keyword
MENU ▼
Read by QxMD icon Read
search

Clevidipine

keyword
https://www.readbyqxmd.com/read/28958611/clevidipine-for-hypertension-treatment-in-pheochromocytoma-surgery
#1
C Luis-García, E Arbonés-Aran, C Teixell-Aleu, L Lorente-Poch, L Trillo-Urrutia
Pheochromocytoma is a catecholamine-producing tumour and laparoscopic adrenalectomy is its treatment of choice. During pneumoperitoneum insufflation and tumour handling there is a high risk of massive catecholamine release and hypertensive crisis. After tumour excision, severe arterial hypotension is a common effect, due to relative vasodilation and the residual effect of antihypertensive drugs. We report the case of a patient with pheochromocytoma who was treated with laparoscopic adrenalectomy. During surgical manipulation there was a sudden hypertensive peak that could be controlled quickly with clevidipine infusion...
September 25, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28820038/comparison-of-clevidipine-and-nicardipine-for-acute-blood-pressure-reduction-in-patients-with-stroke
#2
Teresa A Allison, Stephanie Bowman, Brian Gulbis, Heather Hartman, Sara Schepcoff, Kiwon Lee
OBJECTIVE: The aim of this study was to determine whether clevidipine (CLEV) achieved faster blood pressure control compared to nicardipine (NIC) in patients presenting with either an acute ischemic stroke (AIS) or a spontaneous intracerebral hemorrhage (ICH). METHODS: This was a retrospective, observational, cohort study conducted in patients with AIS or ICH admitted to the emergency department of a Comprehensive Stroke Center from November 2011 to June 2013 who received CLEV or NIC continuous infusion for acute blood pressure management...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28707762/pharmacokinetics-and-tissue-distribution-study-of-clevidipine-and-its-primary-metabolite-h152-81-in-rats
#3
Yan Wang, Lanting Zhao, Tengfei Li, Wen Yang, Qian Li, Luning Sun, Li Ding
This present study was designed to investigate the pharmacokinetic profiles and tissue distribution characteristics of clevidipine and its primary metabolite H152/81 in rats following a single intravenous administration of clevidipine butyrate injectable emulsion (CBIE). For this study, a sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was established and validated for the simultaneous quantitation of clevidipine and H152/81 in rat whole blood and various tissues. A Hedera ODS-2 column with two gradient elution programs was employed for the troubleshooting of matrix effect on the detection of analytes among different biological samples...
July 14, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28669696/clevidipine-versus-sodium-nitroprusside-in-acute-aortic-dissection-a-retrospective-chart-review
#4
Alexandru Ulici, Jon Jancik, Timothy S Lam, Shannon Reidt, Domenico Calcaterra, Jon B Cole
AIM: Intravenous vasodilators are often added to beta-blocking agents to reach blood pressure (BP) goals in aortic dissection. Control of BP using clevidipine has been described in hypertensive emergencies and cardiac surgery but not in aortic dissection. The aim of this study was to compare clevidipine versus sodium nitroprusside (SNP) as adjunct agents to esmolol for BP management in aortic dissection. METHODS: A single-center retrospective chart review evaluated patients diagnosed with aortic dissection...
October 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28009636/intravenous-clevidipine-for-inducing-hypotensive-challenge-during-carotid-balloon-test-occlusion
#5
Nicholas Tarlov, Omar Kass-Hout, Lee R Guterman, Adnan I Qureshi
No abstract text is available yet for this article.
December 22, 2016: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/27995512/clevidipine-versus-nicardipine-for-acute-blood-pressure-reduction-in-a-neuroscience-intensive-care-population
#6
COMPARATIVE STUDY
Jacqueline R Finger, Lisa M Kurczewski, Gretchen M Brophy
BACKGROUND: Currently, a lack of published literature exists regarding the use of clevidipine in the neuroscience population. This agent may be preferred in some patients because of its short half-life, potentially leading to more narrow blood pressure (BP) control in comparison with other agents. The purpose of this study was to compare the difference in time to achieve target systolic blood pressure (SBP) goals with clevidipine versus nicardipine infusions in patients admitted to the neuroscience intensive care unit (NSICU) at our institution...
April 2017: Neurocritical Care
https://www.readbyqxmd.com/read/27757002/therapeutic-interchange-of-clevidipine-for-sodium-nitroprusside-in-cardiac-surgery
#7
Joseph E Cruz, Zachariah Thomas, David Lee, David M Moskowitz, Jeff Nemeth
BACKGROUND: Generic price inflation has resulted in rising acquisition costs for sodium nitroprusside (SNP), an agent historically described as the drug of choice for the treatment of perioperative hypertension in cardiac surgery. PURPOSE: To describe the implementation and cost avoidance achieved by utilizing clevidipine as an alternative to SNP in cardiac surgery patients at a 520-bed community teaching hospital that performs more than 300 cardiac surgeries each year...
