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Laser evoked potentials

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https://www.readbyqxmd.com/read/29913679/assessment-of-small-fibers-using-evoked-potentials
#1
Caspar Skau Madsen, Nanna Brix Finnerup, Ulf Baumgärtner
Background and purpose Conventional neurophysiological techniques do not assess the function of nociceptive pathways and are inadequate to detect abnormalities in patients with small-fiber damage. This overview aims to give an update on the methods and techniques used to assess small fiber (Aδ- and C-fibers) function using evoked potentials in research and clinical settings. Methods Noxious radiant or contact heat allows the recording of heat-evoked brain potentials commonly referred to as laser evoked potentials (LEPs) and contact heat-evoked potentials (CHEPs)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29905040/-promotion-of-transplanted-collagen-scaffolds-combined-with-brain-derived-neurotrophic-factor-for-axonal-regeneration-and-motor-function-recovery-in-rats-after-transected-spinal-cord-injury
#2
Xi Chen, Yongheng Fan, Zhifeng Xiao, Xing Li, Bin Yang, Yannan Zhao, Xianglin Hou, Sufang Han, Jianwu Dai
Objective: To evaluate the effect of the combination of collagen scaffold and brain-derived neurotrophic factor (BDNF) on the repair of transected spinal cord injury in rats. Methods: Thirty-two Sprague-Dawley rats were randomly divided into 4 groups: group A (sham operation group), T 9 , T 10 segments of the spinal cord was only exposed; group B, 4-mm T 9 , T 10 segments of the spinal cord were resected; group C, 4-mm T 9 , T 10 segments of the spinal cord were resected and linear ordered collagen scaffolds (LOCS) with corresponding length was transplanted into lesion site; group D, 4-mm T 9 , T 10 segments of the spinal cord were resected and LOCS with collagen binding domain (CBD)-BDNF was transplanted into lesion site...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29904336/magnitude-and-temporal-variability-of-inter-stimulus-eeg-modulate-the-linear-relationship-between-laser-evoked-potentials-and-fast-pain-perception
#3
Linling Li, Gan Huang, Qianqian Lin, Jia Liu, Shengli Zhang, Zhiguo Zhang
The level of pain perception is correlated with the magnitude of pain-evoked brain responses, such as laser-evoked potentials (LEP), across trials. The positive LEP-pain relationship lays the foundation for pain prediction based on single-trial LEP, but cross-individual pain prediction does not have a good performance because the LEP-pain relationship exhibits substantial cross-individual difference. In this study, we aim to explain the cross-individual difference in the LEP-pain relationship using inter-stimulus EEG (isEEG) features...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29890373/small-fibre-neuropathy-in-mitochondrial-diseases-explored-with-sudoscan
#4
Marco Luigetti, Guido Primiano, Cristina Cuccagna, Daniela Bernardo, Donato Sauchelli, Catello Vollono, Serenella Servidei
OBJECTIVE: Polyneuropathy in mitochondrial diseases (MDs) is relatively common and widely investigated, but few data are instead reported about small fibres involvement. METHODS: In order to investigate the involvement of small fibres in MDs we performed extensive neurophysiological test (nerve conduction studies; sympathetic skin response; sudoscan) in 27 patients with genetic diagnosis of MD (7 m.3243A > G; 4 m.8344A > G; 9 single mtDNA deletion; 7 multiple mtDNA deletions)...
