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https://www.readbyqxmd.com/read/29777574/factors-influencing-the-umbilical-cord-blood-stem-cell-industry-an-evolving-treatment-landscape
#1
REVIEW
Carla Dessels, Marco Alessandrini, Michael Sean Pepper
Hematopoietic stem cell transplantation (HSCT) is common practice today for life threatening malignant and non-malignant diseases of the blood and immune systems. Umbilical cord blood (UCB) is rich in hematopoietic stem cells (HSCs) and is an attractive alternative to harvesting HSCs from bone marrow or when mobilized into peripheral blood. One of the most appealing attributes of UCB is that it can be banked for future use and hence provides an off-the-shelf solution for patients in urgent need of a transplantation...
May 18, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29772262/an-international-survey-of-cleaning-and-disinfection-practices-in-the-healthcare-environment
#2
Nikki Kenters, Thomas Gottlieb, Joost Hopman, Shaheen Mehtar, Marin L Schweizer, Ermira Tartari, E G W Huijskens, Andreas Voss
BACKGROUND: Antimicrobial resistance has become an urgent global health priority. Basic hygiene practices and cleaning and disinfection of the hospital environment are key in preventing pathogen cross-transmission. AIM: To our knowledge no studies have assessed the worldwide differences in cleaning and disinfection practices in healthcare facilities. The electronic survey described here was developed in order to evaluate differences in healthcare facility cleaning practices around the world...
May 14, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29764528/symptomatic-myocardial-bridging-a-frequently-occurring-coronary-variation-can-cause-severe-myocardial-ischaemia-in-affected-children-with-underlying-cardiac-conditions
#3
Alexandra Kiess, Marcel Vollroth, Farhad Bakhtiary, Hiroshi Seki, Martin Kostelka, Milan Djukic, Ingo Daehnert, Robert Wagner
Myocardial bridging is a congenital coronary artery anomaly in which the coronary artery has a partly "tunnelled" intramyocardial course. This tunnelling leads to compression of the affected vessel segment during ventricular systole. It is considered to be a benign variation of the norm in about 25% of the population caused by an aberrancy of embryologic coronary development. The bridging is also thought to cause severe cardiac conditions in a few of those affected. The series of six young patients presented here is the largest series so far to report on symptomatic myocardial bridging in children with different underlying heart diseases...
May 16, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29757995/a-personalized-qos-prediction-approach-for-cps-service-recommendation-based-on-reputation-and-location-aware-collaborative-filtering
#4
Li Kuang, Long Yu, Lan Huang, Yin Wang, Pengju Ma, Chuanbin Li, Yujia Zhu
With the rapid development of cyber-physical systems (CPS), building cyber-physical systems with high quality of service (QoS) has become an urgent requirement in both academia and industry. During the procedure of building Cyber-physical systems, it has been found that a large number of functionally equivalent services exist, so it becomes an urgent task to recommend suitable services from the large number of services available in CPS. However, since it is time-consuming, and even impractical, for a single user to invoke all of the services in CPS to experience their QoS, a robust QoS prediction method is needed to predict unknown QoS values...
May 14, 2018: Sensors
https://www.readbyqxmd.com/read/29751512/screening-of-natural-product-derivatives-identifies-two-structurally-related-flavonoids-as-potent-quorum-sensing-inhibitors-against-gram-negative-bacteria
#5
Suvi Manner, Adyary Fallarero
Owing to the failure of conventional antibiotics in biofilm control, alternative approaches are urgently needed. Inhibition of quorum sensing (QS) represents an attractive target since it is involved in several processes essential for biofilm formation. In this study, a compound library of natural product derivatives ( n = 3040) was screened for anti-quorum sensing activity using Chromobacterium violaceum as reporter bacteria. Screening assays, based on QS-mediated violacein production and viability, were performed in parallel to identify non-bactericidal QS inhibitors (QSIs)...
