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https://www.readbyqxmd.com/read/28936751/guidelines-versus-real-life-practice-the-case-of-colonoscopy-in-acromegaly
#1
M Parolin, F Dassie, L Russo, S Mazzocut, M Ferrata, E De Carlo, R Mioni, F Fallo, R Vettor, C Martini, P Maffei
PURPOSE: The aim of this study is to investigate guideline application and colonoscopy findings in real-life practice in acromegaly. METHODS: We conducted a retrospective observational non-interventional and cross-sectional analysis on 146 patients with acromegaly (ACRO) referred to our clinic. We evaluated colonoscopy data, focusing on the correlation between colonoscopy findings and hormonal/metabolic values. RESULTS: The total number of colonoscopies performed in ACRO patients increased from 6 in the period 1990-1994 to 57 in the period 2010-2014...
September 21, 2017: Pituitary
https://www.readbyqxmd.com/read/28935221/thermal-stability-of-mafenide-and-amphotericin-b-topical-solution
#2
Julie A Rizzo, Angela K Martini, Kaitlin A Pruskowski, Matthew P Rowan, Krista L Niece, Kevin S Akers
OBJECTIVE: Fungal infections remain a major cause of mortality in the burned population. Mafenide acetate/amphotericin B solution (SMAT) has been used topically for prophylaxis and treatment of these infections. Current manufacturer guidelines only guarantee the stability of mafenide solution and amphotericin B at room temperature. Additionally, the recommended maximum storage time for mafenide solution is 48h, leading to significant financial and material loss when unused solutions are discarded...
September 18, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28934353/correction-coenzyme-q10-plus-multivitamin-treatment-prevents-cisplatin-ototoxicity-in-rats
#3
Laura Astolfi, Edi Simoni, Filippo Valente, Sara Ghiselli, Stavros Hatzopoulos, Milvia Chicca, Alessandro Martini
[This corrects the article DOI: 10.1371/journal.pone.0162106.].
2017: PloS One
https://www.readbyqxmd.com/read/28934352/global-reaction-to-the-recent-outbreaks-of-zika-virus-insights-from-a-big-data-analysis
#4
Nicola Luigi Bragazzi, Cristiano Alicino, Cecilia Trucchi, Chiara Paganino, Ilaria Barberis, Mariano Martini, Laura Sticchi, Eugen Trinka, Francesco Brigo, Filippo Ansaldi, Giancarlo Icardi, Andrea Orsi
OBJECTIVE: The recent spreading of Zika virus represents an emerging global health threat. As such, it is attracting public interest worldwide, generating a great amount of related Internet searches and social media interactions. The aim of this research was to understand Zika-related digital behavior throughout the epidemic spreading and to assess its consistence with real-world epidemiological data, using a behavioral informatics and analytics approach. METHODS: In this study, the global web-interest and reaction to the recently occurred outbreaks of the Zika Virus were analyzed in terms of tweets and Google Trends (GT), Google News, YouTube, and Wikipedia search queries...
2017: PloS One
https://www.readbyqxmd.com/read/28931313/muscle-expression-of-sod1g93a-triggers-the-dismantlement-of-neuromuscular-junction-via-pkc-theta
#5
Gabriella Dobrowolny, Martina Martini, Bianca Maria Scicchitano, Vanina Romanello, Simona Boncompagni, Carmine Nicoletti, Laura Pietrangelo, Simone De Panfilis, Angela Catizone, Marina Bouche, Marco Sandri, Rudiger Rudolf, Feliciano Protasi, Antonio Musaro
Aim Neuromuscular junction (NMJ) represents the morpho-functional interface between muscle and nerve. Several chronic pathologies such as aging and neurodegenerative diseases, including muscular dystrophy and Amyotrophic Lateral Sclerosis (ALS), display altered NMJ and functional denervation. However, the triggers and the molecular mechanisms underlying the dismantlement of NMJ remain unclear. Results Here we provide evidence that perturbation in redox signaling cascades, induced by muscle-specific accumulation of mutant SOD1G93A in transgenic MLC/SOD1G93A mice, is causally linked to morphological alterations of the neuromuscular presynaptic terminals, high turnover rate of Acetylcholine Receptor (AChR), and NMJ dismantlement...
