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Anal canal cancer

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https://www.readbyqxmd.com/read/29447025/anal-sphincter-dysfunction-in-patients-treated-with-primary-radiotherapy-for-anal-cancer-a-study-with-the-functional-lumen-imaging-probe
#1
Susanne Haas, Pia Faaborg, Donghua Liao, Søren Laurberg, Hans Gregersen, Lilly Lundby, Peter Christensen, Klaus Krogh
BACKGROUND: Sphincter-sparing radiotherapy or chemoradiation are standard treatments for patients with anal cancer. The ultimate treatment goal is full recovery from anal cancer with preserved anorectal function. Unfortunately, long-term survivors often suffer from severe anorectal symptoms. The aim of the present study was to characterize changes in anorectal physiology after radiotherapy for anal cancer. METHOD: We included 13 patients (10 women, age 63.4 ± 1...
February 15, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29441419/modern-intensity-modulated-radiotherapy-with-image-guidance-allows-low-toxicity-rates-and-good-local-control-in-chemoradiotherapy-for-anal-cancer-patients
#2
Berardino De Bari, Laëtitia Lestrade, Alessandra Franzetti-Pellanda, Raphael Jumeau, Maira Biggiogero, Melpomeni Kountouri, Oscar Matzinger, Raymond Miralbell, Jean Bourhis, Mahmut Ozsahin, Thomas Zilli
PURPOSE: To report outcomes of a population of anal cancer patients treated with modern intensity-modulated radiotherapy and daily image-guided radiotherapy techniques. METHODS: We analyzed data of 155 patients consecutively treated with intensity-modulated radiotherapy +/- chemotherapy in three radiotherapy departments. One hundred twenty-two patients presented a stage II-IIIA disease. Chemotherapy was administered in 138 patients, mainly using mitomycin C and 5-fluorouracil (n = 81)...
February 13, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29394850/-multidisciplinary-treatment-for-squamous-cell-carcinoma-of-the-anal-canal
#3
Hideaki Karasawa, Shinobu Ohnuma, Kazuhiro Watanabe, Takahiro Tsuchiya, Hirofumi Imoto, Takeshi Aoki, Katsuyoshi Kudoh, Naoki Tanaka, Munenori Nagao, Tomoya Abe, Hiroaki Musha, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno
Chemoradiotherapy(CRT)has been recognized as a standard treatment for locoregional squamous cell carcinoma of the anal canal in Western countries. However, surgery had historically been considered as a standard treatment and there are only a few reports on CRT for anal canal cancer in Japan. In this study, we analyzed medical records of 5 anal canal cancer patients treated with CRT in our hospital between 2005 and 2015. Patients' characteristics were as follows: median age, 70 years (range 42-80 years); male/female, 1/4; and clinical Stage I / III a/ III b, 3/1/1...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394843/-a-case-of-anal-canal-cancer-with-skin-invasion-to-which-abdominoperineal-resection-and-perineum-reconstruction-were-performed-after-neoadjuvant-chemoradiotherapy
#4
Ayumi Yamaguchi, Masakazu Miyake, Sumiko Yoshitatsu, Mamoru Uemura, Masataka Ikeda, Takeshi Kato, Takuya Hamakawa, Sakae Maeda, Naoki Hama, Kazuhiro Nishikawa, Atsushi Miyamoto, Michihiko Miyazaki, Motohiro Hirao, Shoji Nakamori, Mitsugu Sekimoto
A 74-year-old man visited our hospital with an awareness of anal mass and bleeding. He was diagnosed as adenocarcino- ma of anal canal with wide spreading skin invasion. After neoadjuvant chemoradiotherapy(radiationtotal 45 Gy/25 Fr; cape- citabine 825mg/m2)was performed to reduce the mass volume, laparoscopic abdominoperineal resection with large perineum skin resection and lateral lymph node dissection was carried out. The perineal defect was repaired with a rectus abdominis musculocutaneous flap. Six days after surgery, the rectus abdominis musculocutaneous flap necrotized, and second perineum reconstruction by the bilateral gracilis musculocutaneous flaps was performed after debridement of necrotic tissue...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394724/-a-case-report-of-anal-canal-squamous-cell-carcinoma-with-poor-prognosis-that-occurred-nine-years-after-subtotal-colectomy-for-ulcerative-colitis
#5
Toshihiro Tajirika, Nobuhisa Matsuhashi, Takao Takahashi, Kazuhiro Yoshida
