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https://www.readbyqxmd.com/read/28719149/cadmium-induced-toxicity-is-rescued-by-curcumin-a-review
#1
REVIEW
Mohammad Mohajeri, Mehdi Rezaee, Amirhossein Sahebkar
Cadmium (Cd) is one of the most common environmental and occupational heavy metals with extended distribution. Exposure to Cd may be associated with several deleterious consequences on the liver, bones, kidneys, lungs, testes, brain, immunological, and cardiovascular systems. Overproduction of reactive oxygen species (ROS) as the main mechanism behind its toxicity causes oxidative stress and subsequent damages to lipids, proteins, and DNA. Therefore, antioxidants along with chelating agents have shown promising outcomes against Cd-induced toxicity...
July 18, 2017: BioFactors
https://www.readbyqxmd.com/read/28710641/a-ligand-binding-assay-to-measure-the-affinity-and-specificity-of-sterol-binding-proteins-in-vitro
#2
Rabih Darwiche, Roger Schneiter
Sterols are major constituents of the plasma membrane of eukaryotic cells and serve as a precursor for several classes of signaling molecules, including steroids and hydroxy sterols. They maintain the functionality and permeability barrier of the plasma membrane through lipid-lipid and lipid-protein interactions. The S. cerevisiae pathogen-related yeast proteins 1, 2, and 3 (Pry) belong to a large protein superfamily known as CAP/SCP/TAPS. Members of this superfamily have been implicated in a wide variety of processes, including immune defense in mammals and plants, pathogen virulence, sperm maturation and fertilization, venom toxicity, and prostate and brain cancer...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28708000/reactive-oxygen-species-and-mitochondrial-homeostasis-as-regulators-of-stem-cell-fate-and-function
#3
Darren Qiancheng Tan, Toshio Suda
SIGNIFICANCE: The precise role and impact of reactive oxygen species (ROS) in stem cells, which are essential for lifelong tissue homeostasis and regeneration, remains of significant interest to the field. The long-term regenerative potential of a stem cell compartment is determined by the delicate balance between quiescence, self-renewal and differentiation; all of which can be influenced by ROS levels. Recent advances: The past decade has seen a growing appreciation for the importance of ROS and redox homeostasis in various stem cell compartments; particularly those of hematopoietic, neural and muscle tissues...
July 14, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28692598/membrane-lipids-and-cell-signaling
#4
Hannah Sunshine, Maria Luisa Iruela-Arispe
PURPOSE OF REVIEW: Reception and transmission of signals across the plasma membrane has been a function generally attributed to transmembrane proteins. In the last 3 years, however, a growing number of reports have further acknowledged important contributions played by membrane lipids in the process of signal transduction. RECENT FINDINGS: In particular, the constituency of membrane lipids can regulate how proteins with SH2 domains and molecules like K-Ras expose their catalytic domains to the cytosol and interact with effectors and second messengers...
July 7, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28689077/atr-ir-study-of-skin-components-lipids-proteins-and-water-part-i-temperature-effect
#5
S Olsztyńska-Janus, A Pietruszka, Z Kiełbowicz, M A Czarnecki
In this work we report the studies of the effect of temperature on skin components, such as lipids, proteins and water. Modifications of lipids structure induced by increasing temperature (from 20 to 90°C) have been studied using ATR-IR (Attenuated Total Reflectance Infrared) spectroscopy, which is a powerful tool for characterization of the molecular structure and properties of tissues, such as skin. Due to the small depth of penetration (0.6-5.6μm), ATR-IR spectroscopy probes only the outermost layer of the skin, i...
