keyword
MENU ▼
Read by QxMD icon Read
search

vaccines and autoimmunity

keyword
https://www.readbyqxmd.com/read/28444127/hla-class-i-binding-prediction-via-convolutional-neural-networks
#1
Yeeleng S Vang, Xiaohui Xie
Motivation: Many biological processes are governed by protein-ligand interactions. One such example is the recognition of self and nonself cells by the immune system. This immune response process is regulated by the major histocompatibility complex (MHC) protein which is encoded by the human leukocyte antigen (HLA) complex. Understanding the binding potential between MHC and peptides can lead to the design of more potent, peptide-based vaccines and immunotherapies for infectious autoimmune diseases...
April 21, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28440992/-autoimmune-inflammatory-syndrome-induced-by-adjuvants-a-new-clinical-entity
#2
Belkis Ferrer-Cosme, Damiana Téllez-Martínez, Alexander Batista-Duharte
Recently Shoenfeld and Agmon-Levin proposed a new clinical entity called autoimmune/inflammatory syndrome induced by adjuvants (ASIA), which includes four clinical entities called: 1) siliconosis, 2) Gulf War syndrome, 3) macrophage myofasciitis) and 4) post-vaccination phenomenon associated with adjuvants. They all have a common denominator: a prior exposure to immunoadjuvants, and, in addition, they also share several clinical criteria associated to chronic inflammation and autoimmune reactions. This proposal still needs to be validated by the scientific community, but nowadays is a topic of hot discussion in the literature and in various international conferences...
May 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28425447/development-and-pre-clinical-evaluation-of-recombinant-human-myelin-basic-protein-nano-therapeutic-vaccine-in-experimental-autoimmune-encephalomyelitis-mice-animal-model
#3
Medhat A Al-Ghobashy, Aliaa N ElMeshad, Rania M Abdelsalam, Mohammed M Nooh, Muhammad Al-Shorbagy, Götz Laible
Recombinant human myelin basic protein (rhMBP) was previously produced in the milk of transgenic cows. Differences in molecular recognition of either hMBP or rhMBP by surface-immobilized anti-hMBP antibodies were demonstrated. This indicated differences in immunological response between rhMBP and hMBP. Here, the activity of free and controlled release rhMBP poly(ε-caprolactone) nanoparticles (NPs), as a therapeutic vaccine against multiple sclerosis (MS) was demonstrated in experimental autoimmune encephalomyelitis (EAE) animal model...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28424682/interactions-between-type-1-interferons-and-the-th17-response-in-tuberculosis-lessons-learned-from-autoimmune-diseases
#4
REVIEW
Bas C Mourik, Erik Lubberts, Jurriaan E M de Steenwinkel, Tom H M Ottenhoff, Pieter J M Leenen
The classical paradigm of tuberculosis (TB) immunity, with a central protective role for Th1 responses and IFN-γ-stimulated cellular responses, has been challenged by unsatisfactory results of vaccine strategies aimed at enhancing Th1 immunity. Moreover, preclinical TB models have shown that increasing IFN-γ responses in the lungs is more damaging to the host than to the pathogen. Type 1 interferon signaling and altered Th17 responses have also been associated with active TB, but their functional roles in TB pathogenesis remain to be established...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28423140/arboviruses-emerging-in-brazil-challenges-for-clinic-and-implications-for-public-health
#5
Maria Rita Donalisio, André Ricardo Ribas Freitas, Andrea Paula Bruno Von Zuben
Arboviruses have been emerging in different parts of the world due to genetic changes in the virus, alteration of the host and vector population dynamics, or because of anthropogenic environmental factors. These viruses' capacity for adaptation is notable, as well as the likelihood of their emergence and establishment in new geographic areas. In Brazilian epidemiologic scenario, the most common arboviruses are DENV, CHIKV, and ZIKV, although others may spread in the country. Little is yet known of the impact of viral co-circulation, which would theoretically result in more intense viremia or other immunological alterations that could trigger autoimmune diseases, such as Guillain-Barré syndrome...
