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https://www.readbyqxmd.com/read/28234899/on-the-stability-and-dynamics-of-stochastic-spiking-neuron-models-nonlinear-hawkes-process-and-point-process-glms
#1
Felipe Gerhard, Moritz Deger, Wilson Truccolo
Point process generalized linear models (PP-GLMs) provide an important statistical framework for modeling spiking activity in single-neurons and neuronal networks. Stochastic stability is essential when sampling from these models, as done in computational neuroscience to analyze statistical properties of neuronal dynamics and in neuro-engineering to implement closed-loop applications. Here we show, however, that despite passing common goodness-of-fit tests, PP-GLMs estimated from data are often unstable, leading to divergent firing rates...
February 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28234784/editorial-neuroscience
#2
Raimund Helbok
No abstract text is available yet for this article.
February 23, 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28233379/optogenetics-applications-in-psychiatric-research
#3
Fukutoshi Shirai, Akiko Hayashi-Takagi
Recently, optogenetic techniques emerged as a method to optically manipulate molecular and cellular events in target cells both in vitro and in vivo. Optogenetics result from the fruitful combination of optics and genetic engineering, maximizing the advantages of each discipline. These advantages are optical control through the manipulation of wavelength and light intensity on the millisecond time scale, and specific gene expression and gene product trafficking with subcellular precision. This kind of fine-tuning cannot be achieved using traditional methods...
February 24, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28232815/to-increase-our-knowledge-on-sleep-sleep-disorders-and-chronobiology-in-the-neuroscience-field-during-the-next-decade
#4
EDITORIAL
Yves Dauvilliers
No abstract text is available yet for this article.
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28232785/enhancing-the-activity-of-the-dlpfc-with-tdcs-alters-risk-preference-without-changing-interpersonal-trust
#5
Haoli Zheng, Siqi Wang, Wenmin Guo, Shu Chen, Jun Luo, Hang Ye, Daqiang Huang
Interpersonal trust plays an essential role in economic interactions and social development. Extensive behavioral experiments have examined the nature of trust, particularly the question of whether trusting decisions are connected to risk preferences or risk attitudes. Various laboratory observations have been reported regarding the difference between trust and risk, and neural imaging studies have demonstrated that the right dorsolateral prefrontal cortex (rDLPFC) is more activated when individuals decide to trust other human beings compared with individuals decide to invest in a non-social risk condition...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28232356/books-biosemiotic-medicine-healing-in-the-world-of-meaning-studies-in-neuroscience-consciousness-and-spirituality-a-paradigm-shift-in-biology
#6
Gerald W Partridge
No abstract text is available yet for this article.
March 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28232050/prosody-in-birdsong-a-review-and-perspective
#7
REVIEW
Carien Mol, Aoju Chen, René Kager, Sita M Ter Haar
MOL, C., Chen, A., Kager, R., ter Haar, S.M. Prosody in birdsong: A review and perspective. NEUROSCI BIOBEHAV REV XX(X) XXX-XXX, XXXX. - Birdsong shows striking parallels with human speech. Previous comparisons between birdsong and human vocalizations focused on syntax, phonology and phonetics. In this review, we propose that future comparative research should expand its focus to include prosody, i.e. the temporal and melodic properties that extend over larger units of song. To this end, we consider the similarities between birdsong structure and the prosodic hierarchy in human speech and between context-dependent acoustic variations in birdsong and the biological codes in human speech...
February 19, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28231461/tips-for-young-scientists-on-the-junior-faculty-independent-investigator-job-search
#8
Kelsey C Martin
Landing a job as an assistant professor or independent investigator in neuroscience in an academic institution or research institute depends on the accomplishments young scientists make during years of training as graduate students and postdoctoral fellows. This training prepares scientists for an array of exciting job opportunities, one of which is as a faculty member or independent investigator. My goal in this NeuroView is to provide tips about the job search for young scientists who have decided to enter the junior faculty/independent investigator job market...
February 22, 2017: Neuron
https://www.readbyqxmd.com/read/28230848/computational-approaches-to-fmri-analysis
#9
Jonathan D Cohen, Nathaniel Daw, Barbara Engelhardt, Uri Hasson, Kai Li, Yael Niv, Kenneth A Norman, Jonathan Pillow, Peter J Ramadge, Nicholas B Turk-Browne, Theodore L Willke
Analysis methods in cognitive neuroscience have not always matched the richness of fMRI data. Early methods focused on estimating neural activity within individual voxels or regions, averaged over trials or blocks and modeled separately in each participant. This approach mostly neglected the distributed nature of neural representations over voxels, the continuous dynamics of neural activity during tasks, the statistical benefits of performing joint inference over multiple participants and the value of using predictive models to constrain analysis...
