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https://www.readbyqxmd.com/read/28445303/lifetime-and-recent-alcohol-use-and-bone-mineral-density-in-adults-with-hiv-infection-and-substance-dependence
#1
Alicia S Ventura, Michael R Winter, Timothy C Heeren, Meg M Sullivan, Alexander Y Walley, Michael F Holick, Gregory J Patts, Seville M Meli, Jeffrey H Samet, Richard Saitz
Low bone mineral density (BMD) is common in people living with HIV infection (PLWH), increasing fracture risk. Alcohol use is also common in PLWH and is a modifiable risk factor for both HIV disease progression and low BMD. In PLWH, alcohol's effect on BMD is not well understood.We studied adult PLWH with substance dependence. We measured lifetime alcohol use (kg) and recent (i.e., past 30-day) alcohol use (categorized as: abstinent, low risk, or high risk). In adjusted multivariable regression analyses, we tested associations between lifetime and recent alcohol use and (i) mean BMD (g/cm) at the femoral neck, total hip, and lumbar spine and (ii) low BMD diagnosis (i...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28444057/determinant-factors-of-knowledge-attitudes-and-practices-regarding-std-aids-and-viral-hepatitis-among-youths-aged-18-to-29-years-in-brazil
#2
Miguel Barbosa Fontes, Rodrigo Campos Crivelaro, Alice Margini Scartezini, David Duarte Lima, Alexandre de Araújo Garcia, Rafael Tsuyoshi Fujioka
The scope of this study was to evaluate the vulnerability of Brazilian youths to STDs/HIV&AIDS and Viral Hepatitis. Interviews were conducted with 1,208 youths aged 18 to 29 in 15 states and the Federal District. The regional and national adjusted margin of error of the research was 2.8%. The study was approved by the School of Medicine of Brasilia University with support from PAHO and the Ministry of Health. A scale with 35 questions (knowledge, attitudes and practices) was the main dependent variable. Adjusted linear regression models identified the demographic and social determinant factors that explain scale variations...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28441975/seek-test-treat-substance-using-women-in-the-hiv-treatment-cascade-in-south-africa
#3
Wendee M Wechsberg, Charles van der Horst, Jacqueline Ndirangu, Irene A Doherty, Tracy Kline, Felicia A Browne, Jennifer M Belus, Robin Nance, William A Zule
BACKGROUND: Women in South Africa who use alcohol and other drugs face multiple barriers to HIV care. These barriers make it difficult for women to progress through each step in the HIV treatment cascade from diagnosis to treatment initiation and adherence. This paper examines correlates of HIV status, newly diagnosed HIV status, and use of antiretroviral therapy (ART). METHODS: Outreach workers recruited sexually active Black African women who used substances in Pretoria as part of a U...
April 26, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/28439936/hiv-positive-men-who-have-sex-with-men-are-at-high-risk-of-development-of-significant-liver-fibrosis-after-an-episode-of-acute-hepatitis-c
#4
K Steininger, A Boyd, S Dupke, I Krznaric, A Carganico, M Munteanu, S Neifer, M Schuetze, M Obermeier, K Arasteh, A Baumgarten, P Ingiliz
Acute hepatitis C virus infection remains a major health concern in human immunodeficiency virus(HIV)-infected men who have sex with men (MSM). New direct-acting antiviral agent (DAA) combination therapy has not yet been approved for the treatment for acute hepatitis C virus(HCV), thereby potentially causing deferral of HCV treatment. Therefore, we aimed to study the course of liver disease after an episode of acute HCV. This study is a retrospective single-centre cohort of HIV-positive MSM with acute HCV infection...
April 25, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28439922/illicit-drug-use-among-new-zealand-gay-and-bisexual-men-prevalence-and-association-with-sexual-health-behaviours
#5
Peter Saxton, David Newcombe, Arslan Ahmed, Nigel Dickson, Anthony Hughes
INTRODUCTION AND AIMS: Data are lacking on drug use among gay and bisexual men (GBM) in New Zealand. We establish a baseline estimate of drug use and investigate associations with sexual health and HIV risk. DESIGN AND METHODS: A cross-sectional survey of GBM was conducted in gay community settings and online. Participants were asked their frequency of using nine drugs (poppers, cannabis, ecstasy, methamphetamine, amphetamine, cocaine, LSD, gamma hydroxybutyrate and ketamine) in the previous 6 months...
