keyword
MENU ▼
Read by QxMD icon Read
search

Pharmaceutical

keyword
https://www.readbyqxmd.com/read/28110506/antibiotic-discovery-throughout-the-small-world-initiative-a-molecular-strategy-to-identify-biosynthetic-gene-clusters-involved-in-antagonistic-activity
#1
Elizabeth Davis, Tyler Sloan, Krista Aurelius, Angela Barbour, Elijah Bodey, Brigette Clark, Celeste Dennis, Rachel Drown, Megan Fleming, Allison Humbert, Elizabeth Glasgo, Trent Kerns, Kelly Lingro, MacKenzie McMillin, Aaron Meyer, Breanna Pope, April Stalevicz, Brittney Steffen, Austin Steindl, Carolyn Williams, Carmen Wimberley, Robert Zenas, Kristen Butela, Hans Wildschutte
The emergence of bacterial pathogens resistant to all known antibiotics is a global health crisis. Adding to this problem is that major pharmaceutical companies have shifted away from antibiotic discovery due to low profitability. As a result, the pipeline of new antibiotics is essentially dry and many bacteria now resist the effects of most commonly used drugs. To address this global health concern, citizen science through the Small World Initiative (SWI) was formed in 2012. As part of SWI, students isolate bacteria from their local environments, characterize the strains, and assay for antibiotic production...
January 22, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28110283/estimated-generic-prices-of-cancer-medicines-deemed-cost-ineffective-in-england-a-cost-estimation-analysis
#2
Andrew Hill, Christopher Redd, Dzintars Gotham, Isabelle Erbacher, Jonathan Meldrum, Ryo Harada
OBJECTIVES: The aim of this study was to estimate lowest possible treatment costs for four novel cancer drugs, hypothesising that generic manufacturing could significantly reduce treatment costs. SETTING: This research was carried out in a non-clinical research setting using secondary data. PARTICIPANTS: There were no human participants in the study. Four drugs were selected for the study: bortezomib, dasatinib, everolimus and gefitinib. These medications were selected according to their clinical importance, novel pharmaceutical actions and the availability of generic price data...
January 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28110169/lack-of-overlap-and-large-discrepancies-in-the-characteristics-of-the-deceased-in-two-sources-of-drug-death-a-linkage-study-of-the-cause-of-death-and-the-police-registries-in-norway-2007-2009
#3
Ellen Johanna Amundsen
BACKGROUND: Registries for drug deaths may include different persons and provide different characteristics of the deceased. The aim of this study was to establish whether a database of drug-induced deaths (Cause of Death Registry (CDR) using the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) definition and the Police registry of drug deaths) included the same persons and provided the same characteristics of the deceased and thus yielded the same information for establishing targeted prevention measures...
January 19, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28109898/composite-particles-based-on-particle-engineering-for-direct-compaction
#4
REVIEW
Zhe Li, Xiao Lin, Lan Shen, YanLong Hong, Yi Feng
Direct compaction (DC) is the preferred method for tablet production. However, only a minority of the active pharmaceutical ingredients (APIs) can be truly manufactured into tablets by DC so far due to that most of APIs lack sufficient functional properties required for DC. Particle engineering with co-processing provides a promising way to obtain various composite API and/or excipient particles with markedly improved functional properties, which makes successful tableting of them by DC possible. This review, as an informative update and supplement, covers the improvement of functional properties of composite API and/or excipient particles via co-processing based on recent developments and researches in the area of particle engineering for DC...
January 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28109793/a-study-of-fasoracetam-s-solid-state-forms-a-potential-anti-alzheimer-pharmaceutical
#5
Bram Harmsen, Koen Robeyns, Johan Wouters, Tom Leyssens
Different solid state forms of the research chemical fasoracetam, which counters the effects of Alzheimer's disease, have been subjected to a thermal and structural analysis. Single crystals were obtained from solution evaporation and from the melt. Single crystal x-ray analyses of the crystals show the existence of two hydrated and one non-hydrated crystalline form of fasoracetam. Under ambient conditions, the hydrate form I is found to be the most stable form, showing a melting point of 57°C. This low melting point, combined with possible water losses could cause problems when formulating the hydrated form and impact the storage conditions of the compound...