October 2016: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/27495792/clevidipine-induced-dyspnea-relief-in-acute-heart-failure-patients
#8
LETTER
Nicoleta Stoicea, Nicholas Joseph, Sergio D Bergese
No abstract text is available yet for this article.
August 2016: EBioMedicine
https://www.readbyqxmd.com/read/27354747/comparison-of-clevidipine-versus-sodium-nitroprusside-for-the-treatment-of-postoperative-hypertension-in-cardiac-surgery-patients
#9
Natalie A Freiberger, Katie B Tellor, Alison M Stevens
OBJECTIVE: To evaluate the efficacy and safety of clevidipine (CLV) versus sodium nitroprusside (SNP) for the treatment of hypertension (HTN) in postoperative cardiac surgery patients at a community hospital. METHODS: This single-center, retrospective, cohort study included cardiac surgery patients treated with CLV or SNP for postoperative systolic blood pressure (SBP) control. The primary efficacy outcome was defined as the mean number of times the SBP rose above 140 mm Hg...
June 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27349457/high-affinity-complexes-of-pannexin-channels-and-l-type-calcium-channel-splice-variants-in-human-lung-possible-role-in-clevidipine-induced-dyspnea-relief-in-acute-heart-failure
#10
Gerhard P Dahl, Gregory E Conner, Feng Qiu, Junjie Wang, Edward Spindler, Jason A Campagna, H Peter Larsson
UNLABELLED: Clevidipine, a dihydropyridine (DHP) analogue, lowers blood pressure (BP) by inhibiting l-type calcium channels (CaV1.2; gene CACNA1C) predominantly located in vascular smooth muscle (VSM). However, clinical observations suggest that clevidipine acts by a more complex mechanism. Clevidipine more potently reduces pulmonary vascular resistance (PVR) than systemic vascular resistance and its spectrum of effects on PVR are not shared by other DHPs. Clevidipine has potent spasmolytic effects in peripheral arteries at doses that are sub-clinical for BP lowering and, in hypertensive acute heart failure, clevidipine, but not other DHPs, provides dyspnea relief, partially independent of BP reduction...
August 2016: EBioMedicine
https://www.readbyqxmd.com/read/27018586/perioperative-use-of-clevidipine-a-systematic-review-and-meta-analysis
#11
REVIEW
Angel Espinosa, Javier Ripollés-Melchor, Rubén Casans-Francés, Alfredo Abad-Gurumeta, Sergio D Bergese, Alix Zuleta-Alarcon, Francisco López-Timoneda, José María Calvo-Vecino
BACKGROUND: Clevidipine is an ultrashort-acting drug for rapid reduction of blood pressure by selectively acting on the L-type Ca2+ channels on arteriolar smooth muscle. The drug's ultrashort action in reducing the blood pressure is due to its rapid hydrolysis by blood and extravascular tissue esterases, which does not depend on hepato-renal metabolism and excretion. An analysis of the perioperative management of blood pressure should be considered to compare with other intravenous antihypertensive agents...
2016: PloS One
https://www.readbyqxmd.com/read/26850077/agents-with-vasodilator-properties-in-acute-heart-failure
#12
REVIEW
Abhishek Singh, Saïd Laribi, John R Teerlink, Alexandre Mebazaa
Millions of patients worldwide are admitted for acute heart failure (AHF) each year and physicians caring for these patients are confronted with the short-term challenges of reducing symptoms while preventing end organ dysfunction without causing additional harm, and the intermediate-term challenges of improving clinical outcomes such as hospital readmission and survival. There are limited data demonstrating the efficacy of any currently available therapies for AHF to meet these goals. After diuretics, vasodilators are the most common intravenous therapy for AHF, but neither nitrates, nitroprusside, nor nesiritide have robust evidence supporting their ability to provide meaningful effects on clinical outcomes, except perhaps early symptom improvement...
February 4, 2016: European Heart Journal
https://www.readbyqxmd.com/read/26837176/-simultaneous-determination-of-clevidipine-butyrate-and-its-metabolite-clevidipine-acid-in-dog-blood-by-liquid-chromatography-tandem-mass-spectrometry
#13
Hui-hui Wei, Yuan Gu, Yan-ping Liu, Guang-li Wei, Yong Chen, Chang-xiao Liu, Duan-yun Si
A rapid, sensitive and simple liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of clevidipine butyrate and its primary metabolite clevidipine acid in dog blood. After one-step protein precipitation with methanol, the chromatographic separation was carried out on an Ecosil C18 column (150 mm x 4.6 mm, 5 µm) with a gradient mobile phase consisting of methanol and 5 mmol · L(-1) ammonium formate. A chromatographic total run time of 13...
