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https://www.readbyqxmd.com/read/29917231/itch-and-psyche-psychiatric-aspects-of-pruritus
#1
REVIEW
Mohammad Jafferany, Maryam E Davari
Itch, also referred to as pruritus, is an unpleasant cutaneous sensation provoking the desire to scratch. It is often an uncomfortable, subjective sensation responsible for decreased quality of life in a variety of psychodermatological conditions. Comorbid psychiatric conditions, including depression and anxiety, are frequently associated with itch and scratch cycle. The reciprocal and intricate relationship between the psyche and itch has been widely studied. The neurobiology of itch involves the complexity of specific mediators, itch-related neuronal pathways, and central processing of itch...
June 19, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29917213/methotrexate-in-the-treatment-of-mycosis-fungoides-a-multicenter-observational-study-in-79-patients
#2
K Olek-Hrab, J Maj, E Chmielowska, A Jankowska-Konsur, B Olszewska, B Kręcisz, P Iwankowski, M Mackiewicz-Wysocka, Z Adamski, R Nowicki, M Sokolowska-Wojdylo
OBJECTIVE: The first report concerning methotrexate (MTX) in the treatment of Mycosis fungoides (MF) was published in 1964 by Wright. The mechanism of MTX action in the treatment of primary cutaneous T-cell lymphoma (CTCL) has been not explained in detail yet (the anti-inflammatory, immunomodulating, immunosuppressive, and cytostatic actions have been under discussion). PATIENTS AND METHODS: This is a retrospective analysis of 79 MF patients in 4 dermatology clinical centers in Poland...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29916740/preserving-skin-integrity-with-chronic-device-use-in-diabetes
#3
Laurel H Messer, Cari Berget, Christie Beatson, Sarit Polsky, Gregory P Forlenza
Skin integrity and diabetes device placement are ongoing concerns for people with diabetes who utilize continuous glucose monitors (CGMs) and continuous subcutaneous insulin infusion pumps. This is especially significant for individuals with skin sensitivities, pediatric patients, and those who use devices chronically. Dermatological complications are often cited as a barrier to device use and a reason for device discontinuation. Furthermore, it is a frequent topic of discussion in diabetes follow-up visits, although little evidence-based literature exists to guide providers in managing skin integrity issues...
June 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29915975/efficacy-assessment-of-uva1-and-narrowband-uvb-for-treatment-of-scalp-psoriasis
#4
Jing Zhou, Xuemei Yi, Ying Li, Yangfeng Ding
To compare the efficacy and safety of UVA1 and narrowband UVB (NB-UVB) therapy in the treatment of scalp psoriasis. Patients with scalp psoriasis were randomly assigned to either UVA1 or NB-UVB therapy. Both treatments were performed three times weekly for 6 weeks. Clinical efficacy was evaluated by using Psoriasis Scalp Severity Index (PSSI), and patient-reported quality of life (QoL) was assessed by Dermatology Life Quality Index (DLQI). Totally 68 patients completed the study. Both UVA1 and NB-UVB phototherapy achieved a statistically significant reduction of PSSI and DLQI scores at the end of the treatment period...
June 18, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29915656/a-deadly-prescription-combination-of-methotrexate-and-trimethoprim-sulfamethoxazole
#5
Mohsin Hamid, Bilal Lashari, Irfan Ahsan, Ida Micaily, Usman Sarwar, Joseph Crocetti
Methotrexate (MTX) is a chemotherapeutic synthetic(s) phase cell cycle inhibitor, and its role has evolved as an immunological agent in autoimmune diseases like rheumatoid arthritis, psoriasis, and systemic lupus erythematosus, etc. Trimethoprim-sulfamethoxazole (TS) is one of the most widely prescribed antibiotics commonly used for urinary tract infections, exacerbations of chronic bronchitis, traveler's diarrhea, and pneumocystis pneumonia. Both MTX and TS can have significantly overlapping side effects involving dermatologic, renal, and hematological systems, and the combination of these can be deadly...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29915642/patient-preferences-and-therapeutic-satisfaction-with-topical-agents-for-rosacea-a-survey-based-study
#6
Todd Williamson, Wendy Y Cheng, Nora McCormick, Francis Vekeman
Background: Rosacea is a chronic inflammatory skin disorder that primarily affects the convexities of the central face. Depending on the severity and type of rosacea, physicians may prescribe interventions such as behavioral changes, laser and intense pulsed light, as well as various pharmacologic therapies, including topical agents. The impact of side effects associated with topical treatments for rosacea on patient preferences and treatment satisfaction is not well-documented. Objective: To assess patients' concerns, treatment satisfaction, and quality of life (QOL) associated with topical treatments for rosacea...