February 23, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28230847/building-better-biomarkers-brain-models-in-translational-neuroimaging
#10
REVIEW
Choong-Wan Woo, Luke J Chang, Martin A Lindquist, Tor D Wager
Despite its great promise, neuroimaging has yet to substantially impact clinical practice and public health. However, a developing synergy between emerging analysis techniques and data-sharing initiatives has the potential to transform the role of neuroimaging in clinical applications. We review the state of translational neuroimaging and outline an approach to developing brain signatures that can be shared, tested in multiple contexts and applied in clinical settings. The approach rests on three pillars: (i) the use of multivariate pattern-recognition techniques to develop brain signatures for clinical outcomes and relevant mental processes; (ii) assessment and optimization of their diagnostic value; and (iii) a program of broad exploration followed by increasingly rigorous assessment of generalizability across samples, research contexts and populations...
February 23, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28230844/network-neuroscience
#11
REVIEW
Danielle S Bassett, Olaf Sporns
Despite substantial recent progress, our understanding of the principles and mechanisms underlying complex brain function and cognition remains incomplete. Network neuroscience proposes to tackle these enduring challenges. Approaching brain structure and function from an explicitly integrative perspective, network neuroscience pursues new ways to map, record, analyze and model the elements and interactions of neurobiological systems. Two parallel trends drive the approach: the availability of new empirical tools to create comprehensive maps and record dynamic patterns among molecules, neurons, brain areas and social systems; and the theoretical framework and computational tools of modern network science...
February 23, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28230841/magnetoencephalography-for-brain-electrophysiology-and-imaging
#12
REVIEW
Sylvain Baillet
We review the aspects that uniquely characterize magnetoencephalography (MEG) among the techniques available to explore and resolve brain function and dysfunction. While emphasizing its specific strengths in terms of millisecond source imaging, we also identify and discuss current practical challenges, in particular in signal extraction and interpretation. We also take issue with some perceived disadvantages of MEG, including the misconception that the technique is redundant with electroencephalography. Overall, MEG contributes uniquely to our deeper comprehension of both regional and large-scale brain dynamics: from the functions of neural oscillations and the nature of event-related brain activation, to the mechanisms of functional connectivity between regions and the emergence of modes of network communication in brain systems...
February 23, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28229395/transcranial-magnetic-and-direct-current-stimulation-in-children
#13
REVIEW
Mustafa Q Hameed, Sameer C Dhamne, Roman Gersner, Harper L Kaye, Lindsay M Oberman, Alvaro Pascual-Leone, Alexander Rotenberg
Promising results in adult neurologic and psychiatric disorders are driving active research into transcranial brain stimulation techniques, particularly transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), in childhood and adolescent syndromes. TMS has realistic utility as an experimental tool tested in a range of pediatric neuropathologies such as perinatal stroke, depression, Tourette syndrome, and autism spectrum disorder (ASD). tDCS has also been tested as a treatment for a number of pediatric neurologic conditions, including ASD, attention-deficit/hyperactivity disorder, epilepsy, and cerebral palsy...
February 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28228565/a-dedicated-scholarly-research-program-in-an-adult-and-pediatric-neurology-residency-program
#14
Matthew S Robbins, Sheryl R Haut, Richard B Lipton, Mark J Milstein, Lenore C Ocava, Karen Ballaban-Gil, Solomon L Moshé, Mark F Mehler
OBJECTIVE: To describe and assess the effectiveness of a formal scholarly activity program for a highly integrated adult and pediatric neurology residency program. METHODS: Starting in 2011, all graduating residents were required to complete at least one form of scholarly activity broadly defined to include peer-reviewed publications or presentations at scientific meetings of formally mentored projects. The scholarly activity program was administered by the associate residency training director and included an expanded journal club, guided mentorship, a required grand rounds platform presentation, and annual awards for the most scholarly and seminal research findings...
February 22, 2017: Neurology
https://www.readbyqxmd.com/read/28228081/the-neurobiology-and-psychiatric-perspective-of-vaginismus-linking-the-pharmacological-and-psycho-social-interventions
#15
Zuri Shahidii Kadir, Hatta Sidi, Jaya Kumar, Srijit Das, Marhani Midin, Najwa Baharuddin
Vaginismus is an involuntary muscle contraction of the outer third of vaginal barrel causing sexual penetration almost impossible. It is generally classified under sexual pain disorder (SPD). In Diagnostic and Statistical Manual, 5th edition, it is classified under the new rubric of Genito-Pelvic Pain/Sexual Penetration Disorder. This fear-avoidance condition poses an ongoing significant challenge to the medical and health professionals due to the very demanding needs in health care despite its unpredictable prognosis...
