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https://www.readbyqxmd.com/read/29778019/phoenix-dactylifera-protects-against-oxidative-stress-and-hepatic-injury-induced-by-paracetamol-intoxication-in-rats
#1
Gamal A Salem, Ahmed Shaban, Hussain A Diab, Wesam A Elsaghayer, Manal D Mjedib, Aomassad M Hnesh, Ravi P Sahu
The current studies were sought to determine effects of antioxidant potential of aqueous and methanolic extracts of Phoenix dactylifera leaves (PLAE and PLME) against the widely-used analgesic paracetamol (PCM) induced hepatotoxicity. Groups of rats were treated with or without PCM (1500 mg/kg), PLAE and PLME (300 mg/kg) and n-acetylcysteine (NAC, 50 mg/kg) followed by assessments of liver function tests, oxidative stress, antioxidant defenses, and hepatotoxicity. We observed that PCM significantly elevated serum liver markers, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), and bilirubin compared to control (untreated) group...
May 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29777833/endocrine-disrupting-activities-and-immunomodulatory-effects-in-lymphoblastoid-cell-lines-of-diclofenac-4-hydroxydiclofenac-and-paracetamol
#2
Ivana Klopčič, Tijana Markovič, Irena Mlinarič-Raščan, Marija Sollner Dolenc
A critical literature review reveals that knowledge of side effects of pharmaceuticals diclofenac and paracetamol is extremely important because of their widespread use and occurrence in the environment. In order to delineate whether these compounds have endocrine activity and influence on the immune system, we assessed the potential endocrine disrupting and immunomodulatory activities of: diclofenac (DIC), its metabolite 4-hydroxydiclofenac (4-HD) and paracetamol (PAR). Herein, we report on their impact on estrogen receptor (ER), androgen receptor (AR), glucocorticoid receptor (GR) and thyroid hormone receptor (TR)...
May 16, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29768875/sensitive-determination-of-dopamine-and-paracetamol-based-on-carbon-nanotubes-supported-pd-nanoparticles
#3
Haitang Yang, Xiaoyu Zhao, Haibo Chang, Ruimin Xing, Jing-He Yang, Shanhu Liu, D Xiuhua Liu
A novel chemically modified electrode was constructed in this study based on the carbon nanotubes-supported Pd nanoparticles (Pd/CNTs). It was demonstrated that the sensor could be used for the determination of dopamine (DA) and paracetamol (PA). The measurements were carried out through application of cyclic voltammetry (CV), differential pulse voltammetry (DPV) and amperometric i-t curve. Under optimum conditions and using the amperometric i-t curve method, the modified electrode provided linear response versus dopamine concentrations in the range of 0...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29767826/accidental-or-intentional-exposure-to-potentially-toxic-medications-natural-toxins-and-chemicals-during-pregnancy-analysis-of-data-from-tox-info-suisse
#4
Tabea Vogel, Saskia Lüde, Rahel Baumgartner, Christine Rauber-Lüthy, Ana Paula Simões-Wüst
OBJECTIVE: Affected women and health professionals are still often unsure about how to react to exposures to potentially harmful agents during pregnancy. We wanted to find out which agents worry both pregnant women and professionals, under what circumstances the exposures take place, how they are currently dealt with and how serious they are. METHODS: Making use of the archives of Tox Info Suisse, the foundation that provides poisons information in Switzerland both for members of the general public and for healthcare professionals, we set up an analysis of exposures to possibly harmful agents during pregnancy...
May 16, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29763832/the-impact-of-a-pain-assessment-intervention-on-pain-score-and-analgesic-use-in-older-nursing-home-residents-with-severe-dementia-a-cluster-randomised-controlled-trial
#5
Hanne Marie Rostad, Inger Utne, Ellen Karine Grov, Milada Cvancarova Småstuen, Martine Puts, Liv Halvorsrud
BACKGROUND: Pain is highly prevalent in older adults, especially those in institutional settings such as nursing homes. The presence of dementia may increase the risk of underdiagnosed and undertreated pain. Pain assessment tools are not regularly used in clinical practice, however, there are indications that the regular use of pain assessments tools may influence the recognition of pain by nursing staff and thereby affect pain management. OBJECTIVES: To assess whether regular pain assessment using a pain assessment tool is associated with changes in i) pain scores and ii) analgesic use in nursing home residents with severe dementia...