Ulcerative colitis(UC)is a chronic inflammatorydisease. Since it is known to be a risk factor for colorectal cancer, severe cases, refractorycases, or cases with cancer are often treated with surgery. We report a case of anal canal squamous cell carcinoma(SCC)found 9 years after subtotal colectomy for UC. A 32-year-old man underwent subtotal colectomyand ileorectum anastomosis 9 years ago for fulminant UC. Anemia was detected during treatment with infliximab, which was initiated 2 years ago. Endoscopic findings revealed a type 3 tumor at the anal canal in the anastomotic region, and he presented to our department...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394635/-abdominoperineal-resection-for-anal-metastasis-of-rectal-cancer
#6
Keishi Hakoda, Masanori Yoshimitsu, Manabu Emi, Yuya Hirai, Atsushi Kamigaichi, Manato Osawa, Norimasa Kuraoka, Toshiaki Komo, Norifumi Tsubokawa, Ichiko Yamakita, Masashi Miguchi, Yoshiro Aoki, Akira Nakashima, Mikihiro Kano, Koichi Oishi, Toshihiko Kohashi, Mayumi Kaneko, Mahito Funakoshi, Jun Hihara, Hidenori Mukaida, Naoki Hirabayashi
Anal metastasis of colorectal cancer is rare, and no standardized effective therapeutic strategy exists. We report a case of abdominoperineal resection for anal metastasis of rectal cancer. A 65-year-old man underwent laparoscopic low anterior resection for rectal cancer in August 2013. Histopathological examination revealed a moderately differentiated adenocarcinoma( tub2, pSS, ly3, v2, pN1, H0, P0, M0, Stage III a, Cur A). In February 2015, he complained of anal discomfort, and tumor markers were elevated...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394624/-a-case-report-of-adenocarcinoma-with-pagetoid-growth-secondary-paget-s-disease-of-the-anal-canal
#7
Wataru Okajima, Yoshiaki Kuriu, Tomohiro Arita, Yasutoshi Murayama, Masayoshi Nakanishi, Tokunari Okayama, Toshiyuki Kosuga, Hirotaka Konishi, Ryo Morimura, Atsushi Shiozaki, Hisashi Ikoma, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
Differentiating primary Paget's disease from secondary Paget's disease, which is also known as Pagetoid growth of other cancers, in the perianal region is difficult. Given that the treatment strategies of both disease are significantly different, diagnosis of such conditions should be performed with caution. We report a case of secondary Paget's disease. A 76-year-old man previously visited a hospital because of erythematous plaque around the anus. It was diagnosed as extramammary Paget's disease based on skin biopsy results; consequently, perianal skin resection was performed...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29393674/target-volume-motion-during-anal-cancer-image-guided-radiotherapy-using-cone-beam-computed-tomography
#8
Corrinne J Brooks, Laurence Bernier, Vibeke N Hansen, Diana M Tait
OBJECTIVE: Literature regarding image-guidance and interfractional motion of the anal canal (AC) during anal cancer radiotherapy is sparse. This study investigates interfractional AC motion during anal cancer radiotherapy. METHODS: Bone matched cone-beam computed tomography (CBCT) images were acquired for 20 patients receiving anal cancer radiotherapy allowing population systematic and random error calculations. 12 were selected to investigate interfractional AC motion...
February 2, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29362310/-a-case-of-anal-canal-squamous-cell-carcinoma-detected-with-anal-stenosis-eight-years-following-resection-for-rectal-adenocarcinoma
#9
Takashi Fukao, Tomoko Matsumoto, Shiho Kuriyama, Tomohiro Toji, Yutaka Hirano, Yasuyuki Ohtawa, Toshihiko Waku, Kazuhiro Washio
An 89-year-old woman underwent low anterior resection for rectal adenocarcinoma(Ra, pT3N0M0, pStage II , Cur A)in 2008. In February 2016, she underwent an outpatient examination because of a defecation disturbance. Lower gastrointestinal endoscopy was performed and the stenotic region was biopsied. However, no malignancy was detected and the stenotic site expanded. However, the patient experienced recurrence of the same symptoms, developed severe anal stenosis, and underwent another examination in December 2016...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29340993/laparoscopic-assisted-modified-intersphincter-resection-for-ultralow-rectal-cancer
#10
Haiyang Zhou, Canping Ruan, Zhiguo Wang, Zhiqian Hu
BACKGROUND: Intersphincter resection (ISR) is considered to be a superior technique offering sphincter preservation in patients with ultralow rectal cancer.1 Because high-definition laparoscopy offers wider and clearer vision into the narrow pelvic cavity and intersphincteric space, ISR has been further refined.2 However, functional outcome after ISR has not been optimal. More than half of patients receiving ISR suffer partial or even complete anal incontinence.3 We therefore propose a laparoscopic-assisted modified ISR, with the aim of improving sphincter function following ISR...
