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https://www.readbyqxmd.com/read/29656566/absence-of-human-skin-irritation-and-allergenic-potential-after-repeated-patch-applications-of-a-lamellar-moisturizer
#1
Stephanie J Nisbet
BACKGROUND: New cosmetic products should undergo clinical evaluation for skin sensitization potential. OBJECTIVES: To assess the irritation and sensitization potential of a moisturizer containing lamellar structured lipids after repeated patch application in humans, using human repeated insult patch test methodology. METHODS: This 6-week, single-center, open-label study compared a lamellar moisturizer with negative saline control in human subjects aged 18-70 years and skin phototype (Fitzpatrick) classification I-IV...
April 15, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29655589/emerging-applications-of-eye-tracking-technology-in-dermatology
#2
REVIEW
Kevin K John, Jakob D Jensen, Andy J King, Manusheela Pokharel, Douglas Grossman
Eye-tracking technology has been used within a multitude of disciplines to provide data linking eye movements to visual processing of various stimuli (i.e., x-rays, situational positioning, printed information, and warnings). Despite the benefits provided by eye-tracking in allowing for the identification and quantification of visual attention, the discipline of dermatology has yet to see broad application of the technology. Notwithstanding dermatologists' heavy reliance upon visual patterns and cues to discriminate between benign and atypical nevi, literature that applies eye-tracking to the study of dermatology is sparse; and literature specific to patient-initiated behaviors, such as skin self-examination (SSE), is largely non-existent...
April 6, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29653209/diversity-in-dermatology-roadmap-for-improvement
#3
Ellen N Pritchett, Amit G Pandya, Nkanyezi N Ferguson, Shasa Hu, Alex G Ortega-Loayza, Henry W Lim
The American Academy of Dermatology (AAD) has taken an active stance in addressing the lack of racial and ethnic diversity in the specialty. At the AAD President's Conference on Diversity in Dermatology held August 5, 2017, key action items were identified in three main areas in order to increase the number of practicing, board-certified dermatologists who are underrepresented in medicine (UIM). These include: increasing the pipeline of UIM students applying to medical school; increasing the exposure and level of interest of UIM medical students in dermatology; and increasing the number of UIM students recruited into dermatology residency programs...
April 10, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29653208/efficacy-and-safety-of-ixekizumab-over-4-years-of-open-label-treatment-in-a-phase-2-study-in-chronic-plaque-psoriasis
#4
Claus Zachariae, Kenneth Gordon, Alexandra Kimball, Mark Lebwohl, Andrew Blauvelt, Craig Leonardi, Daniel Braun, Missy McKean-Matthews, Russel Burge, Gregory Cameron
BACKGROUND: Ixekizumab has demonstrated improvement in moderate-to-severe psoriasis patients by selectively targeting interleukin-17A, a pro-inflammatory cytokine important in psoriasis pathogenesis. OBJECTIVE: To report 4-year efficacy and safety results from the open-label extension (OLE) of this phase 2 trial. METHODS: Analysis was by last observation carried forward. Patients received ixekizumab 120 mg then 80 mg subcutaneously once every 4 weeks...
April 10, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29651917/erythematous-skin-lesions-with-necrotic-centers-on-lower-extremities-due-to-the-use-of-ruxolitinib-for-primary-myelofibrosis
#5
Constantin A Dasanu
Ruxolitinib is a small molecule JAK-2 inhibitor approved for the treatment of certain myeloproliferative neoplasms. Ruxolitinib-related skin toxicity is extremely rare. We report herein an unusual erythematous skin eruption with necrotic centers involving lower extremities in a patient with primary myelofibrosis treated with ruxolitinib. Awareness of this unusual skin toxicity with ruxolitinib becomes even more important as JAK-2 inhibition might soon find clinical applications in dermatology.
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29651516/-skin-cancer-screening-and-treatment-costs-utilisation-of-the-skin-cancer-screening-and-skin-cancer-treatment-costs-in-organ-transplant-recipients
#6
D Jäckel, N I Schlothauer, H Zeeb, G Wagner, M M Sachse
BACKGROUND: Organ transplant recipients have an up to 250-times higher risk to develop skin cancer. This article evaluated the utilisation of skin cancer screening and the treatment costs for skin cancer in organ transplant recipients. Patients of the health insurance AOK Bremen/Bremerhaven had been identified and the need for skin cancer prevention trainings was derived. METHODS: The number of organ transplant recipients (ICD code Z94.0-4) with and without any history of skin cancer (ICD code C43/C44), the utilisation of dermatologic health care services, and the costs for treatments with the diagnosis Z94...
April 12, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29650685/osimertinib-a-novel-dermatologic-adverse-event-profile-in-patients-with-lung-cancer
#7
Chia-Yu Chu, Jennifer Choi, Beth Eaby-Sandy, Corey J Langer, Mario E Lacouture
Dermatologic adverse events (dAEs) are common with the use of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy. First- and second-generation agents (erlotinib, gefitinib, and afatinib) are frequently associated with acneiform rash, pruritus, xerosis, and paronychia; the incidence and characterization of these dAEs have been well described. However, there is evidence that the dAE profile is different with third-generation EGFR-TKIs. Herein, we describe the dAEs associated with third-generation EGFR-TKIs and our clinical experience with osimertinib, a third-generation EGFR-TKI approved by the U...
