Julie Werenberg Dreier, Jakob Christensen, Jannicke Igland, Mika Gissler, Maarit K Leinonen, Håkon Magne Vegrim, Yuelian Sun, Torbjörn Tomson, Helga Zoega, Marte-Helene Bjørk, Rebecca L Bromley
IMPORTANCE: Use of valproate and certain other antiseizure medications (ASMs) in pregnancy is associated with abnormal fetal brain development with potential long-term implications for the child. OBJECTIVE: To examine whether use of valproate and other ASMs in pregnancy among mothers with epilepsy is associated with epilepsy risk in their children. DESIGN, SETTING, AND PARTICIPANTS: This prospective, population-based register cohort study included singletons born to mothers with epilepsy in Denmark, Finland, Iceland, Norway, and Sweden from January 1, 1996, to December 31, 2017...
February 5, 2024: JAMA Network Open