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Mirtazapine

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https://www.readbyqxmd.com/read/29678261/mirtazapine
#1
Abdulrahman Al-Majed, Ahmed H Bakheit, Raed M Alharbi, Hatem A Abdel Aziz
Mirtazapine is one of antidepression which is used mainly in the treatment of depression, moreover, it is sometimes used in the treatment of anxiety disorders, insomnia, nausea, and vomiting, and to produce weight gain when desirable. The action of mirtazapine is an antagonist of certain adrenergic and serotonin receptors, and, furthermore, the drug is used strong as antihistamine, and it is occasionally defined as a noradrenergic and specific serotonergic antidepressant (NaSSA). The comprehensive profile of mirtazapine gives more detailed information about nomenclature, formulae, elemental analysis, and appearance...
2018: Profiles of Drug Substances, Excipients, and related Methodology
https://www.readbyqxmd.com/read/29677603/the-comparative-evidence-basis-for-the-efficacy-of-second-generation-antidepressants-in-the-treatment-of-depression-in-the-us-a-bayesian-meta-analysis-of-food-and-drug-administration-reviews
#2
Rei Monden, Annelieke M Roest, Don van Ravenzwaaij, Eric-Jan Wagenmakers, Richard Morey, Klaas J Wardenaar, Peter de Jonge
BACKGROUND: Studies have shown similar efficacy of different antidepressants in the treatment of depression. METHOD: Data of phase-2 and -3 clinical-trials for 16 antidepressants (levomilnacipran, desvenlafaxine, duloxetine, venlafaxine, paroxetine, escitalopram, vortioxetine, mirtazapine, venlafaxine XR, sertraline, fluoxetine, citalopram, paroxetine CR, nefazodone, bupropion, vilazodone), approved by the FDA for the treatment of depression between 1987 and 2016, were extracted from the FDA reviews that were used to evaluate efficacy prior to marketing approval, which are less liable to reporting biases...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29668490/low-dose-mirtazapine-in-major-depression-developed-after-hyperemesis-gravidarum-a-case-series
#3
Faruk Uguz, Keziban Turgut, Adem Aydin, Mehmet Ak
No abstract text is available yet for this article.
April 9, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29665098/patterns-of-antidepressant-use-during-pregnancy-a-nationwide-population-based-cohort-study
#4
Anne Bénard-Laribière, Elodie Pambrun, Anne-Laure Sutter-Dallay, Sophie Gautier, Caroline Hurault-Delarue, Christine Damase-Michel, Isabelle Lacroix, Bernard Bégaud, Antoine Pariente
AIMS: We explored the patterns of antidepressant use during pregnancy. METHODS: A cohort of women who started a pregnancy in 2014 was identified using data from the French reimbursement healthcare system (covering approximately 99% of the population). Antidepressant uses (initiated before or during pregnancy) were assessed. Explored changes in antidepressant treatment were: associations, switches, discontinuation, and resumption of antidepressants during pregnancy...
April 17, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29663484/association-between-psychotropic-medications-and-presence-of-sleep-bruxism-a-systematic-review
#5
REVIEW
Gilberto Melo, Kamile Leonardi Dutra, Rubens Rodrigues Filho, Adriana de Oliveira Lira Ortega, André Luís Porporatti, Bruce Dick, Carlos Flores-Mir, Graziela De Luca Canto
The purpose of this study was to systematically review the literature for studies that investigated the association between use of psychotropic medications and presence of sleep bruxism (SB). Observational studies were selected in a two-phase process. Searches were performed on six electronic databases and a grey literature search was conducted on three databases. SB diagnosis was based on questionnaires or clinical examinations; no polysomnography exams were performed. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Analytical Cross-Sectional Studies...
April 16, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29649674/are-there-clinical-and-neurophysiologic-predictive-factors-for-a-positive-response-to-hf-rtms-in-patients-with-treatment-resistant-depression
#6
Anna Poleszczyk, Maria Rakowicz, Tadeusz Parnowski, Jakub Antczak, Łukasz Święcicki
Better selection of patients with treatment-resistant depression for high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) would make the procedure more efficient. The objective of this study was to search for clinical and neurophysiologic predictors of therapeutic response with a special focus on the bipolar population. Forty patients (30 bipolar) underwent 20 daily sessions of HF-rTMS. Clinical outcome measures included the 21-item Hamilton Depression Rating Scale, the Beck Depression Inventory, the Clinical Global Impression, and the Patient Global Impression...
April 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29626184/tachyphylaxis-to-the-sedative-action-of-mirtazapine
#7
Georgios Papazisis, Spyridon Siafis, Dimitrios Tzachanis
BACKGROUND The pharmacological term tachyphylaxis is used to describe rapidly occurring response desensitization, a situation where the biological response to a given drug dose diminishes when it is given continuously. This pharmacological phenomenon is well observed in some drug categories such as ephedrine, nitrates, beta blockers and H2 antagonists. Mirtazapine is a widely-used antidepressant with a multimodal mechanism of action. CASE REPORT In the present case, we report rapid onset and consistent tachyphylaxis regarding the sedative action of mirtazapine in a 30-year-old female...
