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https://www.readbyqxmd.com/read/27926769/myocardial-fibrosis-progression-in-duchenne-and-becker-muscular-dystrophy-a-randomized-clinical-trial
#1
Marly Conceição Silva, Tiago Augusto Magalhães, Zilda Maria Alves Meira, Carlos Henrique Reis Esselin Rassi, Amanda Cristina de Souza Andrade, Paulo Sampaio Gutierrez, Clerio Francisco Azevedo, Juliana Gurgel-Giannetti, Mariz Vainzof, Mayana Zatz, Roberto Kalil-Filho, Carlos Eduardo Rochitte
Importance: In Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), interventions reducing the progression of myocardial disease could affect survival. Objective: To assess the effect of early angiotensin-converting enzyme (ACE) inhibitor therapy in patients with normal left ventricular function on the progression of myocardial fibrosis (MF) identified on cardiovascular magnetic resonance (CMR). Design, Setting, and Participants: A randomized clinical trial conducted in 2 centers included 76 male patients with DMD or BMD undergoing 2 CMR studies with a 2-year interval for ventricular function and MF assessment...
December 7, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27926762/association-of-arterial-and-lymph-node-inflammation-with-distinct-inflammatory-pathways-in-human-immunodeficiency-virus-infection
#2
Ahmed Tawakol, Amorina Ishai, Danny Li, Richard A P Takx, Sophia Hur, Yannick Kaiser, Miguel Pampaloni, Adam Rupert, Denise Hsu, Irini Sereti, Rémi Fromentin, Nicolas Chomont, Peter Ganz, Steven G Deeks, Priscilla Y Hsue
Importance: Human immunodeficiency virus (HIV) infection is associated with a high risk of cardiovascular disease and increased arterial inflammation. In HIV, inflammation is also increased within lymph nodes (LNs), tissues known to harbor the virus even among treated and suppressed individuals. Objective: To test the hypothesis that arterial inflammation is linked to HIV disease activity and to inflammation within HIV-infected tissues (LNs). Design, Setting, and Participants: For this case-control study, participants were recruited from the SCOPE (Observational Study of the Consequences of the Protease Inhibitor Era) cohort, a clinic-based cohort of individuals receiving care at San Francisco General Hospital and the San Francisco Veteran's Affairs Medical Center...
December 7, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27926633/effects-of-calcium-vitamin-d-and-hormone-therapy-on-cardiovascular-disease-risk-factors-in-the-women-s-health-initiative-a-randomized-controlled-trial
#3
Peter F Schnatz, Xuezhi Jiang, Aaron K Aragaki, Matthew Nudy, David M OʼSullivan, Mark Williams, Erin S LeBlanc, Lisa W Martin, JoAnn E Manson, James M Shikany, Karen C Johnson, Marcia L Stefanick, Martha E Payne, Jane A Cauley, Barbara V Howard, John Robbins
OBJECTIVE: To analyze the treatment effect of calcium+vitamin D supplementation, hormone therapy, both, and neither on cardiovascular disease risk factors. METHODS: We conducted a prospective, randomized, double-blind, placebo-controlled trial among Women's Health Initiative (WHI) participants. The predefined primary outcome was low-density lipoprotein cholesterol (LDL-C). RESULTS: Between September 1993 and October 1998, a total of 68,132 women aged 50-79 years were recruited and randomized to the WHI-Dietary Modification (n=48,835) and WHI-Hormone Therapy trials (n=27,347)...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27924618/cardiovascular-disease-risk-factors-and-health-outcomes-among-american-indians-in-oklahoma-the-thrive-study
#4
Valarie Blue Bird Jernigan, Marianna Wetherill, Jordan Hearod, Tvli Jacob, Alicia L Salvatore, Tamela Cannady, Mandy Grammar, Joy Standridge, Jill Fox, Jennifer Spiegel, AnDina Wiley, Carolyn Noonan, Dedra Buchwald
INTRODUCTION: Limited available data document higher prevalences of cardiovascular disease (CVD) risk factors and health outcomes among American Indians (AIs) compared to other racial/ethnic groups. METHODS: As part of a randomized control trial to improve tribal food and physical activity environments, our tribal-academic partnership surveyed a cross-sectional sample of American Indian adults (n = 513) to assess the prevalence of type 2 diabetes, obesity, hypertension, tobacco use, physical activity, and vegetable and fruit intake...
