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https://www.readbyqxmd.com/read/29150948/methylation-associated-dok1-and-dok2-down-regulation-potential-biomarkers-for-predicting-adverse-prognosis-in-acute-myeloid-leukemia
#1
Pin-Fang He, Zi-Jun Xu, Jing-Dong Zhou, Xi-Xi Li, Wei Zhang, De-Hong Wu, Zhi-Hui Zhang, Xin-Yue Lian, Xin-Yu Yao, Zhao-Qun Deng, Jiang Lin, Jun Qian
DOK-1 and DOK-2 (DOK1/2) are closely related members of downstream of tyrosine kinase (DOK) family genes, which are found to be frequently rearranged in several hematopoietic cancers. However, the clinical implications of DOK1/2 in acute myeloid leukemia (AML) remain largely unknown. To investigate the clinical significance, real-time quantitative PCR (RQ-PCR) was carried out to detect DOK1/2 expressions in 125 de novo AML patients and 28 healthy controls. Real-time quantitative methylation-specific PCR (RQ-MSP) and bisulfite sequencing PCR (BSP) were applied to detect DOK1/2 methylation level and density...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29150749/study-on-the-interaction-of-paeoniflorin-with-human-serum-albumin-hsa-by-spectroscopic-and-molecular-docking-techniques
#2
Liang Xu, Yan-Xi Hu, Yan-Cheng Li, Yu-Feng Liu, Li Zhang, Hai-Xin Ai, Hong-Sheng Liu
The interaction of paeoniflorin with human serum albumin (HSA) was investigated using fluorescence, UV-vis absorption, circular dichroism (CD) spectra and molecular docking techniques under simulative physiological conditions. The results clarified that the fluorescence quenching of HSA by paeoniflorin was a static quenching process and energy transfer as a result of a newly formed complex (1:1). Paeoniflorin spontaneously bound to HSA in site I (subdomain IIA), which was primarily driven by hydrophobic forces and hydrogen bonds (ΔH° = - 9...
November 17, 2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/29150661/morphological-differentiation-of-brachionus-calyciflorus-caused-by-predation-and-coal-ash-pollution
#3
Ying-Hao Xue, Xiao-Xue Yang, Gen Zhang, Yi-Long Xi
Different rotifer stains exhibited remarkably morphological differences which could not be eliminated under laboratory conditions. In the present study, we hypothesized that predation pressure and pollution might be two forces driving morphological differentiation of rotifer. To test this hypothesis, rotifers (Brachionus calyciflorus) belonging to two sibling species were collected from three special lakes (with coal ash pollution, high predation pressure or neither) and cultured for more than three months to investigate their potential differentiation in morphology...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150655/reverse-engineering-protocols-for-controlling-spin-dynamics
#4
Qi Zhang, Xi Chen, D Guéry-Odelin
We put forward reverse engineering protocols to shape in time the components of the magnetic field to manipulate a single spin, two independent spins with different gyromagnetic factors, and two interacting spins in short amount of times. We also use these techniques to setup protocols robust against the exact knowledge of the gyromagnetic factors for the one spin problem, or to generate entangled states for two or more spins coupled by dipole-dipole interactions.
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150601/decoding-critical-long-non-coding-rna-in-ovarian-cancer-epithelial-to-mesenchymal-transition
#5
Ramkrishna Mitra, Xi Chen, Evan J Greenawalt, Ujjwal Maulik, Wei Jiang, Zhongming Zhao, Christine M Eischen
Long non-coding RNA (lncRNA) are emerging as contributors to malignancies. Little is understood about the contribution of lncRNA to epithelial-to-mesenchymal transition (EMT), which correlates with metastasis. Ovarian cancer is usually diagnosed after metastasis. Here we report an integrated analysis of >700 ovarian cancer molecular profiles, including genomic data sets, from four patient cohorts identifying lncRNA DNM3OS, MEG3, and MIAT overexpression and their reproducible gene regulation in ovarian cancer EMT...
November 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29149775/lentiviral-vectors-and-adeno-associated-virus-vectors-useful-tools-for-gene-transfer-in-pain-research
#6
REVIEW
Zheng Chen-Xi, Wang Sheng-Ming, Bai Yun-Hu, Luo Ting-Ting, Wang Jia-Qi, Dai Chun-Qiu, Guo Bao-Lin, Luo Shi-Cheng, Wang Dong-Hui, Yang Yan-Ling, Wang Ya-Yun
Pain, especially chronic pain, has always been a heated point in both basic and clinical researches since it puts heavy burdens on both individuals and the whole society. A better understanding of the role of biological molecules and various ionic channels involved in pain can shed light on the mechanism under pain and advocate the development of pain management. Using viral vectors to transfer specific genes at targeted sites is a promising method for both research and clinical applications. Lentiviral vectors and adeno-associated virus (AAV) vectors which allow stable and long-term expression of transgene in non-dividing cells are widely applied in pain research...
