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Mirtazapine

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https://www.readbyqxmd.com/read/28213170/non-response-at-week-4-as-clinically-useful-indicator-for-antidepressant-combination-in-major-depressive-disorder-a-sequential-rct
#1
Masaki Kato, Yoshiteru Takekita, Yosuke Koshikawa, Shiho Sakai, Hiroki Bandou, Keiichiro Nishida, Naotaka Sunada, Ai Onohara, Yoshiyuki Hatashita, Alessandro Serretti, Toshihiko Kinoshita
We aimed to compare the efficacy and tolerability of mirtazapine versus SSRIs and to assess whether "non-response at week 4" may be a clinical indicator for combining mirtazapine and SSRIs for subsequent treatment. One-hundred fifty-four outpatients with MDD were randomized to receive mirtazapine or SSRIs in step I (4 weeks). Non-responders in step I were randomly assigned to either mirtazapine or SSRIs monotherapy or their combination in step IIa while responders in step I continued the same monotherapy in step IIb for 4 weeks...
February 3, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28149505/case-report-severe-hypernatremia-from-psychogenic-adipsia
#2
Sarah Manning, Rehan Shaffie, Shitij Arora
Hypernatremia is a common emergency room presentation and carries high mortality. We describe a case of a 56-year-old male patient with who presents with refusal to drink water for several weeks leading to the admission. He was diagnosed with psychogenic adipsia and was treated successfully with fluids, mirtazapine and clonazepam.
2017: F1000Research
https://www.readbyqxmd.com/read/28149320/antidepressive-response-of-inpatients-with-major-depression-to-adjuvant-occupational-therapy-a-case-control-study
#3
Marc-Andreas Edel, Brian Blackwell, Markus Schaub, Barbara Emons, Tanja Fox, Friederike Tornau, Bernward Vieten, Patrik Roser, Ida Sibylle Haussleiter, Georg Juckel
BACKGROUND: Despite marked costs and limited evidence regarding effectiveness, occupational therapy (OT) is widely applied in psychiatric settings and financed by health insurance companies in European countries. This pilot study investigated the antidepressive effects of adjuvant OT for patients with major depression in a 6-week inpatient setting, stratified for females and males. METHODS: A total of 114 inpatients with major depression were assigned to either a standard OT group (using basic handcraft) or an active control group that played board games (2 h daily, 5 days a week)...
2017: Annals of General Psychiatry
https://www.readbyqxmd.com/read/28141599/gastrointestinal-hemorrhage-related-to-fluoxetine-in-a-patient-with-stroke
#4
Tze Chao Wee
We report on a patient who developed massive gastrointestinal hemorrhage related to the use of fluoxetine in combination with aspirin and clopidogrel. A 58-year-old man was admitted with a posterior circulation infarct with significant weakness in all four limbs and dysarthria. Aspirin and clopidogrel were started. Fluoxetine was started for pharmacological neurostimulation to promote motor recovery and for low mood. He developed gastrointestinal hemorrhage a week after fluoxetine was started. Fluoxetine was suspended and investigations failed to reveal the source of the bleeding...
January 30, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28138116/mirtazapine-is-effective-in-steroid-withdrawal-syndrome-related-depression-a-case-report
#5
Sourav Khanra, Sourav Das
Steroid withdrawal syndrome (SWS) following steroid dependence is becoming a common clinical condition. It may be associated with body image disorder. Though selective serotonin reuptake inhibitors (SSRIs) are found to be effective SWS associated depression, data for this clinical condition is limited. We present a case of SWS associated with body image disorder which improved with mirtazapine. Mirtazapine might be better option than SSRIs in this subgroup of patients for its noradrenergic property and better gastrointestinal profile...
February 28, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28130646/the-effect-of-mirtazapine-on-dopaminergic-psychosis-and-dyskinesia-in-the-parkinsonian-marmoset
#6
Adjia Hamadjida, Stephen G Nuara, Nicolas Veyres, Imane Frouni, Cynthia Kwan, Lamia Sid-Otmane, Mery-Jane Harraka, Jim C Gourdon, Philippe Huot
BACKGROUND: Parkinson's disease (PD) psychosis is encountered in as many as 50% of patients with advanced disease. Treatment options for PD psychosis are few. In fact, only clozapine and pimavanserin have shown efficacy in randomised controlled trials. Clinicians are often reluctant to prescribe the former, due to the risk of agranulocytosis, while the latter is not widely available yet. Because it is already clinically available and exhibits high affinity for serotonin 2A receptors, a target with which both clozapine and pimavanserin interact, we hypothesised that the anti-depressant mirtazapine might be effective to alleviate PD psychosis...
January 27, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28129311/is-mirtazapine-an-effective-treatment-for-nausea-and-vomiting-of-pregnancy-a-case-series
#7
Oguz Omay, Adrienne Einarson
No abstract text is available yet for this article.
