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https://www.readbyqxmd.com/read/29142132/identification-of-a-small-molecule-that-compromises-the-structural-integrity-of-viroplasms-and-rotavirus-double-layered-particles
#1
Catherine Eichwald, Giuditta De Lorenzo, Elisabeth M Schraner, Guido Papa, Michela Bollati, Paolo Swuec, Matteo de Rosa, Mario Milani, Eloise Mastrangelo, Mathias Ackermann, Oscar R Burrone, Francesca Arnoldi
Despite the availability of two attenuated vaccines, rotavirus (RV) gastroenteritis remains an important cause of mortality among children in developing countries causing about 215,000 infant deaths annually. Currently, there are no specific antiviral therapies available. RV is a non-enveloped virus with a segmented double-stranded RNA genome. Viral genome replication and assembly of transcriptionally active double-layered particles (DLPs) take place in cytoplasmic viral structures called viroplasms. In this study, we describe strong impairment of the early stages of RV replication induced by a small molecule known as RNA polymerase III inhibitor, ML-60218 (ML)...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29128962/good-response-to-tolvaptan-shortens-hospitalization-in-patients-with-congestive-heart-failure
#2
Tomohito Kogure, Kentaro Jujo, Kazuyuki Hamada, Katsumi Saito, Nobuhisa Hagiwara
Tolvaptan has been gradually spread to use as a potent diuretic for congestive heart failure in the limited country. However, the response to this aquaretic drug still is unpredictable. A total of 92 patients urgently hospitalized due to congestive heart failure and treated with tolvaptan in addition to standard treatment was retrospectively analyzed. Responder of tolvaptan treatment was defined as a patient with peak negative fluid balance greater than 500 mL/day, and clinical profiles were compared between 76 responders and 16 non-responders...
November 11, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29119757/-excess-deaths-for-haematological-tumours-in-falconara-marittima-marche-region-central-italy-short-story-from-the-epidemiological-survey-up-to-now
#3
Francesca Di Salvo, Paolo Baili, Mauro Mariottini, Marco Baldini, Andrea Micheli, Elisabetta Meneghini
API is a company refining petroleum products located in Falconara Marittima (Ancona Province, Marche Region, Central Italy). Thanks to the pressure made by citizens' committees, which considered the plant as a risk source for the population residing in the surroundings municipalities, Marche Region as institution asked for an epidemiological survey. This survey found a significative excess in deaths for haematological tumours in women and in a sub-group of retired and elderly. The results were published in one report and two scientific journals, and were also presented during a public meeting...
September 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29114334/anesthesia-and-analgesia-in-the-patient-with-an-unstable-shoulder
#4
Ismael Acevedo Bambaren, Fernando Dominguez, Maria Elena Elias Martin, Silvia Domínguez
Introduction: The patient with an unstable shoulder represents a challenge for the anesthesiologist. Most patients will be young individuals in good health but both shoulder dislocation reduction, a procedure that is usually performed under specific analgesia in an urgent setting, and instability surgery anesthesia and postoperative management present certain peculiarities. Material and Methods: For the purpose of the article, 78 references including clinical trials and reviews were included...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29110699/extensively-drug-resistant-tuberculosis-in-mali-a-case-report
#5
Bassirou Diarra, Yacouba Toloba, Bakary Konate, Moumine Sanogo, Antieme Combo Georges Togo, Fatimata Camara, Gaoussou Berthe, Dianguina Soumaré, Bocar Baya, Drissa Goita, Yeya Dit Sadio Sarro, Mamoudou Maiga, Michael Belson, Susan Orsega, Sounkalo Dao, Robert L Murphy, Sophia Siddiqui, Bouke C de Jong, Seydou Doumbia, Souleymane Diallo
BACKGROUND: Drug resistant tuberculosis presents a major public health challenge. CASE PRESENTATION: We present here the first two patients diagnosed with extensively drug resistant tuberculosis in Bamako, Mali. Genotypic findings suggest possible nosocomial transmission from the first patient to the second one, resulting in superinfection of the second patient. After being diagnosed with extensively drug resistant tuberculosis in August 2016, the patients only started receiving appropriate treatment 10 months later...
