keyword
https://read.qxmd.com/read/38531338/first-in-vivo-experiment-with-pulmvalve-endobronchial-valve-feasibility-efficiency-and-safety
#21
JOURNAL ARTICLE
Jingwei Liu, Difei Chen, Yanhui Yu, Yu Deng, Ruijin Lu, Jing Zhang, Shiyue Li
INTRODUCTION: Endoscopic Lung Volume Reduction (ELVR) with endobronchial valves has been widely recognized for treating hyperinflation in advanced COPD and emphysema patients. The main challenges include the technical complexity of upper lobe implantation and the number of endobronchial valves required. These issues might be addressed by placing larger-diameter valves in the lobar bronchus. This study evaluated the feasibility, efficiency, and safety of the new valve PulmValve (model PV-13) in porcine models...
March 26, 2024: Respiration; International Review of Thoracic Diseases
https://read.qxmd.com/read/38531335/diagnostic-yield-and-safety-of-the-19-gauge-vs-22-gauge-ebus-tbna-needle-in-subjects-with-sarcoidosis-guess
#22
JOURNAL ARTICLE
Sahajal Dhooria, Inderpaul Singh Sehgal, Kuruswamy Thurai Prasad, Valliappan Muthu, Pooja Dogra, Mandeep Saini, Nalini Gupta, Amanjit Bal, Ashutosh Nath Aggarwal, Ritesh Agarwal
BACKGROUND: Observational data suggest that the 19-gauge (G) needle for endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) offers a higher diagnostic yield in sarcoidosis than the 22-G needle. No randomized trial has compared the yield of the two needles. METHODS: We randomized consecutive subjects with suspected sarcoidosis and enlarged thoracic lymph nodes to undergo EBUS-TBNA with either the 19-G or the 22-G needle. We compared the study groups for diagnostic sensitivity (primary outcome) assessed by the yield of granulomas in subjects finally diagnosed with sarcoidosis...
March 26, 2024: Respiration; International Review of Thoracic Diseases
https://read.qxmd.com/read/38531325/predicting-exacerbations-in-%C3%AE-1-antitrypsin-deficiency-using-clinical-and-pulmonary-function-tests-portuguese-earco-registry
#23
JOURNAL ARTICLE
Nuno Faria, Joana Gomes, Catarina Guimarães, Raquel Marçôa, Beatriz Ferraz, Maria Sucena
INTRODUCTION: Exacerbations are common in individuals with alpha-1-antitrypsin deficiency (AATD) related lung disease. This study intended to identify independent predictive factors for exacerbations in AATD using the Portuguese European Alpha-1 Research Collaboration (EARCO) registry. METHODS: This study includes patients from the Portuguese EARCO registry, a prospective multicentre cohort (NCT04180319). From October 2020 to April 2023 this registry enrolled 137 patients, 14 of whom were excluded for analysis for either missing 12 months of follow-up or baseline pulmonary function...
March 26, 2024: Respiration; International Review of Thoracic Diseases
https://read.qxmd.com/read/38531027/continuous-stellate-ganglion-block-for-ventricular-arrhythmias-case-series-systematic-review-and-differences-from-thoracic-epidural-anaesthesia
#24
JOURNAL ARTICLE
Veronica Dusi, Filippo Angelini, Enrico Baldi, Antonio Toscano, Carol Gravinese, Simone Frea, Sara Compagnoni, Arianna Morena, Andrea Saglietto, Eleonora Balzani, Matteo Giunta, Andrea Costamagna, Mauro Rinaldi, Anna Chiara Trompeo, Roberto Rordorf, Matteo Anselmino, Simone Savastano, Gaetano Maria De Ferrari
BACKGROUND: Percutaneous stellate ganglion block (PSGB) through single bolus injection and thoracic epidural anaesthesia (TEA) have been proposed for the acute management of refractory ventricular arrhythmias (VAs). However, data on continuous PSGB (C-PSGB) are scant. AIMS: To report our dual-center experience with C-PSGB and to perform a systematic review on C-PSGB and TEA. METHODS: Consecutive patients receiving C-PSGB at 2 centers were enrolled...
