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https://www.readbyqxmd.com/read/29687822/probing-the-nanoparticle-ago2-interaction-for-enhanced-gene-knockdown
#1
Sonal Deshpande, Neetu Singh
RNAi is emerging as a promising technology for treatment of various diseases due to its ability to silence specific target genes. To date, a number of nanoparticle based formulations have been reported for the delivery of small interfering RNA (siRNA), with continuous modifications in the nanoparticle design for enhancing their efficiency. While majority of the design aspects are focused on avoiding or overcoming endosomal entrapment, limited studies are available that address the role of interaction of nanoparticles with the RNA induced silencing complex (RISC) machinery, which is a crucial aspect deciding the outcome...
April 24, 2018: Soft Matter
https://www.readbyqxmd.com/read/29678364/surgeons-assessment-versus-risk-models-for-predicting-complications-of-hepato-pancreato-biliary-surgery-hpb-risc-a-multicenter-prospective-cohort-study
#2
Morsal Samim, Timothy H Mungroop, Mohammed AbuHilal, Cas J Isfordink, Quintus I Molenaar, Marcel J van der Poel, Thomas A Armstrong, Arjun S Takhar, Neil W Pearce, John N Primrose, Scott Harris, Helena M Verkooijen, Thomas M van Gulik, Jeroen Hagendoorn, Olivier R Busch, Colin D Johnson, Marc G Besselink
BACKGROUND: Several studies advise the use of risk models when counseling patients for hepato-pancreato-biliary (HPB) surgery, but studies comparing these models to the surgeons' assessment are lacking. The aim of this study was to assess whether risk prediction models outperform surgeons' assessment for the risk of complications in HPB surgery. METHODS: This prospective study included adult patients scheduled for HPB surgery in three centers in the UK and the Netherlands...
April 17, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29677827/study-of-phenoxaborin-derivatives-for-thermally-activated-delayed-fluorescence-emitters
#3
Geon Hyeong Lee, Young Sik Kim
Novel thermally activated delayed fluorescence (TADF) materials including 10H-phenoxaborin (PXB) as an electron acceptor and carbazole derivatives [carbazole (Cz), 1-methyl-carbazole (1-m-Cz), and 3,6-bis(3,6-diphenylcarbazolyl)carbazole (BDPCC)] as electron donors (Cz-PXB, 1-m-Cz-PXB, and BDPCC-PXB) were designed and investigated theoretically for deep blue organic light-emitting diode (OLED). Using density functional theory (DFT) and time-dependent DFT calculations, we obtained the electron distribution of the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) and the energy of the lowest singlet (S1) and the lowest triplet (T1) excited states...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29675166/dual-emissive-2-2-hydroxyphenyl-oxazoles-for-high-performance-organic-electroluminescent-devices-discovery-of-a-new-equilibrium-of-excited-state-intramolecular-proton-transfer-with-a-reverse-intersystem-crossing-process
#4
Bijin Li, Linsen Zhou, Hu Cheng, Quan Huang, Jingbo Lan, Liang Zhou, Jingsong You
The photoluminescence (PL) and electroluminescence (EL) properties of two highly efficient excited state intramolecular proton transfer (ESIPT) molecules, 2-(2'-hydroxyphenyl)oxazoles containing one triphenylamine (TPA) ( 1 ) and two TPAs ( 2 ) respectively, are studied systematically. The enol-forms of both 1 and 2 possess highly hybridized local and charge transfer (HLCT) excited state character, while their excited-state keto-forms are not of obvious HLCT character. A 1 -based device exhibits green-white electroluminescence with Commission Internationale d'Eclairage (CIE) coordinates of (0...
February 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29660014/igf2bp1-enhances-an-aggressive-tumor-cell-phenotype-by-impairing-mirna-directed-downregulation-of-oncogenic-factors
#5
Simon Müller, Nadine Bley, Markus Glaß, Bianca Busch, Vanessa Rousseau, Danny Misiak, Tommy Fuchs, Marcell Lederer, Stefan Hüttelmaier
The oncofetal IGF2 mRNA binding proteins (IGF2BPs) are upregulated in most cancers but their paralogue-specific roles in tumor cells remain poorly understood. In a panel of five cancer-derived cell lines, IGF2BP1 shows highly conserved oncogenic potential. Consistently, the deletion of IGF2BP1 impairs the growth and metastasis of ovarian cancer-derived cells in nude mice. Gene expression analyses in ovarian cancer-derived cells reveal that the knockdown of IGF2BPs is associated with the downregulation of mRNAs that are prone to miRNA regulation...