November 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29108009/zika-virus-displacement-by-a-chikungunya-outbreak-in-recife-brazil
#6
Tereza Magalhaes, Cynthia Braga, Marli T Cordeiro, Andre L S Oliveira, Priscila M S Castanha, Ana Paula R Maciel, Nathalia M L Amancio, Pollyanne N Gouveia, Valter J Peixoto-da-Silva, Thaciana F L Peixoto, Helena Britto, Priscilla V Lima, Andreza R S Lima, Kerstin D Rosenberger, Thomas Jaenisch, Ernesto T A Marques
BACKGROUND: Several arboviruses, including dengue virus (DENV), Zika virus (ZIKV) and chikungunya virus (CHIKV), transmitted by Aedes mosquitoes, circulate in northeast Brazil. Diseases caused by these viruses are of great public health relevance, however, their epidemiological features in areas where the three viruses co-circulate are scarce. Here, we present analyses of molecular and serological diagnostics in a prospective study of acute febrile patients recruited from May 2015 to May 2016 in Recife, Brazil...
November 6, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29091034/updating-the-diabetic-foot-treatment-algorithm-recommendations-on-treatment-using-advanced-medicine-and-therapies
#7
Peter Blume, Stephanie Wu
OBJECTIVE: Since the last diabetic foot ulcer (DFU) treatment algorithm was published in 2002, new options for diagnostic testing and treatments have been developed. This study seeks to update the DFU treatment algorithm to include new options available in diagnostic testing and treatment. MATERIALS AND METHODS: A computerized literature search of peer-reviewed articles published between January 2003 and January 2016 was conducted using MEDLINE (PubMed), EMBASE, and the Cochrane Library...
October 20, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29071250/defining-disease-modifying-therapy-for-alzheimer-s-disease
#8
J Cummings, N Fox
BACKGROUND: Disease-modifying therapies (DMTs) are urgently needed to treat the growing number of individuals with Alzheimer's disease (AD) or at immanent risk for AD. A definition of DMT is required to facilitate the process of DMT drug development. PROCESS: This is a review of the state of the science with regard to definition and development of DMTs. RESULTS: A DMT is as an intervention that produces an enduring change in the clinical progression of AD by interfering in the underlying pathophysiological mechanisms of the disease process that lead to cell death...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29065404/urgent-start-peritoneal-dialysis-the-first-year-of-brazilian-experience
#9
Dayana Bitencourt Dias, Marcela Lara Mendes, Vanessa Burgugi Banin, Pasqual Barretti, Daniela Ponce
BACKGROUND: This study aimed to evaluate mechanical and infectious complications associated with urgent-start peritoneal dialysis (PD) and patients and technique survival in the first 180 days. METHODS: It was a prospective study that evaluated chronic patients who started unplanned PD using high-volume PD (HVPD) right after (<72 h) PD catheter placement. After hospital discharge, patients were treated with intermittent PD on alternate days in a dialysis unit until family training was provided...
October 25, 2017: Blood Purification
https://www.readbyqxmd.com/read/29065037/early-surgery-confers-one-year-mortality-benefit-in-hip-fracture-patients
#10
Kamal Maheshwari, Jeffrey Planchard, Jing You, Wael Ali Sakr, Jaiben George, Carlos Higuera-Rueda, Leif Saager, Alparslan Turan, Andrea Kurz
BACKGROUND: To evaluate the relationship between surgical timing and one-year mortality in patients requiring hip fracture repair. METHODS: We analyzed all 720 patients (> 65 years) who had hip fracture surgery between March 2005, and February 2015, identifying patients by ICD-9 diagnosis and procedure codes using electronic data query. Mortality data was obtained from the institutional database, state and Social Security Death Indices. The relationship between surgical timing (defined as the interval from admission to the start of surgery) and one-year mortality was assessed using a multivariable logistic regression, adjusting for baseline clinical status and surgical factors...
