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https://www.readbyqxmd.com/read/28636296/-follow-up-of-the-long-term-cancer-survivor
#1
Francesco Sciotto, Céline Py, Petros Tsantoulis
Improvements in diagnosis and treatments explain the notable increase in patients chronically affected or recovering from cancer. This is a fragile population, who is physically, psychologically and socially affected by the consequences of the disease and the associated treatments. In addition to detecting a possible relapse, oncologists and primary care physicians have to deal with a variety of issues like psychological distress, sexual dysfunction, cardiotoxicity, cognitive impairment, fatigue and, in some cases, a second primary cancer...
May 17, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28635482/diagnosis-and-management-of-myasthenia-gravis
#2
Christopher Barber
Myasthenia gravis is a rare long-term neurological condition that is characterised by fluctuating skeletal muscle weakness and fatigue, as well as respiratory difficulties. It is both an acquired autoimmune disease and a chronic neuromuscular disorder. Because of its rarity, myasthenia gravis is relatively unknown and may be unfamiliar to many nurses. While there are various types of myasthenia, this article focuses on myasthenia gravis, exploring its symptoms, diagnosis and treatment, and examining the nurse's role in managing the condition...
June 21, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28617377/-pharmacological-treatment-of-patients-with-chronic-fatigue-syndrome
#3
O S Glazachev, Е N Dudnik, E E Zagaynaya
AIM: To evaluate the efficacy and safety of human placenta extract - laennec infusions in the treatment of patients with confirmed diagnosis of 'Chronic fatigue syndrome' (CFS). MATERIAL AND METHODS: The study included 38 patients with CFS, randomized into 2 groups: patients of the experimental group (EG, n=24) were treated with 10 intravenous laennec infusions, 4 ml each, 2 times/week, for 5 weeks. The control group (CG) consisted of 14 patients. Treatment efficacy evaluated by the severity of chronic fatigue ('The degree of chronic fatigue' questionnaire), state anxiety, depression and anger (Spilberger test) and quality of life (SF-36v2), exercise tolerance (cardiopulmonary exercise test with gas analysis), blood parameters were assessed before, after, and 5 weeks of follow-up...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28616125/mechanisms-of-neurotoxic-symptoms-as-a-result-of-breast-cancer-and-its-treatment-considerations-on-the-contribution-of-stress-inflammation-and-cellular-bioenergetics
#4
REVIEW
Tamara E Lacourt, Cobi J Heijnen
PURPOSE OF REVIEW: Breast cancer and its treatment are associated with a range of neurotoxic symptoms, such as fatigue, cognitive impairment, and pain. Although these symptoms generally subside after treatment completion, they become chronic in a significant subset of patients. We here summarize recent findings on neuroinflammation, stress, and mitochondrial dysfunction as mechanistic pathways leading to neurotoxic symptom experience in breast cancer patients and survivors. RECENT FINDINGS: Neuroinflammation related to stress or cancer treatment and stress resulting from diagnosis, treatment, or (cancer-related) worrying are important predictors of a neurotoxic symptom experience, both during and after treatment for breast cancer...
2017: Current Breast Cancer Reports
https://www.readbyqxmd.com/read/28606800/physical-exercise-positively-influences-breast-cancer-evolution
#5
REVIEW
Kalliopi Adraskela, Eleftheria Veisaki, Michael Koutsilieris, Anastassios Philippou
Breast cancer is one of the most commonly diagnosed types of cancer in women. Its pathogenesis involves genetic, hormonal, and environmental factors. A large body of evidence indicates that physical activity has positive effects on every aspect of breast cancer evolution, including prevention, medical treatment, and aftercare clinical settings. Thus, different types of exercise can influence the prevention and progression of the disease through several common mechanisms, such as reduction of insulin resistance and improvement of immunity and cardiovascular function...
May 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28606498/long-term-follow-up-after-cognitive-behaviour-therapy-for-chronic-fatigue-syndrome
#6
Anthonie Janse, Stephanie Nikolaus, Jan F Wiborg, Marianne Heins, Jos W M van der Meer, Gijs Bleijenberg, Marcia Tummers, Jos Twisk, Hans Knoop
OBJECTIVE: Cognitive behaviour therapy (CBT) is an effective treatment for chronic fatigue syndrome (CFS). Main aim was to determine whether treatment effects were maintained up to 10years after treatment. METHODS: Participants (n=583) of previously published studies on the effects of CBT for CFS were contacted for a long-term follow-up assessment. They completed questionnaires on main outcomes fatigue severity (CIS) and physical functioning (SF-36). The course of these outcomes since post-treatment assessment was examined using mixed model analyses...
