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Laser evoked potentials

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https://www.readbyqxmd.com/read/27906239/fiber-optic-electron-spin-resonance-thermometry-of-single-laser-activated-neurons
#1
A A Lanin, I V Fedotov, Yu G Ermakova, D A Sidorov-Biryukov, A B Fedotov, P Hemmer, V V Belousov, A M Zheltikov
Optically detected electron spin resonance in fiber-coupled nitrogen-vacancy (NV) centers of diamond is used to demonstrate a fiber-optic quantum thermometry of individual thermogenetically activated neurons. Laser-induced temperature variations read out from single neurons with the NV-diamond fiber sensor are shown to strongly correlate with the fluorescence of calcium-ion sensors, serving as online indicators of the inward Ca<sup>2+</sup> current across the cell membrane of neurons expressing transient receptor potential (TRP) cation channels...
December 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27896311/interfacing-with-neural-activity-via-femtosecond-laser-stimulation-of-drug-encapsulating-liposomal-nanostructures
#2
Takashi Nakano, Sean M Mackay, Eng Wui Tan, Keshav M Dani, Jeff Wickens
External control over rapid and precise release of chemicals in the brain potentially provides a powerful interface with neural activity. Optical manipulation techniques, such as optogenetics and caged compounds, enable remote control of neural activity and behavior with fine spatiotemporal resolution. However, these methods are limited to chemicals that are naturally present in the brain or chemically suitable for caging. Here, we demonstrate the ability to interface with neural functioning via a wide range of neurochemicals released by stimulating loaded liposomal nanostructures with femtosecond lasers...
November 2016: ENeuro
https://www.readbyqxmd.com/read/27836714/abnormal-nociceptive-processing-occurs-centrally-and-not-peripherally-in-pain-free-parkinson-disease-patients-a-study-with-laser-evoked-potentials
#3
Sandro Zambito-Marsala, Roberto Erro, Ruggero Bacchin, Annalisa Fornasier, Federico Fabris, Cecilia Lo Cascio, Franco Ferracci, Francesca Morgante, Michele Tinazzi
BACKGROUND: Several studies documented abnormal nociceptive processing in PD patients. Pain central pathways are accessible by laser-evoked potentials (LEPs). LEPs recording show a N2/P2 complex mostly generated by the anterior cingulate cortex, preceded by an earlier negative component (N1), originating from the opercular cortex. Previous work demonstrated N2/P2 amplitude reduction in PD patients and suggested a centrally-acting pathomechanism for the genesis of pain. However, since a peripheral deafferentation has been recently demonstrated in PD, it is not clear if such LEP abnormalities reflect a mechanism acting centrally or not...
October 24, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27803649/two-photon-holographic-stimulation-of-reachr
#4
Emmanuelle Chaigneau, Emiliano Ronzitti, Marta A Gajowa, Gilberto J Soler-Llavina, Dimitrii Tanese, Anthony Y B Brureau, Eirini Papagiakoumou, Hongkui Zeng, Valentina Emiliani
Optogenetics provides a unique approach to remotely manipulate brain activity with light. Reaching the degree of spatiotemporal control necessary to dissect the role of individual cells in neuronal networks, some of which reside deep in the brain, requires joint progress in opsin engineering and light sculpting methods. Here we investigate for the first time two-photon stimulation of the red-shifted opsin ReaChR. We use two-photon (2P) holographic illumination to control the activation of individually chosen neurons expressing ReaChR in acute brain slices...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27782355/pain-processing-abnormalities-in-bipolar-i-disorder-bipolar-ii-disorder-and-schizophrenia-a-novel-trait-marker-for-psychosis-proneness-and-functional-outcome
#5
Amedeo Minichino, Roberto Delle Chiaie, Giorgio Cruccu, Serena Piroso, Giulia Di Stefano, Marta Francesconi, Francesco Saverio Bersani, Massimo Biondi, Andrea Truini
OBJECTIVES: Overlapping neural system dysfunctions, mainly involving the secondary somatosensory cortex (S2), the anterior cingulate cortex (ACC) and the anterior insular cortex (AIC), seem to be related to both pain-perception abnormalities and psychotic symptoms in schizophrenia (SCZ) and bipolar disorder (BD). Laser-evoked potentials (LEPs) were used to investigate pain-perception and central pain-processing abnormalities in SCZ, bipolar I disorder (BD-I), and bipolar II disorder (BD-II), and to evaluate their relationship with history of psychosis, and social-cognitive and functional impairments...
