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https://www.readbyqxmd.com/read/28315422/sfpq-psf-tfe3-renal-cell-carcinoma-rcc-a-clinicopathologic-study-emphasizing-extended-morphology-and-reviewing-the-differences-between-sfpq-tfe3-rcc-and-the-corresponding-mesenchymal-neoplasm-despite-an-identical-gene-fusion
#1
Xiao-Tong Wang, Qiu-Yuan Xia, Hao Ni, Sheng-Bing Ye, Rui Li, Xuan Wang, Shan-Shan Shi, Xiao-Jun Zhou, Qiu Rao
Xp11 translocation renal cell carcinoma (RCC) with SFPQ/PSF-TFE3 gene fusion is a rare epithelial tumor. Of note, the appearance of the gene fusion does not necessarily mean that it is renal cell carcinoma. The corresponding mesenchymal neoplasms, including Xp11 neoplasm with melanocytic differentiation, TFE3 rearrangement-associated perivascular epithelioid cell tumor (PEComa) and melanotic Xp11 translocation renal cancer, can also harbor the identical gene fusion. However, the differences between Xp11 translocation RCC and the corresponding mesenchymal neoplasm have only recently been described...
March 14, 2017: Human Pathology
https://www.readbyqxmd.com/read/28303790/design-of-robust-adaptive-controller-and-feedback-error-learning-for-rehabilitation-in-parkinson-s-disease-a-simulation-study
#2
Korosh Rouhollahi, Mehran Emadi Andani, Seyed Mahdi Karbassi, Iman Izadi
Deep brain stimulation (DBS) is an efficient therapy to control movement disorders of Parkinson's tremor. Stimulation of one area of basal ganglia (BG) by DBS with no feedback is the prevalent opinion. Reduction of additional stimulatory signal delivered to the brain is the advantage of using feedback. This results in reduction of side effects caused by the excessive stimulation intensity. In fact, the stimulatory intensity of controllers is decreased proportional to reduction of hand tremor. The objective of this study is to design a new controller structure to decrease three indicators: (i) the hand tremor; (ii) the level of delivered stimulation in disease condition; and (iii) the ratio of the level of delivered stimulation in health condition to disease condition...
February 2017: IET Systems Biology
https://www.readbyqxmd.com/read/28302761/performance-characteristics-of-the-whole-body-discovery-iq-pet-ct-system
#3
Gabriel Reynes-Llompart, Cristina Gámez-Cenzano, Inma Romero-Zayas, Laura Rodriguez-Bel, José Luís Vercher-Conejero, Josep M Martí-Climent
Purpose: The aim of this study was to assess the physical performance of a new PET/CT system Discovery IQ 5 Rings (General Electric, Milwaukee, WI). Methods: Performance measurements were obtained using the NEMA NU2-2012 methodology. Image quality was extended by accounting for different acquisition parameters (lesion-to-background ratios of 8:1, 4:1 and 2:1 and acquisition times) as well as different reconstruction algorithms (VPHD, VPHD-S and Q.Clear). Tomographic reconstruction was also assessed using a Jaszczak phantom...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28300387/real-time-ray-casting-based-scatter-dose-estimation-for-c-arm-x-ray-system
#4
Zaid Alnewaini, Eric Langer, Philipp Schaber, Matthias David, Dominik Kretz, Volker Steil, Jürgen Hesser
OBJECTIVES: Dosimetric control of staff exposure during interventional procedures under fluoroscopy is of high relevance. In this paper, a novel ray casting approximation of radiation transport is presented and the potential and limitation vs. a full Monte Carlo transport and dose measurements are discussed. METHOD: The x-ray source of a Siemens Axiom Artix C-arm is modeled by a virtual source model using single Gaussian-shaped source. A Geant4-based Monte Carlo simulation determines the radiation transport from the source to compute scatter from the patient, the table, the ceiling and the floor...