November 17, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29149529/scalable-fabrication-of-highly-active-and-durable-membrane-electrodes-toward-water-oxidation
#7
Yu Li, Shuangming Chen, Dawei Xi, Yanan Bo, Ran Long, Chengming Wang, Li Song, Yujie Xiong
The electrocatalytic oxygen evolution reaction (OER) is a highly important reaction that requires a relatively high overpotential and determines the rate of water splitting-a process for producing hydrogen. The overall OER performance is often largely limited by uncontrollable interface when active catalysts are loaded on conductive supports, for which polymer binders are widely used, but inevitably block species transportation channels. Here, a scalable fabrication approach to freestanding graphitized carbon nanofiber networks is reported, which provides abundant sites for in situ growing Fe/Ni catalysts with the improved interface...
November 17, 2017: Small
https://www.readbyqxmd.com/read/29149172/spectroscopic-characterization-of-dom-and-the-nitrogen-removal-mechanism-during-wastewater-reclamation-plant
#8
Lei Wang, Ying-Jun Li, Ying Xiong, Wen-Bing Tan, Lie-Yu Zhang, Xiang Li, Xiao-Shu Wang, Jian-Feng Xu, Tong-Tong Li, Jin-Sheng Wang, Ming-Xuan Cai, Bei-Dou Xi, Di-Hua Wang
The performance of the Sha-he wastewater reclamation plant was evaluated in this study. To remove residual nitrogen after Anaerobic-Anoxic-Oxic (A2O) treatment, three multistage Anoxic-Oxic (A/O) were added to investigate the nitrogen removal efficiency and its mechanism. In addition, the constituents and evolution of dissolved organic matter (DOM) during wastewater reclamation was also investigated using a method combining fluorescence spectroscopy with fluorescence regional integration (FRI). The results suggested that multistage A/O treatment can effectively improve the nitrogen removal ability under low concentrations of carbon sources...
2017: PloS One
https://www.readbyqxmd.com/read/29149053/laser-induced-breakdown-spectroscopy-for-rapid-discrimination-of-heavy-metal-contaminated-seafood-tegillarca-granosa
#9
Guoli Ji, Pengchao Ye, Yijian Shi, Leiming Yuan, Xiaojing Chen, Mingshun Yuan, Dehua Zhu, Xi Chen, Xinyu Hu, Jing Jiang
Tegillarca granosa samples contaminated artificially by three kinds of toxic heavy metals including zinc (Zn), cadmium (Cd), and lead (Pb) were attempted to be distinguished using laser-induced breakdown spectroscopy (LIBS) technology and pattern recognition methods in this study. The measured spectra were firstly processed by a wavelet transform algorithm (WTA), then the generated characteristic information was subsequently expressed by an information gain algorithm (IGA). As a result, 30 variables obtained were used as input variables for three classifiers: partial least square discriminant analysis (PLS-DA), support vector machine (SVM), and random forest (RF), among which the RF model exhibited the best performance, with 93...
November 17, 2017: Sensors
https://www.readbyqxmd.com/read/29148783/in-situ-assembly-of-nanoparticles-into-hierarchical-beta-zeolite-with-tailored-simple-organic-molecule
#10
Kai Zhang, Zewei Liu, Xin Yan, Xuelong Hao, Min Wang, Chao Li, Hongxia Xi
A hierarchically structured beta zeolite with intercrystalline mesopores was successfully synthesized via in situ assembly of nanoparticles by employing a simple organic molecule N2-p-N2, tailored form polyquaternium surfactant, with no hydrophobic long chain. The obtained material was characterized by powder X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM), nitrogen adsorption/desorption isotherms and computer simulation. These results indicated that the tailored template molecule N2-p-N2 without hydrophobic long chain tail still can direct the zeolite crystallization, the hydrophobic long chain tail is not necessary during the mesoporous Beta zeolite formation...
