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https://www.readbyqxmd.com/read/28944950/comparison-of-unilateral-versus-bilateral-pedicle-screw-fixation-in-transforaminal-lumbar-interbody-fusion-for-single-level-lumbar-degenerative-diseases-and-review-of-literature
#1
Hasan Serdar Işik, Özerk Okutan, Timur Yildirim, Elif Akpinar, Ali Yilmaz
AIM: There are some recognized treatment modalities in the literature for the treatment of lumbar degenerative diseases,which cause pain and avoidance of daily life activities for the patients.The most widely accepted algorithm in the literature is medical treatment,physical therapy and minimally invasive pain-relieving therapies,if necessary,followed by surgical interventions.The common procedure used in neurosurgery practice is the decompression of neural elements followed by fusion...
July 30, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28940484/phase-correction-for-three-dimensional-3d-diffusion-weighted-interleaved-epi-using-3d-multiplexed-sensitivity-encoding-and-reconstruction-3d-muser
#2
Hing-Chiu Chang, Edward S Hui, Pui-Wai Chiu, Xiaoxi Liu, Nan-Kuei Chen
PURPOSE: Three-dimensional (3D) multiplexed sensitivity encoding and reconstruction (3D-MUSER) algorithm is proposed to reduce aliasing artifacts and signal corruption caused by inter-shot 3D phase variations in 3D diffusion-weighted echo planar imaging (DW-EPI). THEORY AND METHODS: 3D-MUSER extends the original framework of multiplexed sensitivity encoding (MUSE) to a hybrid k-space-based reconstruction, thereby enabling the correction of inter-shot 3D phase variations...
September 23, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28927345/the-diagnostic-accuracy-of-somatosensory-evoked-potentials-in-evaluating-neurological-deficits-during-1036-posterior-spinal-fusions
#3
Samyuktha R Melachuri, Jaspreet Kaur, Manasa K Melachuri, Donald J Crammond, Jeffrey R Balzer, Parthasarathy D Thirumala
BACKGROUND: The goal of this study is to assess the sensitivity and specificity of somatosensory evoked potentials (SSEPs) in predicting perioperative neurological deficits during posterior spinal fusions (PSF). METHODS: This study examined the diagnostic accuracy of significant changes of SSEPs and multimodal monitoring to evaluate and predict post-operative neurological deficits after PSF. All 1036 patients underwent PSF at the University of Pittsburgh Medical Center from 2010 to 2012...
September 19, 2017: Neurological Research
https://www.readbyqxmd.com/read/28917409/methods-for-assessing-forward%C3%A2-and%C3%A2-backward-light-scatter%C3%A2-in%C3%A2-patients-with%C3%A2-cataract
#4
Alja Crnej, Nino Hirnschall, Con Petsoglou, Oliver Findl
PURPOSE: To compare objective methods for assessing backward and forward light scatter and psychophysical tests in patients with cataracts. SETTING: Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom. DESIGN: Prospective case series. METHODS: This study included patients scheduled for cataract surgery. Lens opacities were grouped into predominantly nuclear sclerotic, cortical, posterior subcapsular, and mixed cataracts...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28916722/phosphoproteomics-reveals-that-glycogen-synthase-kinase-3-phosphorylates-multiple-splicing-factors-and-is-associated-with-alternative-splicing
#5
Mansi Y Shinde, Simone Sidoli, Katarzyna Kulej, Michael J Mallory, Caleb M Radens, Amanda Reicherter, Rebecca L Myers, Yoseph Barash, Kristen W Lynch, Benjamin A Garcia, Peter S Klein
Glycogen Synthase Kinase-3 (GSK-3) is a constitutively active, ubiquitously expressed protein kinase that regulates multiple signaling pathways. In vitro kinase assays and genetic and pharmacological manipulations of GSK-3 have identified more than 100 putative GSK-3 substrates in diverse cell types. Many more have been predicted on the basis of a recurrent GSK-3 consensus motif (pS/pTXXXS/T), but this prediction has not been tested by analyzing the GSK-3 phosphoproteome. Using stable isotope labeling of amino acids in culture (SILAC) and mass spectrometry (MS) techniques to analyze the repertoire of GSK-3-dependent phosphorylation in mouse embryonic stem cells (ESCs), we found that ~2...
