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Laser evoked potentials

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https://www.readbyqxmd.com/read/28527052/action-mechanisms-of-onabotulinum-toxin-a-hints-for-selection-of-eligible-patients
#1
Carlo Lovati, Luca Giani
In the past few decades, the so-feared botulinum toxin has conversely acquired the role of a ever more versatile therapeutic substance, used in an increasing number of pathological situations, including chronic headache and more precisely in the prophylaxis of chronic migraine. The medical use of botulinum toxin allowed to better understand its multiple mechanisms of action. Investigations about the pathophysiology of primary and secondary headaches has shown a series of common biological elements that frequently are also targets of the action of botulinum toxin...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28526914/finite-element-method-simulating-temperature-distribution-in-skin-induced-by-980-nm-pulsed-laser-based-on-pain-stimulation
#2
Han Wang, Xiao-Xi Dong, Ji-Chun Yang, He Huang, Ying-Xin Li, Hai-Xia Zhang
For predicting the temperature distribution within skin tissue in 980-nm laser-evoked potentials (LEPs) experiments, a five-layer finite element model (FEM-5) was constructed based on Pennes bio-heat conduction equation and the Lambert-Beer law. The prediction results of the FEM-5 model were verified by ex vivo pig skin and in vivo rat experiments. Thirty ex vivo pig skin samples were used to verify the temperature distribution predicted by the model. The output energy of the laser was 1.8, 3, and 4.4 J. The laser spot radius was 1 mm...
May 19, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28506878/pain-motor-integration-in-the-primary-motor-cortex-in-parkinson-s-disease
#3
A Suppa, C Leone, F Di Stasio, L Marsili, A Di Santo, A Biasiotta, S La Cesa, A Truini, G Cruccu, A Berardelli
BACKGROUND: In Parkinson's disease (PD), the influence of chronic pain on motor features has never been investigated. We have recently designed a technique that combines nociceptive system activation by laser stimuli and primary motor cortex (M1) activation through transcranial magnetic stimulation (TMS), in a laser-paired associative stimulation design (Laser-PAS). In controls, Laser-PAS induces long-term changes in motor evoked potentials reflecting M1 long-term potentiation-like plasticity, arising from pain-motor integration...
April 30, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28446584/the-human-primary-somatosensory-cortex-is-differentially-involved-in-vibrotaction-and-nociception
#4
Cédric Lenoir, Gan Huang, Yves Vandermeeren, Samar M Hatem, André Mouraux
The role of the primary somatosensory cortex (S1) in vibrotaction is well established. In contrast, its involvement in nociception remains debated. Here, we test whether S1 is similarly involved in the processing of non-nociceptive and nociceptive somatosensory input in humans by comparing the after-effects of high-definition transcranial direct current stimulation (HD-tDCS) of the primary sensorimotor cortex on the event-related potentials (ERPs) elicited by non-nociceptive and nociceptive somatosensory stimuli delivered to the ipsilateral and contralateral hand...
April 26, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28410768/-small-fiber-neuropathy
#5
V Langlois, A-L Bedat Millet, M Lebesnerais, S Miranda, F Marguet, Y Benhamou, P Marcorelles, H Lévesque
Small fiber neuropathy (SFN) is still unknown. Characterised by neuropathic pain, it typically begins by burning feet, but could take many other expression. SFN affects the thinly myelinated Aδ and unmyelinated C-fibers, by an inherited or acquired mechanism, which could lead to paresthesia, thermoalgic disorder or autonomic dysfunction. Recent studies suggest the preponderant role of ion channels such as Nav1.7. Furthermore, erythromelalgia or burning mouth syndrome are now recognized as real SFN. Various aetiologies of SFN are described...
