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HIV-1 and alcohol

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https://www.readbyqxmd.com/read/28716131/rhabdomyolysis-in-an-hiv-cohort-epidemiology-causes-and-outcomes
#1
Sahar H Koubar, Michelle M Estrella, Rugmini Warrier, Richard D Moore, Gregory M Lucas, Mohamed G Atta, Derek M Fine
BACKGROUND: The Literature on rhabdomyolysis in the HIV-positive population is sparse and limited. We aimed to explore the incidence, patient characteristics, etiologies and outcomes of rhabdomyolysis in a cohort of HIV-positive patients identified through the Johns Hopkins HIV clinical registry between June 1992 and April 2014. METHODS: A retrospective analysis of 362 HIV-positive patients with non-cardiac CK elevation ≥1000 IU/L was performed. Both inpatients and outpatients were included...
July 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28705242/non-communicable-diseases-and-related-risk-behaviors-among-men-and-women-living-with-hiv-in-cambodia-findings-from-a-cross-sectional-study
#2
Pheak Chhoun, Chanrith Ngin, Sovannary Tuot, Khuondyla Pal, Martin Steel, Jennifer Dionisio, Hattie Pearson, Gitau Mburu, Carinne Brody, Siyan Yi
BACKGROUND: There is a growing concern for an increasing burden of non-communicable diseases (NCDs) in people living with HIV. This concern is evident especially in developing countries where dietary and lifestyle risk factors associated with NCDs are becoming more prominent. This study explored the prevalence of diabetes mellitus, hypertension, and hyperlipidemia and related risk factors in men and women living with HIV in Cambodia. METHODS: This cross-sectional study was conducted among 510 adult people living with HIV randomly selected from one city and four provinces in Cambodia...
July 14, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28703726/motherhood-and-risk-for-human-immunodeficiency-virus-sexually-transmitted-infections-among-female-sex-workers-in-the-mexico-us-border-region
#3
Argentina E Servin, Elizabeth Reed, Kimberly C Brouwer, Carlos Magis-Rodriguez, Sabrina Boyce, Steffanie A Strathdee, Jay G Silverman
BACKGROUND: Globally, female sex workers (FSWs) have been identified as a high-risk group for human immunodeficiency virus (HIV) and sexually transmitted infections (STIs). However, as women of reproductive age, FSWs also have children. Few studies have investigated if financial responsibilities associated with motherhood increase women's vulnerability to HIV and STIs among FSWs. METHODS: From March 2013 to March 2014, 603 FSWs aged ≥18 years were recruited from Tijuana and Ciudad Juarez (Mexico) to participate in a study assessing HIV/STI risk environments...
August 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28683982/research-priorities-to-achieve-universal-access-to-hepatitis-c-prevention-management-and-direct-acting-antiviral-treatment-among-people-who-inject-drugs
#4
Jason Grebely, Julie Bruneau, Jeffrey V Lazarus, Olav Dalgard, Philip Bruggmann, Carla Treloar, Matthew Hickman, Margaret Hellard, Teri Roberts, Levinia Crooks, Håvard Midgard, Sarah Larney, Louisa Degenhardt, Hannu Alho, Jude Byrne, John F Dillon, Jordan J Feld, Graham Foster, David Goldberg, Andrew R Lloyd, Jens Reimer, Geert Robaeys, Marta Torrens, Nat Wright, Icro Maremmani, Brianna L Norton, Alain H Litwin, Gregory J Dore
Globally, it is estimated that 71.1 million people have chronic hepatitis C virus (HCV) infection, including an estimated 7.5 million people who have recently injected drugs (PWID). There is an additional large, but unquantified, burden among those PWID who have ceased injecting. The incidence of HCV infection among current PWID also remains high in many settings. Morbidity and mortality due to liver disease among PWID with HCV infection continues to increase, despite the advent of well-tolerated, simple interferon-free direct-acting antiviral (DAA) HCV regimens with cure rates >95%...
July 3, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28679147/at-risk-alcohol-use-is-associated-with-antiretroviral-treatment-nonadherence-among-adults-living-with-hiv-aids
#5
Emily W Paolillo, Assawin Gongvatana, Anya Umlauf, Scott L Letendre, David J Moore
BACKGROUND: Alcohol use is a risk factor for nonadherence to antiretroviral therapy (ART) among people living with HIV/AIDS (PLWHA); however, differences in ART adherence across levels of alcohol use are unclear. This study examined whether "at-risk" alcohol use, defined by National Institute of Alcohol Abuse and Alcoholism guidelines, was associated with ART nonadherence among PLWHA. METHODS: Participants were 535 HIV-infected adults enrolled in studies at the HIV Neurobehavioral Research Program...