December 6, 2016: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/27924429/cyp2c19-lof-and-gof-guided-antiplatelet-therapy-in-patients-with-acute-coronary-syndrome-a-cost-effectiveness-analysis
#5
Minghuan Jiang, Joyce H S You
PURPOSE: This study aimed to examine the cost-effectiveness of CYP2C19 loss-of-function and gain-of-function allele guided (LOF/GOF-guided) antiplatelet therapy in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). METHODS: A life-long decision-analytic model was designed to simulate outcomes of three strategies: universal clopidogrel (75 mg daily), universal alternative P2Y12 inhibitor (prasugrel 10 mg daily or ticagrelor 90 mg twice daily), and LOF/GOF-guided therapy (LOF/GOF allele carriers receiving alternative P2Y12 inhibitor, wild-type patients receiving clopidogrel)...
December 7, 2016: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/27924361/prevalence-of-non-cardiovascular-findings-on-ct-angiography-in-children-with-congenital-heart-disease
#6
Archana Malik, Jeffrey C Hellinger, Sabah Servaes, Mathew C Schwartz, Marc S Keller, Monica Epelman
BACKGROUND: CT angiography is gaining broader acceptance in the evaluation of children with known or suspected congenital heart disease. These studies include non-cardiovascular structures such as the mediastinum, lung parenchyma and upper abdominal organs. It is important to inspect all these structures for potential abnormalities that might be clinically important and, in some cases, may impact care plans. OBJECTIVE: To determine the prevalence of non-cardiovascular findings in CT angiography of children with congenital heart disease...
December 6, 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27924055/lifestyle-interventions-to-prevent-cardiovascular-events-after-stroke-and-transient-ischemic-attack-systematic-review-and-meta-analysis
#7
Inger A Deijle, Sander M Van Schaik, Erwin E H Van Wegen, Henry C Weinstein, Gert Kwakkel, Renske M Van den Berg-Vos
BACKGROUND AND PURPOSE: Patients with a transient ischemic attack or ischemic stroke have an increased risk of subsequent cardiovascular events. The purpose of this systematic review and meta-analysis was to determine whether lifestyle interventions focusing on behaviorally modifiable risk factors with or without an exercise program are effective in terms of (1) preventing recurrent cardiovascular events, (2) reducing mortality, and (3) improving modifiable risk factors associated with cardiovascular disease in patients after a transient ischemic attack or ischemic stroke...
December 6, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27923462/prognostic-implications-of-newly-developed-t-wave-inversion-after-primary-percutaneous-coronary-intervention-in-patients-with-st-segment-elevation-myocardial%C3%A2-infarction
#8
Man-Jong Lee, Ji-Hoon Jang, Myung-Dong Lee, Sung Woo Kwon, Sung-Hee Shin, Sang-Don Park, Seong-Ill Woo, Dae-Hyeok Kim, Jun Kwan, Keum-Soo Park
We investigated the prognostic value of newly developed T-wave inversion after primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction. New T-wave inversion was defined as new onset of T-wave inversion after the primary PCI, without negative T waves on the presenting electrocardiogram. The primary end point was the occurrence of major adverse cardiac events (MACE), which consisted of cardiovascular mortality, nonfatal myocardial infarction, and rehospitalization for heart failure...
November 16, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27923459/micrornas-in-lipid-metabolism-and-atherosclerosis
#9
REVIEW
Hector Giral, Adelheid Kratzer, Ulf Landmesser
Numerous studies have examined the role of microRNAs (miRNAs) in cell homeostasis and cardiovascular disease and have markedly improved our understanding of RNA biology in general and the potential role of miRNAs in atherosclerosis. In atherosclerosis, several miRNAs, such as miR-33a,b, miR-92a, miR-126 and others, have been identified that are relevant mediators of pathological processes, including regulation of cholesterol and lipid biosynthesis, lipoprotein metabolism and cholesterol efflux, but also immune responses, endothelial cell biology and vascular function...
October 2016: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/27922919/association-between-sarcopenia-and-metabolic-syndrome-in-cancer-survivors
#10
Su Jung Lee, Nam Cho Kim
BACKGROUND: Advanced cancer treatments have improved survival from cancer, but the incidence of cardiovascular disease in survivors has recently increased. Sarcopenia and metabolic syndrome (MetS) are related to cancer survival, and sarcopenia is an emerging risk factor for cardiovascular disease. However, evidence of a relationship between sarcopenia and MetS in cancer survivors is lacking. OBJECTIVES: The aims of this study were to determine the prevalence of sarcopenia and MetS in cancer survivors and to investigate independent predictors of MetS in cancer survivors...