April 11, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28326950/efficacy-of-the-topical-5-lidocaine-medicated-plaster-in-the-treatment-of-chronic-post-thoracotomy-neuropathic-pain
#6
Pasquale Sansone, Maria Beatrice Passavanti, Alfonso Fiorelli, Caterina Aurilio, Umberto Colella, Lorenzo De Nardis, Valerio Donatiello, Vincenzo Pota, Maria Caterina Pace
AIM: To assess the efficacy of the topical 5% lidocaine medicated plaster (Versatis(®), Grünenthal GmbH, Aachen, Germany) in patients with post-thoracotomy neuropathic pain. PATIENTS & METHODS: Patients were randomized to receive the topical 5% lidocaine medicated plaster (n = 33) or non-medicated placebo plasters (n = 30) for 12 h every day for 8 weeks. Laser-evoked potentials (LEPs) were measured, and various questionnaires/scales completed. RESULTS: Numeric Rating Scale pain scores improved significantly (p < 0...
March 3, 2017: Pain Management
https://www.readbyqxmd.com/read/28267059/diagnostic-accuracy-of-laser-evoked-potentials-in-diabetic-neuropathy
#7
Giulia Di Stefano, Silvia La Cesa, Caterina Leone, Alessia Pepe, Eleonora Galosi, Marco Fiorelli, Massimiliano Valeriani, Marco Lacerenza, Mario Pergolini, Antonella Biasiotta, Giorgio Cruccu, Andrea Truini
Although the most widely agreed neurophysiological tool for investigating small fiber damage is laser-evoked potential (LEP) recording, no study has documented its diagnostic accuracy. In this clinical, neurophysiological, and skin biopsy study, we collected age-corrected LEP normative ranges, verified the association of LEPs with pinprick sensory disturbances in the typical diabetic mixed fiber polyneuropathy, and assessed the sensitivity and specificity of LEPs in diabetic small fiber neuropathy. From 288 LEP recordings from the face, hand, and foot in 73 healthy subjects, we collected age-corrected normative ranges for LEPs...
June 2017: Pain
https://www.readbyqxmd.com/read/28207185/age-related-changes-in-laser-evoked-potentials-following-trigeminal-and-hand-stimulation-in-healthy-subjects
#8
M de Tommaso, K Ricci, A Montemurno, E Vecchio
OBJECTIVE: This study aimed to evaluate age-related changes in laser-evoked potential (LEP) features, including habituation, via trigeminal and hand stimulation in a large group of healthy volunteers. METHODS: We recorded the LEPs by right-hand stimulation in 237 healthy subjects and by stimulation of the right supraorbital zone in 170 cases. The subjects ranged in age from 7 to 72 years and were divided into six groups by age. RESULTS: At the trigeminal level, the N2 and P2 latencies were significantly shorter and the N2-P2 amplitude was significantly larger in the 7-17 age group than in the other groups...
February 16, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28204781/differences-in-pain-perception-between-men-and-women-of-reproductive-age-a-laser-evoked-potentials-study
#9
Chryssoula Staikou, Panagiotis Kokotis, Andreas Kyrozis, Demetrios Rallis, George Makrydakis, Dimitra Manoli, Nikolaos Karandreas, Elefterios Stamboulis, Christos Moschovos, Argyro Fassoulaki
No abstract text is available yet for this article.
February 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28187977/retinal-and-optic-nerve-degeneration-in-patients-with-multiple-sclerosis-followed-up-for-5-years
#10
Elena Garcia-Martin, Jose R Ara, Jesus Martin, Carmen Almarcegui, Isabel Dolz, Elisa Vilades, Laura Gil-Arribas, Francisco J Fernandez, Vicente Polo, Jose M Larrosa, Luis E Pablo, Maria Satue
PURPOSE: To quantify retinal nerve fiber layer (RNFL) changes in patients with multiple sclerosis (MS) and healthy controls with a 5-year follow-up and to analyze correlations between disability progression and RNFL degeneration. DESIGN: Observational and longitudinal study. PARTICIPANTS: One hundred patients with relapsing-remitting MS and 50 healthy controls. METHODS: All participants underwent a complete ophthalmic and electrophysiologic exploration and were re-evaluated annually for 5 years...