September 20, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28928741/cxcl12-mediates-aberrant-costimulation-of-b-lymphocytes-in-warts-hypogammaglobulinemia-infections-myelokathexis-immunodeficiency
#6
Giuliana Roselli, Elisa Martini, Vassilios Lougaris, Raffaele Badolato, Antonella Viola, Marinos Kallikourdis
The Warts, Hypogammaglobulinemia, Infections, Myelokathexis (WHIM) syndrome is an immunodeficiency caused by mutations in chemokine receptor CXCR4. WHIM patient adaptive immunity defects remain largely unexplained. We have previously shown that WHIM-mutant T cells form unstable immunological synapses, affecting T cell activation. Here, we show that, in WHIM patients and WHIM CXCR4 knock-in mice, B cells are more apoptosis prone. Intriguingly, WHIM-mutant B cells were also characterized by spontaneous activation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28921985/computer-aided-identification-and-lead-optimization-of-dual-murine-double-minute-2-and-4-binders-structure-activity-relationship-studies-and-pharmacological-activity
#7
Mariateresa Giustiniano, Simona Daniele, Sveva Pelliccia, Valeria La Pietra, Deborah Pietrobono, Diego Brancaccio, Sandro Cosconati, Anna Messere, Stefano Giuntini, Linda Cerofolini, Marco Fragai, Claudio Luchinat, Sabrina Taliani, Giuseppe La Regina, Federico Da Settimo, Romano Silvestri, Claudia Martini, Ettore Novellino, Luciana Marinelli
The function of p53 protein, also known as "genome guardian", might be impaired by the over-expression of its primary cellular inhibitor, the murine double minute 2 protein (MDM2). However, the recent finding that MDM2-selective inhibitors induce high levels of its homolog MDM4, prompt us to identify, through a receptor-based virtual screening on an in house dababase, dual MDM2/MDM4 binders. Compound 1 turned out to possess an IC50 of 93.7 nM and of 4.6 nM on MDM2 and MDM4 respectively. A series of compounds were synthetized to optimize its activity on MDM2...
September 18, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28921807/the-italian-compassionate-use-of-sofosbuvir-in-hcv-patients-waitlisted-for-liver-transplantation-a-national-real-life-experience
#8
Silvia Martini, Maria Francesca Donato, Chiara Mazzarelli, Maria Rendina, Ubaldo Visco-Comandini, Daniela Filì, Alice Gianstefani, Stefano Fagiuoli, Mario Melazzini, Simona Montilla, Luca Pani, Sandra Petraglia, Pierluigi Russo, Maria Paola Trotta, Paola Carrai, Paolo Caraceni
BACKGROUND & AIMS: This study aimed to assess the real-life clinical and virological outcomes of HCV waitlisted patients for liver transplantation (LT) who received sofosbuvir/ribavirin (SOF/R) within the Italian compassionate use program. METHODS: Clinical and virological data were collected in 224 patients with decompensated cirrhosis and/or hepatocellular carcinoma (HCC) receiving daily SOF/R until LT or up a maximum of 48 weeks. RESULTS: Of 100 transplanted patients, 51 were HCV-RNA negative for >4 weeks before LT (SVR12: 88%) and 49 negative for <4 weeks or still viremic at transplant: 34 patients continued treatment after LT (bridging therapy) (SVR12: 88%), while 15 stopped treatment (SVR12: 53%)...
September 16, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28917643/a-novel-3-dimensional-electromagnetic-guidance-system-increases-intraoperative-microwave-antenna-placement-accuracy
#9
Amit V Sastry, Jacob H Swet, Keith J Murphy, Erin H Baker, Dionisios Vrochides, John B Martinie, Iain H McKillop, David A Iannitti
BACKGROUND: Failure to locate lesions and accurately place microwave antennas can lead to incomplete tumor ablation. The Emprint™ SX Ablation Platform employs real-time 3D-electromagnetic spatial antenna tracking to generate intraoperative laparoscopic antenna guidance. We sought to determine whether Emprint™ SX affected time/accuracy of antenna-placement in a laparoscopic training model. METHODS: Targets (7-10 mm) were set in agar within a laparoscopic training device...
September 13, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28917526/who-makes-the-best-martini
#10
EDITORIAL
Jonathan M Chen
No abstract text is available yet for this article.
