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https://www.readbyqxmd.com/read/29779677/distinguishing-fecal-appendicular-peritonitis-from-purulent-appendicular-peritonitis
#1
M Mariage, C Sabbagh, T Yzet, H Dupont, A NTouba, J M Regimbeau
INTRODUCTION: Fecal appendicular peritonitis (FAP) is a poorly studied, rare form of acute appendicitis, corresponding to peritoneal inflammation with the presence of feces secondary to ruptured appendix. The purpose of this study was to describe FAP and to compare FAP with purulent appendicular peritonitis (PAP). PATIENTS AND METHODS: This single-center, retrospective study was conducted in consecutive patients to compare the FAP group and the PAP group. The primary endpoint was the 30-day postoperative morbidity and mortality according to the Clavien-Dindo classification...
April 9, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29779069/highly-sensitive-and-selective-detection-of-amoxicillin-using-carbon-quantum-dots-derived-from-beet
#2
Kunjie Wang, Qingjuan Ji, Jialin Xu, Hongxia Li, Deyi Zhang, Xiaoyu Liu, Yujuan Wu, Haiyan Fan
In the present work, we synthesized the carbon quantum dots (CQDs) by one step hydrothermal method using the dried beet powder as the carbon source without additional chemical reagents and functionalization. The as-prepared CQDs are quasi-spherical carbon nanoparticles with diameters of 4-8 nm as well as surface functional groups such as carboxyl and hydroxyl groups, and exhibit good water-solubility, biocompatibility, and strong fluorescence. It is confirmed that amoxicillin (AMO) could enhance the fluorescent intensity of CQDs, the I/I 0 showed a linear correlation between the intensity of fluorescence and the concentration of AMO in a broad range...
May 19, 2018: Journal of Fluorescence
https://www.readbyqxmd.com/read/29776460/validation-of-the-betastar-%C3%A2-advanced-for-beta-lactams-test-kit-for-the-screening-of-bulk-tank-and-tanker-truck-milks-for-the-presence-of-beta-lactam-drug-residues
#3
Andrew Denhartigh, Lindsay Reynolds, Katherine Palmer, Frank Klein, Jennifer Rice, John J Rejman
A validation study was conducted for an immunochromatographic method (BetaStar® Advanced for Beta-lactams) for the detection of beta-lactam residues in raw, commingled bovine milk. The assay detected amoxicillin, ampicillin, cloxacillin, penicillin, cephapirin, and ceftiofur below the U.S. Food and Drug Administration tolerance levels but above the maximum sensitivity thresholds established by the National Conference on Interstate Milk Shipments. The results of internal and independent laboratory dose-response studies employing spiked samples were in agreement...
May 18, 2018: Journal of AOAC International
https://www.readbyqxmd.com/read/29775840/development-of-a-lc-ms-method-for-simultaneous-determination-of-amoxicillin-and-metronidazole-in-human-serum-using-hydrophilic-interaction-chromatography-hilic
#4
Udani L Kathriarachchi, Sagar S Vidhate, Naser Al-Tannak, Alison H Thomson, Michael J J da Silva Neto, David G Watson
A method was developed for the determination of amoxicillin and metronidazole in human serum. The procedure used was hydrophilic interaction chromatography (HILIC) followed by mass spectrometric (MS) detection. Chromatographic separation was achieved on a ZIC-HILIC column and the mobile phase consisted of a mixture of 0.1% (v/v) formic acid in water and 0.1% (v/v) formic acid in acetonitrile. The method was validated with regard to selectivity, accuracy, precision, calibration, lower limit of quantification (LOQ), extraction recovery and matrix effect...
May 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29773358/-antidepressive-agents-and-hyponatremia-a-literature-review-and-a-case-non-case-study-in-the-french-pharmacovigilance-database
#5
Michaël Rochoy, Christina Zakhem-Stachera, Johana Béné, Christophe Berkhout, Sophie Gautier
OBJECTIVE: Most antidepressants have been associated with a risk of hyponatremia in the literature. This effect is not always reported in monographs. The aim of our study was to clarify the difference of increased risk of hyponatremia among various antidepressants. METHODS: Retrospective study of such cases/non-cases from observations recorded in the French national pharmacovigilance between 01/01/2004 and 31/12/2013. We studied all antidepressants marketed in 2014 in France, with a positive control (haloperidol) and a negative one (amoxicillin)...