July 5, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28678934/-clinical-and-social-vulnerabilities-in-crack-users-according-to-housing-status-a-multicenter-study-in-six-brazilian-state-capitals
#6
Silvia Chwartzmann Halpern, Juliana Nichterwitz Scherer, Vinicius Roglio, Sibele Faller, Anne Sordi, Felipe Ornell, Carla Dalbosco, Flavio Pechansky, Félix Kessler, Lísia von Diemen
The study had the goal to evaluate psychoactive substance use severity, violence, physical and emotional health of crack users who seeks specialized treatment in Psychosocial Care Centers for Alcohol and Drugs (CAPSad) concerning housing status. This is a multicenter cross-sectional study in six Brazilian capitals with 564 crack users categorized into two groups (1) users who have been homeless sometime in life (n = 266) and (2) individuals who have never lived on streets (n = 298). To assess the substance use severity and the characteristics of the individuals, the Addiction Severity Index, 6th version (ASI-6) was used...
July 3, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28665974/hazardous-alcohol-consumption-is-not-associated-with-cd4-t-cell-count-decline-among-plhiv-in-kampala-uganda-a-prospective-cohort-study
#7
Bonnie Wandera, Nazarius M Tumwesigye, Joaniter I Nankabirwa, Andrew D Kambugu, David K Mafigiri, Saidi Kapiga, Ajay K Sethi
INTRODUCTION: There is limited data on the effects of alcohol on immunological response among persons living with HIV (PLHIV) in sub-Saharan Africa. We assessed the relationship between hazardous alcohol use and CD4+ T-cell count, among PLHIV in Uganda. METHODS: PLHIV aged ≥ 18 years were enrolled in a cohort study at the Infectious diseases clinic Kampala, Uganda. Alcohol consumption was assessed at enrolment (baseline) and 6 monthly thereafter using the alcohol use disorders identification test (AUDIT)...
2017: PloS One
https://www.readbyqxmd.com/read/28660356/community-acquired-lower-respiratory-tract-infections-in-hiv-infected-patients-on-antiretroviral-therapy-predictors-in-a-contemporary-cohort-study
#8
Cristiane C Lamas, Lara E Coelho, Beatriz J Grinsztejn, Valdilea G Veloso
Community-acquired pneumonia represents the most frequent bacterial infection in patients with HIV/AIDS. PURPOSE: We aimed to assess variables associated with lower respiratory tract infection (LRTI) among HIV-infected adults using ART. METHODS: A cohort study of HIV-infected patients aged ≥18 years, enrolled from 2000 to 2015, on ART for at least 60 days, with primary outcome as the 1st episode of LRTI during follow-up. The independent variables included were sex at birth, age, race/skin color, educational level, tobacco smoking, alcohol use, cocaine use, diabetes mellitus, CD4 count, HIV viral load, influenza and pneumococcal vaccination...
June 28, 2017: Infection
https://www.readbyqxmd.com/read/28653132/food-insecurity-and-aging-outcomes-in-older-adults-living-with-hiv
#9
Nancy A Hessol, Roland Zepf, Elizabeth Zobell, Sheri D Weiser, Malcolm D John
Little is known about food insecurity and its association with geriatric outcomes in older people living with HIV (PLWH). This was a cross-sectional study of 230 HIV-infected patients aged 50 and older recruited in December 2012 through June 2016. Poisson logistic regression models estimated the prevalence ratio (PR) and 95% confidence intervals (CI) for the association between food insecurity and the following geriatric outcomes: frailty, physical health and function, social support, mental health and cognition, and behavioral health...
June 26, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28621562/association-between-alcohol-consumption-trajectories-and-clinical-profiles-among-women-and-men-living-with-hiv
#10
Natalie E Kelso-Chichetto, Michael Plankey, Alison G Abraham, Nicole Ennis, Xinguang Chen, Robert Bolan, Robert L Cook
BACKGROUND: Alcohol use is common among persons living with HIV (PLWH). It is unclear how alcohol consumption changes over time and if these changes are associated with clinical profiles. OBJECTIVE: We aimed to describe the association between longitudinal patterns of alcohol consumption and the clinical profiles of PLWH. METHODS: Data from the Women's Interagency HIV Study (n = 1123 women) and Multicenter AIDS Cohort Study (n = 597 men) from 2004 to 2013 were utilized...