April 7, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29617396/the-impact-of-depression-and-antidepressant-usage-on-primary-biliary-cholangitis-clinical-outcomes
#8
Abdel-Aziz Shaheen, Gilaad G Kaplan, Wagdi Almishri, Isabelle Vallerand, Alexandra D Frolkis, Scott Patten, Mark G Swain
BACKGROUND: Depression is prevalent in primary biliary cholangitis (PBC) patients. Our aims were to examine the effects of depression and antidepressants on hepatic outcomes of PBC patients. METHODS: We used the UK Health Improvement Network database to identify PBC patients between 1974 and 2007. Our primary outcome was one of three clinical events: decompensated cirrhosis, liver transplantation and death. We assessed depression and each class of antidepressant medication in adjusted multivariate Cox proportional hazards models to identify independent predictors of outcomes...
2018: PloS One
https://www.readbyqxmd.com/read/29611870/initial-severity-of-major-depression-and-efficacy-of-new-generation-antidepressants-individual-participant-data-meta-analysis
#9
T A Furukawa, K Maruo, H Noma, S Tanaka, H Imai, K Shinohara, K Ikeda, S Yamawaki, S Z Levine, Y Goldberg, S Leucht, A Cipriani
OBJECTIVE: The role of baseline severity as effect modifier in various psychiatric disorders is a topic of controversy and of clinical import. This study aims to examine whether baseline severity modifies the efficacy of various antidepressants for major depression through individual participant data (IPD) meta-analysis. METHOD: We identified all placebo-controlled, double-blind randomised trials of new generation antidepressants in the acute phase treatment of major depression conducted in Japan and requested their IPD through the public-private partnerships (PPPs) between the relevant academic societies and the pharmaceutical companies...
April 3, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29588433/sexual-dysfunction-in-patients-with-antidepressant-treated-anxiety-or-depressive-disorders-a-pragmatic-multivariable-longitudinal-study
#10
S Preeti, S D Jayaram, A Chittaranjan
OBJECTIVE: To investigate early evolution, tolerability, and predictors of antidepressant-emergent sexual dysfunction in patients with anxiety or depressive disorder. METHODS: Patients with anxiety or depressive disorders who were prescribed antidepressant monotherapy (mirtazapine, sertraline, desvenlafaxine, escitalopram, or fluoxetine) at the discretion of the treating clinician were recruited from July 2012 to June 2014 from a hospital outpatient service. All were free of psychotropic medication for least 1 month...
March 2018: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
https://www.readbyqxmd.com/read/29587564/mirtazapine-attenuates-nicotine-seeking-behavior-in-rats
#11
Susana Barbosa-Méndez, Alberto Salazar-Juárez
BACKGROUND: Nicotine is the major psychoactive component of tobacco. A number of pharmacological therapies have been evaluated, with poor results. Given the lack of success of these therapies, several authors have proposed alternative therapeutic strategies. One of these is the use of antidepressant drugs that may have a specific effect on the neural pathways or receptors underlying nicotine addiction. Mirtazapine is an antagonist of α2 NE receptors (noradrenergic receptor), 5-HT2A/C and 5-HT3 receptors and has demonstrated efficacy in reducing behavioral effects induced by drugs of abuse in human and animal models...
March 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29575543/identifying-off-label-prescriptions-through-data-mining-in-danish-community-pharmacy-servers-an-exploratory-study-on-desmopressin-diclofenac-fucidin-mirtazapine-and-quetiapine
#12
Monika Andrulyte, Ole Jannik Bjerrum
The term off-label use describes the prescription and administration of medicines outside of the terms for which it officially has been approved, including age, dose and indication. Off-label data can be generated from the Danish National Prescription Registry (DNPR) through combinations with diagnoses, however the community pharmacy servers provide equal, local, albeit less data through a faster and less constrained collection process. The data collection for this exploratory study took place at five community pharmacies in Denmark...
March 25, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29575226/discontinuation-and-dose-adjustment-of-metoprolol-after-metoprolol-paroxetine-fluoxetine-co-prescription-in-dutch-elderly
#13
Muh Akbar Bahar, Yuanyuan Wang, Jens H J Bos, Bob Wilffert, Eelko Hak
PURPOSE: Co-prescription of paroxetine/fluoxetine (a strong CYP2D6 inhibitor) in metoprolol (a CYP2D6 substrate) users is common, but data on the clinical consequences of this drug-drug interaction are limited and inconclusive. Therefore, we assessed the effect of paroxetine/fluoxetine initiation on the existing treatment with metoprolol on the discontinuation and dose adjustment of metoprolol among elderly. METHODS: We performed a cohort study using the University of Groningen IADB...
