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https://www.readbyqxmd.com/read/28926834/heme-oxygenase-activity-and-heme-binding-in-a-neonatal-mouse-model
#1
Stephanie Kourula, Joyce Ang, Hui Zhao, Flora Kalish, Peter Vandenabeele, Karl G Sylvester, Ronald J Wong, David K Stevenson
BACKGROUND: Severe hemolytic disease of the newborn leads to the release of pro-oxidative free heme (FH). Heme oxygenase (HO) is primarily responsible for detoxifying FH. OBJECTIVE: To investigate the protective effects of HO in a model of heme overload. METHODS: For in vitro studies, NIH3T3 HO-1-luc cells were incubated with 10, 30, or 60 µM FH or methemalbumin (MHA). HO-1 promoter activity was assessed 3, 6, and 24 h after treatment. Cell survival was indexed by viability assays...
September 20, 2017: Neonatology
https://www.readbyqxmd.com/read/28926828/are-all-amplitude-integrated-electroencephalogram-systems-equal
#2
Tobias Werther, Monika Olischar, Gunnar Naulaers, Philipp Deindl, Katrin Klebermass-Schrehof, Nathan Stevenson
BACKGROUND: Filter and peak detection algorithms implemented in amplitude-integrated electroencephalogram (aEEG) systems are not standardized. New aEEG systems are continuously enriching the market and clinicians are faced with different aEEG devices whose tracings may vary. OBJECTIVES: The aim of this work was to determine the role of different aEEG systems on quantitative measurements of the aEEG. METHODS: In this observational study, a single-channel aEEG recording (Olympic CFM 6000) with corresponding EEG signal was obtained from 32 infants at a gestational age of 36-44 weeks...
September 20, 2017: Neonatology
https://www.readbyqxmd.com/read/28926371/residential-agricultural-pesticide-exposures-and-risks-of-spontaneous-preterm-birth
#3
Gary M Shaw, Wei Yang, Eric M Roberts, Susan E Kegley, David K Stevenson, Suzan L Carmichael, Paul B English
BACKGROUND: Pesticides exposures are aspects of the human exposome that have not been sufficiently studied for their contribution to risk for preterm birth. We investigated risks of spontaneous preterm birth from potential residential exposures to 543 individual chemicals and 69 physicochemical groupings that were applied in the San Joaquin Valley of California during the study period, 1998-2011. METHODS: The study population was derived from birth certificate data linked with Office of Statewide Health Planning and Development maternal and infant hospital discharge data...
September 18, 2017: Epidemiology
https://www.readbyqxmd.com/read/28922925/preface-to-the-fundamental-interfacial-science-for-energy-applications-special-issue
#4
Keith J Stevenson, Debra R Rolison, Richard M Crooks
No abstract text is available yet for this article.
September 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28913709/unprecedented-anticancer-activities-of-organorhenium-sulfonato-and-carboxylato-complexes-against-hormone-dependent-mcf-7-and-hormone-independent-triple-negative-mda-mb-231-breast-cancer-cells
#5
Paul T Wilder, David J Weber, Angela Winstead, Sabreea Parnell, Tiara V Hinton, Monet Stevenson, Dipak Giri, Samira Azemati, Pola Olczak, Brent V Powell, Tijesunimi Odebode, Solomon Tadesse, Yongchao Zhang, Saroj K Pramanik, James M Wachira, Sujan Ghimire, Pumtiwitt McCarthy, Alexis Barfield, Hirendra N Banerjee, Chao Chen, James A Golen, Arnold L Rheingold, Jeanette A Krause, Douglas M Ho, Peter Y Zavalij, Roosevelt Shaw, Santosh K Mandal
Cisplatin and other metal-based drugs often display side effects and tumor resistance after prolonged use. Because rhenium-based anticancer complexes are often less toxic, a novel series of organorhenium complexes were synthesized of the types: XRe(CO)3Z (X = α-diimines and Z = p-toluenesulfonate, 1-naphthalenesulfonate, 2-naphthalenesulfonate, picolinate, nicotinate, aspirinate, naproxenate, flufenamate, ibuprofenate, mefenamate, tolfenamate, N-acetyl-tryptophanate), and their biological properties were examined...