January 26, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28114093/-cotard-s-syndrome-case-report-and-a-brief-review-of-literature
#8
N P Moschopoulos, S Kaprinis, J Nimatoudis
The term "Cotard's syndrome" is used to describe a number of clinical features, mostly hypochondriac and nihilistic delusions, the most characteristic of which are the ideas "I am dead" and "my internal organs do not exist". Besides, anxious and depressed mood, delusions of damnation, possession and immortality, suicidal and self-mutilating behavior are included. The first description of the syndrome was made in 1880 by Cotard, who presented the case of a female patient in a lecture. He originally named it "hypochondriac delusion", and some years later "delusion of negations", while it was named "Cotard delusion" after his death...
October 2016: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28111062/psychotropic-medication-use-among-medicare-beneficiaries-following-traumatic-brain-injury
#9
Jennifer S Albrecht, Daniel C Mullins, Gordon S Smith, Vani Rao
OBJECTIVES: To characterize psychotropic medication use before and after traumatic brain injury (TBI) hospitalization among older adults. A secondary objective is to determine how receipt of indicated pharmacologic treatment for anxiety and post-traumatic stress disorder (PTSD) differs following TBI. DESIGN: Retrospective cohort. SETTING: United States. PARTICIPANTS: Medicare beneficiaries aged ≥65 years hospitalized with TBI between 2006 and 2010 with continuous drug coverage for 12 months before and after TBI (N = 60,276)...
December 28, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28096225/not-so-patchy-story-of-attempted-suicide%C3%A2-leading-to-24%C3%A2-hours-of-deep-sleep-and-survival
#10
Adam Joseph Trist, Hardeep Sahota, Lucy Williams
Here, we present a somewhat unusual suicide attempt where, despite an unbelievable overdose with transdermal fentanyl patches, the patient survived. The patient-a woman aged 70 years, who has suffered from chronic back pain despite starting transdermal fentanyl patches in 2007. The unconventional method of attempted suicide was based on online research into deaths from fentanyl patch toxicity. She had gradually accumulated 100 µg fentanyl patches from repeat prescriptions, applying 14 patches with fatal intent, alongside 2 45 mg mirtazapine tablets, and concurrent therapeutic doses of tramadol and morphine sulfate oral solution...
January 17, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28093029/low-doses-of-mirtazapine-or-quetiapine-for-transient-insomnia-a-randomised-double-blind-cross-over-placebo-controlled-trial
#11
Julie Karsten, Loes A Hagenauw, Jeanine Kamphuis, Marike Lancel
Low doses of the antidepressant mirtazapine or the neuroleptic quetiapine are often prescribed off-label for insomnia. However, studies on the effects on sleep and hangover effects the following day are scarce. In this randomised, double-blind, cross-over, placebo-controlled trial, the influence of 7.5 mg mirtazapine and 50 mg quetiapine on both normal sleep and sleep disturbed by acoustic stress (traffic noise) as a model for transient insomnia was assessed. Additionally, hangover effects on next-day alertness and cognitive functioning were examined...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28070660/treatment-options-for-hyperemesis-gravidarum
#12
REVIEW
Amy Abramowitz, Emily S Miller, Katherine L Wisner
Hyperemesis gravidarum (HG) is a severe and prolonged form of nausea and/or vomiting during pregnancy. HG affects 0.3-2% of pregnancies and is defined by dehydration, ketonuria, and more than 5% body weight loss. Initial pharmacologic treatment for HG includes a combination of doxylamine and pyridoxine. Additional interventions include ondansetron or dopamine antagonists such as metoclopramide or promethazine. The options are limited for women who are not adequately treated with these medications. We suggest that mirtazapine is a useful drug in this context and its efficacy has been described in case studies...
January 9, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28068617/what-does-the-madrs-mean-equipercentile-linking-with-the-cgi-using-a-company-database-of-mirtazapine-studies
#13
Stefan Leucht, Hein Fennema, Rolf R Engel, Marion Kaspers-Janssen, Peter Lepping, Armin Szegedi
BACKGROUND: Little is known about the clinical relevance of the Montgomery Asberg Depression Rating Scale (MADRS) total scores. It is unclear how total scores translate into clinical severity, or how commonly used measures for response (reduction from baseline of ≥50% in the total score) translate into clinical relevance. Moreover, MADRS based definitions of remission vary. METHODS: We therefore compared: a/ the MADRS total score with the Clinical Global Impression - Severity Score (CGI-S) b/ the percentage and absolute change in the MADRS total scores with Clinical Global Impression - Improvement (CGI-I); c/ the absolute and percentage change in the MADRS total scores with CGI-S absolute change...
December 29, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27999253/treatment-of-post-traumatic-stress-disorder-nightmares-at-a-veterans-affairs-medical-center
#14
Mark B Detweiler, Bhuvaneshwar Pagadala, Joseph Candelario, Jennifer S Boyle, Jonna G Detweiler, Brian W Lutgens
The effectiveness of medications for PTSD in general has been well studied, but the effectiveness of medicatio.ns prescribed specifically for post-traumatic stress disorder (PTSD) nightmares is less well known. This retrospective chart review examined the efficacy of various medications used in actual treatment of PTSD nightmares at one Veteran Affairs Hospital. Records at the Salem, VA Veterans Affairs Medical Center (VAMC) were examined from 2009 to 2013 to check for the efficacy of actual treatments used in comparis...