April 2018: American Health & Drug Benefits
https://www.readbyqxmd.com/read/29915627/anti-inflammatory-biologics-and-anti-tumoral-immune-therapies-associated-colitis-a-focused-review-of-literature
#7
REVIEW
Weixun Zhou, Yan Huang, Jinping Lai, Jun Lu, Michael Feely, Xiuli Liu
An increasing number of drugs including monoclonal antibodies and small molecules, either anti-inflammatory or immunity-enhancing, have been developed to treat human diseases and the number of medications in these classes is likely to expand in the future. The two most commonly used categories of such therapies are the anti-inflammatory group (anti- tumor necrosis factor (TNF) α, anti-interleukins/interleukin receptors, and anti-integrin bodies) and the anti-tumoral agents (immune checkpoint inhibitors, anti-CD20, and anti-endothelial growth factor)...
June 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29914897/concurrent-metastases-of-papillary-thyroid-carcinoma-to-the-scalp-and-meckel-s-cave
#8
Patrick S Phelan, Jamie L Mull, Mohamed Z Rajput, Amy C Musiek
We present the case of a 65-year-old man with severe headaches and unilateral facial weakness, seen in consultation by the dermatology service to rule out primary cutaneous melanoma after brain imaging identified an enlarging mass within the right trigeminal (Meckel's) cave. Examination revealed only a pair of erythematous papules on the scalp, for which biopsy demonstrated metastatic papillary thyroid carcinoma. Further evaluation and subsequent thyroidectomy confirmed the origin of widespread internal disease, followed by definitive excision of scalp lesions and multimodal management of systemic involvement...
June 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29912651/fixed-drug-eruption-due-to-2-3-dimercapto-1-propanesulfonic-acid-dmps-treatment-for-mercury-poisoning-a-rare-adverse-effect
#9
Fatma Erden, Erol Rauf Agis, Meside Gunduzoz, Omer Hinc Yilmaz
Background Fixed drug eruptions (FDE) are characterized by recurrent, usually solitary erythematous or dark red macular, plaque or bullous lesions, all at the same site. Among the first choices for antidotal treatment in mercury exposure, 2,3-dimercapto-1-propanesulfonic acid (DMPS) is generally a drug with a low incidence of side effects. FDE due to DMPS was not detected in our literature research and so we aimed to present this rare case. Case Report Forty-eight-year-old male patient, gunpowder and explosives factory worker, was admitted to our hospital because of mercury exposure and we started DMPS treatment...
June 18, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29912303/early-juvenile-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-study-of-25-patients
#10
Cinthya Maria Neves Varandas, José Lucas Sena da Silva, Janeusa Rita L Primo, Maria de Fátima S P de Oliveira, Otávio Moreno-Carvalho, Lourdes Farre, Achiléa L Bittencourt
Background: HTLV-1 may cause severe diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated to HTLV-1 (IDH). The clinical characteristics and progression of 25 early onset HAM/TSP associated or not to IDH were described. Methods: Following-up 37 IDH patients with neurological examinations, 54% developed HAM/TSP. To these cases were added five cases of juvenile HAM/TSP. The patients were HTLV-1+ and were submitted to dermatological and neurological examinations...
April 18, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29912088/dermatologic-manifestations-of-colchicine-intoxication
#11
Asuman Gürkan, Melahat Melek Oğuz, Esin Boduroğlu Cengiz, Saliha Şenel
Colchicine is an anti-inflammatory drug that has a narrow therapeutic index. Poisoning typically shows 3 phases with systemic symptoms. Gastrointestinal symptoms dominate in the first phase. Dermatologic manifestations usually appear, with skin eruptions in the second phase where multiorgan failure occurs and alopecia in the third phase where organ derangements resolve. Alopecia is a cardinal feature of the third phase, but there is no specifically defined eruption for toxication. Here, we report a case of colchicine intoxication in a 16-year-old girl with maculopapular/purpuric rash and alopecia...
June 14, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29911738/the-effectiveness-of-a-pharmacist-led-sun-protection-counselling-service-results-from-a-tertiary-dermatology-centre-in-singapore
#12
Shan Xian Lee, Wei Sheng Chong, Xiu Ting Lauw, Siew Kiang Tan, Hazel H Oon
No abstract text is available yet for this article.
May 2018: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29911537/diagnostic-error-rates-in-dermatology
#13
Jianni Wu, Eve J Lowenstein
No abstract text is available yet for this article.