June 1, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29864967/topical-allyl-isothiocyanate-mustard-oil-as-a-trpa1-dependent-human-surrogate-model-of-pain-hyperalgesia-and-neurogenic-inflammation-a-dose-response-study
#5
H H Andersen, S Lo Vecchio, P Gazerani, L Arendt-Nielsen
Aims Transient receptor potential ion channel A1 (TRPA1) has been shown to play a pathoetiological role in several painful and inflammatory conditions and therefore several new drug candidates, targeting TRPA1 are currently being developed [1]. While the natural TRPA1-agonist allyl-isothiocyanate (AITC, known as "mustard oil") is an exceedingly common animal pain model, it has only been sparsely investigated as a potential human surrogate model of pain and neurogenic inflammation. This study aimed to evaluate dose-response features of AITC as a sensitizing, algogenic irritant in human skin...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29659054/tuning-in-c-nociceptors-to-reveal-mechanisms-in-chronic-neuropathic-pain
#6
Robin Jonas, Barbara Namer, Lenka Stockinger, Kim Chisholm, Mark Schnakenberg, Gunther Landmann, Mateusz Kucharczyk, Christoph Konrad, Roland Schmidt, Richard Carr, Stephen McMahon, Martin Schmelz, Roman Rukwied
OBJECTIVE: Develop and validate a low-intensity sinusoidal electrical stimulation paradigm to preferentially activate C-fibers in human skin. METHODS: Sinusoidal transcutaneous stimulation (4Hz) was assessed psychophysically in healthy volunteers (n = 14) and neuropathic pain patients (n = 9). Pursuing laser Doppler imaging and single nociceptor recordings in vivo in humans (microneurography) and pigs confirmed the activation of "silent" C-nociceptors...
April 16, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29644578/functional-mri-and-laser-evoked-potentials-evaluation-in-charcot-marie-tooth-syndrome
#7
Simona De Salvo, Lilla Bonanno, Roberto Giorgianni, Nunzio Muscarà, Francesco Freni, Fabrizia Caminiti, Demetrio Milardi, Placido Bramanti, Silvia Marino
Charcot-Marie-Tooth (CMT) disease is a genetically heterogeneous group of disorders. Pain is a less common symptom complained by CMT patients. We described a case of a 39-year-old male patient affect by Charcot-Marie-Tooth (CMT) disease compared to five healthy controls (HC), to assess the sensory and the nociceptive pathways by using LEPs recording associated to fMRI examination, to find an "objective" marker which could be used in the management of CMT patient. The nociceptive system was evaluated by laser-evoked potentials (LEPs)...
April 11, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29567583/event-related-brain-potentials-elicited-by-high-speed-cooling-of-the-skin-a-robust-and-non-painful-method-to-assess-the-spinothalamic-system-in-humans
#8
Roxane De Keyser, Emanuel N van den Broeke, Arthur Courtin, André Dufour, André Mouraux
OBJECTIVE: To investigate whether cool-evoked potentials (CEP) elicited by brisk innocuous cooling of the skin could serve as an alternative to laser-evoked potentials (LEP), currently considered as the best available neurophysiological tool to assess the spinothalamic tract and diagnose neuropathic pain. METHODS: A novel device made of micro-Peltier elements and able to cool the skin at -300 °C/s was used to record CEPs elicited by stimulation of the hand dorsum in 40 healthy individuals, characterize the elicited responses, and assess their signal-to-noise ratio...
May 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29550652/laser-evoked-potential-amplitude-and-laser-pain-rating-reduction-during-high-frequency-non-noxious-somatosensory-stimulation
#9
Massimiliano Valeriani, Costanza Pazzaglia, Vincenzo Rizzo, Angelo Quartarone, Catello Vollono
OBJECTIVE: To investigate the mechanism subtending the analgesic effect of high frequency non-painful somatosensory stimulation. METHODS: Laser evoked potentials (LEPs) and laser-pain rating were obtained from healthy subjects to stimulation of different parts of the body. LEPs were recorded at baseline and during non-painful electrical stimulation of the superficial branch of the right radial nerve (RRES). RESULTS: RRES reduced N2/P2 LEP amplitude to right radial (F(8,10)  = 82...
May 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29491443/long-term-optical-brain-imaging-in-live-adult-fruit-flies
#10
Cheng Huang, Jessica R Maxey, Supriyo Sinha, Joan Savall, Yiyang Gong, Mark J Schnitzer
Time-lapse in vivo microscopy studies of cellular morphology and physiology are crucial toward understanding brain function but have been infeasible in the fruit fly, a key model species. Here we use laser microsurgery to create a chronic fly preparation for repeated imaging of neural architecture and dynamics for up to 50 days. In fly mushroom body neurons, we track axonal boutons for 10 days and record odor-evoked calcium transients over 7 weeks. Further, by using voltage imaging to resolve individual action potentials, we monitor spiking plasticity in dopamine neurons of flies undergoing mechanical stress...