November 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27776990/functional-characterization-of-at-level-hypersensitivity-in-patients-with-spinal-cord-injury
#6
Carola Vogel, Roman Rukwied, Lenka Stockinger, Marcus Schley, Martin Schmelz, Wolfgang Schleinzer, Christoph Konrad
: At-level and above-level hypersensitivity was assessed in patients with chronic complete thoracic spinal cord injury (SCI). Patients were classified using somatosensory mapping (brush, cold, pinprick) and assigned into 2 groups (ie, patients with at-level hypersensitivity [SCIHs, n = 8] and without at-level hypersensitivity [SCINHs, n = 7]). Gender and age-matched healthy subjects served as controls. Quantitative sensory testing (QST), electrically- and histamine-induced pain and itch, laser Doppler imaging, and laser-evoked potentials (LEP) were recorded at-level and above-level in SCI-patients...
October 22, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27740600/disorders-of-consciousness-painless-or-painful-conditions-evidence-from-neuroimaging-studies
#7
Francesca Pistoia, Simona Sacco, Janet Stewart, Marco Sarà, Antonio Carolei
The experience of pain in disorders of consciousness is still debated. Neuroimaging studies, using functional Magnetic Resonance Imaging (fMRI), Positron Emission Tomography (PET), multichannel electroencephalography (EEG) and laser-evoked potentials, suggest that the perception of pain increases with the level of consciousness. Brain activation in response to noxious stimuli has been observed in patients with unresponsive wakefulness syndrome (UWS), which is also referred to as a vegetative state (VS), as well as those in a minimally conscious state (MCS)...
October 8, 2016: Brain Sciences
https://www.readbyqxmd.com/read/27589067/laser-and-somatosensory-evoked-potentials-in-amyotrophic-lateral-sclerosis
#8
Baris Isak, Hatice Tankisi, Birger Johnsen, Kirsten Pugdahl, Nanna Brix Finnerup, Anders Fuglsang-Frederiksen
OBJECTIVE: Mild involvement of sensory nerves has been reported in previous studies in ALS patients. In this study, we assessed sensory pathways in ALS patients using laser evoked potentials (LEPs) and somatosensory evoked potentials (SSEPs). METHODS: We recruited 18 ALS patients and 31 healthy subjects. Neodymium-doped yttrium aluminium perovskite (Nd:YAP)-laser was used to evoke LEPs in upper (UE) and lower (LE) extremities. N1 and N2P2 potentials were obtained from contralateral insular cortex (T3 or T4) and vertex (Cz), respectively...
October 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27568204/postnatal-changes-in-glutamatergic-inputs-of-jaw-closing-motoneuron-dendrites
#9
Shoko Nagata, Shiro Nakamura, Kiyomi Nakayama, Ayako Mochizuki, Matsuo Yamamoto, Tomio Inoue
Dendrites of masseter (jaw-closing) motoneurons (MMNs) are well developed and ramify extensively throughout the trigeminal motor nucleus and often extend into the adjacent reticular formation. It is possible that the dendrites have active properties, which are altered with the development of the orofacial musculoskeletal system. Thus, we examined the changes in somatic voltage responses evoked by photostimulation of the MMN dendrites by laser photolysis of caged glutamate from postnatal day (P) 2-5 and 9-12 rats...
August 24, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27522962/monosodium-glutamate-alters-the-response-properties-of-rat-trigeminovascular-neurons-through-activation-of-peripheral-nmda-receptors
#10
Melissa O'Brien, Brian E Cairns
Ingestion of monosodium glutamate (MSG) has been shown to cause headaches in healthy individuals and trigger migraine-like headaches in migraine sufferers. We combined immunohistochemistry, in vivo electrophysiology, and laser Doppler recordings of dural vasculature to investigate the effect of systemic administration of MSG on the trigeminovascular pathway. Immunohistochemical analysis confirmed the expression of NMDA receptors on nerve fibres innervating dural blood vessels and excitatory amino acid transporter 2 on dural blood vessels...
