keyword
https://read.qxmd.com/read/38518638/emodin-8-o-%C3%AE-d-glucopyranoside-induced-hepatotoxicity-and-gender-differences-in-zebrafish-as-revealed-by-integration-of-metabolomics-and-transcriptomics
#21
JOURNAL ARTICLE
Ting Han, Wenjuan Xu, Xuan Wang, Jiahui Gao, Shuyan Zhang, Linlin Yang, Min Wang, Chunshuai Li, Xiangri Li
BACKGROUND: Emodin-8-O-β-D-glucopyranoside (Em8G) is an active ingredient of traditional Chinese medicine Rhei Radix et Rhizoma and Polygonum multiflorum Thunb.. And it caused hepatotoxicity, while the underlying mechanism was not clear yet. PURPOSE: We aimed to explore the detrimental effects of Em8G on the zebrafish liver through the metabolome and transcriptome integrated analysis. STUDY DESIGN AND METHODS: In this study, zebrafish larvae were used in acute toxicity tests to reveal the hepatotoxicity of Em8G...
February 8, 2024: Phytomedicine
https://read.qxmd.com/read/38516747/protective-effect-of-black-seed-and-lettuce-oils-against-paracetamol-induced-hepatotoxicity-in-rats
#22
JOURNAL ARTICLE
Elsayed Hamed Ali Bakr, Areej Abdulhamid Hamdan Almuraee
<b>Background and Objective:</b> The liver is one of the organs that play an essential role in the human body, including supporting metabolism, immune functions, digestive system, detoxification, storage of vitamins and other functions. This investigation aimed to study the protective effects of black seed and lettuce oil against hepatotoxicity as induced by paracetamol in experimental rats. <b>Materials and Methods:</b> Twenty male Sprague-Dawley albino rats weighing 150±5 g were divided randomly into four groups (5 rats each) and distributed as follows; 1st group was controlled negative (C -ve group), 2nd group controlled positive (orally administered with 500 mg/kg b...
January 2024: Pakistan Journal of Biological Sciences: PJBS
https://read.qxmd.com/read/38513874/predictive-factors-for-dose-reduction-and-discontinuation-of-nintedanib-in-fibrotic-interstitial-lung-diseases-real-life-data
#23
JOURNAL ARTICLE
Emanuel Costa, Ana Rita Pedroso, Rita Matos, Márcio Cunha Rodrigues, Eva Padrão, Joana Sousa-Neves, Rui Rolo
Nintedanib, an intracellular inhibitor targeting multiple tyrosine kinases, has emerged as a standard treatment for various fibrotic lung diseases. Despite its efficacy, side effects such as nausea, diarrhea, and hepatotoxicity often lead to dose reduction or discontinuation. In this retrospective analysis at a university hospital's interstitial lung disease clinic, we aimed to identify baseline characteristics associated with dose adjustment or treatment discontinuation. Of the 58 patients included, 41.4% maintained the full nintedanib dose, while 31...
March 19, 2024: Respiratory Medicine
https://read.qxmd.com/read/38513556/evidence-of-promoting-effects-of-6-2-cl-pfesa-on-hepatocellular-carcinoma-proliferation-in-humans-an-ideal-alternative-for-pfos-in-terms-of-environmental-health
#24
JOURNAL ARTICLE
Jiawei Hong, Keyi Du, Hangbiao Jin, Yuanchen Chen, Yifan Jiang, Weichen Zhang, Diyu Chen, Shusen Zheng, Linping Cao
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are synthetic chemicals, encompassing compounds like perfluorooctane sulfonate (PFOS), which have widespread applications across various industries, including food packaging and firefighting. In recent years, China has increasingly employed 6:2 Cl-PFESA as an alternative to PFOS. Although the association between PFAS exposure and hepatocellular carcinoma (HCC) has been demonstrated, the underlying mechanisms that promote HCC proliferation are uncleared. Therefore, we aimed to investigate the effects and differences of PFOS and 6:2 Cl-PFESA on HCC proliferation through in vivo and in vitro tumor models...
March 16, 2024: Environment International
https://read.qxmd.com/read/38512019/sex-differences-in-the-susceptibility-to-valproic-acid-associated-liver-injury-in-epileptic-patients
#25
JOURNAL ARTICLE
Linfeng Ma, Dan Wang
BACKGROUND: Valproic acid has been widely used as an antiepileptic drug for several decades. Long-term valproic acid treatment is usually accompanied by liver injury. Although both men and women are susceptible to valproic acid-associated liver injury, hepatotoxicity differs between the sexes. However, the mechanisms underlying sex differences in valproic acid-associated liver injury remain unclear. METHODS: To explore potential risk factors for the susceptibility to valproic acid-associated liver injury, 231 pediatric patients with epilepsy (119 males, 112 females) were enrolled for laboratory and genetic analysis...
