Megat H B A Hamid, Pablo F Cespedes, Chen Jin, Ji-Li Chen, Uzi Gileadi, Elie Antoun, Zhu Liang, Fei Gao, Renuka Teague, Nikita Manoharan, David Maldonado-Perez, Nasullah Khalid-Alham, Lucia Cerundolo, Raul Ciaoca, Svenja S Hester, Adán Pinto-Fernández, Simeon D Draganov, Iolanda Vendrell, Guihai Liu, Xuan Yao, Audun Kvalvaag, Delaney C C Dominey-Foy, Charunya Nanayakkara, Nikolaos Kanellakis, Yi-Ling Chen, Craig Waugh, Sally-Ann Clark, Kevin Clark, Paul Sopp, Najib M Rahman, Clare Verrill, Benedikt M Kessler, Graham Ogg, Ricardo A Fernandes, Roman Fisher, Yanchun Peng, Michael L Dustin, Tao Dong
Cancer remains one of the leading causes of mortality worldwide, leading to increased interest in utilizing immunotherapy strategies for better cancer treatments. In the past decade, CD103+ T cells have been associated with better clinical prognosis in patients with cancer. However, the specific immune mechanisms contributing toward CD103-mediated protective immunity remain unclear. Here, we show an unexpected and transient CD61 expression, which is paired with CD103 at the synaptic microclusters of T cells...
April 1, 2024: Nature Immunology