April 12, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29642507/a-fiber-bragg-grating-interrogation-system-with-self-adaption-threshold-peak-detection-algorithm
#6
Weifang Zhang, Yingwu Li, Bo Jin, Feifei Ren, Hongxun Wang, Wei Dai
A Fiber Bragg Grating (FBG) interrogation system with a self-adaption threshold peak detection algorithm is proposed and experimentally demonstrated in this study. This system is composed of a field programmable gate array (FPGA) and advanced RISC machine (ARM) platform, tunable Fabry-Perot (F-P) filter and optical switch. To improve system resolution, the F-P filter was employed. As this filter is non-linear, this causes the shifting of central wavelengths with the deviation compensated by the parts of the circuit...
April 8, 2018: Sensors
https://www.readbyqxmd.com/read/29615048/measurement-properties-of-the-nepali-version-of-the-connor-davidson-resilience-scales-in-individuals-with-chronic-pain
#7
Saurab Sharma, Anupa Pathak, J Haxby Abbott, Mark P Jensen
BACKGROUND: Resilience is an individual's ability to recover or "bounce back" from stressful events. It is commonly identified as a protective factor against psychological dysfunctions in wide range of clinical conditions including chronic pain. Resilience is commonly assessed using the Connor Davidson Resilience Scale (CD-RISC). Translation and cross-cultural adaptation of the CD-RISC into Nepali will allow for a deeper understanding of resilience as an important domain in health in Nepal, and will allow for cross-cultural comparison with other cultures...
April 3, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29589794/adding-a-parent-to-the-brain-tumor-team-evaluating-a-peer-support-intervention-for-parents-of-children-with-brain-tumors
#8
Mary Baron Nelson, Kathy Riley, Kimberly Arellano
Childhood brain tumors often present profound challenges to patients and families. To address these challenges, the California Chapter of the Pediatric Brain Tumor Foundation provides hospital-based support services to parents of children with brain tumors from a Veteran Parent (VP). This mixed-methods, cross-sectional study was designed to evaluate the effectiveness of the intervention using validated tools to compare parental resilience and impact of illness on the family between parents who met with the VP and those who did not...
March 1, 2018: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/29589750/argonaute-facilitates-the-lateral-diffusion-of-guide-along-its-target-and-prevents-guide-from-being-pushed-away-by-ribosome
#9
Guangtao Song, Hui Chen, Gang Sheng, Yanli Wang, Jizhong Lou
Argonaute (AGO) proteins play central roles in nucleic acid-guided interferences that regulate gene expression and defend against foreign genetic elements in all life. Although much progress has been made on the function of argonaute proteins in target recognition and cleavage, the detailed mechanism of their biological functions is not fully under-stood. Here, using AFM-based single-molecule force spectroscopy, we studied the target-guide dissociation in the absence or presence of Thermus thermophiles AGO (TtAGO)...
March 28, 2018: Biochemistry
https://www.readbyqxmd.com/read/29579276/contributions-of-mean-and-shape-of-blood-pressure-distribution-to-worldwide-trends-and-variations-in-raised-blood-pressure-a-pooled-analysis-of-1018-population-based-measurement-studies-with-88-6-million-participants
#10
(no author information available yet)
Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure...