March 1, 2018: Thérapie
https://www.readbyqxmd.com/read/29771104/-appropriateness-of-antimicrobial-prescriptions-in-the-emergency-department-of-a-tertiary-hospital
#6
L Yunquera-Romero, I Márquez-Gómez, A Henares-López, M J Morales-Lara, C Gallego Fernández, R Asensi-Díez
OBJECTIVE: Antibiotics are widely prescribed in the Emergency Department (ED), representing 26-62% of outpatient antibiotic prescriptions. Around 40% of antibiotic prescriptions in hospitalized patients are inappropriate or unnecessary. The aim of the study was to assess the appropriateness of antibiotic prescriptions according to local empirical antibiotic treatment guidelines, in the ED of a tertiary hospital. METHODS: Observational, retrospective study including patients attending the ED in November 2016, with an antibiotic prescription, excluding those from residents...
May 16, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29770731/antibiotics-mineralization-by-electrochemical-and-uv-based-hybrid-processes-evaluation-of-the-synergistic-effect
#7
Salatiel Wohlmuth da Silva, Alan Nelson Arenhart Heberle, Alexia Pereira Santos, Marco Antônio Siqueira Rodrigues, Valentín Pérez-Herranz, Andréa Moura Bernardes
Antibiotics are not efficiently removed in conventional wastewater treatments. In fact, different Advanced Oxidation Process (AOPs), including ozone, peroxide, UV radiation, among others, are being investigated in the elimination of microcontaminants. Most of AOPs proved to be efficient on the degradation of antibiotics, but the mineralization is on the one hand not evaluated or on the other hand not high. At this work, the UV-based hybrid process, namely Photo-assisted electrochemical Oxidation (PEO), was applied aiming the mineralization of microcontaminants such as the antibiotics Amoxicillin (AMX), Norfloxacin (NOR) and Azithromycin (AZI)...
May 17, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29763981/antibacterial-activity-of-cladanthus-arabicus-and-bubonium-imbricatum-essential-oils-alone-and-in-combination-with-conventional-antibiotics-against-enterobacteriaceae-isolates
#8
Abdellah Aghraz, Qada Benameur, Teresa Gervasi, Loubna Ait Dra, Meriem Hind Ben-Mahdi, Mustapha Larhsini, Mohamed Markouk, Nicola Cicero
Multidrug-resistant bacteria have become common all over the world, necessitating the development of new therapeutic strategies. Synergistic interactions between conventional antibiotics and natural bioactive may have therapeutic benefits in a clinical setting. There are plenty of medicinal plants that have proven efficacy against broad spectrum of microorganisms. The aim of the work was to assess the antibacterial activity of Cladanthus arabicus, a Moroccan medicinal plant, and Bubonium imbricatum, a Moroccan endemic plant...
May 15, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29763726/susceptibility-of-ruminal-bacteria-isolated-from-large-and-small-ruminant-to-multiple-conventional-antibiotics
#9
Abdelfattah Z M Salem, Ameer Khusro, Mona M Y Elghandour, Jaime Olivares-Pérez, Saúl Rojas-Hernandez, Régulo Jiménez-Guillén
The pivotal aim of the present context was to isolate diversified group of bacteria from the ruminants and to evaluate their antibiogram pattern against 22 antibiotics of 14 different classes. The bacterial isolates from small and large ruminant (sheep, cattle, and calves) were isolated from the rumen based on various colonies morphology, and subjected for preliminary antibiotics susceptibility assay using disc diffusion method. The most sensitive isolates (based on zone of inhibition) were selected for determining the minimum inhibitory concentration (MIC) of each antibiotic ranging from 1 to 256 μg/mL...
May 12, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29759804/urinary-tract-infection-by-aerococcus-sanguinicola-an-emerging-opportunistic-pathogen
#10
G Jiménez-Guerra, A Lara-Oya, I Martínez-Egea, J M Navarro-Marí, J Gutiérrez-Fernández
Elderly patients with underlying urological disease have a greater risk of urinary tract infections due to uncommon pathogens. The disease caused by Aerococcus has been underestimated, but mass spectrometry could be a simple method for identifying this pathogen. In this study, we report 2 cases of urinary tract infection by Aerococcus sanguinicola. A descriptive clinical-microbiological study was conducted on the presence of A. sanguinicola causing urinary tract infections. The presence of A. sanguinicola occurred in elderly patients with previous urological disease and a significant count in urine obtained through bladder catheterisation...