February 22, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28227923/a-sapphire-based-monolithic-integrated-optrode
#16
He Zhang, Weihua Pei, Xiaowei Yang, Xuhong Guo, Xiao Xing, Ruicong Liu, Yuanyuan Liu, Qiang Gui, Hongda Chen, He Zhang, Weihua Pei, Xiaowei Yang, Xuhong Guo, Xiao Xing, Ruicong Liu, Yuanyuan Liu, Qiang Gui, Hongda Chen, Xuhong Guo, Hongda Chen, Weihua Pei, Yuanyuan Liu, Ruicong Liu, Xiaowei Yang, He Zhang, Qiang Gui, Xiao Xing
A novel kind of optrode fabricated on a sapphire substrate is proposed for optogenetic applications in neuroscience. Eight thin-film neural electrodes and a GaN-LED are monolithically integrated on the surface of a sapphire shank. The LED is used for optogenetic stimulation and the multiple electrodes are used for simultaneous recording of neural activities. The output power density of the LED is 1-19 mW/mm(2) at 468 nm, driving with a current from 0.7-10 mA. The mean electrochemical impedance of the eight recoding sites on the optrode at 1 kHz is 385 kΩ...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227862/effects-of-high-frequency-rtms-on-sleep-deprivation-a-pilot-study
#17
D P Martinez-Cancino, J Azpiroz-Leehan, L Jimenez-Angeles, A Garcia-Quintanar, R Santana-Miranda, D P Martinez-Cancino, J Azpiroz-Leehan, L Jimenez-Angeles, A Garcia-Quintanar, R Santana-Miranda, A Garcia-Quintanar, L Jimenez-Angeles, R Santana-Miranda, J Azpiroz-Leehan, D P Martinez-Cancino
Transcranial magnetic stimulation is a neurostimulation technique which has the potential to serve as a unique research tool for investigating a wide variety of fields in cognitive neuroscience. TMS has been approved by the FDA to serve as a treatment to depression and has also been used to evaluate its effects among several conditions such as Alzheimer, Parkinson disease, chronic pain and stroke. High frequency TMS has been previously used with the intention to measure and modulate the negative effects of sleep deprivation in cognitive performance, but there is no consensus about the ideal protocol yet...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227847/a-compact-representation-for-the-auditory-full-range-response-and-its-fast-denoising-using-an-image-filter-based-on-the-radon-transform
#18
Manuel C Kohl, Daniel J Strauss, Manuel C Kohl, Daniel J Strauss, Daniel J Strauss, Manuel C Kohl
The Auditory Brainstem, Middle-Latency and Late Responses, a class of event-related potentials (ERPs), are of considerable interest in neuroscience research as robust neural correlates of different processing stages along the auditory pathway. While most research to date centers around one of the responses at a time for practical reasons, recent efforts indicate a paradigm shift towards acquiring them together, enabling the simultaneous monitoring of all auditory processing stages from the brainstem to the cortex...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227805/modular-multipin-electrodes-for-comfortable-dry-eeg
#19
P Fiedler, D Strohmeier, A Hunold, S Griebel, R Muhle, M Schreiber, P Pedrosa, B Vasconcelos, C Fonseca, F Vaz, J Haueisen, P Fiedler, D Strohmeier, A Hunold, S Griebel, R Muhle, M Schreiber, P Pedrosa, B Vasconcelos, C Fonseca, F Vaz, J Haueisen, P Pedrosa, F Vaz, P Fiedler, B Vasconcelos, J Haueisen, M Schreiber, R Muhle, C Fonseca, S Griebel, D Strohmeier, A Hunold
Electrode and cap concepts for continuous and ubiquitous monitoring of brain activity will open up new fields of application and contribute to increased use of electroencephalography (EEG) in clinical routine, neurosciences, brain-computer-interfacing and out-of-the-lab monitoring. However, mobile and unobtrusive applications are currently hindered by the lack of applicable convenient and reliable electrode and cap systems. We propose a novel modular electrode concept based on a flexible polymer substrate, coated with electrically conductive metallic films...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227751/a-time-domain-frequency-selective-multivariate-granger-causality-approach
#20
Lutz Leistritz, Herbert Witte, Lutz Leistritz, Herbert Witte, Lutz Leistritz, Herbert Witte
The investigation of effective connectivity is one of the major topics in computational neuroscience to understand the interaction between spatially distributed neuronal units of the brain. Thus, a wide variety of methods has been developed during the last decades to investigate functional and effective connectivity in multivariate systems. Their spectrum ranges from model-based to model-free approaches with a clear separation into time and frequency range methods. We present in this simulation study a novel time domain approach based on Granger's principle of predictability, which allows frequency-selective considerations of directed interactions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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