keyword
https://read.qxmd.com/read/38460030/does-selective-digestive-decontamination-sdd-increase-antibiotic-resistance-long-term-comparison-of-two-intensive-care-units-with-and-without-sdd-of-the-same-tertiary-hospital
#21
JOURNAL ARTICLE
Alicia Rodríguez-Gascón, Yanire Lloréns-Villar, María Ángeles Solinís, Helena Barrasa, Andrés Canut-Blasco
PURPOSE: The aim of this study was to to compare the antimicrobial resistance rate and its relationship with the antibiotic consumption in two separate Intensive Care Units (ICUs) of the same hospital, one with and other without selective decontamination of the digestive tract (SDD). METHODS: We performed a retrospective study in the two ICUs of the Araba University Hospital. Trauma and neurosurgical patients are admitted to the SDD-ICU, and general digestive surgery patients go to the no SDD-ICU...
March 9, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38459885/safety-of-direct-oral-provocation-test-to-delabel-reported-mild-beta-lactam-allergy-in-infants
#22
JOURNAL ARTICLE
Francisca Cunha, Inês Cunha, Eva Gomes
BACKGROUND: Around 10% of people report a drug allergy and avoid some medications because of fear of allergic reactions. However, only after a proper diagnostic workup can some of these reactions be confirmed as allergic or nonallergic hypersensitivities. Beta-lactams (BLs) are the most common medication suspected of being involved in drug hypersensivity reactions (DHRs) in children. Recently, direct oral provocation tests (DPT) with BLs gained popularity within pediatric populations as a tool for delabeling children with suspected BL allergies...
2024: Allergologia et Immunopathologia
https://read.qxmd.com/read/38459763/what-are-the-optimal-pharmacokinetic-pharmacodynamic-targets-for-%C3%AE-lactamase-inhibitors-a-systematic-review
#23
JOURNAL ARTICLE
Getnet M Assefa, Jason A Roberts, Solomon A Mohammed, Fekade B Sime
BACKGROUND: Pharmacokinetic/pharmacodynamic (PK/PD) indices are widely used for the selection of optimum antibiotic doses. For β-lactam antibiotics, fT>MIC, best relates antibiotic exposure to efficacy and is widely used to guide the dosing of β-lactam/β-lactamase inhibitor (BLI) combinations, often without considering any PK/PD exposure requirements for BLIs. OBJECTIVES: This systematic review aimed to describe the PK/PD exposure requirements of BLIs for optimal microbiological efficacy when used in combination with β-lactam antibiotics...
March 9, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38457086/influence-of-systemic-antibiotic-therapy-on-the-development-and-progression-of-induced-apical-periodontitis-in-wistar-rats
#24
JOURNAL ARTICLE
Flávio Duarte Faria, Cristiane Cantiga-Silva, Carolina de Barros Morais Cardoso, Nathália Evelyn da Silva Machado, Pedro Henrique Chaves de Oliveira, Mariana Pagliusi Justo, Juliana Goto, Rogério de Castilho Jacinto, Gustavo Sivieri-Araújo, Luciano Tavares Angelo Cintra
The aim of this study was to investigate the influence of systemic antibiotic therapy on the development and progression of induced apical periodontitis (AP) in Wistar rats. Fifty-six rats were submitted to pulp exposure of the lower left first molar for the induction of AP. On the same day, intraperitoneal antibiotic therapy was administered once a day, for 15 days, until euthanasia. The groups were formed according to the different treatments (n = 8): C-control; GEN-treated with gentamicin (10 mg/Kg); AC-treated with amoxicillin (100 mg/Kg); MZ-treated with metronidazole (40 mg/Kg); AMP-treated with ampicillin (100 mg/Kg); AMC group-treated with amoxicillin + clavulanic acid (100 mg/kg); CLI-treated with clindamycin (60 mg/kg)...
March 8, 2024: Odontology
https://read.qxmd.com/read/38450331/characteristics-and-susceptibility-pattern-of-catheter-associated-urinary-tract-infections-cauti-bacteria-in-indonesia-a-study-in-a-national-reference-hospital-of-sumatra-region-2020-2021
#25
JOURNAL ARTICLE
Muhammad A Perdana, Dian D Wahyuni, Rina Yunita
Catheter-associated urinary tract infection (CAUTI) is defined as a urinary tract infection associated with catheter placement for more than two consecutive days. Hence, antibiotic resistance in the context of CAUTIs represents a substantial challenge. The aim of this study was to present the characteristics of patients with CAUTI and the susceptibility pattern of CAUTI bacteria in the national reference hospital of the Sumatra region of Indonesia. A cross-sectional study was conducted at H. Adam Malik General Hospital, Medan, Indonesia, from 2020 to 2021, using a total sampling...