October 14, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29064801/early-enteral-nutrition-as-a-part-of-intencive-care-of-abdominal-surgical-pathology
#11
Dmytro Shkurupii
INTRODUCTION: Patients with abdominal surgical pathology always have gastrointestinal failure. Under such conditions, the enteral administration of nutrients may be started by trophic nutrition; however, starting nutritional mixtures for it have not been clearly defined. The aim of this study was optimization of energetic and plastic supply of patients with abdominal surgical pathology by studying the efficacy of the clinical nutrition means. MATERIALS AND METHODS: An observational analytical observational prospective case-control study of clinical nutrition efficacy has been conducted in 112 patients aged 18 to 45, who underwent intencive care after urgent abdominal surgical interventions...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29064025/analysis-of-first-year-twitter-metrics-of-a-rare-disease-community-for-blastic-plasmacytoid-dendritic-cell-neoplasm-bpdcn-on-social-media-bpdcn
#12
REVIEW
Naveen Pemmaraju, Audun Utengen, Vikas Gupta, Michael A Thompson, Andrew A Lane
PURPOSE OF REVIEW: The use of Twitter, one of the most commonly engaged social media platforms in the world, is increasing among the general public. Notably, this trend has also been observed among those involved in the healthcare field. With its ability to readily connect diverse groups of stakeholders in a given area of interest, Twitter has become a focal point for those involved in increasing awareness and information exchange in orphan disease fields. Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematologic malignancy with generally poor long-term outcomes for adult patients and no standard therapeutic guidelines...
October 24, 2017: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29061336/management-of-mdr-tb-in-hiv-co-infected-patients-in-eastern-europe-results-from-the-tb-hiv-study
#13
A M W Efsen, A Schultze, R F Miller, A Panteleev, A Skrahin, D N Podlekareva, J M Miro, E Girardi, H Furrer, M H Losso, J Toibaro, J A Caylà, A Mocroft, J D Lundgren, F A Post, O Kirk
OBJECTIVES: Mortality among HIV patients with tuberculosis (TB) remains high in Eastern Europe (EE), but details of TB and HIV management remain scarce. METHODS: In this prospective study, we describe the TB treatment regimens of patients with multi-drug resistant (MDR) TB and use of antiretroviral therapy (ART). RESULTS: A total of 105 HIV-positive patients had MDR-TB (including 33 with extensive drug resistance) and 130 pan-susceptible TB...
October 20, 2017: Journal of Infection
https://www.readbyqxmd.com/read/29057123/four-factor-prothrombin-complex-concentrate-reduces-time-to-procedure-in-vitamin-k-antagonist-treated-patients-experiencing-gastrointestinal-bleeding-a-post-hoc-analysis-of-two-randomized-controlled-trials
#14
Majed A Refaai, Truptesh H Kothari, Shana Straub, Jacob Falcon, Ravi Sarode, Joshua N Goldstein, Andres Brainsky, Laurel Omert, Martin L Lee, Truman J Milling
INTRODUCTION: To investigate the impact of a 4-factor prothrombin complex concentrate (4F-PCC [Beriplex®/Kcentra®]) versus plasma on "time to procedure" in patients with acute/severe gastrointestinal bleeding requiring rapid vitamin K antagonist (VKA) reversal prior to invasive procedure. METHODS: A post hoc analysis of two phase III trials of 4F-PCC versus plasma in patients with acute/severe gastrointestinal bleeding. The treatment arms were compared for study treatment volume, infusion times, and time from start of study treatment to procedure...