December 5, 2016: Cancer Nursing
https://www.readbyqxmd.com/read/27921047/pharmacological-interventions-against-obesity-current-status-and-future-directions
#11
REVIEW
Bernd Schultes
The metabolic syndrome (MS) comprises a cluster of metabolic disturbances including obesity, hyperglycemia, dyslipidemia, and elevated blood pressure that are pathophysiologically highly interlinked and that altogether lead to an increased cardiovascular (CV) risk. While lifestyle interventions represent the basic therapeutic measure to address all components of the MS, they are in most cases not effective enough to reduce the CV risk. Therefore, pharmacological interventions are necessary for many patients...
October 2016: Visceral Medicine
https://www.readbyqxmd.com/read/27919826/should-blood-pressure-goal-be-individualized-in-hypertensive-patients
#12
REVIEW
Alexandra Yannoutsos, Rania Kheder-Elfekih, Jean-Michel Halimi, Michel E Safar, Jacques Blacher
The aim of the present review is to consider the clinical relevance of individualized blood pressure (BP) goal under treatment in hypertensive patients according to their age, comorbidities or established cardiovascular (CV) disease. Evidence from large-scale randomized trials to support a lower BP goal, as initially recommended by guidelines in high-risk hypertensive patients, were lacking. Recently, the randomized intervention SPRINT trial studied two treatment targets for systolic BP (120mm Hg versus 140mm Hg in the intensive and standard treatment group, respectively) among high-risk hypertensive patients, without diabetes and without a history of prior stroke...
December 2, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27919637/critical-hand-ischemia-treatment-via-orbital-atherectomy-a-single-center-observational-retrospective-analysis
#13
Abdul Bahro, Zsuzsanna Igyarto, Brad Martinsen
BACKGROUND/PURPOSE: Critical hand ischemia (CHI) can be devastating and may result in amputation. Distal vessel calcification has been shown to be a major factor in causing CHI. Atherectomy in the upper extremities is not typically considered due to the small anatomy; however, the Diamondback 360° Peripheral Orbital Atherectomy System (OAS) (Cardiovascular Systems, Inc.) can access treatment areas with a reference vessel diameter of 1.5mm. METHODS/MATERIALS: A retrospective, observational, single center (Merit Health Center, Jackson, MS) analysis of 11 CHI patients with calcific disease of the radial artery treated with orbital atherectomy (OAS) was completed...
October 29, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/27919355/model-observational-bridging-study-on-the-effectiveness-of-ezetimibe-on-cardiovascular-morbidity-and-mortality-in-france-a-population-based-study
#14
Jean Ferrières, Jean Dallongeville, Michel Rossignol, Jacques Bénichou, J Jaime Caro, Denis Getsios, Luis Hernandez, Lucien Abenhaim, Lamiae Grimaldi-Bensouda
BACKGROUND: To evaluate the real-life impact of ezetimibe on cardiovascular (CV) morbidity and mortality in France. OBJECTIVE: To estimate the number of non-fatal and fatal CV events that could be prevented and corresponding number of patients needed to treat (NNT) with ezetimibe to prevent one CV event over 5 years. METHODS: Non-interventional 48-month follow-up cohort conducted in hypercholesterolemic patients starting on ezetimibe <3 months at study entry, either as monotherapy or combined with statins...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27919338/effects-of-ionizing-radiation-on-the-heart
#15
Marjan Boerma, Vijayalakshmi Sridharan, Xiao-Wen Mao, Gregory A Nelson, Amrita K Cheema, Igor Koturbash, Sharda P Singh, Alan J Tackett, Martin Hauer-Jensen
This article provides an overview of studies addressing effects of ionizing radiation on the heart. Clinical studies have identified early and late manifestations of radiation-induced heart disease, a side effect of radiation therapy to tumors in the chest when all or part of the heart is situated in the radiation field. Studies in preclinical animal models have contributed to our understanding of the mechanisms by which radiation may injure the heart. More recent observations in human subjects suggest that ionizing radiation may have cardiovascular effects at lower doses than was previously thought...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/27918652/does-short-duration-heat-exposure-at-a-matched-cardiovascular-intensity-improve-intermittent-running-performance-in-a-cool-environment
#16
Calvin P Philp, Martin Buchheit, Cecilia M Kitic, Christopher T Minson, James W Fell
PURPOSE: To investigate whether a five-day cycling training block in the heat (35°C) in Australian rules footballers was superior to exercising at the same relative intensity in cool conditions (15°C) for improving intermittent running performance in a cool environment (<18°C). METHODS: Using a parallel-group design, 12 semi-professional football players performed five days of cycling exercise [70% heart rate reserve (HRR) for 45 min (5 x 50 min sessions in total)] in a hot (HEAT, 35±1°C, 56±9% RH) or cool environment (COOL, 15±3°C, 81±10% RH)...