February 2024: Clinical Toxicology
https://read.qxmd.com/read/38510874/drug-induced-liver-injury-secondary-to-terbinafine-use
#26
Aaron Brown, Mark Potesta, Ajmal Hameed
Drug-induced liver injury (DILI) has a symptomatic profile that mimics many forms of hepatic injury. In patients presenting with symptoms suspicious of acute liver injury, it is important that clinicians effectively rule out more common causes while simultaneously maintaining a broad differential diagnosis that includes DILI. In this report, we present the case of a 41-year-old African American male who was admitted to the hospital for two weeks' duration of worsening jaundice, right upper quadrant pain, pruritus, and acholic stools after terbinafine use for an acute episode of onychomycosis...
February 2024: Curēus
https://read.qxmd.com/read/38509509/grade-adolopment-of-hyperthyroidism-treatment-guidelines-for-a-pakistani-context
#27
JOURNAL ARTICLE
Russell Seth Martins, Sarah Nadeem, Abeer Aziz, Sajjan Raja, Alina Pervez, Najmul Islam, Asma Ahmed, Aisha Sheikh, Saira Furqan, Nanik Ram, Azra Rizwan, Nashia Ali Rizvi, Mohsin Ali Mustafa, Salima Saleem Aamdani, Bushra Ayub, Muhammad Qamar Masood
INTRODUCTION: The prevalence of hyperthyroidism in Pakistan is 2.9%, which is two times higher than in the United States. Most high-quality hyperthyroidism clinical practice guidelines (CPGs) used internationally originate from high-income countries in the West. Local CPGs in Pakistan are not backed by transparent methodologies. We aimed to produce comprehensive, high-quality CPGs for the management of hyperthyroidism in Pakistan. METHODS: We employed the GRADE-ADOLOPMENT approach utilizing the 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis as the source CPG...
March 21, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38508538/evaluation-of-effectiveness-hyperkalemia-and-hepatotoxicity-of-trimethoprim-sulfamethoxazole-prophylaxis-for-pneumocystis-jirovecii-pneumonia-in-pediatric-patients-a-single-center-retrospective-study
#28
JOURNAL ARTICLE
Hideo Kato, Mao Hagihara, Nobuhiro Asai, Hiroshige Mikamo, Takuya Iwamoto
BACKGROUND: American guidelines recommend trimethoprim-sulfamethoxazole (TMP-SMX) for preventing Pneumocystis jirovecii pneumonia (PJP) in pediatric patients at doses of 5-10 mg/kg/day of the TMP component, administered either daily, three times weekly, or twice weekly. However, limited studies describe the effectiveness and safety of these prophylactic regimens. Our study aimed to assess the clinical effectiveness and incidence of adverse events associated with each TMP-SMX regimen in pediatric patients, and to identify risk factors for adverse events...
March 18, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38507877/hepatotoxicity-in-patients-with-non-small-cell-lung-cancer-treated-with-sotorasib-after-prior-immunotherapy-a-comprehensive-clinical-and-pharmacokinetic-analysis
#29
JOURNAL ARTICLE
Sophie M Ernst, Maaike M Hofman, Tessa E van der Horst, Marthe S Paats, Frank W J Heijboer, Joachim G J V Aerts, Daphne W Dumoulin, Robin Cornelissen, Jan H von der Thüsen, Peter de Bruijn, Esther Oomen-de Hoop, Ron H J Mathijssen, Stijn L W Koolen, Anne-Marie C Dingemans
BACKGROUND: Sotorasib given after immunotherapy could put patients at increased risk of hepatotoxicity. Therefore, there is a need to gain insight into the potential correlation between anti-PD-(L)1 treatment, anti-PD-(L)1 concentrations, sotorasib concentrations, and the incidence of hepatotoxicity during sotorasib. METHODS: Patients with KRASG12C -mutated NSCLC treated with sotorasib were prospectively enrolled in our biomarker cohort study (NCT05221372). Plasma samples were collected prior and during sotorasib treatment for anti-PD-1 and sotorasib concentrations...
March 19, 2024: EBioMedicine
https://read.qxmd.com/read/38505599/a-case-of-hepatotoxicity-induced-by-therapeutic-ketamine-use-for-sedation
#30
Noah Yoo, Sarun Thomas, Michael Bender, Xian Jie Cindy Cheng
Ketamine, initially developed as an anesthetic, has shown versatility in medical applications, including pain management, treatment-resistant depression, and sedation in the intensive care unit (ICU). While generally well-tolerated, long-term use at high doses raises concerns about potential toxicities, particularly in the liver. We present a case of a 27-year-old female with a complex medical history who received ketamine infusion for ICU sedation and experienced a sudden rise in liver function tests (LFTs), indicating possible ketamine-induced liver injury (KILI)...