June 16, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28608973/high-hepatitis-c-cure-rates-among-black-and-non-black-hiv-infected-adults-in-an-urban-center
#11
Oluwaseun Falade-Nwulia, Catherine Sutcliffe, Juhi Moon, Geetanjali Chander, Tanyaporn Wansom, Jeanne Keruly, Jennifer Katzianer, Amy Nathanson, Jillian Marks, Shruti Mehta, David Thomas, Richard Moore, Mark Sulkowski
Background Hepatitis C virus (HCV) cure rates have been similar in patients with and without HIV co-infection; however, in the ION-4 study, black patients treated with ledipasvir/sofosbuvir were significantly less likely to achieve cure (90%) compared to non-black patients (99%). There are limited real world data on the effectiveness of oral direct acting antivirals (DAAs) in predominantly minority HIV/HCV co-infected populations. Methods We analyzed HCV treatment outcomes among 255 HCV co-infected patients initiating DAAs between February 2014 and March 2016 in an urban clinic in Baltimore, Maryland...
June 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28606206/antenatal-depressed-mood-and-child-cognitive-and-physical-growth-at-18-months-in-south-africa-a-cluster-randomised-controlled-trial-of-home-visiting-by-community-health-workers
#12
M Tomlinson, M J Rotheram-Borus, A Scheffler, I le Roux
AIM: To examine the child outcomes at 18-months post-birth of a population cohort of women with antenatal depressed mood, half of whom were randomly chosen to receive perinatal home visits from community health workers during pregnancy. METHOD: Pregnant women in 24 neighbourhoods (98% participation) were randomised by neighbourhood to: (1) standard clinic care (SC; 12 neighbourhoods; n = 594) or (2) the Philani Intervention Program, a home visiting intervention plus standard care (12 neighbourhoods; n = 644)...
June 13, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28600603/hiv-stigma-and-unhealthy-alcohol-use-among-people-living-with-hiv-in-russia
#13
Karsten Lunze, Dmitry Lioznov, Debbie M Cheng, Ruslan V Nikitin, Sharon M Coleman, Carly Bridden, Elena Blokhina, Evgeny Krupitsky, Jeffrey H Samet
Unhealthy alcohol use, highly prevalent in the Russian Federation (Russia), is associated with HIV risk behaviors among people living with HIV (PLWH). HIV stigma contributes to the HIV risk environment in Russia. To examine HIV stigma among Russian PLWH and to explore its association with unhealthy alcohol use, we conducted a longitudinal analysis of 700 PLWH in St. Petersburg, Russia. We assessed the association between alcohol dependence and HIV stigma measured at baseline and 12 months follow-up. Participants with alcohol dependence (n = 446) reported significantly higher HIV stigma scores over time than those without dependence (n = 254) (adjusted mean difference 0...
June 9, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28591256/association-of-outcomes-with-comprehension-adherence-and-behavioral-characteristics-of-tuberculosis-patients-using-fixed-dose-combination-therapy-in-contagem-minas-gerais-brazil
#14
Ana Maria Viegas, Silvana Spíndola de Miranda, João Paulo Haddad, Maria das Graças Ceccato, Wânia da Silva Carvalho
The present study aimed to assess the association of outcomes with comprehension, adherence and behavioral characteristics of tuberculosis (TB) patients using fixed-dose combination (FDC) therapy in the city of Contagem, MG, Brazil. This study used standardized questionnaires to collect data. Outcomes included cure in 77.2% (64/ 83), noncompliance with treatment in 20.4% (17/ 83), and absence of organ failure or death cases. The rate of adherence to treatment was high (71.1% - 59/ 83), while the level of comprehension of the treatment was insufficient for the majority of patients (72...
June 1, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28573088/matrix-metalloproteases-and-their-tissue-inhibitors-in-non-alcoholic-liver-fibrosis-of-human-immunodeficiency-virus-infected-patients
#15
Julio Collazos, Eulalia Valle-Garay, Tomás Suárez-Zarracina, Angel-Hugo Montes, José A Cartón, Víctor Asensi
AIM: To investigate the relationships among diverse metalloproteases (MMPs) and their tissue inhibitors (TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus (HIV)-infected patients. METHODS: Single nucleotide polymorphisms (SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus (HCV) coinfection. A total of 158 patients were included, 57 of whom were HCV-coinfected...