October 2015: Yao Xue Xue Bao, Acta Pharmaceutica Sinica
https://www.readbyqxmd.com/read/26570192/531-clevidipine-versus-nicardipine-for-acute-blood-pressure-lowering-in-the-neuroscience-icu
#14
Jacqueline Finger, Lisa Kurczewski, Gretchen Brophy
No abstract text is available yet for this article.
December 2015: Critical Care Medicine
https://www.readbyqxmd.com/read/26570139/478-efficacy-and-safety-of-clevidipine-and-nicardipine-in-post-neurosurgery-patients
#15
Ola Elnadoury, Teena Abraham, Joseph Samide, Meggie Yuen, Erin Oh, Nasser Saad, Francesco Ciummo, Bashar Fahoum
No abstract text is available yet for this article.
December 2015: Critical Care Medicine
https://www.readbyqxmd.com/read/26489435/structural-analysis-and-quantitative-determination-of-clevidipine-butyrate-impurities-using-an-advanced-rp-hplc-method
#16
Yuxia Zhou, Fan Zhou, Fei Yan, Feng Yang, Yuxian Yao, Qiaogen Zou
Eleven potential impurities, including process-related compounds and degradation products, have been analyzed by comprehensive studies on the manufacturing process of clevidipine butyrate. Possible formation mechanisms could also be devised. MS and NMR techniques have been used for the structural characterization of three previously unreported impurities (Imp-3, Imp-5 and Imp-11). To separate and quantify the potential impurities in a simultaneous fashion, an efficient and advanced RP-HPLC method has been developed...
March 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/26447497/the-effect-of-clevidipine-on-cerebral-blood-flow-velocity-and-carbon-dioxide-reactivity-in-human-volunteers
#17
Brian P Lemkuil, Brian T Gierl, Piyush M Patel, Matthew L Pearn, Liem C Nguyen, Anushirvan Minokadeh, John C Drummond
BACKGROUND: Clevidipine is a short acting, esterase metabolized, calcium channel antagonist administered as a continuous infusion for control of hypertension. Its profile allows for rapid titration and may be uniquely suited to achieving tight hemodynamic targets in neurosurgical and neurocritical care patients. The present study was designed to investigate the effect of clevidipine infusion on cerebral blood flow and cerebral CO2 responsiveness as measured by cerebral blood flow velocity (CBFV) using transcranial Doppler...
October 2016: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/26168253/screening-of-stabilizers-for-lc-ms-ms-analysis-of-clevidipine-and-its-primary-metabolite-in-dog-whole-blood
#18
Peng Cao, Gao Li, Ling Huang, Shouwei Zhao, Yang Hu, Lixia Qin, Lihui Qiu, Wenwen Zhu, Luqin Si, Jiangeng Huang
BACKGROUND: Clevidipine is an ester-containing antihypertensive agent that undergoes rapid hydrolysis in blood. A reliable stabilizer cocktail containing citric acid and ascorbic acid was established and the LC-MS/MS method was validated for simultaneous determination of clevidipine and its major metabolite in beagle dog whole blood. RESULTS: The stabilizer could nearly completely inhibit the esterase activity. Both analytes were extracted from whole blood by toluene and detected by MS/MS in positive ESI mode...
2015: Bioanalysis
https://www.readbyqxmd.com/read/25964966/clevidipine-hypertensive-crises-during-surgery-no-advance
#19
(no author information available yet)
Beware of hypersensitivity reactions to the lipid emulsion.
October 2014: Prescrire International
https://www.readbyqxmd.com/read/25859171/a-prospective-open-label-trial-of-clevidipine-for-controlled-hypotension-during-posterior-spinal-fusion
#20
Hiromi Kako, Andrew Gable, David Martin, Allan Beebe, Arlyne Thung, Walter Samora, Jan Klamar, Tarun Bhalla, Joseph D Tobias
OBJECTIVES: Controlled hypotension is one means to limit or avoid the need for allogeneic blood products. Clevidipine is a short-acting, intravenous calcium channel antagonist with a half-life of 1 to 3 minutes due to rapid metabolism by non-specific blood and tissue esterases. To date, there are no prospective evaluations with clevidipine in the pediatric population. We prospectively evaluated the dosing requirements, efficacy, and safety of clevidipine for ontrolled hypotension during spinal surgery for neuromuscular scoliosis in the pediatric population...
January 2015: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
keyword
keyword
67246
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"