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https://www.readbyqxmd.com/read/28317965/direct-observation-of-the-rise-of-delayed-fluorescence-in-dithienylbenzothiadiazole-and-its-role-in-the-excited-state-dynamics-of-a-donor-acceptor-donor-molecule
#1
Maneesha Esther Mohanty, Chakali Madhu, Vanammoole Lakshmi Reddy, Mahalingavelar Paramasivam, Prakriti Ranjan Bangal, Vaidya Jayathirtha Rao
Dithienylbenzothiadiazole (DTBT) is used as a building block in several molecules having application in organic light emitting devices (OLED) and organic photovoltaic (OPV) devices. Delayed fluorescence (DF) is the preferred design principle employed currently in OLED research. DTBT has excellent delayed fluorescence properties which makes this moiety a potentially viable OLED material. Here, the dynamics of intersystem crossing (ISC) and reverse intersystem crossing (RISC) have been explored using fluorescence, phosphorescence, fluorescence lifetime and transient absorption measurements...
March 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28304372/micrornas-mir-203-3p-mir-664-3p-and-mir-708-5p-are-associated-with-median-strain-lifespan-in-mice
#2
Benjamin P Lee, Ivana Burić, Anupriya George-Pandeth, Kevin Flurkey, David E Harrison, Rong Yuan, Luanne L Peters, George A Kuchel, David Melzer, Lorna W Harries
MicroRNAs (miRNAs) are small non-coding RNA species that have been shown to have roles in multiple processes that occur in higher eukaryotes. They act by binding to specific sequences in the 3' untranslated region of their target genes and causing the transcripts to be degraded by the RNA-induced silencing complex (RISC). MicroRNAs have previously been reported to demonstrate altered expression in several aging phenotypes such as cellular senescence and age itself. Here, we have measured the expression levels of 521 small regulatory microRNAs (miRNAs) in spleen tissue from young and old animals of 6 mouse strains with different median strain lifespans by quantitative real-time PCR...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28295056/guest-concentration-bias-current-and-temperature-dependent-sign-inversion-of-magneto-electroluminescence-in-thermally-activated-delayed-fluorescence-devices
#3
Junquan Deng, Weiyao Jia, Yingbing Chen, Dongyu Liu, Yeqian Hu, Zuhong Xiong
Non-emissive triplet excited states in devices that undergo thermally activated delayed fluorescence (TADF) can be up-converted to singlet excited states via reverse intersystem crossing (RISC), which leads to an enhanced electroluminescence efficiency. Exciton-based fluorescence devices always exhibit a positive magneto-electroluminescence (MEL) because intersystem crossing (ISC) can be suppressed effectively by an external magnetic field. Conversely, TADF devices should exhibit a negative MEL because RISC is suppressed by the external magnetic field...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28286891/nonadiabatic-coupling-reduces-the-activation-energy-in-thermally-activated-delayed-fluorescence
#4
J Gibson, T J Penfold
The temperature dependent rate of a thermally activated process is given by the Arrhenius equation. The exponential decrease in the rate with activation energy, which this imposes, strongly promotes processes with small activation barriers. This criterion is one of the most challenging during the design of thermally activated delayed fluorescence (TADF) emitters used in organic light emitting diodes. The small activation energy is usually achieved with donor-acceptor charge transfer complexes. However, this sacrifices the radiative rate and is therefore incommensurate with the high luminescence quantum yields required for applications...
March 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28285650/plasma-hdl-cholesterol-and-triglycerides-but-not-ldl-cholesterol-are-associated-with-insulin-secretion-in-non-diabetic-subjects
#5
Andrea Natali, Simona Baldi, Fabrice Bonnet, John Petrie, Silvia Trifirò, Domenico Tricò, Andrea Mari
OBJECTIVE: Experimental data support the notion that lipoproteins might directly affect beta cell function, however clinical data are sparse and inconsistent. We aimed at verifying whether, independently of major confounders, serum lipids are associated with alterations in insulin secretion or clearance non-diabetic subjects. METHODS: Cross sectional and observational prospective (3.5yrs), multicentre study in which 1016 non-diabetic volunteers aged 30-60yrs. and with a wide range of BMI (20...
April 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28279394/validation-and-application-of-the-chinese-version-of-the-10-item-connor-davidson-resilience-scale-cd-risc-10-among-parents-of-children-with-cancer-diagnosis
#6
Zeng Jie Ye, Hong Zhong Qiu, Peng Fei Li, Peng Chen, Mu Zi Liang, Mei Ling Liu, Yuan Liang Yu, Shu Ni Wang, Xiao Ming Quan
PURPOSE: Parents of children diagnosed with cancer often experience considerable emotional distress for their children with negative emotions, such as disbelief, depression, anxiety, hope and shock. Resilience is defined as the psychological characteristics that promote positive adaptation in the face of stress and adversity, which has been demonstrated to relate to positive coping and less psychological distress. Thus, a quick screening tool to evaluate the levels of resilience of parents with cancer-diagnosed children is urgently required...