March 19, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29564952/cerebrospinal-fluid-chitinase-3-like-protein-1-level-is-not-an-independent-predictive-factor-for-the-risk-of-clinical-conversion-in-radiologically-isolated-syndrome
#11
Eric Thouvenot, Geoffrey Hinsinger, Christophe Demattei, Ugur Uygunoglu, Giovanni Castelnovo, Sophie Pittion-Vouyovitch, Darin Okuda, Orhun Kantarci, Daniel Pelletier, Sylvain Lehmann, Philippe Marin, Aksel Siva, Christine Lebrun
BACKGROUND: Younger age, male sex and presence of spinal cord lesion(s) increase the risk of conversion from radiologically isolated syndrome (RIS) to relapsing-remitting multiple sclerosis (RRMS). Elevated cerebrospinal fluid (CSF) chitinase-3-like protein 1 (CHI3L1) levels predict conversion from clinically isolated syndrome (CIS) to RRMS. OBJECTIVE: To evaluate the prognostic value of CSF CHI3L1 in RIS patients for conversion to RRMS. METHODS: We compared CSF CHI3L1 concentrations in RIS, CIS, RRMS and symptomatic controls (SCs)...
March 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29538456/a-trauma-network-with-centralized-and-local-health-care-structures-evaluating-the-effectiveness-of-the-first-certified-trauma-network-of-the-german-society-of-trauma-surgery
#12
Antonio Ernstberger, Michael Koller, Florian Zeman, Maximilian Kerschbaum, Franz Hilber, Eva Diepold, Julika Loss, Tanja Herbst, Michael Nerlich
BACKGROUND: Trauma is a global burden of disease and one of the main causes of death worldwide. Therefore, many countries around the world have implemented a wide range of different initiatives to minimize mortality rates after trauma. One of these initiatives is the bundling of treatment expertise in trauma centers and the establishment of trauma networks. Germany has a decentralized system of trauma care medical centers. Severely injured patients ought to receive adequate treatment in both level I and level II centers...
2018: PloS One
https://www.readbyqxmd.com/read/29519815/structural-and-functional-analyses-reveal-the-contributions-of-the-c-and-n-lobes-of-argonaute-protein-to-selectivity-of-rna-target-cleavage
#13
Daniel M Dayeh, Bradley C Kruithoff, Kotaro Nakanishi
Some gene transcripts have cellular functions as regulatory noncoding RNAs. For example, ~23 nucleotide (nt)-long small interfering RNAs (siRNAs) are loaded into Argonaute proteins. The resultant ribonucleoprotein assembly, the RNA-induced silencing complex (RISC), cleaves RNAs that are extensively base-paired with the loaded siRNA. To date, base complementarity is recognized as the major determinant of specific target cleavage (or slicing), but little is known about how Argonaute inspects base pairing before cleavage...
March 8, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29517143/association-between-demographics-and-resilience-a-cross-sectional-study-among-nurses-in-singapore
#14
S Y Ang, T Uthaman, T C Ayre, S Z Mordiffi, E Ang, V Lopez
AIM: To give an overview of the level of resilience among nurses in Singapore and to examine associations between various demographics variables and resilience level. BACKGROUND: The World Health Organization reported a global needs-based shortage of over 9 million nurses and midwives in 2013. Building resilience among nurses has been postulated as one of the ways to support and retain nurses in the profession. METHOD: A self-reported questionnaire consisting of questions on demographics and the Connor-Davidson Resilience Scale CD-RISC 10 was used...
March 8, 2018: International Nursing Review
https://www.readbyqxmd.com/read/29507635/recent-advances-on-organic-blue-thermally-activated-delayed-fluorescence-tadf-emitters-for-organic-light-emitting-diodes-oleds
#15
REVIEW
Thanh-Tuân Bui, Fabrice Goubard, Malika Ibrahim-Ouali, Didier Gigmes, Frédéric Dumur
The design of highly emissive and stable blue emitters for organic light emitting diodes (OLEDs) is still a challenge, justifying the intense research activity of the scientific community in this field. Recently, a great deal of interest has been devoted to the elaboration of emitters exhibiting a thermally activated delayed fluorescence (TADF). By a specific molecular design consisting into a minimal overlap between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) due to a spatial separation of the electron-donating and the electron-releasing parts, luminescent materials exhibiting small S1 -T1 energy splitting could be obtained, enabling to thermally upconvert the electrons from the triplet to the singlet excited states by reverse intersystem crossing (RISC)...