February 28, 2018: Nature Communications
https://www.readbyqxmd.com/read/29458751/somatosensory-function-is-impaired-in-patients-with-idiopathic-rem-sleep-behaviour-disorder
#11
A V Strobel, H Tankisi, N B Finnerup, A Fuglsang-Frederiksen, P Jennum, K B Svendsen, F I Kirov, M Otto
BACKGROUND: Idiopathic REM sleep behaviour disorder (iRBD) has been recognised as a significant biomarker for developing a neurodegenerative alpha-synucleinopathy, which is why iRBD is considered to be a prodromal state for alpha-synucleinopathies including Parkinson's disease (PD). Many patients with PD suffer from complaints of pain and present impaired somatosensory function. We hypothesized that pain perception and somatosensory function could be altered already in a preclinical stage of PD including iRBD...
February 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29378016/a-phase-i-randomized-double-blind-laser-evoked-potential-study-to-evaluate-the-analgesic-antihyperalgesic-effect-of-asp9226-a-state-dependent-n-type-voltage-gated-calcium-channel-inhibitor-in-healthy-male-subjects
#12
Klaus Schaffler, Weizhong He, Paul Passier, Katherine Tracy, Allam Fakhoury, Jeffrey Paul
Objective: Evaluate the analgesic/antihyperalgesic effects of ASP9226, a state-dependent N-type voltage-gated calcium channel inhibitor, in healthy male subjects. Design: Randomized, double-blind, double-dummy, placebo- and active comparator-controlled crossover study. Setting: HPR Dr. Schaffler GmbH, Munich, Germany. Subject: Healthy male subjects aged 18-55 years. Methods: Twenty-four eligible subjects were randomly assigned to one of four treatment sequences and received single doses of ASP9226 (30 mg or 50 mg), pregabalin (150 mg), or placebo during four treatment periods...
January 25, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29367165/evaluation-of-afferent-pain-pathways-in-adrenomyeloneuropathic-patients
#13
Sara Yagüe, Misericordia Veciana, Carlos Casasnovas, Montserrat Ruiz, Jordi Pedro, Josep Valls-Solé, Aurora Pujol
OBJECTIVE: Patients with adrenomyeloneuropathy may have dysfunctions of visual, auditory, motor and somatosensory pathways. We thought on examining the nociceptive pathways by means of laser evoked potentials (LEPs), to obtain additional information on the pathophysiology of this condition. METHODS: In 13 adrenomyeloneuropathic patients we examined LEPs to leg, arm and face stimulation. Normative data were obtained from 10 healthy subjects examined in the same experimental conditions...
March 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29314454/neurophysiological-comparison-among-tonic-high-frequency-and-burst-spinal-cord-stimulation-novel-insights-into-spinal-and-brain-mechanisms-of-action
#14
Tommaso Bocci, Giuliano De Carolis, Mery Paroli, Davide Barloscio, Laura Parenti, Lara Tollapi, Massimiliano Valeriani, Ferdinando Sartucci
RATIONALE: Spinal cord stimulation (SCS) is an effective option for neuropathic pain treatment. New technological developments, as high-frequency (HF) and theta burst stimulation (TBS), have shown promising results, although putative mechanisms of action still remain debated. METHODS: thirty patients with lower back pain were enrolled and underwent LF, HF, and TBS. Laser evoked potentials (LEPs) were recorded by using a Nd:YAG laser. Amplitudes and latencies of the main two components (N1, N2/P2) were compared among different experimental sessions...
January 4, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29311491/visual-evoked-potential-in-rabbits-eyes-with-subretinal-implantation-by-vitrectomy-of-okayama-university-type-retinal-prosthesis-ourep-tm
#15
Toshihiko Matsuo, Tetsuya Uchida, Koichiro Yamashita, Shigiko Takei, Daisuke Ido, Mamoru Tanaka, Masao Oguchi, Toshinori Furukawa
Okayama University-type retinal prosthesis (OURePTM ) is a photoelectric dye-coupled polyethylene film which generates electric potential in response to light and stimulates nearby neurons. This study aims to test surgical feasibility for subretinal film implantation and to examine functional durability of films in subretinal space. Dye-coupled films were implanted subretinally by vitrectomy in the right eye of normal white rabbits: 8 rabbits for 1 month and 8 rabbits for 6 months. The implanted films were removed by vitrectomy in 4 of these 8 rabbits in 1-month or 6-month implantation group...
