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https://www.readbyqxmd.com/read/29222904/dietary-patterns-change-over-two-years-in-early-adolescent-girls-in-hawai-i
#1
Michelle Ann Mosley, Jinan C Banna, Eunjung Lim, Marie Kainoa Fialkowski, Rachel Novotny
BACKGROUND AND OBJECTIVES: In investigating diet-disease relationships, examination of dietary patterns allows for conclusions to be drawn based on overall intake. This study characterized dietary patterns of early adolescent girls over a two-year period and examined the relationship between dietary patterns and body mass index (BMI). METHODS AND STUDY DESIGN: Cross-sectional analyses were performed using longitudinal data from food records of early adolescent girls (n=148) 9 to 14 years in Hawai'i from the Female Adolescent Maturation (FAM) study...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29221534/on-becoming-a-global-citizen-transformative-learning-through-global-health-experiences
#2
Debra K Litzelman, Adrian Gardner, Robert M Einterz, Philip Owiti, Charity Wambui, Jordan C Huskins, Kathleen M Schmitt-Wendholt, Geren S Stone, Paul O Ayuo, Thomas S Inui, Rachel A Umoren
BACKGROUND: Globalization has increased the demand for international experiences in medical education. International experiences improve medical knowledge, clinical skills, and self-development; influence career objectives; and provide insights on ethical and societal issues. However, global health rotations can end up being no more than tourism if not structured to foster personal transformation and global citizenship. OBJECTIVE: We conducted a qualitative assessment of trainee-reported critical incidents to more deeply understand the impact of our global health experience on trainees...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29219811/non-targeted-hiv-screening-in-emergency-departments-in-the-netherlands
#3
G P M Luiken, I K Joore, A Taselaar, S C E Schuit, S E Geerlings, A Govers, P P M Rood, J M Prins, B E Nichols, A Verbon, T E M S de Vries-Sluijs
BACKGROUND: In the Netherlands a substantial proportion of newly diagnosed human immunodeficiency virus (HIV) patients present late for care and an estimated 12-34% of people living with HIV are undiagnosed. Linkage to care of these patients is important to decrease HIV transmission and to improve individual patient outcomes. We investigated if non-targeted HIV testing in emergency departments is a useful and cost-effective way to identify these patients. METHODS: In a cross-sectional multicentre study, eligible adult patients who underwent phlebotomy were given an active choice to be additionally tested for HIV...
November 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29218131/hypocalcemia-associated-with-subcutaneous-fat-necrosis-of-the-newborn-case-report-and-literature-review
#4
Alphonsus N Onyiriuka, Theodora E Utomi
Subcutaneous fat necrosis of the newborn (SCFNN) is a rare benign inflammatory disorder of the adipose tissue but may be complicated by hypercalcemia or less frequently, hypocalcemia, resulting in morbidity and mortality. Here we report the case of a neonate with subcutaneous fat necrosis who surprisingly developed hypocalcemia instead of hypercalcemia. A full-term female neonate was delivered by emergency cesarean section for fetal distress and was subsequently admitted to the Special Care Baby Unit. The mother's pregnancy was uncomplicated up to delivery...
November 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29215162/delineating-the-association-between-mode-of-delivery-and-postpartum-depression-symptoms-a-longitudinal-study
#5
Patricia Eckerdal, Marios K Georgakis, Natasa Kollia, Anna-Karin Wikström, Ulf Högberg, Alkistis Skalkidou
INTRODUCTION: Although a number of perinatal factors have been implied in the etiology of postpartum depression (PPD), the role of mode of delivery remains controversial. Our aim was to explore the association between mode of delivery and PPD, considering the potentially mediating or confounding role of several covariates MATERIAL AND METHODS: In a longitudinal-cohort study in Uppsala, Sweden, with 3888 unique pregnancies followed-up postpartum, the effect of mode of delivery (spontaneous vaginal delivery, vacuum extraction, elective cesarean section, emergency cesarean section) on self-reported PPD symptoms (Edinburgh Postnatal Depression Scale ≥12) at six weeks postpartum was investigated through logistic regression models and path analysis RESULTS: The overall prevalence of PPD was 13%...