May 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29741481/urgent-balloon-aortic-valvuloplasty-in-patients-with-cardiogenic-shock-related-to-severe-aortic-stenosis-time-matters
#6
Nicolas Debry, Patrick Kone, Flavien Vincent, Gilles Lemesle, Cédric Delhaye, Guillaume Schurtz, Hugues Spillemaeker, Sina Porouchani, Augustin Coisne, Jean-Luc Auffray, Arnaud Sudre, Nicolas Lamblin, Laurent Bonello, Eric Van Belle
AIMS: To assess outcomes of balloon aortic valvuloplasty (BAV) as a rescue therapy in patients with cardiogenic shock (CS) related to severe aortic stenosis (AS). METHODS AND RESULTS: Forty-four consecutive patients, n=31 with hypotensive-CS (HCS) and n=13 with non-hypotensive CS (NHCS) due to acutely decompensated severe AS, from two centres were treated with emergency BAV. Composite primary endpoint was mortality or recurrent CS at 1-year follow-up. These patients (77...
May 8, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29737253/febrile-neutropenia-in-children-with-cancer-approach-to-diagnosis-and-treatment
#7
Rejin Kebudi, Hande Kizilocak
Febrile neutropenia is one of the major acute side effects of intensive treatment in pediatric cancer, necessitating prompt initiation of empirical broad-spectrum antibiotics. Patients may be classified as low or high risk according some risk factors (duration of neutropenia, depth of neutropenia, type of cancer, state of disease, bone marrow involvement, type of treatment, additional health problems). Initial evaluation of the febrile neutropenic child should include the history of the child, a detailed physical examination, blood culture (peripheral and catheter), urinalysis and culture, cultures of lesions...
May 8, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29718656/small-molecule-inhibitors-of-metabolic-enzymes-repurposed-as-a-new-class-of-anthelmintics
#8
Rahul Tyagi, Amarendar Reddy Maddirala, Mostafa Elfawal, Chelsea Fischer, Christina Bulman, Bruce A Rosa, Xin Gao, Ryan Chugani, Mingzhou Zhou, Jon Helander, Paul Brindley, Chih-Chung Tseng, Iain R Greig, Judy Sakanari, Scott A Wildman, Raffi Aroian, James W Janetka, Makedonka Mitreva
The enormous prevalence of infections caused by parasitic nematodes worldwide, coupled to the rapid emergence of their resistance to commonly used anthelmintic drugs, presents an urgent need for the discovery of new drugs. Herein, we have identified several classes of small molecules with broad spectrum activity against these pathogens. Previously, we reported the identification of carnitine palmitoyltransferases (CPTs) as a representative class of enzymes as potential targets for metabolic chokepoint intervention that was elucidated from a combination of chemogenomic screening and experimental testing in nematodes...
May 2, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29716576/protocol-a-multi-level-intervention-program-to-reduce-stress-in-9-1-1-telecommunicators
#9
Hendrika Meischke, Michelle Lilly, Randal Beaton, Rebecca Calhoun, Ann Tu, Scott Stangenes, Ian Painter, Debra Revere, Janet Baseman
BACKGROUND: Nationwide, emergency response systems depend on 9-1-1 telecommunicators to prioritize, triage, and dispatch assistance to those in distress. 9-1-1 call center telecommunicators (TCs) are challenged by acute and chronic workplace stressors: tense interactions with citizen callers in crisis; overtime; shift-work; ever-changing technologies; and negative work culture, including co-worker conflict. This workforce is also subject to routine exposures to secondary traumatization while handling calls involving emergency situations and while making time urgent, high stake decisions over the phone...
May 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29712789/macrophage-depletion-ameliorates-peripheral-neuropathy-in-aging-mice
#10
Xidi Yuan, Dennis Klein, Susanne Kerscher, Brian L West, Joachim Weis, Istvan Katona, Rudolf Martini
Aging is known as a major risk factor for the structure and function of the nervous system. There is urgent need to overcome such deleterious effects of age-related neurodegeneration. Here we show that peripheral nerves of 24-month-old aging C57Bl6 mice of either sex show similar pathological alterations as nerves from aging human individuals while 12 months old adult mice lack such alterations. Specifically, nerve fibers showed de- and remyelination and axonal lesion. Moreover, in the aging mice, neuromuscular junctions showed features typical for dying-back neuropathies, as revealed by a decline of pre-synaptic markers, associated with α-bungarotoxin-positive postsynapses...