September 13, 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28916543/cryopyrin-associated-periodic-syndromes-in-italian-patients-evaluation-of-the-rate-of-somatic-nlrp3-mosaicism-and-phenotypic-characterization
#11
Denise Lasigliè, Anna Mensa-Vilaro, Denise Ferrera, Roberta Caorsi, Federica Penco, Giuseppe Santamaria, Marco Di Duca, Giulia Amico, Kenji Nakagawa, Francesca Antonini, Alberto Tommasini, Rita Consolini, Antonella Insalaco, Marco Cattalini, Laura Obici, Romina Gallizzi, Francesca Santarelli, Genny Del Zotto, Mariasavina Severino, Anna Rubartelli, Roberto Ravazzolo, Alberto Martini, Isabella Ceccherini, Ryuta Nishikomori, Marco Gattorno, Juan I Arostegui, Silvia Borghini
OBJECTIVE: To evaluate the rate of somatic NLRP3 mosaicism in an Italian cohort of mutation-negative patients with cryopyrin-associated periodic syndrome (CAPS). METHODS: The study enrolled 14 patients with a clinical phenotype consistent with CAPS in whom Sanger sequencing of the NLRP3 gene yielded negative results. Patients' DNA were subjected to amplicon-based NLRP3 deep sequencing. RESULTS: Low-level somatic NLRP3 mosaicism has been detected in 4 patients, 3 affected with chronic infantile neurological cutaneous and articular syndrome and 1 with Muckle-Wells syndrome...
September 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28916018/essential-elements-of-a-collaborative-mental-health-training-program-for-primary-care
#12
REVIEW
Lisa L Giles, D Richard Martini
Mental health integration in primary care is based on creating an environment that encourages collaboration and supports appropriate care for patients and families while offering a full range of services. Training programs for primary care practitioners should include sessions on how to build and maintain such a practice along with information on basic mental health competencies.
October 2017: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28913904/re-emergence-of-rabies-virus-maintained-by-canid-populations-in-paraguay
#13
A C F Amarilla, J C A Pompei, D B Araujo, F A Vázquez, R R Galeano, L M Delgado, G Bogado, M Colman, L Sanabria, K Iamamoto, R Garcia, D Assis, R Recalde, L F Martorelli, E Quiñones, A Cabello, M Martini, O Cosivi, E L Durigon, S R Favoretto
Paraguay has registered no human cases of rabies since 2004, and the last case in dogs, reported in 2009, was due to a variant maintained in the common vampire bat "Desmodus rotundus". In 2014, a dog was diagnosed as positive for rabies with aggression towards a boy and all required measures of control were successfully adopted. Epidemiological investigation revealed that the dog was not vaccinated and had been attacked by a crab-eating fox, "zorro" (Cerdocyon thous). The sample was diagnosed by the Official Veterinary Service of the Country and sent to the Center on Rabies Research from the University of São Paulo, Brazil, for antigenic and genetic characterization...
September 14, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28912442/the-association-between-respiratory-tract-infection-incidence-and-localised-meningitis-epidemics-an-analysis-of-high-resolution-surveillance-data-from-burkina-faso
#14
Judith E Mueller, Maxime Woringer, Souleymane Porgho, Yoann Madec, Haoua Tall, Nadège Martiny, Brice W Bicaba
Meningococcal meningitis epidemics in the African meningitis belt consist of localised meningitis epidemics (LME) that reach attack proportions of 1% within a few weeks. A meningococcal serogroup A conjugate vaccine was introduced in meningitis belt countries from 2010 on, but LME due to other serogroups continue to occur. The mechanisms underlying LME are poorly understood, but an association with respiratory pathogens has been hypothesised. We analysed national routine surveillance data in high spatial resolution (health centre level) from 13 districts in Burkina Faso, 2004-2014...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912427/dna-methylation-profiling-reveals-common-signatures-of-tumorigenesis-and-defines-epigenetic-prognostic-subtypes-of-canine-diffuse-large-b-cell-lymphoma
#15
Serena Ferraresso, Arianna Aricò, Tiziana Sanavia, Silvia Da Ros, Massimo Milan, Luciano Cascione, Stefano Comazzi, Valeria Martini, Mery Giantin, Barbara Di Camillo, Sandro Mazzariol, Diana Giannuzzi, Laura Marconato, Luca Aresu