December 7, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29209511/effectiveness-of-composting-as-a-biosecure-disposal-method-for-porcine-epidemic-diarrhea-virus-pedv-infected-pig-carcasses
#6
Sarah Vitosh-Sillman, John Dustin Loy, Bruce Brodersen, Clayton Kelling, Kent Eskridge, Amy Millmier Schmidt
Background: Porcine epidemic diarrhea virus (PEDV) is an enteric disease of swine that has emerged as a worldwide threat to swine herd health and production. Substantial research has been conducted to assess viability of the virus on surfaces of vehicles and equipment, in feed and water, and on production building surfaces, but little is known about the persistence in PEDV-infected carcasses and effective disposal methods thereof. This study was conducted to quantify the persistence of PEDV RNA via quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) at various time-temperature combinations and in infected piglet carcasses subjected to composting...
2017: Porcine Health Management
https://www.readbyqxmd.com/read/29208759/the-role-of-multidetector-computed-tomography-and-the-forced-oscillation-technique-in-assessing-lung-damage-in-adults-with-cystic-fibrosis
#7
Letícia S Lacerda, Agnaldo J Lopes, Alysson R S Carvalho, Alan R M Guimarães, Mônica C Firmida, Marcos C S Castro, Roberto Mogami, Pedro L Melo
BACKGROUND: With increased survival rates and the consequent emergence of an adult population with cystic fibrosis (CF), developing novel tools for periodic evaluations of these patients has become a new challenge. Thus, we sought to determine the contribution of lung-volume quantification using multidetector computed tomography (CT) in adults with CF and to investigate the association between structural changes and functional abnormalities. METHODS: This was a cross-sectional study in which 21 adults with CF and 22 control subjects underwent lung-volume quantification using multidetector CT...
December 5, 2017: Respiratory Care
https://www.readbyqxmd.com/read/29207565/delivery-mode-and-the-transition-of-pioneering-gut-microbiota-structure-composition-and-predicted-metabolic-function
#8
Noel T Mueller, Hakdong Shin, Aline Pizoni, Isabel C Werlang, Ursula Matte, Marcelo Z Goldani, Helena A S Goldani, Maria G Dominguez-Bello
Cesarean (C-section) delivery, recently shown to cause excess weight gain in mice, perturbs human neonatal gut microbiota development due to the lack of natural mother-to-newborn transfer of microbes. Neonates excrete first the in-utero intestinal content (referred to as meconium) hours after birth, followed by intestinal contents reflective of extra-uterine exposure (referred to as transition stool) 2 to 3 days after birth. It is not clear when the effect of C-section on the neonatal gut microbiota emerges...
December 4, 2017: Genes
https://www.readbyqxmd.com/read/29206495/the-clinical-and-pathological-features-of-maternal-gastric-adenocarcinoma-metastatic-to-placenta
#9
Ping Wei, Mulan Jin, Lei Jiang, Yue Wang, Ying Wang, Xiumei Hu, Yungang Zhang
We describe two mothers with metastatic gastric carcinoma involving the placenta. The first was a 35-year-old woman, who presented with a progressive decline in serum fibrinogen level at 34 + 2gestation week and underwent an emergency cesarean section. The second case was a 30-year-old woman who developed intolerable lumbosacral pain and cesarean section was performed at her 37 + 3gestation week. Gross pathological examinations of both placentas were normal, but microscopy showed poorly differentiated adenocarcinoma infiltration in the intervillous space, later proved to be gastric in origin...
December 5, 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/29205206/applications-of-pharmacogenomics-in-regulatory-science-a-product-life-cycle-review
#10
W C Tan-Koi, P C Leow, Y Y Teo
With rapid developments of pharmacogenomics (PGx) and regulatory science, it is important to understand the current PGx integration in product life cycle, impact on clinical practice thus far and opportunities ahead. We conducted a cross-sectional review on PGx-related regulatory documents and implementation guidelines in the United States and Europe. Our review found that although PGx-related guidance in both markets span across the entire product life cycle, the scope of implementation guidelines varies across two continents...