January 18, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28109680/-why-do-generic-drugs-fail-to-achieve-an-adequate-market-share-in-greece-empirical-findings-and-policy-suggestions
#6
T Balasopoulos, A Charonis, K Athanasakis, J Kyriopoulos, E Pavi
OBJECTIVES: Since 2010, the memoranda of understanding were implemented in Greece as a measure of fiscal adjustment. Public pharmaceutical expenditure was one of the main focuses of this implementation. Numerous policies, targeted on pharma spending, reduced the pharmaceutical budget by 60.5%. Yet, generics' penetration in Greece remained among the lowest among OECD countries. This study aims to highlight the factors that affect the perceptions of the population on generic drugs and to suggest effective policy measures...
January 9, 2017: Health Policy
https://www.readbyqxmd.com/read/28109551/-economic-impact-of-optimising-antiretroviral-treatment-in-human-immunodeficiency-virus-infected-adults-with-suppressed-viral-load-in-spain-by-implementing-the-grade-a-1-evidence-recommendations-of-the-2015-gesida-national-aids-plan
#7
Esteban Ribera, José Manuel Martínez-Sesmero, Javier Sánchez-Rubio, Rafael Rubio, Juan Pasquau, José Luis Poveda, Alejandro Pérez-Mitru, Celia Roldán, Beatriz Hernández-Novoa
INTRODUCTION: The objective of this study is to estimate the economic impact associated with the optimisation of triple antiretroviral treatment (ART) in patients with undetectable viral load according to the recommendations from the GeSIDA/PNS (2015) Consensus and their applicability in the Spanish clinical practice. METHODS: A pharmacoeconomic model was developed based on data from a National Hospital Prescription Survey on ART (2014) and the A-I evidence recommendations for the optimisation of ART from the GeSIDA/PNS (2015) consensus...
January 18, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28109305/medical-pluralism-and-livestock-health-ethnomedical-and-biomedical-veterinary-knowledge-among-east-african-agropastoralists
#8
Mark A Caudell, Marsha B Quinlan, Robert J Quinlan, Douglas R Call
BACKGROUND: Human and animal health are deeply intertwined in livestock dependent areas. Livestock health contributes to food security and can influence human health through the transmission of zoonotic diseases. In low-income countries diagnosis and treatment of livestock diseases is often carried out by household members who draw upon both ethnoveterinary medicine (EVM) and contemporary veterinary biomedicine (VB). Expertise in these knowledge bases, along with their coexistence, informs treatment and thus ultimately impacts animal and human health...
January 21, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28109083/green-pharmaceutical-analysis-of-drugs-coformulated-with-highly-different-concentrations-using-spiking-and-manipulation-of-their-ratio-spectra
#9
Bassam M Ayoub
Introducing green analysis to pharmaceuticalproducts is considered a significant approach topreserving the environment. This method can be anenvironmentally friendly alternative to the existingmethods, accompanied by a validated automatedprocedure for the analysis of a drug with the lowestpossible number of samples. Different simplespectrophotometric methods were developed forthe simultaneous determination of empagliflozin(EG) and metformin (MT) by manipulating their ratiospectra in their application on a recently approvedpharmaceutical combination, Synjardy tablets...
January 20, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28109021/affordable-orphan-drugs-a-role-for-not-for-profit-organisations
#10
E H Davies, E Fulton, D Brook, D A Hughes
The success of the Regulation on Orphan Medicinal Products in the European Union is evidenced by the 127 orphan drugs that have had market authorisation since 2000. However the incentives aimed to stimulate research and development have had the unintended consequence of increasing drug cost, resulting in many orphan drugs not being cost-effective. Orphan drugs command an increasing share of the pharmaceutical market and account for a disproportionate amount of healthcare expenditure. Orphan drug ownership by socially motivated, not-for-profit organisations may facilitate access to more affordable orphan drugs, for the benefit of patients and healthcare systems alike...
