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hyperuricemia and lipid parameters

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https://www.readbyqxmd.com/read/27124606/curcumin-lowers-serum-lipids-and-uric-acid-in-subjects-with-nonalcoholic-fatty-liver-disease-a-randomized-controlled-trial
#1
Yunes Panahi, Parisa Kianpour, Reza Mohtashami, Ramezan Jafari, Luis E Simental-Mendía, Amirhossein Sahebkar
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is one of the most common hepatic diseases in the general adult population. Dyslipidemia, hyperuricemia, and insulin resistance are common risk factors and accompanying features of NAFLD. Curcumin is a dietary natural product with beneficial metabolic effects relevant to the treatment of NAFLD. AIM: To assess the effects of curcumin on metabolic profile in subjects with NAFLD. METHODS: Patients diagnosed with NAFLD (grades 1-3; according to liver sonography) were randomly assigned to curcumin (1000 mg/d in 2 divided doses) (n = 50) or control (n = 52) group for a period of 8 weeks...
September 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/26545544/nutritional-intake-and-nutritional-status-in-elite-mexican-teenagers-soccer-players-of-different-ages
#2
Roberto Hidalgo y Teran Elizondo, Francisco Manuel Martín Bermudo, Ricardo Peñaloza Mendez, Genoveva Berná Amorós, Eleazar Lara Padilla, Francisco José Berral de la Rosa
INTRODUCTION: nutritional intake and status of soccer players has attracted not much research attention. Many soccer players follow an inadequate nutritional intake and have a poor nutritional status. This is relevant in youngsters soccer players, in order to improve performance and promote healthy dietary practices. AIMS: analyze anthropometric characterizes, evaluate nutritional intake and status, dietary habits and pre- and post-exercise meals in elite teenagers soccer players...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/26316538/psoriasis-as-an-independent-risk-factor-for-cardiovascular-disease-an-epidemiologic-analysis-using-a-national-database
#3
Yi Chun Lai, Yik Weng Yew
BACKGROUND: Psoriasis is known to be associated with metabolic syndrome, a well-established risk factor for ischemic heart disease and stroke. Emerging evidence indicates that psoriasis is an independent risk factor for cardiovascular disease and stroke. OBJECTIVE: To evaluate whether psoriasis is independently associated with myocardial infarction (MI), ischemic heart disease (MI, angina pectoris, or coronary heart disease), and stroke, we conducted a cross-sectional study using the US National Health and Nutrition Examination Survey (NHANES) database...
July 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/26211248/-research-on-hemorheology-in-rats-with-acute-hyperuricemia
#4
Kuihua Li, Xifu Wang, Yuling Liu, Lu Li, Shiq Xu, Xiaobo Tong, Lide Xie, Weijuan Yao
Hyperuricemia is a risk factor for various diseases, but knowledge on acute hyperuricemia is still not sufficient. The present study was aimed to investigate the effect of acute hyperuricemia on red blood cells from hemorheological point of view, and to provide the reference for clinical treatment. The rats were gavaged with 500 mg/kg hypoxanthine and intraperitoneally injected with 100 mg/kg oxonate to induce the model of acute hyperuricemia. The same volume of blood samples were drawn within time period of 0, 1, 2, 3 and 6 h, respectively, from the inner canthus of rats to measure the serum uric acid, hemorheological parameters and the malondialdehyde level...
April 2015: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/26178150/impact-of-irbesartan-an-angiotensin-receptor-blocker-on-uric-acid-level-and-oxidative-stress-in-high-risk-hypertension-patients
#5
Ryuji Chida, Itaru Hisauchi, Shigeru Toyoda, Migaku Kikuchi, Takaaki Komatsu, Yuichi Hori, Shiro Nakahara, Yoshihiko Sakai, Teruo Inoue, Isao Taguchi
Hyperuricemia is a known cardiovascular risk factor. The angiotensin II receptor blocker (ARB) losartan is known to decrease serum uric acid (UA) level. A recent in vitro study demonstrated a strong interaction between irbesartan and UA transporters that exceeded that of losartan. The purpose of the present study was to evaluate the hypouricemic effect of irbesartan in a clinical setting. A total of 40 high-risk hypertensive outpatients with coronary artery disease, cerebrovascular disease and/or diabetes complications who were taking ARBs other than irbesartan and losartan were enrolled in this study...