April 30, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29759210/smart-bi-metallic-perovskite-nanofibers-as-selective-and-reusable-sensors-of-nano-level-concentrations-of-non-steroidal-anti-inflammatory-drugs
#6
Mona A Mohamed, Menna M Hasan, Ibrahim H Abdullah, Ahmed M Abdellah, Ali M Yehia, Nashaat Ahmed, Walaa Abbas, Nageh K Allam
A strategy for trace-level carbon-based electrochemical sensors is investigated via exploring the interesting properties of BaNb2 O6 nanofibers (NFs). Utilizing adsorptive stripping square wave voltammetry (ASSWV), an electrochemical sensing platform was developed based on BaNb2 O6 nanofibers-modified carbon paste electrode (CPE) for the sensitive detection of lornoxicam (LOR). Different techniques were used to characterize the fabricated BaNb2 O6 perovskite NFs. The obtained data show the feasibility to electro-oxidize LOR and paracetamol (PAR) on the surface of the fabricated sensor...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29759063/discontinuation-of-the-pace-plus-trial-problems-in-patient-recruitment-in-general-practice
#7
M Schreijenberg, P A J Luijsterburg, Y D M Van Trier, D Rizopoulos, M A Koopmanschap, L Voogt, C G Maher, B W Koes
BACKGROUND: The PACE Plus trial was a multi-center, double-blinded, superiority randomized controlled trial (RCT) conducted in patients from Dutch general practice to investigate the efficacy of paracetamol and NSAIDs in acute non-specific low back pain (LBP). Because insufficient numbers of patients could be recruited (only four out of the required 800 patients could be recruited over a period of 6 months), the trial was prematurely terminated in February 2017, 6 months after the start of recruitment...
May 14, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29753720/enhanced-amperometric-detection-of-paracetamol-by-immobilized-cobalt-ion-on-functionalized-mwcnts-chitosan-thin-film
#8
Shamima Akhter, Wan Jefrey Basirun, Yatimah Alias, Mohd Rafie Johan, Samira Bagheri, Md Shalauddin, Magaji Ladan, Nadzirah Sofia Anuar
In the present study, a nanocomposite of f-MWCNTs-chitosan-Co was prepared by the immobilization of Co(II) on f-MWCNTs-chitosan by a self-assembly method and used for the quantitative determination of paracetamol (PR). The composite was characterized by field emission scanning electron microscopy (FESEM) and energy dispersive x-ray analysis (EDX). The electroactivity of cobalt immobilized on f-MWCNTs-chitosan was assessed during the electro-oxidation of paracetamol. The prepared GCE modified f-MWCNTs/CTS-Co showed strong electrocatalytic activity towards the oxidation of PR...
May 10, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29751313/occurrence-fate-and-removal-of-pharmaceuticals-personal-care-products-and-pesticides-in-wastewater-stabilization-ponds-and-receiving-rivers-in-the-nzoia-basin-kenya
#9
Kenneth Otieno K'oreje, Faith Jebiwot Kandie, Leendert Vergeynst, Margaret Akinyi Abira, Herman Van Langenhove, Maurice Okoth, Kristof Demeestere
Although there is increased global environmental concern about emerging organic micropollutants (EOMPs) such as pharmaceuticals, personal care products (PPCPs) and polar pesticides, limited information is available on their occurrence in Africa. This study presents unique data on concentrations and loads of 31 PPCPs and 10 pesticides in four wastewater stabilization ponds (WSPs) and receiving rivers (flowing through urban centres) in Kenya. The WSPs indicate a high potential to remove pharmaceutically active compounds (PhACs) with removals by up to >4 orders of magnitude (>99...
May 8, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29751245/paracetamol-toxicity-and-microbial-utilization-pseudomonas-moorei-kb4-as-a-case-study-for-exploring-degradation-pathway
#10
Joanna Żur, Danuta Wojcieszyńska, Katarzyna Hupert-Kocurek, Ariel Marchlewicz, Urszula Guzik
Paracetamol, a widely used analgesic and antipyretic drug, is currently one of the most emerging pollutants worldwide. Besides its wide prevalence in the literature only several bacterial strains able to degrade this compound have been described. In this study, we isolated six new bacterial strains able to remove paracetamol. The isolated strains were identified as the members of Pseudomonas, Bacillus, Acinetobacter and Sphingomonas genera and characterized phenotypically and biochemically using standard methods...