December 2023: Narra J
https://read.qxmd.com/read/38444505/-ephedra-alte-extracts-gc-ms-profiles-and-antimicrobial-activity-against-multidrug-resistant-pathogens-mrsa
#26
JOURNAL ARTICLE
Haya Ayyal Salman, Amira Suriaty Yaakop, Fuad Al-Rimawi, Ana Masara Ahmad Makhtar, Muath Mousa, Mohammad H Semreen, Naiyf S Alharbi
The extracts of E. alte offer promising potential as renewable resources for various chemical derivative products aimed at addressing antibiotic resistance. These extracts exhibited significant activity against methicillin-resistant Staphylococcus aureus (MRSA), a strain known for its resistance to multiple antibiotics. The extracts were found to be effective against several common antibiotics, including Imipenem, Ampicillin, Penicillin G, Oxacillin, and Amoxicillin-clavulanate. GC-MS analysis revealed that the phytoconstituents of E...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38440469/a-prospective-clinical-study-of-bacteriological-profile-and-their-antibiotic-susceptibilty-profile-in-patients-with-chronic-rhinosinusitis-the-recent-scenario-in-northern-india
#27
JOURNAL ARTICLE
Nainsi Gupta, Aftab Ahmed, Rubina Galib, Adil Raza
OBJECTIVES: 1. To determine the prevailing scenario of the bacteriological profile of patients with CRS, 2. To identify their antibiotic susceptibility profile. MATERIAL AND METHODS: The study was conducted on 100 patients in the Department of ENT and Microbiology from December 2020-2022. Patients above the age of 12 years were evaluated. Those who received antibiotics in the last 12 months. and age < 12 years were excluded. Patients were subjected to a detailed history, clinical and radiological examination...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38432423/involvement-of-autologous-myeloid-dendritic-cells-in-the-evaluation-of-immediate-hypersensitivity-reactions-to-betalactams
#28
JOURNAL ARTICLE
Ruben Fernandez-Santamaria, Adriana Ariza, Gador Bogas, Maria Salas, Silvia Calvo, Cecilia Frecha, C Cristobalina Mayorga, Maria Jose Torres, Tahia Diana Fernandez
BACKGROUND: Amoxicillin (AX) and clavulanic acid (CLV) are the betalactam antibiotics (BLs) most used to treat bacterial infections, although they can trigger immediate hypersensitivity reactions (IDHRs). The maturation analysis of monocyte-derived dendritic cells (moDCs) and their capacity to induce proliferative response of lymphocytes are useful to test the sensitisation to a drug, although without optimal sensitivity. Nevertheless, this can be improved using directly isolated DCs such as myeloid DCs (mDCs)...
March 1, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38432233/effect-of-tebipenem-pivoxil-hydrobromide-on-the-normal-gut-microbiota-of-a-healthy-adult-population-in-sweden-a-randomised-controlled-trial
#29
JOURNAL ARTICLE
Tsegaye Sewunet, Mohammad Razavi, Staffan Rosenborg, Angela Camporeale, Michael Nowak, David Melnick, Leanne B Gasink, Paul B Eckburg, Ian A Critchley, Carl Erik Nord, Christian G Giske
BACKGROUND: Antimicrobials cause perturbations in the composition and diversity of the host microbiome. We aimed to compare gut microbiome perturbations caused by oral tebipenem pivoxil hydrobromide (a novel carbapenem) and by amoxicillin-clavulanic acid (an orally administered β-lactam-β-lactam inhibitor combination widely used in clinical practice). METHODS: We did a phase 1, single-centre, randomised, parallel-group, active-control trial to evaluate the effect of tebipenem pivoxil hydrobromide on the human gut microbiota...
February 29, 2024: The Lancet. Microbe
https://read.qxmd.com/read/38431322/antimicrobial-resistance-profiles-of-pseudomonas-aeruginosa-escherichia-coli-and-klebsiella-pneumoniae-strains-isolated-from-broiler-chickens
#30
JOURNAL ARTICLE
Tsepo Ramatla, Prudent Mokgokong, Kgaugelo Lekota, Oriel Thekisoe
Globally, the spread of multidrug-resistant Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae from food to humans poses a severe threat to public health. The aim of this study was to assess the co-occurrence of colistin and β-lactamase resistance genes in E. coli, K. pneumoniae, and P. aeruginosa strains isolated from faeces of abattoir broiler chickens. The E. coli, P. aeruginosa and K. pneumoniae isolates were successfully detected from faecal samples by polymerase chain reaction (PCR) at infection rates of 60...