December 5, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27918443/human-intervention-study-to-assess-the-effects-of-supplementation-with-olive-leaf-extract-on-peripheral-blood-mononuclear-cell-gene-expression
#17
Anna Boss, Chi Hsiu-Juei Kao, Pamela M Murray, Gareth Marlow, Matthew P G Barnett, Lynnette R Ferguson
Olive leaf extract (OLE) has been used for many years for its putative health benefits, but, to date, scientific evidence for the basis of these effects has been weak. Although recent literature has described a link between ailments such as cardiovascular disease, diabetes and cancer and a protective effect of polyphenols in the OLE, the mode of action is still unclear. Here, we describe a double-blinded placebo (PBO)-controlled trial, in which gene expression profiles of peripheral blood mononuclear cells from healthy male volunteers (n = 29) were analysed to identify genes that responded to OLE, following an eight-week intervention with 20 mL daily consumption of either OLE or PBO...
December 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27918197/educational-inequalities-in-mortality-of-patients-with-atrial-fibrillation-in-norway
#18
Rupali Akerkar, Marta Ebbing, Gerhard Sulo, Inger Ariansen, Jannicke Igland, Grethe S Tell, Grace M Egeland
OBJECTIVES: Socioeconomic gradients provide an indication of mortality's preventable fraction. Given the high mortality associated with atrial fibrillation (AF), we explored the educational gradient in all-cause and cardiovascular mortality in an AF patient population. DESIGN: We prospectively followed patients hospitalized with AF as primary discharge diagnosis. Patients were identified in a nationwide Cardiovascular Disease in Norway 2008-2012 project. The average length of follow-up was 2...
December 5, 2016: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/27916778/predictive-value-of-qrs-duration-at-admission-for-in-hospital-clinical-outcome-of-takotsubo-cardiomyopathy
#19
Tetsuo Yamaguchi, Tsutomu Yoshikawa, Toshiaki Isogai, Takamichi Miyamoto, Yuichiro Maekawa, Tetsuro Ueda, Konomi Sakata, Tsutomu Murakami, Takeshi Yamamoto, Ken Nagao, Morimasa Takayama
BACKGROUND: Prolonged QRS duration (pQRSd) on electrocardiogram (ECG) is a strong predictor of poor outcome in heart failure, myocardial infarction, and myocarditis, but it is unclear whether pQRSd also predicts poor outcomes of takotsubo cardiomyopathy (TC).Methods and Results:Between 1 January 2010 and 31 December 2012, we retrospectively enrolled 299 patients with TC (mean age, 73.5±11.7 years; 21.4% male) from the Tokyo CCU Network database, which consists of 71 cardiovascular centers in the metropolitan area...
December 2, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27916741/design-and-principle-of-operation-of-the-heartmate-phptm-percutaneous-heart-pump
#20
N M Van Mieghem, Joost Daemen, Corstiaan den Uil, Onur Dur, Linda Joziasse, AnneMarie Maugenest, Keif Fitzgerald, Chris Parker, Paul Muller, Robert-Jan van Geuns
The HeartMate PHP (Percutaneous Heart Pump) is a second-generation transcatheter axial flow circulatory support system. The collapsible catheter pump is inserted through a 14F sheath, deployed across the aortic valve expanding to 24F and able to deliver up to 5L/min blood flow at minimum hemolytic risk. As such this device may be a valuable adjunct to percutaneous coronary intervention (PCI) of challenging lesions in high-risk patients or treatment of cardiogenic shock. This technical report discusses: (i) the HeartMate PHP concept, (ii) the implantation technique, (iii) the hemodynamic performance in an in vitro cardiovascular flow testing setup and (iv) preliminary clinical experience...
December 6, 2016: EuroIntervention
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