2024: Case Reports in Critical Care
https://read.qxmd.com/read/38504503/drug-reactive-metabolite-induced-hepatotoxicity-a-comprehensive-review
#31
REVIEW
Piyush Mahajan, Mahesh Palkar, Ravindra Babu Pingili
Nowadays, drug-induced liver toxicity (DILT) is one of the main contributing factors to severe liver disease. In the United States (US) alone, DILT is the cause of more than 50% of instances of acute liver failure. Prescription or over-the-counter drugs, xenobiotics, and herbal and nutritional supplements can cause DILT and could produce anomalies in hepatic function tests. Some drugs induce hepatotoxicity directly, and others induce it indirectly (i. e. through their toxic or reactive metabolites). Currently, the United States Food and Drug Administration (US FDA) has issued black box warnings to about 1279 drugs due to their hepatotoxicity...
March 19, 2024: Toxicology Mechanisms and Methods
https://read.qxmd.com/read/38504260/inverse-association-between-plasma-chlordecone-concentrations-and-progression-of-alcoholic-liver-fibrosis-the-role-of-liver-metabolism
#32
JOURNAL ARTICLE
Moana Gelu-Simeon, Marie-Josée Lafrance, Leah Michineau, Eric Saillard, Jean Pierre Thomé, Claude Emond, Michel Samson, Luc Multigner
BACKGROUND AND AIMS: Chlordecone is a persistent organochlorinated insecticide, extensively used in the French West Indies and has been contaminating the population for more than thirty years. Its potentiation effect on hepatotoxic agents has been demonstrated in animal models. We investigated the relationship between environmental exposure to chlordecone and the progression of liver fibrosis. METHODS: This study included 182 consecutive patients with chronic alcoholic hepatitis whose liver fibrosis was assessed using non-invasive methods...
March 20, 2024: Environmental Health
https://read.qxmd.com/read/38502791/multifaceted-effects-of-subchronic-exposure-to-chlorfenapyr-in-mice-implications-from-serum-metabolomics-hepatic-oxidative-stress-and-intestinal-homeostasis
#33
JOURNAL ARTICLE
Yabing Xiong, Xiaoran Ma, Bingying He, Jianwen Zhi, Xueke Liu, Peng Wang, Zhiqiang Zhou, Donghui Liu
As chlorfenapyr is a commonly used insecticide in agriculture, the health risks of subchronic exposure to chlorfenapyr remained unclear. This study aimed to extensively probe the health risks from subchronic exposure to chlorfenapyr at the NOAEL and 10-fold NOAEL dose in mice. Through pathological and biochemical examinations, the body metabolism, hepatic toxicity, and intestinal homeostasis were systematically assessed. After 12 weeks, a 10-fold NOAEL dose of chlorfenapyr resulted in weight reduction, increased daily food intake, and blood lipid abnormalities...
March 19, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38501993/hepatitis-a-virus-infection-in-cynomolgus-monkeys-confounds-the-safety-evaluation-of-a-drug-candidate
#34
JOURNAL ARTICLE
Chris J Powell, John C Kapeghian, John C Bernal, John R Foster
In a 3-month toxicity study in cynomolgus monkeys at a European contract laboratory, animals were infected with HAV, initially resulting in hepatic injury being incorrectly attributed to the test compound. Elevated serum ALT/AST/GLDH (5- to 10-fold) were noted in individual animals from all groups including controls, with no apparent dose, exposure, or time-related relationship. Liver histopathology revealed minimal to slight inflammatory cell accumulation in periportal zones of most animals, and minimal to slight hepatocyte degeneration/necrosis in 10/42 animals from all groups...
March 19, 2024: International Journal of Toxicology
https://read.qxmd.com/read/38501978/atg-101-is-a-tetravalent-pd-l1%C3%A3-4-1bb-bispecific-antibody-that-stimulates-anti-tumor-immunity-through-pd-l1-blockade-and-pd-l1-directed-4-1bb-activation
#35
JOURNAL ARTICLE
Hui Yuwen, Huajing Wang, Tengteng Li, Yijing Ren, Yun-Kai Zhang, Peng Chen, Ao Sun, Gang Bian, Bohua Li, David Flowers, Marc Presler, Kalyanasundaram Subramanian, Jia Xue, Jingjing Wang, Kevin Lynch, Jay Mei, Xiaowen He, Bo Shan, Bing Hou
Immune checkpoint inhibitors (ICI) have transformed cancer treatment. However, only a minority of patients achieve a profound response. Many patients are innately resistant while others acquire resistance to ICIs. Furthermore, hepatotoxicity and suboptimal efficacy have hampered the clinical development of agonists of 4-1BB, a promising immune stimulating target. To effectively target 4-1BB and treat diseases resistant to ICIs, we engineered ATG-101, a tetravalent "2+2" PD-L1×4-1BB bispecific antibody...