April 25, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28436758/amphetamine-type-stimulants-ats-use-and-homosexuality-related-enacted-stigma-are-associated-with-depression-among-men-who-have-sex-with-men-msm-in-two-major-cities-in-vietnam-in-2014
#6
Nga Thi Thu Vu, Martin Holt, Huong Thi Thu Phan, Lan Thi La, Gioi Minh Tran, Tung Thanh Doan, Trang Nguyen Nhu Nguyen, John de Wit
BACKGROUND: Men who have sex with men (MSM) are disproportionately affected by mental health concerns, including depression. Amphetamine-type-stimulants (ATS) use and homosexuality-related stigma and discrimination have been found associated with depression among MSM. OBJECTIVES: To assess the prevalence of depression and its associations with ATS use and homosexuality-related stigma and discrimination among MSM in Vietnam. METHODS: 622 MSM were conveniently recruited in Hanoi and Ho Chi Minh city, Vietnam, from September to December 2014...
April 24, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28434056/beyond-the-primary-endpoint-paradigm-a-test-of-intervention-effect-in-hiv-behavioral-intervention-trials-with-numerous-correlated-outcomes
#7
Jessica M Harwood, Robert E Weiss, W Scott Comulada
Behavioral interventions are increasingly based on holistic approaches to health with an understanding that health-related behaviors are linked. A motivating example is provided by the Philani study, an intervention trial conducted to improve the health of South African mothers and their children. Inter-related health problems around maternal alcohol use, malnutrition, and HIV were addressed; multiple endpoints were targeted. The traditional hypothesis testing paradigm that tests significance on one primary outcome did not suffice...
April 22, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28420115/a-cross-sectional-study-on-selected-correlates-of-high-risk-sexual-behavior-in-polish-migrants-resident-in-the-united-kingdom
#8
Maria Ganczak, Grażyna Czubińska, Marcin Korzeń, Zbigniew Szych
Objective: To assess the correlates of the high risk sexual behaviors of Polish migrants in the United Kingdom (UK) after 2004, and to compare such behaviors before/after immigration. Methods: In 2013, a cross-sectional study was conducted through the use of a Computer-assisted web interviewing surveying technique with the use of a self-administered questionnaire. Results: Among 408 respondents (56.9% women), with a median age of 32 years, significantly more admitted to having unprotected sexual contact with a casual partner while in the UK (p < 0...
April 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28414683/recurrent-hypertriglyceridemic-pancreatitis-htgp-and-the-use-of-insulin-drip-as-treatment
#9
T Tran, N Lee
INTRODUCTION: Chronic pancreatitis by definition is a recurrent episode of acute pancreatitis and is commonly associated with alcoholism in the US. Another cause of chronic pancreatitis is hypertriglyceridemia (HTGP);, occurring in 1-5 percent of cases. The incidence of HTGP is higher in patients with diabetes and HIV, usually requiring triglyceride levels > 1000 mg/dL. CASE: A 33 year old man with uncontrolled type 1 diabetes and recurrent pancreatitis, first diagnosed 5 years prior, presented as a transfer from an outside hospital for a recurrent episode of HTGP...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28411067/is-cigarette-and-alcohol-use-associated-with-high-risk-sexual-behaviors-among-youth-in-china
#10
Chao Guo, Xu Wen, Ning Li, Zhenjie Wang, Gong Chen, Xiaoying Zheng
BACKGROUND: Very few studies have explored the association between cigarette or alcohol use and high-risk sexual behaviors (HRSBs) among Chinese youth. AIM: To identify the associations between cigarette and/or alcohol use and HRSBs in unmarried youth 15 to 24 years old in China. METHODS: Data were obtained from a nationally representative survey of youth 15 to 24 years old in China. Population numbers, prevalences, and proportions were calculated where appropriate...
April 11, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28406275/high-self-reported-non-adherence-to-antiretroviral-therapy-amongst-adolescents-living-with-hiv-in-malawi-barriers-and-associated-factors
#11
Maria H Kim, Alick C Mazenga, Xiaoying Yu, Saeed Ahmed, Mary E Paul, Peter N Kazembe, Elaine J Abrams
INTRODUCTION: Globally adolescents and young adults account for more than 40% of new HIV infections, and HIV-related deaths amongst adolescents increased by 50% from 2005 to 2012. Adherence to antiretroviral therapy (ART) is critical to control viral replication and preserve health; however, there is a paucity of research on adherence amongst the growing population of adolescents living with HIV/AIDS (ALHIV) in Southern Africa. We examined levels of self-reported ART adherence, barriers to adherence, and factors associated with non-adherence amongst ALHIV in Malawi...
