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https://www.readbyqxmd.com/read/29789142/diffuse-idiopathic-pulmonary-neuroendocrine-cell-hyperplasia-report-of-two-cases
#1
Eva García-Fontán, Montserrat Blanco Ramos, Jose Soro García, Rommel Carrasco, Miguel Ángel Cañizares, Ana González Piñeiro
INTRODUCTION: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare disorder characterized by a proliferation of neuroendocrine cells within the lung. It is classically described as a disease with persistent cough, dyspnea and wheezing in non-smoker middle aged females. CT of the chest reveals diffuse air trapping with mosaic pattern. PATIENTS AND METHODS: We present two cases of DIPNECH that were sent to our department to perform a lung biopsy with the diagnostic suspicion of diffuse interstitial disease...
May 19, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29788907/mycobacterium-avium-complex-vertebral-osteomyelitis-in-the-absence-of-hiv-infection-a-case-report-and-review
#2
Megan E Gray, Peter W Liu, Brian Wispelwey
BACKGROUND: Mycobacterium Avium Complex (MAC) is an established microbiologic cause of pulmonary disease, lymphadenitis, and disseminated disease in cases of advanced immune suppression. However, MAC manifesting as vertebral osteomyelitis is less common, and is particularly rare in the absence of Acquired Immunodeficiency Syndrome (AIDS). Prompt diagnosis of MAC vertebral osteomyelitis is challenging, but necessary to prevent serious morbidity or mortality. CASE PRESENTATION: We report a case of MAC osteomyelitis of the lumbar spine in a 70-year-old woman on extended duration corticosteroid therapy for systemic lupus erythematosus who presented with progressive back pain...
May 22, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29787590/cost-effectiveness-of-an-autoantibody-test-earlycdt-lung-as-an-aid-to-early-diagnosis-of-lung-cancer-in-patients-with-incidentally-detected-pulmonary-nodules
#3
John Edelsberg, Derek Weycker, Mark Atwood, Geoffrey Hamilton-Fairley, James R Jett
OBJECTIVE: Patients who have incidentally detected pulmonary nodules and an estimated intermediate risk (5-60%) of lung cancer frequently are followed via computed tomography (CT) surveillance to detect nodule growth, despite guidelines for a more aggressive diagnostic strategy. We examined the cost-effectiveness of an autoantibody test (AABT)-Early Cancer Detection Test-Lung (EarlyCDT-LungTM)-as an aid to early diagnosis of lung cancer among such patients. METHODS: We developed a decision-analytic model to evaluate use of the AABT versus CT surveillance alone...
2018: PloS One
https://www.readbyqxmd.com/read/29785389/pelvic-and-pulmonary-benign-metastasizing-leiomyoma-a-case-report
#4
Jennifer B Bakkensen, Wesley Samore, Pietro Bortoletto, Cynthia C Morton, Raymond M Anchan
Seven years after she had a total abdominal hysterectomy for benign leiomyomas, a 46-year-old woman presented with a pelvic mass and multiple pulmonary nodules. She underwent resection of the mass and core needle biopsy of a pulmonary lesion. Histopathologic analysis revealed that both the pelvic and the pulmonary lesions were consistent with benign leiomyomas. Benign metastasizing leiomyoma should be considered if a woman of reproductive age and with a history of leiomyomas presents with extrauterine nodules without evidence of malignancy...
