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https://www.readbyqxmd.com/read/29148637/psychoactive-substance-use-among-nigerian-cohort-with-hiv-aids-frequency-types-and-demographic-correlates
#1
Andrew Toyin Olagunju, Olasimbo Adenike Ogundipe, Tinuke Oluwasefunmi Olagunju, Oluseyi Ayodeji Campbell, Olatunji Francis Aina, Alani Sulaimon Akanmu
Introduction: There are good pointers from literature to the detrimental impacts of psychoactive substance use in HIV/AIDS patients. This study aimed at investigating the prevalence, types and demographic correlates of psychoactive substance use among people living with HIV/AIDS. Methods: The study participants consisted of 295 adults with HIV/AIDS and were interviewed with a designed questionnaire that consisted of two parts. The first part contained questions to elicit socio-demographic and treatment related information of the participants, while the second part focused on psychoactive substance use...
January 2017: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/29145741/a-cohort-approach-to-real-time-detection-of-acute-hiv-infections-among-people-who-inject-drugs-in-st-petersburg-russia
#2
Olga Toussova, Andrei Kozlov, Sergei Verevochkin, Kathryn Lancaster, Alla Shaboltas, Alexey Masharsky, Elena Dukhovlinova, William C Miller, Irving Hoffman
OBJECTIVES: To detect acute HIV infections (AHI) in real time among people who inject drugs (PWID) in St. Petersburg, Russia and to test the feasibility of this approach. DESIGN: Prospective cohort study. METHODS: 100 seronegative or acutely HIV-infected at screening PWID were enrolled and followed until the end of the 12 month pilot period. Each participant was evaluated, tested and counseled for HIV monthly. Two HIV tests were used: HIV antibody and HIV RNA PCR...
November 16, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29136655/socio-behavioral-risk-factors-among-older-adults-living-with-hiv-in-thailand
#3
Patou Masika Musumari, Arunrat Tangmunkongvorakul, Kriengkrai Srithanavibooncha, Mitchell D Feldman, Wathee Sitthi, Kittipan Rerkasem, Teeranee Techasrivichien, S Pilar Suguimoto, Masako Ono-Kihara, Masahiro Kihara
BACKGROUND: There has been a global increase in HIV infection in persons 50 years of age and older. This group is at risk for development of chronic illness that may be exacerbated by socio-behavioral risk factors such as smoking, unhealthy alcohol use, and sedentary lifestyle. However, socio-behavioral risk factors in this older HIV infected population are not well described. The current study aims to describe and document factors related to alcohol use, tobacco smoking, and physical exercise in older adults living with HIV (OALHIV)...
2017: PloS One
https://www.readbyqxmd.com/read/29132227/oxidative-stress-in-hiv-infection-and-alcohol-use-role-of-redox-signals-in-modulation-of-lipid-rafts-and-abc-transporters
#4
Samikkannu Thangavel, Carmen T Mulet, Venkata S R Atluri, Marisela Agudelo, Rhonda Rosenberg, Jessy G Devieux, Madhavan P N Nair
AIMS: HIV infection induces oxidative stress and alcohol use accelerates disease progression subsequently causing immune dysfunction. However, HIV and alcohol impact on lipid rafts-mediated immune dysfunction remains unknown. In this study, we investigate the modulation by which oxidative stress induces reactive oxygen species (ROS) affecting redox expression, lipid rafts caveiloin-1, ATP-binding cassette (ABC)-transporters, and transcriptional SREBP gene and protein modification and how these mechanisms are associated with arachidonic acid (AA) metabolites in HIV positive alcohol users, and how they escalate immune dysfunction...
November 13, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29129192/healthcall-delivered-via-smartphone-to-reduce-co-occurring-drug-and-alcohol-use-in-hiv-infected-adults-a-randomized-pilot-trial
#5
Efrat Aharonovich, Malka Stohl, Daniela Cannizzaro, Deborah Hasin
AIMS: Co-occurrence of drug and alcohol use among people living with HIV is linked to poor medication adherence and lack of viral suppression. HealthCall, a technological enhancement of brief Motivational Interviewing (MI), involves brief daily self-monitoring, positive reinforcement, and personalized feedback. This randomized pilot study among people living with HIV investigated the feasibility and efficacy of reducing non-injection drug and alcohol use with MI+HealthCall as adapted for smartphone technology...