April 10, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28417344/biotherapy-in-inflammatory-diseases-of-the-cns-current-knowledge-and-applications
#6
REVIEW
Nicolas Collongues, Laure Michel, Jérôme de Seze
Biotherapy represents an innovative therapeutic approach that includes immunotherapy (vaccines, apheresis, and antibodies); gene therapy; and stem cell transplants. Their development helps to cross the bridge from bench to bedside and brings new hope of a cure for severe diseases in different fields of medicine. In neurology, a growing range of applications is being developed for these medications. Valuable results are now available in the field of autoimmunity, neuro-oncology, paraneoplastic manifestations, and neurodegenerative disorders...
May 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28399059/rotavirus-vaccination-and-the-risk-of-celiac-disease-or-type-1-diabetes-in-finnish-children-at-early-life
#7
Vaarala Outi, Jokinen Jukka, Lahdenkari Mika, Leino Tuija
Rotavirus infection has been suggested as a trigger of type 1 diabetes (T1D) and celiac disease (CD) related autoimmunity. We carried out a nationwide population-based cohort study evaluating whether prevention of rotavirus infection with vaccination affects the risk of CD and T1D diagnosed during 2009-2014 in Finnish children by comparing vaccinated and unvaccinated children in a cohort born in 2009-2010. Nationwide rotavirus vaccination records were collected from health-care databases during 2009-2011 and validated for a sample of 495 children born 7/2009-12/2009...
April 10, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28396185/from-lymphopoiesis-to-plasma-cells-differentiation-the-age-related-modifications-of-b-cell-compartment-are-influenced-by-inflamm-ageing
#8
REVIEW
Matteo Bulati, Calogero Caruso, Giuseppina Colonna-Romano
Ageing is a complex process characterized by a general decline in physiological functions with increasing morbidity and mortality. The most important aspect of ageing is the chronic inflammatory status, named "inflamm-ageing", strictly associated with the deterioration of the immune function, termed "immunosenescence". Both are causes of increased susceptibility of elderly to infectious diseases, cancer, dementia, cardiovascular diseases and autoimmunity, and of a decreased response to vaccination. It has been widely demonstrated that ageing has a strong impact on the remodelling of the B cell branch of immune system...
April 7, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28394823/human-papilloma-virus-and-lupus-the-virus-the-vaccine-and-the-disease
#9
Yahel Segal, Michele Calabrò, Darja Kanduc, Yehuda Shoenfeld
PURPOSE OF REVIEW: Systemic lupus erythematosus (SLE) is a well known, widespread autoimmune disease, involving multiple organ systems, with a multifaceted, widely unmapped etiopathogenesis. Recently, a new aspect of morbidity has been described among SLE patients: infection with human papilloma virus (HPV). We set out to review data regarding the intricate relationship between the two and attempt to determine whether HPV may pose as a contributing factor to the development of SLE. RECENT FINDINGS: We relate to epidemiological, molecular and clinical data...
April 7, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28393916/production-and-glyco-engineering-of-immunomodulatory-helminth-glycoproteins-in-plants
#10
Ruud H P Wilbers, Lotte B Westerhof, Kim van Noort, Katja Obieglo, Nicole N Driessen, Bart Everts, Sonja I Gringhuis, Gabriele Schramm, Aska Goverse, Geert Smant, Jaap Bakker, Hermelijn H Smits, Maria Yazdanbakhsh, Arjen Schots, Cornelis H Hokke
Helminth parasites control host-immune responses by secreting immunomodulatory glycoproteins. Clinical trials and mouse model studies have demonstrated the potential of helminth-derived glycoproteins for the treatment of immune-related diseases, like allergies and autoimmune diseases. Studies are however hampered by the limited availability of native parasite-derived proteins. Moreover, recombinant protein production systems have thus far been unable to reconstitute helminth-like glycosylation essential for the functionality of some helminth glycoproteins...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28393598/-zika-virus-infection-in-pregnancy
#11
Gabriella Varjasi, Róbert Póka
The Zika virus is a flavivirus spread by mosquitoes. Its primary vectors are the Aedes aegypti and the Aedes albopictus. Before 2007 it sporadically caused benign morbidity. Since 2015, it started spreading "explosively" in America, especially in Brazil. In August 2016 they reported cases from New York and Poland, too. Most of the infections don't produce any symptoms, but can cause grave complications. The most important lesion is microcephalia that forms in fetuses. Microcephalia's most serious consequence is mental retardation, which puts great burden on both the family and the society...