September 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28898771/contrast-enhancement-of-spectral-domain-optical-coherence-tomography-using-spectrum-correction
#6
Guangming Ni, Linbo Liu, Xiaojun Yu, Xin Ge, Si Chen, Xinyu Liu, Xianghong Wang, Shi Chen
We report a spectrum correction method to enhance the image contrast of spectral domain optical coherence tomography (SD-OCT). Our method treats SD-OCT signals as the product of harmonic signals backscattered from a sample comprising a series of discrete reflectors and a window corresponding to the light source spectrum. The method restores the magnitude of the main lobe of the axial point spread function (PSF) by estimating the magnitudes of the backscattered harmonic signals and strengthens OCT signals using these estimated values...
September 6, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28893982/dysregulation-of-spliceosome-gene-expression-in-advanced-prostate-cancer-by-rna-binding-protein-psf
#7
Ken-Ichi Takayama, Takashi Suzuki, Tetsuya Fujimura, Yuta Yamada, Satoru Takahashi, Yukio Homma, Yutaka Suzuki, Satoshi Inoue
Developing therapeutic approaches are necessary for treating hormone-refractory prostate cancer. Activation of androgen receptor (AR) and its variants' expression along with the downstream signals are mostly important for disease progression. However, the mechanism for marked increases of AR signals and its expression is still unclear. Here, we revealed that various spliceosome genes are aberrantly induced by RNA-binding protein PSF, leading to enhancement of the splicing activities for AR expression. Our high-speed sequence analyses identified global PSF-binding transcripts...
September 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28886900/clinical-and-imaging-differences-between-neonates-and-children-with-pyriform-sinus-fistula-which-is-preferred-for-diagnosis-computed-tomography-or-barium-esophagography
#8
Jing Pan, Yan Zou, Le Li, Tian-You Yang, Ji-Liang Yang, Chao Hu
PURPOSE: Pyriform sinus fistula (PSF) is very rare. It is difficult to make an accurate diagnosis preoperatively. The aim of this study is to summarize the characteristics of clinical and radiologic presentations in neonates and children with PSF and to assess which examination is more helpful for diagnosis. METHODS: A retrospective review was performed in 29 patients with PSF at a single center from January 2013 to September 2016. The clinical presentation, computed tomography (CT) scan/magnetic resonance imaging (MRI), and barium esophagogram were evaluated between neonates and children...
August 15, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28886464/muscle-activity-during-backward-and-forward-running-with-body-weight-support
#9
Kenji Masumoto, Michael T Soucy, Joshua P Bailey, John A Mercer
We investigated muscle activity during backward (BR) and forward (FR) running with body weight support (BWS). Ten participants completed BR and FR on a lower body positive pressure treadmill while selecting a preferred speed (PS) for different BWS conditions (0%, 20%, 40%, 60%, and 80%BWS). Muscle activity from the rectus femoris (RF), biceps femoris (BF), tibialis anterior (TA), and gastrocnemius (GA), rating of perceived exertion (RPE), preferred stride frequency (PSF), and PS were measured. Magnitude of muscle activity (BF, TA, and GA), RPE, PSF, and PS were not influenced by the interaction of direction and BWS (P>0...
September 5, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28886048/a-single-source-photon-source-model-of-a-linear-accelerator-for-monte-carlo-dose-calculation
#10
Obioma Nwankwo, Gerhard Glatting, Frederik Wenz, Jens Fleckenstein
PURPOSE: To introduce a new method of deriving a virtual source model (VSM) of a linear accelerator photon beam from a phase space file (PSF) for Monte Carlo (MC) dose calculation. MATERIALS AND METHODS: A PSF of a 6 MV photon beam was generated by simulating the interactions of primary electrons with the relevant geometries of a Synergy linear accelerator (Elekta AB, Stockholm, Sweden) and recording the particles that reach a plane 16 cm downstream the electron source...
