Gloria Vaghi, Andrea Morotti, Elisa Maria Piella, Micol Avenali, Daniele Martinelli, Silvano Cristina, Marta Allena, Valentina Grillo, Michele Corrado, Federico Bighiani, Francescantonio Cammarota, Alessandro Antoniazzi, Federica Ferrari, Federico Mazzacane, Anna Cavallini, Anna Pichiecchio, Elisa Rognone, Luca Martinis, Luca Correale, Stefano Filippo Castiglia, Dante Trabassi, Mariano Serrao, Cristina Tassorelli, Roberto De Icco
Stroke affects the interconnection between the nervous and immune systems, leading to a down-regulation of immunity called stroke-induced immunosuppression (SII). The primary aim of this study is to investigate SII role as a predictor of functional, neurological, and motor outcomes in the neurorehabilitation setting (NRB). We conducted a prospective observational study enrolling post-acute stroke patients hospitalized for neurorehabilitation. At NRB admission (T0 ) and discharge (T1 ), we assessed presence of SII (defined by a neutrophil-to-lymphocyte ratio ≥ 5) and we evaluated functional independence (Functional Independence Measure-FIM, Barthel Index-BI), motor performances (Tinetti Score, Hauser Ambulation Index) and neurological impairment (NIHSS)...
April 9, 2024: Scientific Reports