jerome Lecoq, Christian R Lee, Andrew J Peters, Elina A K Jacobs, Philip Coen, Douglas R Ollerenshaw, Matthew T Valley, Saskia E J de Vries, Marina Garrett, Jun Zhuang, Peter A Groblewski, Sahar Manavi, Jesse Miles, Casey White, Eric Lee, Fiona Griffin, Joshua D Larkin, Kate Roll, Sissy Cross, Thuyanh V Nguyen, Rachael Larsen, Julie Pendergraft, Tanya Daigle, Bosiljka Tasic, Carol L Thompson, Jack Waters, Shawn Olsen, David J Margolis, Hongkui Zeng, Michael Hausser, Matteo Carandini, Kenneth D Harris
Transgenic mouse lines are invaluable tools for neuroscience but, as with any technique, care must be taken to ensure that the tool itself does not unduly affect the system under study. Here we report aberrant electrical activity, similar to interictal spikes, and accompanying fluorescence events in some genotypes of transgenic mice expressing GCaMP6 genetically encoded calcium sensors. These epileptiform events have been observed particularly, but not exclusively, in mice with Emx1-Cre and Ai93 transgenes, of either sex, across multiple laboratories...
September 2017: ENeuro
https://www.readbyqxmd.com/read/28928071/a-behavioral-and-cognitive-neuroscience-perspective-on-impulsivity-suicide-and-non-suicidal-self-injury-meta-analysis-and-recommendations-for-future-research
#8
REVIEW
Richard T Liu, Zoë M Trout, Evelyn M Hernandez, Shayna M Cheek, Nimesha Gerlus
We conducted a meta-analysis of neurobehavioral and neurocognitive indices of impulsivity in relation to suicidal thoughts and behaviors, as well as non-suicidal self-injury (NSSI). In our systematic review, 34 studies were identified and submitted to a random-effects meta-analysis. A small pooled effect size was observed for the association between behavioral impulsivity and NSSI (OR=1.34, p<0.05). A small-to-medium pooled effect size (OR=2.23, p<0.001) was found for the association between behavioral impulsivity and suicide attempts, and a medium-to-large pooled effect size was observed for this outcome in relation to cognitive impulsivity (OR=3...
September 16, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28928027/development-of-a-sexual-needs-rehabilitation-framework-in-women-post-spinal-cord-injury-a-study-from-iran
#9
Raziyeh Maasoumi, Fatemeh Zarei, Effat Merghati-Khoei, Taylor Lawson, Seyyed Hasan Emami-Razavi
OBJECTIVE: To develop a sexual needs rehabilitation framework in women post spinal cord injury (SCI) DESIGN: Mixed-methods study SETTING: Brain and Spinal Cord Injury Research Center (BASIR), Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran PARTICIPANTS: Married women with at least one year passed injury INTERVENTION: Not applicable METHODS: This study was designed in three steps; primary needs assessment with quantitative and qualitative methods, prioritizing identified needs by expert panels, and developing framework...
September 16, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28927509/health-care-workers-experiences-of-aggression
#10
Katelyn Kerr, Joanne Oram, Helen Tinson, David Shum
PRIMARY OBJECTIVE: To identify the prevalence of patient aggression against health care workers, the consequences and coping mechanisms. DESIGN: Retrospective cross-sectional design. SUBJECTS: 50 participants comprised 37 nurses, 1 ward staff, 12 allied health staff employed in two brain injury wards with experience ranging from 3months to 34years. SETTING: Neurosciences and Brain Injury Rehabilitation wards of a metropolitan tertiary hospital in Brisbane...
October 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28927278/call-for-papers-dark-classics-in-chemical-neuroscience
#11
Craig W Lindsley
No abstract text is available yet for this article.
September 20, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28926765/texture-and-art-with-deep-neural-networks
#12
REVIEW
Leon A Gatys, Alexander S Ecker, Matthias Bethge
Although the study of biological vision and computer vision attempt to understand powerful visual information processing from different angles, they have a long history of informing each other. Recent advances in texture synthesis that were motivated by visual neuroscience have led to a substantial advance in image synthesis and manipulation in computer vision using convolutional neural networks (CNNs). Here, we review these recent advances and discuss how they can in turn inspire new research in visual perception and computational neuroscience...
September 16, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28925886/the-microbiota-gut-brain-axis-in-neuropsychiatric-disorders-pathophysiological-mechanisms-and-novel-treatments
#13
Yong-Ku Kim, Cheolmin Shin
BACKGROUND: The human gut microbiome comprise a huge number of microorganisms with co-evolutionary associations with humans. It has been repeatedly revealed that bidirectional communication exists between the brain and the gut and involves neural, hormonal, and immunological pathways. Evidences from neuroscience researches over the past few years suggest that microbiota is essential for the development and maturation of brain systems that are associated to stress responses. METHOD: This review provides that the summarization of the communication among microbiota, gut and brain and the results of preclinical and clinical studies on gut microbiota used in treatments for neuropsychiatric disorders...