August 11, 2016: Neuroscience
https://www.readbyqxmd.com/read/27517089/lsps-optogenetics-to-improve-synaptic-connectivity-mapping-unmasking-the-role-of-basket-cell-mediated-feedforward-inhibition
#11
Julia Brill, Joanna Mattis, Karl Deisseroth, John R Huguenard
Neocortical pyramidal cells (PYRs) receive synaptic inputs from many types of GABAergic interneurons. Connections between parvalbumin (PV)-positive, fast-spiking interneurons ("PV cells") and PYRs are characterized by perisomatic synapses and high-amplitude, short-latency IPSCs. Here, we present novel methods to study the functional influence of PV cells on layer 5 PYRs using optogenetics combined with laser-scanning photostimulation (LSPS). First, we examined the strength and spatial distribution of PV-to-PYR inputs...
July 2016: ENeuro
https://www.readbyqxmd.com/read/27473631/differences-in-pain-perception-between-men-and-women-of-reproductive-age-a-laser-evoked-potentials-study
#12
Chryssoula Staikou, Panagiotis Kokotis, Andreas Kyrozis, Demetrios Rallis, George Makrydakis, Dimitra Manoli, Nikolaos Karandreas, Elefterios Stamboulis, Christos Moschovos, Argyro Fassoulaki
OBJECTIVE: We investigated differences in pain perception between men and women of reproductive age by using Laser-Evoked Potentials (LEPs). DESIGN, SETTING, SUBJECTS: Forty-four right-handed healthy volunteers (19 males/25 females), aged 30-40 years were studied. A CO2 laser generated three series of 10 thermal pulses (4.5 W) on the radial aspect of the dorsum of the left hand. A recording montage for late LEPs was used, and the potentials of each series of stimuli were averaged to calculate mean latency and amplitude for each subject...
July 29, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27465406/functional-and-structural-assessment-of-patients-with-and-without-persistent-pain-after-thoracotomy
#13
J S Springer, P Karlsson, C S Madsen, B Johnsen, N B Finnerup, T S Jensen, L Nikolajsen
BACKGROUND: Persistent pain is frequent after thoracotomy, with a reported prevalence of up to 60%. It remains unclear why some patients develop pain, whereas others do not. We therefore examined patients with and without pain after thoracotomy to identify pathophysiological contributors to persistent pain. METHODS: Twenty patients with persistent pain, 12 patients without pain and 20 healthy controls underwent detailed functional and structural assessment including psychometric and neuropathic pain questionnaires, bedside examination for pinprick hyperalgesia and brush allodynia, quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain, measurement of capsaicin-evoked flare response, intradermal nerve density as determined by skin biopsies and laser- and heat-evoked potentials...
July 28, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27461877/expectation-to-feel-more-pain-disrupts-the-habituation-of-laser-pain-rating-and-laser-evoked-potential-amplitudes
#14
Costanza Pazzaglia, Elisa Testani, Rocco Giordano, Luca Padua, Massimiliano Valeriani
Increased pain perception due to the expectation to feel more pain is called nocebo effect. The present study aimed at investigating whether: (1) the mere expectation to feel more pain after the administration of an inert drug can affect the laser-pain rating and the laser-evoked potential (LEP) amplitude, and (2) the learning potentiates the nocebo effect. Eighteen healthy volunteers were told that an inert cream, applied on the right hand, would increase the laser pain and LEP amplitude to right hand stimulation...
October 1, 2016: Neuroscience
https://www.readbyqxmd.com/read/27419217/nociceptive-evoked-potentials-are-sensitive-to-behaviorally-relevant-stimulus-displacements-in-egocentric-coordinates
#15
M Moayedi, G Di Stefano, M T Stubbs, B Djeugam, M Liang, G D Iannetti
Feature selection has been extensively studied in the context of goal-directed behavior, where it is heavily driven by top-down factors. A more primitive version of this function is the detection of bottom-up changes in stimulus features in the environment. Indeed, the nervous system is tuned to detect fast-rising, intense stimuli that are likely to reflect threats, such as nociceptive somatosensory stimuli. These stimuli elicit large brain potentials maximal at the scalp vertex. When elicited by nociceptive laser stimuli, these responses are labeled laser-evoked potentials (LEPs)...
