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https://www.readbyqxmd.com/read/29165549/prognostic-impacts-of-rho-kinase-activity-in-circulating-leucocytes-in-patients-with-vasospastic-angina
#1
Taro Nihei, Jun Takahashi, Kiyotaka Hao, Yoku Kikuchi, Yuji Odaka, Ryuji Tsuburaya, Kensuke Nishimiya, Yasuharu Matsumoto, Kenta Ito, Satoshi Miyata, Yasuhiko Sakata, Hiroaki Shimokawa
Aims: Rho-kinase activity in circulating leucocytes is a useful biomarker for diagnosis and disease activity assessment of vasospastic angina (VSA). The present study aimed to examine the long-term prognostic impact of Rho-kinase activity in circulating leucocytes in VSA patients. Methods and results: We prospectively enrolled 174 consecutive patients with VSA and 50 non-VSA patients, in whom we measured Rho-kinase activity in circulating leucocytes, and they were followed for a median of 16 months...
November 20, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29165120/high-prevalence-of-dental-fluorosis-among-adolescents-is-a-growing-concern-a-school-based-cross-sectional-study-from-southern-india
#2
Anand Verma, Bharatesh K Shetty, Vasudeva Guddattu, Mehul K Chourasia, Prachi Pundir
BACKGROUND: Fluorosis, caused by ingestion of excessive amount of fluoride through food or water, is a major public health problem in India. This study was undertaken to quantify the dental fluorosis burden among school going adolescents and to find factors associated with dental fluorosis in Kolar taluka, Karnataka, India. METHODS: A total of 1026 high school adolescents (12-17 years) were enrolled from different schools selected by stratified sampling method. Dental examination was done to record Dean's fluorosis index, and socio-demographic, food consumption and oral hygiene data were recorded using a pre-tested structured questionnaire...
April 4, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29164615/arhgef19-interacts-with-braf-to-activate-mapk-signaling-during-the-tumorigenesis-of-non-small-cell-lung-cancer
#3
Yingchang Li, Zhihua Ye, Shuai Chen, Zhiwen Pan, Qianghua Zhou, Yi-Zhuo Li, Wen-di Shuai, Chun-Mei Kuang, Qi-Hua Peng, Wei Shi, Xueli Mao, Ran-Yi Liu, Wenlin Huang
Rho guanine nucleotide exchange factors (RhoGEFs) are proteins that activate Rho GTPases in response to extracellular stimuli and regulate various biologic processes. ARHGEF19, one of RhoGEFs, was reported to activate RhoA in the Wnt-PCP pathway controlling convergent extension in Xenopus gastrulation. The goal of this study was to identify the role and molecular mechanisms of ARHGEF19 in the tumorigenesis of non-small cell lung cancer (NSCLC). ARHGEF19 expression was significantly elevated in NSCLC tissues, and ARHGEF19 levels were significantly associated with lymph node status, distant metastasis and TNM stage; Patients with high ARHGEF19 levels had poor overall survival (OS) and progression-free survival (PFS)...
November 22, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29164380/correlation-between-the-availability-of-dopamine-transporter-and-olfactory-function-in-healthy-subjects
#4
Kyoungjune Pak, Keunyoung Kim, Myung Jun Lee, Jae Meen Lee, Bum Soo Kim, Seong-Jang Kim, In Joo Kim
OBJECTIVES: Olfactory dysfunction in Parkinson's disease is usually prodromal to other symptoms. In this study, we aimed to explore the association of olfactory function with the availabilities of striatal dopamine transporter (DAT) in healthy subjects. METHODS: Data used in the preparation of this article were obtained from Parkinson's Progression Markers Initiative database ( www.ppmi-info.org/data ). The study population consisted of healthy controls with screening (123)I-FP-CIT single photon emission tomography (SPECT)...
November 21, 2017: European Radiology
https://www.readbyqxmd.com/read/29163901/violations-of-l%C3%A3-wenstein-s-rule-in-zeolites
#5
Rachel E Fletcher, Sanliang Ling, Ben Slater
Zeolites, microporous aluminosilicates, are amongst the most widely used catalysts in the petrochemical industry. Zeolite catalytic functionality is influenced by the location of tetrahedral alumina and associated counter-cations in the aluminosilicate framework, yet little is definitively known about the factors that govern the framework aluminium arrangement. It is generally accepted that all zeolites obey Löwenstein's rule of "aluminium avoidance", and that -Al-O-Al- bond formation is forbidden. Here, we describe an unprecedented screening of aluminium distribution in catalytically active zeolite SSZ-13 (CHA) in both its protonated and sodium-containing forms, H-SSZ-13 and Na-SSZ-13, using density functional theory (DFT)...
