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https://www.readbyqxmd.com/read/28724114/oral-macrolides-for-the-dermatologic-manifestations-of-blau-syndrome
#1
Shalini Thareja, Kaitlyn Kollmann, Kaveh Ardalan, Marisa S Klein-Gitelman, Amy S Paller, Lisa M Arkin
No abstract text is available yet for this article.
July 19, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28722378/-a-new-vision-of-skin
#2
Adèle Rakosi, Francois Kuonen, Olivier Gaide
As of today, the skin will never look the same. Indeed, several technologies allowing the observation of the skin at a microscopic level are now coming of age. This magnifies our visual acuity and thus our capacity to recognize various pathological processes. We herein present three different methods of non-invasive skin imaging we have worked with at the CHUV, which revolutionize the practice of dermatology. In vivo confocal microscopy, ex-vivo confocal microscopy and optical coherence tomography are complementary techniques that are now becoming essential for the modern management of skin cancers, among other uses...
March 29, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28721966/use-of-skin-lightening-products-among-outpatient-attendees-in-a-north-indian-hospital
#3
Celestine Wong, Samuel Wong, Howard Tang, Rashi Minocha, Rajesh Singh, Nathan Grills
In India, fair skin is a highly valued physical attribute. Skin lightener products comprise 60% of the dermatological market. This cross-sectional study was conducted in the general medical outpatient clinics of Champa Christian Hospital to elucidate the perceptions of fair skin and determinants/pattern of skin lighter use. Demographics, pattern of skin lightener use and incidence of side effects, perceptions of lighter skin tones were the main outcomes and measures studied. The use of skin lighteners was highly prevalent in our study population...
April 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28721095/chemotherapy-associated-paronychia-treated-with-2-povidone-iodine-a-series-of-cases
#4
Kara Capriotti, Joseph Capriotti, Jesse Pelletier, Kevin Stewart
BACKGROUND: Nail changes are known to occur during the use of chemotherapy for a variety of malignancies, particularly those treated with taxanes and EGFR inhibitors. There are currently no actively recruiting prospective clinical trials investigating potential treatments. There are also no US Food and Drug Administration-approved medical treatments for chemotherapy-associated paronychia and no consensus on the best way to treat these common chemotherapy-induced events. METHODS: A retrospective review of all cases presenting to a single dermatology private practice from June 2016 to January 2017 identified nine patients with chemotherapy-associated paronychia seeking treatment...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28717410/fish-scale-collagen-peptides-protect-against-cocl2-tnf-%C3%AE-induced-cytotoxicity-and-inflammation-via-inhibition-of-ros-mapk-and-nf-%C3%AE%C2%BAb-pathways-in-hacat-cells
#5
Fazli Subhan, Hae Yeong Kang, Yeseon Lim, Muhammad Ikram, Sun-Yong Baek, Songwan Jin, Young Hun Jeong, Jong Young Kwak, Sik Yoon
Skin diseases associated with inflammation or oxidative stress represent the most common problem in dermatology. The present study demonstrates that fish scale collagen peptides (FSCP) protect against CoCl2-induced cytotoxicity and TNF-α-induced inflammatory responses in human HaCaT keratinocyte cells. Our study is the first to report that FSCP increase cell viability and ameliorate oxidative injury in HaCaT cells through mechanisms mediated by the downregulation of key proinflammatory cytokines, namely, TNF-α, IL-1β, IL-8, and iNOS...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28715582/iris-freckles-a-potential-biomarker-for-chronic-sun-damage
#6
Christoph Schwab, Christoph Mayer, Iris Zalaudek, Regina Riedl, Markus Richtig, Werner Wackernagel, Rainer Hofmann-Wellenhof, Georg Richtig, Gerald Langmann, Lisa Tarmann, Andreas Wedrich, Erika Richtig
Purpose: To investigate the role of sunlight exposure in iris freckles formation. Methods: We prospectively examined volunteers attending a skin cancer screening program conducted by ophthalmologists and dermatologists. Frequency and topographical variability of iris freckles were noted and associated with behavioral and dermatologic characteristics indicating high sun exposure. Results: Six hundred thirty-two participants (n = 360; 57% female) were examined...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28715461/tlr1-10-nf-%C3%AE%C2%BAb-and-p53-expression-is-increased-in-oral-lichenoid-disease
#7
Peter Rusanen, Emilia Marttila, Johanna Uittamo, Jaana Hagström, Tuula Salo, Riina Rautemaa-Richardson
Toll-like receptors (TLRs) and nuclear factor-κB (NF-κB) in keratinocytes play an important role in dermatological autoimmune diseases. Tumour suppressor protein p53 regulates TLR expression. The aim of this study was to compare the expression of TLR1-TLR10, p53 and NF-κB in patients with oral lichenoid disease (OLD) with healthy mucosa. Oral mucosal biopsies from 24 patients with OLD and 26 healthy controls (HC) were analysed for the expression of TLR1-TLR10, NF-κB and p53 by immunohistochemistry. The expression of all TLRs was increased in OLD epithelia compared to HC samples and the difference was significant in TLR1, TLR3, TLR4, TLR5, TLR6 and TLR7...