December 16, 2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27974346/nominal-isomers-incorrect-spellings-of-medicines-eluding-researchers-variants-in-the-spellings-of-drug-names-in-pubmed-a-database-review
#15
Robin E Ferner, Jeffrey K Aronson
OBJECTIVE:  To examine how misspellings of drug names could impede searches for published literature. DESIGN:  Database review. DATA SOURCE:  PubMed. REVIEW METHODS:  The study included 30 drug names that are commonly misspelt on prescription charts in hospitals in Birmingham, UK (test set), and 30 control names randomly chosen from a hospital formulary (control set). The following definitions were used: standard names-the international non-proprietary names, variant names-deviations in spelling from standard names that are not themselves standard names in English language nomenclature, and hidden reference variants-variant spellings that identified publications in textword (tw) searches of PubMed or other databases, and which were not identified by textword searches for the standard names...
December 14, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27932047/disturbances-of-glucose-metabolism-associated-with-the-use-of-psychotropic-drugs-a-post-mortem-evaluation
#16
Cristian Palmiere, Marc Augsburger, Vincent Varlet
Treatment with atypical antipsychotic agents and tetracyclic antidepressants has been associated with impaired glycemic control. Reported complications have included new-onset diabetes mellitus, life-threatening diabetic ketoacidosis and, rarely, death. The study presented herein focuses on biochemical investigations of glucose metabolism in a series of medico-legal cases that revealed the presence of atypical antipsychotic agents (clozapine, olanzapine, quetiapine and risperidone) or mirtazapine at toxicology...
December 5, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27902931/human-presynaptic-receptors
#17
REVIEW
Eberhard Schlicker, Thomas Feuerstein
Presynaptic receptors are sites at which transmitters, locally formed mediators or hormones inhibit or facilitate the release of a given transmitter from its axon terminals. The interest in the identification of presynaptic receptors has faded in recent years and it may therefore be justified to give an overview of their occurrence in the autonomic and central nervous system; this review will focus on presynaptic receptors in human tissues. Autoreceptors are presynaptic receptors at which a given transmitter restrains its further release, though in some instances may also increase its release...
November 27, 2016: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27899216/poisoning-suicide-with-ingestion-of-the-pyrethroids-alpha-cypermethrin-and-deltamethrin-and-the-antidepressant-mirtazapine-a-case-report
#18
Vassiliki A Boumba, Georgios N Rallis, Theodore Vougiouklakis
This case report describes a death attributed to the intake of the pyrethroid insecticides, alpha-cypermethrin and deltamethrin, and the antidepressant mirtazapine. The autopsy findings showed absence of external traumatic injuries and internal generalized visceral congestion, edema and cyanosis. The toxicological results revealed the presence of a toxic concentration of mirtazapine (12.5mg/L and 10.7mg/L in blood and urine, respectively) and high concentrations of pyrethroids (2.46mg/L alpha-cypermethrin and 2...
November 22, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27866243/monitoring-of-adherence-to-headache-treatments-by-means-of-hair-analysis
#19
Anna Ferrari, Manuela Licata, Cecilia Rustichelli, Carlo Baraldi, Daniele Vandelli, Filippo Marchesi, Federica Palazzoli, Patrizia Verri, Enrico Silingardi
PURPOSE: The aim of this study was to evaluate the potential of hair analysis to monitor medication adherence in headache patients undergoing chronic therapy. For this purpose, the following parameters were analyzed: the detection rate of 23 therapeutic drugs in headache patients' hair, the degree of agreement between the self-reported drug and the drug found in hair, and whether the levels found in hair reflected the drug intake reported by the patients. METHODS: The study included 93 patients suffering from primary headaches declaring their daily intake of at least one of the following drugs during the 3 months before the hair sampling: alprazolam, amitriptyline, citalopram, clomipramine, clonazepam, delorazepam, diazepam, duloxetine, fluoxetine, flurazepam, levomepromazine, levosulpiride, lorazepam, lormetazepam, mirtazapine, paroxetine, quetiapine, sertraline, topiramate, trazodone, triazolam, venlafaxine, and zolpidem...
February 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27807450/trazodone-addition-to-paroxetine-and-mirtazapine-in-a-patient-with-treatment-resistant-depression-the-pros-and-cons-of-combining-three-antidepressants
#20
Rui Lopes, José Carlos Alves, Raquel Garcia Rego
Dual antidepressant combination for treatment-resistant depression is a strategy well supported by literature and accepted in clinical practice. Rather, the usefulness of the combination of more than two antidepressants is controversial. This may be related to the possibility of higher side-effect burden and to doubts about its pharmacological effectiveness and therapeutic advantage compared to other standard treatment options. We report a relapse of moderate-to-severe depressive symptoms with insomnia that successfully remitted after the addition of trazodone to a dual combination of paroxetine and mirtazapine (in standard effective doses) in a patient with treatment-resistant depression...
2016: Case Reports in Medicine
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