July 4, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28676332/circulating-exosomes-in-obstructive-sleep-apnea-as-phenotypic-biomarkers-and-mechanistic-messengers-of-end-organ-morbidity
#6
REVIEW
Abdelnaby Khalyfa, Leila Kheirandish-Gozal, David Gozal
Obstructive sleep apnea (OSA), the most severe form of sleep disordered breathing, is characterized by intermittent hypoxia during sleep (IH), sleep fragmentation, and episodic hypercapnia. OSA is associated with increased risk for morbidity and mortality affecting cardiovascular, metabolic, and neurocognitive systems, and more recently with non-alcoholic fatty liver disease (NAFLD) and cancer-related deaths. Substantial variability in OSA outcomes suggests that genetically-determined and environmental and lifestyle factors affect the phenotypic susceptibility to OSA...
July 1, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28674187/pras40-connects-microenvironmental-stress-signaling-to-exosome-mediated-secretion
#7
Jiacong Guo, Priya Jayaprakash, Jian Dan, Petra Wise, Gyu-Beom Jang, Chengyu Liang, Mei Chen, David T Woodley, Muller Fabbri, Wei Li
Secreted exosomes carrying lipids, proteins and nucleic acids conduct cell-cell communications within the microenvironment of both physiological and pathological conditions. Exosome secretion is triggered by extracellular or intracellular stress signals. Little is known, however, about the signal transduction between stress cues and exosome secretion. To identify the linker protein, we took advantage of a unique finding in human keratinocytes. In these cells, although TGFα and EGF share the same EGF receptor and previously indistinguishable intracellular signaling networks, only TGFα stimulation causes exosome-mediated secretion...
July 3, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28671142/the-role-of-lipids-interacting-with-%C3%AE-synuclein-in-the-pathogenesis-of-parkinson-s-disease
#8
Céline Galvagnion
α-synuclein is a small protein abundantly expressed in the brain and located in synaptic terminals. The conversion of α-synuclein into oligomers and fibrils is the hallmark of a range of neurodegenerative disorders including Parkinson's disease and dementia with Lewy bodies. α-synuclein is disordered in solution but can adopt an α-helical conformation when bound to lipid membranes. This lipid-protein interaction plays an important role in its proposed biological function, i.e., synaptic plasticity, but can also entail the aggregation of the protein...
June 30, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28668220/modulation-of-protein-function-in-membrane-mimetics-characterization-of-p-denitrificans-cnor-in-nanodiscs-or-liposomes
#9
Josy Ter Beek, Maximilian Kahle, Pia Ädelroth
For detailed functional characterization, membrane proteins are usually studied in detergent. However, it is becoming clear that detergent micelles are often poor mimics of the lipid environment in which these proteins function. In this work we compared the catalytic properties of the membrane-embedded cytochrome c-dependent nitric oxide reductase (cNOR) from Paracoccus (P.) denitrificans in detergent, lipid/protein nanodiscs, and proteoliposomes. We used two different lipid mixtures, an extract of soybean lipids and a defined mix of synthetic lipids mimicking the original P...
June 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28660510/taurine-mitigates-nitrite-induced-methemoglobin-formation-and-oxidative-damage-in-human-erythrocytes
#10
Fariheen Aisha Ansari, Shaikh Nisar Ali, Riaz Mahmood
Nitrite is present as a noxious contaminant in drinking water and causes oxidative damage in various tissues of humans and animals. It is a well-known methemoglobin-forming agent that has been shown to damage blood cells. The protective effect of taurine, a semi-essential sulfur-containing amino acid, was studied on sodium nitrite (NaNO2)-induced oxidative damage in human erythrocytes. Erythrocytes were incubated with NaNO2, in the presence and absence of taurine, and changes in oxidative stress parameters determined...