March 26, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://read.qxmd.com/read/38530679/discussion-to-four-decades-of-progress-in-heart-lung-transplantation-271-cases-at-a-single-institution
#25
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 25, 2024: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/38530665/flow-limitation-is-associated-with-excessive-daytime-sleepiness-in-individuals-without-moderate-or-severe-obstructive-sleep-apnea
#26
JOURNAL ARTICLE
Dwayne L Mann, Eric Staykov, Thomas Georgeson, Ali Azarbarzin, Samu Kainulainen, Susan Redline, Scott A Sands, Philip I Terrill
Rationale: Moderate-Severe Obstructive Sleep Apnea (OSA, AHI>15) disturbs sleep through frequent bouts of apnea and is associated with daytime sleepiness. However, many individuals without moderate-severe OSA (i.e., AHI<15) also report sleepiness. Objective: To test the hypothesis that sleepiness in the AHI<15 group is a consequence of substantial flow limitation, in the absence of overt reductions in airflow (i.e., apnea/hypopnea). Methods: N=1886 participants from the MESA sleep cohort were analyzed for frequency of flow limitation from polysomnogram recorded nasal airflow signal...
March 26, 2024: Annals of the American Thoracic Society
https://read.qxmd.com/read/38530556/multidisciplinary-approach-for-locally-advanced-non-small-cell-lung-cancer-nsclc-2023-expert-consensus-of-the-spanish-lung-cancer-group-gecp
#27
REVIEW
Aylen Vanessa Ospina, Sergio Bolufer Nadal, José Luis Campo-Cañaveral de la Cruz, Jose Luis González Larriba, Ivan Macía Vidueira, Bartomeu Massutí Sureda, Ernest Nadal, Florentino Hernando Trancho, Antonio Álvarez Kindelán, Edel Del Barco Morillo, Reyes Bernabé Caro, Joaquim Bosch Barrera, Virginia Calvo de Juan, Joaquin Casal Rubio, Javier de Castro, Ángel Cilleruelo Ramos, Manuel Cobo Dols, Manuel Dómine Gómez, Santiago Figueroa Almánzar, Rosario Garcia Campelo, Amelia Insa Mollá, José Ramón Jarabo Sarceda, Unai Jiménez Maestre, Rafael López Castro, Margarita Majem, Alex Martinez-Marti, Elisabeth Martínez Téllez, David Sánchez Lorente, Mariano Provencio
INTRODUCTION: Recent advances in the treatment of locally advanced NSCLC have led to changes in the standard of care for this disease. For the selection of the best approach strategy for each patient, it is necessary the homogenization of diagnostic and therapeutic interventions, as well as the promotion of the evaluation of patients by a multidisciplinary oncology team. OBJECTIVE: Development of an expert consensus document with suggestions for the approach and treatment of locally advanced NSCLC leaded by Spanish Lung Cancer Group GECP...
March 26, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38530405/integrative-network-analysis-of-differentially-methylated-regions-to-study-the-impact-of-gestational-weight-gain-on-maternal-metabolism-and-fetal-neonatal-growth
#28
JOURNAL ARTICLE
Perla Pizzi Argentato, João Victor da Silva Guerra, Liania Alves Luzia, Ester Silveira Ramos, Mariana Maschietto, Patrícia Helen de Carvalho Rondó
Integrative network analysis (INA) is important for identifying gene modules or epigenetically regulated molecular pathways in diseases. This study evaluated the effect of excessive gestational weight gain (EGWG) on INA of differentially methylated regions, maternal metabolism and offspring growth. Brazilian women from "The Araraquara Cohort Study" with adequate pre-pregnancy body mass index were divided into EGWG (n=30) versus adequate gestational weight gain (AGWG, n=45) groups. The methylome analysis was performed on maternal blood using the Illumina MethylationEPIC BeadChip...