April 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28275841/individual-level-factors-associated-with-mental-health-in-rwandan-youth-affected-by-hiv-aids
#7
Pamela Scorza, Cristiane S Duarte, Anne Stevenson, Christine Mushashi, Fredrick Kanyanganzi, Morris Munyana, Theresa S Betancourt
PURPOSE: Prevention of mental disorders worldwide requires a greater understanding of protective processes associated with lower levels of mental health problems in children who face pervasive life stressors. This study aimed to identify culturally appropriate indicators of individual-level protective factors in Rwandan adolescents where risk factors, namely poverty and a history of trauma, have dramatically shaped youth mental health. METHODS: The sample included 367 youth aged 10-17 in rural Rwanda...
March 8, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28273547/depression-and-resilience-mediates-the-effect-of-family-function-on-quality-of-life-of-the-elderly
#8
Canjie Lu, Lexin Yuan, Weiquan Lin, Ying Zhou, Shengmao Pan
BACKGROUND: Family function, which improves individual resilience and strongly link to quality of life (QOL) among the elderly, increases the risk of depression. Because of these demonstrated relationships, it can be hypothesized that both depression and resilience are mediators of the association between family function and QOL. METHODS: To test this hypothesis, the structural equation model (SEM) constructed by Amos 21.0 was employed to assess the indirect effect of depression (Geriatric Depression Scale, GDS) and resilience (Connor-Davidson Resilience Scale, CD-RISC) on the relationship between family function (Family APGAR Score, APGAR) and QOL (12-item Short Form health survey, SF-12) in 474 elderly adults from three communities in Guangzhou, China...
February 27, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28252184/using-morpholinos-to-control-gene-expression
#9
Jon D Moulton
Morpholino oligonucleotides are stable, uncharged, water-soluble molecules used to block complementary sequences of RNA, preventing processing, read-through, or protein binding at those sites. Morpholinos are typically used to block translation of mRNA and to block splicing of pre-mRNA, though they can block other interactions between biological macromolecules and RNA. Morpholinos are effective, specific, and lack non-antisense effects. They work in any cell that transcribes and translates RNA, but must be delivered into the nuclear/cytosolic compartment to be effective...
March 2, 2017: Current Protocols in Nucleic Acid Chemistry
https://www.readbyqxmd.com/read/28245169/long-non-coding-rna-linc0086-functions-as-a-tumor-suppressor-in-nasopharyngeal-carcinoma-by-targeting-mir-214
#10
Jie Guo, Jinqi Ma, Guosheng Zhao, Guocai Li, Yunfeng Fu, Yanwei Luo
Nasopharyngeal carcinoma (NPC) is a distinct head and neck cancer, occurring at high frequency in Southern China. Emerging studies have shown that long noncoding RNAs (lncRNAs) play critical roles in carcinogenesis and progression, including NPC. Here, we established a comprehensive lncRNA profiles in NPC and found that 35 lncRNAs were differentially expressed in NPC. We found that LINC0086 decreased in NPC patient serum samples and tissues. The Kaplan-Meier survival cure showed that the patients with high LINC0086 expression had higher survival rate than those with low LINC0086 expression...
February 13, 2017: Oncology Research
https://www.readbyqxmd.com/read/28244998/worth-the-risc
#11
Ken Garber
No abstract text is available yet for this article.
March 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28228216/non-canonical-targets-play-an-important-role-in-mirna-stability-control-mechanism
#12
June Hyun Park, Chanseok Shin
MicroRNAs (miRNAs) regulate gene expression by guiding Argonaute (Ago) containing RNA-induced silencing complex (RISC) to specific target mRNA molecules. It is well established that miRNAs are stabilized by Ago proteins, but the molecular features that triggers miRNA destabilization from Ago proteins remain largely unknown. To explore the molecular mechanisms of how targets affect the stability of miRNAs in human Ago (hAgo) proteins, we employed an in vitro system that consists of a minimal hAgo2-RISC in HEK293T cell lysates...
February 23, 2017: BMB Reports
https://www.readbyqxmd.com/read/28206832/veterinary-students-perspectives-on-resilience-and-resilience-building-strategies
#13
Jenny E Moffett, David J Bartram
In recent years, resilience has been lauded as a valuable, even necessary, facet of an effective veterinary practitioner. This study describes a mixed-methods research exploration of the impact of a self-care and mental well-being teaching intervention on the self-reported resilience of 105 first-year veterinary students enrolled at the School of Veterinary Medicine, University of Surrey, UK. Quantitative data were obtained through a questionnaire, the 10-item Connor-Davidson Resilience Scale (CD-RISC 10), which students completed before and after the teaching intervention...