January 16, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29315288/the-promise-of-immunotherapy-in-anal-squamous-cell-carcinoma-a-novel-approach-for-an-orphan-disease
#11
Benny Johnson, Cathy Eng
An estimated 8200 men and women in the United States will receive a diagnosis of squamous cell carcinoma of the anal canal (SCCA) in 2017. Although SCCA is rare, accounting for 2.6% of gastrointestinal cancers, its incidence rate has been steadily increasing over the last few decades in the United States and around the world. More than 90% of cases of SCCA occur in the context of prior human papillomavirus (HPV) infection. To date, preventive vaccinations against HPV remain markedly underutilized. Most patients who have SCCA present with locoregional disease that is cured with chemoradiation...
December 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29299375/radiation-generates-an-abscopal-response-and-complete-resolution-of-metastatic-squamous-cell-carcinoma-of-the-anal-canal-a-case-report
#12
Moss Bruton Joe, Julian J Lum, Peter H Watson, R Petter Tonseth, John Paul McGhie, Pauline T Truong
The abscopal effect is a rare phenomenon in the setting of radiation therapy (RT) for metastatic cancer where tumor regression occurs distant from the site of treatment. A proposed mechanism of the abscopal effect is the activation of a systemic antitumor immune response by localized RT. We report the first case, to our knowledge, of the abscopal effect in squamous carcinoma of the anal canal with metastases to pelvic lymph nodes, liver and bone. After palliative RT to the pelvis with sensitizing chemotherapy, complete response was observed not only in the primary tumor but also in bone and multiple liver metastases at 4 months after treatment, an effect that remained durable at 4-year follow-up...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29224507/three-anastomotic-techniques-following-laparoscopic-rectal-cancer-resection-our-experience-in-155-patients
#13
Mahtab Zanguie, Abbas Abdollahi, Roham Salek, Ali Jangjoo, Mehdi Jabbari Nooghabi, Hosein Shabahang, Hamed Golmohammadzadeh
PURPOSE: This study aimed to assess the impact of 3 anastomotic techniques after laparoscopic rectal cancer resection. METHODS: In a cross-sectional study, the data of 155 patients who underwent surgery for rectal cancer were retrieved. An anastomosis was created between the left colon and anal canal with 3 different methods: coloanal anastomosis with protective ileostomy (group A), coloanal anastomosis without ostomy (group B), and delayed coloanal anastomosis (group C)...
December 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/29208455/high-prevalence-and-incidence-of-hpv-related-anal-cancer-precursor-lesions-in-hiv-positive-women-in-the-late-haart-era
#14
Carmen Hidalgo-Tenorio, Samantha E de Jesus, Javier Esquivias, Juan Pasquau
INTRODUCTION: Anal cancer is one of the most common non-AIDS defining malignancies, especially in men who have sex with men and women living with HIV (WLHIV). OBJECTIVES: To evaluate the prevalence and incidence of precursor lesions (high-grade squamous intraepithelial lesions [HSIL]) and anal cancer in our cohort of women and to compare them to cervical lesions; to calculate the percentage of patients that acquire and clear oncogenic genotypes (HR-HPV) in the anal canal; and to determine predictive factors for anal HPV infection...
December 2, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29134349/the-impact-of-mri-sequence-on-tumour-staging-and-gross-tumour-volume-delineation-in-squamous-cell-carcinoma-of-the-anal-canal
#15
Davide Prezzi, Ramin Mandegaran, Sofia Gourtsoyianni, Katarzyna Owczarczyk, Andrew Gaya, Robert Glynne-Jones, Vicky Goh
OBJECTIVES: To compare maximum tumour diameter (MTD) and gross tumour volume (GTV) measurements between T2-weighted (T2-w) and diffusion-weighted (DWI) MRI in squamous cell carcinoma of the anal canal (SCCA) and assess sequence impact on tumour (T) staging. Second, to evaluate interobserver agreement and reader delineation confidence. METHODS: The staging MRI scans of 45 SCCA patients (25 females) were assessed retrospectively by two independent radiologists (0 and 5 years' experience of anal cancer MRI)...