June 2024: Food Microbiology
https://read.qxmd.com/read/38406353/prevalence-of-multidrug-resistant-and-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-from-local-and-broiler-chickens-at-cibinong-market-west-java-indonesia
#31
JOURNAL ARTICLE
Syaiful Rizal, Intan Nurhapsari, Ima Fauziah, Masrukhin Masrukhin, Yoga Dwi Jatmiko
BACKGROUND AND AIM: Antimicrobial resistance (AMR) is becoming a public health concern. Foodborne pathogens are infectious agents that can be transmitted from animals to humans through food and can become resistant due to misuse and overuse of antibiotics, especially in poultry. This study aimed to detect the prevalence of multidrug-resistant and extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolated from local and broiler chickens at the Cibinong market, West Java, Indonesia...
January 2024: Veterinary World
https://read.qxmd.com/read/38394460/antimicrobial-susceptibility-profile-of-clinically-relevant-bacteroides-phocaeicola-parabacteroides-and-prevotella-species-isolated-by-eight-laboratories-in-the-netherlands
#32
JOURNAL ARTICLE
K E Boiten, D W Notermans, R J Rentenaar, J van Prehn, L G M Bode, I Maat, W van der Zwet, A Jansz, T J H Siebers, J W A Rossen, S C de Greeff, A P A Hendrickx, E J Kuijper, A C M Veloo
OBJECTIVES: Recently, reports on antimicrobial-resistant Bacteroides and Prevotella isolates have increased in the Netherlands. This urged the need for a surveillance study on the antimicrobial susceptibility profile of Bacteroides, Phocaeicola, Parabacteroides and Prevotella isolates consecutively isolated from human clinical specimens at eight different Dutch laboratories. METHODS: Each laboratory collected 20-25 Bacteroides (including Phocaeicola and Parabacteroides) and 10-15 Prevotella isolates for 3 months...
February 23, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38394140/typhoidal-salmonella-disease-in-mukuru-informal-settlement-nairobi-kenya-carriage-diversity-and-antimicrobial-resistant-genes
#33
JOURNAL ARTICLE
Purity Kasiano, Susan Kavai, Susan Kiiru, Andrew Nyerere, Samuel Kariuki
INTRODUCTION: Multiple studies have shown that typhoid fever is endemic in developing countries characterized by poor hygiene. A unique way of Salmonella Typhi (S.Typhi) pathogenicity is establishing a persistent, usually asymptomatic carrier state in some infected individuals who excrete large numbers of bacteria in faeces. This study aimed to determine the isolation rate of S.Typhi from blood and stool samples among cases and asymptomatic individuals in the Mukuru informal settlement and identify antibiotic resistance patterns within the same population...
2024: PloS One
https://read.qxmd.com/read/38392909/comparison-of-the-antibiotic-resistance-of-escherichia-coli-populations-from-water-and-biofilm-in-river-environments
#34
JOURNAL ARTICLE
Aline Skof, Michael Koller, Rita Baumert, Jürgen Hautz, Fritz Treiber, Clemens Kittinger, Gernot Zarfel
Antibiotic-resistant, facultative pathogenic bacteria are commonly found in surface water; however, the factors influencing the spread and stabilization of antibiotic resistance in this habitat, particularly the role of biofilms, are not fully understood. The extent to which bacterial populations in biofilms or sediments exacerbate the problem for specific antibiotic classes or more broadly remains unanswered. In this study, we investigated the differences between the bacterial populations found in the surface water and sediment/biofilm of the Mur River and the Drava River in Austria...
February 13, 2024: Pathogens
https://read.qxmd.com/read/38391575/antibiotic-prescribing-habits-in-dentistry-a-questionnaire-based-study
#35
JOURNAL ARTICLE
Luca Sbricoli, Giulio Grisolia, Edoardo Stellini, Christian Bacci, Marco Annunziata, Eriberto Bressan
UNLABELLED: The problem of antibiotic resistance is becoming increasingly serious worldwide due to uncontrolled prescription. Dentists are among the groups that prescribe the most antibiotics, often to delay urgent treatment. The purpose of the present study is to investigate the prescribing protocols adopted by dentists for prophylaxis and antibiotic therapy in major clinical surgical indications. METHODS: A ten-question survey was administered to a group of Italian dentists...