April 12, 2018: Oncologist
https://www.readbyqxmd.com/read/29650464/clioquinol-an-alternative-antimicrobial-agent-against-common-pathogenic-microbe
#8
Z You, X Ran, Y Dai, Y Ran
Skin and soft tissue infections (SSTIs) are very common in dermatology and the use of antimicrobial formulations are important in treating these diseases. With the increasing of drug-resistant strains, researchers need to find ways to enhance the effectiveness and/or reduce the drug resistance. Clioquinol was one of antiseptics that can inactivate microbes. It was lack of data of antimicrobial activity; meanwhile it was infrequently used in infection. In order to research the antimicrobial spectrum and activity of topical 3% clioquinol cream among common pathogenic microorganisms compared with other common topical pharmaceuticals, we used modified agar diffusion assay to judge drug susceptibility and compared with broth microdilution assay...
April 10, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29649923/diffuse-dermatophytosis-occurring-on-dimethyl-fumarate-therapy
#9
Jeffrey I Greenstein
BACKGROUND: Opportunistic infections have occurred during dimethyl fumarate (DMF) therapy. OBJECTIVE: Diffuse skin dermatophytosis which occurred during DMF therapy in the setting of lymphopenia is described. METHODS AND RESULTS: The clinical course, the lymphocyte subset profile, and dermatologic evaluations were reviewed. In both instances, there was no other cause of lymphopenia or immune suppression, and it is likely that the tinea infections are associated with DMF therapy...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29648989/analysis-of-sexual-problems-in-men-with-psoriasis
#10
Marta Wojciechowska-Zdrojowy, Adam Reich, Jacek C Szepietowski, Adam Wojciechowski
INTRODUCTION: Psoriasis may have negative impact on many aspects of patient life. OBJECTIVE: The aim of the study was to evaluate the influence of psoriasis on erectile dysfunction and other sexual problems in men with psoriasis. MATERIALS AND METHODS: A total of 76 men aged between 20 and 66 years (mean 43.9±13.2 years) were enrolled. Psoriasis severity assessed according to PASI ranged from 2.0 to 49.8 points (mean 15.1±10.3 points). All patients were asked to complete International Index of Erectile Function (IIEF-5), Beck's Depression Inventory and Dermatology Life Quality Index...
April 12, 2018: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/29648825/rational-drug-design-of-topically-administered-caspase-1-inhibitors-for-the-treatment-of-inflammatory-acne
#11
Jean-Francois Fournier, Laurence Clary, Sandrine Chambon, Laurence Dumais, Craig Steven Harris, Corinne Millois-Barbuis, Romain Pierre, Sandrine Talano, Etienne Thoreau, Jérome Aubert, Michèle Aurelly, Claire Bouix-Peter, Anne Brethon, Laurent Chantalat, Olivier Christin, Catherine Comino, Ghizlane El-Bazbouz, Anne-Laurence Ghilini, Tatiana Isabet, Claude Lardy, Anne-Pascale Luzy, Céline Mathieu, Kenny Mebrouk, Danielle Orfila, Jonathan Pascau, Kevin Reverse, Didier Roche, Vincent Rodeschini, Laurent François Hennequin
The use of an interleukin beta antibody is currently being investigated in the clinic for the treatment of acne, a dermatological disorder affecting 650M persons globally. Inhibiting the protease responsible for the cleavage of inactive pro-IL1β into active IL-1β, caspase-1, could be an alternative small molecule approach. This report describes the discovery of uracil 20, a potent (38 nM in THP1 cells assay) caspase-1 inhibitor for the topical treatment of inflammatory acne. The uracil series was designed according to published caspase-1 pharmacophore model involving a reactive warhead in P1 for covalent reversible inhibition and an aryl moiety in P4 for selectivity against the apoptotic caspases...
April 12, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29648673/structured-diagnostic-approach-and-risk-assessment-in-mucous-membrane-pemphigoid-with-oesophageal-involvement
#12
Sandrine Benoit, Michael Scheurlen, Matthias Goebeler, Johanna Stoevesandt
Oesophageal involvement in mucous membrane pemphigoid is considered rare, but it may be underdiagnosed. To assess the incidence of oesophageal involvement in a group of patients with newly diagnosed mucous membrane pemphigoid we retrospectively analysed the medical records of 30 consecutive patients with mucous membrane pemphigoid diagnosed between 2006 and 2016 at the Department of Dermatology, University Hospital Würzburg. Twenty-one patients (70%) reported symptoms indicative of oesophageal mucous membrane pemphigoid...