December 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29126667/smartphone-based-ecological-momentary-assessment-ema-of-alcohol-and-cannabis-use-in-older-adults-with-and-without-hiv-infection
#6
Emily W Paolillo, Lisa C Obermeit, Bin Tang, Colin A Depp, Florin Vaida, David J Moore, Raeanne C Moore
INTRODUCTION: Ecological momentary assessment (EMA) has been used to characterize substance use among adult populations; however, little is known about the validity of EMA and the patterns and predictors of substance use among older adults with and without HIV infection. METHODS: Thirty-five (22 HIV-positive, 13 HIV-negative) older adults aged 50-74 were assessed for 14days and completed up to four smartphone-based surveys per day. RESULTS: Participants completed an average of 89...
October 26, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29121596/the-impact-of-long-term-moderate-and-heavy-alcohol-consumption-on-incident-atherosclerosis-among-persons-living-with-hiv
#7
N E Kelso-Chichetto, M Plankey, D S Sheps, A G Abraham, X Chen, S Shoptaw, R C Kaplan, W S Post, R L Cook
BACKGROUND: Level of alcohol consumption is associated with differential risk of atherosclerosis, but little research has investigated this association among HIV+ persons. We evaluated the association between long-term alcohol use and incident atherosclerosis among HIV+ persons. METHODS: We utilized data from HIV+ participants of the Women's Interagency HIV Study (n=483) and the Multicenter AIDS Cohort Study (n=305) without history of cardiovascular disease. Atherosclerosis was assessed two times by B-mode carotid artery ultrasound imaging from 2004 to 2013...
October 28, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29113506/latent-classes-and-cumulative-impacts-of-adverse-childhood-experiences
#8
Gia Elise Barboza
Studies of adverse childhood experiences (ACEs) have gauged severity using a cumulative risk (CR) index. Few studies have focused on the nature of the context of adversity and their association with psychosocial outcomes. The objective of this study was to examine the patterning of ACEs and to explore the resultant patterns' association with HIV risk-taking, problem drinking, and depressive symptoms in adulthood. Latent class analysis (LCA) was used to identify homogeneous, mutually exclusive "classes" of 11 of the most commonly used ACEs...
January 1, 2017: Child Maltreatment
https://www.readbyqxmd.com/read/29112041/alcohol-and-mortality-combining-self-reported-audit-c-and-biomarker-detected-peth-alcohol-measures-among-hiv-infected-and-uninfected
#9
Oghenowede Eyawo, Kathleen A McGinnis, Amy C Justice, David A Fiellin, Judith A Hahn, Emily C Williams, Adam J Gordon, Brandon D L Marshall, Kevin L Kraemer, Stephen Crystal, Julie R Gaither, E Jennifer Edelman, Kendall J Bryant, Janet P Tate
BACKGROUND: Unhealthy alcohol use may be particularly detrimental among individuals living with HIV and/or HCV, and is often under-reported. Direct biomarkers of alcohol exposure may facilitate improved detection of alcohol use. METHODS: We evaluated the association of alcohol exposure determined by both self-report (Alcohol Use Disorders Identification Test-Consumption [AUDIT-C]) and a direct biomarker (phosphatidylethanol [PEth]), with mortality among HIV-infected and uninfected in the VACS-Biomarker Cohort...
November 2, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29110408/design-synthesis-biological-evaluation-and-x-ray-studies-of-hiv-1-protease-inhibitors-with-modified-p2-ligands-of-darunavir
#10
Arun K Ghosh, W Sean Fyvie, Margherita Brindisi, Melinda Steffey, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Masayuki Amano, Irene T Weber, Hiroaki Mitsuya
The structure-based design, synthesis, and biological evaluation of a series of nonpeptidic HIV-1 protease inhibitors with rationally designed P2' ligands are described. The inhibitors are designed to enhance backbone binding interactions, particularly at the S2'-subsite. Synthesis of inhibitors was carried out efficiently. The stereochemistry of alcohol functionalities of the P2'-ligands was set by asymmetric reduction of the corresponding ketone using (R,R)- or (S,S)-Noyori's catalysts. A number of inhibitors displayed very potent enzyme inhibitory and antiviral activity...