January 20, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28108764/letr-is-a-tetr-family-transcription-factor-from-lysobacter-controlling-antifungal-antibiotic-biosynthesis
#11
Ping Wang, Hongfu Chen, Guoliang Qian, Fengquan Liu
Heat-stable antifungal factor (HSAF) is a newly identified and broad-spectrum antifungal antibiotic from Lysobacter enzymogenes, a ubiquitous environmental proteobacterium. Yet, the regulatory mechanism for HSAF biosynthesis in L. enzymogenes remains poorly understood. Here, we report the identification of a TetR-family protein Le1552 (LetR) from L. enzymogenes strain OH11 that is involved in transcriptional repression of HSAF production. Bacterial one-hybrid and gel mobility shift assays show that LetR directly binds to PHSAF (the promoter region of the HSAF biosynthesis operon)...
January 20, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28108380/the-taste-of-heat-how-humoral-qualities-act-as-a-cultural-filter-for-chemosensory-properties-guiding-herbal-medicine
#12
Matthias S Geck, Stefano Cabras, Laura Casu, Alberto J Reyes García, Marco Leonti
ETHNOPHARMACOLOGICAL RELEVANCE: Organoleptic properties, and more specifically chemosensory cues, have been shown to guide therapeutic applications of medicinal plants. Humoral qualities, on the other hand, are widely believed to be an abstract concept, mainly applied post hoc to validate therapy. However, the nexus between humoral qualities, chemosensory properties, and medicinal plant uses has never been systematically assessed. AIM OF THE STUDY: To systematically analyse the correlations between chemosensory properties, humoral qualities, and medicinal uses of selected botanical drugs...
January 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28108379/-dark-singlet-oxygen-and-epr-spin-trapping-as-convenient-tools-to-assess-photolytic-drug-degradation
#13
Peter Persich, Steven Hostyn, Céline Joie, Guy Winderickx, Jeroen Pikkemaat, Edwin P Romijn, Bert U W Maes
Forced degradation studies are an important tool for a systematic assessment of decomposition pathways and identification of reactive sites in active pharmaceutical ingredients (APIs). Two methodologies have been combined in order to provide a deeper understanding of singlet-oxygen related degradation pathways of APIs under light irradiation. Firstly, we report that a "dark" singlet oxygen test enables the investigation of drug reactivity towards singlet oxygen independently of photolytic irradiation processes...
January 17, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28108108/pharmaceuticals-and-personal-care-products-in-plants
#14
REVIEW
Mireia Bartrons, Josep Peñuelas
Pharmaceuticals and personal-care products (PPCPs) derived from agricultural, urban, and industrial areas accumulate in plants at concentrations (ng to μg kg(-1)) that can be toxic to the plants. Importantly, the dietary intake of these PPCP-contaminated plants may also pose a risk to human health, but currently little is known about the fate of PPCPs in plants and their effect on or risk to the ecosystem. In this Opinion article we propose that in-depth research on the use of plants as a monitoring device for assessing the use and environmental presence of PPCPs is warranted...
January 17, 2017: Trends in Plant Science
https://www.readbyqxmd.com/read/28108094/metabolic-profiling-identification-of-metabolites-formed-in-mediterranean-mussels-mytilus-galloprovincialis-after-diclofenac-exposure
#15
Bénilde Bonnefille, Lauren Arpin-Pont, Elena Gomez, Hélène Fenet, Frédérique Courant
Despite the growing concern on the presence of pharmaceutically active compounds in the environment, few studies have been conducted on their metabolism in marine organisms. In this study, a non-targeted strategy based on the generation of chemical profiles generated by liquid chromatography combined with high resolution mass spectrometry was used to highlight metabolite production by the Mediterranean mussel (Mytilus galloprovincialis) after diclofenac exposure. This method allowed revealing the production of 13 metabolites in mussel tissues...
