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https://www.readbyqxmd.com/read/28637044/depressed-patients-hospitalized-in-southeast-facing-rooms-are-discharged-earlier-than-patients-in-northwest-facing-rooms
#1
Krzysztof Gbyl, Helle Østergaard Madsen, Signe Dunker Svendsen, Paul Michael Petersen, Ida Hageman, Carlo Volf, Klaus Martiny
BACKGROUND AND AIM: Improvement in patients admitted to inpatient wards with severe depression is slow, and such patients are often discharged with residual symptoms which put them at risk for relapse. New treatments that can speed up recovery are highly desired. This naturalistic follow-up study in a specialized affective disorders unit investigated the impact of daylight on the length of hospital stay and improvement of depression. METHODS: For a period of 1 year, we collected data on sociodemographics, length of stay, vitamin D, and depression severity for patients in an inpatient affective disorders unit...
June 22, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28635340/from-seed-to-cooked-pasta-influence-of-traditional-and-non-conventional-transformation-processes-on-total-antioxidant-capacity-and-phenolic-acid-content
#2
Daniela Martini, Roberto Ciccoritti, Isabella Nicoletti, Francesca Nocente, Danilo Corradini, Maria Grazia D'Egidio, Federica Taddei
The aim of this work was to compare the traditional with a non-conventional (i.e. kernel micronisation) durum wheat milling process by monitoring the content of bound, conjugated and free phenolic acids (PAs) and the level of the total antioxidant capacity (TAC) occurring in the durum wheat pasta production chain, from seed to cooked pasta. The traditional transformation processes negatively influenced TAC and PA content (40% and 89% decrease from seed to cooked pasta, respectively), mainly during the milling process (25% and 84% decrease of TAC and PA, respectively), which has been related to the removal of external layers of kernels...
June 21, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28633759/martini-coarse-grained-force-field-extension-to-rna
#3
Jaakko J Uusitalo, Helgi I Ingólfsson, Siewert J Marrink, Ignacio Faustino
RNA has an important role not only as the messenger of genetic information but also as a regulator of gene expression. Given its central role in cell biology, there is significant interest in studying the structural and dynamic behavior of RNA in relation to other biomolecules. Coarse-grain molecular dynamics simulations are a key tool to that end. Here, we have extended the coarse-grain Martini force field to include RNA after our recent extension to DNA. In the same way DNA was modeled, the tertiary structure of RNA is constrained using an elastic network...
June 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28624621/innate-immune-system-capabilities-of-the-asian-citrus-psyllid-diaphorina-citri
#4
Alex Arp, Xavier Martini, Kirsten Pelz-Stelinski
Citrus production worldwide is currently threatened by Huanglongbing, or citrus greening disease. The associated pathogen, Candidatus Liberibacter asiaticus (CLas), is transmitted by the Asian citrus psyllid, Diaphorina citri. Annotation of the D. citri genome revealed a reduced innate immune system lacking a number of antimicrobial peptides and the Imd pathway associated with defense against Gram-negative bacteria. We characterized this apparent immune reduction in survival assays in which D. citri were exposed to Gram-negative or Gram-positive bacteria...
June 14, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28623808/role-of-polyphenols-and-polyphenol-rich-foods-in-the-modulation-of-pon1-activity-and-expression
#5
REVIEW
Daniela Martini, Cristian Del Bo', Marisa Porrini, Salvatore Ciappellano, Patrizia Riso
Paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme involved in the protection of low-density lipoprotein and HDLs against lipid peroxidation. Several studies documented the capacity of polyphenols to stimulate PON1 transcription activation. The objective of the present review is to provide the main evidence about the role and the potential mechanism of action of polyphenols and polyphenol-rich foods in the modulation of PON1 gene expression and activity. A total of 76 in vitro and in vivo studies were included in the review...
June 6, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28623651/an-investigation-of-support-services-available-by-internet-searching-to-families-impacted-by-a-parent-s-cancer
#6
Ms Julia Morris, Jeneva Ohan, Angelita Martini
OBJECTIVE: Throughout a parent's cancer diagnosis and treatment, families are likely to turn to the Internet to find social, emotional and informational support services. It is important professionals understand the content and availability of support discoverable through web searches. This study identified and described web-based information regarding support services offered to families when a parent has cancer. METHODS: Pre-defined key search terms were searched across two public web browsers for a period of 3 months...
June 16, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28623550/antibiotic-susceptibility-profiles-among-campylobacter-isolates-obtained-from-international-travelers-between-2007-and-2014
#7
A Post, D Martiny, N van Waterschoot, M Hallin, U Maniewski, E Bottieau, M Van Esbroeck, E Vlieghe, S Ombelet, O Vandenberg, J Jacobs
Campylobacter infection is a common cause of diarrhea among international travelers. We studied antibiotic resistance patterns among Campylobacter isolates obtained from international travelers according to travel destination. Three collections of isolates obtained from international travelers between 2007 and 2014 (Institute of Tropical Medicine, the "Laboratoire Hospitalier Universitaire de Bruxelles "and the Belgian National Reference Centre for Campylobacter) were used. Isolates were tested for minimal inhibitory concentration (MIC) values (E-test macromethod) for fluoroquinolones, macrolides, tetracyclines, amoxicillin-clavulanic acid, and meropenem...