November 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29147871/an-optimized-and-feasible-preparation-technique-for-the-industrial-production-of-hydrogel-patches
#11
Wei-Ze Li, Wen-Xia Han, Xu-Liang Hao, Ning Zhao, Xi-Feng Zhai, Li-Bin Yang, Shu-Miao He, Yu-Chuan Cheng, Han Zhang, Li-Na Fu, Yan Zhang, Ze Liang
For hydrogel patches, the laboratory tests could not fully reveal the existing problems of full scale of industrial production, and there are few studies about the preparation technique for the industrial manufacturing process of hydrogel patches. So, the purpose of this work was to elucidate the effects of mainly technological operation and its parameters on the performance of hydrogel patches at the industrial-scale production. The results revealed the following: (1) the aqueous phase was obtained by polyvinylpyrrolidone (PVP) along with tartaric acid dissolved in purified water, then feeding this into a vacuum mixer as a whole in one batch, thus extended the crosslinking reaction time of hydrogel paste (matrix) and allowed the operation of coating/cutting-off to be carried out easily, and there was no permeation of backing layer; (2) the gel strength of the hydrogel patches increased with the increase of working temperature, however, once the temperature exceeded 35 ± 2 °C, the hydrogel paste would lose water severely and the resultant physical crosslinking structure which has lower gel/cohesive strength would easily bring gelatinization/residues during application; (3) the relative humidity (RH) of the standing-workshop was dynamically controlled (namely at 35 ± 2 °C, keeping the RH at 55 ± 5% for 4 days, then 65 ± 5% for 2 days), which would make patches with satisfactory characteristics such as better flexibility, higher adhesive force, smooth flat matrix surface, and without gelatinization/residues and warped edge during the using process; (4) the aging of the packaged hydrogel patches was very sensitive to storage temperature, higher temperature, higher gel strength and lower adhesiveness...
November 16, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29147510/formation-and-ligand-based-reductive-chemistry-of-bridged-bis-alkylidene-scandium-iii-complexes
#12
Wangyang Ma, Chao Yu, Yue Chi, Tianyang Chen, Lianjun Wang, Jianhao Yin, Baosheng Wei, Ling Xu, Wen-Xiong Zhang, Zhenfeng Xi
The chemistry of rare-earth carbene and alkylidene complexes including their synthesis, structure and reaction is a challenging issue because of their high reactivity (or instability) and the lack of synthetic methods. In this work, we report the first synthesis of the bridged bis-alkylidene complexes which feature a 2-butene-1,1,4,4-tetraanion and four Sc-C(sp(3)) bonds by the reaction of 1,4-dilithio-1,3-butadienes with ScCl3. This reaction proceeds via two key intermediates: an isolable scandacyclopentadiene and a proposed scandacyclopropene...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29146927/preparation-and-functional-evaluation-of-collagen-oligopeptide-rich-hydrolysate-from-fish-skin-with-the-serine-collagenolytic-protease-from-pseudoalteromonas-sp-sm9913
#13
Xiu-Lan Chen, Ming Peng, Jing Li, Bai-Lu Tang, Xuan Shao, Fang Zhao, Chang Liu, Xi-Ying Zhang, Ping-Yi Li, Mei Shi, Yu-Zhong Zhang, Xiao-Yan Song
Although several serine collagenolytic proteases from bacteria were reported, none has been used to prepare bioactive collagen peptides. MCP-01 is the most abundant extracellular protease of deep-sea Pseudoalteromonas sp. SM9913 and is a serine collagenolytic protease with high efficiency on fish collagen hydrolysis. Here, we set up a pilot scale process to ferment SM9913 for extracellular protease production. With SM9913 extracellular protease as a tool, a process to prepare collagen oligopeptide-rich hydrolysate from codfish skin was set up, which was further scaled up to pilot (100 L) and plant (2000 L) levels with yields >66%...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29146732/mir-539-5p-inhibits-experimental-choroidal-neovascularization-by-targeting-cxcr7
#14
Yifan Feng, Jing Wang, Yuanzhi Yuan, Xi Zhang, Minqian Shen, Fei Yuan
Stromal cell-derived factor-1 (SDF-1) has been previously confirmed to participate in the formation of choroidal neovascularization (CNV) via its receptor, CXC chemokine receptor (CXCR) 4; CXCR7 is a recently identified receptor for SDF-1. The molecular mechanisms and therapeutic value of CXCR7 in CNV remain undefined. In this study, experimental CNV was induced by laser photocoagulation in Brown-Norway pigmented rats, and aberrant CXCR7 overexpression was detected in the retinal pigment epithelial/choroid/sclera tissues of laser-injured eyes...
November 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29146720/role-of-mr-neurography-for-the-diagnosis-of-peripheral-trigeminal-nerve-injuries-in-patients-with-prior-molar-tooth-extraction
#15
R Dessouky, Y Xi, J Zuniga, A Chhabra
BACKGROUND AND PURPOSE: Clinical neurosensory testing is an imperfect reference standard to evaluate molar tooth extraction related peripheral trigeminal neuropathy. The purpose was to evaluate the diagnostic accuracy of MR neurography in this domain and correlation with neurosensory testing and surgery. MATERIALS AND METHODS: In this retrospective study, nerve caliber, T2 signal intensity ratio, and contrast-to-noise ratios were recorded by 2 observers using MR neurography for bilateral branches of the peripheral trigeminal nerve, the inferior alveolar and lingual nerves...