December 5, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29202840/patient-targeted-googling-and-social-media-a-cross-sectional-study-of-senior-medical-students
#11
Aaron N Chester, Susan E Walthert, Stephen J Gallagher, Lynley C Anderson, Michael L Stitely
BACKGROUND: Social media and Internet technologies present several emerging and ill-explored issues for a modern healthcare workforce. One issue is patient-targeted Googling (PTG), which involves a healthcare professional using a social networking site (SNS) or publicly available search engine to find patient information online. The study's aim was to address a deficit in data and knowledge regarding PTG, and to investigate medical student use of SNSs due to a close association with PTG...
December 4, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/29202402/design-synthesis-and-biological-evaluation-of-a-series-of-resorcinol-based-n-benzyl-benzamide-derivatives-as-potent-hsp90-inhibitors
#12
Sun You Park, Yong Jin Oh, Yunmee Lho, Ju Hui Jeong, Kwang-Hyeon Liu, Jaeyoung Song, Soong-Hyun Kim, Eunyoung Ha, Young Ho Seo
Heat shock protein 90 (Hsp90) is a ubiquitous molecular chaperone that is responsible for the stabilization and maturation of many oncogenic proteins. Therefore, Hsp90 has emerged as an attractive target in the field of cancer chemotherapy. In this study, we report the design, synthesis, and biological evaluation of a series of Hsp90 inhibitors. In particular, compound 30f shows a significant Hsp90α inhibitory activity with IC50 value of 5.3 nM and an excellent growth inhibition with GI50 value of 0.42 μM against non-small cell lung cancer cells, H1975...
November 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29198773/sex-and-age-dependent-differences-in-autonomic-nervous-system-functioning-in-adolescents
#13
Massimiliano de Zambotti, Harold Javitz, Peter L Franzen, Ty Brumback, Duncan B Clark, Ian M Colrain, Fiona C Baker
PURPOSE: We assessed sex- and age-dependent differences in a cross-sectional analysis of cardiac autonomic nervous system (ANS) regulation during sleep in adolescents. METHODS: Nocturnal heart rate (HR) and heart rate variability (HRV) metrics, reflecting ANS functioning, were analyzed across the night and within undisturbed rapid eye movement (REM) and non-REM sleep in 149 healthy adolescents (12-22 years; 67 female) from the National Consortium on Alcohol and Neurodevelopment in Adolescence...
December 1, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29190838/slipping-through-the-cracks-a-cross-sectional-study-examining-older-adult-emergency-department-patient-fall-history-post-fall-treatment-and-prevention
#14
Elizabeth M Goldberg, Ellen M McCreedy, Cameron J Gettel, Roland C Merchant
Falls are the leading cause of emergency department (ED) visits for fatal and non-fatal injuries among adults 65 years old and older. We aimed to better understand the fall history, risk for further falls, and actions taken to prevent further falls among this higher fall risk population. This cross-sectional study included older adults without cognitive impairment presenting to the Rhode Island Hospital ED from February to May 2017. Of the 76 participants, 35 self-reported no prior falls, and 41 self-reported at least one prior fall, of whom 20 fell on the day of ED presentation...
December 1, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/29187236/obstruction-in-the-third-portion-of-the-duodenum-due-to-a-diospyrobezoar-a-case-report
#15
Yukinori Yamagata, Kazuyuki Saito, Kosuke Hirano, Yawara Kubota, Ryuji Yoshioka, Takashi Okuyama, Emiko Takeshita, Nobumi Tagaya, Shinichi Sameshima, Tamaki Noie, Masatoshi Oya
BACKGROUND: Duodenal obstruction occurs mainly due to physical lesions such as duodenal ulcers or tumors. Obstruction due to bezoars is rare. We describe an extremely rare case of obstruction in the third portion of the duodenum caused by a diospyrobezoar 15 months after laparoscopic distal gastrectomy for early gastric cancer. CASE PRESENTATION: A 73-year-old man who underwent laparoscopic distal gastrectomy for early gastric cancer 15 months before admission experienced abdominal distension and occasional vomiting...