2024: Genetics and Molecular Biology
https://read.qxmd.com/read/38530061/covid-19-severity-and-mortality-in-veterans-with-chronic-lung-disease
#29
JOURNAL ARTICLE
Kristina Crothers, Scott V Adams, Aaron P Turner, Lisa Batten, Reyhaneh Nikzad, John R Kundzins, Vincent S Fan
INTRODUCTION: Chronic lung disease (CLD) has been associated with risk for more severe manifestations and death with COVID-19. However, few studies have evaluated the risk overall and by type of CLD for severity of COVID-19 outcomes in a US national cohort. METHODS: Using data from the Veterans Health Administration, we determined the risk associated with CLDs including COPD (mild/severe), asthma (mild/active/severe), idiopathic pulmonary fibrosis (IPF), sarcoidosis and other interstitial lung diseases (ILDs) for outcomes among veterans with SARS-CoV-2 positive tests between 3/1/2020-4/30/2021...
March 26, 2024: Annals of the American Thoracic Society
https://read.qxmd.com/read/38530051/vessel-and-airway-characteristics-in-one-year-ct-defined-rapid-emphysema-progression-spiromics
#30
JOURNAL ARTICLE
Sarah E Gerard, Timothy M Dougherty, Prashant Nagpal, Dakai Jin, MeiLan K Han, John D Newell, Punam K Saha, Alejandro P Comellas, Christopher B Cooper, David Couper, Spyridon Fortis, Junfeng Guo, Nadia N Hansel, Richard E Kanner, Ella A Kazeroni, Fernando J Martinez, Amin Motahari, Robert Paine Iii, Stephen Rennard, Joyce D Schroeder, Prescott G Woodruff, R Graham Barr, Benjamin M Smith, Eric A Hoffman
Rationale: Rates of emphysema progression vary in chronic obstructive pulmonary disease (COPD), and the relationship with vascular and airway pathophysiology remain unclear. Objective: We sought to determine if indices of peripheral (segmental and beyond) pulmonary arterial (PA) dilation measured via computed tomography (CT) are associated with a 1-year index of emphysema (EI: %voxels<-950HU) progression. Methods: 599 GOLD 0-3 former and never-smokers were evaluated from the SubPopulations and InterMediate Outcome Measures in COPD Study (SPIROMICS) cohort: rapid-emphysema-progressors (RP, n=188; 1-year ΔEI>1%), non-progressors (NP, n=301; 1-year ΔEI±0...
March 26, 2024: Annals of the American Thoracic Society
https://read.qxmd.com/read/38529885/botulinum-toxin-injections-for-the-treatment-of-neurogenic-thoracic-outlet-syndrome-a-systematic-review
#31
REVIEW
Tyler T Woodworth, Austin Le, Campbell Miller, Aaron Conger, Mark A Mahan, Daniel M Cushman
Botulinum toxin (BTX) injections into the musculature surrounding the brachial plexus have been examined as a potential treatment for neurogenic thoracic outlet syndrome (nTOS). This systematic review identified 15 publications, of which one was a randomized controlled trial. BTX injections performed with ultrasound or electromyographic guidance, and with the inclusion of the pectoralis minor muscle, in addition to the anterior and/or middle scalenes, tended to provide greater symptom improvement and may predict response to first rib resection...
March 26, 2024: Muscle & Nerve
https://read.qxmd.com/read/38529514/assessment-of-bronchodilator-responsiveness-to-salbutamol-or-ipratropium-using-different-criteria-in-treatment-na%C3%A3-ve-patients-with-asthma-and-copd
#32
JOURNAL ARTICLE
Zsófia Lázár, Alpár Horváth, Szilvia Kiss-Dala, Zsolt Abonyi-Tóth, Balázs Csoma, Katalin Kontz, Lilla Tamási, Veronika Müller
BACKGROUND: The criteria for significant bronchodilator responsiveness (BDR) were published in 2005 by the European Respiratory Society/American Thoracic Society, which were revised in 2021, however, data on the agreement between these two recommendations in untreated patients with airflow limitation are missing. AIMS: We aimed to study BDR to salbutamol (SABA) or ipratropium bromide (SAMA) in patients with suspected bronchial asthma or COPD at initial clinical presentation using the 2005 and 2021 criteria and explore clinical factors associated with BDR+...