2018: Skinmed
https://www.readbyqxmd.com/read/29911534/rituximab-treated-pemphigus-foliaceus-in-a-schizophrenic-patient-a-challenging-exercise-in-diagnosis-management-and-follow-up
#14
Nicholas A Ross, Miriam L Vega, Matthew S Keller
Dermatology was consulted in the care of a 58-year-old man with a history of paranoid schizophrenia, neuroleptic malignant syndrome, a positive purified protein derivative test, and a lack of bathing for approximately 4 years who had been admitted to the hospital because of thick, crusted lesions over an increasing portion of his body. Admitted involuntarily, he was disinterested in the history, physical examination, and diagnostic testing. Comorbid schizophrenia presented a unique challenge because he was unable to participate in his care effectively...
2018: Skinmed
https://www.readbyqxmd.com/read/29910629/investigating-the-therapeutic-potential-of-a-probiotic-in-a-clinical-population-with-chronic-hand-dermatitis
#15
Wayne P Gulliver, Andrew S Hutton, Noam Ship
Background: Hand dermatitis or hand eczema (HD) is one of the most common dermatologic conditions. Lesions, scaling, pruritus and pain are chronic and relapsing. Improved HD has been reported with the probiotic composed of Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 (Bio-K+). Purpose: Investigation of the therapeutic potential of this probiotic as the sole systemic treatment for adults with nonacute HD. Subjects and methods: A single-center study documented clinical ratings and patient-reported outcomes in adults with chronic HD...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29910568/dermatological-manifestations-of-hiv-aids-individuals-in-shiraz-south-of-iran
#16
Mohammad Ali Davarpanah, Nasrin Motazedian, Farideh Jowkar
Introduction: HIV infection remains as a major challenge facing medical sciences in the world today. Mucocutaneous manifestation was first observed in patients with HIV/AIDS in the early 1980s. The aim of this study was to identify various skin manifestations based on making careful clinical observations and performing the necessary tests. Materials and Methods: A total of 240 patients whose disease was diagnosed using WB and ELISA tests, with dermatologic manifestations and were older than 18 years, participated in this study...
April 2018: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29908818/dermatoses-caused-by-cultural-practices-therapeutic-cultural-practices
#17
REVIEW
Neelam A Vashi, Nicole Patzelt, Stephen Wirya, Mayra B C Maymone, Pedro Zancanaro, Roopal V Kundu
With globalization and widespread immigration, physicians increasingly encounter patients from varying backgrounds and diverse customs. Although certain cultural practices are widely performed, there is limited medical literature describing their dermatologic and systemic effects and complications. Population diversity and sharing of traditions make it increasingly important for dermatologists to understand the role of cultural practices and recognize physiologic and pathologic sequelae. In addition, dermatologists are often adjured to assess skin findings that may be mistaken for abuse...
July 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29908767/a-qualitative-cross-sectional-study-of-positive-and-negative-comments-of-residency-programs-across-9-medical-and-surgical-specialties
#18
Brittany O Dulmage, Lisa Akintilo, Leah J Welty, Matthew M Davis, Maria Colavincenzo, Shuai Xu
IMPORTANCE: Residency applicants often use social media to discuss the positive and negative features of prospective training programs. An examination of the content discussed by applicants could provide guidance for how medical education faculty can better engage with prospective trainees and adapt to meet the educational expectations of a new generation of digital-native physicians. OBJECTIVE: To identify unstructured social media data submitted by residency applicants and categorize positive and negative statements to determine key themes DESIGN: Qualitative analysis of a retrospective cohort SETTING: Publically available data sets PARTICIPANTS: Anonymized medical trainees applying to residency training positions in nine specialties: dermatology, general surgery, internal medicine, obstetrics/gynecology, plastic surgery, otolaryngology, physical medicine and rehabilitation, pediatrics, and radiology from 2007 to 2017...
June 14, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29908586/twelfth-world-congress-of-the-international-academy-of-cosmetic-dermatology-iacd-bangalore-india-may-4-6-2017
#19
Vesna Petronic-Rosic
No abstract text is available yet for this article.
May 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29908582/dangerous-plants-in-dermatology-legal-and-controlled
#20
Deeptej Singh, Juliya Fisher, Devorah Shagalov, Aakaash Varma, Daniel M Siegel
The plant and mushroom kingdoms have species used for intoxication, inebriation, or recreation. Some of these species are toxic. Given that many of these plants or substances are illegal and have histories of abuse, much of the research regarding therapeutic application is based on basic science, animal studies, and traditional use. This review examines Cannabis, Euphorbia, Ricinus, Podophyllum, Veratrum, mushrooms, and nightshades, along with resveratrol and cocaine as they relate to dermatology.
May 2018: Clinics in Dermatology
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