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hyperuricemia and lipid parameters

Hongbo Yang, Linjie Wang, Xiaonan Qiu, Kemin Yan, Fengying Gong, Huijuan Zhu, Hui Pan
BACKGROUND: Recombinant human growth hormone (rhGH) replacement therapy is usually stopped after linear growth completion in patients with growth hormone deficiency. In patients with multiple pituitary hormone deficiency (MPHD), the long-term effects of discontinuation of rhGH replacement are unknown. METHODS: In this study, the anthropometric and metabolic parameters of 24 male patients with adult growth hormone deficiency (AGHD) due to MPHD in childhood after cessation of rhGH therapy for a mean of 7...
April 24, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Alberto Francisco Rubio-Guerra, Daniel Rabindranath Benítez-Maldonado, José Juan Lozano-Nuevo, Karla Corina Arana-Pazos, Saul Huerta-Ramirez, Jorge Luis Narváez-Rivera
INTRODUCTION AND OBJECTIVE: Epicardial fat has been associated with increased cardiovascular risk and the development of atherosclerosis. Transthoracic echocardiography provides a reliable measurement of epicardial fat thickness (EFT). The aim of this study is to evaluate the relationship between EFT and biochemical parameters of metabolic risk. MATERIAL AND METHOD: We assessed 211 patients who underwent echocardiography; EFT was measured by two cardiologists. In addition, patients' glycaemia, lipid profile and serum uric acid were measured...
February 28, 2018: Medicina Clínica
V Mojto, A Gvozdjakova, J Kucharska, Z Rausova, O Vancova, J Valuch
OBJECTIVE: The aim of the study was to observe the influence of 11-days complete water fasting (WF) and regeneration diet (RD) on renal function, body weight, blood pressure and oxidative stress. BACKGROUND: Therapeutic WF is considered a healing method. METHODS: Ten volunteers drank only water for 11 days, followed by RD for the next 11 days. Data on body weight, blood pressure, kidney functions, antioxidants, lipid peroxidation, cholesterols, triacylglycerols and selected biochemical parameters were obtained...
2018: Bratislavské Lekárske Listy
Tin Lok Lai, Cheuk Wan Yim, Pui Yan Wong, Man Chi Leung, Woon Leung Ng
AIM: It is generally accepted that hyperuricemia is commonly associated with psoriatic arthritis (PsA). However, variations in ethnicity, diet and habitat may contribute to differences in prevalence and risk factors for hyperuricemia in PsA patients. Moreover, Asian specific data is deficient. The primary objective of the present study was to determine the prevalence of hyperuricemia among PsA patients. The secondary objective was to explore its associated risk factors. METHODS: This was a multi-center, cross-sectional observational study of 160 PsA patients from local Rheumatology clinics...
April 2018: International Journal of Rheumatic Diseases
Hamida Bouhenni, Hadjer Daoudi, Haidar Djemai, Philippe Noirez, Abdelkader Rouabah, Damien Vitiello, Leila Rouabah
Background Association of hyperuricemia, dyslipidemia and high blood pressure (BP) among adolescents with high waist-to-height ratio (WHtR) remains not fully addressed and could represent a new way to diagnose adolescents early with cardiometabolic risk. Objective We aimed to determine abdominal obesity (AO) prevalence and investigate relations between AO, uric acid (UA), lipid profiles, BP and geographical patterns in adolescents. Subjects 577 and 204 Algerian students aged between 10 and 19 years were included in our epidemiological and biochemical studies, respectively...
November 23, 2017: International Journal of Adolescent Medicine and Health
Ľ Cibičková, K Langová, H Vaverková, V Kubíčková, D Karásek
Hyperuricemia has been described as associated with the risk of development metabolic syndrome; however the relationship between the uric acid level and particular parameters of metabolic syndrome remained unclear. We performed a cross-sectional study on a cohort of 833 dyslipidemic patients and correlated their levels of uric acid with parameters of insulin resistance, lipid metabolism, C-reactive protein, anthropometric parameters. We also defined patients with hypertriglyceridemic waist phenotype and compered their uric acid levels with those without this phenotype...
February 28, 2017: Physiological Research
Yunes Panahi, Parisa Kianpour, Reza Mohtashami, Ramezan Jafari, Luis E Simental-Mendía, Amirhossein Sahebkar
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is one of the most common hepatic diseases in the general adult population. Dyslipidemia, hyperuricemia, and insulin resistance are common risk factors and accompanying features of NAFLD. Curcumin is a dietary natural product with beneficial metabolic effects relevant to the treatment of NAFLD. AIM: To assess the effects of curcumin on metabolic profile in subjects with NAFLD. METHODS: Patients diagnosed with NAFLD (grades 1-3; according to liver sonography) were randomly assigned to curcumin (1000 mg/d in 2 divided doses) (n = 50) or control (n = 52) group for a period of 8 weeks...
