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Laser evoked potentials

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https://www.readbyqxmd.com/read/28803174/intraoperative-vascular-neuromonitoring-in-patients-with-subarachnoid-hemorrhage-a-pilot-study-using-combined-laser-doppler-spectrophotometry
#1
Emilija Schmitz, Barbara Bischoff, Dennis Wolf, Hubert Schmitt, Ilker Y Eyupoglu, Karl Roessler, Michael Buchfelder, Björn Sommer
OBJECTIVE: Intraoperative monitoring of cerebral microcirculation in patients with subarachnoid hemorrhage (SAH) may predict the postoperative neurological outcome. In this pilot study, we examined the value of a novel non-invasive real-time measurement technique to detect changes in local microcirculation. METHODS: We used the laser-Doppler spectrophotometry system "Oxygen-to-see(O2C)" in 14 patients with SAH Hunt & Hess grade 2 to 5, who underwent microsurgical clipping of cerebral aneurysms...
August 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28752263/photobiomodulation-therapy-by-nir-laser-in-persistent-pain-an-analytical-study-in-the-rat
#2
Laura Micheli, Lorenzo Di Cesare Mannelli, Elena Lucarini, Francesca Cialdai, Leonardo Vignali, Carla Ghelardini, Monica Monici
Over the past three decades, physicians have used laser sources for the management of different pain conditions obtaining controversial results that call for further investigations. In order to evaluate the pain relieving possibilities of photobiomodulation therapy (PBMT), we tested two near infrared (NIR) laser systems, with different power, against various kinds of persistent hyperalgesia animal models. In rats, articular pain was reproduced by the intra-articular injection of sodium monoiodoacetate (MIA) and complete Freund's adjuvant (CFA), while compressive neuropathy was modelled by the chronic constriction injury of the sciatic nerve (CCI)...
July 28, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28744201/calcium-dynamics-in-basal-dendrites-of-layer-5a-and-5b-pyramidal-neurons-is-tuned-to-the-cell-type-specific-physiological-action-potential-discharge
#3
Patrik Krieger, Christiaan P J de Kock, Andreas Frick
Layer 5 (L5) is a major neocortical output layer containing L5A slender-tufted (L5A-st) and L5B thick-tufted (L5B-tt) pyramidal neurons. These neuron types differ in their in vivo firing patterns, connectivity and dendritic morphology amongst other features, reflecting their specific functional role within the neocortical circuits. Here, we asked whether the active properties of the basal dendrites that receive the great majority of synaptic inputs within L5 differ between these two pyramidal neuron classes...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28665973/negative-expectations-interfere-with-the-analgesic-effect-of-safety-cues-on-pain-perception-by-priming-the-cortical-representation-of-pain-in-the-midcingulate-cortex
#4
Abeer F Almarzouki, Christopher A Brown, Richard J Brown, Matthew H K Leung, Anthony K P Jones
It is well known that the efficacy of treatment effects, including those of placebos, is heavily dependent on positive expectations regarding treatment outcomes. For example, positive expectations about pain treatments are essential for pain reduction. Such positive expectations not only depend on the properties of the treatment itself, but also on the context in which the treatment is presented. However, it is not clear how the preceding threat of pain will bias positive expectancy effects. One hypothesis is that threatening contexts trigger fearful and catastrophic thinking, reducing the pain-relieving effects of positive expectancy...
2017: PloS One
https://www.readbyqxmd.com/read/28614189/dose-response-study-of-topical-allyl-isothiocyanate-mustard-oil-as-a-human-surrogate-model-of-pain-hyperalgesia-and-neurogenic-inflammation
#5
Hjalte H Andersen, Silvia Lo Vecchio, Parisa Gazerani, Lars Arendt-Nielsen
Despite being a ubiquitous animal pain model, the natural TRPA1-agonist allyl isothiocyanate (AITC, also known as "mustard oil") has only been sparsely investigated as a potential human surrogate model of pain, sensitization, and neurogenic inflammation. Its dose-response as an algogenic, sensitizing irritant remains to be elucidated in human skin. Three concentrations of AITC (10%, 50%, and 90%) and vehicle (paraffin) were applied for 5 minutes to 3 × 3 cm areas on the volar forearms in 14 healthy volunteers, and evoked pain intensity (visual analog scale 0-100 mm) and pain quality were assessed...
