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https://www.readbyqxmd.com/read/29760448/the-gut-microbiota-and-the-brain-gut-kidney-axis-in-hypertension-and-chronic-kidney-disease
#1
REVIEW
Tao Yang, Elaine M Richards, Carl J Pepine, Mohan K Raizada
Crosstalk between the gut microbiota and the host has attracted considerable attention owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly associated with hypertension and is characterized by immune dysregulation, metabolic disorder and sympathetic activation, which are all linked to gut dysbiosis and altered host-microbiota crosstalk. In this Review, we discuss the complex interplay between the brain, the gut, the microbiota and the kidney in CKD and hypertension and explain our brain-gut-kidney axis hypothesis for the pathogenesis of these diseases...
May 14, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29748815/improved-hemodynamic-and-liver-function-in-portal-hypertensive-cirrhotic-rats-after-administration-of-b-pseudocatenulatum-cect-7765
#2
Isabel Gómez-Hurtado, Pedro Zapater, Kevin Portune, Oriol Juanola, Anabel Fernández-Iglesias, José M González-Navajas, Jordi Gracia-Sancho, Yolanda Sanz, Rubén Francés
PURPOSE: Evaluating whether changes in gut microbiota induced by a bifidobacterial strain may have an effect on the hepatic vascular function in portal hypertensive cirrhotic rats. METHODS: Bile duct ligation (BDL) was performed in rats. A subgroup of animals received B. pseudocatenulatum CECT7765 (109  cfu/daily ig.) for 1 week prior to laparotomy. Hemodynamic, biochemical and inflammatory markers were evaluated. Ileal microbiota composition was identified. Statistical analysis was performed...
May 10, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29728993/the-crosstalk-of-gut-microbiota-and-chronic-kidney-disease-role-of-inflammation-proteinuria-hypertension-and-diabetes-mellitus
#3
REVIEW
Mehmet Kanbay, Emine M Onal, Baris Afsar, Tuncay Dagel, Aslihan Yerlikaya, Adrian Covic, Nosratola D Vaziri
Chronic kidney disease (CKD) has been shown to result in profound changes in the composition and functions of the gut microbial flora which by disrupting intestinal epithelial barrier and generating toxic by-products contributes to systemic inflammation and the associated complications. On the other hand, emerging evidence points to the role of the gut microbiota in the development and progression of CKD by provoking inflammation, proteinuria, hypertension, and diabetes. These observations demonstrate the causal interconnection between the gut microbial dysbiosis and CKD...
May 4, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29715498/linking-gut-microbiota-to-cardiovascular-disease-and-hypertension-lessons-from-chronic-kidney-disease
#4
REVIEW
B Meijers, F Jouret, P Evenepoel
Bidirectional interactions exist between the kidneys and the gut. These interactions are commonly referred to as the gut-kidney axis. Chronic kidney disease leads to disturbances of the gut ecosystem. Key features include the increase of protein fermentation at the expense of carbohydrate fermentation and a disrupted epithelial barrier. A disturbed gut ecosystem may contribute to the high burden of cardiovascular disease in patients with CKD. The present review discusses the impact of CKD on the gut microenvironment and provides an update as to how gut dysbiosis and a leaky gut may be linked to accelerated cardiovascular disease and hypertension...
April 28, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29712884/imbalance-of-gut-microbiome-and-intestinal-epithelial-barrier-dysfunction-in-cardiovascular-disease
#5
Judith N Lezutekong, Anish Nikhanj, Gavin Y Oudit
The main function of the intestinal barrier is to regulate the absorption of nutrients, electrolytes, and water from the lumen into circulation and to prevent the entry of pathogenic microorganisms and toxic luminal substances. To maintain this function, an ideal microbiota balance is required and gut microbiota are critical for the intestinal epithelial barrier dysfunction and for the maintenance of physiological homeostasis. There is a demonstrable link between dysbiosis and intestinal dysfunction and diseases such as diabetes, obesity, and cardiovascular disease...