May 2016: ENeuro
https://www.readbyqxmd.com/read/27389122/functional-reorganization-of-the-primary-somatosensory-cortex-of-a-phantom-limb-pain-patient
#16
Jia Zhao, Xiaoli Guo, Xiaolei Xia, Weiwei Peng, Wuchao Wang, Shulin Li, Ya Zhang, Li Hu
Functional reorganization of the somatosensory system was widely observed in phantom limb pain patients. Whereas some studies demonstrated that the primary somatosensory cortex (S1) of the amputated limb was engaged with the regions around it, others showed that phantom limb pain was associated with preserved structure and functional organization in the former brain region. However, according to the law of use and disuse, the sensitivity of S1 of the amputated limb to pain-related context should be enhanced due to the adaptation to the long-lasting phantom limb pain experience...
July 2016: Pain Physician
https://www.readbyqxmd.com/read/27350217/nefopam-a-non-opioid-analgesic-does-not-alleviate-experimental-work-effort-dyspnoea-in-healthy-humans-a-randomised-controlled-trial
#17
Laurence Dangers, Louis Laviolette, Bény Charbit, Thomas Similowski, Capucine Morélot-Panzini
BACKGROUND: Dyspnoea is a distressing and debilitating symptom with a major impact on quality of life. Alleviation of dyspnoea therefore constitutes a major clinical challenge. When causative physiological disorders cannot be corrected ("persistent dyspnoea"), nonspecific treatment must be considered. Morphine alleviates dyspnoea but has numerous side-effects including ventilatory depression, which justifies looking for alternatives. Certain forms of dyspnoea involve C-fibres, and can be attenuated by C-fibres blockade...
August 2016: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27314908/activity-dependent-calcium-oxygen-and-vascular-responses-in-a-mouse-model-of-familial-hemiplegic-migraine-type-1
#18
Lila Khennouf, Bodil Gesslein, Barbara Lykke Lind, Arn M J M van den Maagdenberg, Martin Lauritzen
OBJECTIVE: Familial hemiplegic migraine type 1 (FHM1) is a subtype of migraine with aura caused by a gain-of-function mutation in the pore-forming α1 subunit of CaV 2.1 (P/Q-type) calcium channels. However, the mechanisms underlying how the disease is brought about and the prolonged aura remain incompletely understood. METHODS: In the anesthetized FHM1 mouse model in vivo, we used two-photon microscopy to measure calcium changes in neurons and astrocytes during somatosensory stimulations and cortical spreading depression (CSD), the putative mechanism of the migraine aura...
August 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27269303/damage-criteria-for-cerebral-cortex-cells-subjected-to-hyperthermia
#19
Rickard Liljemalm, Tobias Nyberg
Temperatures above the normal physiological threshold may cause damage to cells and tissue. In this study, the response of a culture of dissociated cerebral cortex cells exposed to laser-induced temperature gradients was examined. The cellular response was evaluated using a fluorescent dye indicating metabolic activity. Furthermore, by using a finite element model of the heating during the pulsed laser application, threshold temperatures could be extracted for the cellular response at different laser pulse lengths...
September 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27251170/role-of-capsaicin-sensitive-nerves-and-tachykinins-in-mast-cell-tryptase-induced-inflammation-of-murine-knees
#20
Éva Borbély, Katalin Sándor, Adrienn Markovics, Ágnes Kemény, Erika Pintér, János Szolcsányi, John P Quinn, Jason J McDougall, Zsuzsanna Helyes
OBJECTIVE, DESIGN: Mast cell tryptase (MCT) is elevated in arthritic joints, but its direct effects are not known. Here, we investigated MCT-evoked acute inflammatory and nociceptive mechanisms with behavioural, in vivo imaging and immunological techniques. MATERIAL AND SUBJECTS: Neurogenic inflammation involving capsaicin-sensitive afferents, transient receptor potential vanilloid 1 receptor (TRPV1), substance P (SP), neurokinin A (NKA) and their NK1 tachykinin receptor were studied using gene-deleted mice compared to C57Bl/6 wildtypes (n = 5-8/group)...
September 2016: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
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