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Vitamin d3

Brendan A Andres, Benjamin R Childs, Heather A Vallier
OBJECTIVES: To determine the incidence of hypovitaminosis D and to evaluate a supplementation intervention. We hypothesized that patients would exhibit high adherence with a free sample, and levels would become sufficient. DESIGN: Prospective observational study. SETTING: Level 1 trauma center. PATIENTS: One hundred forty-four consecutive, skeletally mature patients treated for acute fractures. INTERVENTION: All were provided 600 mg calcium and 800 IU vitamin D3 capsules twice daily...
April 2018: Journal of Orthopaedic Trauma
Fatemeh Mahmoodani, Conrad O Perera, Grant Abernethy, Bruno Fedrizzi, David Greenwood, Hong Chen
In a successful fortification program, the stability of micronutrients added to the food is one of the most important factors. The added vitamin D3 is known to sometimes decline during storage of fortified milks, and oxidation through fatty acid lipoxidation could be suspected as the likely cause. Identification of vitamin D3 oxidation products (VDOPs) in natural foods is a challenge due to the low amount of their contents and their possible transformation to other compounds during analysis. The main objective of this study was to find a method to extract VDOPs in simulated whole milk powder and to identify these products using LTQ-ion trap, Q-Exactive Orbitrap and triple quadrupole mass spectrometry...
March 19, 2018: Journal of the American Society for Mass Spectrometry
Ting Zhang, Hao Zhang, Liang He, Zhihong Wang, Wenwu Dong, Wei Sun, Ping Zhang
BACKGROUND Low levels of 1-25-dihydroxyvitamin D3 [1,25(OH)2D3] in serum may be a risk factor for several tumor types. Also, high cathelicidin antimicrobial peptide (CAMP) expression is regarded to be important against tumor progression. We evaluated the potential importance of 1,25(OH)2D3 in the diagnosis and treatment of papillary thyroid cancer (PTC). MATERIAL AND METHODS The preoperative serum level of 1,25(OH)2D3 was measured using a double-antibody sandwich enzyme-linked immunosorbent assay. Vitamin D3 receptor (VDR) expression was detected by streptavidin-peroxidase immunohistochemical staining in PTC specimens...
March 19, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Anna Mazanova, Ihor Shymanskyi, Olha Lisakovska, Lala Hajiyeva, Yulia Komisarenko, Mykola Veliky
Objectives: Recent prospective studies have found the associations between type 1 diabetes (T1D) and vitamin D deficiency. We investigated the role of vitamin D in the regulation of 25OHD-1 α -hydroxylase (CYP27B1) and VDR expression in different tissues of T1D rats. Design: T1D was induced in male Wistar rats by streptozotocin (55 mg/k b.w.). After 2 weeks of T1D, the animals were treated orally with or without vitamin D3 (cholecalciferol; 100 IU/rat, 30 days)...
2018: International Journal of Endocrinology
Aisha Mansoor Ali, Abdulaziz Alobaid, Tasnim Nidal Malhis, Ahmad Fawzi Khattab
BACKGROUND: Vitamin D plays pivotal role in decidualization and implantation of the placenta. Recent researches have shown that low level of vitamin D3 "25-hydroxyvitamin D (25[OH]D)" in serum is a risk factor for pre-eclampsia. Latest evidence supports role of vitamin D3 deficiency treatment in reducing the risk of pre-eclampsia. The aim of this study is to determine the effect of antenatal supplementation of vitamin D3 on the risk of pre-eclampsia and to explore the dose effect in attaining the vitamin D3 normal level...
March 2, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Petra Ložnjak, Jette Jakobsen
Information on the retention of vitamin D in food following household cooking is scarce. So far the retention of its metabolites vitamin D3 , vitamin D2 , and 25-hydroxyvitamin D3 has shown that the type of food and the cooking method are the essential determinants, and there is no significant difference between the metabolites. We investigated the retention of vitamin D3 and vitamin D2 in sunflower oil, vitamin D3 in rainbow trout, and vitamin D2 in button mushrooms. The investigated cooking methods were boiling at different pH, steam cooking, microwave cooking, pan-frying, and oven baking...
July 15, 2018: Food Chemistry
Armin Zittermann, Jana B Ernst, Sylvana Prokop, Uwe Fuchs, Jens Dreier, Joachim Kuhn, Cornelius Knabbe, Heiner K Berthold, Ioanna Gouni-Berthold, Jan F Gummert, Jochen Börgermann, Stefan Pilz
PURPOSE: Observational studies indicate a positive association between circulating 25-hydroxyvitamin D (25OHD) and testosterone (T) concentrations. Because low 25OHD concentrations and T deficiency are considered to be a generalized phenomenon in patients with advanced heart failure (HF), we aimed to investigate whether vitamin D supplementation has beneficial effects on T indices in these patients. METHODS: In a pre-specified secondary analysis of the EVITA (effect of vitamin D on mortality in heart failure) randomized controlled trial, we analyzed in male subjects with 25OHD concentrations < 75 nmol/L the effect of a daily vitamin D3 supplement of 4000 IU for 3 years (n = 71) vs...