June 28, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28657468/cooked-chickpea-consumption-inhibits-colon-carcinogenesis-in-mice-induced-with-azoxymethane-and-dextran-sulfate-sodium
#11
Xariss M Sánchez Chino, Cristian Jiménez Martínez, Verónica R Vásquez Garzón, Isela Álvarez González, Saúl Villa Treviño, Eduardo Madrigal Bujaidar, Gloria Dávila Ortiz, Rafael Baltiérrez Hoyos
SCOPE: The objective of the study was to evaluate the effect of daily consumption of cooked chickpea (2% and 10%) in ICR male mice in which colon cancer was induced with azoxymethane and dextran sulfate sodium. METHODS AND RESULTS: The effect of consumption of 2% or 10% cooked chickpeas on carcinogenesis-induced colon azoxymethane (AOM)/dextran sulfate sodium (DSS) in ICR mice was determined. Protein oxidation and lipids were determined by colorimetric methods and oxidation of DNA through the identification of adducts 8-hydroxy-2'-desoxiguanosine and proliferation markers (proliferating cell nuclear antigen [PCNA], Ki-67, and β-catenin), and inflammation (cyclooxygenase [COX]-2 and inducible nitric oxide synthase [iNOS]) were identified by immunohistochemistry reactions...
July 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28655600/cellular-mechanisms-of-peroxynitrite-induced-neuronal-death
#12
Kristina Ramdial, Maria Clara Franco, Alvaro G Estevez
Peroxynitrite (ONOO(-)) is a strong biological oxidant formed by the diffusion-limited reaction of nitric oxide (NO(-)) and superoxide anion (O2(-)). It has long been theorized that peroxynitrite generation could be the cause in a number of pathological conditions ranging from atherosclerosis to inflammatory, autoimmune, heart and neurodegenerative diseases. Its relatively long biological half-life and high reactivity allows peroxynitrite to oxidize a number of different targets in the cell. In physiologically relevant conditions peroxynitrite can directly react with thiols, or the radical products of peroxynitrite decomposition may indirectly oxidize other cellular components such as lipids, proteins and DNA...
June 24, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28638081/development-of-lysosome-mimicking-vesicles-to-study-the-effect-of-abnormal-accumulation-of-sphingosine-on-membrane-properties
#13
Ana C Carreira, Rodrigo F M de Almeida, Liana C Silva
Synthetic systems are widely used to unveil the molecular mechanisms of complex cellular events. Artificial membranes are key examples of models employed to address lipid-lipid and lipid-protein interactions. In this work, we developed a new synthetic system that more closely resembles the lysosome - the lysosome-mimicking vesicles (LMVs) - displaying stable acid-to-neutral pH gradient across the membrane. To evaluate the advantages of this synthetic system, we assessed the distinct effects of sphingosine (Sph) accumulation in membrane structure and biophysical properties of standard liposomes (no pH gradient) and in LMVs with lipid composition tuned to mimic physiological- or NPC1-like lysosomes...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630155/haemolytic-actinoporins-interact-with-carbohydrates-using-their-lipid-binding-module
#14
Koji Tanaka, Jose M M Caaveiro, Koldo Morante, Kouhei Tsumoto
Pore-forming toxins (PFTs) are proteins endowed with metamorphic properties that enable them to stably fold in water solutions as well as in cellular membranes. PFTs produce lytic pores on the plasma membranes of target cells conducive to lesions, playing key roles in the defensive and offensive molecular systems of living organisms. Actinoporins are a family of potent haemolytic toxins produced by sea anemones vigorously studied as a paradigm of α-helical PFTs, in the context of lipid-protein interactions, and in connection with nanopore technologies...
August 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28629723/microbial-antioxidant-defense-enzymes
#15
REVIEW
Cindy Staerck, Amandine Gastebois, Patrick Vandeputte, Alphonse Calenda, Gérald Larcher, Louiza Gillmann, Nicolas Papon, Jean-Philippe Bouchara, Maxime J J Fleury
Free radicals are often described as chemical compounds characterized by unpaired electrons in their outer orbital rendering them highly reactive species. In mammalians, studies on free radicals were focused on reactive oxygen species (ROS) or reactive nitrogen species (RNS) due to their relative importance in physiological as well as in pathological processes. These cellular compounds are produced by different physiological systems such as the aerobic metabolism and play a major role in cell signaling pathways but also in the host immune defenses against pathogenic microorganisms...
