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https://www.readbyqxmd.com/read/28723968/new-library-construction-method-for-single-cell-genomes
#1
Larry Xi, Alexander Belyaev, Sandra Spurgeon, Xiaohui Wang, Haibiao Gong, Robert Aboukhalil, Richard Fekete
A central challenge in sequencing single-cell genomes is the accurate determination of point mutations, phasing of these mutations, and identifying copy number variations with few assumptions. Ideally, this is accomplished under as low sequencing coverage as possible. Here we report our attempt to meet these goals with a novel library construction and library amplification methodology. In our approach, single-cell genomic DNA is first fragmented with saturated transposition to make a primary library that uniformly covers the whole genome by short fragments...
2017: PloS One
https://www.readbyqxmd.com/read/28723874/letter-to-preoperative-radiographic-parameters-to-predict-a-higher-pseudarthrosis-rate-following-anterior-cervical-discectomy-and-fusion
#2
Qiunan Lyu, Xi Yang, ChunGuang Zhou, Yueming Song
No abstract text is available yet for this article.
July 18, 2017: Spine
https://www.readbyqxmd.com/read/28723642/suppression-of-microrna-384-enhances-autophagy-of-airway-smooth-muscle-cells-in-asthmatic-mouse
#3
Zhe Cheng, Xi Wang, Lingling Dai, Liuqun Jia, Xiaogang Jing, Ying Liu, Huan Wang, Pengfei Li, Lin An, Meng Liu
Injury to airway smooth muscle (ASM) cells hallmarks the pathological progression of asthma, a chronic inflammatory airway disease. MicroRNAs (miRNAs) play essential roles in the development of asthma as well as airway remodeling. Here we studied the involvement of miRNAs in the regulation of autophagic survival of ASM cells and airway disorder. We analyzed autophagy-associated factors LC3 and Beclin-1 by RT-qPCR and protein blotting in purified airway smooth muscle cells from ovalbumin (OVA)-induced asthmatic mice...
July 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723627/evaluation-of-hepatectomy-and-palliative-local-treatments-for-gastric-cancer-patients-with-liver-metastases-a-propensity-score-matching-analysis
#4
Jiyang Li, Kecheng Zhang, Yunhe Gao, Hongqing Xi, Jianxin Cui, Wenquan Liang, Aizhen Cai, Bo Wei, Lin Chen
BACKGROUND: The optimal treatments for gastric cancer with liver metastases (GCLM) remain controversial. This study aimed to evaluate the efficacy of hepatectomy, RFA and TACE as local treatments for GCLM. METHODS: From 2001 to 2015, 119 consecutive patients who received multidisciplinary treatments based on curative gastrectomy and local treatments (hepatectomy, RFA and TACE) for liver metastases were enrolled in this retrospective cohort study. Patients were divided into Group A (46, hepatectomy) and Group B (73, either or both RFA and TACE)...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723088/development-of-a-transferable-reactive-force-field-of-p-h-systems-application-to-the-chemical-and-mechanical-properties-of-phosphorene
#5
Hang Xiao, Xiaoyang Shi, Feng Hao, Xiangbiao Liao, Yayun Zhang, Xi Chen
We developed ReaxFF parameters for phosphorus and hydrogen to give a good description of the chemical and mechanical properties of pristine and defected black phosphorene. ReaxFF for P/H is transferable to a wide range of phosphorus and hydrogen containing systems including bulk black phosphorus, blue phosphorene, edge-hydrogenated phosphorene, phosphorus clusters and phosphorus hydride molecules. The potential parameters were obtained by conducting global optimization with respect to a set of reference data generated by extensive ab initio calculations...
July 19, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28723071/maleic-anhydride-labeling-based-approach-for-quantitative-proteomics-and-successive-derivatization-of-peptides
#6
Shanshan Tian, Shuzhen Zheng, Yanpu Han, Zhenchang Guo, Guijin Zhai, Xue Bai, Xi-Wen He, Enguo Fan, YuKui Zhang, Kai Zhang
Chemical derivatization is a simple approach for stable-isotope covalent labeling of proteins in quantitative proteomics. Herein we describe the development of a novel maleyl-labeling-based approach for protein quantification. Under optimized conditions, maleic anhydride can serve as a highly-efficient reagent to label the amino groups of tryptic peptides. Furthermore, 'click chemistry'was successfully applied to obtain the second modification of maleylated peptides via thiol-Michael addition reaction. Accurate quantification was further achieved via the first or/and second step stable-isotope labeling in this study...