2024: European Clinical Respiratory Journal
https://read.qxmd.com/read/38528947/massive-pleural-effusion-in-porous-diaphragm-syndrome-due-to-lymphatic-leakage-after-pelvic-surgery
#33
Masashi Nishimura, Takunori Ogawa, Tomomi Tanigaki, Koji Sumi, Yasuhiro Enjoji, Yohsuke Suyama, Akihiko Kawana, Yoshifumi Kimizuka
We present the case of a patient who developed a massive right pleural effusion after pelvic surgery, not thoracic surgery. Lymphatic leakage into the abdominal cavity after pelvic surgery can cause massive pleural effusion when complicated with porous diaphragm syndrome.
March 2024: Respirology Case Reports
https://read.qxmd.com/read/38528946/giant-bullous-emphysema-successfully-treated-with-percutaneous-drainage-followed-by-resection-a-case-complicated-by-lung-cancer-diagnosed-by-intraoperative-biopsy
#34
Sachie Hasegawa, Mako Yokoyama, Toshihide Inui, Hiroaki Ishikawa, Hiroko Watanabe, Masaki Kimura, Susumu Yoshida, Tohru Sakamoto
We present a case of bilateral giant bullous emphysema (GBE) with rapidly progressive dyspnea. The dyspnea was thought to be due to tension bullae caused by the check valve mechanism in COVID-19 bronchitis. Multiple nodules were also detected on both sides of the lung. As the patient had poor pulmonary reserve for surgical bullectomy, we first performed percutaneous intracavitary drainage. Prior to this procedure, we placed a chest tube in the thoracic cavity to avoid tension pneumothorax. As a result, the patient's remaining lung expanded and respiratory status improved, allowing him to undergo surgical bullectomy...
March 2024: Respirology Case Reports
https://read.qxmd.com/read/38528945/successful-thoracoscopic-operative-approach-for-refractory-pneumothorax-in-interstitial-lung-disease-under-local-anaesthesia
#35
Shinya Yamanaka, Clara So, Naoki Nishimura, Tomoaki Nakamura, Shinsaku Kabemura, Ryosuke Kumagai, Kohei Okafuji, Atsushi Kitamura, Fumitsugu Kojima, Yutaka Tomishima, Torahiko Jinta, Toru Bando
Refractory pneumothorax associated with interstitial lung disease (ILD) remains a challenging condition due to the patient's tolerability and lung compliance that restrict the feasibility of aggressive interventions. Additionally, many cases recur after improvement with treatment, and reports of successful management for this complicated condition are limited. Herein, we report the case of a 60-year-old man with ILD, utilizing home oxygen therapy, who experienced a successful recovery from a surgical intervention under local anaesthesia for pneumothorax...
March 2024: Respirology Case Reports
https://read.qxmd.com/read/38528794/bicuspidisation-of-unicuspid-stenotic-pulmonary-valve-in-a-nine-year-old-male
#36
JOURNAL ARTICLE
Florin Anghel, Catalin Constantin Badiu, Alain J Poncelet
We report the case of a 9-year-old male with severe congenital pulmonary valve stenosis referred to our centre for percutaneous valvotomy. On admission, trans-thoracic echocardiogram confirmed a unicuspid pulmonary valve with a peak/mean pulmonary valve gradient of 91/53 mmHg and a pulmonary annulus of 13.8 mm (-0.8 Z Score). It also showed an enlarged RV (RV/LV ratio 0,9). During cardiac catheterisation, an additional atrial septal defect (secundum) with significant left to right shunt (Qp/Qs > 2) was diagnosed, which was not amenable to percutaneous closure...