May 12, 2017: World Journal of Virology
https://www.readbyqxmd.com/read/28555316/the-relationship-between-spirituality-religiousness-and-unhealthy-alcohol-use-among-hiv-infected-adults-in-southwestern-uganda
#16
Julian Adong, Christina Lindan, Robin Fatch, Nneka I Emenyonu, Winnie R Muyindike, Christine Ngabirano, Michael R Winter, Christine Lloyd-Travaglini, Jeffrey H Samet, Debbie M Cheng, Judith A Hahn
HIV and alcohol use are two serious and co-existing problems in sub-Saharan Africa. We examined the relationship between spirituality and/or religiousness (SR) and unhealthy alcohol use among treatment-naïve HIV-infected adults attending the HIV clinic in Mbarara, Uganda. Unhealthy alcohol was defined as having either an alcohol use disorders identification test-consumption score of ≥4 for men or ≥3 for women, or having a phosphatidylethanol level of ≥50 ng/ml based on analysis of dried bloodspot specimens...
May 29, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28554608/documented-brief-intervention-not-associated-with-resolution-of-unhealthy-alcohol-use-one-year-later-among-va-patients-living-with-hiv
#17
Emily C Williams, Gwen T Lapham, Jennifer F Bobb, Anna D Rubinsky, Sheryl L Catz, Susan M Shortreed, Kara M Bensley, Katharine A Bradley
OBJECTIVE: Unhealthy alcohol use is particularly risky for patients living with HIV (PLWH). Brief interventions reduce drinking among patients with unhealthy alcohol use, but whether its receipt in routine outpatient settings is associated with reduced drinking among PLWH with unhealthy alcohol use is unknown. We assessed whether PLWH who screened positive for unhealthy alcohol use were more likely to resolve unhealthy drinking one year later if they had brief alcohol intervention (BI) documented in their electronic health record in a national sample of PLWH from the Veterans Health Administration...
July 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28530828/stachybotrysins-a-g-phenylspirodrimane-derivatives-from-the-fungus-stachybotrys-chartarum
#18
Jinlian Zhao, Jiamin Feng, Zhen Tan, Jimei Liu, Jianyuan Zhao, Ridao Chen, Kebo Xie, Dewu Zhang, Yan Li, Liyan Yu, Xiaoguang Chen, Jungui Dai
Seven new phenylspirodrimane derivatives named stachybotrysins A-G (2-8), together with five known compounds (1, 9-12), were isolated from Stachybotrys chartarum CGMCC 3.5365. Stachybotrysin D (5) is the first reported example of a naturally occurring alcoholic O-sulfation of a phenylspirodrimane, and stachybotrysins F and G (7 and 8) are the first examples possessing an isobenzotetrahydrofuran ring with an acetonyl moiety attached. The structures of these compounds were elucidated on the basis of extensive spectroscopic data analysis and by comparison with reported data...
June 23, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28527854/barriers-to-initiation-of-extended-release-naltrexone-among-hiv-infected-adults-with-alcohol-use-disorders
#19
Hélène Chokron Garneau, Alexandra Venegas, Richard Rawson, Lara A Ray, Suzette Glasner
Alcohol consumption is a major risk factor for the acquisition of HIV/AIDS and is associated with greater disease burden and mortality among those who become HIV-infected. Of the extant pharmacological treatments for alcohol use disorders, naltrexone is recognized as one of the most efficacious, producing robust reductions in alcohol craving and use. Given that treatment with oral naltrexone has been limited by problems with adherence, which are particularly prevalent among individuals with multiple chronic, co-occurring conditions, long-acting formulations may be a promising approach for HIV-infected substance users...
May 11, 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28521722/prevalence-and-risk-factors-for-human-immunodeficiency-virus-hiv-and-syphilis-infections-among-military-personnel-in-sierra-leone
#20
Djeneba Audrey Djibo, Foday Sahr, J Allen McCutchan, Sonia Jain, Maria Rosario G Araneta, Stephanie K Brodine, Richard A Shaffer
CONTEXT: HIV and syphilis infections are common in military personnel in sub-Saharan Africa, which impact combat preparedness and increase demands on the military health care system. The prevalence of HIV is estimated at 1.5% among the general population (15-49 years of age) of Sierra Leone, and the estimated syphilis prevalence ranged from 1.5% to 5.2% based on regional studies. We examined the prevalence and risk factors for these two common sexually transmitted infections in the Sierra Leone military personnel...
May 16, 2017: Current HIV Research
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