April 30, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29710384/resveratrol-prevents-the-development-of-hypertension-programmed-by-maternal-plus-post-weaning-high-fructose-consumption-through-modulation-of-oxidative-stress-nutrient-sensing-signals-and-gut-microbiota
#6
You-Lin Tain, Wei-Chia Lee, Kay L H Wu, Steve Leu, Julie Y H Chan
SCOPE: High-fructose (HF) intake, oxidative stress, nutrient-sensing signals, and gut microbiota dysbiosis are closely related to the development of hypertension. We investigated whether resveratrol can prevent hypertension induced by maternal plus post-weaning HF diets in adult offspring via the above-mentioned mechanisms. METHODS AND RESULTS: Female Sprague-Dawley rats received either a normal (ND) or 60% high-fructose (HF) diet during gestation and lactation...
April 30, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29685195/microbiota-potential-for-the-treatment-of-sexual-dysfunction
#7
Hassan Tirandaz, Mohammad-Bagher Ebrahim-Habibi, Borhan Moradveisi, Saeid Raoofi, Amir Salehi-Najafabadi, Ebrahim Mohammadi
Inability to have a satisfactory sexual intercourse is a serious problem affecting many people. Despite enormous efforts for developing effective treatments for pathologic conditions associated with sexual malfunction, still a lot of patients do not respond well to such treatments. Microbiota has been shown to affect obesity, diabetes, hypertension, stress/anxiety and sex hormonal disturbances. Nevertheless, no research has concentrated on the link between microbiota and human sexuality or sexual dysfunction...
June 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29662454/the-biological-clock-a-pivotal-hub-in-non-alcoholic-fatty-liver-disease-pathogenesis
#8
REVIEW
Gianluigi Mazzoccoli, Salvatore De Cosmo, Tommaso Mazza
Non-alcoholic fatty liver disease (NAFLD) is the most frequent hepatic pathology in the Western world and may evolve into steatohepatitis (NASH), increasing the risk of cirrhosis, portal hypertension and hepatocellular carcinoma. NAFLD derives from the accumulation of hepatic fat due to discrepant free fatty acid metabolism. Other factors contributing to this are deranged nutrients and bile acids fluxes as well as alterations in nuclear receptors, hormones, and intermediary metabolites, which impact on signaling pathways involved in metabolism and inflammation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29628462/-long-term-dietary-nitrite-and-nitrate-deficiency-causes-metabolic-syndrome-endothelial-dysfunction-and-cardiovascular-death-in-mice
#9
Mika Kina-Tanada, Mayuko Sakanashi, Akira Arasaki, Masato Tsutsui
Nitric oxide (NO) is synthesized not only from L-arginine by NO synthases (NOSs), but also from its inert metabolites, nitrite and nitrate. Green leafy vegetables are abundant in nitrate, however whether or not a deficiency in dietary nitrite/nitrate spontaneously causes disease remains to be clarified. In this study, we tested our hypothesis that long-term dietary nitrite/nitrate deficiency induces metabolic syndrome (MetS) in mice. To this end, we prepared a low nitrite/nitrate diet (LND) consisting of an amino acid-based low nitrite/nitrate chow in which the contents of L-arginine, fat, carbohydrates, protein, and energy were identical with a regular chow, and potable ultrapure water...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/29540276/higher-prevalence-of-fto-gene-risk-genotypes-aa-rs9939609-cc-rs1421085-and-gg-rs17817449-and-saliva-containing-staphylococcus-aureus-in-obese-women-in-croatia
#10
Ana Huđek, Lucija Škara, Barbara Smolkovič, Snježana Kazazić, Sanda Ravlić, Lucia Nanić, Martina Matovinović Osvatić, Jozo Jelčić, Ivica Rubelj, Višnja Bačun-Družina
Obesity is composed of multifunctional interactions of eating habits, behaviors, microbiota, genetics, and other unknown factors. We hypothesize that correlations occur between the fat mass and obesity-associated single nucleotide polymorphisms (FTO SNPs), the composition of microorganisms in the saliva, and life habits in obese women from Zagreb County. Our results of the analysis of 3 FTO SNPs showed a statistically significant positive correlation among the frequencies of the high-risk genotypes AA rs9939609 (P = ...