January 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28108073/reference-control-data-obtained-from-an-in-vivo-comet-micronucleus-combination-assay-using-sprague-dawley-rats
#16
Sawako Kasamoto, Shoji Masumori, Jin Tanaka, Maya Ueda, Masahito Fukumuro, Miho Nagai, Jyoji Yamate, Makoto Hayashi
According to the International Conference on Harmonization Guidance on Genotoxicity Testing and Data Interpretation for Pharmaceuticals Intended for Human Use (ICH S2(R1)), a positive response in any in vitro assay necessitates additional in vivo test(s) (other tissue/endpoint) in addition to the erythrocyte micronucleus test when Option 1 of the test battery is selected. When Option 2 of the test battery is selected, a bacterial gene mutation test and two in vivo tests with different tissues/endpoint are required...
January 17, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28107994/application-of-passive-sampling-devices-based-on-multi-walled-carbon-nanotubes-for-the-isolation-of-selected-pharmaceuticals-and-phenolic-compounds-in-water-samples-possibilities-and-limitations
#17
Aleksandra Jakubus, Magdalena Tyma, Piotr Stepnowski, Monika Paszkiewicz
Nowadays, carbon nanotubes, as commercially available materials, have attracted great attention because of their unique physicochemical properties, especially their strong adsorption abilities. This paper deals with the possibilities and limitations of the application of multi-walled carbon nanotubes as an alternative sorbent in passive sampling devices for the isolation of selected pharmaceuticals and phenolic compounds directly in water samples. Compounds with different properties, including sulfapyridine, sulfamethoxazole, carbamazepine, p-nitrophenol, 17-β-estradiol, 3,5-dichlorophenol and diclofenac were selected as model compounds...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107993/using-multiple-process-analytical-technology-probes-to-monitor-multivitamin-blends-in-a-tableting-feed-frame
#18
Pedro Durão, Clémence Fauteux-Lefebvre, Jean-Maxime Guay, Nicolas Abatzoglou, Ryan Gosselin
As Process Analytical Technology (PAT) implementation grows in the pharmaceutical industry, more studies are being performed to evaluate its suitability in new applications and processes within the manufacturing chain. As the last step in tablet production, the compression stage represents a critical phase that ensures product quality. In-line control put in place at this stage has the potential to detect powder blends that are out of specification limits and, thus, help to improve product quality. The objectives of the present project are to quantify the composition of a commercial 31-component multivitamin powder blend in real time on an industrial feed frame, using 3 different PAT tools: light-induced fluorescence spectroscopy, near infrared spectroscopy and red, green and blue color imaging...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107918/bismuth-nanoparticles-carbon-nanotubes-modified-sensor-for-sulfasalazine-analysis
#19
Biljana Nigović, Sandra Jurić, Iva Mitrović
Nanocomposite of bismuth nanoparticles and carbon nanotubes in Nafion matrix was used as modifier for glassy carbon electrode in analysis of anti-inflamatory drug sulfasalazine. The nanocomposite surface exhibited exceptional synergy and remarkable enhancement effect to the voltammetric response of drug. The surface morphology and structure characterization of the modified electrodes was characterized by scanning electron microscopy, energy dispersive X-ray spectroscopy and cyclic voltammetry. The sensor exhibited excellent electroanalytical performance for drug determination in comparison with bismuth film electrode...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107915/a-clean-photometric-method-for-the-determination-of-losartan-potassium-in-pharmaceuticals-exploiting-light-scattering-effect-and-employing-a-multicommuted-flow-analysis-approach
#20
Manoel J A Lima, Boaventura F Reis
This paper describes an environmentally friendly procedure for the determination of losartan potassium (Los-K) in pharmaceuticals. The photometric method was based on the light scattering effect due to particles suspension, which were formed by the reaction of Los-K with Cu (II) ions. The method was automated employing a multicommuted flow analysis approach, implemented using solenoid mini-pumps for fluid propelling and a homemade LED based photometer. Under the optimized experimental conditions, the procedure showed a linear relationship in the concentration range of 23...
March 1, 2017: Talanta
keyword
keyword
6721
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"