June 16, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28624493/expression-of-the-c-terminal-domain-of-human-apolipoprotein-a-i-using-a-chimeric-apolipoprotein
#16
Daniel E Sallee, James V C Horn, Lukas A Fuentes, Paul M M Weers
Human apolipoprotein A-I (apoA-I) is the most abundant protein in high-density lipoprotein, an anti-atherogenic lipid-protein complex responsible for reverse cholesterol transport. The protein is composed of an N-terminal helix bundle domain, and a small C-terminal (CT) domain. To facilitate study of CT-apoA-I, a novel strategy was employed to produce this small domain in a bacterial expression system. A protein construct was designed of insect apolipophorin III (apoLp-III) and residues 179-243 of apoA-I, with a unique methionine residue positioned between the two proteins and an N-terminal His-tag to facilitate purification...
June 15, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28619676/peroxynitrite-modified-histone-as-a-pathophysiological-biomarker-in-autoimmune-diseases
#17
REVIEW
Md Asad Khan, Khursheed Alam, Md Zafaryab, M Moshahid A Rizvi
Under physiological conditions, reactive nitrogen and oxygen species are produced continuously. However, excess of these radicals may damage biomolecules like lipids, proteins and nucleic acids. These reactive species have been implicated in many disease conditions including acute/chronic inflammation, rheumatoid arthritis (RA), neurodegenerative diseases and systemic lupus erythematosus (SLE). Peroxynitrite, an oxidant and nitrating molecule, formed in in vivo, when nitric oxide reacts with superoxide radical...
June 12, 2017: Biochimie
https://www.readbyqxmd.com/read/28613917/microwave-processing-effects-and-impacts-on-food-components
#18
Hao Jiang, Zhigang Liu, Shaojin Wang
As an efficient heating method, microwave processing has attracted attentions both in academic research and industry. However, the mechanism of dielectric heating is quite distinct from that of the traditional conduction heating, and is widely applied as polar-molecules and charged ions interaction with the alternative electromagnetic fields, resulting in fast and volumetric heating through their frication losses. Such a heating pattern would cause a certain change in microwave treatment, which is unarguable reality...
June 14, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28605725/a-general-reaction-network-and-kinetic-model-of-the-hydrothermal-liquefaction-of-microalgae-tetraselmis-sp
#19
The Ky Vo, Seung-Soo Kim, Hoang Vu Ly, Eun Yeol Lee, Choul-Gyun Lee, Jinsoo Kim
In this work, the hydrothermal liquefaction (HTL) of microalgal Tetraselmis sp. was conducted at various reaction temperatures (250-350°C) and reaction times (10-60min). A general reaction network and a quantitative kinetic model were proposed for the HTL of microalgae. In this reaction network, the primary decomposition of lipids, proteins, and carbohydrates generated heavy oil (HO), light oil (LO), and aqueous-phase (AP) products. Then, reversible interconversions and further decomposition of these product fractions to produce gas product were followed...
October 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28601647/metalloproteomic-and-differential-expression-in-plasma-in-a-rat-model-of-type-1-diabetes
#20
Camila Pereira Braga, José Cavalcante Souza Vieira, Aline de Lima Leite, Ana Angélica Henrique Fernandes, Marília Afonso Rabelo Buzalaf, Pedro de Magalhães Padilha
Type 1 diabetes is characterized by hyperglycemia, which in the chronic stage is associated with abnormalities in lipids, protein and, carbohydrate metabolism, as well as oxidative stress. New strategies for prevention and treatment are needed, as type 1 diabetes affects life quality and survival, and involves high-cost treatment. Proteomic and metalloproteomic studies can elucidate the functional and physiological aspects of biomolecules. In the present study, differential proteomics was used to identify potential biomarkers of diabetes in rat plasma associated with copper, selenium, zinc, and magnesium fractionation in control and diabetic rats, as well as diabetic rats treated with insulin...
June 8, 2017: International Journal of Biological Macromolecules
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