September 15, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28924628/a-recurrent-neural-model-for-proto-object-based-contour-integration-and-figure-ground-segregation
#14
Brian Hu, Ernst Niebur
Visual processing of objects makes use of both feedforward and feedback streams of information. However, the nature of feedback signals is largely unknown, as is the identity of the neuronal populations in lower visual areas that receive them. Here, we develop a recurrent neural model to address these questions in the context of contour integration and figure-ground segregation. A key feature of our model is the use of grouping neurons whose activity represents tentative objects ("proto-objects") based on the integration of local feature information...
September 19, 2017: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/28924257/electrodiffusion-phenomena-in-neuroscience-a-neglected-companion
#15
REVIEW
Leonid P Savtchenko, Mu Ming Poo, Dmitri A Rusakov
The emerging technological revolution in genetically encoded molecular sensors and super-resolution imaging provides neuroscientists with a pass to the real-time nano-world. On this small scale, however, classical principles of electrophysiology do not always apply. This is in large part because the nanoscopic heterogeneities in ionic concentrations and the local electric fields associated with individual ions and their movement can no longer be ignored. Here, we review basic principles of molecular electrodiffusion in the cellular environment of organized brain tissue...
September 19, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28923240/national-survey-on-perioperative-anaesthetic-management-in-the-endovascular-treatment-of-acute-ischaemic-stroke
#16
O Romero Kräuchi, L Valencia, F Iturri, A Mariscal Ortega, A López Gómez, R Valero
OBJECTIVE: To assess the anaesthetic management of treatment for endovascular acute ischaemic stroke (AIS) in Spain. MATERIALS AND METHOD: A survey was designed by the SEDAR Neuroscience Section and sent to the Spanish anaesthesiology departments with a primary stroke centre between July and November 2016. RESULTS: Of the 47 hospitals where endovascular treatment of AIS is performed, 37 anaesthesiology departments participated. Thirty responses were obtained; three of which were eliminated due to duplication (response rate of 72...
September 15, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28922520/a-review-of-joint-attention-and-social-cognitive-brain-systems-in-typical-development-and-autism-spectrum-disorder
#17
Peter Mundy
This article provides a review of the increasingly detailed literature on the neurodevelopment of joint attention. Many findings from this literature support and inform the hypothesis that the neurodevelopment of joint attention contributes to the functional development of neural systems for human social cognition. Joint attention begins to develop by 5 months of age and is tantamount to the ability to adopt a common perspective with another person. It involves a whole-brain system with nodes in the: (a) dorsal and medial frontal cortex, (b) orbital frontal/insula cortex, (c) anterior/ posterior cingulate cortex, (d) superior temporal cortex, (e) precuneus/parietal cortex, and (f) amygdala and striatum...
September 18, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28920892/computationally-efficient-algorithms-for-sparse-dynamic-solutions-to-the-eeg-source-localization-problem
#18
Elvira Pirondini, Behtash Babadi, Gabriel Obregon-Henao, Camilo Lamus, Wasim Q Malik, Matti S Hamalainen, Patrick L Purdon
OBJECTIVE: Electroencephalography (EEG) and magnetoencephalography (MEG) non-invasively record scalp electromagnetic fields generated by cerebral currents, revealing millisecond-level brain dynamics useful for neuroscience and clinical applications. Estimating the currents that generate these fields, i.e., source localization, is an ill-conditioned inverse problem. Solutions to this problem have focused on spatial continuity constraints, dynamic modeling, or sparsity constraints. The combination of these key ideas could offer significant performance improvements, but substantial computational costs pose a challenge for practical application of such approaches...
September 14, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28920067/a-history-of-dystonia-ancient-to-modern
#19
REVIEW
Rachel E Newby, Deborah E Thorpe, Peter A Kempster, Jane E Alty
Before 1911, when Hermann Oppenheim introduced the term dystonia, this movement disorder lacked a unifying descriptor. While words like epilepsy, apoplexy, and palsy have had their meanings since antiquity, references to dystonia are much harder to identify in historical documents. Torticollis is an exception, although there is difficulty distinguishing dystonic torticollis from congenital muscular torticollis. There are, nevertheless, possible representations of dystonia in literature and visual art from the pre-modern world...
July 2017: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/28919862/changes-in-dimensionality-and-fractal-scaling-suggest-soft-assembled-dynamics-in-human-eeg
#20
Travis J Wiltshire, Matthew J Euler, Ty L McKinney, Jonathan E Butner
Humans are high-dimensional, complex systems consisting of many components that must coordinate in order to perform even the simplest of activities. Many behavioral studies, especially in the movement sciences, have advanced the notion of soft-assembly to describe how systems with many components coordinate to perform specific functions while also exhibiting the potential to re-structure and then perform other functions as task demands change. Consistent with this notion, within cognitive neuroscience it is increasingly accepted that the brain flexibly coordinates the networks needed to cope with changing task demands...
2017: Frontiers in Physiology
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