May 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29748452/influence-of-allergic-rhinitis-in-children-and-adolescents-with-recurrent-headache
#11
Francesco Maria Passali, Maria Carla Spinosi, Giulia Mignacco, Cemal Cingi, Hugo Anibal Rodriguez, Desiderio Passali
INTRODUCTION: Migraine and allergies are a common occurrence. The aim of this study was to investigate the relationship between respiratory allergy and migraine in childhood. MATERIALS AND METHODS: We screened 800 children for headache and its characteristics. After that we investigated the presence of allergy performing prick tests, rhinoscopy, endoscopy, rhinomanometry, cytology and mucociliary clearance tests. RESULTS: Out of 800 children screened, 96 suffered from headache...
April 30, 2018: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29742719/cauda-equina-syndrome-following-an-uneventful-spinal-anesthesia-in-a-patient-undergoing-drainage-of-the-bartholin-abscess-a-case-report
#12
Waldo Merino-Urrutia, Milca Villagrán-Schmidt, Priscilla Ulloa-Vásquez, Rubén Carrasco-Moyano, Alberto Uribe, Nicoleta Stoicea, Sergio D Bergese
RATIONALE: Neuraxial anesthesia is a commonly used type of regional anesthesia. Cauda equina syndrome is an unusual and severe complication of neuraxial anesthesia, and is caused by damage to the sacral roots of the neural canal. We present a case of cauda equina syndrome following spinal anesthesia in a patient who underwent Bartholin abscess drainage. PATIENT CONCERNS: A 23-year old female scheduled to undergo surgical drainage of Bartholin abscess. Spinal anesthesia was performed with bupivacaine and fentanyl...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29741427/time-course-of-subacute-pain-after-transoral-robotic-surgery-tors-for-oropharyngeal-squamous-cell-carcinoma-versus-traditional-bilateral-tonsillectomy-in-adults-a-case-control-study
#13
Susanne Irene Scott, Anne Kathrine Østergaard Madsen, Niclas Rubek, Hani Ibrahim Channir, Henrik Kehlet, Christian von Buchwald
OBJECTIVE: To examine pain after Transoral Robotic Surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC) versus traditional bilateral tonsillectomy in adults. METHODS: Pain evolvement was assessed in a prospective case-control design of 16 consecutive patients treated with TORS for early stage OPSCC versus 12 patients, who underwent bilateral tonsillectomy on suspicion of malignant disease. The TORS group received an optimized analgesia regime of preoperative oral celecoxib and gabapentin, intra- and postoperative high-dose intravenous dexamethasone, and regular postoperative oral contalgin, gabapentin, celecoxib, paracetamol and rescue morphine...
May 9, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29739543/special-indications-for-opioid-free-anaesthesia-and-analgesia-patient-and-procedure-related-including-obesity-sleep-apnoea-chronic-obstructive-pulmonary-disease-complex-regional-pain-syndromes-opioid-addiction-and-cancer-surgery
#14
REVIEW
Adrian Sultana, David Torres, Roman Schumann
Opioid-free anaesthesia (OFA) is a technique where no intraoperative systemic, neuraxial or intracavitary opioid is administered with the anaesthetic. Opioid-free analgesia similarly avoids opioids in the perioperative period. There are many compelling reasons to avoid opioids in the surgical population. A number of case reports and, increasingly, prospective studies from all over the world support its benefits, especially in the morbidly obese population with or without sleep apnoea. A derivative technique is opioid sparing, where the same techniques are used but some opioid use is allowed...
December 2017: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/29738273/the-antipyretic-effect-of-paracetamol-occurs-independent-of-transient-receptor-potential-ankyrin-1-mediated-hypothermia-and-is-associated-with-prostaglandin-inhibition-in-the-brain
#15
Elahe Mirrasekhian, Johan L Å Nilsson, Kiseko Shionoya, Anders Blomgren, Peter M Zygmunt, David Engblom, Edward D Högestätt, Anders Blomqvist
The mode of action of paracetamol (acetaminophen), which is widely used for treating pain and fever, has remained obscure, but may involve several distinct mechanisms, including cyclooxygenase inhibition and transient receptor potential ankyrin 1 (TRPA1) channel activation, the latter being recently associated with paracetamol's propensity to elicit hypothermia at higher doses. Here, we examined whether the antipyretic effect of paracetamol was due to TRPA1 activation or cyclooxygenase inhibition. Treatment of wild-type and TRPA1 knockout mice rendered febrile by immune challenge with LPS with a dose of paracetamol that did not produce hypothermia (150 mg/kg) but is known to be analgetic, abolished fever in both genotypes...