March 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28295087/high-numerical-aperture-na%C3%A2-%C3%A2-0-92-objective-lens-for-imaging-and-addressing-of-cold-atoms
#5
Carsten Robens, Stefan Brakhane, Wolfgang Alt, Felix Kleißler, Dieter Meschede, Geol Moon, Gautam Ramola, Andrea Alberti
We have designed, built, and characterized a high-resolution objective lens that is compatible with an ultrahigh vacuum environment. The lens system exploits the principle of the Weierstrass sphere solid immersion lens to reach a numerical aperture (NA) of 0.92. Tailored to the requirements of optical lattice experiments, the objective lens features a relatively long working distance of 150 μm. Our two-lens design is remarkably insensitive to mechanical tolerances in spite of the large NA. Additionally, we demonstrate the application of a tapered optical fiber tip, as used in scanning near-field optical microscopy, to measure the point spread function (PSF) of a high NA optical system...
March 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28294996/design-and-imaging-of-ground-based-multiple-input-multiple-output-synthetic-aperture-radar-mimo-sar-with-non-collinear-arrays
#6
Cheng Hu, Jingyang Wang, Weiming Tian, Tao Zeng, Rui Wang
Multiple-Input Multiple-Output (MIMO) radar provides much more flexibility than the traditional radar thanks to its ability to realize far more observation channels than the actual number of transmit and receive (T/R) elements. In designing the MIMO imaging radar arrays, the commonly used virtual array theory generally assumes that all elements are on the same line. However, due to the physical size of the antennas and coupling effect between T/R elements, a certain height difference between T/R arrays is essential, which will result in the defocusing of edge points of the scene...
March 15, 2017: Sensors
https://www.readbyqxmd.com/read/28288210/depletion-of-neat1-lncrna-attenuates-nucleolar-stress-by-releasing-sequestered-p54nrb-and-psf-to-facilitate-c-myc-translation
#7
Wen Shen, Xue-Hai Liang, Hong Sun, Cheryl L De Hoyos, Stanley T Crooke
Altered expression of NEAT1, the architectural long non-coding RNA (lncRNA) of nuclear paraspeckles, has been reported during tumorigenesis, as well as under various cellular stress conditions. Here we report that the depletion of NEAT1 lncRNA alleviates nucleolar stress during RNAP I inhibition through releasing sequestered P54nrb and PSF to facilitate the IRES-dependent translation of c-Myc. RNAP I inhibitor CX5461 disrupts the SL1-rDNA interaction and induces nucleolar disruption, demonstrated by the accumulation of fibrillarin-containing nucleoplasmic foci and nucleolar clearance of ribosomal proteins in HeLa cells...
2017: PloS One
https://www.readbyqxmd.com/read/28285104/eco-friendly-membrane-process-and-product-development-for-complete-elimination-of-chromium-toxicity-in-wastewater
#8
Jyothi M S, Vignesh Nayak, Mahesh Padaki, R Geetha Balakrishna, Khantong Soontarapa
Hydrophobic polysulphone (PSf) was reformed into a hydrophilic polymer by sulphonation (via electrophilic substitution) and was subsequently made into a composite by incorporating nano titania to reduce Cr (VI) in the concentrated feed to Cr (III), thus eliminating the hazards of Cr (VI). The modified polymer and its composites were characterized by spectroscopic and microscopic techniques. The composite membranes exhibited enhanced hydrophilicity and flux and were evaluated for the rejection of chromium. The effect of pH and interference of counter ions towards rejection was studied...
March 6, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28283853/long-t2-suppression-in-native-lung-3-d-imaging-using-k-space-reordered-inversion-recovery-dual-echo-ultrashort-echo-time-mri
#9
Neville D Gai, Ashkan A Malayeri, David A Bluemke
OBJECTIVE: Long T2 species can interfere with visualization of short T2 tissue imaging. For example, visualization of lung parenchyma can be hindered by breathing artifacts primarily from fat in the chest wall. The purpose of this work was to design and evaluate a scheme for long T2 species suppression in lung parenchyma imaging using 3-D inversion recovery double-echo ultrashort echo time imaging with a k-space reordering scheme for artifact suppression. MATERIALS AND METHODS: A hyperbolic secant (HS) pulse was evaluated for different tissues (T1/T2)...
March 10, 2017: Magma
https://www.readbyqxmd.com/read/28279871/filtration-and-removal-performances-of-membrane-adsorbers
#10
Yilmaz Yurekli, Mehmet Yildirim, Levent Aydin, Melih Savran
Membrane adsorbers are promising candidates for the efficient and effective removal of heavy metals in waste water due to their unattainable adsorption and filtration capabilities. In the present study, zeolite nanoparticles incorporated polysulfone (PSf10) membrane was synthesized by means of non-solvent induced phase separation technique for the removal of lead and nickel ions in water. PSf10 showed a remarkable sorption capability and after repeated (adsorption/desorption)5 cycles in batch experiments, it preserved 77% and 92% of its initial sorption capacity for the lead and nickel, respectively...