February 2018: Nutrition Research
https://www.readbyqxmd.com/read/29518493/microbiota-metabolites-pivotal-players-of-cardiovascular-damage-in-chronic-kidney-disease
#11
REVIEW
Carmela Cosola, Maria Teresa Rocchetti, Adamasco Cupisti, Loreto Gesualdo
In chronic kidney disease (CKD), cardiovascular (CV) damage is present in parallel which leads to an increased risk of CV disease. Both traditional and non-traditional risk factors contribute to CV damage in CKD. The systemic role of the microbiota as a central player in the pathophysiology of many organs is progressively emerging in the literature: the microbiota is indeed involved in a complex, bi-directional network between many organs, including the kidney and heart connection, although many of these relationships still need to be elucidated through in-depth mechanistic studies...
April 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29496593/gut-microbiota-in-kidney-disease-and-hypertension
#12
REVIEW
C Antza, S Stabouli, V Kotsis
The human gut microbiota is being composed of more than one hundred trillion microbial cells, including aerobic and anaerobic species as well as gram-positive and negative species. Animal based evidence suggests that the change of normal gut microbiota is responsible for several clinical implications including blood pressure increase and kidney function reduction. Trimethylamine-N-Oxide, short-chain fatty acids and inflammatory factors are originated from the gut microbes and may induce changes in arteries, kidneys and blood pressure...
April 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29469650/prenatal-androgen-exposure-causes-hypertension-and-gut-microbiota-dysbiosis
#13
Shermel Sherman, Nadeen Sarsour, Marziyeh Salehi, Allen Schroering, Blair Mell, Bina Joe, Jennifer W Hill
BACKGROUND: Conditions of excess androgen in women, such as polycystic ovary syndrome (PCOS), often exhibit intergenerational transmission. One way in which the risk for PCOS may be increased in daughters of affected women is through exposure to elevated androgens in utero. Hyperandrogenemic conditions have serious health consequences, including increased risk for hypertension and cardiovascular disease. Recently, gut dysbiosis has been found to induce hypertension in rats, such that blood pressure can be normalized through fecal microbial transplant...
February 22, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29434314/elevated-circulating-levels-of-succinate-in-human-obesity-are-linked-to-specific-gut-microbiota
#14
Carolina Serena, Victoria Ceperuelo-Mallafré, Noelia Keiran, Maria Isabel Queipo-Ortuño, Rosa Bernal, Ricardo Gomez-Huelgas, Mireia Urpi-Sarda, Mónica Sabater, Vicente Pérez-Brocal, Cristina Andrés-Lacueva, Andres Moya, Francisco J Tinahones, Jose Manuel Fernández-Real, Joan Vendrell, Sonia Fernández-Veledo
Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is increased in hypertension, ischemic heart disease, and type 2 diabetes. We aimed to analyze systemic levels of succinate in obesity, a major risk factor for CVD, and its relationship with gut microbiome. We explored the association of circulating succinate with specific metagenomic signatures in cross-sectional and prospective cohorts of Caucasian Spanish subjects...
February 12, 2018: ISME Journal
https://www.readbyqxmd.com/read/29427518/multi-omics-approach-to-elucidate-the-gut-microbiota-activity-metaproteomics-and-metagenomics-connection
#15
Maria Guirro, Andrea Costa, Andreu Gual-Grau, Jordi Mayneris-Perxachs, Helena Torrell, Pol Herrero, Núria Canela, Lluís Arola
Over the last few years, the application of high-throughput meta-omics methods has provided great progress in improving the knowledge of the gut ecosystem and linking its biodiversity to host health conditions, offering complementary support to classical microbiology. Gut microbiota plays a crucial role in relevant diseases such as obesity or cardiovascular disease (CVD), and its regulation is closely influenced by several factors, such as dietary composition. In fact, polyphenol-rich diets are the most palatable treatment to prevent hypertension associated with CVD, although the polyphenol-microbiota interactions have not been completely elucidated...
February 10, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29413959/role-of-gut-microbiota-and-oxidative-stress-in-the-progression-of-non-alcoholic-fatty-liver-disease-to-hepatocarcinoma-current-and-innovative-therapeutic-approaches
#16
REVIEW
Antonella Borrelli, Patrizia Bonelli, Franca Maria Tuccillo, Ira D Goldfine, Joseph L Evans, Franco Maria Buonaguro, Aldo Mancini
Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease in industrialized countries. NAFLD progresses through the inflammatory phase of non-alcoholic steatohepatitis (NASH) to fibrosis and cirrhosis, with some cases developing liver failure or hepatocellular carcinoma (HCC). Liver biopsy remains the gold standard approach to a definitive diagnosis of NAFLD and the distinction between simple steatosis and NASH. The pathogenesis of NASH is still not clear. Several theories have been proposed ranging from the "Two Hit Theory" to the "Multiple Hit Theory"...