April 2018: Case Reports in Women's Health
https://www.readbyqxmd.com/read/29785303/ocular-manifestations-of-biopsy-proven-pulmonary-sarcoidosis-in-korea
#5
Seung Yong Choi, Jae Hoon Lee, Jae-Yon Won, Jeong Ah Shin, Young-Hoon Park
Purpose: To investigate the clinical features and ocular manifestations of biopsy-proven pulmonary sarcoidosis in Korea. Methods: 55 patients diagnosed with pulmonary sarcoidosis by bronchoscopic or excisional biopsy were included. By retrospective clinical chart review, we investigated features of uveitis, ocular and systemic treatments, visual acuity, angiotensin-converting enzyme level, chest radiography, and pulmonary function tests. Clinical features were analyzed by presence of uveitis, site of biopsy, and first manifested sign of sarcoidosis...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29785020/glypican-1-immunohistochemistry-does-not-separate-mesothelioma-from-pulmonary-adenocarcinoma
#6
Kenrry Chiu, Lawrence Lee, Simon Cheung, Andrew M Churg
Immunohistochemistry (IHC) is used to help differentiate pleural mesothelioma from pulmonary adenocarcinoma in pleural biopsies and cytology specimens of pleural effusions due to overlapping morphologic features between these two malignancies. The aim of this study is to evaluate IHC glypican-1, a recently proposed marker for epithelioid mesothelioma, in our cohort of mesotheliomas and pulmonary adenocarcinoma. Tissue microarrays with duplicate cores from 33 cases of mesotheliomas (28 epithelioid type and five sarcomatoid type) and 21 cases of pulmonary adenocarcinoma were stained with glypican-1 antibody...
May 21, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29780637/recent-developments-in-minimally-invasive-surgery-for-biopsy-of-small-pulmonary-nodules
#7
REVIEW
Long Jiang, Jianxing He
Following the development of radiological technology, there has been an increase in the number of pulmonary nodules found. The management of pulmonary nodules represents a specific challenge to thoracic surgeons. Pulmonary nodules are small, focal, rounded radiographic opacities that may be solitary or multiple. The definite histopathologic diagnosis is crucial in determining management ranging from interval imaging to surgical resection. The choice of a particular biopsy technique depends on the risks/benefits of the procedure, the diagnostic yield, and local expertise...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29780632/management-pathways-for-solitary-pulmonary-nodules
#8
REVIEW
Masaoki Ito, Yoshihiro Miyata, Morihito Okada
Pulmonary nodules are often detected during the clinical course of several diseases or through routine screening. Various guidelines have proposed management algorithms for suspicious solitary nodules in lung cancer. Generally, solitary pulmonary nodules are managed according to nodule appearance and risk of lung cancer using low-dose, thin section computed tomography (CT). Liquid biopsy is promising for diagnosis, therapeutic-monitoring and follow-up in lung cancer; however, diagnosis and management pathways based on genetic examination alone have not been established...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29780127/a-case-of-transient-pulmonary-interstitial-lesions-in-aquaporin-4-positive-neuromyelitis-optica-spectrum-disorder
#9
Yuko Asato, Toshiaki Kamitani, Kuniyuki Ootsuka, Mizuki Kuramochi, Kozo Nakanishi, Tetsuya Shimada, Toshiyuki Takahashi, Tatsuro Misu, Masashi Aoki, Kazuo Fujihara, Yoshinori Kawabata
We herein report the case of a 76-year old man with aquaporin-4-Immunoglobulin-G (AQP4-IgG)-positive neuromyelitis optica spectrum disorder (NMOSD), in whom transient interstitial pulmonary lesions developed at the early stage of the disease. Chest X-ray showed multiple infiltrative shadows in both upper lung fields, and computed tomography revealed abnormal shadows distributed randomly in the lungs. Surgical lung biopsy showed features of unclassifiable interstitial pneumonia, characterized by various types of air-space organization, which resulted in obscure lung structure...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29780119/a-rare-case-of-isolated-chronic-cough-caused-by-pulmonary-lymphangitic-carcinomatosis-as-a-primary-manifestation-of-rectum-carcinoma
#10
Minami Okayama, Yoshihiro Kanemitsu, Tetsuya Oguri, Takamitsu Asano, Satoshi Fukuda, Hirotsugu Ohkubo, Masaya Takemura, Ken Maeno, Yutaka Ito, Akio Niimi
A 36-year old man was referred to our hospital due to isolated chronic cough that was refractory to anti-asthma medications, including inhaled corticosteroids/long-acting β2 agonists. Chest X-ray showed diffuse nodular and enhanced vascular shadows with Kerley lines in both lungs. A blood analysis showed elevated serum CEA and CA19-9 levels. A transbronchial biopsy revealed well to moderately differentiated adenocarcinoma, the origin of which was immunohistochemically suspected to be the gastrointestinal tract...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29778999/idiopathic-nodular-glomerulosclerosis-ing-in-an-african-american-aa-man-with-hepatitis-c
#11
Nirmal K Onteddu, Jayasri Duggirala, Anand C Reddy
Idiopathic nodular glomerulosclerosis (ING) in a non-diabetic patient is uncommon. Nodular glomerulosclerosis is hallmark sign of diabetic nephropathy. ING is a very rare clinicopathological disease associated with smoking, obesity and hypertension, chronic obstructive pulmonary disease and metabolic syndrome. A 68-year-old non-obese African American man with hypertension, smoking and history of hepatitis C presented to the clinic with progressive worsening of lower extremity oedema and declining renal function over few months...