May 2017: Ophthalmology
https://www.readbyqxmd.com/read/28161015/-electrophysiological-testing-in-spinal-cord-tumors
#11
REVIEW
N André-Obadia, F Mauguière
Evoked potentials (EPs) are useful to evaluate the functional impairment of motor and somatosensory pathways in spinal cord tumors. Conduction through pyramidal tracts is evaluated by motor EPs (MEPs) elicited by transcranial stimulation, magnetic for awake patients or electric in the operating room. Somatosensory EPs (SEPs) and laser EPs (LEPs) are complementary procedures to explore conduction in dorsal columns and spinothalamic tracts, respectively. MEPs as well as SEPs show conduction abnormalities in about 60% of cases with a sensitivity that increases up to 70% when both procedures are carried out...
February 1, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28139023/investigation-of-the-predictive-validity-of-laser-eps-on-normal-uvb-and-capsaicin-irritated-skin-with-4-analgesic-compounds-in-healthy-volunteers
#12
Klaus Schaffler, Laurent B Nicolas, Andreas Borta, Tobias Brand, Peter Reitmeir, Robert Roebling, Joachim Scholpp
AIMS: To assess predictivity of laser-(radiant-heat)-evoked-potentials (LEPs) from vertex-EEG, as algesimetric procedure, testing anti-nociceptive/anti-hyperalgesic effects of single oral doses of 4 marketed analgesics (different compound classes) vs. placebo with healthy volunteers in 3 skin types. METHODS: This was a randomized, placebo-controlled, single-blind, 5-way-crossover trial. Twenty-five healthy female/male Caucasians were included (receiving celecoxib 200 mg, pregabalin 150 mg, duloxetine 60 mg, lacosamide 100 mg, placebo) in a Williams design with CO2 -laser-induced painful stimuli on normal, UVB-inflamed and capsaicin-irritated skin...
January 31, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28117333/usefulness-of-laser-evoked-potentials-and-quantitative-sensory-testing-in-the-diagnosis-of-neuropathic-spinal-cord-injury-pain-a-multiple-case-study
#13
G Landmann, M F Berger, L Stockinger, E Opsommer
STUDY DESIGN: A retrospective study. OBJECTIVES: The aim of this study was to investigate the contribution of laser-evoked potentials (LEPs) and quantitative sensory testing (QST) to the diagnosis of neuropathic pain in patients with spinal cord injury (SCI) and inconclusive magnetic resonance imaging (MRI) findings. SETTING: A multidisciplinary pain center. METHODS: QST (DFNS protocol) and Tm-YAG-laser stimulation of the skin were applied within the pain site corresponding with dermatomes of altered sensation...
January 24, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28114593/murine-autoimmune-optic-neuritis-is-not-phenotypically-altered-by-the-retinal-degeneration-8-mutation
#14
Aleksandar Stojic, Richard Fairless, Susanne C Beck, Vithiyanjali Sothilingam, Petra Weissgerber, Ulrich Wissenbach, Valerie Gimmy, Mathias W Seeliger, Veit Flockerzi, Ricarda Diem, Sarah K Williams
Purpose: To investigate whether the presence of the retinal degeneration 8 (rd8) mutation in C57BL/6 mice alters the phenotype of autoimmune optic neuritis (AON). Methods: C57BL/6J and C57BL/6N mice were genotyped for the rd8 mutation and fundus analyses and examination of retinal layer morphology were performed in vivo by scanning laser ophthalmoscopy and optical coherence tomography. Visual function was assessed by recording electroretinographs, and visual evoked potentials and retinae and optic nerves were assessed histopathologically...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28113296/pressure-in-the-cochlea-during-infrared-irradiation
#15
Nan Xia, Xiaodong Tan, Yingyue Xu, Wensheng Hou, Teresa Mao, Claus-Peter Richter
OBJECTIVE: The purpose of the study is to demonstrate laser evoked pressure waves in small confined volumes such as the cochlea. METHODS: Custom fabricated pressure probes were used to determine the pressure in front of the optical fiber in a small dish and patch pipettes to measure temperature changes. Pressure probes were inserted into scala tympani or vestibuli during laser stimulation. With a sensitive microphone the pressure was measured in the outer ear canal...