2017: Emergency Medicine International
https://www.readbyqxmd.com/read/29054956/indirect-carotid-cavernous-fistula-mimicking-ocular-myasthenia
#15
Lakshmi Leishangthem, Sudhakar Reddy Satti
71-year-old woman with progressive left-sided, monocular diplopia and ptosis. Her symptoms mimicked ocular myasthenia, but she had an indirect carotid cavernous fistula (CCF). She was diagnosed with monocular myasthenia gravis (negative acetylcholinesterase antibody) after a positive ice test and started on Mestinon and underwent a thymectomy complicated by a brachial plexus injury. Months later, she developed left-sided proptosis and ocular bruit. She was urgently referred to neuro-interventional surgery and was diagnosed with an indirect high-flow left CCF, which was treated with Onyx liquid and platinum coil embolisation...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054907/secondary-aortoduodenal-fistula-and-the-unrecognised-herald-bleed
#16
Francesc Simó Alari, Esther Molina González, Israel Gutierrez, Aïcha Ahamdanech-Idrissi
A 65-year-old man with history of aortobifemoral surgery 4 years ago was admitted to hospital after sudden abdominal pain. Initially misdiagnosed as renal colic, he was treated with analgesics, and while on observation he started with haematemesis, rapidly responding to volume infusion. Upper gastrointestinal endoscopy showed fresh blood in the stomach with no visible active bleeding. CT scan showed an important contrast extravasation from the aorta to the third duodenal portion, restarting haemodynamic instability and a cardiac arrest...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054530/a-molecular-morphometric-approach-to-diabetic%C3%A2-kidney-disease-can-link-structure-to%C3%A2-function-and-outcome
#17
Viji Nair, Claudiu V Komorowsky, E Jennifer Weil, Berne Yee, Jeffrey Hodgin, Jennifer L Harder, Bradley Godfrey, Wenjun Ju, Carine M Boustany-Kari, Margrit Schwarz, Kevin V Lemley, Peter J Nelson, Robert G Nelson, Matthias Kretzler
Diabetic kidney disease is the leading cause of kidney failure. However, studies of molecular mechanisms of early kidney damage are lacking. Here we examined for possible linkage between transcriptional regulation and quantitative structural damage in early diabetic kidney disease in Pima Indians with type 2 diabetes. Tissue obtained from protocol kidney biopsies underwent genome-wide compartment-specific gene expression profiling and quantitative morphometric analysis. The ultrastructural lesion most strongly associated with transcriptional regulation was cortical interstitial fractional volume (VvInt), an index of tubule-interstitial damage...
October 18, 2017: Kidney International
https://www.readbyqxmd.com/read/29035618/impact-of-intensity-modulated-radiotherapy-on-health-care-costs-of-patients-with-anal-squamous-cell-carcinoma
#18
Alexander L Chin, Erqi L Pollom, Yushen Qian, Albert C Koong, Daniel T Chang
PURPOSE: Drivers of variation in the cost of care after chemoradiotherapy for the management of anal squamous cell carcinoma (SCC) have not been fully elucidated. We sought to characterize the direct and indirect impact of radiotherapy modality on health care costs among patients with anal SCC. PATIENTS AND METHODS: A retrospective cohort study was performed using the 2014 linkage of the SEER-Medicare database. We identified 1,025 patients with anal SCC diagnosed between 2001 and 2011 and treated with chemoradiotherapy...
October 16, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29022223/acute-kidney-injury-in-pregnancy-and-the-role-of-underlying-ckd-a-point-of-view-from-m%C3%A3-xico
#19
REVIEW
Margarita Ibarra-Hernández, Oralia Alejandra Orozco-Guillén, María Luz de la Alcantar-Vallín, Ruben Garrido-Roldan, María Patricia Jiménez-Alvarado, Kenia Benitez Castro, Francisco Villa-Villagrana, Mario Borbolla, Juan Manuel Gallardo-Gaona, Guillermo García-García, Norberto Reyes-Paredes, Giorgina Barbara Piccoli
The incidence of acute kidney injury in pregnancy (P-AKI) in developed countries is significantly lower than in developing ones, where it is estimated to range between 4 and 26%. Mortality in cases of P-AKI requiring dialysis is high, varying from 20 to 80%. In developing countries, clinical decisions are often based on the availability of services and not on needs. Prenatal surveillance in Mexico does not include serum creatinine, limiting the potential for early diagnosis of AKI and CKD and their differential diagnosis...
October 11, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/29021896/disease-modification-and-neuroprotection-in-neurodegenerative-disorders
#20
REVIEW
Jeffrey Cummings
BACKGROUND: Disease modifying therapies (DMTs) are urgently needed for neurodegenerative diseases (NDD) such as Alzheimer's disease (AD) and many other disorders characterized by protein aggregation and neurodegeneration. Despite advances in understanding the neurobiology of NDD, there are no approved DMTs. DISCUSSION: Defining disease-modification is critical to drug-development programs. A DMT is an intervention that produces an enduring change in the trajectory of clinical decline of an NDD by impacting the disease processes leading to nerve cell death...
2017: Translational Neurodegeneration
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