2017: PloS One
https://www.readbyqxmd.com/read/28885330/fractional-curve-progression-with-maintenance-of-fusion-mass-in-congenital-scoliosis-an-18-year-follow-up-of-a-case-report
#11
Dong-Gune Chang, Jae Hyuk Yang, Se-Il Suk, Seung-Woo Suh, Jin-Hyok Kim, Seung-Joo Lee, Ki-Ho Na, Jung-Hee Lee
RATIONALE: The management of congenital scoliosis concentrates on early diagnosis and proper surgical treatment before the development of severe deformities. Decision making regarding the appropriate fusion levels, proper surgical treatment, and reduction amount of kyphoscoliosis is very important but difficult in the treatment of congenital scoliosis, especially in young children. PATIENT CONCERNS: We report an 11-year follow-up of revision surgery for fractional curve progression after combined anterior and posterior fusion without hemivertebra resection using pedicle screw fixation (PSF) in congenital kyphoscoliosis at age 4 years (a total 18-year follow-up)...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28885083/risk-factors-for-progressive-neuromuscular-scoliosis-requiring-posterior-spinal-fusion-after-selective-dorsal-rhizotomy
#12
Vijay M Ravindra, Michael T Christensen, Kaine Onwuzulike, John T Smith, Kyle Halvorson, Douglas L Brockmeyer, Marion L Walker, Robert J Bollo
OBJECTIVE Selective dorsal rhizotomy (SDR) via limited laminectomy is an effective treatment of lower-extremity spasticity in the pediatric population. Children with spasticity are also at risk for neuromuscular scoliosis; however, specific risk factors for progressive spinal deformity requiring posterior spinal fusion (PSF) after SDR are unknown. The authors' goal was to identify potential risk factors. METHODS The authors performed a retrospective cohort study of patients who underwent SDR via limited laminectomy between 2003 and 2014 and who had at least 1 year of follow-up...
September 8, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28882632/spatial-specificity-of-the-functional-mri-blood-oxygenation-response-relative-to-neuronal-activity
#13
Denis Chaimow, Essa Yacoub, Kâmil Uğurbil, Amir Shmuel
Previous attempts at characterizing the spatial specificity of the blood oxygenation level dependent functional MRI (BOLD fMRI) response by estimating its point-spread function (PSF) have conventionally relied on spatial representations of visual stimuli in area V1. Consequently, their estimates were confounded by the width and scatter of receptive fields of V1 neurons. Here, we circumvent these limits by instead using the inherent cortical spatial organization of ocular dominance columns (ODCs) to determine the PSF for both Gradient Echo (GE) and Spin Echo (SE) BOLD imaging at 7 T...
September 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/28880994/live-long-and-prosper-plant-soil-feedback-lifespan-and-landscape-abundance-covary
#14
Andrew Kulmatiski, Karen H Beard, Jeanette Norton, Justin Heavilin, Leslie Forero, Josephine Grenzer
Plant soil feedbacks (PSFs) are thought to be important to plant growth and species coexistence, but most support for these hypotheses is derived from short-term greenhouse experiments. Here we use a seven-year, common garden experiment to measure PSFs for seven native and six non-native species common to the western USA. We use these long-term, field-based estimates to test correlations between PSF and plant landscape abundance, species origin, functional type and lifespan. To assess potential PSF mechanisms, we also measured soil microbial community composition, root biomass, nitrogen cycling, bulk density, penetration resistance, and shear strength...
September 7, 2017: Ecology
https://www.readbyqxmd.com/read/28854154/point-spread-function-based-image-reconstruction-in-optical-projection-tomography
#15
Anna Katharina Trull, Jelle van der Horst, Willem Jan Palenstijn, Lucas J van Vliet, Tristan van Leeuwen, Jeroen Kalkman
As a result of the shallow depth of focus of the optical imaging system, the use of standard filtered back projection in optical projection tomography causes space-variant tangential blurring that increases with the distance to the rotation axis. We present a novel optical tomographic image reconstruction technique that incorporates the point spread function (PSF) of the imaging lens in an iterative reconstruction. The technique is demonstrated using numerical simulations, tested on experimental optical projection tomography data of single fluorescent beads, and applied to high-resolution emission optical projection tomography imaging of an entire zebrafish larva...