May 11, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29756668/amelioration-of-escherichia-coli-induced-endometritis-with-ascorbic-acid-in-non-pregnant-mouse-models
#11
Enitome Evi Bafor, Ikechukwu Onwukpa, Anne Oghenekevwe Itemire, Osemelomen Omoruyi, Ejiroghene Eferoba-Idio, Kevin Odega, Osas Jim Eghianruwa
PROBLEM: Infection-induced endometritis is associated with infertility. The outcome with oral antibiotics remains poor. This study therefore investigates the role of ascorbic acid in resolving endometritis. METHOD OF STUDY: Animals with established oestrus cycles were inoculated with Escherichia coli. Two days post-inoculation, the animals were administered ascorbic acid (10, 100 and 1000 mg/kg) and amoxicillin (500 mg/kg) for 5 days. Other groups included water only and E...
May 14, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29756174/phenotypic-detection-of-clinical-isolates-of-haemophilus-influenzae-with-altered-penicillin-binding-protein-3
#12
A Aguirre-Quiñonero, I C Pérez Del Molino, C García de la Fuente, M C Sanjuán, J Agüero, L Martínez-Martínez
The aims of this study were to determine the correlation of mutations in the ftsI gene (coding for PBP3) of Haemophilus influenzae with aminopenicillin resistance and to evaluate the 2017 European Committee for Antibiotic Susceptibility Testing (EUCAST) guidelines for clinical categorization of ampicillin, amoxicillin, and amoxicillin-clavulanate for strains with mutated PBP3 conferring resistance (rPBP3). A panel of 91 H. influenzae isolates was genetically characterized by sequencing of the fstI gene. For all the studied isolates, a screening with benzylpenicillin 1U (BP1) was carried out and minimum inhibitory concentrations (MICs) of ampicillin, amoxicillin, and amoxicillin-clavulanate were tested and interpreted according to EUCAST recommendations...
May 13, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29754452/part-1-current-prescribing-trends-of-antibiotics-by-dentists-in-australia-from-2013-to-2016
#13
L Teoh, K Stewart, R J Marino, M J McCullough
BACKGROUND: Literature has shown dentists tend to overprescribe antibiotics and do not always prescribe in accordance with recommended guidelines. Unnecessary prescribing is one major factor that contributes to the development of antibiotic resistance. The aim of the present study was to assess the antibacterial prescribing patterns of dentists in Australia from 2013 to 2016. METHODS: Data on dental antibacterial prescriptions dispensed under the Pharmaceutical Benefits Scheme (PBS) from 2013 to 2016 was accessed and prescribing trends analysed...
May 13, 2018: Australian Dental Journal
https://www.readbyqxmd.com/read/29753775/analysis-of-the-impact-of-corticosteroids-adjuvant-treatment-during-experimental-invasive-meningococcal-infection-in-mice
#14
Michaël Levy, Ala-Eddine Deghmane, Myriam Aouiti-Trabelsi, Stéphane Dauger, Albert Faye, Patricia Mariani-Kurkdjian, Muhamed-Kheir Taha
Invasive meningococcal disease (IMD) is usually associated with intense inflammatory response that is correlated with severe infection. Corticosteroids may regulate this inflammatory response through an early but transient induction of IL-10 that is suggested to improve the outcome of IMD. We explored the mechanism of action of corticosteroids as an adjuvant treatment to antibiotics. Transgenic mice expressing the human transferrin were infected by a hyperinvasive meningococcal strain and transcriptomic analysis were then performed in the blood for all conditions of infection and treatment...
May 10, 2018: Steroids
https://www.readbyqxmd.com/read/29750587/the-microbiologic-profile-of-dacryocystitis
#15
Stella Y Chung, Leon Rafailov, Roger E Turbin, Paul D Langer
PURPOSE: Recent studies suggest an increasing incidence of gram-negative bacteria and methicillin-resistant Staphylococcus aureus in dacryocystitis. Since patients are often treated empirically without culture data, a changing microbiologic profile will markedly affect the success of oral treatment. To provide current guidelines for the treatment of this common condition, we investigated the microbiology and antibiogram of dacryocystitis seen at our institution. METHODS: The charts of all patients presenting with acute and/or chronic dacryocystitis in University Hospital, Newark, from 2007 to 2015 were reviewed...