September 14, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28911205/a-zebrafish-model-of-x-linked-adrenoleukodystrophy-recapitulates-key-disease-features-and-demonstrates-a-developmental-requirement-for-abcd1-in-oligodendrocyte-patterning-and-myelination
#6
Lauren R Strachan, Tamara J Stevenson, Briana Freshner, Matthew D Keefe, D Miranda Bowles, Joshua L Bonkowsky
X-linked adrenoleukodystrophy (ALD) is a devastating inherited neurodegenerative disease caused by defects in the ABCD1 gene and affecting peripheral and central nervous system myelin. ABCD1 encodes a peroxisomal transmembrane protein required for very long chain fatty acid (VLCFA) metabolism. We show that zebrafish (Danio rerio) Abcd1 is highly conserved at the amino acid level with human ABCD1, and during development is expressed in homologous regions including the central nervous system and adrenal glands...
September 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28910733/survey-of-the-effect-of-odour-impact-on-communities
#7
J E Hayes, R J Stevenson, R M Stuetz
In the context of environmental malodour, surveys are valuable as they allow for the relatively detailed analysis of multiple factors pertaining to odour perception and subsequent reaction. However, the causes for an individual to experience odour impact while a neighbour will not are still not understood. The goal of this current survey design was to consolidate varying research paths for surveys within the environmental odour research space. This survey investigated the area of effect for wastewater treatment plants by using stratified random sampling techniques that radiated from the industrial areas...
September 11, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28910319/chronic-social-defeat-induces-long-term-behavioral-depression-of-aggressive-motivation-in-an-invertebrate-model-system
#8
Jacqueline Rose, Jan Rillich, Paul A Stevenson
Losing a fight against a conspecific male (social defeat) induces a period of suppressed aggressiveness and general behaviour, often with symptoms common to human psychiatric disorders. Agonistic experience is also discussed as a potential cause of consistent, behavioral differences between individuals (animal "personality"). In non-mammals, however, the impact of single agonistic encounters typically last only hours, but then again studies of repeated intermittent defeat (chronic social defeat) are seldom...
2017: PloS One
https://www.readbyqxmd.com/read/28904198/type-1-interferon-signalling-to-dendritic-cells-limits-murid-herpesvirus-4-spread-from-the-olfactory-epithelium
#9
Clara Lawler, Philip G Stevenson
Murid Herpesvirus-4 (MuHV-4) is a B cell-tropic gamma-herpesvirus that can be studied in vivo Despite viral evasion, type 1 interferons (IFN-I) limit its spread. After MuHV-4 inoculation into footpads, IFN-I protect lymph node subcapsular sinus macrophages (SSM) against productive infection; after peritoneal inoculation, they protect splenic marginal zone macrophages; and they limit MuHV-4 replication in the lungs. While invasive infections can test specific aspects of host colonization, it is important also to understand natural infection...
September 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28904056/simultaneously-monitoring-immune-response-and-microbial-infections-during-pregnancy-through-plasma-cfrna-sequencing
#10
Wenying Pan, Thuy T M Ngo, Joan Camunas-Soler, Chun-Xiao Song, Mark Kowarsky, Yair J Blumenfeld, Ronald J Wong, Gary M Shaw, David K Stevenson, Stephen R Quake
BACKGROUND: Plasma cell-free RNA (cfRNA) encompasses a broad spectrum of RNA species that can be derived from both human cells and microbes. Because cfRNA is fragmented and of low concentration, it has been challenging to profile its transcriptome using standard RNA-seq methods. METHODS: We assessed several recently developed RNA-seq methods on cfRNA samples. We then analyzed the dynamic changes of both the human transcriptome and the microbiome of plasma during pregnancy from 60 women...