July 19, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28722662/antibiotic-prophylaxis-for-infections-in-patients-with-acute-stroke-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#7
Yan-Guo Xi, Xu Tian, Wei-Qing Chen, Sai Zhang, Shan Zhang, Wei-Dan Ren, Qi-Jun Pang, Guo-Tao Yang, Zhi-Ming Yang
OBJECTIVE: Infections are frequent after stroke and lead to increased mortality and neurological disability. Antibiotic prophylaxis has potential of decreasing the risk of infections and mortality and improving poor functional outcome. Several studies evaluated antibiotic prophylaxis for infections in acute stroke patients have generated conflicting results. The systematic review of randomized clinical trials (RCTs) aimed at comprehensively assessing the evidence of antibiotic prophylaxis for the treatment of acute stroke patients...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722473/distribution-and-diversity-of-twelve-curcuma-species-in-china
#8
Lanyue Zhang, Jingwen Wei, Zhiwen Yang, Feng Chen, Qiqiu Xian, Ping Su, Wanyi Pan, Kun Zhang, Xi Zheng, Zhiyun Du
Genus Curcuma a wild species presents an important source of valuable characters for improving the cultivated Curcuma varieties. Based on the collected germplasms, herbariums, field surveys and other literatures, the ecogeographical diversity of Genus Curcuma and its potential distributions under the present and future climate are analysed by DIVA-GIS. The results indicate Genus Curcuma is distributed over 17 provinces in China, and particularly abundant in Guangxi and Guangdong provinces. The simulated current distributions are close to the actual distribution regions...
July 19, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28722405/the-effective-approach-to-promote-proton-conductivity-of-mofs-by-exposure-to-aqua-ammonia-vapor
#9
Xi Liang, Bin Li, Minghao Wang, Jing Wang, Ruilan Liu, Gang Li
We explored proton conductivities of two 3D Co(II) MOFs, {[Co3(m-ClPhIDC)2(H2O)6]·2H2O}n (m-ClPhH3IDC = 2-(m-chlorophenyl)-imidazole-4,5-dicarboxylic acid) (1) and {[Co3(p-ClPhHIDC)3(H2O)3]·6H2O}n (p-ClPhH3IDC = 2-(p-chlorophenyl)-imidazole-4,5-dicarboxylic acid) (2) under water and aqua-ammonia vapors, respectively. The experimental results revealed that the proton conductivities of 1 and 2 at aqua-ammonia vapor were 2.89 × 10-2 S·cm-1 and 4.25 × 10-2 S·cm-1, respectively, and approximately two orders of magnitude greater than those of them at water vapor...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28722330/tunable-biogenic-manganese-oxides
#10
Alexandr Nikolaevich Simonov, Rosalie K Hocking, Lizhi Tao, Thomas Gengenbach, Timothy Williams, Xi-Ya Fang, Hannah J King, Shannon A Bonke, Dijon A Hoogeveen, Christine A Romano, Bradley M Tebo, Lisandra L Martin, William H Casey, Leone Spiccia
Influence of the conditions for aerobic oxidation of Mn2+(aq) catalysed by the MnxEFG protein complex on the morphology, structure and reactivity of the resulting biogenic manganese oxides (MnOx) is explored. Physical characterisation of MnOx includes scanning and transmission electron microscopies, X-ray photoelectron and K-edge Mn, Fe X-ray absorption spectroscopies. This characterisation reveals that the MnOx materials share the structural features of birnessite, yet differ in the degree of structural disorder...