June 17, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28622579/evidence-of-promising-biological-pharmacological-activities-of-the-sertraline-based-copper-complex-serh2-2-cucl4
#8
Nancy Martini, Juliana E Parente, Maria Eugenia Toledo, Graciela E Escudero, Carlos H Laino, Juan José Martínez Medina, Gustavo A Echeverría, Oscar E Piro, Luis Lezama, Patricia A M Williams, Evelina G Ferrer
In the current study the ability of copper complex to exert multiple biological activities is combined with the pharmacological action of sertraline (SerH2Cl, antidepressant drug). The hydrated and anhydrous forms of the tetrachlorocuprate(II) salts, namely (SerH2)2[CuCl4]·½H2O and (SerH2)2[CuCl4], were synthesized and characterized by physicochemical methods. The crystal structures were determined by X-ray diffraction methods. The hydrate complex crystallizes in the monoclinic P21 space group with a=8.0807(2) Å, b=36...
June 1, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28621706/nada-ear-acupuncture-an-adjunctive-therapy-to-improve-and-maintain-positive-outcomes-in-substance-abuse-treatment
#9
Kenneth Carter, Michelle Olshan-Perlmutter, Jonathan Marx, Janet F Martini, Simon B Cairns
The National Acupuncture Detoxification Association protocol (NADA) is an adjunctive therapy using 1 to 5 invariant ear acupuncture/acupressure points. This is a randomized prospective study to determine if NADA plus traditional treatment enhance outcomes: quality of life, depression, anxiety and abstinence from substance abuse. There were 100 patients enrolled in the Keystone Substance Abuse Services-Winthrop University Department of Sociology and Anthropology NADA study. All patients completed Generalized Anxiety Disorder scale (GAD-7), Patient Health Questionnaire (PHQ-9), Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES) prior to starting the program and at program completion...
June 16, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28619114/reducing-the-rate-and-duration-of-re-admissions-among-patients-with-unipolar-disorder-and-bipolar-disorder-using-smartphone-based-monitoring-and-treatment-the-radmis-trials-study-protocol-for-two-randomized-controlled-trials
#10
Maria Faurholt-Jepsen, Mads Frost, Klaus Martiny, Nanna Tuxen, Nicole Rosenberg, Jonas Busk, Ole Winther, Jakob Eyvind Bardram, Lars Vedel Kessing
BACKGROUND: Unipolar and bipolar disorder combined account for nearly half of all morbidity and mortality due to mental and substance use disorders, and burden society with the highest health care costs of all psychiatric and neurological disorders. Among these, costs due to psychiatric hospitalization are a major burden. Smartphones comprise an innovative and unique platform for the monitoring and treatment of depression and mania. No prior trial has investigated whether the use of a smartphone-based system can prevent re-admission among patients discharged from hospital...
June 15, 2017: Trials
https://www.readbyqxmd.com/read/28617899/when-somatic-mutations-are-associated-with-a-higher-aggressive-behavior-a-story-of-announced-evidence
#11
Esther Diana Rossi, Maurizio Martini, Luigi Maria Larocca
No abstract text is available yet for this article.
June 15, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28614722/quantitative-analysis-of-the-dna-methylation-sensitivity-of-transcription-factor-complexes
#12
Judith F Kribelbauer, Oleg Laptenko, Siying Chen, Gabriella D Martini, William A Freed-Pastor, Carol Prives, Richard S Mann, Harmen J Bussemaker
Although DNA modifications play an important role in gene regulation, the underlying mechanisms remain elusive. We developed EpiSELEX-seq to probe the sensitivity of transcription factor binding to DNA modification in vitro using massively parallel sequencing. Feature-based modeling quantifies the effect of cytosine methylation ((5)mC) on binding free energy in a position-specific manner. Application to the human bZIP proteins ATF4 and C/EBPβ and three different Pbx-Hox complexes shows that (5)mCpG can both increase and decrease affinity, depending on where the modification occurs within the protein-DNA interface...
June 13, 2017: Cell Reports
https://www.readbyqxmd.com/read/28613904/-martinizing-the-variational-implicit-solvent-method-vism-solvation-free-energy-for-coarse-grained-proteins
#13
Clarisse Gravina Ricci, Bo Li, Li-Tien Cheng, Joachim Dzubiella, J Andrew McCammon
Solvation is a fundamental driving force in many biological processes including biomolecular recognition and self-assembly, not to mention protein folding, dynamics, and function. The Variational Implicit Solvent Method (VISM) is a theoretical tool currently developed and optimized to estimate solvation free energies for systems of very complex topology, such as biomolecules. VISM's theoretical framework makes it unique because it couples hydrophobic, van der Waals and electrostatic interactions as a functional of the solvation interface...