2017: PloS One
https://www.readbyqxmd.com/read/28714180/tofacitinib-for-the-treatment-of-moderate-to-severe-chronic-plaque-psoriasis-in-japanese-patients-subgroup-analyses-from-a-randomized-placebo-controlled-phase-3-trial
#8
Masatoshi Abe, Chikako Nishigori, Hideshi Torii, Hironobu Ihn, Kei Ito, Makoto Nagaoka, Naoki Isogawa, Isao Kawaguchi, Yukiko Tomochika, Mihoko Kobayashi, Anna M Tallman, Kim A Papp
Tofacitinib is an oral Janus kinase inhibitor. These post-hoc analyses assessed tofacitinib efficacy and safety in Japanese patients with psoriasis enrolled in a 52-week global phase 3 study. Patients received tofacitinib 5 mg, tofacitinib 10 mg or placebo twice daily (b.i.d.); placebo-treated patients advanced to tofacitinib at week 16. Primary efficacy end-points were the proportions of patients with 75% or more reduction from baseline Psoriasis Area and Severity Index (PASI-75) and Physician's Global Assessment (PGA) of "clear" or "almost clear" (PGA response) at week 16...
July 17, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28713100/-dermatological-and-rheumatic-symptoms-in-neoplasmas
#9
Magdalena Krajewska-Włodarczyk, Agnieszka Owczarczyk-Saczonek, Waldemar Placek
Some of the symptoms that occur in neoplasmas are not directly related to tumor mass or metastasis. These may be an expression of paraneopastic syndromes and occur simultaneously or during neoplastic disease, but it is extremely important that they can precede the first symptoms of malignancy by several months or years. The clinical picture of paraneopastic syndromes often includes symptoms of defined disease or symptoms which resemble them. The association of neoplasmas and certain dermatological or rheumatic diseases is complex...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28712272/quality-of-life-among-dermatology-patients-a-systematic-review-of-investigations-using-qualitative-methods
#10
Sanminder Singh, Nazanin Ehsani-Chimeh, Heather Kornmehl, April W Armstrong
INTRODUCTION: Quality of life may be assessed using quantitative or qualitative methods. Quantitative methods are commonly used in research settings; however, they may fail to capture the full range of patient experiences and impact on quality of life. Qualitative methods may be used to address this limitation. In this systematic review, we aim to synthesize data from articles utilizing qualitative methods to assess quality of life in dermatology patients. EVIDENCE ACQUISITION: We performed a systematic review search using the MEDLINE, EMBASE, and SCOPUS databases...
July 13, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28711840/a-promising-protected-ascorbic-acid-hydroxyapatite-nanocomposite-as-a-skin-anti-ager-a-detailed-photo-and-thermal-stability-study
#11
Mahmoud A Sliem, Rania A Karas, M A Harith
A new ascorbic acid (AA) nanocomposite with low toxicity and high photo and thermal stability is constructed for certain dermatological applications in humans. The presented nanocomposite consists of AA, nano-hydroxyapatite (nHAp) and carboxymethyl cellulose (CMC). The physicochemical properties of such CMC-nHAp-AA nanocomposite were characterized using X-Ray diffractometery (XRD), Fourier Transform Infra-Red (FTIR), Energy Dispersive X-ray (EDX) and UV-VIS spectroscopies. The size and morphology of the synthesized nanocomposites were characterized by TEM/SEM techniques...
July 8, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28711639/skin-permeability-enhancement-by-bacillus-subtilis-alkaline-protease-application-to-transdermal-drug-delivery
#12
Mohamed I Nounou, Taha I Zaghloul, Nehal A Ahmed, Amira A Eid, Labiba K El-Khordagui
Enzymes may offer great potentials in topical pharmaceutical applications provided that treatment conditions are controlled for efficacy and safety. In this study, the effect of alkaline protease produced by recombinant Bacillus subtilis cells on the ex-vivo permeability of rabbit ear skin was investigated under different conditions of enzyme activity (5-60 units) and exposure time (15-60min). Data for transepidermal water loss (TEWL) and permeation of a hydrophilic dye, rhodamine B (Rb), indicated biphasic activity-dependent and exposure time-dependent skin permeability...