August 30, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28847092/development-of-a-novel-biochar-psf-mixed-matrix-membrane-and-study-of-key-parameters-in-treatment-of-copper-and-lead-contaminated-water
#16
Jinsong He, Yihua Song, J Paul Chen
Mixed matrix membrane (MMM) has attracted increasing attentions in various applications, such as water treatment. In this study, an innovative biochar/polysulfone (PSF) mixed matrix hollow fiber membrane was fabricated by incorporating micro-sized biochar particles in the PSF matrix. It was demonstrated that the membrane was more hydrophilic than the pure PSF membrane. Higher water flux was obtained. The adsorption of copper and lead on the MMM increased as the pH was increased with the maximum adsorption capacity observed at pH > 4...
November 2017: Chemosphere
https://www.readbyqxmd.com/read/28846091/neat1-scaffolds-rna-binding-proteins-and-the-microprocessor-to-globally-enhance-pri-mirna-processing
#17
Li Jiang, Changwei Shao, Qi-Jia Wu, Geng Chen, Jie Zhou, Bo Yang, Hairi Li, Lan-Tao Gou, Yi Zhang, Yangming Wang, Gene W Yeo, Yu Zhou, Xiang-Dong Fu
MicroRNA (miRNA) biogenesis is known to be modulated by a variety of RNA-binding proteins (RBPs), but in most cases, individual RBPs appear to influence the processing of a small subset of target miRNAs. Here, we report that the RNA-binding NONO-PSF heterodimer binds a large number of expressed pri-miRNAs in HeLa cells to globally enhance pri-miRNA processing by the Drosha-DGCR8 Microprocessor. NONO and PSF are key components of paraspeckles organized by the long noncoding RNA (lncRNA) NEAT1. We further demonstrate that NEAT1 also has a profound effect on global pri-miRNA processing...
August 28, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28844912/the-relevance-of-postoperative-magnetic-resonance-image-in-evaluating-the-epidural-hematoma-after-thoracic-fixation-surgery
#18
Hong Kyung Shin, Il Choi, Sung Woo Roh, Seung Chul Rhim, Sang Ryong Jeon
BACKGROUND: It is difficult to evaluate the significant findings of epidural hematoma in magnetic resonance image (MRI) obtained immediately after thoracic posterior screw fixation (PSF). METHODS: Prospectively, an immediate postoperative MRI was performed in 10 patients who underwent thoracic PSF from April to December 2013. Additionally, we retrospectively analysed the MRI from three patients before hematoma evacuation out of 260 patients who underwent thoracic PSF from January 2000 to March 2013...
August 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28842768/evaluation-of-blood-adsorption-onto-dialysis-membranes-by-time-of-flight-secondary-ion-mass-spectrometry-and-near-field-infrared-microscopy
#19
Satoka Aoyagi, Kiyoshi Abe, Takayuki Yamagishi, Hideo Iwai, Satoru Yamaguchi, Takashi Sunohara
Blood adsorption onto the inside surface of hollow fiber dialysis membranes was investigated by means of time-of-flight secondary ion mass spectrometry (TOF-SIMS) and near-field infrared microscopy (NFIR) in order to evaluate the biocompatibility and permeability of dialysis membranes. TOF-SIMS is useful for the imaging of particular molecules with a high spatial resolution of approximately 100 nm. In contrast, infrared spectra provide quantitative information and NFIR enables analysis with a high spatial resolution of less than 1 μm, which is close to the resolution of TOF-SIMS...
August 25, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28842509/an-improved-analysis-methodology-for-translational-profiling-by-microarray
#20
Thomas Sbarrato, Ruth V Spriggs, Lindsay Wilson, Carolyn Jones, Kate Dudek, Amandine Bastide, Xavier Pichon, Tuija Pöyry, Anne E Willis
Translational regulation plays a central role in the global gene expression of a cell and detection of such regulation has allowed deciphering of critical biological mechanisms. Genome-wide studies of the regulation of translation (translatome) performed on microarrays represent a substantial proportion of studies, alongside with recent advances in deep-sequencing methods. However, there has been a lack of development in specific processing methodologies that deal with the distinct nature of translatome array data...
August 25, 2017: RNA
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