March 30, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28404135/incidence-risk-factors-and-prevention-of-hepatitis-c-reinfection-a-population-based-cohort-study
#12
Nazrul Islam, Mel Krajden, Jean Shoveller, Paul Gustafson, Mark Gilbert, Jane A Buxton, Jason Wong, Mark W Tyndall, Naveed Zafar Janjua
BACKGROUND: People remain at risk of reinfection with hepatitis C virus (HCV), even after clearance of the primary infection. We identified factors associated with HCV reinfection risk in a large population-based cohort study in British Columbia, Canada, and examined the association of opioid substitution therapy and mental health counselling with reinfection. METHODS: We obtained data from the British Columbia Hepatitis Testers Cohort, which includes all individuals tested for HCV or HIV at the British Columbia Centre for Disease Control Public Health Laboratory during 1990-2013 (when data were available)...
March 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28398960/prevalence-and-risk-factors-of-non-alcoholic-fatty-liver-disease-in-hiv-monoinfection-a-systematic-review-and-meta-analysis
#13
James B Maurice, Amee Patel, Alasdair J Scott, Krish Patel, Mark Thursz, Maud Lemoine
OBJECTIVE: to identify the prevalence and risk factors of NAFLD, NASH and fibrosis in HIV-monoinfected patients. DESIGN: Systematic review and meta-analysis. METHODS: We searched Medline and Embase and included studies that enrolled HIV-monoinfected patients with NAFLD defined by imaging and/or liver histology. Data on prevalence and risk factors for NAFLD, NASH and fibrosis were collected for meta-analysis using random effects models. RESULTS: Ten studies were included from USA (n = 4), Canada (n = 1), France (n = 2), Italy (n = 1), Japan (n = 1) and China (n = 1)...
April 10, 2017: AIDS
https://www.readbyqxmd.com/read/28394804/risk-factors-prevalence-and-site-concordance-of-human-papillomavirus-in-high-risk-greek-men
#14
Savas Tsikis, Lea Hoefer, George Bethimoutis, Electra Nicolaidou, Vassilios Paparizos, Christina Antoniou, Leonidas Chardalias, Georgios-Emmanouil Stavropoulos, Shruti Sharma, Bradley C Long, Ibro Mujacic, Sabah Kadri, Jeremy P Segal, Larissa V Furtado, John Schneider, Angella Charnot-Katsikas
The aim of this study was to determine the risk factors, genotype-specific prevalence, and concordance of human papillomavirus (HPV) infections at three anatomical sites in a cohort of high-risk Greek men. Patients were recruited from sexually transmitted infection and HIV clinics in Athens. Samples were obtained from oral, penile, and anal sites of 294 study participants and HPV testing was performed on 882 samples using next-generation sequencing. Patients also completed a questionnaire assessing risk factors for infection...
April 7, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28393661/persistence-of-macrocytosis-after-discontinuation-of-zidovudine-in-hiv-infected-patients
#15
Inski Yu, Richard N Greenberg, Timothy N Crawford, Alice C Thornton, Thein Myint
The duration of macrocytosis after stopping zidovudine (ZDV) is unknown. Among 104 HIV-infected patients treated with ZDV for more than 1 year, 84 patients had macrocytosis at ZDV discontinuation. The median mean corpuscular volume (MCV) was 114.6 fL (range 100-128 fL). Patients were divided into 2 groups: those who did (resolved macrocytosis, n = 36) and did not (persistent macrocytosis, n = 48) normalize MCV at 3 to 6 months after ZDV discontinuation. Alcohol use ( P = .02), smoking ( P = .03), and lower (but within normal range) folic acid levels ( P = ...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28379111/lifetime-doctor-diagnosed-mental-health-conditions-and-current-substance-use-among-gay-and-bisexual-men-living-in-vancouver-canada
#16
Nathan J Lachowsky, Joshun J S Dulai, Zishan Cui, Paul Sereda, Ashleigh Rich, Thomas L Patterson, Trevor T Corneil, Julio S G Montaner, Eric A Roth, Robert S Hogg, David M Moore
BACKGROUND: Studies have found that gay, bisexual, and other men who have sex with men (GBM) have higher rates of mental health conditions and substance use than heterosexual men, but are limited by issues of representativeness. OBJECTIVES: To determine the prevalence and correlates of mental health disorders among GBM in Metro Vancouver, Canada. METHODS: From 2012 to 2014, the Momentum Health Study recruited GBM (≥16 years) via respondent-driven sampling (RDS) to estimate population parameters...