June 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28605207/kinesiophobia-and-maladaptive-coping-strategies-prevent-improvements-in-pain-catastrophizing-following-pain-neuroscience-education-in-fibromyalgia-chronic-fatigue-syndrome-an-explorative-study
#7
Anneleen Malfliet, Jessica Van Oosterwijck, Mira Meeus, Barbara Cagnie, Lieven Danneels, Mieke Dolphens, Ronald Buyl, Jo Nijs
Many patients with chronic fatigue syndrome(CFS) and/or fibromyalgia(FM) have little understanding of their condition, leading to maladaptive pain cognitions and coping strategies. These should be tackled during therapy, for instance by pain neurophysiology education (PNE). Although positive effects of PNE are well-established, it remains unclear why some patients benefit more than others. This paper aims at exploring characteristics of patients responding poor to PNE to further improve its effectiveness. Data from two RCT's were pooled to search for baseline predictors...
June 12, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28602585/janus-kinase-2-inhibitor-fedratinib-in-patients-with-myelofibrosis-previously-treated-with-ruxolitinib-jakarta-2-a-single-arm-open-label-non-randomised-phase-2-multicentre-study
#8
Claire N Harrison, Nicolaas Schaap, Alessandro M Vannucchi, Jean-Jacques Kiladjian, Ramon V Tiu, Pierre Zachee, Eric Jourdan, Elliott Winton, Richard T Silver, Harry C Schouten, Francesco Passamonti, Sonja Zweegman, Moshe Talpaz, Joanne Lager, Zhenming Shun, Ruben A Mesa
BACKGROUND: Myelofibrosis is a chronic myeloproliferative neoplasm characterised by splenomegaly, cytopenias, bone marrow fibrosis, and debilitating symptoms including fatigue, weight loss, and bone pain. Mutations in Janus kinase-2 (JAK2) occur in approximately 50% of patients. The only approved JAK2 inhibitor for myelofibrosis is the dual JAK1 and JAK2 inhibitor, ruxolitinib. 58-71% of patients treated with ruxolitinib in clinical trials so far have not achieved the primary endpoint of 35% or more reduction in spleen volume from baseline assessed by MRI or CT...
June 8, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28600789/improving-the-management-of-psoriatic-arthritis-and-axial-spondyloarthritis-roundtable-discussions-with-healthcare-professionals-and-patients
#9
REVIEW
Marco Garrido-Cumbrera, Ottfrid Hillmann, Raj Mahapatra, David Trigos, Petra Zajc, Luisa Weiss, Galya Bostynets, Laure Gossec, Laura C Coates
Psoriatic arthritis (PsA) and axial spondyloarthritis (AxSpA) are both chronic, inflammatory conditions that result in a substantial burden of disease and reduced quality of life for patients. Patient involvement in developing optimal disease management strategies, including defining appropriate goals, therapies, and treatment options, as well as in setting policy priorities and agendas, is key. A working group of patient organization representatives and rheumatologists explored what patients consider to be unmet needs, important treatment gaps, and future priorities in PsA and AxSpA management...
June 9, 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/28597471/gabapentin-for-chronic-neuropathic-pain-in-adults
#10
REVIEW
Philip J Wiffen, Sheena Derry, Rae F Bell, Andrew Sc Rice, Thomas Rudolf Tölle, Tudor Phillips, R Andrew Moore
BACKGROUND: Gabapentin is commonly used to treat neuropathic pain (pain due to nerve damage). This review updates a review published in 2014, and previous reviews published in 2011, 2005 and 2000. OBJECTIVES: To assess the analgesic efficacy and adverse effects of gabapentin in chronic neuropathic pain in adults. SEARCH METHODS: For this update we searched CENTRAL), MEDLINE, and Embase for randomised controlled trials from January 2014 to January 2017...