April 12, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29648669/a-clinical-prediction-model-for-surgical-site-infections-in-dermato-logical-surgery
#13
Xiaomeng Liu, Nicole W J Kelleners-Smeets, Melissa Sprengers, Vishal Hira, Klara Mosterd, Patty J Nelemans
To adequately identify patients at risk for surgical site infection in dermatological surgery and effectively prescribe antibiotic prophylaxis, a prediction model may be helpful. Such a model was developed using data from 1,407 patients who underwent dermatological surgery without antibiotic prophylaxis. The multivariable logistic regression model included type of closure, tumour location and defect size as risk factors. Bootstrapping was used for internal validation. The overall performance of the model was good, with an area under the curve of 84...
April 12, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29645394/cicatricial-alopecia
#14
Varvara Kanti, Joachim Röwert-Huber, Annika Vogt, Ulrike Blume-Peytavi
In the classification of the North American Hair Research Society, primary cicatricial alopecias (PCA) are divided into four groups according to their prominent inflammatory infiltrate: PCAs with lymphocytic, neutrophilic, mixed or nonspecific cell inflammation pattern. The hair loss can begin subclinically and progress slowly so that the exact onset of the disease is often difficult to determine. The diagnosis is often delayed. While most forms of cicatricial alopecia can be clearly diagnosed based on clinical presentation in the acute disease stage, diagnosis can be challenging in the subacute, early or late disease stages...
April 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29645380/s1-guidelines-dermatoses-associated-with-dermal-lymphostasis
#15
Joachim Dissemond, Finja Jockenhöfer, Anya Miller, Günter Kurzhals, Shahrouz Noori, Stefanie Reich-Schupke, Martin Schlaeger, Erich Schubert, Markus Stücker, Tobias Weberschock, Hans Wilfried Jungkunz
The objective of the present S1 guidelines is to present current knowledge about dermatologically relevant diseases associated with localized dermal lymphostasis, thus facilitating their early detection, diagnostic workup, and targeted treatment. Whenever possible, treatment should be based on stage-appropriate and clearly defined algorithms. The numerous issues regarding differential diagnosis and treatment clinicians are confronted with in everyday clinical practice seem to warrant the publication of up-to-date guidelines...
April 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29645372/3-rd-science-days-of-the-austrian-society-of-dermatology-and-venereology-%C3%A3-gdv-forschungstage
#16
Christine M Prodinger, Georg Stary, Verena Paulitschke, Wolfram Hoetzenecker, Verena Moosbrugger-Martinz, Lisa Arzt, Matthias Schmuth
No abstract text is available yet for this article.
April 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29642579/dual-effects-of-alpha-hydroxy-acids-on-the-skin
#17
REVIEW
Sheau-Chung Tang, Jen-Hung Yang
AHAs are organic acids with one hydroxyl group attached to the alpha position of the acid. AHAs including glycolic acid, lactic acid, malic acid, tartaric acid, and citric acid are often used extensively in cosmetic formulations. AHAs have been used as superficial peeling agents as well as to ameliorate the appearance of keratoses and acne in dermatology. However, caution should be exercised in relation to certain adverse reactions among patients using products with AHAs, including swelling, burning, and pruritus...
April 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29630165/distance-to-pharmacy-and-risk-of-medication-primary-nonadherence
#18
Joseph A Moo-Young, Elizabeth A Suarez, Adewole S Adamson
Primary nonadherence, a form of prescription nonadherence, is defined as failure to fill and pick up a prescription medication. Little is known about the relationship between distance to pharmacy and primary nonadherence in dermatology. In this study, we investigated the association between primary nonadherence and distance between a patient's home and pharmacy. We focused on a low-income patient population within the dermatology clinic of a large, urban county hospital system in which patients were enrolled in a pharmacy benefit within a closed-system...
February 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29630162/fluctuating-lesion-of-the-scalp-after-a-journey-to-the-tropics-a-case-of-furunculoid-myiasis
#19
Sara Geyer, Galina Balakirski, Dennis Tappe, Claudio Cacch, Ruth Knüchel-Clarke, Laurenz Schmit
Fluctuating lesions or furuncles of the scalp occur frequently in dermatological practice. This clinical condition is often caused by gram positive bacteria (e.g. staphylococcal or streptococcal skin infection) or fungal infection (e.g. Kerion celsi). However, a rare diagnosis such as myiasis might be considered, especially if a journey to an endemic area is reported. Herein, we present a case of furunculoid myiasis of the scalp and review the pathogenesis and therapeutic options to treat this condition.
February 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29630159/growth-of-mobile-applications-in-dermatology-2017-update
#20
Hania K Flaten, Chelsea St Claire, Emma Schlager, Cory A Dunnick, Robert P Dellavalle
BACKGROUND: More than 80% of households in the US have a smartphone. Growth of mobile applications (apps) has grown in parallel with access to smartphones. Mobile health apps are used in medical fields, including dermatology. These apps allow patients to access information regarding dermatology conditions as well as access physicians via teledermatology. PURPOSE: To analyze changes in number of dermatology mobile apps since 2014 and discuss benefits and drawbacks of mobile application growth to dermatology...
February 15, 2018: Dermatology Online Journal
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