June 14, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28611621/whole-body-awareness-for-controlling-a-robotic-transfemoral-prosthesis
#14
Andrea Parri, Elena Martini, Joost Geeroms, Louis Flynn, Guido Pasquini, Simona Crea, Raffaele Molino Lova, Dirk Lefeber, Roman Kamnik, Marko Munih, Nicola Vitiello
Restoring locomotion functionality of transfemoral amputees is essential for early rehabilitation treatment and for preserving mobility and independence in daily life. Research in wearable robotics fostered the development of innovative active mechatronic lower-limb prostheses designed with the goal to reduce the cognitive and physical effort of lower-limb amputees in rehabilitation and daily life activities. To ensure benefits to the users, active mechatronic prostheses are expected to be aware of the user intention and properly interact in a closed human-in-the-loop paradigm...
2017: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/28610983/design-and-synthesis-of-a-novel-inhibitor-of-t-viride-chitinase-through-an-in-silico-target-fishing-protocol
#15
Giorgio Maccari, Davide Deodato, Diego Fiorucci, Francesco Orofino, Giuseppina I Truglio, Carolina Pasero, Riccardo Martini, Filomena De Luca, Jean-Denis Docquier, Maurizio Botta
In the last ten years, we identified and developed a new therapeutic class of antifungal agents, the macrocyclic amidinoureas. These compounds are active against several Candida species, including clinical isolates resistant to currently available antifungal drugs. The mode of action of these molecules is still unknown. In this work, we developed an in-silico target fishing procedure to identify a possible target for this class of compounds based on shape similarity, inverse docking procedure and consensus score rank-by-rank...
June 10, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28609792/-systematic-review-on-conservative-treatment-options-in-non-muscle-invasive-bladder-cancer-patients-refractory-to-bacillus-calmette-gu%C3%A3-rin-instillation-therapy
#16
Thomas Martini, Felix Wezel, Niklas Löbig, Michael J Mitterberger, Daniela Colleselli
Background Adjuvant Bacillus Calmette-Guérin (BCG) intravesical instillation is the recommended standard treatment in patients with high-risk non-muscle-invasive bladder cancer (NMIBC). However, a significant proportion of patients fail treatment, and radical cystectomy (RC) is the subsequent gold standard. On the other hand, there is an unmet need for conservative alternatives for patients who are unfit or unwilling to undergo surgery. This study aimed to identify conservative treatment options in NMIBC patients after BCG failure...
June 13, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28598321/reply-to-about-the-airtrip-randomised-clinical-trial
#17
Antonio Brucato, Massimo Imazio, Marco Gattorno, Silvia Maestroni, Alberto Martini
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May 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28595084/identification-of-peripheral-blood-involvement-in-dogs-with-large-b-cell-lymphoma-comparison-of-different-methods
#18
Fulvio Riondato, Valeria Martini, Alessia Poggi, Ilaria Massaglia, Stefano Comazzi, Antonio Borrelli, Barbara Miniscalco
Stage V lymphoma is defined as the presence of neoplastic cells in peripheral blood (PB), bone marrow, or any other non-lymphoid tissue. Still, official guidelines do not specify which technique should be used to assess infiltration. We assessed the agreement among flow cytometry (FC), blood smear evaluation, and ADVIA120 (LUC and BASO) to quantify PB infiltration in 100 dogs with large B-cell lymphoma (LBCL). Significant errors were found for all methods compared to FC. A moderate agreement was present between FC and blood smear evaluation, whereas LUC and BASO had excellent specificity but unsatisfactory sensitivity in detecting FC infiltrated PB samples...
May 31, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28594565/structure-formation-in-langmuir-peptide-films-as-revealed-from-coarse-grained-molecular-dynamics-simulations
#19
Volker Knecht, Günter Reiter, Helmut Schlaad, Renate Reiter
Molecular dynamics simulations in conjunction with the Martini coarse-grained model have been used to investigate the (nonequilibrium) behavior of helical 22-residue poly(γ-benzyl-l-glutamate) (PBLG) peptides at the water/vapor interface. Preformed PBLG mono- or bilayers homogeneously covering the water surface laterally collapse in tens of nanoseconds, exposing significant proportions of empty water surface. This behavior was also observed in recent AFM experiments at similar areas per monomer, where a complete coverage had been assumed in earlier work...
June 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28581673/the-role-of-thyroid-fna-cytology-in-pediatric-malignant-lesions-an-overview-of-the-literature
#20
REVIEW
Esther Diana Rossi, Maurizio Martini, Tonia Cenci, Sara Capodimonti, Luigi Maria Larocca
When one is dealing with pediatric thyroid lesions, fine-needle aspiration is the first diagnostic tool for the correct characterization of these nodules. Despite the apparent infrequency of thyroid cancers in children, recent data from the National Cancer Institute prove that the incidence has been increasing, especially in adolescents. With the same data, a higher prevalence of well-differentiated cancers can be estimated, with 90% diagnosed as papillary thyroid cancer. Nonetheless, some publications have demonstrated that some specific malignant variants are more frequent in children and have a more aggressive behavior that justifies the increased number of surgical procedures...
June 5, 2017: Cancer
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