March 1, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28279766/structural-characterization-of-immunostimulating-protein-sulfated-fucan-complex-extracted-from-the-body-wall-of-a-sea-cucumber-stichopus-japonicus
#11
Rong-An Cao, Utoomporn Surayot, SangGuan You
The water soluble protein-sulfated fucan (PSF) complex isolated from the body wall of Stichopus japonicus was fractionated using an anion-exchange chromatography to obtain four purified fractions (F1, F2, F3, and F4) and to investigate their structural characteristics and immuno-enhancing activities. The crude PSF and fractions mostly consisted of neutral sugars, proteins and sulfates in various proportions. Fucose was their major monosaccharide unit with small portion of mannose, glucose and galactose. The molecular weight (Mw) of the crude PSF and fractions ranged from 323...
March 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28275975/design-and-performance-evaluation-of-a-new-high-energy-parallel-hole-collimator-for-radioiodine-planar-imaging-by-gamma-cameras-monte-carlo-simulation-study
#12
Vahid Moslemi, Mansour Ashoor
OBJECTIVE: In addition to the trade-off between resolution and sensitivity which is a common problem among all types of parallel hole collimators (PCs), obtained images by high energy PCs (HEPCs) suffer from hole-pattern artifact (HPA) due to further septa thickness. In this study, a new design on the collimator has been proposed to improve the trade-off between resolution and sensitivity and to eliminate the HPA. METHODS: A novel PC, namely high energy extended PC (HEEPC), is proposed and is compared to HEPCs...
March 8, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28273579/novel-modified-poly-vinyl-chloride-blend-membranes-for-removal-of-heavy-metals-from-mixed-ion-feed-sample
#13
Vignesh Nayak, M S Jyothi, R Geetha Balakrishna, Mahesh Padaki, Sebastien Deon
Herein, an attempt has been made to prepare a novel membrane with good efficiency for removal of heavy metal ions namely lead (Pb), cadmium (Cd) and chromium (Cr). 4-amino benzoic acid (ABA) was covalently grafted onto the poly vinyl chloride (PVC) backbone by CN bond to enhance the hydrophilicity. (1)H NMR and ATR-IR spectroscopy analysis confirmed the chemical modification of PVC. Further the modified polymer was blended in different compositions with polysulfone (PSf) for optimization. Morphological changes that occurred in blend membranes, due to the incorporation of modified PVC was studied by AFM and SEM techniques...
February 27, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28273347/a-phantom-study-should-124-i-mibg-pet-ct-replace-123-i-mibg-spect-ct
#14
Casper Beijst, Bart de Keizer, Marnix G E H Lam, Geert O Janssens, Godelieve A M Tytgat, Hugo W A M de Jong
PURPOSE: The isotope (123) I is commonly labeled with meta-iodobenzylguanidine (mIBG) for imaging of neuroendocrine tumors, such as pheochromocytomas and neuroblastomas. (123) I-mIBG SPECT/CT imaging is performed for staging, follow-up and selection of patients for treatment with (131) I mIBG. As an alternative to (123) I, (124) I-mIBG PET/CT may be used, potentially taking advantage of the superior PET image quality. The purpose of this study was to investigate whether (124) I PET/CT improves image quality as compared with (123) I SPECT/CT for equal patient effective radiation dose (in mSv)...
March 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28272296/performance-of-carbon-nanotube-polysulfone-cnt-psf-composite-membranes-during-oil-water-mixture-separation-effect-of-cnt-dispersion-method
#15
Michael Olawale Daramola, Palesa Hlanyane, Oluwafolakemi O Sadare, Olugbenga O Oluwasina, Sunny E Iyuke
Effect of the dispersion method employed during the synthesis of carbon nanotube (CNT)/polysulfone-infused composite membranes on the quality and separation performance of the membranes during oil-water mixture separation is demonstrated. Carbon nanotube/polysulfone composite membranes containing 5% CNT and pure polysulfone membrane (with 0% CNT) were synthesized using phase inversion. Three CNT dispersion methods referred to as Method 1 (M1), Method 2 (M2), and Method 3 (M3) were used to disperse the CNTs...