November 2015: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/25894164/effects-of-hyperuricemia-on-renal-function-in-pediatric-renal-transplant-recipients
#6
Cihan Fidan, Aslı Kantar, Esra Baskın, Kaan Gülleroğlu, Aydıncan Akdur, Gökhan Moray, Mehmet Haberal
OBJECTIVES: Hyperuricemia is common in pediatric renal transplant recipients, and it is associated with poor allograft outcomes. Hyperuricemia occurs early after transplant and is associated with use of diuretics, cyclosporine therapy, a history of hyperuricemia, and decreased glomerular filtration rate. We aimed to investigate causes and effects of hyperuricemia on allograft outcomes in our patients. MATERIALS AND METHODS: There were 81 pediatric transplant patients (41 female and 40 male) included in the study...
April 2015: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/25549473/-age-dependent-characteristics-of-nutritional-status-and-resting-metabolism-in-overweight-and-obese-children
#7
E V Pavlovskaia, T V Strokova, A G Surkov, A R Bogdanov, G V Borodina, E N Kutyreva, T B Sentsova
The age-dependent nutritional status and resting metabolism in overweight and obese children have been examined. The study included 625 children of 2.5-17 years old. Patients were divided into three groups: 1st--2.5-7 years old (n = 49), 2nd--8-12 years old (n = 204), 3rd--13-17 years old (n = 372). The diagnosis of overweight and obesity was based on CDC criteria: children with 85-94 BMI percentile according to age and gender had overweight, BMI 295 percentile--obesity. Anthropometry, bioelectric impedance analysis and indirect respiratory calorimetry were performed; lipid and carbohydrate parameters were measured...
2014: Voprosy Pitaniia
https://www.readbyqxmd.com/read/25261431/association-of-metabolic-syndrome-and-its-components-with-hyperuricemia-in-a-mediterranean-population
#8
Amparo Vayá, Leonor Rivera, Antonio Hernández-Mijares, Daniel Bautista, Eva Solá, Marco Romagnoli, Rafael Alis, Begoña Laiz
Several studies have found an association between hyperuricemia and metabolic syndrome (MS), although there are discrepancies as to which MS components play a pivotal role in this association. We aimed to investigate the association between serum uric acid (SUA) levels and MS in a Mediterranean population (eastern Spain). We performed a case-control study of 71 patients with MS and 122 healthy controls. MS was defined according to the revised National Cholesterol Education Program Adult Treatment Panel III modified criteria...
2015: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/25097480/madelung-s-disease-in-a-patient-with-chronic-renal-insufficiency-a-case-report-and-review-of-literature
#9
Beata Bergler-Czop, Dominika Wcisło-Dziadecka, Ligia Brzezińska-Wcisło
Madelung's disease (benign symmetric lipomatosis, Launois-Bensaude syndrome) was described for the first time in the middle of the 19(th) century. This disorder concerns mainly men between 30 and 60 years of age. Patients often suffer from coexisting ailments, such as hepatic function disorders, polyneuropathy, diabetes, gynecomastia, hyperuricemia and deviations of lipid management parameters. Treatment of benign symmetric lipomatosis consists mainly in fat tissue sucking or injection lipolysis. Patients often have to wear special clothes correcting the deformed figure...
May 2014: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/25052552/associations-of-non-high-density-lipoprotein-cholesterol-and-traditional-blood-lipid-profiles-with-hyperuricemia-among-middle-aged-and-elderly-chinese-people-a-community-based-cross-sectional-study
#10
Juan Xu, Hao Peng, Qinghua Ma, Xiaohua Zhou, Wenxin Xu, Liang Huang, Jiarong Hu, Yonghong Zhang
BACKGROUND: Increased serum uric acid (SUA) is associated with dyslipidemia. However, there are conflicting data about the role of single lipid species including non-high density lipoprotein cholesterol (non-HDL-C) in promoting SUA accumulation. Here, we aimed to compare non-HDL-C with other traditional blood lipid profiles in relation to hyperuricemia in a middle-aged and elderly Chinese population. METHODS: Data was collected from 9580 participants undergoing routine physical examinations in Xiangcheng district of Suzhou...