September 2016: Journal of Cardiovascular Pharmacology
Roberto Hidalgo y Teran Elizondo, Francisco Manuel Martín Bermudo, Ricardo Peñaloza Mendez, Genoveva Berná Amorós, Eleazar Lara Padilla, Francisco José Berral de la Rosa
INTRODUCTION: nutritional intake and status of soccer players has attracted not much research attention. Many soccer players follow an inadequate nutritional intake and have a poor nutritional status. This is relevant in youngsters soccer players, in order to improve performance and promote healthy dietary practices. AIMS: analyze anthropometric characterizes, evaluate nutritional intake and status, dietary habits and pre- and post-exercise meals in elite teenagers soccer players...
October 1, 2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Yi Chun Lai, Yik Weng Yew
BACKGROUND: Psoriasis is known to be associated with metabolic syndrome, a well-established risk factor for ischemic heart disease and stroke. Emerging evidence indicates that psoriasis is an independent risk factor for cardiovascular disease and stroke. OBJECTIVE: To evaluate whether psoriasis is independently associated with myocardial infarction (MI), ischemic heart disease (MI, angina pectoris, or coronary heart disease), and stroke, we conducted a cross-sectional study using the US National Health and Nutrition Examination Survey (NHANES) database...
July 2016: Journal of Cutaneous Medicine and Surgery
Kuihua Li, Xifu Wang, Yuling Liu, Lu Li, Shiq Xu, Xiaobo Tong, Lide Xie, Weijuan Yao
Hyperuricemia is a risk factor for various diseases, but knowledge on acute hyperuricemia is still not sufficient. The present study was aimed to investigate the effect of acute hyperuricemia on red blood cells from hemorheological point of view, and to provide the reference for clinical treatment. The rats were gavaged with 500 mg/kg hypoxanthine and intraperitoneally injected with 100 mg/kg oxonate to induce the model of acute hyperuricemia. The same volume of blood samples were drawn within time period of 0, 1, 2, 3 and 6 h, respectively, from the inner canthus of rats to measure the serum uric acid, hemorheological parameters and the malondialdehyde level...
April 2015: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
Ryuji Chida, Itaru Hisauchi, Shigeru Toyoda, Migaku Kikuchi, Takaaki Komatsu, Yuichi Hori, Shiro Nakahara, Yoshihiko Sakai, Teruo Inoue, Isao Taguchi
Hyperuricemia is a known cardiovascular risk factor. The angiotensin II receptor blocker (ARB) losartan is known to decrease serum uric acid (UA) level. A recent in vitro study demonstrated a strong interaction between irbesartan and UA transporters that exceeded that of losartan. The purpose of the present study was to evaluate the hypouricemic effect of irbesartan in a clinical setting. A total of 40 high-risk hypertensive outpatients with coronary artery disease, cerebrovascular disease and/or diabetes complications who were taking ARBs other than irbesartan and losartan were enrolled in this study...
November 2015: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Cihan Fidan, Aslı Kantar, Esra Baskın, Kaan Gülleroğlu, Aydıncan Akdur, Gökhan Moray, Mehmet Haberal
OBJECTIVES: Hyperuricemia is common in pediatric renal transplant recipients, and it is associated with poor allograft outcomes. Hyperuricemia occurs early after transplant and is associated with use of diuretics, cyclosporine therapy, a history of hyperuricemia, and decreased glomerular filtration rate. We aimed to investigate causes and effects of hyperuricemia on allograft outcomes in our patients. MATERIALS AND METHODS: There were 81 pediatric transplant patients (41 female and 40 male) included in the study...
April 2015: Experimental and Clinical Transplantation
E V Pavlovskaia, T V Strokova, A G Surkov, A R Bogdanov, G V Borodina, E N Kutyreva, T B Sentsova
The age-dependent nutritional status and resting metabolism in overweight and obese children have been examined. The study included 625 children of 2.5-17 years old. Patients were divided into three groups: 1st--2.5-7 years old (n = 49), 2nd--8-12 years old (n = 204), 3rd--13-17 years old (n = 372). The diagnosis of overweight and obesity was based on CDC criteria: children with 85-94 BMI percentile according to age and gender had overweight, BMI 295 percentile--obesity. Anthropometry, bioelectric impedance analysis and indirect respiratory calorimetry were performed; lipid and carbohydrate parameters were measured...
2014: Voprosy Pitaniia
Amparo Vayá, Leonor Rivera, Antonio Hernández-Mijares, Daniel Bautista, Eva Solá, Marco Romagnoli, Rafael Alis, Begoña Laiz
Several studies have found an association between hyperuricemia and metabolic syndrome (MS), although there are discrepancies as to which MS components play a pivotal role in this association. We aimed to investigate the association between serum uric acid (SUA) levels and MS in a Mediterranean population (eastern Spain). We performed a case-control study of 71 patients with MS and 122 healthy controls. MS was defined according to the revised National Cholesterol Education Program Adult Treatment Panel III modified criteria...