September 13, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28901160/development-of-a-plug-and-play-immunopcr-technique-for-the-analysis-of-biomolecules
#11
Sreeja Gopal, Shobha Purushothama, Alvydas Mikulskis, Lauren Stevenson
AIM: ImmunoPCR technology combines the advantages of specificity and robustness of a ligand binding assay with the amplification potential of PCR. We describe through three case studies a plug-and-play immuno polymerase chain reaction (iPCR) technique to measure biomolecules. RESULTS: Case Study 1 demonstrated feasibility of measurement of IgG1 in cerebrospinal fluid at the desired level of sensitivity with minimal cost and timelines of clinical assay implementation...
September 13, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28893972/cross-sectional-study-of-antimicrobials-used-for-surgical-prophylaxis-by-bovine-veterinary-practitioners-in-australia
#12
Laura Y Hardefeldt, Glen F Browning, Karin A Thursky, James R Gilkerson, Helen Billman-Jacobe, Mark A Stevenson, Kirsten E Bailey
Antimicrobials are widely used in veterinary practices, but there has been no investigation of antimicrobial classes used or the appropriateness of their use in bovine practice. This study investigated antimicrobial use for surgical prophylaxis in bovine practice in Australia. A cross-sectional study of veterinarian antimicrobial usage patterns was conducted using an online questionnaire. Information solicited included respondent's details, the frequency with which antimicrobials were used for specific surgical conditions (including the dose, timing and duration of therapy) and details of practice antimicrobial use policies and sources of information about antimicrobials...
September 11, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28888652/erratum-to-antimicrobials-used-for-surgical-prophylaxis-by-companion-animal-veterinarians-in-australia-vet-microbiol-203c-2017-301-307
#13
Laura Y Hardefeldt, Glenn F Browning, Karin Thursky, James R Gilkerson, Helen Billman-Jacobe, Mark A Stevenson, Kirsten E Bailey
No abstract text is available yet for this article.
September 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28888074/early-recovery-of-circulating-immature-b-cells-in-b-lymphoblastic-leukemia-patients-after-cd19-targeted-car-t-cell-therapy-a-pitfall-for-minimal-residual-disease-detection
#14
Wenbin Xiao, Dalia Salem, Catherine McCoy, Daniel Lee, Nirali N Shah, Maryalice Stetler-Stevenson, Constance M Yuan
BACKGROUND: CD19-targeted chimeric-antigen receptor-modified T-cells (CAR-T) are promising in the treatment of refractory B-lymphoblastic leukemia (B-ALL). Minimal residual disease (MRD) detection by multicolor flow cytometry (FCM) is critical to distinguish B-ALL MRD from regenerating, non-neoplastic B-cell populations. METHODS: FCM was performed on samples from 9 patients with B-ALL treated with CAR-T. RESULTS: All 9 patients showed response to CAR-T...
September 9, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28886626/observation-of-the-de-vries-behavior-in-sma-phase-of-a-liquid-crystal-using-polarised-raman-scattering-and-infrared-spectroscopy
#15
A Kocot, J K Vij, T S Perova, K Merkel, V Swaminathan, S P Sreenilayam, N Yadav, V P Panov, P J Stevenson, A Panov, D Rodriguez-Lojo
Two approaches exist in the literature for describing the orientational distribution function (ODF) of the molecular directors in SmA* phase of liquid crystals, though several models are recently proposed in the literature for explaining the de Vries behaviour. These ODFs correspond to either the conventional unimodal arrangements of molecular directors arising from the mean field theory that leads to the broad or sugar-loaf like distribution or to the "diffuse-cone-shaped" type distribution proposed by de Vries...