March 15, 2018: European Journal of Nutrition
Elizabeth W Uhl
Although vitamin D is critical to calcium/phosphorus homeostasis, bone formation and remodeling, there is evolution-based variation between species in vitamin D metabolism and susceptibility to rickets and osteomalacia. Most herbivores produce vitamin D3 in response to sunlight, but dogs and cats have generally lost the ability as carnivore diets are rich in vitamin D. Nutritional deficiencies and/or poor exposure to sunlight can induce rickets in birds, swine, cattle and sheep, but horses are less susceptible as they have evolved a calcium homeostasis that is quite different than other animals...
March 13, 2018: International Journal of Paleopathology
Bei Tan, Pan Li, Hong Lv, Hong Yang, Yue Li, Ji Li, Ou Wang, Jiaming Qian
AIMS: To assess the necessity and efficacy of vitamin D supplementation in Chinese inflammatory bowel disease (IBD) patients with vitamin D insufficiency/deficiency. METHODS: Seventy-four ulcerative colitis (UC) patients and 71 Crohn's disease (CD) patients were randomly assigned into one of 3 arms for 12 months: Arm A (vitamin D3 150000IU per 3 months plus calcium 600mg oral daily); Arm B (calcium 600mg oral daily), and Arm C (vehicle control group), all in addition to conventional IBD treatment...
March 15, 2018: Journal of Digestive Diseases
Rehan M Hussain, Ninel Z Gregori, Thomas A Ciulla, Byron L Lam
Pharmacotherapy with visual cycle modulators (VCMs) is under investigation for retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), Stargardt macular dystrophy (SMD) and nonexudative age-related macular degeneration (AMD), all blinding diseases that lack effective treatment options. Areas covered: The authors review investigational VCMs, including oral retinoids, 9-cis-retinyl-acetate (zuretinol) and 9-cis-β-carotene, which restore 11-cis-retinal levels in RP and LCA caused by LRAT and RPE65 gene mutations, and may improve visual acuity and visual fields...
March 15, 2018: Expert Opinion on Pharmacotherapy
Shinji Ouma, Midori Suenaga, Funda F Bölükbaşı Hatip, Izzettin Hatip-Al-Khatib, Yoshio Tsuboi, Yoichi Matsunaga
Objectives: To determine the relevance of Mini-Mental State Examination (MMSE), serum 25-hydroxyvitamin D (25(OH)D3), and 1,25(OH)2D3 concentrations to mild cognitive impairment (MCI) and various stages of Alzheimer's disease (AD). Materials and Methods: The study included 230 participants (>74 years) allocated to three main groups: 1-healthy subjects (HS, n  = 61), 2-patients with MCI ( n  = 61), and 3- patients with Alzheimer's disease (AD) subdivided into three stages: mild ( n  = 41), moderate ( n  = 35), and severe AD ( n  = 32)...
March 2018: Brain and Behavior
Z Merhi, E Buyuk, M J Cipolla
STUDY QUESTION: Does vitamin D attenuate the adverse effects of advanced glycation end products (AGEs) on steroidogenesis by human granulosa cells (GCs)? SUMMARY ANSWER: AGEs alter the expression of genes important in steroidogenesis while 1,25-dihydroxyvitamin D3 (vit D3) in vitro attenuates some of the actions of AGEs on steroidogenic gene expression, possibly by downregulating the expression of the pro-inflammatory cell membrane receptor for AGEs (RAGE). WHAT IS KNOWN ALREADY: Vitamin D attenuates the pro-inflammatory effects of AGEs in non-ovarian tissues...
March 12, 2018: Molecular Human Reproduction
Narendra Kotwal, Vimal Upreti, Amit Nachankar, K V S Hari Kumar
Context: The number of men afflicted with osteoporosis is unknown. Aims: This study aims to determine the prevalence of osteoporosis in men. Settings and Design: This was a prospective, observational study. Subjects and Methods: A total of 200 male attendants of patients attending endocrine outpatient department and who were >55 years were recruited for the study. All the patients with osteopenia and osteoporosis were advised lifestyle interventions, supplementation with calcium carbonate (1000-1500 mg/day) and 25-hydroxyl-Vitamin D (400-600 IU/day) and bisphosphonates if indicated...
January 2018: Indian Journal of Endocrinology and Metabolism
Hyun-Soo Kim, Mingzhen Zheng, Do-Kyung Kim, Won-Pyo Lee, Sang-Joun Yu, Byung-Ock Kim
Purpose: The purpose of this study was to evaluate the effects of 1,25-dihydroxyvitamin D3 on the proliferation, differentiation, and matrix mineralization of MC3T3-E1 osteoblast-like cells in vitro. Methods: MC3T3-E1 osteoblastic cells and 1,25-dihydroxyvitamin D3 were prepared. Cytotoxic effects and osteogenic differentiation were evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, alkaline phosphatase (ALP) activity assay, ALP staining, alizarin red S staining, and reverse transcription-polymerase chain reaction (RT-PCR) for osteogenic differentiation markers such as ALP, collagen type I (Col-I), osteocalcin (OCN), vitamin D receptor (VDR), and glyceraldehyde 3-phosphate dehydrogenase...