April 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28392305/engineering-self-assembled-materials-to-study-and-direct-immune-function
#12
Lisa H Tostanoski, Christopher M Jewell
The immune system is an awe-inspiring control structure that maintains a delicate and constantly changing balance between pro-immune functions that fight infection and cancer, regulatory or suppressive functions involved in immune tolerance, and homeostatic resting states. These activities are determined by integrating signals in space and time; thus, improving control over the densities, combinations, and durations with which immune signals are delivered is a central goal to better combat infectious disease, cancer, and autoimmunity...
April 6, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28390560/reproductive-health-screening-in-women-with-autoimmune-diseases
#13
REVIEW
Latisha Heinlen, Eliza F Chakravarty
Although the female predominance of autoimmune diseases is not completely understood, sex hormones are thought to play a role. Attention to lifelong reproductive health is especially important for women with autoimmune disorders. Many of these women require long-term immunosuppressive therapy that may affect their ability to clear infections, including viruses, and may alter natural tumor surveillance mechanisms. As a result, women with autoimmune diseases may have different risks for common reproductive-related malignancies that may in turn affect screening guidelines and other preventive measures, including vaccination...
May 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/28386258/role-of-anti-osteopontin-antibodies-in-multiple-sclerosis-and-experimental-autoimmune-encephalomyelitis
#14
Nausicaa Clemente, Cristoforo Comi, Davide Raineri, Giuseppe Cappellano, Domizia Vecchio, Elisabetta Orilieri, Casimiro L Gigliotti, Elena Boggio, Chiara Dianzani, Melissa Sorosina, Filippo Martinelli-Boneschi, Marzia Caldano, Antonio Bertolotto, Luca Ambrogio, Daniele Sblattero, Tiziana Cena, Maurizio Leone, Umberto Dianzani, Annalisa Chiocchetti
Osteopontin (OPN) is highly expressed in demyelinating lesions in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). OPN is cleaved by thrombin into N- (OPN-N) and C-terminal (OPN-C) fragments with different ligands and functions. In EAE, administering recombinant OPN induces relapses, whereas treatment with anti-OPN antibodies ameliorates the disease. Anti-OPN autoantibodies (autoAbs) are spontaneously produced during EAE but have never been detected in MS. The aim of the study was to evaluate anti-OPN autoAbs in the serum of MS patients, correlate them with disease course, and recapitulate the human findings in EAE...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28382773/the-yin-and-yang-of-regulatory-t-cells-in-infectious-diseases-and-avenues-to-target-them
#15
REVIEW
Emmanuel Stephen-Victor, Iris Bosschem, Freddy Haesebrouck, Jagadeesh Bayry
CD4(+) CD25(+) FoxP3(+) regulatory T cells (Tregs) are key players for maintaining immune tolerance. Tregs are critical for reducing the inflammation-mediated tissue damage following infection. However, Tregs also suppress protective immune responses to pathogens (including virus, bacteria, parasites and fungi) and vaccines, and enhance pathogen persistence by inhibiting the activation and functions of both innate and adaptive immune cells such as dendritic cells, macrophages, T and B lymphocytes, and by promoting immunosuppressive environment...
April 6, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28381540/therapeutic-treatment-of-marburg-and-ravn-virus-infection-in-nonhuman-primates-with-a-human-monoclonal-antibody
#16
Chad E Mire, Joan B Geisbert, Viktoriya Borisevich, Karla A Fenton, Krystle N Agans, Andrew I Flyak, Daniel J Deer, Herta Steinkellner, Ognian Bohorov, Natasha Bohorova, Charles Goodman, Andrew Hiatt, Do H Kim, Michael H Pauly, Jesus Velasco, Kevin J Whaley, James E Crowe, Larry Zeitlin, Thomas W Geisbert
As observed during the 2013-2016 Ebola virus disease epidemic, containment of filovirus outbreaks is challenging and made more difficult by the lack of approved vaccine or therapeutic options. Marburg and Ravn viruses are highly virulent and cause severe and frequently lethal disease in humans. Monoclonal antibodies (mAbs) are a platform technology in wide use for autoimmune and oncology indications. Previously, we described human mAbs that can protect mice from lethal challenge with Marburg virus. We demonstrate that one of these mAbs, MR191-N, can confer a survival benefit of up to 100% to Marburg or Ravn virus-infected rhesus macaques when treatment is initiated up to 5 days post-inoculation...