March 26, 2024: Cardiology in the Young
https://read.qxmd.com/read/38528758/clinical-midterm-results-of-surgical-aortic-valve-replacement-with-sutureless-valves
#37
JOURNAL ARTICLE
Soonchang Hong, Jung-Woo Son, Yungjin Yoon
BACKGROUND: Sutureless aortic valves may enable shorter procedure times, which benefits patients with elevated surgical risk. We describe the outcomes of patients with aortic stenosis who underwent aortic valve replacement (AVR) using the sutureless Perceval aortic bioprosthesis. METHODS: Data from a retrospective cohort were obtained from a clinical database. The study enrolled patients with symptomatic severe aortic stenosis who underwent surgical AVR with a sutureless bioprosthesis between August 2015 and December 2020...
March 26, 2024: Journal of chest surgery
https://read.qxmd.com/read/38528757/thrombocytopenia-after-aortic-valve-replacement-using-sutureless-valves
#38
JOURNAL ARTICLE
Mil Hoo Kim, Soojin Lee, Juhyun Lee, Seohee Joo, You Kyeong Park, Kang Min Kim, Joon Chul Jung, Hyoung Woo Chang, Jae Hang Lee, Dong Jung Kim, Jun Sung Kim, Kay Hyun Park, Cheong Lim
BACKGROUND: Sutureless valves are widely used in aortic valve replacement surgery, with Perceval valves and Intuity valves being particularly prominent. However, concerns have been raised about postoperative thrombocytopenia with Perceval valves (Corcym, UK). We conducted a comparative analysis with the Intuity valve (Edwards Lifesciences, USA), and assessed how thrombocytopenia affected patient and transfusion outcomes. METHODS: Among 595 patients who underwent aortic valve replacement from June 2016 to March 2023, sutureless valves were used in 53 (Perceval: n=23; Intuity: n=30)...
March 26, 2024: Journal of chest surgery
https://read.qxmd.com/read/38528734/pulmonary-metastasectomy-after-immune-checkpoint-inhibitors-in-malignant-melanoma
#39
JOURNAL ARTICLE
Ichiro Sakanoue, Masatsugu Hamaji, Akihiro Ohsumi, Daisuke Nakajima, Hiroshi Date
The management of malignant melanoma with pulmonary metastases is controversial and occasionally requires multimodality management, including pulmonary metastasectomy after immune checkpoint inhibitors (ICIs). However, limited data are available on these patients. We described a case series of three consecutive patients who underwent pulmonary metastasectomy after ICIs for malignant melanoma and discussed the important characteristics of these patients. After pulmonary metastasectomy, none of the patients had recurrent pulmonary metastases, although extrapulmonary metastases were developed...
March 25, 2024: Asian Cardiovascular & Thoracic Annals
https://read.qxmd.com/read/38527651/prognostic-value-of-kras-g12v-mutation-in-lung-adenocarcinoma-stratified-by-stages-and-radiological-features
#40
JOURNAL ARTICLE
Wangyang Zhu, Han Han, Zelin Ma, Hang Cao, Yueren Yan, Yue Zhao, Chaoqiang Deng, Haomiao Xu, Fangqiu Fu, Fanfan Fan, Yang Zhang, Haiquan Chen
OBJECTS: KRAS G12V is one of the most common KRAS mutation variants in lung adenocarcinoma (LUAD), and yet its prognostic value is still unrevealed. In this study, we investigated the clinicopathological characteristics and prognostic value of KRAS G12V mutation in LUAD. METHODS: Data of 3829 patients who underwent LUAD resection between 2008 and 2020 were collected. Mutations were classified as wild-type, G12V, or non-G12V. The clinicopathological characteristics, postoperative outcomes and recurrence pattern were analyzed among groups...
March 23, 2024: Journal of Thoracic and Cardiovascular Surgery
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