March 19, 2024: Cancer Research
https://read.qxmd.com/read/38501915/boron-facilitates-amelioration-of-hepatic-injury-by-the-osmolyte-glycine-and-resolves-injury-by-improving-the-tissue-redox-homeostasis
#36
JOURNAL ARTICLE
Humaira Farooqui, Farah Anjum, Djamel Lebeche, Shakir Ali
Background: Glycine is a conditional non-essential amino acid in human and other mammals. It is abundant in the liver and is known for a wide spectrum of characteristics including the antioxidant, antiinflammatory, immunomodulatory, and cryoprotective effects. The amino acid is a naturally occurring osmolyte compatible with protein surface interactions and has been reported in literature as a potent therapeutic immuno-nutrient for liver diseases such as alcoholic liver disease. Oral glycine administration protects ethanol-induced liver injury, improves serum and tissue lipid profile, and alleviates hepatic injury in various conditions...
March 19, 2024: Journal of Dietary Supplements
https://read.qxmd.com/read/38501267/risk-factors-associated-with-high-dose-methotrexate-induced-toxicities
#37
REVIEW
Wenshu Li, Jiayi Mo, Zhilin Yang, Zhigang Zhao, Shenghui Mei
INTRODUCTION: High-dose methotrexate (HDMTX) therapy poses challenges in various neoplasms due to individualized pharmacokinetics and associated adverse effects. Our purpose is to identify early risk factors associated with HDMTX-induced toxicities, paving the way for personalized treatment. AREAS COVERED: A systematic review of PubMed and Cochrane databases was conducted for articles from inception to July 2023. Eligible studies included reviews, clinical trials, and real-world analyses...
March 19, 2024: Expert Opinion on Drug Metabolism & Toxicology
https://read.qxmd.com/read/38500515/grape-seed-proanthocyanins-protect-fluoride-induced-hepatotoxicity-via-the-nrf2-signaling-pathway-in-male-rats
#38
JOURNAL ARTICLE
Ran Wei, Guan Fang Ping, Zhe Tao Lang, Er Hui Wang
BACKGROUND: Fluoride is a necessary element for human health, but excessive fluoride intake is found toxic to the liver. Previous studies confirmed that Grape seed procyanidin extract (GSPE) protects against fluoride-induced hepatic injury. However, the mechanism underlying this protective effect remains obscure. To evaluate the protective effect of GSPE against fluoride-induced hepatic injury and explore the possible hepatoprotective role of the Nrf2 signaling pathway to find effective strategies for the treatment and prevention of fluoride-induced hepatotoxicity...
April 2024: Toxicology Research
https://read.qxmd.com/read/38500399/boldine-protects-against-carbon-tetrachloride-induced-chronic-liver-injury-by-regulating-nf-%C3%AE%C2%BAb-signaling-pathway
#39
JOURNAL ARTICLE
Devaraj Ezhilarasan, Karthik Shree Harini, Munusamy Karthick, Prathap Lavanya
Sustained liver injuries predominantly promote oxidative stress and inflammation that lead to the progression of chronic liver disease (CLD), including fibrosis, cirrhosis, and hepatocellular carcinoma. Boldine, an alkaloid isolated from Peumus boldus, has been shown to have antioxidant and anti-inflammatory effects. Currently, there is no definitive treatment option available for CLD. Therefore, we investigated the hepatoprotective effect of boldine against carbon tetrachloride (CCl4 )-induced chronic liver injury in rats...
April 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38499285/trifluoperazine-mitigates-cyclophosphamide-induced-hepatic-oxidative-stress-inflammation-and-apoptosis-in-mice-by-modulating-the-akt-mtor-driven-autophagy-and-nrf2-ho-1-signaling-cascades
#40
JOURNAL ARTICLE
Ahmed K Saleh, Nageh A El-Mahdy, Thanaa A El-Masry, Aya H El-Kadem
AIM: This study aims to investigate the hepatoprotective effect of the antipsychotic drug trifluoperazine (TFP) against cyclophosphamide (CPA)-induced hepatic injury by exploring its effect on autophagy and the Nrf2/HO-1 signaling pathway. MAIN METHODS: The hepatotoxicity of CPA was assessed by biochemical analysis of the serum hepatotoxicity markers (ALT, AST, and direct bilirubin), histopathological examination, and ultrastructure analysis by transmission electron microscopy (TEM)...
March 16, 2024: Life Sciences
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