February 2018: Journal of Periodontal & Implant Science
Hiroshi Ihara, Sachiko Kiuchi, Takayuki Ishige, Motoi Nishimura, Kazuyuki Matsushita, Mamoru Satoh, Fumio Nomura, Mine Yamashita, Isamu Kitajima, Naoko Tsugawa, Toshio Okano, Kouichi Hirota, Masakazu Miura, Masayuki Totani, Naotaka Hashizume
BACKGROUND: To assess vitamin D nutritional status, serum total 25-hydroxyvitamin D [25(OH)D] concentration is measured. We used six automated 25(OH)D immunoassays (AIAs) available in Japan and certified by the Vitamin D Standardization Program (VDSP) at U.S. CDC to assess the concordance of assay results. METHODS: Serum total 25(OH)D concentrations in SRM 972a and 20 sera from patients were determined using three liquid chromatography-tandem mass spectrometry (LC-MS/MS) and six AIAs (pilot study), and an additional 110 sera were assessed by the six AIAs (surveillance study)...
January 1, 2018: Annals of Clinical Biochemistry
Ushma Wadia, Wayne Soon, Paola Chivers, Aesen Thambiran, David Burgner, Sarah Cherian, Aris Siafarikas
Vitamin D deficiency is highly prevalent in newly settled refugees in Western Australia (WA). If adherence to daily vitamin D therapy is problematic, depot therapy is a therapeutic alternative. The aim of this study was to compare daily versus depot treatment and factors influencing the therapeutic outcome. Newly settled refugees ( n = 151) with 25(OH)D levels less than 78 nmol/L were randomised to receive daily or depot vitamin D therapy with eight weekly interval follow up to 40 weeks. Biochemical and clinical parameters were collected at each visit...
March 13, 2018: Nutrients
Aysun Türkanoğlu Özçelik, Tuğçe Öner, Birsen Can Demirdöğen, Vedat Semai Bek, Şeref Demirkaya, Orhan Adalı
Objective Vitamin D deficiency is known as an important risk factor in pathogenesis of atherosclerosis, which contributes to stroke development. Genetic variations including single nucleotide polymorphisms (SNPs) in enzymes involved in vitamin D metabolism can affect susceptibility to the development of stroke. Therefore, the objective of this study was to investigate the association between polymorphisms of vitamin D metabolizing enzymes (rs927650 SNP in CYP24A1, and rs10741657 SNP in CYP2R1 genes,) and ischemic stroke risk in Turkish population...
March 12, 2018: Neurological Research
M Herian, M R Luck, M Grzesiak
Recently it has been shown that vitamin D(3) acting via its cognate receptor (VDR) regulates the growth, differentiation and function of female reproductive tissues including ovary. The aim of the study was to examine the effect of testosterone (T) and its antagonist 2-hydroxyflutamide (HF) on VDR protein expression and function in porcine ovarian follicles. Medium size antral follicles expressing great amount of androgen receptors and represent high steroidogenic activity were used in this research. After 6 h incubation of whole follicles with T, HF or T+HF, immunohistochemical analysis of VDR revealed its nuclear localization in granulosa and theca interna cells in control and experimental groups...
March 12, 2018: Physiological Research
Olivia I Okereke, Charles F Reynolds, David Mischoulon, Grace Chang, Nancy R Cook, Trisha Copeland, Georgina Friedenberg, Julie E Buring, JoAnn E Manson
RATIONALE: Depression is a leading cause of disease burden and disability for older adults; thus, prevention is a priority. Biologic and observational data support potential mental health benefits of vitamin D and omega-3 fatty acids; however, it is unclear whether these supplements can prevent late-life depression. DESIGN: We describe the novel methodology of a large-scale prevention study: VITAL-DEP (VITamin D and OmegA-3 TriaL-Depression Endpoint Prevention), an ancillary to the VITAL trial...
March 8, 2018: Contemporary Clinical Trials
A Skalli, E H Ait Ben Haddou, R El Jaoudi, R Razine, G A Mpandzou, H Tibar, E El Fahime, N Bouslam, A Alami, A Benomar, K Hajjout, M Yahyaoui, A Bouhouche
BACKGROUND: Growing evidence suggests that hypovitaminosis D contributes to the pathogenesis of multiple sclerosis (MS). OBJECTIVE: This study aimed to evaluate whether vitamin D levels are associated with having MS and some of its characteristics in the Moroccan population. METHODS: Using liquid chromatography-tandem mass spectrometry, the 25(OH)D3 metabolite was measured to quantify vitamin D serum levels (DSLs) in 113 patients with MS and 146 healthy controls matched for gender and age...
March 7, 2018: Revue Neurologique
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