May 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29776430/recurrent-bilateral-mycobacterium-bovis-necrotizing-epididymitis-a-case-report
#12
Simon Grandjean-Lapierre, Simon-Djamel Thiberville, Mustapha Fellag, Christophe Eghazarian, Feriel Bouzid, Christina Gavril, Michel Drancourt
BACKGROUND: Mycobacterium bovis causing tuberculosis in animals is responsible for zoonotic tuberculosis in patients. Veterinary control measures and milk pasteurization has led to a significant decrease in human cases of M. bovis infections in developed countries. CASE PRESENTATION: We diagnosed recurrent M. bovis epididymitis in a 63-year old Caucasian man without any signs of pulmonary or disseminated disease. Relevant epidemiological expositions included camel milk drinking during prolonged travels in Niger, prior to initial clinical manifestations...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29774214/the-expression-of-aqp1-is-modified-in-lung-of-patients-with-idiopathic-pulmonary-fibrosis-addressing-a-possible-new-target
#13
Ana Galán-Cobo, Elena Arellano-Orden, Rocío Sánchez Silva, José Luis López-Campos, César Gutiérrez Rivera, Lourdes Gómez Izquierdo, Nela Suárez-Luna, María Molina-Molina, José A Rodríguez Portal, Miriam Echevarría
Activation of the epithelial-mesenchymal transition process (EMT) by which alveolar cells in human lung tissue undergo differentiation giving rise to a mesenchymal phenotype (fibroblast/miofibroblasts) has been well recognized as a key element in the origin of idiopathic pulmonary fibrosis (IPF). Here we analyzed expression of AQP1 in lung biopsies of patients diagnosed with IPF, and compared it to biopsies derived from patients with diverse lung pneumonies, such as hypersensitivity pneumonitis, sarcoidosis or normal lungs...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29772919/erythema-nodosum-as-the-initial-presentation-of-nivolumab-induced-sarcoidosis-like-reaction
#14
Alexandre Laroche, Evelyn Alarcon Chinchilla, Emilie Bourgeault, Marc-André Doré
BACKGROUND: We report a case of nivolumab-related sarcoidosis-like syndrome that initially presented with erythema nodosum. Sarcoidosis development has been described in single and combination immunotherapy. CASE PRESENTATION: A 68-year-old white woman with metastatic ocular amelanotic choroid melanoma was treated with nivolumab. The patient developed histologically confirmed erythema nodosum lesions and pulmonary granuloma sarcoidosis. Nivolumab was discontinued and the patient started ipilimumab therapy...
May 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29770737/diagnostic-accuracy-and-complications-of-ct-guided-core-needle-lung-biopsy-of-solid-and-part-solid-lesions
#15
Sam Yun, Hee Kang, Young Gyoung Shin, Beom Su Kim, Jun Gu Park, Min Jung Jung
OBJECTIVES: To evaluate whether diagnostic accuracy and complications of computed tomography (CT)-guided core needle biopsy(CNB) differ for solid and part-solid lung lesions. METHODS: This retrospective study included 354 consecutive patients from April 2012 to July 2016 who underwent CT-guided CNB of lung lesions by a radiologist. Patient demographics, lung lesions' characteristics; solid or part-solid, underlying pulmonary disease, distance of path, procedure time, complications (hemorrhage or pneumothorax), histopathological results of biopsy specimens and final diagnosis were reviewed...