May 12, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28372551/kidney-disease-in-uganda-a-community-based-study
#17
Robert Kalyesubula, Joaniter I Nankabirwa, Isaac Ssinabulya, Trishul Siddharthan, James Kayima, Jane Nakibuuka, Robert A Salata, Charles Mondo, Moses R Kamya, Donald Hricik
BACKGROUND: Chronic kidney disease (CKD) is a major cause of morbidity and mortality in Sub-Saharan Africa (SSA). The majority of studies on CKD in SSA have been conducted among HIV-infected populations and mainly from large health facilities. We determined the prevalence of CKD and its predictors among populations in communities in central Uganda. METHODS: A cross-sectional study was conducted in Wakiso district using multi-stage sampling. Data was collected on age, sex, socio-economic status, history of alcohol intake, diabetes mellitus, hypertension and smoking...
April 3, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28371092/total-syntheses-of-sesterterpenoid-ansellones%C3%A2-a-and-b-and-phorbadione
#18
Wei Zhang, Hongliang Yao, Jingxun Yu, Zhihong Zhang, Rongbiao Tong
Ansellane-type sesterterpenoids including, ansellones A-G and (+)-phorbadione are structurally novel marine secondary metabolites which exhibit anticancer and anti-HIV activity. The first, asymmetric total syntheses of three structurally representative members, (-)-ansellones A and B and (+)-phorbadione, were accomplished in 16-23 steps from (+)-sclareolide. The route features the first regioselective cyclization of vinyl epoxides with internal alcohol nucleophiles in a 1,4-addition manner (SN 2'). Additionally, the allylic C-H oxidation was exploited at a late stage of the synthesis of (-)-ansellone A and (+)-phorbadione...
March 28, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28370504/cyp1a1m1-and-cyp2c9-2-and-3-polymorphism-and-risk-to-develop-arv-associated-hepatotoxicity-and-its-severity
#19
HariOm Singh, Sonam Lata, Vijay Nema, Dharmesh Samani, Manisha Ghate, Raman R Gangakhedkar
Non-nucleoside reverse transcriptase inhibitors are metabolized in the liver by cytochrome P450 (CYP) isoenzymes. Variations in the genes encoding these enzymes may influence the activity of corresponding metabolizing enzymes. This study aimed at assessing association of CYP2C9*2 430C/T, CYP2C9*31075A/C, and CYP1A1m1 3801T/C polymorphism with risk to develop ARV Antiretroviral-associated hepatotoxicity and its severity. In this case-control study, genotyping of CYP2C9*2, CYP2C9*3, and CYP1A1m1 genes was done in 34 HIV-infected individuals with hepatotoxicity and 131 without hepatotoxicity, and 153 unrelated healthy individuals using PCR-RFLP...
April 3, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28363929/tobacco-and-alcohol-use-among-drug-users-receiving-methadone-maintenance-treatment-a-cross-sectional-study-in-a-rural-prefecture-of-yunnan-province-southwest-china
#20
Song Duan, Ziyi Jin, Xing Liu, Yuecheng Yang, Runhua Ye, Renhai Tang, Meiyang Gao, Yingying Ding, Na He
OBJECTIVE: To estimate the prevalence of ever, current and heavy tobacco and alcohol use and their correlates among patients undergoing methadone maintenance treatment (MMT). DESIGN: Cross-sectional study. SETTING: The study was conducted in all of the 5 MMT clinics in Dehong Prefecture, China. PARTICIPANTS: 2121 (81.6%) eligible MMT participants were included in the study population. ANALYSIS: Ordinal logistic regression was used to estimate the ORs and their 95% CIs...
March 30, 2017: BMJ Open
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