February 16, 2024: Antibiotics
https://read.qxmd.com/read/38390622/carbapenem-producing-enterobacteriaceae-in-mothers-and-newborns-in-southeast-gabon-2022
#36
JOURNAL ARTICLE
Sandra Dos Santos, Mesmin Moussounda, Moussa Togola, Evelyne Avoune Nguema, Christiane Matteya, Michelle Bignoumba, Richard Onanga, Jean-Bernard Lekana-Douki, Patrice François, Nathalie van der Mee-Marquet
INTRODUCTION: Infections caused by carbapenemase-producing Enterobacteriaceae (CPE) pose a significant threat, leading to severe morbidity and mortality among newborns. METHODS: This study, conducted at Franceville hospital's maternity and neonatology wards from February 22nd to June 20th, 2022, investigated the prevalence of CPE in 197 parturients and 203 newborns. Rectal swabs were taken from parturients before delivery and from newborns 30 minutes after birth...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38389968/-in-silico-analysis-of-luteolin-derivatives-as-antibacterial-agents-targeting-dna-gyrase-and-ctx-m-15-extended-spectrum-%C3%AE-lactamase-of-escherichia-coli
#37
JOURNAL ARTICLE
Nuzul Wahyuning Diyah, Dwi Ayu Indriani, Rachma Dessidianti, Siswandono Siswandono
Luteolin exhibited antibacterial activity against Escherichia coli and its chemical structure similar to that of ciprofloxacin (CPF) which works by inhibiting DNA gyrase. Filtrate from passion fruit extract containing luteolin and its derivatives could inhibit extended-spectrum β-lactamase (ESBL)-producing E . coli . Antibacterial compounds that can also inhibit ESBL will be valuable compounds to overcome the problem of resistant bacteria. This study aimed to ensure the potency of luteolin and luteolin derivatives targeting DNA gyrase and ESBL by in silico approach...
2024: Journal of Advanced Pharmaceutical Technology & Research
https://read.qxmd.com/read/38385882/hound-a-novel-tool-for-automated-mapping-of-genotype-to-phenotype-in-bacterial-genomes-assembled-de-novo
#38
JOURNAL ARTICLE
Carlos Reding, Naphat Satapoomin, Matthew B Avison
Increasing evidence suggests that microbial species have a strong within species genetic heterogeneity. This can be problematic for the analysis of prokaryote genomes, which commonly relies on a reference genome to guide the assembly process. Differences between reference and sample genomes will therefore introduce errors in final assembly, jeopardizing the detection from structural variations to point mutations-critical for genomic surveillance of antibiotic resistance. Here we present Hound, a pipeline that integrates publicly available tools to assemble prokaryote genomes de novo, detect user-given genes by similarity to report mutations found in the coding sequence, promoter, as well as relative gene copy number within the assembly...
January 22, 2024: Briefings in Bioinformatics
https://read.qxmd.com/read/38384600/an-infected-dog-bite-with-neisseria-canis-a-case-report-and-review-of-the-literature
#39
Richard Giovane, Luis Pernia, Traci Guy, Hannah Blevins
Neisseria is a common bacteria that colonizes in humans. Of the 11 species, only two, N. meningitidis and N. gonorrhea, are pathogenic. Although sparse, there are case reports of other Neisseria species causing infections in humans. Neisseria canis , which is a part of normal flora in the mouths of dogs and cats, has been shown to have potential to be pathogenic in humans. The standard treatment for dog and cat bites is oral amoxicillin/clavulanic acid (Augmentin) or IV ampicillin/sulbactam (Unasyn). However, in cases where the patient has multiple antibiotic allergies, careful antibiotic selection must be made to ensure resolution of infection...
January 2024: Curēus
https://read.qxmd.com/read/38384586/phenotypic-and-genotypic-characterization-of-extended-spectrum-beta-lactamase-producing-clinical-isolates-of-escherichia-coli-and-klebsiella-pneumoniae-in-two-kenyan-facilities-a-national-referral-and-a-level-five-hospital
#40
JOURNAL ARTICLE
Sylvia M Maveke, Gabriel O Aboge, Laetitia W Kanja, Alfred O Mainga, Naftaly Gachau, Beatrice W Muchira, Gervason A Moriasi
BACKGROUND: The emergence of antimicrobial resistance (AMR) and multidrug resistance (MDR) among Escherichia coli and Klebsiella pneumoniae , especially through the production of extended spectrum β -lactamases (ESBLs), limits therapeutic options and poses a significant public health threat. OBJECTIVE: The aim of this study was to assess the phenotypic and genetic determinants of antimicrobial resistance of ESBL-producing Escherichia coli and Klebsiella pneumoniae isolates from patient samples in two Kenyan Hospitals...
2024: International Journal of Microbiology
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