July 23, 2014: Lipids in Health and Disease
https://www.readbyqxmd.com/read/24944394/effects-of-fenofibrate-on-albuminuria-in-patients-with-hypertriglyceridemia-and-or-hyperuricemia-a-multicenter-randomized-double-blind-placebo-controlled-crossover-study
#11
Tsutomu Kazumi, Tsutomu Hirano, Gen Yoshino, For The Fenofibrate Study Group
BACKGROUND: A slight increase in albuminuria (urinary albumin excretion [UAE] ≥30 mg/d) is associated with hypertension, type 2 diabetes mellitus, dyslipidemia (high triglyceride [TG] and low high-density lipoprotein cholesterol [HDL-C] concentrations), and hyperuricemia. Although antihypertensive and antidiabetic therapies have been reported to reduce UAE, an association between improvement in dyslipidemia and/or hyperuricemia and a reduction in UAE has not been reported. OBJECTIVE: The aim of this study was to investigate the efficacy and tolerability of fenofibrate on albuminuria in patients with hypertriglyceridemia and/or hyperuricemia...
July 2003: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/24475021/elevated-serum-triglyceride-and-retinol-binding-protein-4-levels-associated-with-fructose-sweetened-beverages-in-adolescents
#12
Te-Fu Chan, Wei-Ting Lin, Yi-Ling Chen, Hsiao-Ling Huang, Wei-Zeng Yang, Chun-Ying Lee, Meng-Hsueh Chen, Tsu-Nai Wang, Meng-Chuan Huang, Yu-Wen Chiu, Chun-Chi Huang, Sharon Tsai, Chih-Lung Lin, Chien-Hung Lee
BACKGROUND: The metabolic effect of fructose in sugar-sweetened beverages (SSB) has been linked to de novo lipogenesis and uric acid (UA) production. OBJECTIVES: This study investigated the biological effects of SSB consumption on serum lipid profiles and retinol-binding protein 4 (RBP4) among Taiwanese adolescents. METHODS: We evaluated the anthropometric parameters and biochemical outcomes of 200 representative adolescents (98 boys and 102 girls) who were randomly selected from a large-scale cross-sectional study...
2014: PloS One
https://www.readbyqxmd.com/read/24332707/bariatric-surgery-in-severely-obese-adolescents-improves-major-comorbidities-including-hyperuricemia
#13
Andreas Oberbach, Jochen Neuhaus, Thomas Inge, Katharina Kirsch, Nadine Schlichting, Susann Blüher, Yvonne Kullnick, Joachim Kugler, Sven Baumann, Holger Till
OBJECTIVE: Serum uric acid (sUA) is believed to contribute to the pathogenesis of metabolic comorbidities like hypertension, insulin-resistance (IR) and endothelial dysfunction (EDF) in obese children. The present pilot study investigated the association between sUA concentrations and loss of body weight following laparoscopic sleeve gastrectomy (LSG) or laparoscopic Roux-en-Y-gastric bypass (RYGB) in severely obese adolescents. MATERIALS/METHODS: 10 severely obese adolescents underwent either LSG (n=5) or RYGB (n=5)...
February 2014: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/24180145/prevalence-of-hyperuricaemia-in-a-rural-population-of-nigerian-niger-delta-region
#14
C A Alikor, P C Emem-Chioma, O J Odia
INTRODUCTION: Hyperuricemia is a cardiovascular disease risk factor that has been poorly researched into in Africa and its prevalence is largely unknown in the rural areas in Nigeria and in the Niger Delta region of Nigeria in particular. METHODS: A cross-sectional rural survey involving 500 subjects aged 15 years and above. Demographic and social data were obtained using a questionnaire. Anthropometric (height, weight, waist circumference) and blood pressure measurements were taken...
July 2013: Nigerian Journal of Medicine: Journal of the National Association of Resident Doctors of Nigeria
https://www.readbyqxmd.com/read/23966810/alkalizer-administration-improves-renal-function-in-hyperuricemia-associated-with-obesity
#15
Jun Saito, Yoko Matsuzawa, Hiroko Ito, Masao Omura, Tomoshige Kino, Tetsuo Nishikawa
We evaluated the combination effect of the alkalizer citrate with the xanthine oxidase inhibitor allopurinol on renal function and uric acid in patients with hyperuricemia associated with obesity and/or metabolic syndrome (MetS), who were extracted from among the subjects enrolled in a prospective randomized controlled study aimed at assessing the efficacy of such a combination for improving renal function. We also conducted a post hoc analysis to examine influences on lipid profiles. Patients who consented to participate in the study were randomly allocated to receive either allopurinol alone (monotherapy) or in combination with a citrate preparation (combination therapy)...