June 9, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28596045/comorbidity-in-chronic-fatigue-syndrome-myalgic-encephalomyelitis-a-nationwide-population-based-cohort-study
#11
Jesús Castro-Marrero, Mónica Faro, Luisa Aliste, Naia Sáez-Francàs, Natalia Calvo, Alba Martínez-Martínez, Tomás Fernández de Sevilla, Jose Alegre
BACKGROUND: Previous studies have shown evidence of comorbid conditions in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). OBJECTIVE: To estimate the prevalence of comorbidities and assess their associations using a nationwide population-based database of a Spanish CFS/ME cohort. METHOD: A nationally representative, retrospective, cross-sectional cohort study (2008-2015) assessed 1757 Spanish subjects who met both the 1994 Centers for Disease Control and Prevention/Fukuda definition and 2003 Canadian Criteria for CFS/ME...
April 21, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28592308/examining-clinical-similarities-between-myalgic-encephalomyelitis-chronic-fatigue-syndrome-and-d-lactic-acidosis-a-systematic-review
#12
REVIEW
Amy Wallis, Michelle Ball, Sandra McKechnie, Henry Butt, Donald P Lewis, Dorothy Bruck
BACKGROUND: The pursuit for clarity in diagnostic and treatment pathways for the complex, chronic condition of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) continues. This systematic review raises a novel question to explore possible overlapping aetiology in two distinct conditions. Similar neurocognitive symptoms and evidence of D-lactate producing bacteria in ME/CFS raise questions about shared mechanisms with the acute condition of D-lactic acidosis (D-la). METHODS: D-la case reports published between 1965 and March 2016 were reviewed for episodes describing both neurological symptoms and high D-lactate levels...
June 7, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28589261/nonmotor-symptoms-in-patients-with-spinocerebellar-ataxia-type-10
#13
Adriana Moro, Renato P Munhoz, Mariana Moscovich, Walter O Arruda, Salmo Raskin, Laura Silveira-Moriyama, Tetsuo Ashizawa, Hélio A G Teive
Nonmotor symptoms (NMS) have been described in several neurodegenerative diseases but have not been systematically evaluated in spinocerebellar ataxia type 10 (SCA10). The objective of the study is to compare the frequency of NMS in patients with SCA10, Machado-Joseph disease (MJD), and healthy controls. Twenty-eight SCA10, 28 MJD, and 28 healthy subjects were prospectively assessed using validated screening tools for chronic pain, autonomic symptoms, fatigue, sleep disturbances, psychiatric disorders, and cognitive function...
June 6, 2017: Cerebellum
https://www.readbyqxmd.com/read/28589117/xmrv-and-public-health-the-retroviral-genome-is-not-a-suitable-template-for-diagnostic-pcr-and-its-association-with-myalgic-encephalomyelitis-chronic-fatigue-syndrome-appears-unreliable
#14
Simona Panelli, Lorenzo Lorusso, Alessandro Balestrieri, Giuseppe Lupo, Enrica Capelli
A few years ago, a highly significant association between the xenotropic murine leukemia virus-related virus (XMRV) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a complex debilitating disease of poorly understood etiology and no definite treatment, was reported in Science, raising concern for public welfare. Successively, the failure to reproduce these findings, and the suspect that the diagnostic PCR was vitiated by laboratory contaminations, led to the retraction of the paper. Notwithstanding, XMRV continued to be the subject of researches and public debates...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28588427/evaluation-of-anti-fatigue-property-of-the-extruded-product-of-cereal-grains-mixed-with-cordyceps-militaris-on-mice
#15
Lei Zhong, Liyan Zhao, Fangmei Yang, Wenjian Yang, Yong Sun, Qiuhui Hu
BACKGROUND: Fatigue is a biological phenomenon that involves a feeling of extreme physical or mental tiredness that could potentially cause some severe chronic diseases. Recently, diet therapy has provided a new alternative to alleviate physical fatigue. In our previous study, addition of Cordyceps militaris (C. militaris) into an extruded product was shown to provide high nutrition and unique flavors; however, little is known whether this product has some scientific evidence regarding anti-fatigue property...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28576141/adult-patients-experiences-of-nhs-specialist-services-for-chronic-fatigue-syndrome-cfs-me-a-qualitative-study-in-england
#16
Jessica Broughton, Sarah Harris, Lucy Beasant, Esther Crawley, Simon M Collin
BACKGROUND: Few studies have explored patients' experiences of treatment for CFS/ME. This study aims to fill this gap by capturing the perspective of patients who have been treated by NHS specialist CFS/ME services in England. METHODS: Semi-structured interviews were conducted during the period June-September 2014 with 16 adults who were completing treatment at one of three outpatient NHS specialist CFS/ME services. Interviews were analysed thematically using constant comparison techniques, with particular attention paid to contrasting views...