March 24, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29544744/the-impact-of-depression-medications-on-oral-antidiabetic-drug-adherence-in-patients-with-diabetes-and-depression
#14
Shan Xing, Gregory S Calip, Alex D Leow, Shiyun Kim, Glen T Schumock, Daniel R Touchette, Todd A Lee
AIMS: To compare adherence and persistence to oral antidiabetic drugs (OAD) between patients who are new users of second generation antipsychotics (SGA) versus new users of other depression therapies in adults with type 2 diabetes mellitus (T2DM) and major depressive disorder (MDD). METHODS: Adults 18-64 years with previously-treated T2DM and MDD (past OAD and SSRI/SNRI use) who are new users of SGA or non-SGA therapies (bupropion, lithium, mirtazapine, thyroid hormone, tricyclic antidepressant) were identified in the 2009-2015 MarketScan® Commercial Claims and Encounters database...
December 27, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29529010/potential-of-oral-fluid-as-a-clinical-specimen-for-compliance-monitoring-of-psychopharmacotherapy
#15
Jasna Neumann, Olof Beck, Norbert Dahmen, Michael Böttcher
BACKGROUND: Oral fluid (OF) is being developed as a specimen for the determination of drug intake as an alternative to serum and plasma. It is generally considered as an attractive specimen due to the noninvasive nature of the sampling procedure and the relation to the free fraction of drug in the blood. These features are of particular value in drug treatment of psychiatric disorders. To establish OF for the purpose of monitoring drug therapy, the relationship between concentrations in OF and serum/plasma must be documented...
April 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29522941/validating-pre-treatment-body-mass-index-as-moderator-of-antidepressant-treatment-outcomes-findings-from-co-med-trial
#16
Manish K Jha, Shereen Wakhlu, Neha Dronamraju, Abu Minhajuddin, Tracy L Greer, Madhukar H Trivedi
BACKGROUND: Currently, there are no valid clinical or biological markers to personalize the treatment of depression. Recent evidence suggests that body mass index (BMI) may guide the selection of antidepressant medications with different mechanisms of action. METHODS: Combining Medications to Enhance Depression Outcomes (CO-MED) trial participants with BMI measurement (n = 662) were categorized as normal- or underweight (<25), overweight (25-<30), obese I (30-<35), and obese II+ (≥35)...
February 27, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29514662/antidepressant-use-and-risk-of-adverse-outcomes-in-people-aged-20-64-years-cohort-study-using-a-primary-care-database
#17
Carol Coupland, Trevor Hill, Richard Morriss, Michael Moore, Antony Arthur, Julia Hippisley-Cox
BACKGROUND: Antidepressants are one of the most commonly prescribed medications in young and middle-aged adults, but there is relatively little information on their safety across a range of adverse outcomes in this age group. This study aimed to assess associations between antidepressant treatment and several adverse outcomes in people aged 20-64 years diagnosed with depression. METHODS: We conducted a cohort study in 238,963 patients aged 20-64 years registered with practices across the UK contributing to the QResearch primary care database...
March 8, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29507502/progressive-multifocal-leukoencephalopathy-during-ixazomib-based-chemotherapy
#18
C P Sawicki, S A Climans, C C Hsia, J A Fraser
Progressive multifocal leukoencephalopathy (pml) is a rare demyelinating disease of the central nervous system that most often affects immunocompromised individuals. It is caused by the reactivation of the John Cunningham virus (jcv), which is found in latent form in the majority of adults. We describe a 59-year-old man with multiple myeloma who developed severe neurological deficits during treatment with ixazomib-based chemotherapy. A diagnosis of pml was established with gadolinium-enhanced magnetic resonance imaging (mri) and by detection of jcv in the cerebrospinal fluid...
February 2018: Current Oncology
https://www.readbyqxmd.com/read/29499579/-sleep-disorders-and-impaired-sleep-as-adverse-drug-reactions-of-psychotropic-drugs-an-evaluation-of-data-of-summaries-of-product-characteristics
#19
Maximilian Gahr, Bernhard J Connemann, René Zeiss, Albrecht Fröhlich
OBJECTIVE:  Psychopharmacotherapy is essential in the treatment of many mental disorders. Adverse drug reactions (ADR) have impact on compliance and tolerability. Sleep disorders or impaired sleep may occur as ADRs of psychopharmacotherapy. Sleep disorders are associated with an increased risk for physical and mental illness and may impair cognition, impulse control, emotion regulation and mood. Objective of the following study was the systematic presentation of type and risk of sleep disorders/impairments of sleep of frequently prescribed psychotropic drugs...
March 2, 2018: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29497578/the-benefit-of-mirtazapine-in-the-treatment-of-progressive-multifocal-leukoencephalopathy-in-a-young-hiv-positive-patient-a-case-report
#20
Carola Mullins, Jorge Miranda, Hugo Sandoval, Luis Ramos-Duran, Silvina B Tonarelli
Highly active antiretroviral therapy is well-established in the treatment of human immunodeficiency virus (HIV)-positive patients. Nonadherence with therapy regimens often leads to the occurrence of opportunistic infections that further complicate treatment and challenge the treating physician. We report a young HIV-positive patient who suffered from progressive multifocal leukoencephalopathy caused by the human John Cunningham virus and showed objective clinical improvement after adding mirtazapine to the treatment regimen, an observation that is supported by the emerging literature...
February 1, 2018: Innovations in Clinical Neuroscience
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