April 30, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29710164/effect-of-ticagrelor-plus-aspirin-ticagrelor-alone-or-aspirin-alone-on-saphenous-vein-graft-patency-1-year-after-coronary-artery-bypass-grafting-a-randomized-clinical-trial
#11
RANDOMIZED CONTROLLED TRIAL
Qiang Zhao, Yunpeng Zhu, Zhiyun Xu, Zhaoyun Cheng, Ju Mei, Xin Chen, Xiaowei Wang
Importance: The effect of ticagrelor with or without aspirin on saphenous vein graft patency in patients undergoing coronary artery bypass grafting (CABG) is unknown. Objective: To compare the effect of ticagrelor + aspirin or ticagrelor alone vs aspirin alone on saphenous vein graft patency 1 year after CABG. Design, Setting, and Participants: Randomized, multicenter, open-label, clinical trial among 6 tertiary hospitals in China. Eligible patients were aged 18 to 80 years with indications for elective CABG...
April 24, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29701381/abdominal-aortic-aneurysm-in-women-retrospective-analysis-of-the-cases-that-undergo-surgical-repair
#12
Bárbara Pereira, André Marinho, Roger Rodrigues, Mário Moreira, Mafalda Correia, Pedro Lima, Joana Silva, João Alegrio, Óscar Gonçalves
INTRODUCTION: The prevalence of infra-renal aortic abdominal aneurysms (AAA) is about 3 to 4 times higher in men, with a recommendation I 1a for screening men > 65y. Althoug women only represente 20% of the total AAAs they have a significant higher rupture rate - threefold higher - and a worse outcome after ruptured AAA repair. Screening is not consensual but can be recommended for women > 65y who have smoked or have a family history of AAA. Against screening is the fact that the AAA in women have not only a lower incidence but also a late presentation (>80y) but references have been made to the fact that smoking became popular more than 30 years after than men and so the effects just now can start to be seen...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29698504/addressing-the-most-neglected-diseases-through-an-open-research-model-the-discovery-of-fenarimols-as-novel-drug-candidates-for-eumycetoma
#13
Wilson Lim, Youri Melse, Mickey Konings, Hung Phat Duong, Kimberly Eadie, Benoît Laleu, Ben Perry, Matthew H Todd, Jean-Robert Ioset, Wendy W J van de Sande
Eumycetoma is a chronic infectious disease characterized by a large subcutaneous mass, often caused by the fungus Madurella mycetomatis. A combination of surgery and prolonged medication is needed to treat this infection with a success rate of only 30%. There is, therefore, an urgent need to find more effective drugs for the treatment of this disease. In this study, we screened 800 diverse drug-like molecules and identified 215 molecules that were active in vitro. Minimal inhibitory concentrations were determined for the 13 most active compounds...
April 26, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29687879/time-to-treatment-is-an-independent-prognostic-factor-in-aggressive-non-hodgkin-lymphomas
#14
Adam J Olszewski, Thomas Ollila, John L Reagan
In aggressive lymphomas, discrepancies in survival reported from experimental and observational studies may reflect selective non-enrolment of high-risk patients in trials. We examined the association between time from diagnosis to chemotherapy and overall survival in diffuse large B-cell (DLBCL), Burkitt (BL), mantle cell (MCL) and peripheral T-cell lymphoma (PTCL), using National Cancer Data Base records of 130 549 patients treated in 2004-2014. Across the histologies, patients who started chemotherapy within 7 days of diagnosis had more often high International Prognostic Index (IPI) or advanced-stage disease...
April 24, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29685874/impact-of-oral-side-effects-from-conditioning-therapy-before-hematopoietic-stem-cell-transplantation-protocol-for-a-multicenter-study
#15
Michael T Brennan, Bengt Hasséus, Allan J Hovan, Judith E Raber-Durlacher, Nicole Ma Blijlevens, Marie-Charlotte Huysmans, Karin Garming Legert, Jan-Erik Johansson, Charity G Moore, Inger von Bültzingslöwen
BACKGROUND: The oral cavity is a common site of complications related to the cytotoxic effect of high-dose chemotherapy and radiation therapy. Considering our limited understanding of the burden of illness in the oral cavity from various cytotoxic therapies, it is difficult to produce evidence-based, preventive and management protocols. A prospective multicenter study is necessary to collect data on the burden of illness from various cytotoxic regimens. OBJECTIVE: The objectives of this prospective international observational multicenter study in hematopoietic stem cell transplant (HSCT) patients are to establish the nature, incidence and temporal relationship of oral complications related to conditioning regimens (chemotherapy with or without total body irradiation), stem cell transplantation and the immunologic reactions (mainly graft-vs-host-disease) that may follow, and to determine what subjective and objective oral complications related to treatment can predict negative clinical and economic outcomes and reduced quality of life...