July 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28722223/the-role-of-%C3%AE-adrenergic-receptors-and-p38mapk-signaling-pathways-in-physiological-processes-of-cardiosphere-derived-cells
#11
Wen-Bo Zhang, Yun-Qi Liu, Xi Zhang, Lin Lin, Sheng-Li Yin
The effects of β adrenergic receptors (β-ARs) and p38 mitogen-activated protein kinases (MAPK) pathways on cardiosphere-derived cells (CDCs) are largely unknown. This study aimed to investigate the roles of β-ARs and p38MAPK pathways on the proliferation, apoptosis and differentiation capacity of CDCs. The CDCs were treated with β1-AR blocker (Met group), β2-AR antagonist (ICI group) and p38MAPK inhibitor (SB group), nonselective β-AR blocker (PRO group), and β-AR agonist (ISO group). The viability, apoptotic rate and differentiation status of CDCs were determined by MST-1 assay, flow cytometery, and Western blot, respectively...
July 19, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28721681/genetic-characterization-and-disease-mechanism-of-retinitis-pigmentosa-current-scenario
#12
REVIEW
Muhammad Umar Ali, Muhammad Saif Ur Rahman, Jiang Cao, Ping Xi Yuan
Retinitis pigmentosa is a group of genetically transmitted disorders affecting 1 in 3000-8000 individual people worldwide ultimately affecting the quality of life. Retinitis pigmentosa is characterized as a heterogeneous genetic disorder which leads by progressive devolution of the retina leading to a progressive visual loss. It can occur in syndromic (with Usher syndrome and Bardet-Biedl syndrome) as well as non-syndromic nature. The mode of inheritance can be X-linked, autosomal dominant or autosomal recessive manner...
August 2017: 3 Biotech
https://www.readbyqxmd.com/read/28721567/modified-double-layer-anastomosis-for-minimally-invasive-esophagectomy-an-effective-way-to-prevent-leakage-and-stricture
#13
Yong Yuan, Xiao-Xi Zeng, Yong-Fan Zhao, Long-Qi Chen
BACKGROUND: Anastomotic leakage and stricture contribute to a large number of mortality and morbidity after esophagectomy. The aim of this work is to evaluate the outcome of modified double-layer hand-sewn esophagogastric anastomosis during minimally invasive esophagectomy for esophageal cancer. METHODS: The clinicopathological data of 176 consecutive esophageal cancer patients who underwent cervical esophagogastric anastomosis using modified double-layer hand-sewn technique after radical esophagectomy were retrospectively reviewed...
July 18, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28721411/power-output-and-carrier-dynamics-studies-of-perovskite-solar-cells-under-working-conditions
#14
Man Yu, Hao-Yi Wang, Ming-Yang Hao, Yujun Qin, Li-Min Fu, Jian-Ping Zhang, Xi-Cheng Ai
Perovskite solar cells have emerged as promising photovoltaic systems with superb power conversion efficiency. For the practical application of perovskite devices, the greatest concerns are the power output density and the related dynamics under working conditions. In this study, the working conditions of planar and mesoscopic perovskite solar cells are simulated and the power output density evolutions with the working voltage are highlighted. The planar device exhibits higher capability of outputting power than the mesoscopic one...
July 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28721070/association-of-estrogen-receptor-%C3%AE-pvuii-and-xbai-polymorphisms-with-prostate-cancer-susceptibility-and-risk-stratification-a-meta-analysis-from-case-control-studies
#15
Yining Zhao, Xi Zheng, Lijie Zhang, Qiang Hu, Yitian Guo, Hua Jiang, Shennan Shi, Xiang Zhang
BACKGROUND: Studies on the association between two single nucleotide polymorphisms (SNPs) in estrogen receptor α (ERα), PvuII (rs2234693 T>C) and XbaI (rs9340799 A>G), and the prostate cancer risk are inconsistent. Therefore, we performed a meta-analysis to derive a more accurate estimation of this relationship. METHODS: A literature search of PubMed, Embase, Web of Science databases until October 1, 2016, was conducted. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of this association...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28720548/pxapn5-serves-as-a-functional-receptor-of-cry2ab-in-plutella-xylostella-l-and-its-binding-domain-analysis
#16
Zhi-Zhen Pan, Lian Xu, Bo Liu, Jing Zhang, Zheng Chen, Qing-Xi Chen, Yu-Jing Zhu
Lepidopteran midgut aminopeptidases N (APNs) are widely studied for their potential roles as one of the receptors for the Bacillus thuringiensis (Bt) crystal insecticidal toxins. In the present study, a loss of function analyses by RNAi (RNA interference) silencing of the Plutella xylostella APN5 (PxAPN5), a binding protein of Cry2Ab, were performed. The knocking down of PxAPN5 in P. xylostella larvae greatly reduced their susceptibility to Cry2Ab and led to a decrease of Cry2Ab binding to P. xylostella midgut...