November 6, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29108022/risk-factors-for-hiv-infection-among-female-sex-workers-in-bangui-central-african-republic
#11
Jean De Dieu Longo, Marcel Mbeko Simaleko, Henri Saint-Calvaire Diemer, Gérard Grésenguet, Gilles Brücker, Laurent Belec
OBJECTIVE: The aims of the study were i) to categorize female sex workers (FSW) according to socio-anthropologic criteria in Bangui; ii) to examine the association between a selection of demographic and risk variables with the different categories of female sex work as outcome, and iii) to investigate factors associated with HIV status. METHODS: A cross-sectional questionnaire survey was conducted to describe the spectrum of commercial sex work in Bangui among 345 sexually active women...
2017: PloS One
https://www.readbyqxmd.com/read/29075137/high-prevalence-of-pain-among-adult-hiv-infected-patients-at-university-of-gondar-hospital-northwest-ethiopia
#12
Abere Woretaw Azagew, Hiwot Kassa Woreta, Ambaye Dejen Tilahun, Degefaye Zelalem Anlay
BACKGROUND: HIV/AIDS are pressing global health problems. Pain is a common symptom reported by patients living with HIV/AIDS. The exact cause of pain in HIV patients has not been thoroughly described, but it may, due to a symptom of HIV itself, result from opportunistic infections, as a side effect of antiretroviral drugs, concurrent neoplasia or other causes. In addition, pain perception of HIV-infected patients is highly variable and may vary based on cultural context and patient demographics...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29074409/global-prevalence-of-injecting-drug-use-and-sociodemographic-characteristics-and-prevalence-of-hiv-hbv-and-hcv-in-people-who-inject-drugs-a-multistage-systematic-review
#13
Louisa Degenhardt, Amy Peacock, Samantha Colledge, Janni Leung, Jason Grebely, Peter Vickerman, Jack Stone, Evan B Cunningham, Adam Trickey, Kostyantyn Dumchev, Michael Lynskey, Paul Griffiths, Richard P Mattick, Matthew Hickman, Sarah Larney
BACKGROUND: Sharing of equipment used for injecting drug use (IDU) is a substantial cause of disease burden and a contributor to blood-borne virus transmission. We did a global multistage systematic review to identify the prevalence of IDU among people aged 15-64 years; sociodemographic characteristics of and risk factors for people who inject drugs (PWID); and the prevalence of HIV, hepatitis C virus (HCV), and hepatitis B virus (HBV) among PWID. METHODS: Consistent with the GATHER and PRISMA guidelines and without language restrictions, we systematically searched peer-reviewed databases (MEDLINE, Embase, and PsycINFO; articles published since 2008, latest searches in June, 2017), searched the grey literature (websites and databases, searches between April and August, 2016), and disseminated data requests to international experts and agencies (requests sent in October, 2016)...
December 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29067831/social-and-structural-factors-increase-inconsistent-condom-use-by-sex-workers-one-time-and-regular-clients-in-northern-uganda
#14
Putu Duff, Josephine Birungi, Sabina Dobrer, Monika Akello, Godfrey Muzaaya, Kate Shannon
While sex workers (SWs) bear the brunt of the epidemic in Uganda, there remains a dearth of empirical research on the structural drivers of HIV prevention among SWs. This study examined the drivers of inconsistent condom use by one-time and regular clients of young women SWs in Gulu, Northern Uganda. Data were drawn from the Gulu Sexual Health Study, a cross-sectional study of young SWs, aged 14 years and older (2011-2012). SWs were recruited using peer/SW-led outreach, in partnership with The AIDS Support Organization and other CBOs...
October 25, 2017: AIDS Care
https://www.readbyqxmd.com/read/29065199/prevalence-and-correlates-of-smoking-among-people-living-with-hiv-in-south-africa
#15
Jessica L Elf, Ebrahim Variava, Sandy Chon, Limakatso Lebina, Katlego Motlhaoleng, Nikhil Gupte, Raymond Niaura, David Abrams, Jonathan E Golub, Neil Martinson
Introduction: Smoking likely exacerbates comorbidities which people living with HIV (PLWH) are predisposed. We assessed prevalence and correlates of smoking among PLWH in South Africa, which has 7 million PLWH but inadequate reporting of smoking. Methods: A cross-sectional survey was conducted among randomly selected adults with HIV infection in Klerksdorp, South Africa. Current smoking was assessed by questionnaire, exhaled carbon monoxide (eCO), and urine cotinine...