2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28204845/mirnas-target-databases-developmental-methods-and-target-identification-techniques-with-functional-annotations
#14
REVIEW
Nagendra Kumar Singh
PURPOSE: microRNA (miRNA) regulates diverse biological mechanisms and metabolisms in plants and animals. Thus, the discoveries of miRNA has revolutionized the life sciences and medical research.The miRNA represses and cleaves the targeted mRNA by binding perfect or near perfect or imperfect complementary base pairs by RNA-induced silencing complex (RISC) formation during biogenesis process. One miRNA interacts with one or more mRNA genes and vice versa, hence takes part in causing various diseases...
February 15, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28199042/global-effects-of-income-and-income-inequality-on-adult-height-and-sexual-dimorphism-in-height
#15
Barry Bogin, Christiane Scheffler, Michael Hermanussen
OBJECTIVES: Average adult height of a population is considered a biomarker of the quality of the health environment and economic conditions. The causal relationships between height and income inequality are not well understood. We analyze data from 169 countries for national average heights of men and women and national-level economic factors to test two hypotheses: (1) income inequality has a greater association with average adult height than does absolute income; and (2) neither income nor income inequality has an effect on sexual dimorphism in height...
February 15, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28163933/analysis-of-argonaute-complex-bound-mrnas-in-du145-prostate-carcinoma-cells-reveals-new-mirna-target-genes
#16
Jaroslaw Szczyrba, Volker Jung, Michaela Beitzinger, Elke Nolte, Sven Wach, Martin Hart, Sandra Sapich, Marc Wiesehöfer, Helge Taubert, Gunther Wennemuth, Norbert Eichner, Thomas Stempfl, Bernd Wullich, Gunter Meister, Friedrich A Grässer
Posttranscriptional gene regulation by microRNAs (miRNAs) contributes to the induction and maintenance of prostate carcinoma (PCa). To identify mRNAs enriched or removed from Ago2-containing RISC complexes, these complexes were immunoprecipitated from normal prostate fibroblasts (PNFs) and the PCa line DU145 and the bound mRNAs were quantified by microarray. The analysis of Ago complexes derived from PNFs or DU145 confirmed the enrichment or depletion of a variety of mRNAs already known from the literature to be deregulated...
2017: Prostate Cancer
https://www.readbyqxmd.com/read/28152997/factor-structure-and-psychometric-evaluation-of-the-connor-davidson-resilience-scale-in-a-new-employee-population-of-china
#17
Lei Wu, Yan Tan, Yan Liu
BACKGROUND: In order to find a suitable instrument to evaluate psychological resilience in Chinese new employee population, we intended to propose a possible factorial structure of Connor-Davidson Resilience Scale (CD-RISC). Furthermore, we administered to explore its reliability and validity in the present population. METHODS: Participants were derived from the male new employees who had started working in the last 2-3 months from 12 machinery factories across 8 different provinces of China...
February 2, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28145904/overcoming-therapeutic-resistance-in-glioblastoma-the-way-forward
#18
REVIEW
Satoru Osuka, Erwin G Van Meir
Glioblastoma is the most common and lethal primary malignant brain tumor in adults. Patients die from recurrent tumors that have become resistant to therapy. New strategies are needed to design future therapies that target resistant cells. Recent genomic studies have unveiled the complexity of tumor heterogeneity in glioblastoma and provide new insights into the genomic landscape of tumor cells that survive and initiate tumor recurrence. Resistant cells also co-opt developmental pathways and display stem-like properties; hence we propose to name them recurrence-initiating stem-like cancer (RISC) cells...
February 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28143536/the-impact-of-resilience-on-psychological-outcomes-in-women-with-threatened-premature-labor-and-spouses-a-cross-sectional-study-in-southwest-china
#19
Chunhua Nie, Qin Dai, Ren Zhao, Yushu Dong, Yushan Chen, Hui Ren
BACKGROUND: Threatened premature labor (TPL) is a severe obstetric complication which affects the mental and physical health of both the mother and fetus. Family resilience may have protective role against psychological distress in women experiencing these pregnancy complications. There may be resilience related risk factors in TPL women, and interplays may exist among psychological variables and within couples. This study aims to examine psychological outcomes influenced by different levels of resilience, and explore psychological interactions in TPL women, spouses, and between women and spouses...
January 31, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28119422/non-canonical-targets-destabilize-micrornas-in-human-argonautes
#20
June Hyun Park, Sang-Yoon Shin, Chanseok Shin
Although much is known about microRNA (miRNA) biogenesis and the mechanism by which miRNAs regulate their targets, little is known about the regulation of miRNA stability. Mature miRNAs are stabilized by binding to Argonaute (Ago) proteins, the core components of the RNA-induced silencing complex (RISC). Recent studies suggest that interactions between miRNAs and their highly complementary target RNAs promote release of miRNAs from Ago proteins, and this in turn can lead to destabilization of miRNAs. However, the physiological triggers of miRNA destabilization with molecular mechanisms remain largely unknown...
January 24, 2017: Nucleic Acids Research
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