November 29, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29186388/walking-gross-motor-development-and-brain-functional-connectivity-in-infants-and-toddlers
#16
Natasha Marrus, Adam T Eggebrecht, Alexandre Todorov, Jed T Elison, Jason J Wolff, Lyndsey Cole, Wei Gao, Juhi Pandey, Mark D Shen, Meghan R Swanson, Robert W Emerson, Cheryl L Klohr, Chloe M Adams, Annette M Estes, Lonnie Zwaigenbaum, Kelly N Botteron, Robert C McKinstry, John N Constantino, Alan C Evans, Heather C Hazlett, Stephen R Dager, Sarah J Paterson, Robert T Schultz, Martin A Styner, Guido Gerig, Bradley L Schlaggar, Joseph Piven, John R Pruett
Infant gross motor development is vital to adaptive function and predictive of both cognitive outcomes and neurodevelopmental disorders. However, little is known about neural systems underlying the emergence of walking and general gross motor abilities. Using resting state fcMRI, we identified functional brain networks associated with walking and gross motor scores in a mixed cross-sectional and longitudinal cohort of infants at high and low risk for autism spectrum disorder, who represent a dimensionally distributed range of motor function...
November 23, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29184859/risk-factors-for-massive-postpartum-bleeding-in-pregnancies-in-which-incomplete-placenta-previa-are-located-on-the-posterior-uterine-wall
#17
Hyun Jung Lee, Young Jai Lee, Eun Hee Ahn, Hyeon Chul Kim, Sang Hee Jung, Sung Woon Chang, Ji Yeon Lee
Objective: To identify factors associated with massive postpartum bleeding in pregnancies complicated by incomplete placenta previa located on the posterior uterine wall. Methods: A retrospective case-control study was performed. We identified 210 healthy singleton pregnancies with incomplete placenta previa located on the posterior uterine wall, who underwent elective or emergency cesarean section after 24 weeks of gestation between January 2006 and April 2016...
November 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29179271/-relationship-between-the-risk-of-emergency-cesarean-section-for-nullipara-with-the-prepregnancy-body-mass-index-or-gestational-weight-gain
#18
R F Zhao, W Y Zhang, L Zhou
Objective: To investigate the risk of emergency cesarean section during labor with the pre-pregnancy body mass index or gestational weight gain. Methods: A total of 6 908 healthy nullipara with singleton pregnancy and cephalic presentation who was in term labor in Beijing Obstetrics and Gynecology Hospital from August 1(st), 2014 to September 30(th), 2015 were recruited. They were divided into two groups, the vaginal delivery group (92.88%, 6 416/6 908) and the emergency cesarean section group (7.12%, 492/6 908)...
November 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29177036/sexual-dimorphism-phenotypic-integration-and-the-evolution-of-head-structure-in-casque-headed-lizards
#19
Gregory W Taylor, Juan C Santos, Benjamin J Perrault, Mariana Morando, Carlos Roberto Vásquez Almazán, Jack W Sites
Sexes can differ in features associated with differential reproduction, which can be used during courtship or aggressive encounters. Some traits tend to evolve independently between sexes and emerge as sexually dimorphic within the organismal phenotype. We characterize such a relationship by estimating the phenotypic integration of the head morphology and modularity of the crest in the casque-headed lizards (Corytophanidae). In this clade, some species show extreme sexual dimorphism (e.g., head crests in the genus Basiliscus) while in others, both sexes are monomorphic...
November 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29174839/a-national-study-of-outpatient-health-care-providers-effect%C3%A2-on-emergency-department-visit-acuity-and%C3%A2-likelihood-of-hospitalization
#20
Maria C Raven, Faye Steiner
STUDY OBJECTIVE: Many policymakers believe that expanding access to outpatient care will reduce emergency department (ED) use. However, outpatient health care providers often refer their patients to EDs for evaluation and management. We examine the factors underlying outpatient provider referral, its effect on ED visit volume, and whether referred ED visits are more likely to result in hospitalization than self-referred visits. METHODS: We conducted a cross-sectional study of 19,342 adult (>18 years) respondents to the 2012 to 2014 National Health Interview Survey who reported they had visited an ED at least once in the past 12 months, representing an estimated 44,152,870 US adults...
November 23, 2017: Annals of Emergency Medicine
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