June 2, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28574985/economic-evaluation-of-multidisciplinary-rehabilitation-treatment-versus-cognitive-behavioural-therapy-for-patients-with-chronic-fatigue-syndrome-a-randomized-controlled-trial
#17
Desirée Vos-Vromans, Silvia Evers, Ivan Huijnen, Albère Köke, Minou Hitters, Nieke Rijnders, Menno Pont, André Knottnerus, Rob Smeets
BACKGROUND: A multi-centre RCT has shown that multidisciplinary rehabilitation treatment (MRT) is more effective in reducing fatigue over the long-term in comparison with cognitive behavioural therapy (CBT) for patients with chronic fatigue syndrome (CFS), but evidence on its cost-effectiveness is lacking. AIM: To compare the cost-effectiveness of MRT versus CBT for patients with CFS from a societal perspective. METHODS: A multi-centre randomized controlled trial comparing MRT with CBT was conducted among 122 patients with CFS diagnosed using the 1994 criteria of the Centers for Disease Control and Prevention and aged between 18 and 60 years...
2017: PloS One
https://www.readbyqxmd.com/read/28565736/-predictors-of-fatigue-among-individuals-with-primary-immune-thrombocytopenia-in-china
#18
Y Li, M E Lyu, Y T Hao, B Y Sun, Y T Huang, R F Fu, F Xue, X F Liu, L Zhang, R C Yang
Objective: To study the fatigue symptoms of adult patients with primary immune thrombocytopenia (ITP) and to analyze the possible factors that affect the severity of fatigue. Methods: Eligible adult patients with ITP who admitted to Institute of Hematology & Blood Diseases Hospital were enrolled in this study and the questionnaires including a Chinese version of the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) , the Pittsburgh sleep quality index (PSQI) , the Hospital Anxiety and Depression scale (HADS) and demographic information were completed...
May 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28564569/sofosbuvir-velpatasvir-and-voxilaprevir-for-previously-treated-hcv-infection
#19
RANDOMIZED CONTROLLED TRIAL
Marc Bourlière, Stuart C Gordon, Steven L Flamm, Curtis L Cooper, Alnoor Ramji, Myron Tong, Natarajan Ravendhran, John M Vierling, Tram T Tran, Stephen Pianko, Meena B Bansal, Victor de Lédinghen, Robert H Hyland, Luisa M Stamm, Hadas Dvory-Sobol, Evguenia Svarovskaia, Jie Zhang, K C Huang, G Mani Subramanian, Diana M Brainard, John G McHutchison, Elizabeth C Verna, Peter Buggisch, Charles S Landis, Ziad H Younes, Michael P Curry, Simone I Strasser, Eugene R Schiff, K Rajender Reddy, Michael P Manns, Kris V Kowdley, Stefan Zeuzem
BACKGROUND: Patients who are chronically infected with hepatitis C virus (HCV) and who do not have a sustained virologic response after treatment with regimens containing direct-acting antiviral agents (DAAs) have limited retreatment options. METHODS: We conducted two phase 3 trials involving patients who had been previously treated with a DAA-containing regimen. In POLARIS-1, patients with HCV genotype 1 infection who had previously received a regimen containing an NS5A inhibitor were randomly assigned in a 1:1 ratio to receive either the nucleotide polymerase inhibitor sofosbuvir, the NS5A inhibitor velpatasvir, and the protease inhibitor voxilaprevir (150 patients) or matching placebo (150 patients) once daily for 12 weeks...
June 1, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28554371/the-assessment-of-fatigue-psychometric-qualities-and-norms-for-the-checklist-individual-strength
#20
M Worm-Smeitink, M Gielissen, L Bloot, H W M van Laarhoven, B G M van Engelen, P van Riel, G Bleijenberg, S Nikolaus, H Knoop
OBJECTIVE: The Checklist Individual Strength (CIS) measures four dimensions of fatigue: Fatigue severity, concentration problems, reduced motivation and activity. On the fatigue severity subscale, a cut-off score of 35 is used. This study 1) investigated the psychometric qualities of the CIS; 2) validated the cut-off score for severe fatigue and 3) provided norms. METHODS: Representatives of the Dutch general population (n=2288) completed the CIS. The factor structure was investigated using an exploratory factor analysis...
July 2017: Journal of Psychosomatic Research
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