March 6, 2017: Membranes
https://www.readbyqxmd.com/read/28268994/ultrasound-plane-wave-imaging-with-delay-multiply-and-sum-beamforming-and-coherent-compounding
#16
Giulia Matrone, Alessandro S Savoia, Giosue Caliano, Giovanni Magenes
Improving the frame rate is an important aspect in medical ultrasound imaging, particularly in 3D/4D cardiac applications. However, an accurate trade-off between the higher frame rate and image contrast and resolution should be performed. Plane-Wave Imaging (PWI) can potentially achieve frame rates in the order of 10 kHz, as it uses a single unfocused plane wave (and thus a single transmit event) to acquire the image of the entire region of interest. The lack of transmit focusing however causes a significant drop of image quality, which can be restored by coherently compounding several tilted plane-wave frames, at the expense of the frame rate...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268367/bayesian-deconvolution-of-scanning-electron-microscopy-images-using-point-spread-function-estimation-and-non-local-regularization
#17
Joris Roels, Jan Aelterman, Jonas De Vylder, Hiep Luong, Yvan Saeys, Wilfried Philips
Microscopy is one of the most essential imaging techniques in life sciences. High-quality images are required in order to solve (potentially life-saving) biomedical research problems. Many microscopy techniques do not achieve sufficient resolution for these purposes, being limited by physical diffraction and hardware deficiencies. Electron microscopy addresses optical diffraction by measuring emitted or transmitted electrons instead of photons, yielding nanometer resolution. Despite pushing back the diffraction limit, blur should still be taken into account because of practical hardware imperfections and remaining electron diffraction...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263228/pain-is-the-greatest-preoperative-concern-for-patients-and-parents-prior-to-posterior-spinal-fusion-for-adolescent-idiopathic-scoliosis
#18
Priscella Chan, David Skaggs, Austin Sanders, Gabriela A Villamor, Paul D Choi, Vernon Tolo, Lindsay M Andras
STUDY DESIGN: Prospective cross-sectional study OBJECTIVE.: To evaluate patients' and parents' concerns so they can be addressed with appropriate preoperative counseling. SUMMARY OF BACKGROUND DATA: Despite much research on outcomes for posterior spinal fusion (PSF) in adolescent idiopathic scoliosis (AIS), little is available about preoperative fears or concerns. METHODS: AIS patients undergoing PSF, their parents, and surgeons, were prospectively enrolled and asked to complete a survey on their fears and concerns about surgery at their preoperative appointment...
March 3, 2017: Spine
https://www.readbyqxmd.com/read/28254456/linking-brain-vascular-physiology-to-hemodynamic-response-in-ultra-high-field-mri
#19
Kâmil Uludağ, Pablo Blinder
Functional MRI using blood oxygenation level-dependent (BOLD) contrast indirectly probes neuronal activity via evoked cerebral blood volume (CBV) and oxygenation changes. Thus, its spatio-temporal characteristics are determined by vascular physiology and MRI parameters. In this paper, we focus on the spatial distribution and time course of the fMRI signal and their magnetic field strength dependence. Even though much is still unknown, the following consistent picture is emerging: a) For high spatial resolution imaging, fMRI contrast-to-noise increases supra-linearly with field strength...
February 22, 2017: NeuroImage
https://www.readbyqxmd.com/read/28254281/polysulfone-hemodiafiltration-membranes-with-enhanced-anti-fouling-and-hemocompatibility-modified-by-poly-vinyl-pyrrolidone-via-in-situ-cross-linked-polymerization
#20
Lijing Zhu, Haiming Song, Jiarong Wang, Lixin Xue
Poly(vinyl pyrrolidone) (PVP) and its copolymers have been widely employed for the modification of hemodiafiltration membranes due to their excellent hydrophilicity, antifouling and hemocompatibility. However, challenges still remain to simplify the modification procedure and to improve the utilization efficiency. In this paper, antifouling and hemocompatibility polysulfone (PSf) hemodiafiltration membranes were fabricated via in situ cross-linked polymerization of vinyl pyrrolidone (VP) and vinyltriethoxysilane (VTEOS) in PSf solutions and non-solvent induced phase separation (NIPS) technique...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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