May 11, 2018: Orbit
https://www.readbyqxmd.com/read/29750585/clustering-analysis-of-antibiograms-and-antibiogram-types-of-streptococcus-agalactiae-strains-from-tilapia-in-china
#16
Chan Liu, Juan Feng, Defeng Zhang, Yundan Xie, Anxing Li, Jiangyong Wang, Youlu Su
In view of the changing antibiotic-resistance profiles of Streptococcus agalactiae from tilapia in China, antimicrobial susceptibilities of 75 S. agalactiae strains were determined by the disc diffusion method, and cluster analyses of the antibiograms and antibiogram types were performed. All strains displayed multidrug resistance (MDR). The antimicrobial-resistance rates were highest (>90%) to aminoglycosides, sulfonamides, pipemidic acid, and norfloxacin, followed by penicillin, ampicillin, and ciprofloxacin (26...
May 11, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29744209/the-effect-of-metronidazole-plus-amoxicillin-or-metronidazole-plus-penicillin-v-on-periodontal-pathogens-in-an-in-vitro-biofilm-model
#17
Gabriela Dabija-Wolter, Sundus Saad Al-Zubaydi, Marwan Mansoor Ali Mohammed, Vidar Bakken, Anne Isine Bolstad
A combination of metronidazole (MET) and amoxicillin (AMX) is commonly used as adjunct to mechanical therapy of periodontal disease. The use of broad spectrum antibiotics such as AMX may contribute to development of antibiotic resistance. The aim was to evaluate the in vitro effect of replacing AMX with penicillin V (PV) in combination with MET on a biofilm model. A biofilm model consisting of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Fusobacterium nucleatum was developed. The biofilms were exposed to AMX + MET and PV + MET in two different concentrations...
February 2018: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29743001/emergence-of-quinolone-resistant-shigella-flexneri-in-italy-march-2017
#18
Marta Zatta, Stefano Di Bella, Marina Busetti, Valeria Michelacci, Slawomir Owczarek, Ida Luzzi, Roberto Luzzati
In March 2017, a 45-year-old Italian man who has sex with men was admitted to the Infectious Diseases Department of Trieste Hospital (northeast Italy), because of fever, abdominal pain and dysentery. The patient had neither foreign travel history nor sexual contact with non-Italian partners. Stool cultures grew multidrug-resistant Shigella flexneri (resistant to ampicillin, chloramphenicol, streptomycin, tetracycline, trimethoprim, amoxicillin/clavulanic acid and ciprofloxacin) and whole genome sequencing detailed the resistance features...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29741928/comparative-study-on-antibiotic-resistance-and-dna-profiles-of-salmonella-enterica-serovar-typhimurium-isolated-from-humans-retail-foods-and-the-environment-in-shanghai-china
#19
Zengfeng Zhang, Chenyang Cao, Bin Liu, Xuebin Xu, Yanfei Yan, Shenghui Cui, Sheng Chen, Jianghong Meng, Baowei Yang
We characterized antibiotic resistance profiles, antibiotic resistance-associated genes, and pulsed-field gel electrophoresis (PFGE) patterns of 145 Salmonella enterica serotype Typhimurium isolates from human infections and retail foods that were possibly responsible for salmonellosis outbreaks from 2008 to 2012 in Shanghai, China. Resistance to at least three antibiotics was found in 66.7% of chicken isolates, 76.5% of duck isolates, 77.8% of pork isolates, and 80.5% of human isolates. Seven antibiotic resistance phenotypes were detected in chicken isolates, 16 in pork isolates, 17 in duck isolates, and 50 in human isolates...
May 9, 2018: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29738561/high-dose-versus-standard-dose-amoxicillin-clavulanate-for-clinically-diagnosed-acute-bacterial-sinusitis-a-randomized-clinical-trial
#20
Andrea Matho, Mary Mulqueen, Miyuki Tanino, Aaron Quidort, Jesse Cheung, Jennifer Pollard, Julieta Rodriguez, Supraja Swamy, Brittany Tayler, Gina Garrison, Ashar Ata, Paul Sorum
BACKGROUND: The recommended treatment for acute bacterial sinusitis in adults, amoxicillin with clavulanate, provides only modest benefit. OBJECTIVE: To see if a higher dose of amoxicillin will lead to more rapid improvement. DESIGN, SETTING, AND PARTICIPANTS: Double-blind randomized trial in which, from November 2014 through February 2017, we enrolled 315 adult outpatients diagnosed with acute sinusitis in accordance with Infectious Disease Society of America guidelines...
2018: PloS One
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