May 17, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29769093/granulomatosis-with-polyangiitis-a-17-year-experience-from-a-tertiary-care-hospital-in-pakistan
#16
Omar Irfan, Haris Khan, Zarrar Khan, Alina Ashraf, Rimsha Ahmed, Javaid Ahmad Khan, Ali Bin Sarwar Zubairi
OBJECTIVE: Granulomatosis with Polyangiitis (GPA) is an autoimmune, multi-system, small and medium vessel vasculitis with granulomatous inflammation. Aim of this study was to assess the clinical and radiological presentations of patients with GPA amongst the Pakistani population. It is a single centre retrospective single observation study. RESULTS: Study was conducted at the Aga Khan University Hospital, Karachi with records were reviewed from January 2000 to December 2017...
May 16, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29768566/pulmonary-paracoccidioidomycosis-a-case-report-of-reactivation-in-a-patient-receiving-biological-therapy
#17
Lúcia Carla Polaco Covre, Pâmela Mazzini Hombre, Aloísio Falqueto, Paulo Mendes Peçanha, Valéria Valim
Paracoccidioidomycosis is an endemic disease in Latin America that is rarely associated with immunosuppression and biological therapy. Herein, we report for the first time a case of pulmonary paracoccidioidomycosis reactivation after infliximab treatment. A 47-year-old man from Brazil received infliximab to treat psoriatic spondyloarthropathy and presented with cough, dyspnea, weight loss, and fever. Chest computed tomography revealed a pulmonary nodule and biopsy confirmed paracoccidioidomycosis. Treatment with sulfamethoxazole and trimethoprim was initiated for fungal infection and infliximab was reintroduced two months later...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29768335/igg4-related-disease-of-pulmonary-artery-causing-pulmonary-hypertension
#18
Hui Deng, Sheng Zhao, Yunlong Yue, Yong Liu, Yali Xu, Jin Qian, Xiaorong Ma, Peiliang Gao, Xiaoyan Yao, Xin Jiang, Xiqi Xu, Zhicheng Jing, Yong Wang, Lei Pan, Xinying Xue
IgG4-related disease (IgG4-RD) is recognized as an immune-mediated condition with pathology features of lymphoplasmacytic infiltrate, storiform fibrosis, and obliterative phlebitis, accompanied with or without elevated serum IgG4 concentrations. However, few of pulmonary artery IgG4-RD causing pulmonary hypertension (PH) was reported.The medical records of 3 patients with pulmonary artery IgG4-RD inducing PH were analyzed retrospectively.Imaging findings demonstrated that the lesions of 3 patients located in pulmonary artery, which were initially diagnosed as pulmonary thrombus or malignant tumor...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29765234/perioperative-chemotherapy-with-pemetrexed-and-cisplatin-for-pulmonary-large-cell-neuroendocrine-carcinoma-a-case-report-and-literature-review
#19
Hong Tang, Hongyan Wang, Shaoyan Xi, Chunyu He, Yuxi Chang, Qiming Wang, Yufeng Wu
Background: Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is associated with poor prognosis, and its treatment strategy is still controversial, especially regarding chemotherapy regimens. Case report: We present the case of a 49-year-old Chinese male with primary pulmonary LCNEC treated with neoadjuvant and adjuvant chemotherapy with cisplatin plus pemetrexed. A suspected quasi-circular mass in the left lower pulmonary lobe and an enlarged mediastinal lymph node were found...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29764379/identification-of-usual-interstitial-pneumonia-pattern-using-rna-seq-and-machine-learning-challenges-and-solutions
#20
Yoonha Choi, Tiffany Ting Liu, Daniel G Pankratz, Thomas V Colby, Neil M Barth, David A Lynch, P Sean Walsh, Ganesh Raghu, Giulia C Kennedy, Jing Huang
BACKGROUND: We developed a classifier using RNA sequencing data that identifies the usual interstitial pneumonia (UIP) pattern for the diagnosis of idiopathic pulmonary fibrosis. We addressed significant challenges, including limited sample size, biological and technical sample heterogeneity, and reagent and assay batch effects. RESULTS: We identified inter- and intra-patient heterogeneity, particularly within the non-UIP group. The models classified UIP on transbronchial biopsy samples with a receiver-operating characteristic area under the curve of ~ 0...
May 9, 2018: BMC Genomics
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