December 7, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28106318/reduced-laser-evoked-potential-habituation-detects-abnormal-central-pain-processing-in-painful-radiculopathy-patients
#16
P Hüllemann, C von der Brelie, G Manthey, J Düsterhöft, A K Helmers, M Synowitz, R Baron
BACKGROUND: Repetitive painful laser stimuli lead to physiological laser-evoked potential (LEP) habituation, measurable by a decrement of the N2/P2 amplitude. The time course of LEP-habituation is reduced in the capsaicin model for peripheral and central sensitization and in patients with migraine and fibromyalgia. In the present investigation, we aimed to assess the time course of LEP-habituation in a neuropathic pain syndrome, i.e. painful radiculopathy. METHODS: At the side of radiating pain, four blocks of 25 painful laser stimuli each were applied to the ventral thigh at the L3 dermatome in 27 patients with painful radiculopathy...
May 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28080967/affective-touch-and-attachment-style-modulate-pain-a-laser-evoked-potentials-study
#17
Charlotte Krahé, Marianne M Drabek, Yannis Paloyelis, Aikaterini Fotopoulou
Affective touch and cutaneous pain are two sub-modalities of interoception with contrasting affective qualities (pleasantness/unpleasantness) and social meanings (care/harm), yet their direct relationship has not been investigated. In 50 women, taking into account individual attachment styles, we assessed the role of affective touch and particularly the contribution of the C tactile (CT) system in subjective and electrophysiological responses to noxious skin stimulation, namely N1 and N2-P2 laser-evoked potentials...
November 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27995385/effect-of-shorter-pulse-duration-in-cochlear-neural-activation-with-an-810-nm-near-infrared-laser
#18
Jingxuan Wang, Lan Tian, Jianren Lu, Ming Xia, Ying Wei
Optical neural stimulation in the cochlea has been presented as an alternative technique to the electrical stimulation due to its potential in spatially selectivity enhancement. So far, few studies have selected the near-infrared (NIR) laser in cochlear neural stimulation and limited optical parameter space has been examined. This paper focused on investigating the optical parameter effect on NIR stimulation of auditory neurons, especially under shorter pulse durations. The spiral ganglion neurons in the cochlea of deafened guinea pigs were stimulated with a pulsed 810-nm NIR laser in vivo...
February 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/27965587/exploring-the-mechanisms-of-exercise-induced-hypoalgesia-using-somatosensory-and-laser-evoked-potentials
#19
Matthew D Jones, Janet L Taylor, John Booth, Benjamin K Barry
Exercise-induced hypoalgesia is well described, but the underlying mechanisms are unclear. The aim of this study was to examine the effect of exercise on somatosensory evoked potentials, laser evoked potentials, pressure pain thresholds and heat pain thresholds. These were recorded before and after 3-min of isometric elbow flexion exercise at 40% of the participant's maximal voluntary force, or an equivalent period of rest. Exercise-induced hypoalgesia was confirmed in two experiments (Experiment 1-SEPs; Experiment 2-LEPs) by increased pressure pain thresholds at biceps brachii (24...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27959792/pressure-in-the-cochlea-during-infrared-irradiation
#20
Nan Xia, Xiaodong Tan, Yingyue Xu, Wensheng Hou, Teresa Mao, Claus-Peter Richter
OBJECTIVE: The purpose of the study is to demonstrate laser evoked pressure waves in small confined volumes such as the cochlea. METHODS: Custom fabricated pressure probes were used to determine the pressure in front of the optical fiber in a small dish and patch pipettes to measure temperature changes. Pressure probes were inserted into scala tympani or vestibuli during laser stimulation. With a sensitive microphone the pressure was measured in the outer ear canal...
December 7, 2016: IEEE Transactions on Bio-medical Engineering
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