Epigenetic deregulation is a hallmark of cancer characterized by frequent acquisition of new DNA methylation in CpG islands. To gain insight into the methylation changes of canine DLBCL, we investigated the DNA methylome in primary DLBCLs in comparison with control lymph nodes by genome-wide CpG microarray. We identified 1,194 target loci showing different methylation levels in tumors compared with controls. The hypermethylated CpG loci included promoter, 5'-UTRs, upstream and exonic regions. Interestingly, targets of polycomb repressive complex in stem cells were mostly affected suggesting that DLBCL shares a stem cell-like epigenetic pattern...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911888/postoperative-imaging-of-orthopaedic-hardware-in-the-hand-and-wrist-is-there-an-added-value-for-tomosynthesis
#16
A De Silvestro, K Martini, A S Becker, T D L Kim-Nguyen, R Guggenberger, M Calcagni, T Frauenfelder
AIM: To prospectively investigate digital tomosynthesis (DTS) as an alternative to digital radiography (DR) for postoperative imaging of orthopaedic hardware after trauma or arthrodesis in the hand and wrist. MATERIALS AND METHODS: Thirty-six consecutive patients (12 female, median age 36 years, range 19-86 years) were included in this institutional review board approved clinical trial. Imaging was performed with DTS in dorso-palmar projection and DR was performed in dorso-palmar, lateral, and oblique views...
September 11, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28906572/culex-torrentium-mosquitoes-from-germany-are-negative-for-wolbachia
#17
M Leggewie, R Krumkamp, M Badusche, A Heitmann, S Jansen, J Schmidt-Chanasit, E Tannich, S C Becker
Wolbachia (Rickettsiales: Anaplasmataceae) infects a wide range of arthropods, including several mosquito species. The bacterium is known to induce a plethora of phenotypes in its host, examples being the reproductive phenotype cytoplasmic incompatibility or resistance against infection with arboviruses. The latter is especially relevant when assessing the vector competence of mosquito species for emerging arboviruses. Thus, knowledge of Wolbachia infection status is important for the assessment of vector competence...
September 14, 2017: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/28905203/adaptive-resolution-simulations-of-biomolecular-systems
#18
Julija Zavadlav, Staš Bevc, Matej Praprotnik
In this review article, we discuss and analyze some recently developed hybrid atomistic-mesoscopic solvent models for multiscale biomolecular simulations. We focus on the biomolecular applications of the adaptive resolution scheme (AdResS), which allows solvent molecules to change their resolution back and forth between atomistic and coarse-grained representations according to their positions in the system. First, we discuss coupling of atomistic and coarse-grained models of salt solution using a 1-to-1 molecular mapping-i...
September 13, 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/28904383/effects-of-coarse-graining-and-saturation-of-hydrocarbon-chains-on-structure-and-dynamics-of-simulated-lipid-molecules
#19
Pavel Buslaev, Ivan Gushchin
Molecular dynamics simulations are used extensively to study the processes on biological membranes. The simulations can be conducted at different levels of resolution: all atom (AA), where all atomistic details are provided; united atom (UA), where hydrogen atoms are treated inseparably of corresponding heavy atoms; and coarse grained (CG), where atoms are grouped into larger particles. Here, we study the behavior of model bilayers consisting of saturated and unsaturated lipids DOPC, SOPC, OSPC and DSPC in simulations performed using all atom CHARMM36 and coarse grained Martini force fields...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28901318/surgical-treatment-is-an-effective-approach-for-patients-with-synchronous-multiple-primary-lung-cancers
#20
Yue Peng, Wangang Ren, Hui Wang, Meng Li, Zhen Feng, Zhongmin Peng
OBJECTIVE: The detection rate of synchronous multiple primary lung cancers (SMPLC) showed an increasing trend year by year. In an attempt to identify the optimal treatment strategy for SMPLC, we retrospectively analyzed our surgical treatment outcomes of a series of patients with SMPLC. MATERIALS AND METHODS: A total of 43 SMPLC patients who met the modified Martini-Melamed criteria and with clinical data retained between November 2012 and July 2016 underwent complete resection without any preoperative induction therapy at the Department of Thoracic Surgery, Shandong Provincial Hospital...
2017: Journal of Cancer Research and Therapeutics
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