2015: Clinical Hemorheology and Microcirculation
Beata Bergler-Czop, Dominika Wcisło-Dziadecka, Ligia Brzezińska-Wcisło
Madelung's disease (benign symmetric lipomatosis, Launois-Bensaude syndrome) was described for the first time in the middle of the 19(th) century. This disorder concerns mainly men between 30 and 60 years of age. Patients often suffer from coexisting ailments, such as hepatic function disorders, polyneuropathy, diabetes, gynecomastia, hyperuricemia and deviations of lipid management parameters. Treatment of benign symmetric lipomatosis consists mainly in fat tissue sucking or injection lipolysis. Patients often have to wear special clothes correcting the deformed figure...
May 2014: Postȩpy Dermatologii i Alergologii
Juan Xu, Hao Peng, Qinghua Ma, Xiaohua Zhou, Wenxin Xu, Liang Huang, Jiarong Hu, Yonghong Zhang
BACKGROUND: Increased serum uric acid (SUA) is associated with dyslipidemia. However, there are conflicting data about the role of single lipid species including non-high density lipoprotein cholesterol (non-HDL-C) in promoting SUA accumulation. Here, we aimed to compare non-HDL-C with other traditional blood lipid profiles in relation to hyperuricemia in a middle-aged and elderly Chinese population. METHODS: Data was collected from 9580 participants undergoing routine physical examinations in Xiangcheng district of Suzhou...
July 23, 2014: Lipids in Health and Disease
Tsutomu Kazumi, Tsutomu Hirano, Gen Yoshino, For The Fenofibrate Study Group
BACKGROUND: A slight increase in albuminuria (urinary albumin excretion [UAE] ≥30 mg/d) is associated with hypertension, type 2 diabetes mellitus, dyslipidemia (high triglyceride [TG] and low high-density lipoprotein cholesterol [HDL-C] concentrations), and hyperuricemia. Although antihypertensive and antidiabetic therapies have been reported to reduce UAE, an association between improvement in dyslipidemia and/or hyperuricemia and a reduction in UAE has not been reported. OBJECTIVE: The aim of this study was to investigate the efficacy and tolerability of fenofibrate on albuminuria in patients with hypertriglyceridemia and/or hyperuricemia...
July 2003: Current Therapeutic Research, Clinical and Experimental
Te-Fu Chan, Wei-Ting Lin, Yi-Ling Chen, Hsiao-Ling Huang, Wei-Zeng Yang, Chun-Ying Lee, Meng-Hsueh Chen, Tsu-Nai Wang, Meng-Chuan Huang, Yu-Wen Chiu, Chun-Chi Huang, Sharon Tsai, Chih-Lung Lin, Chien-Hung Lee
BACKGROUND: The metabolic effect of fructose in sugar-sweetened beverages (SSB) has been linked to de novo lipogenesis and uric acid (UA) production. OBJECTIVES: This study investigated the biological effects of SSB consumption on serum lipid profiles and retinol-binding protein 4 (RBP4) among Taiwanese adolescents. METHODS: We evaluated the anthropometric parameters and biochemical outcomes of 200 representative adolescents (98 boys and 102 girls) who were randomly selected from a large-scale cross-sectional study...
2014: PloS One
Andreas Oberbach, Jochen Neuhaus, Thomas Inge, Katharina Kirsch, Nadine Schlichting, Susann Blüher, Yvonne Kullnick, Joachim Kugler, Sven Baumann, Holger Till
OBJECTIVE: Serum uric acid (sUA) is believed to contribute to the pathogenesis of metabolic comorbidities like hypertension, insulin-resistance (IR) and endothelial dysfunction (EDF) in obese children. The present pilot study investigated the association between sUA concentrations and loss of body weight following laparoscopic sleeve gastrectomy (LSG) or laparoscopic Roux-en-Y-gastric bypass (RYGB) in severely obese adolescents. MATERIALS/METHODS: 10 severely obese adolescents underwent either LSG (n=5) or RYGB (n=5)...
February 2014: Metabolism: Clinical and Experimental
C A Alikor, P C Emem-Chioma, O J Odia
INTRODUCTION: Hyperuricemia is a cardiovascular disease risk factor that has been poorly researched into in Africa and its prevalence is largely unknown in the rural areas in Nigeria and in the Niger Delta region of Nigeria in particular. METHODS: A cross-sectional rural survey involving 500 subjects aged 15 years and above. Demographic and social data were obtained using a questionnaire. Anthropometric (height, weight, waist circumference) and blood pressure measurements were taken...
July 2013: Nigerian Journal of Medicine: Journal of the National Association of Resident Doctors of Nigeria
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