2018: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29502765/resilience-linked-to-personality-dimensions-alexithymia-and-affective-symptoms-in-motor-functional-neurological-disorders
#16
Rozita Jalilianhasanpour, Benjamin Williams, Isabelle Gilman, Matthew J Burke, Sean Glass, Gregory L Fricchione, Matcheri S Keshavan, W Curt LaFrance, David L Perez
OBJECTIVE: Reduced resilience, a construct associated with maladaptive stress coping and a predisposing vulnerability for Functional Neurological Disorders (FND), has been under-studied compared to other neuropsychiatric factors in FND. This prospective case-control study investigated self-reported resilience in patients with FND compared to controls and examined relationships between resilience and affective symptoms, personality traits, alexithymia, health status and adverse life event burden...
April 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29499945/circ-shkbp1-regulates-the-angiogenesis-of-u87-glioma-exposed-endothelial-cells-through-mir-544a-foxp1-and-mir-379-foxp2-pathways
#17
Qianru He, Lini Zhao, Yunhui Liu, Xiaobai Liu, Jian Zheng, Hai Yu, Heng Cai, Jun Ma, Libo Liu, Ping Wang, Zhen Li, Yixue Xue
Circular RNAs (circRNAs) are a type of endogenous non-coding RNAs, which have been considered to mediate diverse tumorigenesis including angiogenesis. The present study aims to elucidate the potential role and molecular mechanism of circ-SHKBP1 in regulating the angiogenesis of U87 glioma-exposed endothelial cells (GECs). The expression of circ-SHKBP1, but not linear SHKBP1, was significantly upregulated in GECs compared with astrocyte-exposed endothelial cells (AECs). circ-SHKBP1 knockdown inhibited the viability, migration, and tube formation of GECs dramatically...
March 2, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/29499929/inhibition-of-tdp43-mediated-snhg12-mir-195-sox5-feedback-loop-impeded-malignant-biological-behaviors-of-glioma-cells
#18
Xiaobai Liu, Jian Zheng, Yixue Xue, Chengbin Qu, Jiajia Chen, Zhenhua Wang, Zhen Li, Lei Zhang, Yunhui Liu
Long non-coding RNA (lncRNA) dysregulation is involved in tumorigenesis and regulation of diverse cellular processes in gliomas. lncRNA SNHG12 is upregulated and promotes cell growth in human osteosarcoma cells. TAR-DNA binding protein 43 (TDP43) functions as an oncogene in various tumors by modulating RNA expression. Downregulation of TDP43 or SNHG12 significantly inhibited malignant biological behaviors of glioma cells. miR-195, downregulated in glioma tissues and cells, significantly impaired the malignant progression of glioma cells...
March 2, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/29488297/photomodulating-gene-expression-by-using-caged-sirnas-with-single-aptamer-modification
#19
Liangliang Zhang, Changmai Chen, Xinli Fan, Xinjing Tang
Caged siRNAs incorporating terminal modification were rationally designed for photochemical regulation of gene silencing induced by RNA interference (RNAi). Through the conjugation of a single oligonucleotide aptamer at the 5' terminus of the antisense RNA strand, enhancement of the blocking effect for RNA-induced silencing complex (RISC) formation/processing was expected, due both/either to the aptamers themselves and/or to their interaction with large binding proteins. Two oligonucleotide aptamers (AS1411 and MUC-1) were chosen for aptamer-siRNA conjugation through a photolabile linker...
February 28, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29476220/from-radiation-osteitis-to-osteoradionecrosis-incidence-and-mr-morphology-of-radiation-induced-sacral-pathologies-following-pelvic-radiotherapy
#20
Adrian J Meixel, Henrik Hauswald, Stefan Delorme, Björn Jobke
OBJECTIVE: To investigate the incidence rate, time-to-onset and recovery, MRI morphology and occurrence of insufficiency fractures in radiation-induced changes in the sacrum following pelvic radiotherapy. MATERIAL AND METHODS: 410 patients with pelvic malignancies treated with radiotherapy were reviewed. Follow-up was 1-124 months (mean 22 months). Serial MRI (average four studies/patient) were analysed using a new semi-quantitative score (Radiation-Induced Sacral Changes=RISC)...
February 23, 2018: European Radiology
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