July 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28711095/recommendations-for-culturally-competent-dermatology-care-of-muslim-patients
#13
EDITORIAL
Aamir Hussain
No abstract text is available yet for this article.
August 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28711091/update-on-sunscreens-distributed-by-major-us-retailers-that-meet-american-academy-of-dermatology-recommendations
#14
Ariel E Eber, Frances M Walocko, John Tsatalis, Marina Perper, Jessica Cervantes, Siri Choragudi, Keyvan Nouri
No abstract text is available yet for this article.
August 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28711083/bedside-diagnostics-in-dermatology-parasitic-and-noninfectious-diseases
#15
REVIEW
Robert G Micheletti, Arturo R Dominguez, Karolyn A Wanat
In addition to aiding the diagnosis of viral, bacterial, and fungal diseases, mineral oil preparation, Tzanck smear, and other techniques can be used to diagnose parasitic infections, neonatal pustular dermatoses, blistering diseases, Stevens-Johnson syndrome, and a plethora of other benign and malignant conditions, including granulomatous diseases and tumors. In many cases, these techniques are specific, reliable, and easy to perform and interpret. In others, a certain amount of training and expertise are required...
August 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28711082/bedside-diagnostics-in-dermatology-viral-bacterial-and-fungal-infections
#16
REVIEW
Karolyn A Wanat, Arturo R Dominguez, Zachary Carter, Pedro Legua, Beatriz Bustamante, Robert G Micheletti
Viral, bacterial, and fungal infections are frequently encountered in clinical practice, resulting in numerous cutaneous manifestations. Although diagnosis of these infections has changed over time because of technological advancements, such as polymerase chain reaction, bedside diagnostic techniques still play an important role in diagnosis and management, enabling rapid and low-cost diagnosis and implementation of appropriate therapies. This 2-part article will review both common and infrequent uses of bedside diagnostic techniques that dermatologists can incorporate into daily practice...
August 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28710837/quality-of-life-anxiety-prevalence-depression-symptomatology-and-suicidal-ideation-among-acne-patients-in-lithuania
#17
L Lukaviciute, P Navickas, A Navickas, J Grigaitiene, R Ganceviciene, C C Zouboulis
BACKGROUND/OBJECTIVE: We aimed to determine the prevalence of anxiety, depression symptomatology and suicidal ideation among patients with acne and the impact of this skin condition on the quality of life in Lithuania. METHODS: The mental health of patients with acne was assessed using an adapted Hospital Anxiety and Depression Scale, the Dermatology Quality of Life Index, questions about characteristics of acne. The study was authorized by the Regional Biomedical Research Ethics Committee...
July 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28709817/evaluation-of-a-guidelines-based-approach-to-the-treatment-of-chronic-spontaneous-urticaria
#18
Jorge Sánchez, Josefina Zakzuk, Ricardo Cardona
BACKGROUND: International scientific associations have made recommendations for the management of chronic spontaneous urticaria (CSU) that have been summarized in clinical guidelines. OBJECTIVE: To evaluate the clinical impact of guideline recommendations for CSU management. METHODS: A multicenter, triple-blinded, prospective, randomized study (the Urticaria Research of Tropical Impact and Control Assessment project; ClinicalTrials.gov identifier: NCT01940393) was performed...
July 11, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28709572/the-balancing-act-of-societies-and-of-clinical-histories
#19
Mauricio Goihman-Yahr
Individuals and societies are, respectively, confederations of cells and individuals. They function well only if their constituents work in a complementary and harmonious way. This is regulated by control mechanisms. Failure or malfunction of these leads to disease or social upheaval, respectively. Medicine, including dermatology, and government act by restoring homeostasis when self-regulation is unable to do so. Long-term or even permanent survival of individuals and societies can be achieved when profound understanding of control mechanisms becomes a reality...
July 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28709563/the-history-of-atopic-dermatitis
#20
Owen N Kramer, Mark A Strom, Barry Ladizinski, Peter A Lio
Fred Wise (1881-1950) and Marion Sulzberger (1895-1983) are often credited with introducing the term atopic dermatitis to dermatology in 1933. This definition was based on atopy, a term first created by Arthur Coca (1875-1959) and Robert Cooke (1880-1960) in 1923, when they recognized an association between allergic rhinitis and asthma. Despite its recent introduction into our medical lexicon, historical precursors of atopic dermatitis date back to at least as early as 69-140 ce. In this contribution, we highlight both the prominent individuals credited with shaping the disorder into our current interpretation and the suspected historical precursors of this disease and reported treatments...
July 2017: Clinics in Dermatology
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