April 5, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28376584/a-novel-multi-epitope-vaccine-based-on-dipeptidyl-peptidase-4-prevents-streptozotocin-induced-diabetes-by-producing-anti-dpp4-antibody-and-immunomodulatory-effect-in-c57bl-6j-mice
#17
Zhixin Li, Jinzhi Fang, Rui Jiao, Xiaomin Wei, Yanjie Ma, Xiaoran Liu, Peng Cheng, Taiming Li
Type 1 diabetes is a chronic organ-specific autoimmune disease in which selective destruction of insulin-producing β-cells leads to impaired glucose metabolism and its attendant complications. A series of Dipeptidyl peptidase 4 (DPP4) inhibitors have been developed and granted approval in the treatment of type 2 diabetes mellitus by inhibiting the enzymatic degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). An increasing number of studies have shown the potential benefits of DPP4 inhibitors for type 1 diabetes...
March 31, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28368979/undifferentiated-connective-tissue-disease-fibromyalgia-and-the-environmental-factors
#18
Laura Andreoli, Angela Tincani
PURPOSE OF REVIEW: The aim of this study was to discuss the role of environmental factors in the induction and perpetuation of autoimmunity, with particular focus on undifferentiated connective tissue disease (UCTD) and fibromyalgia. These two entities may share undefined clinical and laboratory features and recognize environmental exposures as triggering factors. From this particular point of view, both UCTD and fibromyalgia may resemble the picture of the 'Autoimmune/Inflammatory Syndrome Induced by Adjuvants' (ASIA)...
March 31, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28353409/what-do-we-know-about-the-role-of-regulatory-b-cells-breg-during-the-course-of-infection-of-two-major-parasitic-diseases-malaria-and-leishmaniasis
#19
Roberta Reis Soares, Luciana Maria Ribeiro Antinarelli, Clarice Abramo, Gilson Costa Macedo, Elaine Soares Coimbra, Kézia Katiani Gorza Scopel
Parasitic diseases, such as malaria and leishmaniasis, are relevant public health problems worldwide. For both diseases, the alarming number of clinical cases and deaths reported annually has justified the incentives directed to better understanding of host's factors associated with susceptibility to infection or protection. In this context, over recent years, some studies have given special attention to B lymphocytes with a regulator phenotype, known as Breg cells. Essentially important in the maintenance of immunological tolerance, especially in autoimmune disease models such as rheumatoid arthritis and experimentally induced autoimmune encephalomyelitis, the function of these lymphocytes has so far been poorly explored during the course of diseases caused by parasites...
March 29, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28352656/trafficking-receptor-signatures-define-blood-plasmablasts-responding-to-tissue-specific-immune-challenge
#20
Yekyung Seong, Nicole H Lazarus, Lusijah Sutherland, Aida Habtezion, Tzvia Abramson, Xiao-Song He, Harry B Greenberg, Eugene C Butcher
Antibody-secreting cells are generated in regional lymphoid tissues and traffic as plasmablasts (PBs) via lymph and blood to target sites for local immunity. We used multiparameter flow cytometry to define PB trafficking programs (TPs, combinations of adhesion molecules and chemoattractant receptors) and their imprinting in patients in response to localized infection or immune insults. TPs enriched after infection or autoimmune inflammation of mucosae correlate with sites of immune response or symptoms, with different TPs imprinted during small intestinal, colon, throat, and upper respiratory immune challenge...
March 23, 2017: JCI Insight
keyword
keyword
67240
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"