November 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29163338/radial-peripapillary-capillary-network-in-patients-with-retinitis-pigmentosa-an-optical-coherence-tomography-angiography-study
#6
Rodolfo Mastropasqua, Enrico Borrelli, Luca Agnifili, Lisa Toto, Luca Di Antonio, Alfonso Senatore, Michele Palmieri, Alessandro D'Uffizi, Paolo Carpineto
Purpose: To investigate radial peripapillary capillary (RPC) network in patients affected by retinitis pigmentosa (RP). Methods: Eleven patients (22 eyes) with previous diagnosis of RP and 16 age-matched healthy subjects (16 eyes) were enrolled. The diagnosis of RP was made based on both clinical features and electrophysiological examination. All patients underwent a complete ophthalmologic examination, including optical coherence tomography angiography and visual field (VF)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29162819/exocytosis-coordinated-mechanisms-for-tip-growth-underlie-pollen-tube-growth-guidance
#7
Nan Luo, An Yan, Gang Liu, Jingzhe Guo, Duoyan Rong, Masahiro M Kanaoka, Zhen Xiao, Guanshui Xu, Tetsuya Higashiyama, Xinping Cui, Zhenbiao Yang
Many tip-growing cells are capable of responding to guidance cues, during which cells precisely steer their growth toward the source of guidance signals. Though several players in signal perception have been identified, little is known about the downstream signaling that controls growth direction during guidance. Here, using combined modeling and experimental studies, we demonstrate that the growth guidance of Arabidopsis pollen tubes is regulated by the signaling network that controls tip growth. Tip-localized exocytosis plays a key role in this network by integrating guidance signals with the ROP1 Rho GTPase signaling and coordinating intracellular signaling with cell wall mechanics...
November 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/29162472/-self-perception-of-disease-in-patients-with-chronic-diseases
#8
L Adrián-Arrieta, J M Casas-Fernández de Tejerina
OBJECTIVE: The aim of this study is to assess the self-perception of disease by patients with chronic diseases and determine factors related to their perception of disease. MATERIAL AND METHODS: Cross-sectional descriptive study performed between September 2014 and April 2015 in nine (6 urban and 3 rural) Health Centres of Navarra, Spain. The participants were recruited by convenience sampling of 196 patients aged over 65 years with at least one chronic disease...
November 18, 2017: Semergen
https://www.readbyqxmd.com/read/29162447/co-administration-of-liposomal-fasudil-and-tissue-plasminogen-activator-ameliorated-ischemic-brain-damage-in-occlusion-model-rats-prepared-by-photochemically-induced-thrombosis
#9
Tatsuya Fukuta, Yosuke Yanagida, Tomohiro Asai, Naoto Oku
Delivery of neuroprotectants with liposomes has been shown to be effective for the treatment of ischemic stroke. We have recently revealed that intravenous administration of liposomal fasudil (Fasudil-Lip), a Rho-kinase inhibitor, prior to thrombolysis with tissue plasminogen activator (t-PA) can extend the narrow therapeutic time window (TTW) of t-PA. In the present study, we examined the influence of t-PA treatment on liposomal accumulation into the ischemic region and cerebroprotective effect of combined treatment with Fasudil-Lip and t-PA performed at the same timing after the onset of ischemia in middle cerebral artery occlusion (MCAO) prepared by photochemically induced thrombosis...
November 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29162160/high-urinary-interleukin-2-in-late-post-transplant-period-portends-a-risk-of-decline-in-kidney-allograft-function-a-preliminary-study
#10
Andriy V Trailin, Marina V Pleten, Tetyana I Ostapenko, Nadiia F Iefimenko, Olexandr S Nykonenko
BACKGROUND: Predictive factors for the rate of decline in kidney allograft function beyond the first post-transplant year have not been thoroughly studied. We aimed to determine whether a single measurement of serum and urinary interleukin 2, interleukin 8 and interleukin 10 at 1-15 years after kidney transplantation could predict a decline in estimated glomerular filtration rate (eGFR) over a 2-year period. RESULTS: Greater serum concentrations of interleukin 8 and interleukin 10 in 30 recipients of kidney allograft at enrollment were associated with lower eGFR after 1 year (beta = - 0...