September 2017: Pain
https://www.readbyqxmd.com/read/28533761/the-frontal-area-with-higher-frequency-response-is-the-principal-feature-of-laser-evoked-potentials-in-rats-with-chronic-inflammatory-pain-a-parallel-factor-analysis-study
#6
Jing Wang, Juan Wang, You Wan, Xiaoli Li
Chronic pain is a pathological developing course of pain. In clinic, an objective indicator is needed for diagnosing and better controlling chronic pain. The abnormal neural responses in chronic pain are reflected by multiple event-related potentials (ERPs) in time, frequency, and location domain, respectively. However, multiple changes in ERPs are not applicable in clinic. So, the principal feature covered the most informative changes extracted from these three domains of ERP during the development of chronic pain is needed...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28527052/action-mechanisms-of-onabotulinum-toxin-a-hints-for-selection-of-eligible-patients
#7
Carlo Lovati, Luca Giani
In the past few decades, the so-feared botulinum toxin has conversely acquired the role of a ever more versatile therapeutic substance, used in an increasing number of pathological situations, including chronic headache and more precisely in the prophylaxis of chronic migraine. The medical use of botulinum toxin allowed to better understand its multiple mechanisms of action. Investigations about the pathophysiology of primary and secondary headaches has shown a series of common biological elements that frequently are also targets of the action of botulinum toxin...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28526914/finite-element-method-simulating-temperature-distribution-in-skin-induced-by-980-nm-pulsed-laser-based-on-pain-stimulation
#8
Han Wang, Xiao-Xi Dong, Ji-Chun Yang, He Huang, Ying-Xin Li, Hai-Xia Zhang
For predicting the temperature distribution within skin tissue in 980-nm laser-evoked potentials (LEPs) experiments, a five-layer finite element model (FEM-5) was constructed based on Pennes bio-heat conduction equation and the Lambert-Beer law. The prediction results of the FEM-5 model were verified by ex vivo pig skin and in vivo rat experiments. Thirty ex vivo pig skin samples were used to verify the temperature distribution predicted by the model. The output energy of the laser was 1.8, 3, and 4.4 J. The laser spot radius was 1 mm...
May 19, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28506878/pain-motor-integration-in-the-primary-motor-cortex-in-parkinson-s-disease
#9
A Suppa, C Leone, F Di Stasio, L Marsili, A Di Santo, A Biasiotta, S La Cesa, A Truini, G Cruccu, A Berardelli
BACKGROUND: In Parkinson's disease (PD), the influence of chronic pain on motor features has never been investigated. We have recently designed a technique that combines nociceptive system activation by laser stimuli and primary motor cortex (M1) activation through transcranial magnetic stimulation (TMS), in a laser-paired associative stimulation design (Laser-PAS). In controls, Laser-PAS induces long-term changes in motor evoked potentials reflecting M1 long-term potentiation-like plasticity, arising from pain-motor integration...
July 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28446584/human-primary-somatosensory-cortex-is-differentially-involved-in-vibrotaction-and-nociception
#10
Cédric Lenoir, Gan Huang, Yves Vandermeeren, Samar Marie Hatem, André Mouraux
The role of the primary somatosensory cortex (S1) in vibrotaction is well established. In contrast, its involvement in nociception is still debated. Here we test whether S1 is similarly involved in the processing of nonnociceptive and nociceptive somatosensory input in humans by comparing the aftereffects of high-definition transcranial direct current stimulation (HD-tDCS) of S1 on the event-related potentials (ERPs) elicited by nonnociceptive and nociceptive somatosensory stimuli delivered to the ipsilateral and contralateral hands...
July 1, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28410768/-small-fiber-neuropathy
#11
V Langlois, A-L Bedat Millet, M Lebesnerais, S Miranda, F Marguet, Y Benhamou, P Marcorelles, H Lévesque
Small fiber neuropathy (SFN) is still unknown. Characterised by neuropathic pain, it typically begins by burning feet, but could take many other expression. SFN affects the thinly myelinated Aδ and unmyelinated C-fibers, by an inherited or acquired mechanism, which could lead to paresthesia, thermoalgic disorder or autonomic dysfunction. Recent studies suggest the preponderant role of ion channels such as Nav1.7. Furthermore, erythromelalgia or burning mouth syndrome are now recognized as real SFN. Various aetiologies of SFN are described...