November 16, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29146370/characterization-of-lipid-oxidation-process-of-beef-during-repeated-freeze-thaw-by-electron-spin-resonance-technology-and-raman-spectroscopy
#16
Qingmin Chen, Yunfei Xie, Jinzhong Xi, Yahui Guo, He Qian, Yuliang Cheng, Yi Chen, Weirong Yao
In this study, electron spin resonance (ESR) and Raman spectroscopy were applied to characterize lipid oxidation of beef during repeated freeze-thaw (RFT). Besides the conventional indexes including peroxide values (PV), thiobarbituric acid-reactive substances (TBARS) and acid values (AV) were evaluated, the radical and molecular structure changes were also measured by ESR and Raman spectroscopy. The results showed that PV, TBARS and AV were increased (P<0.05) after RFT. This suggested that lipid oxidation was occurred during RFT...
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29146309/stard13-3-untranslated-region-functions-as-a-cerna-for-tp53inp1-in-prohibiting-migration-and-invasion-of-breast-cancer-cells-by-regulating-mir-125b-activity
#17
Lufeng Zheng, Xiaoman Li, Jinjiang Chou, Chenxi Xiang, Qianqian Guo, Zhiting Zhang, Xinwei Guo, Lanlan Gao, Yingying Xing, Tao Xi
Competitive endogenous messenger RNA (ceRNA) affects transcription of other RNA molecules by competitively binding common microRNAs. Previous studies have shown that TP53INP1 functions as a suppressor in tumor metastasis. Our study elucidated StarD13 messenger RNA as a ceRNA in regulating migration and invasion of breast cancer cells. MicroRNA-125b was identified to induce metastasis of MCF-7 cells and bind with both StarD13 3'UTR and TP53INP1 3'UTR. Therefore, a ceRNA interaction between StarD13 and TP53INP1 mediated by competitively binding to miR-125b was indicated...
November 11, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/29146225/response-comparison-of-multiple-myeloma-and-monoclonal-gammopathy-of-undetermined-significance-to-the-same-anti-myeloma-therapy-a-retrospective-cohort-study
#18
John P Campbell, Jennifer L J Heaney, Sankalp Pandya, Zaheer Afzal, Martin Kaiser, Roger Owen, J Anthony Child, David A Cairns, Walter Gregory, Gareth J Morgan, Graham H Jackson, Chris M Bunce, Mark T Drayson
BACKGROUND: Multiple myeloma is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS), which is usually only treated by a form of anti-multiple myeloma therapy if it is causing substantial disease through deposition of secreted M proteins. However, studies comparing how MGUS and multiple myeloma plasma cell clones respond to these therapies are scarce. Biclonal gammopathy multiple myeloma is characterised by the coexistence of an active multiple myeloma clone and a benign MGUS clone, and thus provides a unique model to assess the responses of separate clones to the same anti-multiple myeloma therapy, in the same patient, at the same time...
November 13, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/29145333/risk-factors-and-a-simple-model-for-predicting-bile-leakage-after-radical-hepatectomy-in-patients-with-hepatic-alveolar-echinococcosis
#19
Xianwei Yang, Yiwen Qiu, Wentao Wang, Xi Feng, Shu Shen, Bo Li, Tianfu Wen, Jiayin Yang, Mingqing Xu, Zheyu Chen, Lunan Yan
Postoperative bile leakage (BL) is a major complication of hepatic alveolar echinococcosis (HAE). The purpose of this study was to identify the risk factors for BL and to establish a simple scoring system for predicting BL.A total of 152 patients with HAE were included in the study between May 2004 and December 2016. The patient's baseline data, laboratory blood tests, imaging features, and surgical management were collected. Univariate and multivariate analyses were used to screen for factors to predict BL...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145273/diabetes-mellitus-and-the-risk-of-bladder-cancer-a-prisma-compliant-meta-analysis-of-cohort-studies
#20
Yongping Xu, Rui Huo, Xi Chen, Xuefeng Yu
BACKGROUND: Epidemiologic studies have reported inconsistent results regarding the relationship between diabetes mellitus (DM) and the incidence of bladder cancer. This comprehensive systematic review and meta-analysis explored and evaluated this relationship in participants with different characteristics. METHODS: Studies indexed in the PubMed, Embase, and the Cochrane Library databases that compared bladder cancer incidence mortality between DM and non-DM participants were included in the present study...
November 2017: Medicine (Baltimore)
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