July 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28719959/pcr-identification-and-phylogenetic-analysis-of-trichomonas-gallinae-from-domestic-pigeons-in-guangzhou-china
#17
Shen-Ben Qiu, Meng-Na Lv, Xi He, Ya-Biao Weng, Shang-Shu Zou, Xin-Qiu Wang, Rui-Qing Lin
Avian trichomoniasis caused by Trichomonas gallinae is a serious protozoan disease worldwide. The domestic pigeon (Columba livia domestica) is the main host for T. gallinae and plays an important role in the spread of the disease. Based on the internal transcribed spacers of nuclear ribosomal DNA of this parasite, a pair of primers (TgF2/TgR2) was designed and used to develop a PCR assay for the diagnosis of T. gallinae infection in domestic pigeons. This approach allowed the identification of T. gallinae, and no amplicons were produced when using DNA from other common avian pathogens...
June 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28719327/extensive-resistance-of-anopheles-sinensis-to-insecticides-in-malaria-endemic-areas-of-hainan-province-china
#18
Ding-Wei Sun, Guang-Ze Wang, Lin-Hai Zeng, Shan-Gan Li, Chang-Hua He, Xi-Min Hu, Shan-Qing Wang
Anopheles sinensis is one of the major malaria vectors and among the dominant species in Hainan Province, China. The resistance of An. sinensis to insecticides is an important threat to malaria control. However, few reports on insecticide resistance of An. sinensis were reported in this area. Eight districts in Hainan Province were selected as the study areas. Insecticide susceptibility bioassays were tested on wild-caught female mosquitoes of An. sinensis to 4% dichlorodiphenyltrichloroethane (DDT), 0.05% deltamethrin, and 5% malathion by using the World Health Organization standard resistance tube assay procedure...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719148/high-expression-of-fundc1-predicts-poor-prognostic-outcomes-and-is-a-promising-target-to-improve-chemoradiotherapy-effects-in-patients-with-cervical-cancer
#19
Hailing Hou, Puchun Er, Jingjing Cheng, Xiuli Chen, Xiaofeng Ding, Yuwen Wang, Xi Chen, Zhiyong Yuan, Qingsong Pang, Ping Wang, Dong Qian
FUN14 domain containing 1 (FUNDC1) is an important molecule in receptor-dependent mitophagy. However, the roles of FUNDC1 in human cancer biology remain unknown. The aim of this study was to explore the expression and roles of FUNDC1 in cervical cancer. Immunohistochemistry and Western blotting were applied to detect the expression of FUNDC1, and small-hairpin RNA was applied to inhibit the expression of endogenous FUNDC1 in cervical cancer cells. MTT assays and Flow cytometric analysis were applied to examine cell proliferation and apoptosis...
July 18, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28718279/complex-annulations-through-silver-carbenoid-intermediate-an%C3%A2-alternative-entry-to-transformations-of-1-2-3-triazoles
#20
Yuan Yang, Jiang-Xi Yu, Xuan-Hui Ouyang, Jin-Heng Li
An alternative entry to transformations of N-sulfonyl-4-(2-(ethynyl)aryl)-1,2,3-triazoles with various generated in situ or external nucleophiles by means of silver catalysis for producing diverse functionalized isoquinolines is described. Mechanistically, the reaction is proposed to involve a key silver carbenoid intermediate, thus enabling the formation of multiple chemical bonds via ring opening, N2 extrusion, silver carbenoid formation, nucleophilic addition, and complex annulations cascades.
July 18, 2017: Organic Letters
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