April 23, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29676183/synthesis-%C3%AE-glucosidase-inhibitory-glucose-consumption-promoting-activities-of-flavonoid-coumarin-hybrids
#16
Hua Sun, Xiaotong Song, Yunchang Tao, Ming Li, Ke Yang, Hang Zheng, Zongxin Jin, Robert H Dodd, Guojun Pan, Kui Lu, Peng Yu
AIM: The research of novel and potent antidiabetic agents is urgently needed for the control of the exploding diabetic population. We previously reported the synthesis and antidiabetic activity of natural 8-(6"-umbelliferyl)-apigenin (1), but its antidiabetic targets are not known. Therefore, four series of derivatives were synthesized and evaluated for their antidiabetic activities. Results & methodology: Compounds (5a) and (14a) were identified as new α-glucosidase and α-amylase dual inhibitors...
April 20, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29676003/does-peritoneal-dialysis-have-a-role-in-urgent-start-end-stage-kidney-disease
#17
Rory F McQuillan, Charmaine E Lok
Despite its many positive attributes, peritoneal dialysis remains underutilized, particularly in the United States. Urgent-start peritoneal dialysis (PD) has been proposed as a method of increasing PD prevalence. Urgent-start PD has been shown to be safe, feasible, and effective. However, urgent-start PD is also accompanied by several multidimensional challenges. This article is intended to equip the reader with a practical sense of whether an urgent-start PD program would be appropriate in his or her own clinical context and if appropriate, what factors would be necessary for such a program to flourish...
April 19, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29672319/the-use-of-low-calcium-hemodialysis-in-the-treatment-of-hypercalcemic-crisis
#18
Sinan Trabulus, Meric Oruc, Emre Ozgun, Mehmet Riza Altiparmak, Nurhan Seyahi
BACKGROUND: We reviewed the results of low-calcium hemodialysis (LCHD; 1.25 mmol/L) in the treatment of 42 cases admitting with hypercalcemic crisis. METHODS: All patients (≥18 years) who started LCHD due to hypercalcemia between 2002 and 2017 were retrospectively analyzed. Biochemical data were obtained at the beginning of the first hemodialysis and at the end of the last hemodialysis. -"Refractory" cases were defined as patients having albumin corrected serum total calcium (SCatotal) levels above 10...
April 19, 2018: Nephron
https://www.readbyqxmd.com/read/29671379/enhanced-degradation-of-perfluorooctanoic-acid-by-a-genome-shuffling-modified-pseudomonas-parafulva-yab-1
#19
Langbo Yi, Qingzhong Peng, Deming Liu, Lulu Zhou, Chongjian Tang, Yaoyu Zhou, Liyuan Chai
Perfluorooctanoic acid (PFOA) as an emerging persistent organic pollutant is hard to be degraded by conventional methods because of its stable physical and chemical properties. Microbial transformation is an attractive remediation approach to prevent and clean up PFOA contamination. To date, several strains of wild microbes have been reported to have limited capacity to degrade PFOA, Selection of superior strains degrading PFOA become urgently necessary. Here, we report the application of genome shuffling to improve the PFOA-degrading bacterium Pseudomonas Parafulva YAB-1...
April 19, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29668597/hiv-syphilis-and-behavioral-risk-factors-among-men-who-have-sex-with-men-in-a-drug-using-area-of-southwestern-china-results-of-3-cross-sectional-surveys-from-2013-to-2015
#20
Lan Guanghua, Chen Yi, Tang Shuai, Shen Zhiyong, Tang Zhenzhu, Ruan Yuhua, Mohammed Adnan Yousuf, Fan Wensheng
To assess human immunodeficiency virus (HIV), syphilis, and behavioral risk factors among men who have sex with men (MSM) in southwestern China, where HIV started as a drug-driven epidemic, and shifted to mainly heterosexual transmission.These cross-sectional studies were conducted yearly in 2013, 2014, and 2015 in Guangxi, China. A total of 1,996, 1,965, and 1,697 participants were recruited in 2013, 2014, and 2015, respectively. The data included demographic and sexual behavioral variables. Other variables included individuals who used illegal drugs, and who received HIV counseling, testing, and free condoms, and peer education...
April 2018: Medicine (Baltimore)
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