February 9, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29260349/neural-mechanisms-of-attentional-switching-between-pain-and-a-visual-illusion-task-a-laser-evoked-potential-study
#16
Andrej Stancak, Nicholas Fallon, Alessandra Fenu, Katerina Kokmotou, Vicente Soto, Stephanie Cook
Previous studies demonstrated that pain induced by a noxious stimulus during a distraction task is affected by both stimulus-driven and goal-directed processes which interact and change over time. The purpose of this exploratory study was to analyse associations of aspects of subjective pain experience and engagement with the distracting task with attention-sensitive components of noxious laser-evoked potentials (LEPs) on a single-trial basis. A laser heat stimulus was applied to the dorsum of the left hand while subjects either viewed the Rubin vase-face illusion (RVI), or focused on their pain and associated somatosensory sensations occurring on their stimulated hand...
May 2018: Brain Topography
https://www.readbyqxmd.com/read/29228247/a-randomized-double-blind-placebo-and-active-comparator-controlled-phase-i-study-of-analgesic-antihyperalgesic-properties-of-asp8477-a-fatty-acid-amide-hydrolase-inhibitor-in-healthy-female-subjects
#17
Klaus Schaffler, Ashraf Yassen, Peter Reeh, Paul Passier
Objectives: To evaluate the analgesic/antihyperalgesic effect of ASP8477. Design: Randomized, double-blind, double-dummy, cross-over, placebo- and active comparator-controlled study. Setting: HPR Dr. Schaffler GmbH, Munich, Germany. Subjects: Healthy female subjects aged 18-65 years. Methods: Eligible subjects were randomly assigned to one of six treatment sequences and received multiple ascending doses of ASP8477, duloxetine, and placebo over three treatment periods (each consisting of 21-day dosing separated by 14-day washout periods)...
December 8, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29201002/a-comparison-of-different-slicing-planes-in-preservation-of-major-hippocampal-pathway-fibers-in-the-mouse
#18
Guoxiang Xiong, Hannah Metheny, Brian N Johnson, Akiva S Cohen
The hippocampus plays a critical role in learning and memory and higher cognitive functions, and its dysfunction has been implicated in various neuropathological disorders. Electrophysiological recording undertaken in live brain slices is one of the most powerful tools for investigating hippocampal cellular and network activities. The plane for cutting the slices determines which afferent and/or efferent connections are best preserved, and there are three commonly used slices: hippocampal-entorhinal cortex (HEC), coronal and transverse...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29184706/cervical-intramedullary-spinal-cord-lipoma
#19
Rocco Severino, Paolo Severino
Background: Intramedullary, nondysraphic, spinal cord lipomas are rare and account for less than 1% of all spinal cord lesions. Symptoms typically consist of a progressive myelopathy associated with increasing degrees of paralysis (e.g., quadriparesis/plegia, paraparesis/plegia). Case Description: A 39-year-old male, without a history of spinal dysraphism, presented with a progressive spastic quadriparesis. This was attributed to magnetic resonance-documented large intramedullary cervical lipoma...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29172994/amiloride-does-not-protect-retinal-nerve-fibre-layer-thickness-in-optic-neuritis-in-a-phase-2-randomised-controlled-trial
#20
Justin B McKee, Charles L Cottriall, John Elston, Simon Epps, Nikos Evangelou, Stephen Gerry, Christopher Kennard, Yazhuo Kong, Abigail Koelewyn, Wilhelm Kueker, Maria Isabel Leite, Jacqueline Palace, Matthew Craner
BACKGROUND: Recent basic and clinical evidence suggests amiloride may be neuroprotective in multiple sclerosis (MS) through the blockade of the acid sensing ion channel (ASIC). OBJECTIVE: To examine the neuroprotective efficacy of amiloride in acute optic neuritis (ON). METHODS: A total of 48 patients were recruited to a phase 2, double blind, single site, randomised controlled trial. Scanning laser polarimetry (GDx) at 6 months was the primary outcome measure and optical coherence tomography (OCT) and visual and electrophysiological measures were secondary outcome measures...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
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