May 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29737243/subcutaneous-administration-of-paracetamol-good-local-tolerability-in-palliative-care-patients-an-observational-study
#16
Benoît F Leheup, Stéphanie Ducousso, Stéphane Picard, Raphaël Alluin, Christophe Goetz
BACKGROUND: The subcutaneous route is widely used in both palliative care and geriatrics. Numerous compounds are administered by this route, including paracetamol. However, there is no recommendation on which to base this latter practice and, in the absence of published evidence, nothing is known regarding its local tolerability in palliative care patients. AIM: The main objective of this study was to assess the local tolerability of paracetamol when administered subcutaneously for analgesic or antipyretic purposes in patients hospitalized in the palliative care unit...
May 1, 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29736375/the-effect-of-adjunct-caudal-block-on-postoperative-analgesia-in-robot-assisted-laparoscopic-radical-prostatectomy-a-prospective-randomized-controlled-single-blinded-pilot-study-in-a-tertiary-centre
#17
Kenneth Chen, Allen Sim, Alex Ford Kan
Objective: Caudal block provides satisfactory postoperative pain relief in lower abdominal operations. This pilot study explores its safety and effect on postoperative pain control in patients who underwent robot-assisted laparoscopic radical prostatectomy (RARP). Methods: From 2013 to 2014, 40 consecutive patients were randomized into two groups - one received caudal block using ropivacaine immediately after operation, the other received standard analgesia. Primary outcome measure was pain score based on 11-point Likert scale (0-10) recorded at recovery room, and at 6, 12, 24, 48, and 72 h after operation...
April 2018: Asian Journal of Urology
https://www.readbyqxmd.com/read/29734452/hepatoprotective-potential-of-elsholtzia-densa-against-acute-and-chronic-models-of-liver-damage-in-wistar-rats
#18
Ovais Ahmad Zargar, Rohina Bashir, Showkat Ahmad Ganie, Akbar Masood, Mohammad Afzal Zargar, Rabia Hamid
The aim of the present study was to evaluate the hepatoprotective activity of methanolic extract of Elsholtzia densa against experimentally induced acute (CCl4 ) and chronic (paracetamol) liver injury in albino wistar rats. Activity was measured by monitoring the serum levels of ALT, ALP AST and LDH, total protein levels, bilirubin and albumin. The results of the CCl4 and paracetamol-induced liver toxicity experiments showed that the rats treated with the methanolic extract of Elsholtzia densa exhibited a significant decrease in biochemical parameters as well as the proteins, which were all elevated in the CCl4 and paracetamol group...
May 7, 2018: Drug Research
https://www.readbyqxmd.com/read/29732985/treatment-of-chronic-articular-pain-in-adults-with-hemophilia
#19
E Carlos Rodriguez-Merchan
INTRODUCTION: Adult people with hemophilia (PWH) mainly use Factor VIII/Factor IX (FVIII/FIX) to lessen chronic articular pain, followed in frequency by nonsteroidal anti-inflammatory drugs. Analgesics are used by only one-third of adult PWH. Limitations in activities of daily living are encountered in the large majority of PWH, and most describe pain as affecting their state of mind. A review of the literature on their treatment is important because chronic pain in adult PWH is often undertreated or wrongly treated, causing psychological problems for these patients...
May 3, 2018: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/29729521/pain-management-for-up-to-9-weeks-medical-abortion-an-international-survey-among-abortion-providers
#20
Christian Fiala, Sharon Cameron, Teresa Bombas, Mirella Parachini, Aubert Agostini, Roberto Lertxundi, Kristina Gemzell-Danielsson
OBJECTIVES: although some degree of pain is inevitable with first trimester medical abortion, little information is available regarding its management in daily practice. The aim of the work was to determine the current regimens in use for managing pain associated with medical abortion. STUDY DESIGN: a self-administered internet survey, developed by a group of European experts on medical abortion, was circulated internationally among medical abortion providers. RESULTS: A total of 283 valid questionnaires were completed, mainly from European providers (59% of respondents, n = 167)...
April 26, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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