September 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28882239/bridge-to-transplantation-advanced-heart-failure-and-transplant%C3%A2-cardiology-training-for-cardiovascular%C3%A2-disease%C3%A2-fellows
#16
EDITORIAL
Kamesh Sivagnanam, Lisa A Mendes, Kelly H Schlendorf, Julie B Damp, Lynne W Stevenson, Vijay Ramu, Mary N Walsh, Mariell Jessup, JoAnn Lindenfeld
No abstract text is available yet for this article.
September 12, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28881068/molecular-genetics-of-syndromic-and-non-syndromic-forms-of-parathyroid-carcinoma
#17
REVIEW
Luís Cardoso, Mark Stevenson, Rajesh V Thakker
Parathyroid carcinoma (PC) may occur as part of a complex hereditary syndrome or an isolated (i.e. non-syndromic) non-hereditary (i.e. sporadic) endocrinopathy. Studies of hereditary, and syndromic forms of PC, which include the hyperparathyroidism-jaw tumour syndrome (HPT-JT), multiple endocrine neoplasia types 1 and 2 (MEN1 and MEN2), and familial isolated primary hyperparathyroidism (FIHP), have revealed some genetic mechanisms underlying PC. Thus, cell division cycle 73 (CDC73) germline mutations cause HPT-JT, and CDC73 mutations occur in 70% of sporadic PC, but in only ∼2% of parathyroid adenomas...
September 7, 2017: Human Mutation
https://www.readbyqxmd.com/read/28880435/thrombocytopenia-and-cd34-expression-is-decoupled-from-%C3%AE-granule-deficiency-with-mutation-of-the-first-gfi1b-zinc-finger
#18
D J Rabbolini, M-C Morel-Kopp, Q Chen, S Gabrielli, L C Dunlop, L P Chew, N Blair, T A Brighton, N Singh, A P Ng, C M Ward, W S Stevenson
BACKGROUND: Mutation of the GFI1B fifth DNA-binding zinc-finger domain causes macrothrombocytopenia and α-granule deficiency leading to clinical bleeding. The phenotypes associated with GFI1B variants disrupting non-DNA-binding zinc-fingers remain uncharacterized. OBJECTIVES: To determine the functional and phenotypic consequences of GFI1B variants disrupting non-DNA-binding zinc-finger domains. METHODS: The GFI1B C168F variant and a novel GFI1B c...
September 7, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28879021/diamond-digital-alcohol-management-on-demand-a-mixed-methods-feasibility-rct-and-embedded-process-evaluation-of-a-digital-health-intervention-to-reduce-hazardous-and-harmful-alcohol-use
#19
Fiona L Hamilton, Jo Hornby, Jessica Sheringham, Stuart Linke, Charlotte Ashton, Kevin Moore, Fiona Stevenson, Elizabeth Murray
BACKGROUND: Alcohol is a major risk factor for preventable illness, with huge cost to healthcare economies. There is a role for alcohol-specific digital health interventions (DHI), but there have been few randomised controlled trials (RCT) comparing DHI with face-to-face treatment. Such trials are complex and face obstacles in recruitment and retention. METHODS: Mixed-methods feasibility RCT of an alcohol DHI, testing recruitment, online data-collection and randomisation processes, with an embedded process evaluation...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28876659/abdominoperineal-resection-in-the-prone-position-early-outcomes-at-a-tertiary-institution-in-the-western-cape-south-africa
#20
N Stevenson, A V V Lambrechts
BACKGROUND: Abdominoperineal resection (APR) in the prone position is a new technique in the developing world, where colorectal cancer incidence is rising fast and the patient population is different from those in the developed world. Literature is lacking on the outcomes of this technique under these conditions. METHOD: All patients who underwent APR in the prone position for rectal adenocarcinoma from February 2011 to February 2017 were reviewed. Main endpoints were stage at presentation, neoadjuvant treatment, circumferential resection margin involvement, perineal wound complications, length of intensive care unit (ICU) stay and days discharged after surgery...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
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