November 21, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29161943/analysis-of-sequence-divergence-in-redfin-cypriniformes-cyprinidae-tribolodon-based-on-mtdna-and-ndna-markers-with-inferences-in-systematics-and-genetics-of-speciation
#11
Anna O Zolotova, Yuri Ph Kartavtsev
To clarify relationship of species of the genus Tribolodon in the Russian part of their distribution ranges, two mitochondrial markers (Co-1 and Cyt-b), a nuclear marker (Rho), and a gene marker of rDNA internal transcribed spacer (ITS-1,2) were used. Depending on the marker, different numbers of species groups were detected by the ABGD method, but in combination with the analysis of phylograms, these data generally support the known species clusters and regional intraspecies groups. A complex analysis of sequences from three redfin species within the area of the study, based on four marker genes and using the methods of molecular phylogenetics, ordination of genetic distances, recombinant analysis, and population genetic approaches, has revealed clusters of three commonly recognized species, regional intraspecific groups or individuals of local populations, and few hybrid individuals...
November 21, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/29161290/comparative-analysis-of-weighted-gene-co-expression-networks-in-human-and-mouse
#12
Marius Eidsaa, Lisa Stubbs, Eivind Almaas
The application of complex network modeling to analyze large co-expression data sets has gained traction during the last decade. In particular, the use of the weighted gene co-expression network analysis framework has allowed an unbiased and systems-level investigation of genotype-phenotype relationships in a wide range of systems. Since mouse is an important model organism for biomedical research on human disease, it is of great interest to identify similarities and differences in the functional roles of human and mouse orthologous genes...
2017: PloS One
https://www.readbyqxmd.com/read/29161152/proliferative-cells-isolated-from-the-adult-human-peripheral-retina-only-transiently-upregulate-key-retinal-markers-upon-induced-differentiation
#13
Erik O Johnsen, Rebecca C Frøen, Ole Kristoffer Olstad, Bjørn Nicolaissen, Goran Petrovski, Morten C Moe, Agate Noer
Purpose/Aim: The adult human retina has limited regenerative potential, and severe injury will result in permanent damage. Lower vertebrates handle retinal injury by activating neural stem cells (NSCs) in the ciliary marginal zone (CMZ). Müller glia-like cells expressing markers of NSCs are also present in the peripheral retina (PR) of the adult human eye, leading to the hypothesis that a CMZ-like zone might exists also in humans. In order to shed further light on this hypothesis we investigated the in vitro differentiation potential of proliferative cells isolated from the adult human PR towards a retinal phenotype...
November 21, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29159779/simultaneous-whole-body-and-breast-18f-fdg-pet-mri-examinations-in-patients-with-breast-cancer-a-comparison-of-apparent-diffusion-coefficients-and-maximum-standardized-uptake-values
#14
Michiro Sasaki, Mitsuhiro Tozaki, Kazunori Kubota, Wakana Murakami, Daisuke Yotsumoto, Yasuaki Sagara, Yasuyo Ohi, Shunichi Oosako, Yoshiaki Sagara
PURPOSE: To compare standardized uptake value (SUV) and apparent diffusion coefficient (ADC) values acquired using a PET/MRI scanner in breast cancer patients. MATERIALS AND METHODS: Whole-body PET/MRI and breast PET/MRI were performed in 108 consecutive patients. Ninety-four patients who had a total of 100 breast cancers were analyzed. SUVmax and ADCmean acquired using breast PET/MRI were compared with pathologic prognostic factors. RESULTS: All the lesions were visually detectable using PET and diffusion-weighted imaging (DWI) on breast PET/MRI; however, lesions were visually undetectable on whole-body DWI in 13 patients (13%) or on whole-body PET in 7 patients (7%)...