April 11, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28326950/efficacy-of-the-topical-5-lidocaine-medicated-plaster-in-the-treatment-of-chronic-post-thoracotomy-neuropathic-pain
#12
Pasquale Sansone, Maria Beatrice Passavanti, Alfonso Fiorelli, Caterina Aurilio, Umberto Colella, Lorenzo De Nardis, Valerio Donatiello, Vincenzo Pota, Maria Caterina Pace
AIM: To assess the efficacy of the topical 5% lidocaine medicated plaster (Versatis(®), Grünenthal GmbH, Aachen, Germany) in patients with post-thoracotomy neuropathic pain. PATIENTS & METHODS: Patients were randomized to receive the topical 5% lidocaine medicated plaster (n = 33) or non-medicated placebo plasters (n = 30) for 12 h every day for 8 weeks. Laser-evoked potentials (LEPs) were measured, and various questionnaires/scales completed. RESULTS: Numeric Rating Scale pain scores improved significantly (p < 0...
May 2017: Pain Management
https://www.readbyqxmd.com/read/28267059/diagnostic-accuracy-of-laser-evoked-potentials-in-diabetic-neuropathy
#13
Giulia Di Stefano, Silvia La Cesa, Caterina Leone, Alessia Pepe, Eleonora Galosi, Marco Fiorelli, Massimiliano Valeriani, Marco Lacerenza, Mario Pergolini, Antonella Biasiotta, Giorgio Cruccu, Andrea Truini
Although the most widely agreed neurophysiological tool for investigating small fiber damage is laser-evoked potential (LEP) recording, no study has documented its diagnostic accuracy. In this clinical, neurophysiological, and skin biopsy study, we collected age-corrected LEP normative ranges, verified the association of LEPs with pinprick sensory disturbances in the typical diabetic mixed fiber polyneuropathy, and assessed the sensitivity and specificity of LEPs in diabetic small fiber neuropathy. From 288 LEP recordings from the face, hand, and foot in 73 healthy subjects, we collected age-corrected normative ranges for LEPs...
June 2017: Pain
https://www.readbyqxmd.com/read/28207185/age-related-changes-in-laser-evoked-potentials-following-trigeminal-and-hand-stimulation-in-healthy-subjects
#14
M de Tommaso, K Ricci, A Montemurno, E Vecchio
OBJECTIVE: This study aimed to evaluate age-related changes in laser-evoked potential (LEP) features, including habituation, via trigeminal and hand stimulation in a large group of healthy volunteers. METHODS: We recorded the LEPs by right-hand stimulation in 237 healthy subjects and by stimulation of the right supraorbital zone in 170 cases. The subjects ranged in age from 7 to 72 years and were divided into six groups by age. RESULTS: At the trigeminal level, the N2 and P2 latencies were significantly shorter and the N2-P2 amplitude was significantly larger in the 7-17 age group than in the other groups...
February 16, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28204781/differences-in-pain-perception-between-men-and-women-of-reproductive-age-a-laser-evoked-potentials-study
#15
Chryssoula Staikou, Panagiotis Kokotis, Andreas Kyrozis, Demetrios Rallis, George Makrydakis, Dimitra Manoli, Nikolaos Karandreas, Elefterios Stamboulis, Christos Moschovos, Argyro Fassoulaki
Objective: We investigated differences in pain perception between men and women of reproductive age by using Laser-Evoked Potentials (LEPs). Design, Setting, Subjects: Forty-four right-handed healthy volunteers (19 males/25 females), aged 30–40 years were studied. A CO2 laser generated three series of 10 thermal pulses (4.5 W) on the radial aspect of the dorsum of the left hand. A recording montage for late LEPs was used, and the potentials of each series of stimuli were averaged to calculate mean latency and amplitude for each subject...