June 21, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29063817/the-intersection-of-intimate-partner-violence-and-hiv-risk-among-women-engaging-in-transactional-sex-in-ugandan-fishing-villages
#16
Katelyn M Sileo, Michael Kintu, Susan M Kiene
Intimate partner violence (IPV) may increase risk for HIV/AIDS among women engaging in transactional sex in Ugandan fishing communities. In this cross-sectional study, 115 women reporting engaging in transactional sex in Lake Victoria fishing communities completed a computerized interview. We tested associations between IPV and other HIV risk factors, with unprotected sex and HIV status, and tested moderators of the IPV-HIV risk relationship. Women reporting recent sexual IPV reported 3.36 times more unprotected sex acts (AdjExp[B] = 3...
October 24, 2017: AIDS Care
https://www.readbyqxmd.com/read/29057006/risk-factors-for-self-report-of-not-receiving-an-hiv-test-among-adolescents-in-nyc-with-a-history-of-sexual-intercourse-2013-yrbs
#17
Tina Y Gao, Chanelle J Howe, Andrew R Zullo, Brandon D L Marshall
The Centers for Disease Control and Prevention (CDC) has previously recommended that all adolescents undergo HIV testing in the United States (US). Despite these recommendations, national HIV testing among US adolescents has remained low. This study estimated the prevalence of and identified risk factors for not receiving an HIV test among adolescents with a history of sexual intercourse in New York City (NYC), an urban area that has been greatly impacted by the HIV epidemic. Cross-sectional data on 1,199 NYC high school students who completed the 2013 NYC Youth Risk Behavior Survey were used...
2017: Vulnerable Children and Youth Studies
https://www.readbyqxmd.com/read/29047000/latent-class-analysis-of-hiv-risk-behaviors-among-russian-women-at-risk-for-alcohol-exposed-pregnancies
#18
Som Bohora, Mark Chaffin, Alla Shaboltas, Barbara Bonner, Galina Isurina, Julia Batluk, David Bard, Larissa Tsvetkova, Larissa Skitnevskaya, Elena Volkova, Tatiana Balachova
The number of HIV cases attributed to heterosexual contact and the proportion of women among HIV positive individuals has increased worldwide. Russia is a country with the highest rates of newly diagnosed HIV infections in the region, and the infection spreads beyond traditional risk groups. While young women are affected disproportionately, knowledge of HIV risk behaviors in women in the general population remains limited. The objectives of this study were to identify patterns of behaviors that place women of childbearing age at high risk for HIV transmission and determine whether socio-demographic characteristics and alcohol use are predictive of the risk pattern...
November 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29030717/baseline-cigarette-smoking-status-as-a-predictor-of-virologic-suppression-and-cd4-cell-count-during-one-year-follow-up-in-substance-users-with-uncontrolled-hiv-infection
#19
Theresa Winhusen, Daniel J Feaster, Rui Duan, Jennifer L Brown, Eric S Daar, Raul Mandler, Lisa R Metsch
Cigarette smoking is prevalent in people living with HIV/AIDS (PLHIV) who abuse alcohol and/or illicit substances. This study evaluated whether smoking is predictive of virologic non-suppression (> 200 copies/mL) and low CD4 count (< 200 cells/mm(3)) during 1-year follow-up in medically hospitalized, substance-using PLHIV recruited for a multi-site trial. Smoking status was assessed with the Heaviness of Smoking Index (HSI). Analyses revealed that, controlling for baseline differences and adherence to antiretroviral therapy, non-smokers (n = 237), compared to smokers scoring in the medium-to-high range on the HSI (n = 386), were significantly more likely to achieve viral suppression (OR 1...
October 13, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29026869/associations-between-antiretroviral-treatment-and-avascular-bone-necrosis-the-swiss-hiv-cohort-study
#20
Cornelia Bayard, Bruno Ledergerber, Markus Flepp, Thanh Lecompte, Estelle Moulin, Matthias Hoffmann, Rainer Weber, Cornelia Staehelin, Caroline Di Benedetto, Christoph A Fux, Philip E Tarr, Barbara Hasse
BACKGROUND: HIV-infected individuals have an increased risk of avascular bone necrosis (AVN). Antiretroviral therapy (ART) and particularly protease inhibitors (PI) have been implicated as a risk factor. We aimed to study the associations of ART with the occurrence of AVN among Swiss HIV Cohort Study participants (SHCS). METHODS: We used incidence density sampling to perform a case control study within the Swiss HIV Cohort Study (SHCS) comparing prospectively collected AVN cases and controls by conditional logistic regression analysis...
2017: Open Forum Infectious Diseases
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