2013: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/23446318/association-of-uric-acid-with-obesity-and-endothelial-dysfunction-in-children-and-early-adolescents
#16
Manabu Ishiro, Ryuzo Takaya, Yasuhiko Mori, Kimitaka Takitani, Yukako Kono, Keisuke Okasora, Toshihiko Kasahara, Hiroshi Tamai
BACKGROUND: Hyperuricemia in adults is known to be associated with hypertension, the metabolic syndrome and cardiovascular disease. The purpose of this study was to elucidate the factors associated with hyperuricemia in obese children and early adolescents and to investigate the threshold serum level of uric acid (UA) for the metabolic syndrome in children. METHODS: We assessed anthropometric measurements, blood pressure, body composition and biochemical data in 1,559 obese children...
2013: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/23312056/glycogen-storage-disease-type-ia-linkage-of-glucose-glycogen-lactic-acid-triglyceride-and-uric-acid-metabolism
#17
Sakine Sever, David A Weinstein, Joseph I Wolfsdorf, Reyhan Gedik, Ernst J Schaefer
A female presented in infancy with hypotonia, undetectable serum glucose, lactic acidosis, and triglycerides >5000 mg/dL. The diagnosis of type 1A glycogen storage disease was made via the result of a liver biopsy, which showed increased glycogen and absent glucose-6-phosphatase enzyme activity. The patient was treated with dextrose administered orally, which was replaced by frequent feedings of cornstarch, which resulted in an improvement of her metabolic parameters. At age 18 years of age, she had marked hypertriglyceridemia (3860 mg/dL) and eruptive xanthomas and was treated with fenofibrate, atorvastatin, and fish oil...
November 2012: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/23237621/gender-body-mass-index-and-ppar%C3%AE-polymorphism-are-good-indicators-in-hyperuricemia-prediction-for-han-chinese
#18
Ming-Fen Lee, Tsan-Hon Liou, Weu Wang, Wen-Harn Pan, Wei-Jei Lee, Chung-Tan Hsu, Suh-Fen Wu, Hsin-Hung Chen
Hyperuricemia is closely associated with obesity and metabolic abnormalities, which is also an independent risk factor for cardiovascular diseases. The PPARγ gene, which is linked to obesity and metabolic abnormalities in Han Chinese, might be considered a top candidate gene that is involved in hyperuricemia. This study recruited 457 participants, aged 20-40 years old, to investigate the associations of the PPARγ gene and metabolic parameters with hyperuricemia. Three tag-single nucleotide polymorphisms, rs2292101, rs4684846, and rs1822825, of the PPARγ gene were selected to explore their association with hyperuricemia...
January 2013: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/23089370/hyperuricemia-and-metabolic-syndrome-in-children-with-overweight-and-obesity
#19
Soralla Civantos Modino, M Guadalupe Guijarro de Armas, Susana Monereo Mejías, July M Montaño Martínez, Paloma Iglesias Bolaños, María Merino Viveros, Jose María Ladero Quesada
OBJECTIVE: To study the prevalence of hyperuricemia in children with overweight or obesity and analyze the relation with metabolic syndrome and the diseases that define it. MATERIALS AND METHODS: This is a cross-sectional prevalence study in 148 children recruited from pediatric endocrinology consultation, with overweight or obesity (12±3 years, 48% boys, BMI 31.8±6.1). We measured BMI, waist-height, waist circumference, blood pressure with standard instrumentation and glucose (fasting and after overload with 75 g), insulin resistance, cholesterol HDL, triglycerides and uric acid...
November 2012: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
https://www.readbyqxmd.com/read/22813565/factor-analysis-of-diabetic-nephropathy-in-chinese-patients
#20
Weiwei Zheng, Ling Chen
OBJECTIVE: To investigate factors related to albuminuria in diabetic nephropathy (DN). METHODS: Clinical data of 873 Chinese patients with type 2 diabetes were gathered retrospectively. Urinary albumin-creatinine-ratio was tested thrice for each patient before calculating its mean value for DN diagnosing and staging. Inter-relationship among variables was studied using factor analysis, and factor scores were compared and used as independent variables in regression models to identify the parameter clusters that predict the development and/or progression of DN...
July 2011: Diabetes & Metabolic Syndrome
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