February 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28187977/retinal-and-optic-nerve-degeneration-in-patients-with-multiple-sclerosis-followed-up-for-5-years
#16
Elena Garcia-Martin, Jose R Ara, Jesus Martin, Carmen Almarcegui, Isabel Dolz, Elisa Vilades, Laura Gil-Arribas, Francisco J Fernandez, Vicente Polo, Jose M Larrosa, Luis E Pablo, Maria Satue
PURPOSE: To quantify retinal nerve fiber layer (RNFL) changes in patients with multiple sclerosis (MS) and healthy controls with a 5-year follow-up and to analyze correlations between disability progression and RNFL degeneration. DESIGN: Observational and longitudinal study. PARTICIPANTS: One hundred patients with relapsing-remitting MS and 50 healthy controls. METHODS: All participants underwent a complete ophthalmic and electrophysiologic exploration and were re-evaluated annually for 5 years...
May 2017: Ophthalmology
https://www.readbyqxmd.com/read/28161015/-electrophysiological-testing-in-spinal-cord-tumors
#17
REVIEW
N André-Obadia, F Mauguière
Evoked potentials (EPs) are useful to evaluate the functional impairment of motor and somatosensory pathways in spinal cord tumors. Conduction through pyramidal tracts is evaluated by motor EPs (MEPs) elicited by transcranial stimulation, magnetic for awake patients or electric in the operating room. Somatosensory EPs (SEPs) and laser EPs (LEPs) are complementary procedures to explore conduction in dorsal columns and spinothalamic tracts, respectively. MEPs as well as SEPs show conduction abnormalities in about 60% of cases with a sensitivity that increases up to 70% when both procedures are carried out...
February 1, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28139023/investigation-of-the-predictive-validity-of-laser-eps-in-normal-uvb-inflamed-and-capsaicin-irritated-skin-with-four-analgesic-compounds-in-healthy-volunteers
#18
Klaus Schaffler, Laurent B Nicolas, Andreas Borta, Tobias Brand, Peter Reitmeir, Robert Roebling, Joachim Scholpp
AIMS: The aim of the present study was to assess the predictivity of laser-(radiant-heat)-evoked potentials (LEPs) from the vertex electroencephalogram, using an algesimetric procedure, testing the anti-nociceptive/anti-hyperalgesic effects of single oral doses of four marketed analgesics (of different compound classes) vs. placebo, in healthy volunteers with three skin types. METHODS: This was a randomized, placebo-controlled, single-blind, five-way-crossover trial...
July 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28117333/usefulness-of-laser-evoked-potentials-and-quantitative-sensory-testing-in-the-diagnosis-of-neuropathic-spinal-cord-injury-pain-a-multiple-case-study
#19
G Landmann, M F Berger, L Stockinger, E Opsommer
STUDY DESIGN: A retrospective study. OBJECTIVES: The aim of this study was to investigate the contribution of laser-evoked potentials (LEPs) and quantitative sensory testing (QST) to the diagnosis of neuropathic pain in patients with spinal cord injury (SCI) and inconclusive magnetic resonance imaging (MRI) findings. SETTING: A multidisciplinary pain center. METHODS: QST (DFNS protocol) and Tm-YAG-laser stimulation of the skin were applied within the pain site corresponding with dermatomes of altered sensation...
June 2017: Spinal Cord
https://www.readbyqxmd.com/read/28114593/murine-autoimmune-optic-neuritis-is-not-phenotypically-altered-by-the-retinal-degeneration-8-mutation
#20
Aleksandar Stojic, Richard Fairless, Susanne C Beck, Vithiyanjali Sothilingam, Petra Weissgerber, Ulrich Wissenbach, Valerie Gimmy, Mathias W Seeliger, Veit Flockerzi, Ricarda Diem, Sarah K Williams
Purpose: To investigate whether the presence of the retinal degeneration 8 (rd8) mutation in C57BL/6 mice alters the phenotype of autoimmune optic neuritis (AON). Methods: C57BL/6J and C57BL/6N mice were genotyped for the rd8 mutation and fundus analyses and examination of retinal layer morphology were performed in vivo by scanning laser ophthalmoscopy and optical coherence tomography. Visual function was assessed by recording electroretinographs, and visual evoked potentials and retinae and optic nerves were assessed histopathologically...
January 1, 2017: Investigative Ophthalmology & Visual Science
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