November 20, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29159669/thyroid-hormones-and-commonly-cited-symptoms-of-overtraining-in-collegiate-female-endurance-runners
#15
Justin X Nicoll, Disa L Hatfield, Kathleen J Melanson, Christopher S Nasin
PURPOSE: Overtraining syndrome (OTS) is reported in endurance sports. Thyroid hormones (TH) regulate metabolism, mood, and energy production, and may play a role in OTS of endurance athletes. The purpose of this study was to investigate relationships in TH and symptoms of OTS in track and field endurance runners (ER). METHODS: Sixteen female track and field middle distance (MD; n = 9; age: 20.2 ± 1.5 years; ht: 167.86 ± 5.04 cm; body-mass: 57.97 ± 5...
November 20, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29159523/quantitating-whole-lesion-tumor-biology-in-rectal-cancer-mri-taking-a-lesson-from-fdg-pet-tumor-metrics
#16
Marc J Gollub, Andreas M Hotker, Kaitlin M Woo, Yousef Mazaheri, Mithat Gonen
PURPOSE: To determine the value of novel whole tumor metrics in DWI-MRI and DCE-MRI of rectal cancer treatment assessment. MATERIALS AND METHODS: This retrospective study included 24 uniformly treated patients with rectal adenocarcinoma who underwent MRI including diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) sequences, before and after chemoradiotherapy. Two experienced readers independently measured tumor volume and apparent diffusion coefficient (ADC) on DWI-MRI and tumor volume and transfer constant K (trans) on DCE-MRI...
November 20, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29159155/how-to-escape-stentriever-wedging-in-an-open-cell-carotid-stent-during-mechanical-thrombectomy-for-tandem-cervical-internal-carotid-artery-and-middle-cerebral-artery-occlusion
#17
Hae Won Rho, Won Ki Yoon, Jang Hun Kim, Jong Hyun Kim, Taek Hyun Kwon
We present 2 cases of complicated mechanical thrombectomy involving tandem cervical internal carotid artery and middle cerebral artery occlusion using the Solitaire FR stent and simultaneous carotid stent angioplasty. During the procedures, the Solitaire stents containing the thrombus were wedged into the open-cell carotid stents, which were already deployed for proximal flow restoration. We describe the methods used to avoid and overcome such complications.
September 2017: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/29158989/activation-of-rho-kinase-and-focal-adhesion-kinase-regulates-the-organization-of-stress-fibers-and-focal-adhesions-in-the-central-part-of-fibroblasts
#18
Kazuo Katoh
Specific regulation and activation of focal adhesion kinase (FAK) are thought to be important for focal adhesion formation, and activation of Rho-kinase has been suggested to play a role in determining the effects of FAK on the formation of stress fibers and focal adhesions. To clarify the role of FAK in stress fiber formation and focal adhesion organization, the author examined the formation of new stress fibers and focal adhesions by activation of Rho-kinase in FAK knockout (FAK(-/-)) fibroblasts. FAK(-/-) cells were elliptical in shape, and showed reduced numbers of stress fibers and focal adhesions in the central part of the cells along with large focal adhesions in the peripheral regions...
2017: PeerJ
https://www.readbyqxmd.com/read/29158718/effects-of-chronic-%C3%AE-9-tetrahydrocannabinol-treatment-on-rho-rho-kinase-signalization-pathway-in-mouse-brain
#19
Halil Mahir Kaplan, Percin Pazarci
Δ(9)-Tetrahydrocannabinol (Δ(9)-THC) shows its effects by activating cannabinoid receptors which are on some tissues and neurons. Cannabinoid systems have role on cell proliferation and development of neurons. Furthermore, it is interesting that cannabinoid system and rho/rho-kinase signalization pathway, which have important role on cell development and proliferation, may have role on neuron proliferation and development together. Thus, a study is planned to investigate rhoA and rho-kinase enzyme expressions and their activities in the brain of chronic Δ(9)-THC treated mice...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29157138/fast-cycling-rho-gtpases
#20
Pontus Aspenström
The Rho GTPases were discovered more than 30 years ago, and they were for a long time considered to follow simple cycling between GDP-bound and GTP-bound conformations, as for the Ras subfamily of small GTPases. The Rho GTPases consist of 20 members, but at least 10 of these do not follow this classical GTPase cycle. Thus, based on their kinetic properties, these Rho GTPases can instead be classified as atypical. Some of these atypical Rho GTPases do not hydrolyze GTP, and some have significantly increased intrinsic GDP/GTP exchange activity...
November 20, 2017: Small GTPases
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