November 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29112567/a-pilot-study-of-the-prevalence-of-anal-human-papillomavirus-and-dysplasia-in-a-cohort-of-patients-with-ibd
#16
Ross D Cranston, Miguel Regueiro, Jana Hashash, Jonathan R Baker, Nicola Richardson-Harman, Laura Janocko, Ian McGowan
BACKGROUND: Defective cell-mediated immunity increases the risk of human papillomavirus-associated anal dysplasia and cancer. There is limited information on anal canal disease in patients with IBD. OBJECTIVE: The purpose of this study was to assess anal/vaginal human papillomavirus and anal dysplasia prevalence in patients with IBD. DESIGN: Patients had an anal examination before routine colonoscopy. SETTINGS: The study was conducted at a tertiary IBD referral center...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29107432/-reconstruction-of-abdo-perineal-resection-by-taylor-flap-about-68-patients
#17
D Boccara, K SerroR, J Lefevre, M Mimoun, M Chaouat
PURPOSES: Healing after abdomino-perineal resection is often difficult, especially in patients who have undergone radiation therapy. Vaginal reconstruction is also an important issue for the women who undergo this surgery. We describe and analyze here our series of perineal reconstructions with modified Taylor flaps. Between 2010 and 2016, 68 patients (52 women, 16 men) with cancer of the anal canal (53), adenocarcinoma of the lower rectum (9), or other malignant neoplasms of the perineum underwent reconstruction with a rectus abdominis myocutaneous (RAM) flap with an inferior pedicle and an oblique skin paddle...
October 26, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29089827/cancer-of-the-anal-canal-diagnosis-staging-and-follow-up-with-mri
#18
REVIEW
Carole Durot, Anthony Dohan, Mourad Boudiaf, Vincent Servois, Philippe Soyer, Christine Hoeffel
Although a rare disease, anal cancer is increasingly being diagnosed in patients with risk factors, mainly anal infection with the human papilloma virus. Magnetic resonance imaging (MRI) with external phased-array coils is recommended as the imaging modality of choice to grade anal cancers and to evaluate the response assessment after chemoradiotherapy, with a high contrast and good anatomic resolution of the anal canal. MRI provides a performant evaluation of size, extent and signal characteristics of the anal tumor before and after treatment, as well as lymph node involvement and extension to the adjacent organs...
November 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29063590/the-prevalence-and-concordance-of-human-papillomavirus-infection-in-different-anogenital-sites-among-men-and-women-in-liuzhou-china-a-population-based-study
#19
Feixue Wei, Mingqiang Li, Xin Wu, Kai Yin, Jian Lan, Wei Sheng, Meng Guo, Shoujie Huang, Ying Wang, Yanping Li, Rongcheng Li, Yingying Su, Ting Wu, Jun Zhang, Ningshao Xia
Human papillomavirus (HPV) infection is the pathogenesis of anogenital cancers and genital warts in both men and women, whereas there is a scarcity of large studies focused on HPV prevalence in different anogenital sites of both sexes in the same population. From May to July 2014, 2309 men and 2378 women aged 18-55 were enrolled from a community in Liuzhou, China. Penis/glans penis/coronary sulcus (PGC) and perianal/anal canal (PA) specimens of men, and vaginal (VA), vulvar (VU) and PA specimens of women, were collected and genotyped for HPV...
October 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29049547/management-of-stage-i-squamous-cell-carcinoma-of-the-anal-canal
#20
Christy Y Chai, Hop Tran Cao, Samir Awad, Nader N Massarweh
Importance: The incidence of squamous cell carcinoma of the anal canal (SCCAC) is increasing. Although standard management of SCCAC includes the use of concurrent chemotherapy and radiotherapy (chemoradiotherapy), data are lacking on potentially less morbid, alternative management strategies, such as local excision, among patients with node-negative T1 disease. Objectives: To examine the use of local excision among patients with T1 SCCAC and to compare overall survival relative to those who received standard treatment with chemoradiotherapy...
October 18, 2017: JAMA Surgery
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