May 2018: Redox Biology
https://www.readbyqxmd.com/read/29410236/gut-microbiota-and-probiotics-intervention-a-potential-therapeutic-target-for-management-of-cardiometabolic-disorders-and-chronic-kidney-disease
#17
REVIEW
Marinaldo Pacífico Cavalcanti Neto, Jailane de Souza Aquino, Larissa de Fátima Romão da Silva, Ruanniere de Oliveira Silva, Keyth Sulamitta de Lima Guimarães, Yohanna de Oliveira, Evandro Leite de Souza, Marciane Magnani, Hubert Vidal, José Luiz de Brito Alves
The gut microbiota plays an important role in host metabolism and its dysregulation have been related to cardiometabolic disorders (CMD), such as type 2 diabetes mellitus (T2D), dyslipidemia and arterial hypertension, as well as to chronic kidney diseases (CKD). The implication of the gut microbiota on systemic disorders has been associated with changes in its composition (dysbiosis) as a result of the oxidative unbalance in the body. This alteration may be the result of the adoption of unhealthy lifestyle behavior, including lack of physical activity and fat- or sugar-rich diets, which are largely associated with increased incidence of CMD and CKD...
April 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29378901/gut-as-an-emerging-organ-for-the-treatment-of-diabetes-focus-on-mechanism-of-action-of-bariatric-and-endoscopic-interventions
#18
REVIEW
Martin Haluzík, Helena Kratochvílová, Denisa Haluzíková, Miloš Mráz
Increasing worldwide prevalence of type 2 diabetes mellitus and its accompanying pathologies such as obesity, arterial hypertension and dyslipidemia represents one of the most important challenges of current medicine. Despite intensive efforts, high percentage of patients with type 2 diabetes does not achieve treatment goals and struggle with increasing body weight and poor glucose control. While novel classes of antidiabetic medications such as incretin-based therapies and gliflozins have some favorable characteristics compared to older antidiabetics, the only therapeutic option shown to substantially modify the progression of diabetes or to achieve its remission is bariatric surgery...
April 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29378252/gut-microbiota-hypertension-and-chronic-kidney-disease-recent-advances
#19
REVIEW
Antonio Sircana, Franco De Michieli, Renato Parente, Luciana Framarin, Nicola Leone, Mara Berrutti, Elena Paschetta, Daria Bongiovanni, Giovanni Musso
A large number of different microbial species populates intestine. Extensive research has studied the entire microbial population and their genes (microbiome) by using metagenomics, metatranscriptomics and metabolomic analysis. Studies suggest that the imbalances of the microbial community causes alterations in the intestinal homeostasis, leading to repercussions on other systems: metabolic, nervous, cardiovascular, immune. These studies have also shown that alterations in the structure and function of the gut microbiota play a key role in the pathogenesis and complications of Hypertension (HTN) and Chronic Kidney Disease (CKD)...
January 26, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29351480/mechanistically-different-effects-of-fat-and-sugar-on-insulin-resistance-hypertension-and-gut-microbiota-in-rats
#20
Sara Ramos-Romero, Mercè Hereu, Lidia Atienza, Josefina Casas, Olga Jáuregui, Susana Amézqueta, Gabriel Dasilva, Isabel Medina, Maria Rosa Nogués, Marta Romeu, Josep Lluís Torres
Insulin resistance (IR) and impaired glucose tolerance (IGT) are the first manifestations of diet-induced metabolic alterations leading to type-2 diabetes, while hypertension is the deadliest risk factor of cardiovascular disease. The roles of dietary fat and fructose in the development of IR, IGT and hypertension are controversial. We tested the long-term effects of an excess of fat or sucrose (fructose/glucose) on healthy male Wistar Kyoto (WKY) rats. Fat affects IR and IGT earlier than fructose through low-grade systemic inflammation evidenced by liver inflammatory infiltration, increased levels of plasma interleukin-6, prostaglandin E2 and reduced levels of protective short-chain fatty acids without triggering hypertension...
January 2, 2018: American Journal of Physiology. Endocrinology and Metabolism
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